hematologic disease: A disease involving the hematopoietic system.
Other and unspecified diseases of blood and blood-forming organs
DOID EFO Endpoint Browser PheWeb
D3_BLOODNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519870 |
1. Apply sex-specific ruleNone |
519870 |
2. Check conditionsNone |
519870 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1031 |
4. Check minimum number of eventsNone |
1031 |
5. Include endpointsNone |
1031 |
6. Filter based on genotype QC (FinnGen only) |
1001 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified diseases of blood and blood-forming organs
based on the number of shared cases.
Similar with more cases:
- Other diseases of blood and blood-forming organs
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6321 | 3318 | 2939 |
| Only index persons | 5103 | 2725 | 2378 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.08 |
| Only index persons | 0.10 | 0.10 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 59.07 | 58.15 | 60.11 |
| Only index persons | 57.37 | 55.93 | 59.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1001 | 535 | 466 |
| Unadjusted period prevalence (%) | 0.20 | 0.19 | 0.21 |
| Median age at first event (years) | 60.58 | 58.53 | 62.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1031
- Matched controls
- 10310
TimeCodeWAS
↥TODO / Current known limitations:
- Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
- Legend / how to read the glyphs.
- Proper column names.
- Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
- Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
- Download CSV not working.
- No filters and sorters.
- Limited amount of endpoints with TimeCodeWAS data.
- Cross-links to Risteys lab test pages for lab test codes.
D75.9 (45576417)
D75.1 (45532998)
D75.2 (45557096)
D75.0 (45576416)
D75.8 (45605384)
TNE25 (2001307884)
SMOKING-2-2-0 (2002330110)
SMOKING-2-3-0 (2002330113)
27811-9 (3000515)
1952-1 (3013201)
31204-1 (3013527)
3209-4 (3019250)
15061-5 (3024172)
3243-3 (3036489)
33721-2 (3045142)
55774-4 (40758895)
55776-9 (40758897)
50373000 (4177340)
60621009 (4245997)
9732/3-C42.1 (44500967)
9962/3-C42.1 (44502853)
9950/3-C42.1 (44504717)
D47.1 (45600598)
77190-7 (46237023)
93362-2 (1002183)
TPH00 (2001309596)
SMOKING-1-1-0 (2002330116)
78445-4 (21492711)
81861-7 (21494434)
80187-8 (21494670)
18314-5 (3000093)
3255-7 (3016407)
16933-4 (3021879)
4533-6 (3024403)
50659-2 (3029715)
51628-6 (3042111)
33042-3 (3047189)
D72.8 (45561931)
D69.6 (45581327)
100898-6 (1761868)
28998 (2000301677)
2898X (2000402721)
E78.01 (2000501514)
FM1AE (2001303278)
JN1AE (2001305517)
JN3AE (2001305555)
R4110 (2001310233)
WW500 (2001310603)
XW000 (2001310618)
WX002 (2001310758)
ZXE00 (2001311394)
Z2221 (2001311556)
117 (2001600117)
189 (2001600188)
81231-3 (21494890)
31111-8 (3000012)
890-4 (3001079)
1927-3 (3002032)
882-1 (3003694)
2868-8 (3005229)
19232-8 (3007628)
4542-7 (3012336)
22314-9 (3013327)
8039-0 (3014959)
2865-4 (3015322)
16128-1 (3017143)
14979-9 (3018677)
5195-3 (3019284)
2889-4 (3020876)
600-7 (3023368)
2874-6 (3023465)
14196-0 (3023520)
14933-6 (3026493)
8040-8 (3027529)
4679-7 (3027945)
42810-2 (3029080)
50796-2 (3029338)
50797-0 (3029379)
33863-2 (3030366)
5894-1 (3033658)
35559-4 (3035797)
29953-7 (3037522)
40982-1 (3038288)
32730-4 (3043723)
32731-2 (3043747)
43730-1 (3043849)
40987-0 (3043924)
34531-4 (3044640)
48065-7 (3051714)
95941-1 (36031861)
261QX0200X (38004268)
10 (38004455)
82 (38004501)
117617002 (4035726)
9960/3-C42.1 (44502317)
E03.9 (45537945)
D75 (45547613)
D47.2 (45566693)
C92.1 (45576367)
D47.3 (45576400)
D47 (45586111)
D45 (45595761)
C90.0 (45600562)
75622-1 (46235355)
77397-8 (46236098)
26485-3 (3019069)
26450-7 (3006504)
30180-4 (3022096)
26478-8 (3002030)
14804-9 (3022250)
26511-6 (3018010)
11 (38004456)
26449-9 (3013115)
26474-7 (3019198)
26484-6 (3001604)
26444-0 (3006315)
751-8 (3013650)
715-3 (3021589)
24351-9 (3004588)
2885-2 (3020630)
14631-6 (3006140)
69738-3 (42870588)
1751-7 (3024561)
51435-6 (3029713)
2276-4 (3001122)
72493-0 (43055120)
2465-3 (3005719)
6768-6 (3035995)
L01XX05 (21603787)
60517-0 (40763571)
33944-0 (3047169)
D64.9 (45600610)
36916-5 (3034860)
15189-4 (3007778)
3034-6 (3004789)
14798-3 (3022948)
29760-6 (3005772)
OP (9202)
30385-9 (3002385)
1988-5 (3020460)
2472-9 (3028026)
54067-4 (3051552)
14338-8 (3013742)
58435-9 (40761536)
62238-1 (40764999)
1742-6 (3006923)
30248-9 (3015399)
28541-1 (3002179)
55429-5 (40758558)
34534-8 (3044889)
26498-6 (3017181)
26515-7 (3007461)
30428-7 (3024731)
20570-8 (3009542)
26453-1 (3026361)
28539-5 (3035941)
718-7 (3000963)
44 (38004484)
26464-8 (3010813)
28540-3 (3003338)
26524-9 (3021440)
2753-2 (3018418)
24339-4 (3000991)
26446-5 (3025159)
25700-6 (3037756)
OMOP5117446 (33004)
24357-6 (3037467)
14732-2 (3021960)
14879-1 (3003458)
14682-9 (3020564)
I10 (45591453)
2823-3 (3023103)
A49.9 (45590816)
57782-5 (40760892)
51486-9 (3029879)
2951-2 (3019550)
87829-8 (36304419)
2601-3 (3012095)
14731-4 (3019309)
29265-6 (3020059)
51485-1 (3030306)
GD1AA (2001303617)
2458-8 (3007164)
1805-1 (3016417)
13 (38004458)
51483-6 (3030467)
1995-0 (3021347)
47210-0 (3048773)
ZX120 (2001311495)
72160-5 (43054903)
OMOP4822461 (32036)
14647-2 (3019900)
34487-9 (3044938)
14646-4 (3023602)
OMOP4822458 (581477)
57778-3 (40760888)
51480-2 (3031040)
34714-6 (3032080)
10839-9 (3021337)
22748-8 (3001308)
19072-8 (3016431)
30405-5 (3018095)
7852-7 (3010130)
7853-5 (3015635)
30391-7 (3002582)
3016-3 (3009201)
J05AB11 (21603137)
22246-3 (3017918)
22664-7 (3020779)
50554-5 (3029287)
48404-8 (3049804)
1920-8 (3013721)
58410-2 (40761511)
I25.1 (45596196)
4548-4 (3004410)
80223-1 (21494815)
J01EE01 (21602961)
4537-7 (3013707)
20454-5 (3014051)
251B00000X (38004193)
2000-8 (3015377)
21 (8717)
ER (9203)
B01AB05 (21600976)
C91.1 (45600564)
ERIP (262)
22 (8756)
14749-6 (3013826)
5128-4 (3001334)
Z01.8 (45581003)
207NI0002X (38003841)
2324-2 (3026910)
N02AX02 (21604298)
53292-9 (3041096)
33762-6 (3029187)
UJD10 (2001304788)
L03AA02 (21603851)
6968-2 (3009445)
IP (9201)
31017-7 (3019050)
19926-5 (3011505)
19870-5 (3020158)
20150-9 (3024653)
68438-1 (40771025)
5802-4 (3021601)
25428-4 (3009261)
2514-8 (3035350)
H02AB06 (21602734)
A07EA01 (21600653)
A04AA01 (21600493)
Z3226 (2001311560)
6 (38004451)
OMOP4822462 (581458)
2756-5 (3015736)
93 (38004510)
1 (38004446)
C03CA01 (21601518)
M04AA01 (21604131)
Z71.2 (45552100)
ZXD10 (2001311387)
J01DB01 (21602870)
ZXE10 (2001311401)
14920-3 (3008486)
A02BC02 (21600097)
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint D3_BLOODNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_BLOODNAS | 2.238 [1.91, 2.63] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.245 |
During the follow-up period (1.1.1998 — 31.12.2019), 570 out of 2131 females with D3_BLOODNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_BLOODNAS | 2.256 [1.9, 2.67] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 665 out of 1883 males with D3_BLOODNAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_BLOODNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.227% | 0.362% |
| 5 | 1.374% | 2.281% |
| 10 | 3.61% | 5.483% |
| 15 | 6.907% | 9.997% |
| 20 | 11.592% | 16.14% |
Relationships between endpoints
↥Index endpoint: D3_BLOODNAS – Other and unspecified diseases of blood and blood-forming organs
GWS hits: -