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Peripheral retinal degeneration

DOID EFO Endpoint Browser PheWeb

H7_PERIPHRETINADEGEN

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H35.4
  • Hospital discharge: ICD-9 — 3626
  • Hospital discharge: ICD-8 — 37711
  • Cause of death: ICD-10 — H35.4
  • Cause of death: ICD-9 — 3626
  • Cause of death: ICD-8 — 37711

2 out of 7 registries used, show all original rules.

1328

4. Check minimum number of events

None

1328

5. Include endpoints

None

1328

6. Filter based on genotype QC (FinnGen only)

1196

Control definitions (FinnGen only)

Control exclude
H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H35
Name in latin
Degeneratio peripherica retinae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8552 5217 3289
Only index persons 7974 4943 3031
Unadjusted period prevalence (%)
Whole population 0.13 0.15 0.09
Only index persons 0.16 0.18 0.12
Median age at first event (years)
Whole population 54.77 54.91 54.52
Only index persons 53.95 54.19 53.57

-FinnGen-

Key figures

All Female Male
Number of individuals 1196 739 457
Unadjusted period prevalence (%) 0.24 0.26 0.21
Median age at first event (years) 54.92 53.23 57.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1243
Matched controls
12430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H33.3
ICD-10 Finland
Retinal breaks without detachment
1319.3
322.7
301
*
CKC12
NOMESCO Finland
Photocoagulation of retina
587.2
307.7
450
12
H35.4
ICD-10 Finland
Peripheral retinal degeneration
4503599627370496.0
307.7
1180
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
2659.0
247.3
231
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
1281.8
225.2
213
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
61.8
145.3
81
14
WX140
NOMESCO Finland
Parabulbar anesthesy
14.7
138.4
128
96
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
64.6
132.0
73
12
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.3
123.8
237
449
H52.1
ICD-10 Finland
Myopia
9.4
119.0
150
178
H43.8
ICD-10 Finland
Other disorders of vitreous body
5.2
111.0
265
611
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
18.7
104.2
84
48
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
33.1
97.6
63
20
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.9
93.4
186
362
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.0
78.2
264
784
H43.1
ICD-10 Finland
Vitreous haemorrhage
17.4
75.9
63
38
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
190.9
69.9
72
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
83.7
63.7
71
9
CKD40
NOMESCO Finland
Endophotocoagulation of retina
627.9
61.3
60
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.5
61.3
166
415
H26.4
ICD-10 Finland
After-cataract
3.9
57.8
191
552
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
149.2
54.3
57
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.5
53.7
513
2691
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
78.9
53.5
60
8
H26.2
ICD-10 Finland
Complicated cataract
16.3
51.4
44
28
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.5
48.6
452
2319
CKC60
NOMESCO Finland
Local buckling of sclera using implant
+∞
46.1
44
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
42.6
637
3954
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
42.1
273
1167
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.8
41.7
99
221
CKC30
NOMESCO Finland
Cryopexy of detached retina
+∞
40.9
39
*
3626A
ICD-9 Finland
Other retinal disorders, Peripheral retinal degenerations
+∞
39.8
38
*
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
39.8
38
*
H26.02
ICD-10 Finland
Presenil cataract
6.0
37.4
67
116
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
+∞
33.5
32
*
H25.1
ICD-10 Finland
Senile nuclear cataract
2.2
33.3
366
1964
S01ED51
ATC
timolol, combinations; ophthalmic
3.4
31.3
122
389
XCK10
NOMESCO Finland
Photography of fundus of eye
3.1
29.0
127
434
H53.1
ICD-10 Finland
Subjective visual disturbances
3.1
28.7
126
431
XCD10
NOMESCO Finland
Electrophysiological examination of eye
5.9
28.4
52
92
37711
ICD-8 Finland
Other diseases of retina and optic nerve, Degeneratio retinae
+∞
28.2
27
*
H33.5
ICD-10 Finland
Other retinal detachments
36.0
27.5
35
10
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
28.5
26.8
36
13
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
26.1
25
*
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
26.1
25
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
74.3
25.9
29
*
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
45.3
25.6
31
7
ZXA10
NOMESCO Finland
Bilateral
2.2
25.1
252
1286
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
57.2
24.1
28
5
XCK00
NOMESCO Finland
Perimetry
3.3
23.9
92
290
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
23.0
22
*
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
21.9
21
*
XCH00
NOMESCO Finland
Eye pressure measurement
3.7
21.9
72
205
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
117.1
21.6
23
*
3744
FHL
Pericardial identification surgery with coagulation (includes epi- and intrascleral indications and eg Lincoff catheter)
+∞
20.9
20
*
3745
FHL
Hard membrane girding, cerclage with coagulation
213.4
20.6
21
*
H44.2
ICD-10 Finland
Degenerative myopia
111.9
20.6
22
*
XCD20
NOMESCO Finland
Photoangiography of eye
40.8
19.5
24
6
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
18.8
18
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
182.5
17.6
18
*
H35.37
ICD-10 Finland
Macular holes
182.5
17.6
18
*
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
7.2
17.4
26
37
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
16.7
16
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
172.2
16.5
17
*
Z3229
NOMESCO Finland
Other healthcare associate professional
2.4
16.1
115
504
H40.0
ICD-10 Finland
Glaucoma suspect
2.4
15.9
113
494
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
15.7
15
*
S01ED01
ATC
timolol; ophthalmic
3.7
15.3
49
137
H33
ICD-10 Finland
Retinal detachments and breaks
29.0
15.2
20
7
S01BC05
ATC
ketorolac; ophthalmic
3.4
15.2
56
172
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
+∞
14.6
14
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
14.6
14
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
34.4
13.5
17
5
S01EC01
ATC
acetazolamide; systemic
4.5
12.9
31
70
S01EA03
ATC
apraclonidine; ophthalmic
11.1
12.5
23
21
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
131.3
12.5
13
*
H35.36
ICD-10 Finland
Macular cyst
131.3
12.5
13
*
H43.3
ICD-10 Finland
Other vitreous opacities
4.5
12.2
29
65
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
12.1
159
881
XCW10
NOMESCO Finland
Assessment of vision
5.1
12.0
25
50
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.0
11.9
54
188
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
47.1
11.9
14
*
S01BC03
ATC
diclofenac; ophthalmic
4.0
11.8
33
84
H53.4
ICD-10 Finland
Visual field defects
3.8
11.7
36
98
H33.2
ICD-10 Finland
Serous retinal detachment
+∞
11.5
11
*
S01EC03
ATC
dorzolamide; ophthalmic
5.0
10.8
23
47
S01EE01
ATC
latanoprost; ophthalmic
2.4
10.7
75
326
WX142
NOMESCO Finland
Sub-tenon anesthesy
13.0
10.7
18
14
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
11.3
10.6
19
17
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.6
10.4
59
232
H40.9
ICD-10 Finland
Glaucoma, unspecified
3.7
9.7
30
82
H53.9
ICD-10 Finland
Visual disturbance, unspecified
2.7
9.7
53
205
37600
ICD-8 Finland
Detachment of retina, Primaria
+∞
9.4
9
*
CKC65
NOMESCO Finland
Removal of buckling implant from sclera
+∞
9.4
9
*
F05
ICPC
Visual disturbance other
2.8
9.3
46
169
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.1
9.2
92
463
ZXA05
NOMESCO Finland
Left side
1.6
9.1
277
1929
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.2
8.8
35
113
H25.0
ICD-10 Finland
Senile incipient cataract
2.2
8.7
76
363
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.8
8.7
138
811
H25.8
ICD-10 Finland
Other senile cataract
1.9
8.7
114
632
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
8.3
8
*
H30.2
ICD-10 Finland
Posterior cyclitis
+∞
8.3
8
*
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
10.8
8.3
15
14
H35.9
ICD-10 Finland
Retinal disorder, unspecified
22.2
8.0
11
5
ZXA00
NOMESCO Finland
Right side
1.5
7.8
295
2142
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
3.4
7.7
27
81
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.6
7.6
195
1301
A98
ICPC
Health maint/preventive medicine
2.1
7.6
1185
11254
S01FA01
ATC
atropine; ophthalmic
11.9
7.6
13
11
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
8.9
7.6
15
17
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
80.6
7.4
8
*
R01AD09
ATC
mometasone; nasal
1.4
7.3
524
4270
3619X
ICD-9 Finland
Retinal detachments and defects, Unspecified retinal detachment
+∞
7.3
7
*
H31.0
ICD-10 Finland
Chorioretinal scars
+∞
7.3
7
*
3747
FHL
Combined ablation and vitreous surgery with coagulation
+∞
7.3
7
*
S01EC04
ATC
brinzolamide; ophthalmic
2.4
7.2
47
199
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
13.9
6.9
11
8
H57.1
ICD-10 Finland
Ocular pain
2.3
6.9
50
222
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
6.1
6.8
17
28
114
Kela drug reimbursment
Glaucoma
1.9
6.7
90
503
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
70.2
6.4
7
*
S01BA04
ATC
prednisolone; ophthalmic
2.9
6.4
29
102
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
2.7
6.3
32
120
S01GX01
ATC
cromoglicic acid; ophthalmic
1.5
6.3
222
1587
CKC75
NOMESCO Finland
Removal of cerclage from sclera
+∞
6.3
6
*
A02BC05
ATC
esomeprazole; systemic
1.4
6.2
468
3822
F29
ICPC
Eye symptom/complaint other
1.7
6.1
122
764
ZYC01
NOMESCO Finland
Remote contact by phone
1.9
6.0
71
381

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
558
4371
1.50
10.92
4.1
3.8
0.01
0.14
estimate
0.68
146
962
701
5810
1.47
10.00
4.4
3.9
0.00
3.95
estimate
1.07
175
1211
691
5741
1.46
9.54
4.4
3.9
0.00
0.00
estimate
0.50
174
1184
702
5851
1.46
9.52
4.4
3.9
0.02
0.28
estimate
0.47
164
1137
611
5052
1.41
8.12
2.7
2.4
79.85
77.81
nmol/l
1.01
572
4592
143
868
1.73
8.05
3.5
3.9
1.23
1.23
mmol/l
0.47
126
754
1156
10861
1.92
8.05
15.8
14.2
—
—
—
0
0
663
5571
1.41
7.97
6.7
7.0
1.22
1.21
mmol/l
2.06
571
4815
1184
11229
2.15
7.82
22.1
20.5
77.91
76.07
umol/l
1.02
1175
11107
1153
10850
1.87
7.60
19.4
18.6
3.97
3.97
mmol/l
0.14
1133
10632
1150
10826
1.83
7.38
19.2
18.4
139.80
139.70
mmol/l
0.70
1131
10625
940
8477
1.45
7.08
5.0
4.5
14.92
14.74
pmol/l
1.58
868
7859
400
3135
1.41
6.96
3.8
3.3
0.03
0.31
estimate
0.51
138
924
421
3342
1.39
6.75
4.6
4.1
7.40
7.40
ph
0.16
314
2446
401
3163
1.40
6.66
4.4
4.0
0.00
0.01
estimate
0.96
164
1103
1069
9934
1.54
6.51
5.9
5.4
1.88
1.93
mu/l
0.51
1006
9251
554
4640
1.35
6.21
3.8
3.4
6.25
6.22
ph
0.29
314
2653
1194
11464
2.05
5.92
26.3
24.2
249.80
252.44
e9/l
0.73
1180
11254
1194
11465
2.05
5.90
26.2
24.1
91.26
91.22
fl
0.11
1186
11355
326
2527
1.39
5.89
5.0
4.6
—
—
—
0
0
1194
11467
2.05
5.86
26.4
24.6
40.21
40.26
%
0.12
1186
11349
1194
11467
2.05
5.86
26.3
24.2
6.63
6.67
e9/l
0.24
1176
11229
1194
11467
2.05
5.86
26.2
24.1
30.40
30.34
pg
0.50
1186
11358
1194
11467
2.05
5.86
26.3
24.1
4.48
4.47
e12/l
0.34
1177
11232
1194
11470
2.04
5.81
26.5
24.3
135.41
134.73
g/l
1.00
1186
11360
966
8862
1.40
5.73
21.3
19.7
13.61
13.64
%
0.37
956
8742
1115
10524
1.58
5.62
17.1
15.9
21.24
24.04
mg/l
2.13
936
8698
1167
11145
1.77
5.57
12.9
12.0
25.22
25.92
u/l
0.85
1137
10858
317
2474
1.38
5.44
2.6
2.7
5.04
6.04
e6/l
0.60
288
2278
197
1413
1.47
5.43
2.2
2.4
107.11
118.55
ug/g
0.17
159
1138
487
4059
1.33
5.42
4.2
3.9
52.98
106.26
e6/l
1.18
360
2876
570
4862
1.32
5.38
13.8
11.3
0.00
0.00
e9/l
1.45
499
3991
826
7423
1.34
5.37
4.8
4.5
—
3.55
—
0
11
433
3575
1.32
5.07
3.5
3.4
110.90
69.32
e6/l
0.24
350
2745
49
249
2.01
4.89
5.2
4.4
—
—
—
0
0
426
3554
1.30
4.52
2.8
2.6
62.17
84.25
u/l
0.47
390
3308
269
2109
1.35
4.40
3.2
2.9
526.21
526.79
mosm/kgh2o
0.01
237
1862
781
7089
1.27
4.04
4.9
4.7
78.86
1613.03
e6/l
1.52
14
101
285
2285
1.32
3.97
1.7
1.7
438.44
32899965.87
pmol/l
2.40
245
1921
1064
10082
1.38
3.93
6.7
6.1
38.83
39.00
mmol/mol
0.29
1002
9473
502
4334
1.27
3.93
3.6
3.1
—
—
—
0
0
121
841
1.49
3.92
3.8
3.9
—
—
—
0
0
392
3287
1.28
3.89
3.1
3.1
1153.51
1189.18
ng/l
0.06
349
2815
132
940
1.45
3.78
5.0
4.4
0.10
0.14
%
0.29
31
253
309
2523
1.30
3.75
1.3
1.3
0.68
1.37
u/ml
2.48
93
711
369
3088
1.28
3.69
3.4
3.3
0.30
0.43
e6/l
1.01
292
2272
128
915
1.44
3.60
2.7
2.3
0.16
0.50
e6/l
2.06
117
867
588
5213
1.24
3.53
3.3
3.0
133.25
122.73
ug/l
0.35
543
4877
109
760
1.48
3.49
2.5
2.7
—
—
—
0
0
1081
10309
1.37
3.49
5.4
5.1
5.91
5.90
mmol/l
0.02
1011
9541
368
3100
1.27
3.45
5.7
5.3
2.02
2.59
ug/l
1.09
332
2805
82
540
1.56
3.43
2.1
2.3
—
—
—
0
0
13
37
3.54
3.40
1.8
2.0
0.00
0.00
estimate
-0.00
13
37
372
3143
1.26
3.39
3.3
3.0
0.00
0.04
0.74
11
69
132
960
1.42
3.39
5.5
4.7
0.07
0.15
%
0.53
28
241
484
4217
1.24
3.36
4.2
3.7
69.10
59.21
ng/l
0.11
327
2928
269
2187
1.29
3.34
1.3
1.3
40.75
31.36
iu/ml
0.27
71
671
309
2570
1.27
3.19
4.2
4.0
1.02
1.61
kg/l
0.50
204
1705
503
4421
1.23
3.17
2.1
2.2
—
—
—
0
0
99
693
1.47
3.13
3.2
2.7
135.67
128.69
g/l
2.41
93
674
69
449
1.57
3.07
1.2
1.3
0.87
1.19
u/ml
—
9
36
133
987
1.39
3.06
5.2
4.4
0.72
1.01
%
0.66
32
301
74
495
1.53
2.93
1.3
1.2
—
—
—
0
0
446
3908
1.22
2.82
2.9
3.5
2.35
2.36
mmol/l
0.44
414
3575
899
8439
1.24
2.82
8.5
8.2
76.10
79.67
u/l
1.81
862
8038
165
1286
1.33
2.78
1.6
1.7
—
—
—
0
0
126
943
1.37
2.77
4.8
4.2
0.57
0.72
%
0.27
28
287
1097
10563
1.33
2.66
5.4
5.1
4.61
4.69
mmol/l
1.64
1034
9920
692
6355
1.20
2.61
9.9
9.7
4.06
4.07
e9/l
0.03
623
5572
645
5904
1.19
2.46
6.2
6.6
11.66
11.49
umol/l
0.09
610
5661
1108
10708
1.32
2.42
6.1
5.8
2.67
2.74
mmol/l
2.26
1044
10015
548
4954
1.19
2.39
4.8
5.0
35.70
35.72
g/l
0.03
506
4663
82
586
1.43
2.38
1.2
1.2
—
—
—
0
0
1047
10058
1.26
2.31
4.5
4.3
1.26
1.30
mmol/l
0.93
978
9319
27
148
1.84
2.30
1.9
2.2
32.22
32.28
pg
0.02
27
148
552
5010
1.18
2.26
6.5
6.3
1.21
1.21
mmol/l
0.48
518
4646
627
5753
1.18
2.26
7.3
6.2
2.09
1.91
e9/l
0.51
574
5076
259
2193
1.23
2.24
1.7
1.5
2.37
2.46
g/l
0.33
165
1368
106
801
1.35
2.23
2.5
2.3
12.55
12.82
nmol/l
0.12
93
721
395
3488
1.19
2.21
2.1
2.1
221.20
186.83
u/l
0.24
377
3319
380
3345
1.20
2.20
3.4
3.1
—
—
—
0
0
65
452
1.46
2.20
2.1
1.9
9.99
7.43
iu/ml
0.29
22
109
79
570
1.41
2.20
1.1
1.1
—
—
—
0
0
1088
10513
1.28
2.19
5.3
5.0
1.51
1.48
mmol/l
1.25
1019
9812
35
212
1.67
2.15
2.2
3.8
31.05
26.10
mg/l
0.28
22
148
22
117
1.90
2.07
3.2
2.7
—
—
—
0
0
81
594
1.39
2.07
1.8
1.8
—
—
—
0
0
56
385
1.48
2.02
1.0
1.1
—
—
—
0
0
691
6429
1.17
2.00
4.9
5.0
6.64
6.60
mmol/l
0.18
664
6132
159
1293
1.26
1.98
1.4
1.3
—
—
—
0
0
33
202
1.65
1.97
1.2
1.1
24.94
18.02
au/ml
—
9
60
613
5656
1.17
1.96
7.3
6.2
0.04
0.04
e9/l
0.09
550
4878
100
767
1.33
1.94
1.4
1.3
80.94
209.73
u/ml
2.41
90
707
22
120
1.85
1.93
1.4
1.5
24.58
24.97
ng/l
0.03
22
120
138
1107
1.28
1.92
4.9
3.2
7.38
7.38
ph
0.05
94
633
134
1072
1.28
1.91
4.6
3.2
1.89
1.96
mmol/l
0.08
118
917
90
681
1.35
1.91
3.4
3.6
4.42
4.54
pmol/l
0.51
84
603
19
99
1.93
1.91
1.4
1.3
—
—
—
0
0
611
5646
1.16
1.89
7.3
6.2
0.58
0.58
e9/l
0.36
547
4870
259
2231
1.20
1.88
2.5
2.9
2.45
2.45
mmol/l
0.08
234
2018
16
79
2.04
1.85
2.9
2.0
18.15
19.23
nmol/l
0.16
16
73
219
1859
1.22
1.85
3.4
3.2
0.75
0.76
ug/l
0.14
149
1185
630
5843
1.16
1.84
7.6
6.4
0.18
0.19
e9/l
0.95
572
5121
7
23
3.05
1.80
1.9
1.8
—
—
—
0
0
117
931
1.28
1.75
3.0
3.0
66.18
66.84
g/l
0.57
112
862
549
5057
1.15
1.73
16.9
14.4
1.26
1.24
inr
0.33
478
4204
69
511
1.37
1.70
4.5
4.2
36.88
36.92
°c
0.32
69
506
504
4618
1.15
1.70
1.9
1.9
1.29
1.36
mmol/l
1.31
405
3951
72
542
1.35
1.61
4.9
3.4
1.02
1.02
ratio
0.93
67
496
186
1577
1.21
1.60
1.6
1.3
569.30
508.48
titre
0.14
43
330
26
159
1.65
1.60
1.9
2.2
0.93
0.89
%
0.10
16
108
326
2904
1.17
1.59
2.8
2.7
346.58
339.37
umol/l
0.59
290
2572
189
1607
1.21
1.58
1.2
1.2
—
—
—
0
0
18
99
1.83
1.57
1.4
1.3
4.67
6.89
g/l
—
8
73
18
99
1.83
1.57
1.4
1.3
0.35
0.37
g/l
—
7
72
18
99
1.83
1.57
1.4
1.3
2.79
2.98
g/l
—
8
72
32
480
0.66
1.56
1.9
1.6
0.34
0.37
mg/l
0.09
17
234
18
101
1.79
1.49
1.3
2.1
6.85
5.91
umol/l
—
10
73
5
16
3.13
1.44
3.2
3.1
—
—
—
0
0
96
767
1.27
1.43
2.8
2.5
29.74
20.90
au/ml
0.28
12
78
9
39
2.32
1.43
23.7
34.9
97.67
124.06
ug/l
—
9
34
570
5319
1.13
1.39
7.3
6.3
28.37
27.73
%
0.64
539
5070
373
3391
1.14
1.36
7.0
6.5
—
—
—
0
0
5
17
2.95
1.36
1.4
1.6
0.38
0.48
e9/l
—
5
17
34
232
1.48
1.35
2.2
1.4
—
—
—
0
0
174
1492
1.19
1.35
6.0
5.3
1.00
1.02
mmol/l
0.37
162
1376
31
208
1.50
1.33
2.2
4.5
2.35
2.52
mmol/l
0.12
21
140
27
176
1.55
1.32
1.3
1.5
—
—
—
0
0
53
395
1.36
1.31
1.2
1.2
—
—
—
0
0
9
174
0.51
1.29
1.1
1.0
—
—
—
0
0
208
1820
1.17
1.28
1.8
1.7
1277.29
1185.67
nmol/l
0.66
166
1373
38
269
1.43
1.27
1.9
1.3
10.10
9.82
u/l
0.05
32
220
18
107
1.69
1.26
1.3
1.2
—
—
—
0
0
329
2984
1.14
1.24
1.5
1.4
—
—
—
0
0
87
702
1.26
1.23
1.4
1.3
66.43
44.11
au/ml
—
7
55
18
108
1.68
1.22
2.4
1.6
410.54
340.81
mu/l
0.49
13
88
32
221
1.46
1.22
2.2
3.7
—
—
—
0
0
105
867
1.23
1.21
3.8
3.6
82.74
83.32
ng/l
0.03
89
762
23
148
1.56
1.20
6.1
2.7
—
—
—
0
0
231
2048
1.16
1.20
1.2
1.3
9.67
12.03
u/ml
0.24
94
789
96
787
1.24
1.18
1.5
1.3
—
—
—
0
0
43
316
1.37
1.18
2.3
3.4
5.75
2.14
index
0.38
24
165
21
319
0.65
1.14
1.1
1.1
—
—
—
0
0
13
73
1.79
1.11
1.2
1.2
—
—
—
0
0
521
4887
1.11
1.10
2.1
2.1
95.76
96.13
pmol/l
0.07
275
2608
350
3210
1.13
1.10
1.6
1.7
21.45
20.44
nmol/l
0.57
304
2730
17
104
1.64
1.09
3.5
5.8
27.92
46.26
u/ml
—
6
40
84
1019
0.81
1.07
3.9
4.0
7.34
7.36
ph
0.23
64
744
41
305
1.36
1.06
1.1
1.2
—
—
—
0
0
552
5202
1.11
1.06
7.4
6.4
9.05
8.78
%
1.18
520
4904
10
52
1.93
1.06
1.2
1.7
—
45.76
—
0
5
18
113
1.60
1.06
1.6
2.3
—
—
—
0
0
72
580
1.26
1.06
1.6
1.3
23.71
31.03
iu/l
1.01
62
501
7
35
2.01
1.00
1.0
1.3
—
—
—
0
0
18
115
1.57
1.00
2.0
1.5
—
—
—
0
0
550
5197
1.10
0.99
7.4
6.3
2.66
2.82
%
1.17
518
4895
162
1422
1.16
0.98
1.6
1.4
—
—
—
0
0
32
232
1.39
0.98
2.0
1.8
178.41
198.39
pmol/l
0.48
32
220
116
991
1.19
0.98
1.4
1.4
—
—
—
0
0
21
140
1.51
0.98
1.3
1.3
—
—
—
0
0
0
29
0.00
0.97
0.0
1.1
—
—
—
0
0
0
31
0.00
0.96
0.0
1.2
—
37.78
—
0
16
150
1315
1.16
0.93
3.6
2.7
5.69
7.61
umol/l
2.33
122
1161
213
1917
1.13
0.91
3.3
2.9
0.78
1.00
e6/l
1.05
131
1022
212
1908
1.13
0.91
2.8
3.3
0.83
0.82
mmol/l
0.43
192
1805
552
5233
1.10
0.91
7.4
6.2
56.97
57.34
%
0.30
535
5013
6
29
2.07
0.89
1.7
1.2
58.95
54.91
%
—
6
24
64
522
1.24
0.88
1.9
2.1
—
—
—
0
0
548
5202
1.10
0.87
7.5
6.3
0.68
0.68
%
0.04
514
4894
6
30
2.00
0.87
1.3
1.4
—
—
—
0
0
35
264
1.34
0.86
2.3
1.5
1018.88
622.60
e6/l
0.19
25
205
8
46
1.74
0.82
1.1
1.4
185.63
175.84
mmol/24h
—
8
46
49
391
1.26
0.82
1.7
1.6
11.46
13.11
u/ml
0.10
11
96
6
32
1.88
0.82
1.5
2.4
7.66
9.34
mg/l
—
6
25
6
32
1.88
0.82
1.2
1.4
2.22
3.67
mmol/l
—
6
26
24
172
1.40
0.81
1.1
1.2
—
—
—
0
0
101
871
1.17
0.80
3.8
2.8
11.09
10.58
g/l
0.42
90
804
205
1859
1.12
0.79
2.8
2.5
13.94
13.00
umol/l
1.21
187
1735
6
33
1.82
0.79
1.0
1.6
81.83
87.48
nmol/24h
—
6
33
30
395
0.75
0.79
1.7
2.3
479.99
386.41
ug/l
0.12
30
374
12
74
1.63
0.78
1.1
1.0
—
—
—
0
0
34
261
1.31
0.77
2.2
1.4
6.74
14.44
e6/l
0.63
19
197
137
1214
1.14
0.76
1.7
1.6
—
—
—
0
0
192
1739
1.12
0.76
2.0
1.8
—
—
—
0
0
29
218
1.34
0.75
1.1
1.1
2.21
1.45
u/ml
0.23
17
118
101
876
1.17
0.75
1.3
1.2
—
—
—
0
0
123
1084
1.15
0.74
1.3
1.4
—
—
—
0
0
105
1201
0.86
0.74
2.1
2.1
3.19
3.51
ratio
2.44
80
959
38
298
1.28
0.74
1.9
1.8
51.82
40.93
nmol/l
0.98
38
287
42
334
1.27
0.74
1.5
1.4
269.30
294.84
ug/g
0.36
28
195
159
1427
1.13
0.74
3.3
3.1
4.03
5.06
e9/l
1.45
144
1249
270
2500
1.10
0.72
2.0
1.7
1.16
1.17
mg/l
0.02
212
1936
5
26
1.93
0.70
1.4
1.3
—
—
—
0
0
11
166
0.66
0.64
1.1
1.1
—
—
—
0
0
10
154
0.65
0.64
2.3
1.6
—
—
—
0
0
10
154
0.65
0.64
2.3
1.6
—
—
—
0
0
10
154
0.65
0.64
2.3
1.6
—
—
—
0
0
10
154
0.65
0.64
2.3
1.6
—
—
—
0
0
45
369
1.23
0.63
4.1
3.8
44.32
64.34
mg/l
0.61
39
317
165
1501
1.11
0.63
1.3
1.3
—
—
—
0
0
188
1723
1.11
0.62
2.8
2.5
2.38
2.32
g/l
0.78
172
1595
67
573
1.18
0.62
1.1
1.1
—
1.06
—
0
5
14
199
0.70
0.61
1.1
1.2
—
—
—
0
0
762
7403
1.08
0.61
3.6
3.3
44.25
49.35
u/l
1.04
714
7006
0
20
0.00
0.60
0.0
1.8
—
—
—
0
0
111
989
1.13
0.60
1.4
1.4
—
—
—
0
0
121
1086
1.13
0.59
2.0
2.3
0.20
0.21
g/l
1.10
113
1010
17
123
1.39
0.58
2.2
2.7
1.48
0.86
g/24h
0.30
11
75
15
106
1.42
0.57
1.4
1.2
0.11
0.79
u/ml
—
10
51
11
73
1.51
0.56
2.0
1.7
90.10
96.60
ng/l
0.17
11
73
5
88
0.57
0.56
2.8
2.5
19.00
31.91
mg/l
—
5
66
17
124
1.38
0.56
3.5
1.6
—
—
—
0
0
23
177
1.31
0.55
1.4
1.6
0.37
0.81
g/l
2.48
12
142
6
38
1.58
0.54
1.5
2.8
15.63
17.12
ug/l
—
6
33
40
332
1.21
0.52
4.3
3.8
1.27
2.53
ratio
2.78
19
190
44
369
1.20
0.52
4.1
3.9
31.79
43.55
mg/l
0.66
38
316
32
390
0.82
0.50
4.8
3.8
24.85
25.12
mmol/l
0.29
32
362
6
41
1.47
0.50
1.2
1.1
—
11.33
u/ml
—
0
6
79
699
1.14
0.50
2.0
1.9
1.23
1.43
g/l
0.49
71
646
255
2707
0.93
0.49
2.4
2.4
—
—
—
0
0
25
311
0.80
0.48
1.4
1.2
—
1347.78
—
0
9
10
68
1.47
0.47
1.8
3.9
0.80
0.85
index
—
10
68
7
49
1.43
0.46
1.1
1.3
—
—
—
0
0
31
255
1.22
0.46
1.4
1.6
—
—
—
0
0
188
1754
1.08
0.46
3.6
3.1
3.15
2.64
e6/l
0.26
106
855
5
31
1.62
0.43
2.2
1.6
17.40
14.60
pmol/l
—
5
26
122
1326
0.91
0.42
5.5
7.9
4.86
5.10
kpa
2.26
117
1275
65
732
0.88
0.42
5.0
9.6
1.38
1.28
%
0.40
65
727
6
92
0.65
0.42
1.0
1.1
288.33
282.75
mg/l
—
6
81
6
94
0.64
0.42
1.3
1.1
—
—
—
0
0
5
32
1.56
0.42
1.8
1.2
17.04
31.27
nmol/l
—
5
24
5
32
1.56
0.42
1.4
1.2
—
—
—
0
0
8
58
1.38
0.41
1.8
3.2
1499.62
1013.24
u/ml
—
8
58
0
15
0.00
0.41
0.0
1.1
—
42.00
—
0
5
0
15
0.00
0.41
0.0
1.0
—
0.28
—
0
5
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
116
1066
1.10
0.40
2.4
2.1
0.03
0.02
estimate
0.05
35
206
16
205
0.78
0.40
1.1
1.1
—
—
—
0
0
16
205
0.78
0.40
1.1
1.1
—
—
—
0
0
171
1601
1.08
0.39
2.1
2.0
—
—
—
0
0
60
532
1.13
0.39
2.2
2.2
0.11
1.54
estimate
0.45
27
163
10
137
0.73
0.39
1.7
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
4.1
—
—
—
0
0
0
19
0.00
0.39
0.0
4.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.6
—
—
—
0
0
22
178
1.24
0.39
1.0
1.1
0.16
1.58
u/ml
—
7
72
169
1583
1.08
0.39
3.0
2.5
24.71
22.75
%
1.27
156
1477
104
954
1.10
0.38
2.8
2.7
76.36
68.64
e9/l
1.04
71
697
16
203
0.79
0.38
1.4
1.4
—
—
—
0
0
77
696
1.11
0.37
3.6
3.5
7.42
7.42
ph
0.45
62
587
86
783
1.11
0.37
1.7
1.7
—
—
—
0
0
34
290
1.18
0.37
1.5
1.9
2404.03
4709.77
u/l
—
10
112
32
272
1.18
0.36
1.0
1.1
0.82
6.11
eliau/ml
—
5
31
40
347
1.16
0.36
18.8
10.2
—
—
—
0
0
126
1171
1.08
0.36
3.1
4.3
34.80
17.42
ug/l
0.23
102
962
9
126
0.71
0.35
1.0
1.2
—
—
—
0
0
22
181
1.22
0.34
1.0
1.0
2.80
3.16
u/ml
—
10
89
6
86
0.70
0.33
1.3
1.1
—
—
—
0
0
6
87
0.69
0.33
2.0
1.5
—
—
—
0
0
36
313
1.15
0.32
1.4
1.2
2.05
2.33
u/ml
—
6
31
18
146
1.24
0.32
1.0
1.1
1.16
1.99
eliau/ml
—
8
61
42
370
1.14
0.32
2.5
3.2
319.23
280.04
mg/l
0.10
22
156
12
92
1.31
0.32
1.2
1.2
—
—
—
0
0
37
324
1.15
0.31
2.5
2.0
3.11
4.24
iu/l
0.74
19
129
7
55
1.27
0.30
2.9
1.5
—
—
—
0
0
36
316
1.14
0.29
1.4
1.3
4.33
10.86
u/ml
—
7
51
31
269
1.16
0.29
1.7
2.1
131.52
128.48
g/l
0.28
25
211
86
797
1.08
0.28
1.3
1.2
125.40
137.31
u/ml
0.10
27
316
80
860
0.93
0.25
3.3
3.1
124.36
201.45
ng/l
2.64
74
795
9
73
1.23
0.25
1.9
1.4
74.11
77.59
umol/l
—
9
73
25
287
0.87
0.25
2.0
1.6
4890.27
13858.37
e6/l
2.09
15
200
83
887
0.93
0.23
1.6
1.8
3.35
3.56
mmol/l
1.41
57
647
5
38
1.32
0.23
2.8
3.2
—
—
—
0
0
126
1326
0.94
0.23
5.7
7.9
7.44
7.42
ph
3.04
77
751
124
1177
1.06
0.22
1.8
1.6
—
—
—
0
0
18
153
1.18
0.22
1.3
1.4
0.57
0.64
nmol/l
0.37
18
146
21
242
0.87
0.22
1.4
1.8
—
—
—
0
0
7
95
0.74
0.22
1.1
1.2
96.00
110.48
pmol/l
—
7
95
13
107
1.22
0.21
3.1
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
3.1
—
11.82
—
0
11
0
10
0.00
0.21
0.0
8.2
—
8.40
—
0
10
0
10
0.00
0.21
0.0
1.0
—
19.78
—
0
10
0
10
0.00
0.21
0.0
4.1
—
55.50
—
0
10
0
10
0.00
0.21
0.0
1.1
—
224.00
—
0
10
0
12
0.00
0.21
0.0
1.0
—
173.20
—
0
5
84
790
1.07
0.21
1.6
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
20.17
—
0
6
0
13
0.00
0.21
0.0
1.4
—
1.41
—
0
6
0
13
0.00
0.21
0.0
1.0
—
64.00
—
0
13
14
166
0.84
0.20
1.0
1.0
0.42
2.79
u/ml
—
5
77
10
123
0.81
0.20
1.0
1.1
—
—
—
0
0
6
50
1.20
0.19
1.3
1.3
126.28
163.51
pmol/l
—
6
50
44
404
1.09
0.19
2.0
2.7
—
—
—
0
0
6
51
1.18
0.19
1.0
1.1
1531.83
1700.51
miu/ml
—
6
51
19
165
1.15
0.19
3.5
2.4
—
—
—
0
0
126
1317
0.95
0.19
5.3
7.9
1.53
0.99
mmol/l
1.12
110
1078
16
185
0.86
0.18
1.5
1.4
89.50
173.63
au/ml
—
5
50
46
497
0.92
0.18
4.2
3.6
—
—
—
0
0
27
299
0.90
0.17
1.2
1.3
—
—
—
0
0
93
885
1.05
0.17
2.6
2.3
6.18
7.52
ug/l
0.35
87
785
15
129
1.16
0.17
1.3
1.3
—
—
nmol/l
—
0
0
5
69
0.72
0.17
1.4
1.7
5.60
8.45
ug/l
—
5
59
12
101
1.19
0.16
2.2
2.6
—
33.16
—
0
11
14
120
1.17
0.16
1.1
1.2
—
—
—
0
0
393
3858
1.03
0.16
3.7
3.3
32.56
31.57
u/l
0.10
373
3654
31
283
1.10
0.16
1.7
1.6
1053.72
927.37
mu/l
0.34
25
228
385
3779
1.03
0.15
3.0
3.2
7.38
7.55
mmol/l
0.36
342
3241
10
83
1.21
0.15
1.0
1.2
39.60
35.63
mg/l
—
5
70
519
5117
1.02
0.15
2.9
2.7
—
—
estimate
—
0
0
91
950
0.95
0.14
5.8
8.5
—
—
—
0
0
371
3647
1.02
0.13
3.8
3.8
5.05
7.65
mg/mmol
1.32
225
2245
14
122
1.15
0.13
1.1
1.1
—
—
—
0
0
8
98
0.82
0.13
1.1
1.2
—
—
—
0
0
378
3719
1.02
0.13
7.6
6.1
—
—
—
0
0
13
113
1.15
0.13
1.5
1.4
6.61
6.40
mmol/l
0.20
13
104
22
242
0.91
0.13
3.4
3.3
51.25
57.84
%
1.59
22
242
40
427
0.93
0.13
1.2
1.2
0.89
0.91
g/l
0.29
40
427
19
171
1.11
0.12
1.3
1.2
—
—
—
0
0
20
181
1.11
0.12
1.0
1.0
0.64
1.62
u/ml
0.92
11
87
28
302
0.93
0.11
1.3
1.2
—
—
—
0
0
29
312
0.93
0.11
1.5
1.6
—
—
—
0
0
219
2145
1.03
0.11
3.6
4.0
542.53
372.46
ng/l
0.16
169
1649
112
1085
1.04
0.11
2.4
2.4
35.99
43.40
u/l
0.76
97
921
15
134
1.12
0.11
1.7
1.3
0.17
0.31
nmol/l
0.54
15
105
15
167
0.90
0.10
2.1
1.9
—
—
—
0
0
40
423
0.94
0.10
3.1
1.8
19.57
20.76
s
1.44
35
383
91
880
1.04
0.10
2.9
2.6
6.08
6.02
ph
0.17
74
591
14
155
0.90
0.09
1.9
1.3
—
—
—
0
0
6
54
1.11
0.09
1.0
1.3
33.67
29.15
umol/l
—
6
48
21
226
0.93
0.08
1.3
1.1
—
—
—
0
0
5
63
0.79
0.08
1.6
2.7
16.16
16.11
%
—
5
63
5
63
0.79
0.08
1.0
1.2
135.40
139.56
nmol/l
—
5
63
39
408
0.95
0.07
1.1
1.1
1.66
1.55
g/l
1.92
39
408
14
153
0.91
0.07
1.0
1.2
—
—
—
0
0
12
132
0.91
0.06
1.1
1.2
—
—
—
0
0
9
100
0.90
0.06
5.9
4.6
—
—
—
0
0
30
315
0.95
0.06
1.2
1.3
—
—
—
0
0
149
1466
1.02
0.06
1.8
1.6
—
—
—
0
0
311
3080
1.01
0.06
4.5
4.4
—
—
—
0
0
126
1238
1.02
0.05
3.3
2.6
1.79
1.81
%
0.08
112
1110
12
131
0.92
0.05
2.6
1.8
18.32
22.02
ug/l
0.29
12
126
20
188
1.06
0.05
1.6
1.6
—
—
—
0
0
10
90
1.11
0.05
1.6
1.2
—
—
—
0
0
19
202
0.94
0.05
1.9
1.7
—
—
—
0
0
10
110
0.91
0.05
1.2
1.1
—
—
—
0
0
12
110
1.09
0.05
2.8
2.3
—
—
—
0
0
360
3573
1.01
0.05
3.0
3.2
34.93
44.31
mg/l
0.59
223
2250
33
343
0.96
0.05
1.4
1.3
43.43
220.85
miu/ml
10.12
14
167
105
1033
1.02
0.04
2.9
7.3
1.38
1.33
mmol/l
0.28
100
1014
10
109
0.92
0.04
2.1
1.5
—
—
—
0
0
24
248
0.97
0.02
1.5
1.4
—
—
—
0
0
33
338
0.98
0.01
1.4
1.5
—
—
—
0
0
13
123
1.06
0.01
1.5
1.6
71.25
60.79
%
—
8
75
356
3568
1.00
0.01
2.6
2.4
—
—
—
0
0
21
206
1.02
0.00
2.3
2.4
50.84
104.17
ug/min
0.87
13
125
34
336
1.01
0.00
1.4
1.5
—
—
—
0
0
14
142
0.99
0.00
1.9
1.6
—
—
—
0
0
34
338
1.01
0.00
1.4
1.5
—
—
—
0
0
50
502
1.00
0.00
1.5
1.8
1.49
1.60
g/l
0.36
40
439
293
2934
1.00
0.00
2.3
2.2
2.84
2.85
mg/l
0.01
248
2510
10
103
0.97
0.00
2.3
1.7
—
—
—
0
0
11
107
1.03
0.00
2.5
2.4
—
—
—
0
0
14
137
1.02
0.00
1.6
1.5
—
—
—
0
0
20
197
1.02
0.00
3.1
3.4
3.86
4.23
e9/l
0.34
20
197
34
337
1.01
0.00
1.4
1.5
—
—
—
0
0
11
105
1.05
0.00
2.1
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.4
5.53
6.29
mmol/l
—
5
50
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
69
0.87
-0.00
1.5
2.6
7.33
8.22
mmol/l
—
6
69
8
80
1.00
-0.00
1.4
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
305.98
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
0.16
—
0
7
6
64
0.94
-0.00
1.2
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.3
—
0.18
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
6
60
1.00
-0.00
1.3
3.0
1848.33
1791.13
ml
—
6
53
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
8.60
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
-0.00
20.7
14.0
0.63
0.65
mmol/l
—
6
58
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
31.15
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
0.03
—
0
8
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
365.13
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
91.50
—
0
6
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_PERIPHRETINADEGEN and mortality.

Females

Parameter HR [95% CI] p-value
H7_PERIPHRETINADEGEN 0.789 [0.7, 0.88] < 0.001
Birth year 0.995 [0.99, 1.0] 0.27

During the follow-up period (1.1.1998 — 31.12.2019), 516 out of 4493 females with H7_PERIPHRETINADEGEN died.

Males

Parameter HR [95% CI] p-value
H7_PERIPHRETINADEGEN 0.794 [0.7, 0.9] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 436 out of 2702 males with H7_PERIPHRETINADEGEN died.

Mortality risk

Mortality risk for people of age

years, who have H7_PERIPHRETINADEGEN.

N-year risk Females Males
1 0.07% 0.126%
5 0.405% 0.914%
10 1.083% 2.273%
15 2.237% 4.398%
20 4.093% 7.697%

Relationships between endpoints

↥

Index endpoint: H7_PERIPHRETINADEGEN – Peripheral retinal degeneration

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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