Mandibular hypoplasia

K11_MANDIBULAR_HYPOPL

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 K07.04
  • Hospital discharge: ICD-10 K07.04
  • Cause of death: ICD-10 K07.04

3 out of 7 registries used, show all original rules.

258

4. Check minimum number of events

None

258

5. Include endpoints

None

258

6. Filter based on genotype QC (FinnGen only)

241

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3002 1649 1349
Only index persons 2772 1531 1241
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.04
Only index persons 0.05 0.06 0.05
Median age at first event (years)
Whole population 16.04 18.26 13.29
Only index persons 17.29 20.04 13.90

-FinnGen-

Key figures

All Female Male
Number of individuals 241 175 66
Unadjusted period prevalence (%) 0.05 0.06 0.03
Median age at first event (years) 37.68 36.44 40.97

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
250
Matched controls
2500
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K07.04
ICD-10 Finland
Macrognathism (mandibular)(maxillary)
+∞
307.7
250
*
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
155.2
191.6
96
10
K07.13
ICD-10 Finland
Retrognaty, mandibular
90.0
187.6
102
19
K07.23
ICD-10 Finland
Deep bite
25.2
109.1
86
51
SBB10
NOMESCO Finland
Dental impressions
14.1
99.1
127
171
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
20.5
91.1
78
54
EB1MA
NOMESCO Finland
Cephalometry with X-ray
19.8
89.3
78
56
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
24.1
88.6
69
39
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
18.5
87.9
80
62
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
17.6
77.6
71
55
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
14.9
76.6
79
75
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
19.3
73.4
63
43
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
25.9
61.8
45
21
K07.20
ICD-10 Finland
Crossbite (anterior)(posterior)
27.1
60.2
43
19
SAA04
NOMESCO Finland
Special examination of mouth
11.0
58.3
73
90
K07.24
ICD-10 Finland
Open bite
27.0
57.5
41
18
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
17.3
53.3
47
33
SJC10
NOMESCO Finland
Orthodontic band in one tooth
13.5
53.2
55
51
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
13.9
47.9
48
42
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
10.6
43.4
53
62
K07.60
ICD-10 Finland
Snapping jaw
8.3
40.9
63
98
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
10.7
39.4
47
53
SJX20
NOMESCO Finland
Orthodontic treatment/control appointment
13.0
39.0
40
36
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
8.2
38.0
58
89
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
11.1
35.1
40
42
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
6.2
32.6
67
139
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
8.6
30.7
43
59
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
13.0
30.6
31
27
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
4.7
27.7
83
237
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
8.4
27.1
38
52
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
7.7
26.8
41
62
K07.4
ICD-10 Finland
Malocclusion, unspecified
9.6
26.4
33
39
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
7.7
25.0
38
57
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
+∞
23.3
22
*
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
48.1
21.9
26
6
K07.10
ICD-10 Finland
Asymmetry of jaw
120.1
20.9
22
*
EEC05
NOMESCO Finland
Le Fort I osteotomy
120.1
20.9
22
*
K07.22
ICD-10 Finland
Anomalies of dental arch relationship
44.1
19.9
24
6
SXC05
NOMESCO Finland
Other oral or dental procedure
4.3
18.4
55
153
WZC00
NOMESCO Finland
Treatment plan or consultation
3.2
17.9
137
694
SXB00
NOMESCO Finland
Removal of sutures from oral mucosa
5.4
17.7
38
80
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
5.5
17.2
36
74
SAA03
NOMESCO Finland
Extended examination of mouth
3.0
16.3
154
863
K07.0
ICD-10 Finland
Major anomalies of jaw size
170.2
15.7
16
*
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
60.5
15.0
17
*
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
27.0
14.9
20
8
SJC00
NOMESCO Finland
Bondable bracket or other fixed attachement
85.2
14.7
16
*
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
6.9
14.4
23
36
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.8
14.0
146
840
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
4.9
13.3
31
70
SJC40
NOMESCO Finland
Removal of fixed orthodontic appliance with at most 6 brackets
5.1
13.0
29
63
EBB10
NOMESCO Finland
Insertion of dental implant
18.6
12.7
19
11
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
73.7
12.7
14
*
EDC30
NOMESCO Finland
Genioplasty
+∞
12.6
12
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.8
12.4
42
126
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
39.7
12.3
15
*
SJX00
NOMESCO Finland
Reparation of orthodontic appliance by dentist
17.5
11.9
18
11
SJB10
NOMESCO Finland
Fitting of removable appliance incl. patient instructions, demanding
10.8
10.7
20
20
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
15.1
10.6
17
12
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
+∞
10.5
10
*
Z47.0
ICD-10 Finland
Follow-up care involving removal of fracture plate and other internal fixation device
41.9
10.1
12
*
K07.14
ICD-10 Finland
Retrognaty, maxillary
57.3
9.7
11
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.8
9.7
31
89
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
103.8
9.5
10
*
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
103.8
9.5
10
*
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
103.8
9.5
10
*
EBB15
NOMESCO Finland
Insertion of dental implant abutment
22.7
9.4
13
6
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
4.4
9.2
24
59
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
38.2
9.1
11
*
SJA02
NOMESCO Finland
Workplan for orthodontic treatment
38.2
9.1
11
*
K01.0
ICD-10 Finland
Embedded teeth
8.5
9.0
19
24
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
10.6
8.7
16
16
SPC20
NOMESCO Finland
Implant borne crown
28.6
8.6
11
*
5240A
ICD-9 Finland
Dentofacial anomalies, including malocclusion, Major anomalies of jaw size
93.1
8.5
9
*
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
2.7
8.2
49
206
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
34.6
8.1
10
*
ZXA10
NOMESCO Finland
Bilateral
2.6
8.0
54
241
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
46.5
7.8
9
*
4343
FHL
Lower jaw open osteotomy
82.4
7.5
8
*
EDC45
NOMESCO Finland
Reconstruction of mandible using bone graft
+∞
7.3
7
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
7.2
100
603
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
9.2
7.1
14
16
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
7.4
7.1
16
23
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
7.4
7.1
16
23
H04.10
ICD-10 Finland
Dry eye syndrome
2.7
7.0
41
169
P01BA02
ATC
hydroxychloroquine; oral
3.2
6.8
28
95
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
6.2
6.7
17
29
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
23.2
6.7
9
*
K07.27
ICD-10 Finland
Anomalies of dental arch relationship
8.2
6.7
14
18
L01BA01
ATC
methotrexate; systemic
7.2
6.6
15
22
K07.9
ICD-10 Finland
Dentofacial anomaly, unspecified
71.6
6.5
7
*
K07.00
ICD-10 Finland
Macrognatia (hyperplasia) of the upper jaw
+∞
6.3
6
*
EGC30
NOMESCO Finland
Prosthetic replacement of mandibular joint
+∞
6.3
6
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
6.2
93
572
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.4
6.0
22
69

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
107
611
2.31
9.32
3.9
3.4
0.00
0.00
estimate
0.50
37
233
162
1180
2.06
6.80
3.8
3.4
0.02
0.00
estimate
0.49
41
243
159
1171
1.98
6.22
3.8
3.3
0.00
0.00
estimate
0.50
40
243
130
899
1.93
6.08
3.6
3.0
0.00
0.02
estimate
0.68
33
210
159
1191
1.92
5.68
3.7
3.4
0.00
0.00
estimate
-0.00
38
229
213
1775
2.35
5.60
5.6
4.6
14.69
14.52
pmol/l
0.51
199
1651
132
946
1.84
5.27
3.6
3.1
6.44
6.19
ph
1.76
77
548
85
575
1.72
3.85
4.4
5.2
—
—
—
0
0
77
511
1.73
3.72
4.4
3.4
1.02
1.02
kg/l
0.53
45
336
9
17
5.45
3.54
1.9
1.4
—
—
—
0
0
108
812
1.58
3.10
3.1
3.7
22.33
60.07
e6/l
1.01
79
559
67
450
1.67
3.03
2.1
2.4
6.60
9.25
e6/l
0.49
61
413
131
1035
1.56
3.00
8.6
10.1
0.00
0.00
e9/l
0.75
118
843
228
2073
2.13
3.00
6.5
5.4
1.76
1.80
mu/l
0.20
215
1966
143
1166
1.53
2.74
7.2
6.9
0.50
0.54
e9/l
1.89
129
1019
220
1989
1.88
2.74
4.4
3.8
1.19
1.26
mmol/l
0.88
213
1880
146
1199
1.52
2.69
7.2
6.8
1.90
2.07
e9/l
0.83
132
1071
142
1166
1.50
2.57
7.3
6.9
0.04
0.04
e9/l
0.59
127
1016
146
1208
1.50
2.53
7.1
7.3
0.18
0.19
e9/l
0.14
132
1074
38
231
1.76
2.45
1.3
1.5
—
—
—
0
0
13
52
2.58
2.40
1.0
1.1
—
—
—
0
0
155
1308
1.49
2.37
8.0
10.4
3.66
3.94
e9/l
1.10
137
1143
40
250
1.71
2.34
1.6
1.6
—
—
—
0
0
78
584
1.49
2.14
2.4
3.1
0.23
0.31
e6/l
0.28
60
427
89
685
1.46
2.13
2.5
3.1
13.39
51.33
e6/l
2.14
70
521
38
241
1.68
2.12
1.5
1.4
—
—
—
0
0
29
171
1.79
2.08
1.5
1.8
—
—
—
0
0
241
2299
2.34
2.07
14.3
14.7
69.14
70.63
umol/l
0.81
241
2276
48
326
1.58
2.05
1.5
1.6
421.80
39262181.14
pmol/l
0.50
41
298
142
1202
1.42
1.98
3.5
3.3
68.24
86.14
ug/l
1.70
134
1149
6
157
0.37
1.97
1.3
1.4
—
—
—
0
0
31
190
1.72
1.96
1.5
1.9
0.00
0.08
estimate
—
8
38
5
11
4.61
1.95
1.0
1.5
—
—
—
0
0
104
841
1.41
1.85
5.7
6.8
1.21
1.22
mmol/l
0.34
98
788
26
158
1.72
1.70
2.2
2.4
6495.54
2695.06
u/l
0.36
11
63
114
947
1.37
1.69
5.6
7.6
1.22
1.22
mmol/l
0.07
100
831
52
376
1.48
1.67
2.6
2.4
95.76
82.72
ug/g
0.20
41
302
28
175
1.68
1.66
2.8
2.8
—
—
—
0
0
224
2097
1.66
1.65
5.0
4.5
1.52
1.48
mmol/l
0.64
217
1995
226
2121
1.68
1.64
5.4
4.9
2.79
2.81
mmol/l
0.21
219
2023
13
63
2.12
1.63
2.8
2.5
3.45
8.24
umol/l
—
8
46
35
235
1.57
1.58
1.7
1.6
1114.32
1205.35
nmol/l
0.27
25
185
8
33
2.47
1.55
1.3
1.1
—
—
—
0
0
178
1601
1.39
1.54
7.1
7.7
73.47
77.78
u/l
0.80
171
1519
224
2105
1.62
1.52
5.2
4.6
4.68
4.75
mmol/l
0.57
218
2012
63
482
1.41
1.51
1.6
1.6
21.21
21.42
nmol/l
0.04
57
422
10
45
2.27
1.48
1.2
1.3
3.40
5.80
u/ml
—
5
20
15
80
1.93
1.48
1.3
1.1
—
—
—
0
0
85
692
1.35
1.39
2.3
2.6
0.03
0.02
estimate
0.19
33
199
39
277
1.48
1.38
2.4
1.9
—
—
—
0
0
18
105
1.77
1.37
1.4
1.5
9.15
8.83
u/l
0.04
13
82
14
75
1.92
1.37
9.7
5.0
36.96
36.95
°c
0.13
14
75
5
17
2.98
1.36
1.0
1.4
—
—
—
0
0
35
245
1.50
1.33
1.7
1.4
—
—
—
0
0
82
668
1.34
1.33
2.3
3.3
2.36
2.36
mmol/l
0.08
77
625
19
114
1.72
1.32
1.6
1.9
3.54
4.57
iu/ml
—
8
28
8
34
2.40
1.30
2.6
1.3
298.13
315.56
mu/l
—
8
25
5
18
2.81
1.29
1.0
1.1
2705.20
1520.56
miu/ml
—
5
18
21
131
1.66
1.28
1.2
1.2
—
—
—
0
0
64
505
1.36
1.27
2.7
2.2
2.98
2.74
mg/l
0.34
59
441
25
164
1.58
1.26
4.2
5.7
0.40
0.55
%
—
5
44
15
85
1.81
1.26
6.5
5.3
—
—
—
0
0
46
345
1.41
1.23
1.8
1.6
—
—
—
0
0
8
37
2.20
1.22
1.5
1.4
—
—
—
0
0
82
683
1.30
1.11
1.5
1.4
0.91
1.28
u/ml
0.47
30
175
101
867
1.28
1.08
2.0
1.9
—
—
—
0
0
71
583
1.30
1.07
3.3
4.1
7.39
7.40
ph
0.65
52
397
28
197
1.47
1.05
3.6
3.0
10.52
9.96
g/l
0.40
28
189
213
2017
1.38
1.01
4.6
4.2
5.63
5.72
mmol/l
0.53
208
1901
36
269
1.40
1.00
1.6
2.4
29.79
29.00
s
0.30
36
264
132
1180
1.25
0.98
4.8
4.6
6.18
6.35
mmol/l
0.48
127
1090
64
525
1.29
0.97
1.7
1.8
—
—
—
0
0
7
37
1.92
0.95
1.4
1.0
—
—
—
0
0
15
94
1.63
0.93
13.1
7.9
23.29
24.79
mmol/l
1.07
15
88
6
28
2.17
0.92
1.0
1.3
—
—
—
0
0
205
1941
1.31
0.88
5.4
5.1
36.56
37.98
mmol/mol
2.09
198
1867
8
43
1.89
0.88
1.1
1.0
—
—
—
0
0
6
30
2.02
0.87
1.0
1.3
—
—
—
0
0
120
1072
1.23
0.87
7.0
6.8
0.77
0.68
%
1.30
114
1017
121
1082
1.23
0.86
7.1
6.8
8.25
8.37
%
0.22
115
1035
8
46
1.76
0.83
1.5
2.3
—
—
—
0
0
78
669
1.24
0.82
4.9
6.4
—
—
—
0
0
120
1077
1.22
0.82
7.0
6.7
3.25
2.85
%
0.90
114
1024
0
25
0.00
0.79
0.0
4.4
—
11.63
—
0
25
92
806
1.22
0.79
2.1
1.9
97.03
96.65
pmol/l
0.03
53
424
0
26
0.00
0.79
0.0
20.2
—
1508.65
—
0
26
68
579
1.24
0.76
2.1
2.9
—
—
—
0
0
72
617
1.23
0.76
1.5
1.5
2.33
2.06
g/l
0.66
50
386
237
2306
1.53
0.74
11.7
10.6
25.30
26.42
u/l
0.41
232
2264
9
55
1.66
0.74
6.2
7.7
—
—
—
0
0
9
56
1.63
0.73
1.3
1.8
—
—
—
0
0
20
143
1.43
0.72
2.0
1.8
—
—
—
0
0
50
413
1.26
0.72
1.9
1.9
—
—
—
0
0
123
1117
1.20
0.72
7.0
6.7
30.21
29.89
%
0.12
117
1077
5
26
1.94
0.71
2.4
3.0
1414.00
1462.55
e6/l
—
5
20
236
2297
1.49
0.70
10.9
10.7
—
—
—
0
0
20
271
0.72
0.70
1.1
1.2
—
—
—
0
0
66
565
1.23
0.70
2.2
2.1
133.85
165.16
u/l
0.42
66
541
31
241
1.33
0.70
2.9
2.8
0.55
0.71
ug/l
1.35
21
131
47
387
1.26
0.70
2.2
2.5
522.67
552.08
mosm/kgh2o
0.35
40
343
14
94
1.52
0.68
1.7
3.0
21.67
21.68
s
—
9
85
74
648
1.20
0.63
2.1
2.1
—
—
—
0
0
77
677
1.20
0.63
2.5
3.1
26.72
21.32
ng/l
0.14
46
375
57
488
1.22
0.61
1.6
1.3
14.00
23.01
iu/ml
1.24
20
143
34
274
1.28
0.61
1.5
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
1.25
—
0
15
207
1988
1.24
0.60
18.1
16.0
332.76
333.06
g/l
0.20
207
1983
0
21
0.00
0.60
0.0
1.8
—
10.43
—
0
21
21
158
1.36
0.59
1.0
1.2
—
—
—
0
0
10
64
1.59
0.59
1.6
1.3
—
—
—
0
0
36
436
0.80
0.59
1.4
1.6
—
—
—
0
0
68
595
1.20
0.58
2.6
2.4
—
—
—
0
0
14
98
1.45
0.58
12.4
10.6
94.78
93.86
%
0.38
14
98
43
360
1.23
0.57
1.5
1.5
608.00
585.85
titre
—
5
82
112
1025
1.17
0.56
2.3
2.6
—
—
estimate
—
0
0
6
37
1.64
0.56
1.0
2.4
6.48
6.99
pmol/l
—
6
37
6
38
1.59
0.54
4.5
3.6
3.74
4.76
e9/l
—
6
38
15
108
1.41
0.54
1.1
1.1
1.49
1.56
g/l
0.62
15
108
25
310
0.78
0.50
1.3
1.4
—
—
—
0
0
15
110
1.39
0.50
1.2
1.1
0.86
0.87
g/l
0.03
15
110
28
227
1.26
0.49
9.2
7.5
105.25
104.26
mmol/l
0.52
28
227
21
165
1.30
0.46
2.2
1.8
1.33
1.39
g/l
0.10
21
158
5
85
0.58
0.46
19.4
8.5
15.68
16.14
%
—
5
80
80
727
1.15
0.43
7.4
6.6
—
—
—
0
0
5
31
1.63
0.43
1.2
2.8
—
—
—
0
0
10
70
1.45
0.42
1.2
1.1
0.02
0.74
u/ml
—
5
38
20
159
1.28
0.41
1.4
1.3
—
29.26
—
0
10
5
33
1.53
0.41
1.8
1.9
—
—
—
0
0
5
33
1.53
0.41
1.8
1.9
—
—
—
0
0
5
33
1.53
0.41
1.8
1.9
—
—
—
0
0
5
33
1.53
0.41
1.8
1.9
—
—
—
0
0
26
214
1.24
0.41
1.5
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
3.5
—
—
—
0
0
0
18
0.00
0.40
0.0
2.7
—
3.99
—
0
18
0
18
0.00
0.40
0.0
2.7
—
105.61
—
0
18
0
18
0.00
0.40
0.0
1.2
—
152.41
—
0
18
0
18
0.00
0.40
0.0
1.1
—
220.30
—
0
18
0
18
0.00
0.40
0.0
2.7
—
1.18
—
0
18
86
931
0.88
0.38
1.9
1.9
1.26
1.38
mmol/l
0.66
78
820
50
447
1.15
0.34
1.5
1.3
1.10
8.18
u/ml
2.80
32
184
6
45
1.34
0.34
2.8
2.3
7.41
7.42
ph
—
6
45
6
46
1.31
0.33
1.0
1.1
—
—
—
0
0
7
57
1.23
0.29
3.0
3.1
24.11
24.12
mmol/l
—
7
57
26
224
1.18
0.28
1.3
1.6
1056.31
953.90
mu/l
0.32
20
186
8
62
1.30
0.28
1.1
2.0
1.88
13.59
e6/l
—
8
46
30
341
0.86
0.27
2.2
3.2
449.17
330.29
ng/l
0.10
23
216
8
64
1.26
0.27
1.1
2.0
327.63
162.61
e6/l
—
8
51
21
178
1.20
0.27
1.8
1.9
5.89
6.12
ph
0.62
14
109
23
266
0.85
0.26
1.9
1.7
3.49
3.34
mmol/l
0.29
18
188
11
87
1.28
0.24
2.1
2.3
—
—
—
0
0
6
82
0.73
0.24
1.3
1.2
—
—
—
0
0
6
85
0.70
0.24
1.3
1.4
—
3.49
—
0
10
12
97
1.25
0.23
2.6
2.8
—
—
—
0
0
20
172
1.18
0.23
10.4
8.7
0.50
1.16
mmol/l
0.33
15
142
10
124
0.80
0.22
1.5
1.4
0.26
0.25
mg/l
—
5
50
104
993
1.08
0.22
2.8
2.7
—
—
—
0
0
20
173
1.17
0.21
10.4
8.7
7.44
7.42
ph
0.73
15
103
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
30
333
0.89
0.20
2.6
3.1
2.27
3.15
e6/l
0.20
13
154
224
2209
1.13
0.20
12.7
12.1
21.98
20.12
mg/l
0.27
182
1737
16
137
1.18
0.19
2.6
4.6
4.96
5.10
kpa
0.35
16
129
6
52
1.16
0.19
1.2
2.2
—
—
—
0
0
18
156
1.17
0.19
11.2
9.1
96.22
95.98
%
0.09
18
151
31
281
1.12
0.18
1.7
1.9
—
—
—
0
0
15
129
1.17
0.17
2.5
6.7
24.33
24.22
mmol/l
0.06
15
129
8
71
1.13
0.16
4.0
3.9
10.31
8.87
kpa
—
8
66
13
151
0.85
0.16
1.0
1.1
—
—
—
0
0
53
499
1.08
0.15
1.8
1.9
0.94
0.92
mg/l
0.03
39
383
9
78
1.16
0.15
2.3
1.5
—
—
—
0
0
18
160
1.13
0.14
1.1
1.1
—
—
—
0
0
8
97
0.82
0.14
2.6
1.2
—
—
—
0
0
10
85
1.18
0.12
1.6
1.7
—
—
—
0
0
13
147
0.88
0.12
1.6
3.8
64.29
72.46
e9/l
—
7
105
23
250
0.91
0.11
1.2
1.2
—
—
—
0
0
10
86
1.17
0.11
1.0
1.2
—
—
—
0
0
19
208
0.91
0.11
1.2
1.2
138.30
152.32
u/ml
—
6
84
19
173
1.11
0.10
1.5
1.5
—
—
—
0
0
19
174
1.10
0.09
8.7
9.9
—
—
—
0
0
5
47
1.07
0.09
1.0
1.1
—
—
—
0
0
65
673
0.95
0.09
2.0
2.2
—
—
—
0
0
158
1604
0.96
0.09
3.2
3.3
36.73
38.97
u/l
0.18
153
1551
12
134
0.89
0.09
7.3
9.5
23.88
24.99
mmol/l
0.49
12
134
43
450
0.95
0.09
3.6
4.2
—
—
—
0
0
6
56
1.07
0.08
4.5
3.3
58.83
58.19
%
—
6
56
19
175
1.09
0.08
10.8
8.5
12.23
13.19
kpa
0.37
19
168
19
175
1.09
0.08
10.6
8.5
4.83
5.20
kpa
1.01
19
167
5
65
0.76
0.08
1.0
1.3
—
—
—
0
0
11
123
0.89
0.08
1.8
1.9
—
—
—
0
0
7
67
1.05
0.08
1.4
1.5
—
—
—
0
0
11
98
1.13
0.08
5.0
3.6
0.59
0.60
%
0.06
11
98
19
176
1.09
0.07
1.5
1.5
—
—
—
0
0
19
176
1.09
0.07
1.5
1.5
—
—
—
0
0
19
176
1.09
0.07
1.5
1.5
—
—
—
0
0
53
549
0.96
0.07
2.8
3.3
49.92
62.13
mg/l
0.18
31
357
7
83
0.84
0.07
1.1
1.1
—
—
—
0
0
12
129
0.93
0.03
1.3
1.6
101.99
57.32
ug/l
—
7
108
54
551
0.97
0.03
2.9
3.9
6.34
10.04
mg/mmol
0.52
31
352
13
138
0.94
0.02
1.5
1.6
—
—
—
0
0
19
198
0.96
0.02
4.3
6.2
7.38
7.39
ph
0.19
13
118
78
789
0.98
0.02
8.4
8.1
1.13
1.11
inr
0.23
66
639
67
662
1.02
0.01
2.6
3.4
8.23
8.19
mmol/l
0.03
60
583
75
742
1.02
0.01
1.7
1.6
—
—
—
0
0
12
126
0.95
0.00
1.3
1.5
—
—
—
0
0
196
1966
0.99
0.00
14.4
15.4
13.30
13.33
%
0.14
196
1954
10
98
1.02
0.00
1.3
1.5
—
—
—
0
0
10
101
0.99
0.00
1.4
1.7
—
—
—
0
0
10
97
1.03
0.00
1.3
1.5
1.85
1.35
mm
—
5
69
10
103
0.97
0.00
2.9
4.6
—
—
—
0
0
16
163
0.98
0.00
1.4
1.6
—
—
—
0
0
12
125
0.96
0.00
1.3
1.3
152.29
272.60
miu/ml
—
7
62
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
9.5
—
3.15
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
12.66
—
0
5
0
5
0.00
-0.00
0.0
3.6
—
11.40
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
-0.00
1.6
2.5
0.85
1.38
g/l
—
7
66
5
59
0.84
-0.00
1.6
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
37.80
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
138.85
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
0.03
—
0
7
5
59
0.84
-0.00
1.6
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
44.20
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.4
4.5
15.58
25.55
mg/l
—
5
44
0
5
0.00
-0.00
0.0
5.6
—
9.54
—
0
5
0
5
0.00
-0.00
0.0
2.2
—
13.90
—
0
5
10
100
1.00
-0.00
5.4
3.6
1.02
1.30
%
—
10
100
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
158.57
—
0
7
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
-0.00
3.0
1.8
0.45
2.01
ug/l
—
6
60
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint K11_MANDIBULAR_HYPOPL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_MANDIBULAR_HYPOPL.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: K11_MANDIBULAR_HYPOPL – Mandibular hypoplasia

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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