No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
1049 |
4. Check minimum number of eventsNone |
1049 |
5. Include endpointsNone |
1049 |
6. Filter based on genotype QC (FinnGen only) |
1049 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF10
Major anomalies of jaw size
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13353 | 6803 | 6524 |
| Only index persons | 12168 | 6223 | 5945 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.19 | 0.18 |
| Only index persons | 0.23 | 0.23 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 16.68 | 17.52 | 15.76 |
| Only index persons | 17.56 | 18.45 | 16.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1049 | 621 | 428 |
| Unadjusted period prevalence (%) | 0.20 | 0.21 | 0.19 |
| Median age at first event (years) | 27.42 | 30.00 | 23.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 951
- Matched controls
- 9511
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K07.04
ICD-10 Finland
Macrognathism (mandibular)(maxillary)
+∞
229.8
211
*
5240A
ICD-9 Finland
Dentofacial anomalies, including malocclusion, Major anomalies of jaw size
+∞
166.7
155
*
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
62.4
150.0
174
34
K07.13
ICD-10 Finland
Retrognaty, mandibular
29.8
139.1
190
79
52430
ICD-8 Finland
Dento-facial anomalies including malocclusion, Anomalies of tooth position
+∞
134.7
126
*
SBB10
NOMESCO Finland
Teeth copy
8.6
127.6
313
512
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
+∞
118.2
111
*
K07.01
ICD-10 Finland
Hyperplasia, hypoplasia mandibular
+∞
115.0
108
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
11.4
103.0
205
223
SJD00
NOMESCO Finland
Removal or reattacment of arrow in fixed orthodontisk device
12.4
102.1
194
192
SJX10
NOMESCO Finland
Short check-up visit for orthodontisk therapy
9.3
101.8
229
312
4344
FHL
Osteotomy and shaping of the lower jaw (jaw deformities)
530.2
98.3
96
*
SJD20
NOMESCO Finland
Attachment of modifiable arrow of fixed orthodontisk device
14.0
97.2
174
150
EEC05
NOMESCO Finland
Le Fort I osteotomy
134.8
91.9
97
8
SJD10
NOMESCO Finland
Attachment of arrow to fixed orthodontisk device
10.6
86.9
179
204
EB1MA
NOMESCO Finland
Cephalometry with X-ray
9.9
80.8
172
207
SJC50
NOMESCO Finland
Removal of orthodontisk device with at least 7 brackets
10.9
80.6
162
175
K07.0
ICD-10 Finland
Major anomalies of jaw size
+∞
79.3
75
*
SAA04
NOMESCO Finland
Special inverstigation of mouth
7.3
78.1
206
349
K07.14
ICD-10 Finland
Retrognaty, maxillary
93.3
77.4
85
10
SJC10
NOMESCO Finland
Orthodontic bandage in one tooth
11.4
76.1
149
152
K07.00
ICD-10 Finland
Macrognatia (hyperplasia) of the upper jaw
+∞
71.8
68
*
K07.09
ICD-10 Finland
Anomaly in the size of the jaws UNS
+∞
69.6
66
*
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
72.7
65.3
74
11
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
58.8
64.9
76
14
SJB00
NOMESCO Finland
Fitting of loose orthodontic device with user information
8.6
64.6
149
202
SJD30
NOMESCO Finland
Demanding attachment of arrow to fixed orthodontisk device
12.4
62.9
117
106
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
8.4
62.4
146
202
K07.10
ICD-10 Finland
Asymmetry of jaw
58.0
55.5
65
12
SJD40
NOMESCO Finland
Fixation of ready made palatinal or lingual arrow
8.0
54.6
131
187
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
11.7
53.4
102
97
K07.24
ICD-10 Finland
Open bite
16.0
53.3
88
60
4343
FHL
Lower jaw open osteotomy
+∞
52.6
50
*
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
42.8
51.7
64
16
4347
FHL
Osteotomy of the upper jaw
524.8
50.9
50
*
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
97.2
50.4
55
6
SJB60
NOMESCO Finland
External device grinding and adaptation
8.5
48.8
111
145
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
9.2
47.2
102
122
K07.60
ICD-10 Finland
Snapping jaw
6.3
46.6
132
237
K07.23
ICD-10 Finland
Deep bite
7.1
46.1
119
188
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
8.2
42.1
98
132
52400
ICD-8 Finland
Dento-facial anomalies including malocclusion, Major anomalies of jaw size
+∞
42.0
40
*
SJC00
NOMESCO Finland
Bracket with fixed attachment
57.3
41.8
49
9
SJX20
NOMESCO Finland
Check-up visit for orthodontisk therapy
7.1
41.6
106
164
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
4.8
40.5
145
341
K07.08
ICD-10 Finland
Other specified anomaly in the size of the cores
+∞
38.8
37
*
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
3.7
38.4
187
586
SAA03
NOMESCO Finland
Extended examination of mouth
2.4
35.8
497
2987
SJA01
NOMESCO Finland
Estimation of need for orthodontic care
36.3
35.3
45
13
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
6.4
34.8
95
161
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
5.9
33.6
98
181
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
4.3
33.5
135
355
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
8.1
32.9
76
101
SJD50
NOMESCO Finland
Production and attachment of palatinal or lingual arrow
17.1
32.8
52
32
SJA03
NOMESCO Finland
Demanding plan for orthodontic care
54.9
31.5
37
7
EDC30
NOMESCO Finland
Genioplasty
+∞
31.4
30
*
EBB10
NOMESCO Finland
Insertion of dental implant
12.3
30.7
56
48
SJC40
NOMESCO Finland
Removal of orthodontisk device with at most 6 brackets
5.9
30.7
89
163
SJA04
NOMESCO Finland
Very demanding plan for orthodontic care
68.2
29.1
33
5
4305
FHL
Tooth extraction by cutting
31.1
27.4
36
12
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
5.4
27.4
85
169
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.2
26.4
380
2220
EBB15
NOMESCO Finland
Insertion of dental implant abutment
21.9
26.2
38
18
SXC05
NOMESCO Finland
Other oral or dental procedure
3.6
26.2
128
395
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
4.5
25.2
94
228
5241A
ICD-9 Finland
Dentofacial anomalies, including malocclusion, Anomalies of relationship of jaw to cranial base
89.1
23.8
26
*
SJA02
NOMESCO Finland
Plan for orthodontic care
123.0
22.7
24
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
22.5
439
2855
K00.00
ICD-10 Finland
Hypodontia
9.8
22.2
45
48
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
3.9
21.9
95
265
K07.20
ICD-10 Finland
Crossbite (anterior)(posterior)
6.9
21.8
55
84
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
15.1
21.3
35
24
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
4.3
21.0
81
203
K07.05
ICD-10 Finland
Micrognatia (hypoplasia) of both jaws
+∞
20.9
20
*
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
78.6
20.8
23
*
K07.4
ICD-10 Finland
Malocclusion, unspecified
7.5
20.2
48
67
SPC20
NOMESCO Finland
Attachment of crone of tooth to implant
14.2
19.6
33
24
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.1
19.4
115
408
SJX00
NOMESCO Finland
Reparation of orthodontiskt device by dentist
11.7
18.6
34
30
SXC03
NOMESCO Finland
Other oral or dental procedure
11.7
18.1
33
29
K07.69
ICD-10 Finland
Dislocation of the jaw joint UNS
7.9
18.0
41
54
ZXA10
NOMESCO Finland
Bilateral
2.4
17.5
172
815
52410
ICD-8 Finland
Dento-facial anomalies including malocclusion, Anomalies of jaw-cranial base relationships
+∞
16.7
16
*
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
12.7
14.9
26
21
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
4.7
14.8
50
110
SJB10
NOMESCO Finland
Fitting of loose orthodontic device with user information, demanding
5.5
14.7
43
81
9165
FHL
Removal of osteosynthesis material
6.4
14.2
37
60
SHA04
NOMESCO Finland
Correction of physiology of bite - very demanding therapy visit
7.0
14.0
34
50
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
7.7
14.0
32
43
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
12.9
13.9
24
19
K07.27
ICD-10 Finland
Anomalies of dental arch relationship
8.0
13.9
31
40
52411
ICD-8 Finland
NA
+∞
13.6
13
*
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
9.2
13.3
27
30
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
6.6
12.4
31
48
EB1BD
NOMESCO Finland
Extensive cone beam CT of teeth and jaws (two quarters)
47.3
11.9
14
*
EB1WA
NOMESCO Finland
NA
12.7
11.7
20
16
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
3.7
11.6
51
145
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
13.8
11.5
19
14
K07.21
ICD-10 Finland
Anomalies of dental arch relationship
15.3
11.3
18
12
SPA20
NOMESCO Finland
Selection and insertion of implantdistans
20.3
11.2
16
8
K07.12
ICD-10 Finland
Prognathism (mandibular)(maxillary)
43.8
10.9
13
*
EBA10
NOMESCO Finland
Surgical removal of tooth
2.1
10.8
134
701
EEC02
NOMESCO Finland
Rapid expansion of maxilla
60.7
10.6
12
*
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
3.3
10.5
52
164
SAA01
NOMESCO Finland
Simple examination of mouth
1.6
10.3
684
5821
M01AE03
ATC
ketoprofen; systemic, rectal
1.6
10.2
314
2203
K07
ICD-10 Finland
Dentofacial anomalies [including malocclusion]
9.3
10.0
20
22
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
3.4
10.0
48
148
R06.5
ICD-10 Finland
Mouth breathing
2.3
9.9
90
409
K07.22
ICD-10 Finland
Anomalies of dental arch relationship
5.9
9.7
26
45
EG1DG
NOMESCO Finland
Very extensive MRI examination of mandipular joint with high intensity magnet
55.6
9.7
11
*
4839
FHL
Other measure in this category
55.6
9.7
11
*
EMAK
NOMESCO Finland
NA
3.3
9.6
47
147
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
11.5
9.6
17
15
P01AB01
ATC
metronidazole; oral, rectal
1.6
9.5
342
2491
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
2.0
9.4
118
616
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
3.7
9.0
38
106
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
4.4
9.0
31
72
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
7.0
8.6
20
29
Z47.0
ICD-10 Finland
Follow-up care involving removal of fracture plate and other internal fixation device
9.1
8.6
17
19
K07.29
ICD-10 Finland
Anomaly in the relationship between the tooth arches UNS
90.8
8.4
9
*
EDC45
NOMESCO Finland
Reconstruction of mandible using bone graft
+∞
8.3
8
*
EG1AA
NOMESCO Finland
Mandibular joint X-ray examination
11.8
8.1
14
12
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
10.1
8.0
15
15
K07.62
ICD-10 Finland
Habitual dislocation of the jaw joint
6.4
7.7
19
30
G44.2
ICD-10 Finland
Tension-type headache
1.9
7.6
121
689
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
7.6
261
1861
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
7.2
7.5
17
24
EEC45
NOMESCO Finland
Reconstruction of maxilla using bone graft
80.7
7.4
8
*
K07.02
ICD-10 Finland
Micrognatia (hypoplasia) of both jaws
+∞
7.3
7
*
4359
FHL
Other measure in this category
+∞
7.3
7
*
SJB30
NOMESCO Finland
Extraoral device arrangement and user information
5.2
7.3
21
41
K01.0
ICD-10 Finland
Embedded teeth
3.6
7.2
31
89
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
7.1
631
5463
SJE90
NOMESCO Finland
Finishing face of orthodontick therapy
7.6
6.9
15
20
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
6.9
226
1587
ZXA00
NOMESCO Finland
Right side
1.6
6.9
196
1329
G47.3
ICD-10 Finland
Sleep apnoea
1.6
6.8
180
1198
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.1
6.8
76
381
K07.9
ICD-10 Finland
Dentofacial anomaly, unspecified
16.8
6.8
10
6
SDA02
NOMESCO Finland
Parodonthologic therapy
1.5
6.7
297
2230
EGC30
NOMESCO Finland
Prosthetic replacement of mandibular joint
22.7
6.7
9
*
P01BA02
ATC
hydroxychloroquine; oral
2.1
6.7
75
376
J34.2
ICD-10 Finland
Deviated nasal septum
2.3
6.6
56
249
J01CE02
ATC
phenoxymethylpenicillin; oral
1.4
6.5
631
5502
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
6.5
443
3616
R4110
NOMESCO Finland
Physiotherapy
1.6
6.4
208
1454
EFB50
NOMESCO Finland
Orthodontic procedure connected with ortognathic surgery
70.3
6.4
7
*
SPF00
NOMESCO Finland
Repatation of teeth prosthesis
4.1
6.4
23
57
S63.6
ICD-10 Finland
Sprain and strain of finger(s)
2.6
6.4
43
170
EG1CG
NOMESCO Finland
Extensive MRI examination of mandipular joint with high intensity magnet
11.1
6.3
11
10
DLD00
NOMESCO Finland
Reconstruction of cartilage of nose
18.2
6.3
9
5
52499
ICD-8 Finland
Dento-facial anomalies including malocclusion, Other and unspecified
+∞
6.3
6
*
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.5
6.2
303
2310
Z96.5
ICD-10 Finland
Presence of tooth-root and mandibular implants
10.1
6.0
11
11
K07.35
ICD-10 Finland
Impacted or embedded teeth with abnormal position of such teeth or adjacent teeth
5.2
6.0
17
33
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
531
4052
1.63
13.31
3.8
3.1
0.00
0.00
estimate
0.00
106
742
526
4104
1.56
11.31
3.9
3.1
0.00
0.01
estimate
0.80
105
733
520
4068
1.55
10.91
5.4
4.2
0.01
0.00
estimate
0.40
112
772
304
2133
1.60
10.10
4.0
3.3
0.01
0.01
estimate
0.00
106
750
769
6630
1.60
10.01
4.6
3.9
14.47
14.52
pmol/l
0.26
714
6110
416
3177
1.51
9.29
4.1
3.1
—
—
—
0
0
724
6270
1.50
8.21
8.2
7.3
74.21
79.62
u/l
4.02
685
5922
353
2739
1.44
6.75
3.0
3.0
74.02
38.84
ng/l
0.51
210
1642
582
4937
1.40
6.63
9.9
9.3
3.89
3.94
e9/l
0.23
509
4330
423
3407
1.40
6.49
2.4
2.3
75.18
74.28
nmol/l
0.28
394
3127
705
6202
1.42
6.38
4.7
3.9
9.18
10.17
mm/h
1.67
659
5795
276
2067
1.45
6.31
3.5
2.9
0.39
0.37
e6/l
0.05
219
1536
467
3845
1.39
6.21
3.3
2.7
108.57
105.37
ug/l
0.12
447
3594
604
5201
1.38
6.04
4.4
3.7
11.73
843.11
e6/l
0.95
11
70
295
2258
1.43
5.95
3.4
3.1
18.49
81.12
e6/l
1.42
237
1724
446
3684
1.37
5.65
6.0
7.0
1.21
1.21
mmol/l
0.14
380
3141
391
3165
1.38
5.62
5.0
5.1
36.73
36.56
g/l
0.25
370
2970
213
1551
1.47
5.57
2.7
2.5
5.39
6.53
e6/l
0.58
185
1358
252
1904
1.43
5.40
2.0
1.9
1.07
1.07
mg/l
0.01
189
1423
125
819
1.60
5.31
2.5
2.2
376.04
368.23
nmol/l
0.17
114
761
49
242
2.08
5.28
1.3
1.2
—
—
—
0
0
273
2109
1.40
5.12
1.6
1.6
—
—
—
0
0
856
7912
1.45
5.02
5.2
4.5
1.79
1.97
mu/l
0.66
800
7379
929
8732
1.56
4.98
14.6
11.7
20.29
21.83
mg/l
0.72
728
6702
829
7622
1.42
4.98
16.8
14.3
13.47
13.50
%
0.18
820
7470
48
242
2.03
4.91
1.3
1.2
—
—
—
0
0
243
1852
1.41
4.91
2.5
2.1
2.74
2.90
mg/l
0.55
212
1594
53
278
1.95
4.86
1.7
1.6
0.13
0.05
iu/ml
—
7
38
348
2816
1.35
4.86
1.9
1.8
99.72
96.78
pmol/l
0.49
189
1484
130
885
1.54
4.68
5.8
5.7
—
—
—
0
0
50
899
0.53
4.61
3.9
3.9
31.26
31.32
%
0.01
38
631
113
749
1.57
4.58
4.3
4.7
249.69
241.15
u/l
0.24
106
719
280
2209
1.36
4.56
2.0
2.1
201.40
219.40
u/l
0.17
265
2091
481
4109
1.32
4.54
6.5
6.5
10.86
11.24
umol/l
0.44
460
3902
205
1540
1.41
4.47
1.3
1.3
20.90
29.51
iu/ml
1.24
70
488
263
2064
1.37
4.41
4.5
4.1
92.43
93.80
%
0.42
255
2012
68
412
1.70
3.96
1.9
1.6
344.36
297.08
mu/l
0.40
61
372
233
1823
1.36
3.94
4.3
3.2
1.02
1.02
kg/l
0.06
30
230
194
1475
1.39
3.92
2.1
2.1
—
—
—
0
0
525
4608
1.28
3.79
4.7
4.8
6.45
6.55
mmol/l
0.63
495
4276
248
1972
1.34
3.76
1.4
1.4
2.13
2.29
g/l
0.79
157
1240
165
1234
1.40
3.67
3.4
2.6
1.07
0.95
e6/l
0.17
100
688
86
566
1.57
3.63
2.8
3.6
1.23
1.23
mmol/l
0.19
75
493
475
4133
1.27
3.62
7.6
6.1
55.93
55.99
%
0.04
447
3906
307
2532
1.30
3.56
2.7
2.6
56.16
55.98
u/l
0.01
287
2368
918
8722
1.42
3.48
14.6
12.7
139.74
139.70
mmol/l
0.22
905
8515
479
4191
1.26
3.43
8.0
6.3
29.51
29.47
%
0.03
452
3948
84
558
1.55
3.42
1.4
1.3
—
—
—
0
0
920
8751
1.42
3.41
14.6
12.8
3.94
3.94
mmol/l
0.31
905
8522
30
148
2.06
3.33
1.5
1.5
—
—
—
0
0
16
59
2.74
3.33
1.3
1.2
1.05
1.05
ratio
—
6
26
70
452
1.59
3.23
2.7
2.3
3460.04
3636.58
u/l
0.03
28
186
41
229
1.82
3.20
1.2
1.1
0.73
1.73
u/ml
0.82
16
101
16
62
2.61
3.05
2.2
1.4
—
—
—
0
0
384
3309
1.25
3.04
5.8
6.4
1.21
1.22
mmol/l
0.47
352
3046
73
487
1.54
2.94
1.9
1.6
—
—
—
0
0
158
1217
1.35
2.94
3.2
2.8
2.43
2.43
mmol/l
0.16
143
1075
38
214
1.80
2.91
1.0
1.1
8.65
8.46
u/ml
0.02
23
121
38
215
1.80
2.87
2.0
1.7
—
—
—
0
0
34
186
1.86
2.86
4.6
4.1
54.06
55.54
%
0.30
34
186
139
1054
1.37
2.86
2.2
2.5
2.43
2.41
g/l
0.25
128
978
38
216
1.79
2.83
4.5
4.1
1.40
1.37
mmol/l
0.08
38
210
17
72
2.38
2.73
1.8
2.7
16.27
11.84
%
0.50
11
43
300
2541
1.25
2.71
3.0
3.3
2.36
2.36
mmol/l
0.28
274
2291
54
344
1.60
2.67
1.4
1.4
—
—
—
0
0
81
569
1.46
2.58
3.1
3.3
4.40
4.65
pmol/l
1.58
73
503
155
1217
1.32
2.54
2.7
2.5
104.61
108.78
ug/g
0.08
127
969
53
342
1.58
2.50
1.7
1.6
11.84
9.07
u/l
0.59
37
279
339
2937
1.23
2.46
3.4
3.4
32.08
31.86
u/l
0.05
325
2802
146
1143
1.32
2.44
2.3
2.5
16.02
14.14
umol/l
1.98
137
1068
192
1560
1.28
2.44
1.6
1.5
20.60
20.74
nmol/l
0.05
174
1367
96
704
1.40
2.43
2.7
2.2
12.73
13.04
nmol/l
0.14
82
640
205
1681
1.27
2.42
3.0
3.0
527.35
755.46
ng/l
1.32
169
1387
52
338
1.57
2.39
3.2
3.1
90.33
92.73
%
0.31
46
321
37
221
1.70
2.37
1.4
1.5
301.35
305.06
ug/g
0.04
24
127
168
1347
1.29
2.37
2.2
2.0
—
—
—
0
0
40
245
1.66
2.34
1.5
2.2
1.25
1.42
g/l
0.45
35
214
854
8137
1.27
2.32
4.2
3.9
5.77
5.83
mmol/l
0.67
804
7576
182
1479
1.28
2.31
1.3
1.2
7.42
10.61
u/ml
0.36
87
598
33
194
1.72
2.25
2.0
1.4
—
—
—
0
0
139
1098
1.31
2.19
1.7
1.6
1278.94
1189.82
nmol/l
0.53
109
841
178
1452
1.27
2.19
1.8
1.6
454.12
41360428.82
pmol/l
1.90
155
1250
30
174
1.75
2.15
2.9
2.4
67.75
108.82
ug/min
0.35
16
109
958
9288
1.36
2.12
11.4
9.5
28.25
27.97
u/l
0.17
927
9027
15
68
2.22
2.11
1.9
2.7
—
—
—
0
0
124
971
1.31
2.09
2.3
2.5
26.91
24.30
%
1.13
110
846
66
466
1.44
2.09
2.8
2.9
110.41
127.07
ng/l
0.29
58
424
33
199
1.68
2.07
1.3
1.2
57.36
58.58
u/ml
—
5
17
259
2219
1.22
2.06
1.4
1.3
1.03
1.57
u/ml
0.85
69
582
49
327
1.52
2.04
2.0
1.7
—
—
—
0
0
91
688
1.35
1.96
1.8
1.9
—
—
—
0
0
11
45
2.46
1.93
1.2
1.1
204.36
550.67
u/l
0.75
11
39
28
165
1.72
1.92
1.2
1.0
4.31
4.40
u/ml
0.01
16
60
152
1242
1.26
1.86
4.4
4.2
0.84
0.81
mmol/l
3.18
138
1181
6
17
3.54
1.84
2.3
1.5
—
—
—
0
0
95
733
1.33
1.80
8.1
9.1
1.88
1.02
mmol/l
1.08
73
593
877
8452
1.23
1.71
15.1
12.4
40.04
40.62
%
1.15
668
6732
11
48
2.31
1.71
3.5
1.9
—
—
—
0
0
237
2049
1.20
1.70
2.4
2.6
5570.61
3816.94
umol/l
0.24
222
1833
702
6639
1.17
1.67
3.4
3.3
—
—
—
0
0
16
290
0.54
1.65
2.4
1.9
—
—
—
0
0
23
136
1.71
1.59
1.4
1.4
—
—
—
0
0
23
136
1.71
1.59
1.4
1.4
—
—
—
0
0
1011
9940
1.47
1.56
20.9
17.1
256.14
256.14
e9/l
0.00
1003
9707
33
216
1.54
1.55
2.2
2.9
—
—
—
0
0
26
161
1.63
1.53
1.1
1.2
7.80
5.48
u/ml
—
10
65
24
146
1.66
1.51
1.6
1.8
—
—
—
0
0
24
146
1.66
1.51
1.1
1.1
5.55
7.33
u/ml
0.17
13
55
97
775
1.28
1.46
1.6
1.8
—
—
—
0
0
104
839
1.27
1.45
2.0
2.0
—
—
—
0
0
1011
9950
1.44
1.43
20.9
17.1
4.58
4.58
e12/l
0.03
1001
9697
35
238
1.49
1.41
2.1
1.7
—
—
—
0
0
22
134
1.66
1.40
1.0
1.0
0.03
0.58
u/ml
—
6
33
1011
9954
1.43
1.38
20.9
17.2
6.52
6.62
e9/l
0.85
1002
9698
89
709
1.28
1.38
1.3
1.2
121.93
145.63
iu/ml
0.23
38
283
6
23
2.62
1.37
1.7
1.1
—
—
—
0
0
5
17
2.95
1.36
1.0
1.9
—
—
—
0
0
97
786
1.26
1.32
1.6
1.8
—
—
—
0
0
881
8546
1.19
1.31
4.7
4.4
2.89
2.87
mmol/l
0.21
834
8039
647
6139
1.14
1.29
3.3
3.2
49.52
47.23
u/l
0.28
613
5851
416
3838
1.14
1.27
4.0
3.9
—
—
—
0
0
22
138
1.61
1.27
1.4
1.6
—
—
—
0
0
787
7573
1.16
1.26
5.3
4.9
38.89
38.94
mmol/mol
0.03
744
7145
8
36
2.23
1.24
1.5
2.3
—
—
—
0
0
8
36
2.23
1.24
1.5
2.3
—
—
—
0
0
871
8451
1.18
1.24
4.4
4.0
4.78
4.77
mmol/l
0.18
828
7992
18
289
0.62
1.23
1.2
1.4
—
—
—
0
0
18
289
0.62
1.23
1.2
1.4
—
—
—
0
0
18
289
0.62
1.23
1.2
1.4
—
—
—
0
0
30
204
1.48
1.23
1.2
1.1
0.74
4.26
u/ml
—
8
44
43
314
1.39
1.22
1.5
1.7
—
—
—
0
0
18
288
0.62
1.22
1.2
1.4
—
—
—
0
0
840
8131
1.17
1.21
4.1
3.6
1.31
1.31
mmol/l
0.06
790
7645
17
101
1.69
1.20
1.5
1.3
—
—
—
0
0
67
526
1.29
1.19
1.5
1.5
19.68
26.81
iu/l
1.06
53
438
25
165
1.53
1.18
1.1
1.2
2.10
4.04
u/ml
—
10
53
92
754
1.24
1.16
2.5
2.6
37.05
103.35
u/l
0.53
83
646
116
975
1.21
1.15
2.4
3.2
8.61
7.61
umol/l
0.16
99
844
14
80
1.76
1.13
4.4
2.5
3.97
3.99
mmol/l
0.05
14
80
14
80
1.76
1.13
4.4
2.5
106.64
105.72
mmol/l
0.35
14
80
17
269
0.63
1.12
2.2
1.7
—
—
—
0
0
136
1165
1.19
1.11
3.7
2.8
4.77
2.50
e6/l
0.76
75
622
13
74
1.77
1.07
1.0
1.1
—
—
—
0
0
13
74
1.77
1.07
1.0
1.1
—
—
—
0
0
827
8020
1.15
1.05
12.7
10.3
88.87
88.62
ml/min/173m2
0.13
686
6472
13
75
1.74
1.03
1.0
1.1
—
—
—
0
0
13
75
1.74
1.03
1.0
1.1
—
—
—
0
0
13
75
1.74
1.03
1.0
1.1
—
—
—
0
0
53
413
1.30
1.02
4.2
3.9
132.08
129.96
g/l
0.30
53
405
12
68
1.77
1.00
4.0
3.7
—
—
—
0
0
25
173
1.46
0.98
1.5
1.4
31.19
23.88
u/l
0.43
19
145
0
32
0.00
0.95
0.0
2.2
—
—
—
0
0
864
8421
1.15
0.95
4.3
4.0
1.46
1.46
mmol/l
0.15
819
7929
23
158
1.47
0.94
1.2
1.1
—
—
—
0
0
18
117
1.55
0.94
3.2
2.6
20.05
22.51
nmol/l
0.54
18
111
76
627
1.23
0.93
1.6
2.4
76.25
74.05
ml/min/173m2
0.13
28
248
40
305
1.32
0.91
1.4
1.5
—
—
—
0
0
11
63
1.75
0.90
1.2
1.2
—
—
—
0
0
5
101
0.49
0.89
1.8
1.5
—
—
—
0
0
5
101
0.49
0.89
1.8
1.5
—
—
—
0
0
8
42
1.91
0.88
1.0
1.2
11.75
11.09
u/l
—
8
35
8
43
1.87
0.87
1.0
1.2
64.63
66.59
u/l
—
8
37
83
697
1.21
0.87
4.9
5.4
2.51
1.90
mmol/l
0.93
74
562
36
273
1.33
0.86
1.1
1.1
—
—
—
0
0
8
46
1.74
0.82
10.1
3.0
547.75
654.13
u/ml
—
8
46
23
163
1.42
0.82
1.1
1.1
—
—
—
0
0
156
1392
1.14
0.79
3.6
3.4
451.54
479.73
ng/l
0.04
119
956
62
511
1.23
0.79
1.9
2.8
66.29
67.29
g/l
0.51
55
479
23
315
0.72
0.78
1.2
1.4
—
—
—
0
0
5
100
0.50
0.77
1.8
1.5
—
—
—
0
0
10
59
1.70
0.76
1.0
1.0
—
—
—
0
0
12
75
1.61
0.75
1.2
1.4
108.20
58.66
pmol/l
—
5
22
17
116
1.47
0.74
1.0
1.1
—
—
—
0
0
91
1051
0.85
0.74
1.8
1.7
—
—
—
0
0
19
133
1.44
0.74
1.3
1.4
6.95
7.55
mmol/l
0.39
11
93
36
281
1.29
0.73
1.3
1.3
—
—
—
0
0
10
61
1.65
0.68
1.3
1.4
—
—
—
0
0
27
206
1.32
0.66
1.3
1.9
149.91
1014.65
e6/l
0.76
22
167
27
206
1.32
0.66
1.3
1.9
4.00
6.51
e6/l
0.43
22
162
7
44
1.59
0.65
1.7
1.6
—
1224630.00
—
0
5
84
730
1.16
0.64
2.5
3.0
—
—
—
0
0
6
101
0.59
0.62
1.7
1.5
—
—
—
0
0
6
102
0.59
0.62
1.7
1.5
—
—
—
0
0
6
102
0.59
0.62
1.7
1.5
—
—
—
0
0
234
2174
1.10
0.61
4.1
3.8
1.85
1.86
ug/l
0.01
213
1986
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
18
131
1.38
0.59
1.1
1.3
—
—
—
0
0
14
97
1.45
0.59
1.1
1.9
—
—
—
0
0
15
106
1.42
0.58
1.1
1.3
—
—
—
0
0
8
54
1.49
0.57
1.3
1.8
—
—
—
0
0
85
748
1.15
0.56
2.4
2.7
0.22
0.23
g/l
0.19
80
707
6
36
1.67
0.56
1.8
2.6
—
—
—
0
0
11
73
1.51
0.56
1.4
1.5
1.78
1.50
nmol/l
0.38
11
67
13
91
1.43
0.53
9.9
6.1
11.36
10.52
mg/l
0.44
13
83
6
39
1.54
0.53
1.0
1.0
—
—
—
0
0
13
181
0.71
0.53
1.5
1.4
—
—
—
0
0
149
1367
1.10
0.51
2.2
1.8
1.41
1.42
%
0.08
127
1226
6
40
1.50
0.51
1.0
1.1
2154.83
1712.60
miu/ml
—
6
40
18
135
1.34
0.51
1.4
1.1
—
—
—
0
0
9
65
1.39
0.50
1.2
1.1
—
—
—
0
0
20
153
1.31
0.50
2.4
3.3
19.90
26.16
mg/l
0.37
12
93
33
270
1.23
0.50
1.5
1.6
—
—
—
0
0
21
162
1.30
0.50
2.5
2.0
142.13
133.68
g/l
0.55
15
129
6
41
1.47
0.50
1.2
1.1
—
—
—
0
0
10
67
1.50
0.49
1.5
1.8
—
—
—
0
0
29
236
1.24
0.47
1.3
1.2
5.48
13.16
u/ml
—
5
35
48
412
1.17
0.46
1.7
1.7
4.81
3.57
mg/l
0.26
34
277
17
129
1.32
0.46
5.2
4.1
157.32
267.95
u/ml
0.20
17
121
22
174
1.27
0.45
1.5
1.2
—
—
—
0
0
5
31
1.62
0.43
1.0
1.4
—
—
—
0
0
28
230
1.22
0.43
1.3
1.8
376.04
450.11
mg/l
1.47
28
215
0
15
0.00
0.41
0.0
2.9
—
0.53
—
0
15
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.47
0.40
1.2
1.2
0.31
0.29
g/l
—
5
28
5
35
1.43
0.39
1.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.8
—
2.04
—
0
8
162
1516
1.08
0.39
1.6
1.4
—
—
—
0
0
21
169
1.25
0.39
1.2
1.3
—
—
—
0
0
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
5
36
1.39
0.38
1.0
1.2
86.80
109.93
%
—
5
30
28
234
1.20
0.37
1.5
2.0
—
—
—
0
0
6
42
1.43
0.35
1.2
1.1
137.00
249.31
iu/ml
—
6
42
29
246
1.18
0.34
2.0
1.9
2.50
4.68
iu/l
2.50
16
93
14
109
1.29
0.33
1.6
1.7
—
—
—
0
0
6
86
0.70
0.33
6.0
1.6
—
—
—
0
0
202
1920
1.06
0.33
2.1
2.2
—
—
—
0
0
20
164
1.22
0.32
2.8
4.3
—
1819.31
—
0
16
33
285
1.16
0.32
1.2
1.9
—
—
—
0
0
6
47
1.28
0.32
1.5
1.5
4.82
6.18
mmol/l
—
6
47
16
129
1.24
0.30
1.1
1.1
—
—
—
0
0
11
84
1.31
0.30
1.2
1.1
173.27
243.82
mg/l
2.51
11
71
7
57
1.23
0.29
1.7
2.5
—
—
—
0
0
17
205
0.83
0.28
1.4
1.9
—
—
—
0
0
109
1024
1.07
0.26
6.0
6.8
1.05
1.07
mmol/l
0.33
102
966
23
267
0.86
0.26
1.2
1.4
—
—
—
0
0
30
263
1.14
0.26
2.5
3.3
2701.72
974.14
u/ml
0.28
24
225
19
160
1.19
0.25
1.8
2.8
3.18
8.51
umol/l
1.91
12
116
17
142
1.20
0.24
3.4
2.2
17.08
16.93
%
—
9
80
17
142
1.20
0.24
1.8
1.5
—
—
—
0
0
11
87
1.27
0.24
1.3
1.2
36.00
34.51
mg/l
0.05
11
69
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
189
1.17
0.24
8.0
4.0
0.41
0.34
u/ml
—
10
95
5
38
1.32
0.23
1.0
1.3
—
—
—
0
0
24
209
1.15
0.23
1.3
1.5
—
—
—
0
0
5
39
1.28
0.23
1.2
1.2
—
—
—
0
0
7
92
0.76
0.22
1.1
1.3
—
—
—
0
0
5
40
1.25
0.22
1.0
1.3
—
—
—
0
0
119
1130
1.06
0.22
1.7
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
5.2
—
—
—
0
0
0
12
0.00
0.21
0.0
5.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
5
43
1.16
0.21
1.0
1.3
—
20.75
—
0
8
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
5.47
—
0
9
36
327
1.10
0.19
1.2
1.3
—
—
—
0
0
17
146
1.17
0.19
1.5
1.7
—
—
—
0
0
35
384
0.91
0.18
1.3
1.3
143.28
246.29
miu/ml
1.79
18
185
41
378
1.09
0.17
1.8
1.7
—
—
—
0
0
10
82
1.22
0.17
1.0
1.1
—
—
—
0
0
5
69
0.72
0.17
1.0
1.4
—
—
—
0
0
5
70
0.71
0.16
1.2
1.8
—
—
—
0
0
5
70
0.71
0.16
1.2
1.8
—
—
—
0
0
5
70
0.71
0.16
1.2
1.8
—
—
—
0
0
8
70
1.14
0.16
1.1
1.6
0.83
1.00
g/l
—
8
70
21
187
1.13
0.16
1.7
1.5
0.61
0.30
nmol/l
0.69
15
149
10
119
0.84
0.15
1.0
1.1
—
—
—
0
0
13
112
1.16
0.14
4.8
3.7
1.00
1.27
%
0.22
13
94
16
181
0.88
0.14
1.1
1.1
—
8.94
—
0
12
10
84
1.19
0.14
1.3
1.1
—
—
—
0
0
10
84
1.19
0.14
1.2
2.0
—
—
—
0
0
52
551
0.94
0.13
2.9
4.5
75.09
76.42
ng/l
0.04
47
503
63
663
0.95
0.13
4.3
4.4
3.69
17.98
ug/l
1.16
48
528
45
424
1.06
0.12
1.5
1.9
—
—
—
0
0
15
135
1.11
0.09
1.0
1.1
1.50
1.45
g/l
0.20
15
123
17
155
1.10
0.09
1.1
1.1
—
—
—
0
0
21
194
1.08
0.09
1.0
1.2
—
—
—
0
0
236
2398
0.98
0.09
3.4
3.2
8.30
8.28
mmol/l
0.02
207
2068
56
538
1.04
0.08
2.7
4.2
1.83
1.60
mmol/l
0.30
39
390
10
113
0.88
0.08
1.0
1.1
—
—
—
0
0
53
551
0.96
0.08
1.4
1.5
—
—
—
0
0
58
559
1.04
0.08
2.7
4.2
5.25
5.15
kpa
0.33
53
528
7
68
1.03
0.08
1.9
1.8
—
—
—
0
0
12
133
0.90
0.07
2.8
3.4
2.89
33.96
u/ml
0.53
12
126
8
78
1.03
0.07
1.0
1.2
—
—
—
0
0
7
82
0.85
0.07
1.1
1.0
290.29
284.68
mg/l
—
7
72
7
85
0.82
0.07
1.3
1.2
—
—
—
0
0
15
163
0.92
0.07
1.1
1.0
0.78
1.80
u/ml
—
8
77
9
102
0.88
0.06
1.0
1.1
—
—
—
0
0
12
109
1.10
0.06
1.3
1.7
—
—
—
0
0
38
367
1.04
0.04
1.5
1.4
—
—
—
0
0
56
546
1.03
0.04
1.1
1.0
—
—
—
0
0
10
91
1.10
0.04
1.1
1.1
—
—
—
0
0
19
200
0.95
0.03
1.4
1.9
—
—
—
0
0
177
1755
1.01
0.03
3.9
3.4
22.31
21.24
%
0.44
70
705
21
218
0.96
0.02
1.5
1.6
—
—
—
0
0
130
1292
1.01
0.01
2.6
2.5
0.71
0.69
ug/l
0.15
82
745
12
126
0.95
0.00
1.3
1.6
—
—
—
0
0
12
124
0.97
0.00
1.4
1.7
—
—
—
0
0
75
746
1.01
0.00
20.5
16.2
1.51
1.26
inr
—
8
108
10
99
1.01
0.00
1.6
1.9
—
—
—
0
0
221
2209
1.00
0.00
1.6
1.7
1.41
1.43
mmol/l
0.11
183
1911
43
427
1.01
0.00
1.5
1.4
—
—
—
0
0
15
145
1.03
0.00
1.3
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
9.13
—
0
6
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
8
88
0.91
0.00
1.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
6.2
—
—
—
0
0
5
51
0.98
0.00
1.2
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
57
0.88
0.00
1.2
1.1
—
—
—
0
0
7
69
1.01
0.00
1.0
1.2
—
—
—
0
0
5
57
0.88
0.00
4.4
7.4
—
65.95
—
0
19
5
55
0.91
0.00
3.6
3.0
—
—
—
0
0
5
59
0.85
0.00
1.6
1.7
—
—
—
0
0
7
77
0.91
0.00
1.0
1.2
—
—
—
0
0
6
61
0.98
0.00
1.0
1.4
—
—
—
0
0
212
2120
1.00
0.00
3.8
4.0
7.26
8.89
mg/mmol
0.28
127
1356
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
58.86
—
0
7
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_MAJOR_ANOMALI_JAW_SIZE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_MAJOR_ANOMALI_JAW_SIZE | 1.127 [0.86, 1.48] | 0.383 |
| Birth year | 0.992 [0.98, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 4789 females with K11_MAJOR_ANOMALI_JAW_SIZE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_MAJOR_ANOMALI_JAW_SIZE | 0.887 [0.69, 1.14] | 0.353 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 4404 males with K11_MAJOR_ANOMALI_JAW_SIZE died.
Mortality risk
Mortality risk for people of age
years, who have K11_MAJOR_ANOMALI_JAW_SIZE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.115% | 0.146% |
| 5 | 0.521% | 1.032% |
| 10 | 1.407% | 2.595% |
| 15 | 2.921% | 4.935% |
| 20 | 5.07% | 8.565% |
Relationships between endpoints
↥Index endpoint: K11_MAJOR_ANOMALI_JAW_SIZE – Major anomalies of jaw size
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data