No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
902 |
4. Check minimum number of eventsNone |
902 |
5. Include endpointsNone |
902 |
6. Filter based on genotype QC (FinnGen only) |
824 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H49
- Name in latin
- Paresis/paralysis nervi trochlearis
Similar endpoints
↥List of similar endpoints to
Fourth [trochlear] nerve palsy
based on the number of shared cases.
Similar with more cases:
- Paralytic strabismus
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4786 | 2139 | 2632 |
| Only index persons | 4492 | 2022 | 2470 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.06 | 0.07 |
| Only index persons | 0.09 | 0.07 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 57.12 | 55.81 | 58.14 |
| Only index persons | 57.65 | 56.67 | 58.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 824 | 421 | 403 |
| Unadjusted period prevalence (%) | 0.17 | 0.15 | 0.18 |
| Median age at first event (years) | 60.48 | 56.94 | 64.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 851
- Matched controls
- 8510
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H53.2
ICD-10 Finland
Diplopia
61.5
307.7
351
96
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
+∞
307.7
851
*
H50.2
ICD-10 Finland
Vertical strabismus
1842.2
159.6
150
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.0
106.0
228
489
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.1
96.3
196
397
CEC00
NOMESCO Finland
Recession of extraocular muscle
1015.8
94.8
91
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
+∞
65.5
62
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.2
53.8
167
468
AA1AD
NOMESCO Finland
CT of head and brain
2.9
48.1
385
1911
XCK00
NOMESCO Finland
Perimetry
4.7
41.0
103
243
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
39.9
38
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.9
39.3
234
975
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
394.4
38.4
38
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.4
38.0
65
108
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
+∞
30.4
29
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
7.6
29.1
42
58
CE2W4
NOMESCO Finland
Eye movement mapping
103.6
27.8
30
*
H50.52
ICD-10 Finland
Exophoria
31.2
27.4
36
12
CEW99
NOMESCO Finland
Other operation on extraocular muscle
+∞
25.1
24
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
+∞
24.1
23
*
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
+∞
22.0
21
*
T90.5
ICD-10 Finland
Sequelae of intracranial injury
8.1
21.4
29
37
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
4.1
21.3
61
158
CEC20
NOMESCO Finland
Recession and advancement of extraocular muscle
+∞
20.9
20
*
H50.9
ICD-10 Finland
Strabismus, unspecified
204.6
19.6
20
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
7.4
19.2
28
39
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
18.8
18
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
18.3
398
2693
H53.1
ICD-10 Finland
Subjective visual disturbances
2.9
17.4
84
305
TAB00
NOMESCO Finland
Lumbar puncture
3.5
17.1
62
189
S06.3
ICD-10 Finland
Focal brain injury
6.5
15.9
26
41
H50.31
ICD-10 Finland
Intermittent exotropia
162.9
15.5
16
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
15.1
455
3336
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
16.8
14.8
23
14
H50.8
ICD-10 Finland
Other specified strabismus
+∞
14.6
14
*
H50.4
ICD-10 Finland
Other and unspecified heterotropia
+∞
14.6
14
*
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
6.7
14.5
23
35
D32.06
ICD-10 Finland
Benign tumor of the meninges os petrosum or clivus area
152.5
14.5
15
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.9
14.0
69
253
CS494
NOMESCO Finland
Other visual field testing
4.1
13.7
38
96
SPAT1312
SPAT
General health counselling
1.8
13.7
277
1793
G51.0
ICD-10 Finland
Bell palsy
4.4
13.2
33
77
PA7BD
NOMESCO Finland
CT angiography of neck and brain
5.6
13.1
25
46
SPAT1301
SPAT
No procedures
1.8
12.6
284
1889
CEC30
NOMESCO Finland
Resection of extraocular muscle
+∞
12.5
12
*
F95
ICPC
Strabismus
131.9
12.5
13
*
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
9.8
12.3
24
25
S06.2
ICD-10 Finland
Diffuse brain injury
8.8
12.1
25
29
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.6
11.9
69
275
H52.1
ICD-10 Finland
Myopia
5.3
11.6
23
44
SPAT1153
SPAT
Removal of sutures
1.7
11.5
291
1990
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
5.6
11.2
21
38
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
11.2
262
1752
R51.80
ICD-10 Finland
Headache
1.9
10.9
147
830
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
4.2
10.7
28
68
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
10.7
204
1285
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
10.6
334
2407
H50.30
ICD-10 Finland
Intermittent esotropy
+∞
10.4
10
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
4.0
10.4
29
74
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
9.3
10.1
20
22
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.0
9.8
107
560
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
9.8
259
1776
108
Kela drug reimbursment
Myasthenia gravis
20.3
9.8
14
7
SPAT1260
SPAT
Consultation of another employee
1.8
9.7
157
938
SPAT1310
SPAT
Counselling related to known health issue
1.6
9.7
271
1885
G70.0
ICD-10 Finland
Myasthenia gravis
15.2
9.5
15
10
SPAT1263
SPAT
Sampling
1.6
9.3
350
2609
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
5.1
9.1
19
38
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
9.2
9.1
18
20
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
9.1
160
981
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.5
9.0
30
87
N03AX14
ATC
levetiracetam; systemic
3.3
9.0
33
102
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.3
8.7
66
299
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.0
8.5
93
487
H25.0
ICD-10 Finland
Senile incipient cataract
2.3
8.4
64
290
L04AX01
ATC
azathioprine; systemic
2.9
8.4
40
144
H50.59
ICD-10 Finland
Heterophor UNS
+∞
8.3
8
*
3503
FHL
Single muscle retroposition
+∞
8.3
8
*
A98
ICPC
Health maint/preventive medicine
2.9
8.3
820
7675
N07AA02
ATC
pyridostigmine; systemic
10.9
8.3
15
14
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.5
8.2
50
205
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
8.1
299
2203
ZXA10
NOMESCO Finland
Bilateral
1.7
8.1
164
1043
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
8.0
346
2637
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
8.0
75
371
N02BE01
ATC
paracetamol; systemic, rectal
1.9
8.0
756
6876
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
9.5
7.8
15
16
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
7.8
172
1119
UJF32
NOMESCO Finland
Coloscopy
1.6
7.7
226
1576
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
2.8
7.5
38
142
R42
ICD-10 Finland
Dizziness and giddiness
1.6
7.5
206
1415
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.8
7.5
120
714
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.5
7.4
279
2055
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.3
7.4
28
88
XCD00
NOMESCO Finland
Clinical examination of eye in general anaesthesia
80.8
7.4
8
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
7.3
75
384
CEC80
NOMESCO Finland
Partial transposition of extraocular muscle
+∞
7.3
7
*
J01DB01
ATC
cefalexin; oral
1.6
7.2
683
6086
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
20.2
7.1
10
5
JN3AD
NOMESCO Finland
Abdominal CT examination
1.8
7.1
118
708
G35
ICD-10 Finland
Multiple sclerosis
4.3
7.0
18
43
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.3
6.9
50
222
XX3DW
NOMESCO Finland
Time consuming IT work
1.8
6.9
103
598
UKC02
NOMESCO Finland
Cystoscopy
1.7
6.9
142
905
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
2.5
6.9
42
173
N29
ICPC
Neurological sympt/complt other
3.4
6.7
23
68
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
6.7
105
619
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.7
6.7
36
139
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
6.7
158
1044
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
7.9
6.6
14
18
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.6
6.6
164
1096
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.9
6.6
79
428
NF1AA
NOMESCO Finland
Hip X-ray examination
1.9
6.5
88
495
WX140
NOMESCO Finland
Parabulbar anesthesy
2.3
6.5
50
228
XCW11
NOMESCO Finland
Assessment of strabismus
70.4
6.4
7
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.7
6.4
34
131
B01AC04
ATC
clopidogrel; oral
1.6
6.4
153
1014
3785A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Paralytic strabismus
+∞
6.3
6
*
H50.51
ICD-10 Finland
Esophoria
+∞
6.3
6
*
CEC85
NOMESCO Finland
Combined correction of cyclodeviation
+∞
6.3
6
*
H50
ICD-10 Finland
Other strabismus
+∞
6.3
6
*
H50.50
ICD-10 Finland
Alternating hyperphoria
26.9
6.2
8
*
SPAT1216
SPAT
Assessment of functional ability
1.6
6.2
139
904
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.2
6.1
49
229
H02.4
ICD-10 Finland
Ptosis of eyelid
2.7
6.0
32
123
CJB10
NOMESCO Finland
Laser discission of secondary cataract
1.9
6.0
72
390
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
55
47
12.44
54.57
1.2
1.1
1.17
5.32
nmol/l
—
7
9
409
2503
2.22
28.22
2.5
2.2
150.00
231.56
u/l
1.58
390
2381
452
3068
2.01
21.78
4.8
4.1
34.93
67.40
ng/l
0.82
334
2259
358
2307
1.95
19.37
4.8
4.1
0.00
0.01
estimate
0.96
105
807
177
877
2.29
19.35
9.2
7.6
—
—
—
0
0
28
48
6.00
15.80
1.1
1.1
669.10
236.74
mg/l
0.47
20
43
28
50
5.76
15.16
1.2
1.1
110.56
42.69
mg/l
0.45
18
43
24
40
6.15
13.92
1.7
1.2
0.44
0.51
ratio
—
9
23
493
3763
1.74
13.61
14.4
16.1
1.28
1.28
inr
0.02
415
3158
52
168
3.23
13.11
1.9
1.2
21.29
34.42
e6/l
0.23
41
122
52
170
3.19
12.87
1.9
1.3
2535.76
800.75
e6/l
0.31
46
128
615
5061
1.78
12.38
5.8
4.8
479.57
2065.61
e6/l
—
7
89
524
4128
1.70
12.33
4.8
4.0
0.00
0.37
estimate
0.53
104
838
107
520
2.21
11.96
2.5
2.5
28.17
18.33
au/ml
—
6
43
801
7252
2.78
11.88
19.8
17.2
21.91
25.57
mg/l
3.14
665
6035
568
4603
1.70
11.73
6.4
5.2
6.66
6.69
mmol/l
0.17
544
4381
99
472
2.24
11.59
1.3
1.3
42.20
53.34
au/ml
—
5
36
517
4099
1.67
11.49
4.7
4.0
0.00
3.92
estimate
0.80
113
893
23
45
5.23
11.31
1.2
1.0
—
—
—
0
0
466
3625
1.63
10.93
8.1
6.6
1.20
1.21
mmol/l
1.72
434
3362
509
4051
1.64
10.85
4.7
4.0
0.00
0.00
estimate
0.50
109
876
108
550
2.10
10.70
6.2
9.6
1.29
1.28
%
0.00
108
545
406
3090
1.60
10.14
4.6
3.9
0.00
0.02
estimate
2.03
99
743
807
7415
2.71
10.08
24.9
20.6
139.71
139.65
mmol/l
0.31
797
7272
807
7422
2.69
9.92
25.0
20.8
4.00
3.98
mmol/l
0.80
795
7270
161
968
1.82
9.77
7.7
7.7
0.89
1.04
mmol/l
0.17
135
799
21
44
4.87
9.57
1.0
1.0
1.32
1.13
u/l
—
9
26
25
63
4.06
9.10
1.1
1.1
—
—
—
0
0
751
6762
1.94
8.97
6.1
5.4
1.93
1.94
mu/l
0.10
693
6227
196
1282
1.69
8.78
1.8
2.0
28.39
29.56
s
2.95
190
1242
138
818
1.82
8.72
8.5
8.4
120.60
120.18
g/l
0.09
138
801
648
5630
1.63
8.37
5.0
4.5
11.64
12.56
mm/h
0.87
597
5252
490
4001
1.53
8.30
8.7
7.4
1.21
1.21
mmol/l
0.71
421
3464
65
299
2.27
8.29
4.4
3.9
1.21
1.33
mmol/l
0.62
65
292
439
3511
1.52
8.13
5.4
5.2
35.67
35.43
g/l
0.42
416
3302
818
7663
2.74
7.99
27.0
22.7
81.00
79.41
umol/l
0.70
810
7576
449
3621
1.51
7.90
3.3
2.9
—
—
estimate
—
0
0
335
2544
1.52
7.84
3.6
3.3
1098.97
1384.47
ng/l
0.86
286
2217
290
2143
1.54
7.67
2.5
2.3
3.12
2.93
mg/l
0.62
265
1836
828
7828
3.14
7.49
32.2
26.5
134.26
134.70
g/l
0.36
819
7739
118
702
1.79
7.33
2.6
2.5
10.10
7.17
ug/l
0.28
101
630
527
4431
1.50
7.32
9.6
9.8
4.08
4.18
e9/l
0.47
474
3891
827
7823
3.03
7.29
32.0
26.3
247.25
246.55
e9/l
0.11
814
7672
827
7823
3.03
7.29
31.8
26.2
91.19
91.38
fl
0.56
817
7738
827
7825
3.02
7.25
32.3
26.8
40.15
40.21
%
0.11
817
7734
827
7825
3.02
7.25
31.9
26.3
4.47
4.46
e12/l
0.10
814
7653
251
1820
1.54
7.15
5.0
4.1
1.02
1.02
kg/l
0.26
155
1247
750
6880
1.76
6.64
7.2
6.7
39.97
39.44
mmol/mol
0.84
682
6427
742
6800
1.71
6.41
4.7
4.4
1.27
1.28
mmol/l
0.23
666
6239
94
544
1.82
6.39
10.7
6.4
24.64
24.57
mmol/l
0.07
94
520
655
5844
1.52
6.17
9.6
8.6
79.09
79.60
u/l
0.10
619
5547
641
5694
1.51
6.16
5.1
4.3
15.20
14.85
pmol/l
2.98
575
5192
770
7149
1.81
6.10
5.6
5.3
4.43
4.56
mmol/l
2.64
701
6658
806
7599
2.15
6.05
14.7
12.6
24.94
25.86
u/l
1.13
781
7389
766
7109
1.78
5.97
5.5
5.2
1.45
1.45
mmol/l
0.05
690
6571
778
7261
1.83
5.84
6.3
6.0
2.54
2.65
mmol/l
2.78
710
6729
230
1717
1.47
5.48
1.3
1.3
0.73
1.78
u/ml
2.38
71
468
487
4155
1.40
5.45
6.9
6.9
11.11
11.62
umol/l
0.63
462
3977
116
747
1.64
5.38
6.6
7.3
9.76
10.13
mmol/l
0.23
110
720
757
7040
1.68
5.36
5.8
5.4
5.93
5.98
mmol/l
0.48
685
6457
101
629
1.69
5.33
2.6
3.0
10.28
10.95
g/l
0.96
91
581
245
1865
1.44
5.24
3.0
2.7
4.34
5.47
e6/l
0.93
226
1700
189
1378
1.48
5.03
1.9
1.7
1240.71
1177.76
nmol/l
0.41
147
1045
311
2487
1.39
4.98
3.3
2.6
54.40
95.19
u/l
0.69
288
2318
250
1930
1.42
4.90
2.8
2.5
—
—
—
0
0
221
1675
1.43
4.78
1.7
1.7
57542340.72
16080839.72
pmol/l
0.32
179
1393
228
1742
1.42
4.71
1.8
1.7
1.20
1.31
mg/l
0.24
171
1359
25
100
2.55
4.41
3.0
2.8
13.42
19.87
mg/l
—
9
43
62
356
1.80
4.37
1.9
2.0
44.36
39.59
u/l
0.60
55
318
419
3590
1.33
4.07
3.5
3.1
140.99
134.13
ug/l
0.20
399
3337
187
1421
1.40
3.92
2.1
2.0
—
—
—
0
0
280
2282
1.34
3.76
3.5
3.3
0.34
0.45
e6/l
0.50
227
1691
160
1206
1.40
3.49
3.2
2.6
21.83
22.85
%
0.41
146
1129
57
344
1.70
3.43
1.1
1.0
—
—
—
0
0
170
1301
1.38
3.39
3.2
2.6
2.32
2.28
g/l
0.48
159
1207
181
1400
1.37
3.38
3.1
2.6
13.05
12.96
umol/l
0.05
167
1306
147
1099
1.41
3.36
6.9
5.8
1.05
1.03
mmol/l
0.41
136
1016
6
7
8.62
3.26
1.3
1.0
—
—
—
0
0
314
2647
1.30
3.21
3.6
3.5
64.59
94.41
e6/l
0.42
261
2041
14
50
2.83
3.10
2.0
1.7
—
—
—
0
0
21
94
2.27
2.98
1.1
1.1
—
—
—
0
0
132
993
1.39
2.91
5.2
4.9
32.83
31.84
%
0.45
94
661
238
1959
1.30
2.87
3.8
4.2
89.52
88.25
%
0.33
227
1924
539
4908
1.27
2.80
4.0
3.4
56.16
49.90
u/l
0.60
499
4627
89
628
1.47
2.79
2.3
3.0
63.63
65.91
ml/min/173m2
0.27
46
279
46
280
1.68
2.73
1.7
1.8
—
—
—
0
0
59
385
1.57
2.67
1.7
1.9
1.61
1.47
g/l
0.64
53
348
318
2737
1.26
2.64
3.2
3.6
2.35
2.35
mmol/l
0.15
288
2482
11
36
3.08
2.57
1.1
1.0
1861.55
1710.75
miu/ml
0.15
11
36
139
1079
1.34
2.52
1.9
1.9
—
—
—
0
0
132
1018
1.35
2.50
1.9
2.0
—
—
—
0
0
86
618
1.44
2.47
4.9
3.9
88.07
88.68
ng/l
0.02
74
549
84
602
1.44
2.45
1.3
1.4
—
—
—
0
0
10
32
3.15
2.44
2.0
1.3
—
—
—
0
0
474
4299
1.23
2.36
3.1
3.0
—
—
—
0
0
27
147
1.86
2.35
1.7
1.9
—
—
—
0
0
103
773
1.38
2.32
2.5
2.2
366.76
383.33
nmol/l
0.34
90
725
126
978
1.34
2.29
1.4
1.5
—
—
—
0
0
185
1515
1.28
2.28
1.5
1.5
2.37
2.51
g/l
0.54
116
910
163
1314
1.30
2.27
1.2
1.3
19.40
12.86
u/ml
0.27
61
486
62
427
1.49
2.23
1.5
1.5
—
—
—
0
0
39
242
1.64
2.20
1.5
1.5
0.00
0.11
iu/ml
—
5
34
95
711
1.38
2.19
1.8
3.3
67.45
66.62
g/l
0.55
86
665
46
299
1.57
2.16
1.3
1.2
2.43
1.58
u/ml
—
6
19
47
308
1.56
2.13
1.8
1.8
4.58
8.10
iu/ml
1.16
13
77
173
1418
1.28
2.12
3.1
3.1
1.27
1.00
e6/l
0.41
114
777
34
208
1.66
2.04
1.8
1.6
—
—
—
0
0
732
7014
1.31
2.03
18.8
16.6
78.18
79.50
ml/min/173m2
0.93
692
6537
322
2839
1.22
2.02
5.9
6.0
2.04
2.94
ug/l
1.64
288
2548
63
445
1.45
2.02
5.0
3.8
50.78
47.27
%
0.66
63
438
9
32
2.83
2.00
1.0
1.3
—
—
—
0
0
33
202
1.66
1.98
2.1
2.1
4.75
4.38
iu/l
—
7
78
8
27
2.98
1.94
1.6
1.1
—
—
—
0
0
280
2452
1.21
1.86
1.8
1.7
21.79
20.03
nmol/l
0.41
237
2071
18
93
1.96
1.86
1.2
1.3
0.15
0.19
nmol/l
1.76
13
70
116
922
1.30
1.81
2.8
2.3
158.30
137.25
ug/g
0.28
89
726
45
306
1.50
1.76
1.9
1.9
—
—
—
0
0
254
2216
1.21
1.74
3.9
3.4
2.40
0.06
estimate
0.48
104
703
35
226
1.57
1.73
1.6
1.7
—
—
—
0
0
107
848
1.30
1.71
4.6
3.4
—
—
—
0
0
80
608
1.35
1.71
1.7
1.7
—
—
—
0
0
34
220
1.57
1.67
1.6
1.7
—
—
—
0
0
8
31
2.60
1.66
1.4
2.0
—
—
—
0
0
8
31
2.60
1.66
1.4
2.0
—
—
—
0
0
38
253
1.53
1.66
1.4
1.4
1.17
1.19
g/l
0.18
38
244
37
245
1.53
1.65
1.4
1.4
0.23
0.24
g/l
0.35
37
235
31
197
1.60
1.64
1.2
1.2
—
—
—
0
0
166
1395
1.24
1.64
3.0
3.4
0.83
0.82
mmol/l
0.57
157
1315
31
198
1.59
1.62
1.4
1.4
—
—
—
0
0
5
14
3.59
1.61
1.0
1.1
—
—
—
0
0
13
63
2.08
1.60
1.0
1.0
—
—
—
0
0
8
32
2.51
1.60
1.4
2.0
—
—
—
0
0
27
168
1.63
1.57
1.5
1.5
—
—
—
0
0
82
636
1.32
1.55
4.6
3.9
1.23
1.22
mmol/l
0.10
73
548
23
138
1.69
1.53
1.4
1.6
—
—
—
0
0
390
3573
1.17
1.48
2.4
2.2
95.56
95.50
pmol/l
0.01
221
1912
61
459
1.35
1.42
12.2
9.9
15.63
15.78
%
0.18
61
441
33
222
1.51
1.40
1.2
1.2
0.98
2.26
u/ml
—
5
19
9
40
2.26
1.40
1.3
1.9
—
—
—
0
0
9
40
2.26
1.40
1.3
1.9
—
—
—
0
0
9
40
2.26
1.40
1.3
1.9
—
—
—
0
0
9
40
2.26
1.40
1.3
1.8
—
—
—
0
0
32
214
1.51
1.40
1.2
1.2
—
—
—
0
0
33
223
1.50
1.38
1.2
1.2
2.61
9.88
u/ml
—
8
36
166
1421
1.21
1.38
1.3
1.3
38.63
36.52
iu/ml
0.06
46
444
6
23
2.62
1.37
1.0
1.1
—
—
—
0
0
6
23
2.62
1.37
1.0
1.1
—
—
—
0
0
32
216
1.50
1.35
1.2
1.2
—
—
—
0
0
22
136
1.63
1.33
2.3
2.0
5.61
4.83
mmol/24h
0.44
16
120
102
833
1.26
1.32
4.9
3.6
1.31
1.88
mmol/l
0.59
95
708
6
24
2.51
1.30
1.0
1.2
—
—
—
0
0
22
137
1.62
1.30
1.3
1.3
—
—
—
0
0
50
371
1.37
1.29
2.5
1.8
5.14
2.22
ug/l
0.29
43
335
13
69
1.90
1.29
2.1
1.7
—
—
—
0
0
5
18
2.79
1.28
1.0
1.2
—
—
—
0
0
187
1630
1.19
1.28
3.0
3.0
2.44
2.45
mmol/l
0.77
172
1464
11
56
1.98
1.22
2.0
2.5
726.67
593.12
ml
—
6
34
13
71
1.84
1.20
1.3
1.7
—
—
—
0
0
13
71
1.84
1.20
1.3
1.7
—
—
—
0
0
13
71
1.84
1.20
1.3
1.7
—
—
—
0
0
26
173
1.52
1.19
2.1
3.2
0.75
0.86
nmol/l
0.83
16
142
6
26
2.32
1.19
1.0
1.2
—
—
—
0
0
17
102
1.68
1.17
3.2
2.0
89.61
89.66
%
0.01
17
102
37
266
1.41
1.16
1.4
1.3
—
—
—
0
0
39
284
1.39
1.14
1.5
4.4
35.20
49.41
mg/l
0.70
31
245
7
30
2.34
1.12
3.3
3.4
26.00
34.28
umol/l
—
7
23
68
544
1.27
1.07
4.4
3.1
129.29
127.53
g/l
0.23
68
532
57
447
1.29
1.05
3.7
3.5
4.43
4.50
pmol/l
0.22
48
393
11
60
1.84
1.03
1.2
1.2
—
—
—
0
0
305
2807
1.13
1.00
3.7
3.4
7.65
7.73
mmol/l
0.10
249
2370
38
283
1.36
1.00
1.5
4.4
80.08
70.84
mg/l
0.12
31
243
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
36
266
1.37
0.99
1.9
2.5
0.38
0.35
iu/ml
0.15
14
146
9
49
1.85
0.98
3.4
2.5
—
—
—
0
0
5
23
2.18
0.98
1.0
1.1
—
—
—
0
0
5
23
2.18
0.98
1.0
1.1
—
—
—
0
0
6
27
2.23
0.93
1.2
1.1
—
—
—
0
0
6
27
2.23
0.93
1.0
1.0
—
—
—
0
0
370
3461
1.12
0.92
2.8
2.4
78.67
77.25
nmol/l
0.44
335
3093
84
703
1.22
0.92
2.7
2.5
0.34
0.41
e6/l
0.16
84
673
227
2061
1.14
0.91
2.9
2.9
351.59
349.80
umol/l
0.09
205
1808
18
118
1.54
0.91
1.2
2.1
31.61
32.85
pg
0.37
18
118
17
111
1.54
0.88
1.2
1.2
—
20.50
—
0
6
14
87
1.62
0.88
1.3
1.9
—
—
—
0
0
16
103
1.56
0.88
1.1
1.0
—
—
—
0
0
106
913
1.18
0.86
2.4
2.8
6.94
8.48
umol/l
0.71
85
815
249
2283
1.13
0.86
5.2
4.9
22.69
21.16
%
0.91
132
1175
64
525
1.24
0.85
1.9
1.7
—
—
—
0
0
294
2724
1.12
0.85
4.6
4.2
13.50
8.43
mg/mmol
0.58
189
1723
27
196
1.39
0.85
1.5
1.5
—
—
—
0
0
13
80
1.63
0.85
1.3
2.0
—
—
—
0
0
10
57
1.76
0.84
1.0
1.2
—
—
—
0
0
19
270
0.70
0.80
1.4
1.8
2.98
3.82
mg/l
0.25
13
205
32
242
1.33
0.80
1.5
1.6
—
—
—
0
0
32
242
1.33
0.80
1.8
1.6
—
—
—
0
0
10
58
1.73
0.80
1.0
1.2
—
—
—
0
0
60
494
1.23
0.79
1.5
1.3
169.71
242.41
u/ml
0.46
55
453
15
98
1.54
0.79
3.1
2.9
1.18
1.19
mmol/l
0.43
15
98
32
243
1.33
0.78
1.5
1.4
284.14
290.33
ug/g
0.07
22
149
31
235
1.33
0.77
1.4
1.4
—
—
—
0
0
15
99
1.52
0.76
3.1
2.9
4.14
4.02
mmol/l
0.70
15
99
15
99
1.52
0.76
3.1
2.9
105.53
105.39
mmol/l
0.05
15
99
43
345
1.26
0.72
1.1
1.3
—
—
—
0
0
25
186
1.35
0.70
1.1
1.1
6.68
3.65
—
5
24
39
310
1.27
0.70
3.2
2.9
—
—
—
0
0
91
791
1.17
0.69
2.3
2.4
0.20
0.21
g/l
0.59
83
743
48
393
1.23
0.68
11.4
4.5
1.59
1.59
%
0.02
48
371
26
196
1.34
0.68
1.6
1.6
—
—
—
0
0
5
93
0.53
0.67
2.8
3.8
—
—
—
0
0
16
112
1.44
0.64
1.9
1.7
—
—
—
0
0
32
253
1.28
0.62
1.4
4.2
1.67
2.68
ratio
1.06
18
147
5
30
1.67
0.61
4.0
2.5
30.58
294.42
ug/l
—
5
25
8
52
1.54
0.59
1.9
1.7
—
—
—
0
0
134
1213
1.12
0.59
1.5
1.5
—
—
—
0
0
24
184
1.31
0.58
2.3
2.5
106.62
90.47
ug/min
0.11
13
102
7
116
0.60
0.58
1.1
1.6
—
—
—
0
0
6
37
1.63
0.55
2.5
4.5
—
—
—
0
0
22
168
1.32
0.55
1.5
1.5
—
—
—
0
0
58
498
1.18
0.54
3.7
3.7
1.41
1.87
mmol/l
0.57
44
380
7
45
1.56
0.49
1.0
1.1
—
—
—
0
0
13
93
1.40
0.48
1.9
1.7
—
—
—
0
0
31
257
1.21
0.43
1.6
1.6
33.86
12.94
u/ml
—
7
54
9
129
0.69
0.43
1.4
1.5
—
—
—
0
0
11
78
1.42
0.43
1.5
1.6
46.66
51.99
ug/l
0.17
11
78
11
151
0.72
0.43
1.5
1.3
—
—
—
0
0
11
151
0.72
0.43
1.5
1.3
—
—
—
0
0
164
1530
1.09
0.43
3.6
4.1
234.38
388.89
ng/l
0.40
125
1224
10
70
1.43
0.42
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
24
196
1.23
0.39
1.2
1.3
—
—
—
0
0
5
35
1.43
0.39
1.6
2.9
513.80
828.11
u/ml
—
5
35
244
2561
0.93
0.39
3.0
3.4
35.66
33.55
u/l
0.28
233
2421
44
504
0.87
0.38
1.6
1.8
3.39
3.48
mmol/l
0.19
28
368
5
36
1.39
0.38
1.2
2.5
176.80
199.94
u/l
—
5
36
5
36
1.39
0.38
1.0
1.3
11.00
10.25
mm/h
—
5
36
333
3205
1.06
0.38
1.8
2.0
1.35
1.33
mmol/l
0.10
267
2662
5
78
0.64
0.35
1.2
1.1
105.00
97.16
%
—
5
70
73
662
1.11
0.35
2.0
2.4
12.58
12.66
nmol/l
0.03
61
596
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
43
1.40
0.35
1.0
1.1
—
—
—
0
0
18
222
0.81
0.35
1.1
1.2
0.90
0.91
g/l
0.06
18
222
15
118
1.28
0.33
1.3
1.1
—
—
—
0
0
6
86
0.70
0.33
1.0
1.4
6.17
7.16
mmol/l
—
6
72
7
52
1.35
0.31
1.9
1.6
—
—
—
0
0
23
193
1.20
0.31
1.4
1.5
—
—
—
0
0
13
102
1.28
0.30
1.7
1.7
—
—
—
0
0
24
204
1.18
0.29
2.0
2.2
131.07
129.85
g/l
0.06
15
163
21
177
1.19
0.27
1.3
1.2
25.68
46.35
u/ml
—
5
20
20
168
1.20
0.27
19.8
6.5
10.65
11.21
mmol/l
0.39
20
152
20
168
1.20
0.27
19.8
6.5
107.90
105.22
mmol/l
1.51
20
152
24
207
1.16
0.25
1.2
1.3
—
—
—
0
0
92
862
1.08
0.24
4.3
4.5
175.95
25.66
ug/l
0.42
78
732
10
78
1.29
0.24
1.2
1.2
2.01
1.65
nmol/l
—
10
69
14
169
0.83
0.24
8.4
3.9
27.57
29.32
mg/l
—
7
114
14
115
1.22
0.23
2.1
1.6
—
—
—
0
0
14
115
1.22
0.23
1.2
1.5
—
—
—
0
0
62
670
0.92
0.23
1.8
2.1
3.45
3.47
ratio
0.04
48
532
18
211
0.85
0.23
1.1
1.2
1.56
1.55
g/l
0.04
18
211
7
92
0.76
0.22
1.3
1.3
—
—
—
0
0
5
40
1.25
0.22
1.0
1.5
—
—
—
0
0
5
40
1.25
0.22
1.4
1.6
39.26
40.38
g/l
—
5
40
5
41
1.22
0.22
1.2
1.3
209.00
160.44
pmol/l
—
5
41
0
11
0.00
0.21
0.0
1.1
—
1.17
—
0
11
125
1310
0.95
0.21
3.5
3.2
1.74
2.05
e6/l
0.27
66
666
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
26
230
1.13
0.21
1.7
1.3
—
—
—
0
0
6
51
1.18
0.19
2.0
1.6
—
—
—
0
0
35
318
1.10
0.19
2.7
2.0
—
—
—
0
0
6
53
1.13
0.18
1.2
1.4
—
58.33
—
0
6
24
213
1.13
0.18
1.3
1.3
207.17
225.24
miu/ml
—
6
101
175
1690
1.04
0.18
3.2
3.4
0.70
0.78
ug/l
0.75
122
1144
12
100
1.20
0.18
1.1
1.0
3.11
1.51
u/ml
—
5
47
16
139
1.15
0.16
1.0
1.1
27.91
17.92
au/ml
—
8
38
8
73
1.10
0.15
1.1
1.3
—
—
—
0
0
18
201
0.89
0.13
1.4
1.5
—
—
—
0
0
31
286
1.09
0.13
1.5
2.9
9.57
10.72
g/l
0.71
24
259
13
113
1.15
0.13
1.2
1.5
—
—
—
0
0
53
501
1.06
0.13
1.3
1.3
103.67
144.20
u/ml
0.31
21
206
13
115
1.13
0.10
1.2
1.5
—
—
—
0
0
17
154
1.11
0.10
3.1
3.0
7.64
8.70
pmol/l
0.24
17
154
5
44
1.14
0.10
1.4
1.2
—
—
—
0
0
5
44
1.14
0.10
1.4
1.2
—
—
—
0
0
68
654
1.04
0.10
2.1
2.1
—
—
—
0
0
36
381
0.94
0.09
3.1
2.1
—
—
—
0
0
6
57
1.05
0.08
1.0
1.1
—
—
—
0
0
6
58
1.03
0.08
1.0
1.1
—
—
—
0
0
6
58
1.03
0.08
1.0
1.1
—
—
—
0
0
30
283
1.06
0.08
1.5
1.3
30.03
27.94
iu/l
0.10
24
241
7
65
1.08
0.08
1.0
1.1
—
—
—
0
0
7
66
1.06
0.08
1.3
1.2
9.14
11.00
u/l
—
7
60
11
98
1.12
0.07
1.1
1.1
125.64
115.19
%
0.55
11
88
36
343
1.05
0.07
1.4
1.8
0.15
0.35
mg/l
2.69
13
157
12
108
1.11
0.07
1.0
1.1
1.49
1.54
g/l
0.28
12
97
16
147
1.09
0.07
1.6
1.5
—
—
—
0
0
10
89
1.13
0.07
3.9
2.9
—
—
—
0
0
24
252
0.95
0.05
1.3
1.4
—
—
—
0
0
29
302
0.96
0.04
1.6
3.0
2.63
1.23
g/l
0.49
24
267
24
230
1.04
0.03
1.5
1.6
889.71
906.84
mu/l
0.04
19
198
14
149
0.94
0.03
1.0
1.2
225.00
284.06
u/ml
—
7
78
13
123
1.06
0.01
1.1
1.1
0.14
2.02
u/ml
—
5
66
72
712
1.01
0.01
2.1
2.2
—
—
—
0
0
21
206
1.02
0.00
2.5
2.1
3858.78
5246.44
u/l
—
9
77
22
216
1.02
0.00
4.7
3.2
1.35
1.61
mmol/l
1.52
22
211
10
102
0.98
0.00
1.0
1.1
—
—
—
0
0
11
112
0.98
0.00
1.3
1.5
—
—
—
0
0
85
855
0.99
0.00
1.6
1.8
1.38
1.52
%
1.56
70
739
74
744
0.99
0.00
2.5
2.4
46.52
36.54
u/l
0.34
61
627
20
202
0.99
0.00
3.3
3.1
3.25
1.71
index
0.22
12
118
11
111
0.99
0.00
1.3
1.5
—
—
—
0
0
11
111
0.99
0.00
1.3
1.5
—
—
—
0
0
599
5989
1.00
0.00
22.4
21.1
13.78
13.69
%
0.89
590
5919
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
56
0.89
-0.00
1.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
7
79
0.89
-0.00
1.0
1.2
—
—
—
0
0
5
56
0.89
-0.00
1.0
1.4
—
—
—
0
0
6
60
1.00
-0.00
2.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
56
0.89
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
0.50
—
0
8
7
69
1.01
-0.00
1.0
1.4
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.1
95.00
103.10
pmol/l
—
5
58
0
8
0.00
-0.00
0.0
7.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
12.63
—
0
8
8
80
1.00
-0.00
1.1
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_PARASTRA4 and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRA4 | 1.027 [0.87, 1.22] | 0.763 |
| Birth year | 0.993 [0.98, 1.0] | 0.094 |
During the follow-up period (1.1.1998 — 31.12.2019), 244 out of 1915 females with H7_PARASTRA4 died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRA4 | 1.067 [0.92, 1.24] | 0.381 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 423 out of 2325 males with H7_PARASTRA4 died.
Mortality risk
Mortality risk for people of age
years, who have H7_PARASTRA4.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.062% | 0.187% |
| 5 | 0.54% | 1.149% |
| 10 | 1.428% | 2.73% |
| 15 | 2.727% | 5.162% |
| 20 | 4.625% | 8.737% |
Relationships between endpoints
↥Index endpoint: H7_PARASTRA4 – Fourth [trochlear] nerve palsy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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