No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
570 |
4. Check minimum number of eventsNone |
570 |
5. Include endpointsNone |
570 |
6. Filter based on genotype QC (FinnGen only) |
526 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Hypertrophy of tongue papillae
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2799 | 1597 | 1191 |
| Only index persons | 2669 | 1527 | 1142 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 55.06 | 55.67 | 54.28 |
| Only index persons | 55.73 | 56.39 | 54.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 526 | 328 | 198 |
| Unadjusted period prevalence (%) | 0.11 | 0.12 | 0.09 |
| Median age at first event (years) | 60.53 | 58.36 | 64.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 540
- Matched controls
- 5400
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K14.31
ICD-10 Finland
Coated tongue
+∞
205.8
184
*
K14.30
ICD-10 Finland
Black hairy tongue
+∞
191.4
172
*
K14.39
ICD-10 Finland
Papillary hypertrophy of the tongue UNS
+∞
104.7
97
*
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
25.4
98.5
71
32
K14.38
ICD-10 Finland
Other papillary hypertrophy of the tongue
+∞
54.1
51
*
K14.3
ICD-10 Finland
Hypertrophy of tongue papillae
+∞
33.7
32
*
A07AA02
ATC
nystatin; oral
5.2
32.8
74
161
SBA00
NOMESCO Finland
Microbiological examinations
8.6
29.0
38
47
D20
ICPC
Mouth/tongue/lip symptom/complaint
4.9
28.9
68
153
WZC00
NOMESCO Finland
Treatment plan or consultation
2.6
26.3
265
1455
SAA02
NOMESCO Finland
Basic examination of mouth
2.9
23.9
427
3034
K13.78
ICD-10 Finland
Other change in the oral mucosa
6.6
23.0
38
61
SAA01
NOMESCO Finland
Simple examination of mouth
2.9
20.0
446
3363
Z01.2
ICD-10 Finland
Dental examination
2.3
18.8
302
1945
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
18.8
278
1733
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
2.2
18.0
298
1932
SAA03
NOMESCO Finland
Extended examination of mouth
2.2
17.7
259
1596
A01AB09
ATC
miconazole; local oral
3.2
17.6
76
262
B37.0
ICD-10 Finland
Candidal stomatitis
13.2
17.3
30
24
K02.0
ICD-10 Finland
Caries limited to enamel
2.4
17.2
148
729
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
4.9
16.4
37
80
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
2.1
15.8
337
2364
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
15.5
185
1039
SFA10
NOMESCO Finland
One-surface restoration
2.1
15.4
340
2406
K02.1
ICD-10 Finland
Caries of dentine
2.1
15.0
360
2618
WX110
NOMESCO Finland
Infiltration anesthesia
2.3
14.5
424
3307
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
2.2
14.4
148
780
SDA03
NOMESCO Finland
Periodontal treatment
2.0
14.1
260
1704
EJB10
NOMESCO Finland
Excision of tumor or other lesion of apex or body of tongue
24.5
13.9
19
8
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
2.0
13.6
299
2074
SDA04
NOMESCO Finland
Demanding periodontal treatment
2.1
13.6
192
1140
K14.1
ICD-10 Finland
Geographic tongue
35.0
13.6
17
5
SXC05
NOMESCO Finland
Other oral or dental procedure
3.3
13.5
54
177
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
13.1
224
1420
K03.64
ICD-10 Finland
Dental calculus supragingival
2.0
12.8
208
1294
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.0
12.7
194
1180
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
4.4
12.6
32
76
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.9
12.6
262
1770
K14.32
ICD-10 Finland
Hypertrophy of papillae foliatae
+∞
12.5
12
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
12.4
93
425
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
2.5
12.1
82
357
A02BC05
ATC
esomeprazole; systemic
1.9
11.7
239
1594
SFA20
NOMESCO Finland
Two-surface restoration
1.9
11.6
347
2611
D82
ICPC
Teeth/gum disease
1.9
11.5
232
1536
J02AC01
ATC
fluconazole; systemic
1.9
11.4
241
1620
B37.09
ICD-10 Finland
Unspecified candidal stomatitis
10.9
11.4
21
20
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
11.2
143
809
K03.66
ICD-10 Finland
Tooth plaque
2.7
11.0
61
240
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
11.0
274
1932
A02BC02
ATC
pantoprazole; systemic
1.9
11.0
384
3015
R20.2
ICD-10 Finland
Paraesthesia of skin
2.9
10.9
54
200
K02.8
ICD-10 Finland
Other dental caries
4.6
10.8
26
59
WZA90
NOMESCO Finland
Other medical or dental certificate
2.0
10.8
155
913
SDA02
NOMESCO Finland
Periodontal treatment, brief
1.9
10.7
218
1441
B37.08
ICD-10 Finland
Other candidal stomatitis
11.5
10.6
19
17
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.0
10.1
46
163
SCA01
NOMESCO Finland
Preventive oral health care, short
1.9
10.0
179
1131
SPAT1263
SPAT
Sampling
1.8
10.0
241
1670
E0000UV, ,
ATC
1.8
9.9
243
1689
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
9.7
162
999
A01AB04
ATC
amphotericin B; local oral
3.1
9.6
40
134
C05AA08
ATC
fluocortolone; rectal, topical
2.2
9.3
84
414
UJF32
NOMESCO Finland
Coloscopy
1.9
9.2
149
909
M54.5
ICD-10 Finland
Low back pain
1.8
9.1
212
1444
SFA00
NOMESCO Finland
Small restoration
2.1
9.1
91
468
S18
ICPC
Laceration/cut
1.7
9.1
272
1989
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
9.0
68
310
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
8.9
143
867
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.2
8.9
82
408
K08.80
ICD-10 Finland
Toothache NOS
2.4
8.9
63
280
A02BA02
ATC
ranitidine; systemic
2.0
8.8
111
621
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.9
8.8
128
753
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.9
8.6
40
143
R13
ICD-10 Finland
Dysphagia
2.6
8.6
49
196
F45.8
ICD-10 Finland
Other somatoform disorders
2.6
8.5
50
203
SDA01
NOMESCO Finland
Periodontal treatment, very brief
1.8
8.5
166
1069
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.0
8.3
37
129
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
1.8
8.3
140
862
H02AB06
ATC
prednisolone; systemic
1.7
8.2
266
1967
SFA30
NOMESCO Finland
Three-surface restoration
1.7
8.0
243
1762
WX290
NOMESCO Finland
Other blockage of nerve
1.7
7.9
276
2075
H92.0
ICD-10 Finland
Otalgia
2.6
7.9
45
180
M79.6
ICD-10 Finland
Pain in limb
1.7
7.8
252
1855
K14.9
ICD-10 Finland
Disease of tongue, unspecified
45.6
7.7
9
*
K59.0
ICD-10 Finland
Constipation
2.7
7.7
42
164
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.8
7.7
157
1019
EJ1S1
NOMESCO Finland
Photography of tongue
18.7
7.6
11
6
R95
ICPC
Chron obstructive pulmonary disease
3.9
7.6
22
58
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.2
7.6
67
327
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
7.5
189
1299
R03BA01
ATC
beclometasone; inhalant
2.0
7.5
82
434
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.2
7.5
63
301
SPAT1153
SPAT
Removal of sutures
1.7
7.5
174
1172
SPAT1312
SPAT
General health counselling
1.7
7.4
177
1198
JN3AD
NOMESCO Finland
Abdominal CT examination
2.1
7.4
79
414
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.7
7.4
155
1013
J01FF01
ATC
clindamycin; systemic
1.7
7.4
155
1014
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.7
7.3
221
1592
D10.12
ICD-10 Finland
Bone tumor of the tip of the tongue
+∞
7.3
7
*
L17
ICPC
Foot/toe symptom/complaint
1.7
7.3
180
1230
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
7.3
104
605
R07.0
ICD-10 Finland
Pain in throat
2.5
7.2
45
188
K03.00
ICD-10 Finland
Approximal wear
2.4
7.2
53
239
EKA10
NOMESCO Finland
iopsy of buccal mucosa
4.0
7.2
20
51
N30.0
ICD-10 Finland
Acute cystitis
1.9
7.2
99
569
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
7.1
86
472
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.4
7.1
49
215
P01AB01
ATC
metronidazole; oral, rectal
1.6
7.1
226
1647
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.3
7.1
26
81
K05.30
ICD-10 Finland
Periodontitis complex
1.9
6.9
93
529
D07AC01
ATC
betamethasone; topical
1.6
6.9
199
1412
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
6.9
228
1674
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
6.9
160
1073
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.2
6.8
60
292
L57.0
ICD-10 Finland
Actinic keratosis
2.1
6.8
63
314
N02AX02
ATC
tramadol; systemic, rectal
1.6
6.7
231
1709
J01DB01
ATC
cefalexin; oral
1.8
6.7
448
3916
K10.00
ICD-10 Finland
Torus mandibularis
8.0
6.6
14
18
KMAK, ,
NOMESCO Finland
1.6
6.6
275
2126
S29
ICPC
Skin symptom/complaint other
1.8
6.6
119
743
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
6.5
108
656
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
6.5
164
1120
A02BC03
ATC
lansoprazole; oral
1.7
6.5
153
1027
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.9
6.5
95
556
A04
ICPC
Weakness/tiredness general
1.9
6.4
89
511
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
3.8
6.4
19
51
D19
ICPC
Teeth/gum symptom/complaint
1.6
6.4
177
1238
H02AB04
ATC
methylprednisolone; systemic
1.9
6.4
82
459
Z75.1
ICD-10 Finland
Person awaiting admission to adequate facility elsewhere
3.4
6.3
22
66
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
6.3
108
662
R52.9
ICD-10 Finland
Pain, unspecified
2.0
6.3
68
358
H29
ICPC
Ear symptom/complaint other
2.0
6.3
73
395
K59.09
ICD-10 Finland
Constipation, unspecified
2.4
6.3
45
201
B37.02
ICD-10 Finland
Chronic hyperplastic candidal stomatitis
+∞
6.3
6
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
6.3
239
1805
M54.6
ICD-10 Finland
Pain in thoracic spine
2.3
6.2
49
228
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
3.6
6.2
20
57
AA1AD
NOMESCO Finland
CT of head and brain
1.7
6.2
153
1038
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.7
6.1
130
848
SPAT1301
SPAT
No procedures
1.6
6.1
167
1163
K05.31
ICD-10 Finland
Periodontitis pronounced
2.0
6.1
68
363
EJ2S1
NOMESCO Finland
Photography of oral mucosa
10.2
6.1
11
11
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.2
6.0
53
258
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.3
6.0
45
205
SDA05
NOMESCO Finland
Very demanding periodontal treatment
2.3
6.0
45
205
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
46
55
9.05
36.11
1.4
1.2
—
—
—
0
0
304
2070
2.07
15.19
6.0
4.8
36.60
35.98
g/l
1.24
284
1957
446
3575
2.42
13.92
5.8
4.4
12.33
11.53
mm/h
0.51
416
3336
448
3645
2.34
12.71
10.7
8.3
80.98
77.58
u/l
0.69
432
3463
224
1472
1.89
11.37
2.7
2.1
158.11
231.63
u/l
0.74
212
1396
123
671
2.08
10.60
2.6
2.3
173.96
109.33
ug/g
0.52
100
532
361
2813
1.85
10.13
6.1
5.1
6.52
6.65
mmol/l
0.64
347
2648
360
2806
1.85
10.05
12.3
9.7
4.18
4.07
e9/l
0.40
320
2461
342
2629
1.82
9.94
4.5
3.8
0.00
0.60
estimate
0.51
73
514
228
1558
1.80
9.84
3.6
2.5
55.57
62.12
u/l
0.83
217
1459
335
2568
1.80
9.73
7.3
6.6
10.61
11.13
umol/l
0.28
319
2462
316
2385
1.78
9.64
10.2
7.2
1.21
1.21
mmol/l
0.15
269
2056
336
2584
1.79
9.59
4.3
3.8
0.00
0.00
estimate
0.50
76
541
338
2605
1.80
9.57
4.4
3.8
17.21
2.96
estimate
0.38
77
549
297
2211
1.76
9.41
3.1
2.4
79.06
77.07
nmol/l
0.63
271
1987
185
1234
1.76
8.37
2.3
2.2
2.87
2.94
mg/l
0.13
161
1080
443
3777
1.96
8.33
5.3
4.4
14.80
14.75
pmol/l
0.16
410
3480
383
3125
1.78
8.27
5.6
4.5
7.60
1122.61
e6/l
—
5
41
285
2146
1.69
8.25
16.1
12.4
1.19
1.20
inr
0.11
244
1766
285
2158
1.68
7.98
8.9
6.4
1.21
1.21
mmol/l
0.41
263
1988
263
1959
1.67
7.78
4.0
3.7
0.07
0.01
estimate
0.49
61
453
494
4417
2.39
7.70
6.8
5.4
1.82
1.89
mu/l
0.80
463
4105
231
1675
1.66
7.50
3.9
3.3
2.36
2.36
mmol/l
0.08
209
1526
69
346
2.14
7.29
1.8
1.5
—
—
—
0
0
512
4689
2.77
6.91
22.5
15.1
20.44
22.67
mg/l
1.02
447
3826
392
3291
1.70
6.87
4.1
3.3
47.53
45.33
u/l
0.23
367
3117
176
1213
1.67
6.82
1.4
1.3
3.53
1.54
u/ml
0.47
47
323
137
883
1.74
6.79
1.3
1.3
2.64
12.50
u/ml
3.73
53
340
146
970
1.69
6.44
1.9
1.6
—
—
—
0
0
100
605
1.80
6.11
9.0
5.5
1.06
1.03
mmol/l
0.43
92
567
66
348
2.02
6.10
1.3
1.3
212.57
275.24
u/ml
0.23
57
323
197
1435
1.59
5.95
4.0
3.9
0.00
0.00
estimate
0.80
73
514
118
759
1.71
5.81
1.7
1.7
1159.02
1219.47
nmol/l
0.27
90
582
487
4425
2.02
5.73
7.2
6.3
38.97
39.01
mmol/mol
0.04
461
4182
239
1841
1.53
5.53
4.7
3.7
27.17
68.55
ng/l
0.72
164
1295
192
1415
1.55
5.40
3.0
3.4
957.01
1059.87
ng/l
0.22
154
1208
116
759
1.67
5.33
2.4
2.0
—
—
—
0
0
511
4753
2.40
5.25
24.7
17.9
3.96
3.96
mmol/l
0.11
505
4649
68
383
1.89
5.20
2.1
3.2
66.86
67.11
g/l
0.10
63
363
152
1072
1.58
5.14
2.6
2.5
6.02
5.73
e6/l
0.08
143
978
141
980
1.59
5.07
1.9
1.7
452.89
8859661.44
pmol/l
0.50
110
824
220
1688
1.51
5.07
3.3
3.3
31.89
31.98
u/l
0.01
215
1599
510
4750
2.33
5.04
24.6
17.7
139.74
139.69
mmol/l
0.18
504
4657
139
964
1.60
5.04
1.4
1.3
32.06
36.90
iu/ml
0.17
32
294
192
1436
1.52
4.97
3.3
3.1
0.05
0.06
estimate
0.06
59
445
105
682
1.67
4.94
3.8
2.4
22.41
22.89
%
0.16
100
643
180
1335
1.52
4.82
3.3
3.1
0.24
0.36
e6/l
0.80
142
971
492
4535
1.96
4.80
5.9
5.1
5.88
5.91
mmol/l
0.15
458
4201
69
404
1.81
4.67
1.5
1.4
—
—
—
0
0
203
1552
1.49
4.67
3.3
3.2
210.85
97.49
e6/l
0.26
165
1182
135
947
1.57
4.62
2.7
2.8
2.46
2.45
mmol/l
0.26
120
857
93
596
1.68
4.59
2.1
2.2
—
—
—
0
0
48
252
1.99
4.51
1.6
1.4
—
—
—
0
0
119
816
1.59
4.48
3.8
3.5
0.83
0.82
mmol/l
0.16
109
779
86
549
1.67
4.30
2.1
2.1
—
—
—
0
0
156
1147
1.51
4.27
4.5
3.9
1.02
1.02
kg/l
0.88
108
757
115
791
1.58
4.26
4.1
2.4
13.65
13.49
umol/l
0.09
109
739
259
2112
1.43
4.12
2.7
2.1
100.53
96.87
pmol/l
0.64
153
1103
72
446
1.71
4.03
3.1
2.3
0.22
0.22
g/l
0.07
66
422
43
228
1.96
3.95
2.1
1.4
0.32
0.33
mg/l
0.00
24
93
64
387
1.74
3.90
3.1
2.9
62.88
66.33
ml/min/173m2
0.31
26
171
32
154
2.15
3.81
2.0
1.8
—
—
—
0
0
33
161
2.12
3.79
1.3
1.2
41.86
6.26
u/ml
—
5
29
30
143
2.16
3.66
3.5
3.2
1.69
1.47
mg/l
0.47
30
128
518
4941
2.19
3.35
16.4
12.0
26.27
26.40
u/l
0.06
508
4813
85
576
1.56
3.34
2.0
1.9
—
—
—
0
0
149
1136
1.43
3.29
1.8
1.7
1.12
1.31
mg/l
0.52
110
882
87
597
1.55
3.23
1.9
1.7
1.59
1.49
%
0.57
78
522
280
2378
1.37
3.23
3.9
3.0
120.25
115.98
ug/l
0.13
261
2236
26
125
2.13
3.13
1.2
1.1
8.28
7.36
eliau/ml
—
5
15
80
546
1.55
3.05
8.6
6.6
—
—
—
0
0
44
257
1.78
3.05
1.1
1.0
—
—
—
0
0
484
4546
1.62
2.99
19.2
14.5
82.95
82.72
ml/min/173m2
0.09
454
4197
268
2279
1.35
2.98
3.2
2.7
—
—
estimate
—
0
0
156
1219
1.39
2.96
2.9
2.8
341.60
341.00
umol/l
0.02
131
1085
31
164
1.94
2.92
2.3
2.7
0.47
1.07
g/l
0.61
26
150
529
5114
2.69
2.88
34.4
23.2
256.27
252.13
e9/l
0.75
524
5028
31
166
1.92
2.82
3.1
2.0
—
—
—
0
0
529
5117
2.66
2.81
34.2
23.2
4.48
4.50
e12/l
0.71
521
5019
38
218
1.80
2.80
2.1
2.2
13.89
7.54
iu/ml
—
8
57
110
816
1.44
2.79
1.4
1.5
—
—
—
0
0
176
1415
1.36
2.78
1.9
1.6
20.90
20.55
nmol/l
0.10
148
1202
31
167
1.91
2.78
1.9
2.1
260.71
544.35
ug/l
0.48
31
157
110
817
1.44
2.77
3.1
2.9
0.92
0.90
e6/l
0.05
62
429
58
376
1.61
2.76
2.3
2.3
11.83
13.40
nmol/l
0.58
50
345
17
72
2.41
2.75
1.2
1.1
0.83
1.72
eliau/ml
—
8
31
44
267
1.71
2.69
1.7
1.7
—
—
—
0
0
17
73
2.37
2.67
1.1
1.0
0.54
1.66
u/ml
1.28
11
36
43
260
1.71
2.67
1.8
1.3
—
—
—
0
0
12
43
2.83
2.66
1.1
1.1
125.83
109.23
pmol/l
0.72
12
43
68
462
1.54
2.65
9.3
9.5
117.46
121.55
g/l
0.84
68
453
21
100
2.14
2.62
1.1
1.1
0.43
1.39
u/ml
1.30
11
55
68
464
1.53
2.60
4.6
3.2
1.76
1.90
mmol/l
0.15
61
399
51
325
1.63
2.60
10.6
9.3
1.51
1.34
%
0.65
51
320
55
358
1.60
2.58
1.2
1.2
191.13
151.06
u/ml
0.19
17
146
148
1173
1.36
2.53
3.0
2.3
—
—
—
0
0
76
536
1.49
2.50
8.7
8.9
0.79
0.88
mmol/l
0.06
66
455
55
362
1.58
2.47
6.0
3.4
91.60
75.59
ng/l
0.55
44
319
51
331
1.60
2.43
2.1
2.0
—
—
—
0
0
339
3035
1.31
2.42
3.5
3.2
—
—
—
0
0
27
147
1.88
2.37
1.4
1.2
—
—
—
0
0
29
162
1.83
2.36
3.9
2.9
—
—
—
0
0
72
511
1.47
2.30
2.7
2.0
392.13
376.00
nmol/l
0.32
67
482
76
547
1.45
2.26
8.7
8.7
12.04
12.17
kpa
0.10
76
531
28
157
1.83
2.26
6.0
3.8
1.12
1.37
mmol/l
1.33
28
150
29
165
1.80
2.24
2.1
2.4
9.55
10.43
g/l
0.62
24
154
5
9
5.59
2.22
1.0
1.1
—
—
—
0
0
75
542
1.45
2.19
2.1
1.9
—
—
—
0
0
78
568
1.44
2.19
2.9
2.7
5.76
7.84
umol/l
1.02
65
509
14
61
2.33
2.16
1.1
1.0
0.01
0.96
u/ml
—
6
20
68
484
1.46
2.15
4.4
4.7
5.01
15.18
ug/l
0.61
57
402
41
262
1.61
2.10
4.4
3.8
1.79
1.84
mmol/l
0.03
35
197
19
96
2.01
2.08
1.4
1.3
188.30
260.72
u/ml
—
10
46
26
147
1.81
2.06
1.4
1.2
—
—
—
0
0
44
289
1.57
2.02
9.2
7.9
25.10
24.51
mmol/l
0.57
44
275
80
594
1.41
2.02
5.5
4.8
32.96
32.11
%
0.27
57
386
25
141
1.81
2.00
1.1
1.2
—
—
—
0
0
15
70
2.18
2.00
1.1
1.4
—
—
—
0
0
47
315
1.54
1.99
3.0
3.6
125.41
199.32
ng/l
1.41
39
287
5
11
4.58
1.94
1.0
1.6
0.70
0.46
e9/l
—
5
11
26
151
1.76
1.90
2.0
1.4
342.71
304.71
ug/g
0.32
14
94
469
4459
1.39
1.86
5.0
4.3
1.27
1.28
mmol/l
0.10
440
4145
5
12
4.19
1.82
1.0
1.3
—
—
—
0
0
114
913
1.32
1.79
4.6
3.9
457.94
353.53
ng/l
0.12
85
696
488
4679
1.45
1.77
6.2
5.1
4.56
4.66
mmol/l
1.28
464
4397
12
54
2.25
1.75
1.1
1.1
—
94.40
—
0
5
493
4738
1.47
1.74
6.8
5.8
2.67
2.73
mmol/l
0.74
468
4436
41
276
1.53
1.72
2.2
1.9
—
—
—
0
0
5
13
3.87
1.72
1.4
1.0
—
—
—
0
0
237
2095
1.23
1.63
2.2
1.9
1.32
1.34
mmol/l
0.15
197
1759
95
753
1.32
1.61
3.1
3.0
2.37
2.26
e6/l
0.06
47
364
39
265
1.51
1.58
3.4
2.4
0.67
0.61
%
0.82
39
265
92
728
1.32
1.58
1.8
2.1
29.95
29.36
s
0.40
85
706
5
15
3.35
1.52
4.6
2.6
0.59
0.61
mmol/l
—
5
15
51
369
1.42
1.52
2.4
2.6
3.52
6.65
ug/l
2.36
44
334
26
162
1.64
1.52
1.3
1.3
—
—
—
0
0
28
178
1.60
1.52
3.0
1.9
254.18
4981.86
u/l
—
9
71
6
21
2.88
1.51
1.0
1.3
—
—
—
0
0
17
94
1.83
1.49
2.7
1.9
4.58
5.14
mmol/24h
0.32
17
82
485
4668
1.38
1.49
6.0
5.0
1.45
1.48
mmol/l
0.88
458
4366
9
37
2.46
1.48
1.2
1.0
—
—
—
0
0
23
140
1.67
1.47
1.5
1.3
—
—
—
0
0
6
22
2.75
1.44
5.0
2.0
—
—
—
0
0
6
22
2.75
1.44
5.0
2.0
—
—
—
0
0
183
1593
1.23
1.42
4.9
4.1
10.60
8.20
mg/mmol
0.29
107
974
6
23
2.63
1.37
5.0
1.9
—
—
—
0
0
190
1669
1.21
1.34
4.4
3.3
6.79
7.65
mmol/l
2.27
161
1412
6
24
2.52
1.30
1.2
3.5
2754.67
638.25
u/ml
—
6
24
5
18
2.79
1.28
1.2
2.3
43.12
42.43
g/l
—
5
18
5
18
2.79
1.28
2.6
6.0
—
—
—
0
0
9
44
2.06
1.27
2.4
2.4
—
—
—
0
0
149
1284
1.22
1.26
5.9
5.5
1.80
2.55
ug/l
1.07
140
1163
16
92
1.76
1.26
2.9
1.4
179.40
163.44
au/ml
—
5
26
22
139
1.61
1.25
2.2
4.7
1.57
2.29
ratio
0.72
14
80
6
25
2.42
1.24
2.8
1.6
96.52
78.38
ng/l
—
6
25
26
172
1.54
1.23
1.4
1.5
—
—
—
0
0
14
78
1.82
1.22
1.4
1.4
—
—
—
0
0
14
78
1.82
1.22
1.4
1.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
127
1.60
1.13
2.4
2.4
0.31
0.37
iu/ml
—
9
65
39
522
0.73
1.12
2.4
2.0
3.58
3.50
ratio
0.14
28
424
27
185
1.48
1.10
1.6
1.6
—
—
—
0
0
5
21
2.39
1.09
1.2
1.3
—
—
—
0
0
7
32
2.20
1.08
23.7
17.2
1297.29
959.47
nmol/l
—
7
32
13
75
1.75
1.03
1.3
1.3
—
—
—
0
0
11
60
1.85
1.03
1.0
1.1
—
—
—
0
0
26
180
1.47
1.02
1.5
1.6
10.18
8.12
u/ml
—
6
35
58
461
1.29
1.00
3.4
2.5
28.10
33.03
u/l
1.02
50
386
10
54
1.87
0.97
1.1
1.1
—
—
—
0
0
13
77
1.71
0.96
1.3
1.3
—
—
—
0
0
13
77
1.71
0.96
1.3
1.3
—
—
—
0
0
23
158
1.48
0.95
1.4
1.4
—
—
—
0
0
10
55
1.83
0.92
3.2
4.1
—
—
—
0
0
11
63
1.76
0.90
1.0
1.1
—
—
—
0
0
6
29
2.08
0.89
5.0
1.8
—
—
—
0
0
6
29
2.08
0.89
5.0
1.8
—
—
—
0
0
6
29
2.08
0.89
5.0
1.8
—
—
—
0
0
6
29
2.08
0.89
5.0
1.8
—
—
—
0
0
19
128
1.50
0.87
1.3
1.2
—
—
—
0
0
6
31
1.95
0.84
3.8
2.1
457.33
533.04
e6/l
—
6
25
59
485
1.24
0.80
3.6
3.2
—
—
—
0
0
134
1191
1.17
0.80
5.4
3.9
94.03
91.29
%
0.65
127
1175
35
269
1.32
0.80
8.9
11.4
15.35
15.83
%
0.54
35
259
11
66
1.68
0.79
2.7
2.7
104.45
105.55
mmol/l
0.49
11
66
11
66
1.68
0.79
2.7
2.7
1.19
1.19
mmol/l
0.03
11
66
11
66
1.68
0.79
2.7
2.7
4.12
3.98
mmol/l
0.59
11
66
12
74
1.64
0.78
1.3
1.3
—
—
—
0
0
12
74
1.64
0.78
1.3
1.3
—
—
—
0
0
22
157
1.42
0.78
1.4
1.3
—
—
—
0
0
6
34
1.77
0.76
1.3
1.1
—
—
—
0
0
9
53
1.71
0.75
1.1
1.1
—
—
—
0
0
12
75
1.61
0.75
1.3
1.3
—
—
—
0
0
7
38
1.85
0.73
1.1
1.4
—
—
—
0
0
5
25
2.01
0.73
1.0
1.1
1.05
1.08
ratio
—
5
20
9
56
1.62
0.72
3.7
2.1
—
—
—
0
0
19
134
1.43
0.72
1.2
1.3
—
—
—
0
0
16
110
1.47
0.69
1.6
1.4
—
—
—
0
0
11
69
1.61
0.69
1.5
1.2
—
—
—
0
0
7
43
1.64
0.67
1.1
1.3
—
78.00
—
0
5
16
111
1.45
0.66
2.8
2.0
185.50
221.04
pmol/l
0.69
16
104
31
391
0.78
0.64
2.2
1.8
3.41
3.49
mmol/l
0.14
18
296
8
51
1.58
0.60
4.0
1.7
—
—
—
0
0
8
51
1.58
0.60
4.0
1.7
—
—
—
0
0
8
51
1.58
0.60
4.0
1.7
—
—
—
0
0
11
72
1.54
0.59
1.6
1.4
—
—
—
0
0
19
141
1.36
0.57
2.8
1.7
—
—
—
0
0
13
90
1.46
0.56
1.5
1.5
—
—
—
0
0
9
62
1.46
0.53
3.8
2.0
—
—
—
0
0
14
100
1.41
0.52
1.3
1.5
—
—
—
0
0
6
40
1.51
0.51
1.0
1.0
283.33
282.44
ng/l
—
6
27
6
41
1.47
0.50
1.2
1.1
—
—
—
0
0
6
41
1.47
0.50
1.2
1.1
—
—
—
0
0
17
127
1.35
0.50
3.0
3.0
1.00
1.86
index
—
10
79
7
110
0.63
0.49
1.4
1.6
—
—
—
0
0
31
254
1.23
0.48
1.4
1.3
35.90
26.63
iu/l
0.64
22
221
16
120
1.34
0.46
1.3
1.5
—
—
—
0
0
10
69
1.46
0.44
1.0
1.0
—
—
—
0
0
5
31
1.62
0.43
1.8
1.3
—
—
—
0
0
5
31
1.62
0.43
1.8
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
4.5
—
10.65
—
0
15
0
15
0.00
0.41
0.0
1.1
—
410.14
—
0
7
0
15
0.00
0.41
0.0
4.5
—
4.70
—
0
15
110
1014
1.11
0.40
5.0
4.6
20.63
21.41
%
0.20
58
482
0
18
0.00
0.40
0.0
1.1
—
40.09
—
0
18
19
236
0.80
0.38
1.5
1.6
1126.14
936.94
mu/l
—
10
203
13
98
1.33
0.37
1.2
1.4
—
—
—
0
0
5
79
0.63
0.35
1.0
1.1
—
—
—
0
0
16
126
1.28
0.35
1.9
1.5
17036.91
11840.70
e6/l
0.37
11
96
43
377
1.15
0.35
3.6
3.9
1.21
1.23
mmol/l
0.96
38
328
6
43
1.40
0.35
1.2
1.1
—
—
—
0
0
6
43
1.40
0.35
1.2
1.1
—
—
—
0
0
7
52
1.35
0.31
1.1
1.1
—
—
—
0
0
7
97
0.72
0.31
1.1
1.7
—
—
—
0
0
15
121
1.25
0.28
1.2
1.2
4.10
3.68
mmol/l
1.24
15
111
11
85
1.30
0.28
3.5
1.8
—
—
—
0
0
8
63
1.27
0.28
1.3
1.1
—
—
—
0
0
9
76
1.19
0.24
2.2
1.8
—
—
—
0
0
6
83
0.72
0.24
1.2
1.2
—
2.32
—
0
25
5
38
1.32
0.23
1.4
1.8
—
—
—
0
0
16
134
1.20
0.23
2.6
1.6
—
—
—
0
0
5
42
1.19
0.21
1.0
1.0
—
—
—
0
0
25
220
1.14
0.21
4.9
6.7
1.77
1.53
%
0.54
25
207
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
12
98
1.23
0.21
2.4
2.9
5.90
8.11
pmol/l
0.97
12
98
6
48
1.25
0.20
1.2
1.1
—
—
—
0
0
6
50
1.20
0.19
1.2
1.1
—
—
—
0
0
10
81
1.24
0.19
1.3
1.5
—
—
—
0
0
5
46
1.09
0.09
1.2
1.7
—
—
—
0
0
14
126
1.11
0.09
1.7
1.6
—
—
—
0
0
5
60
0.83
0.08
1.2
1.5
—
—
—
0
0
5
62
0.80
0.08
1.2
1.5
—
—
—
0
0
17
157
1.09
0.07
1.8
1.3
—
—
—
0
0
13
119
1.09
0.06
1.4
1.6
—
—
—
0
0
13
121
1.08
0.03
1.4
1.6
1.47
1.15
ratio
—
7
79
13
121
1.08
0.03
1.4
1.6
0.94
0.99
ratio
—
7
79
13
121
1.08
0.03
1.4
1.6
1.12
1.18
ratio
—
7
79
11
118
0.93
0.03
1.5
1.9
—
—
—
0
0
17
178
0.95
0.02
1.1
1.1
1.51
1.56
g/l
0.23
17
178
20
192
1.04
0.02
1.2
1.9
—
—
—
0
0
76
769
0.99
0.01
3.5
3.2
0.64
0.75
ug/l
1.06
62
498
18
185
0.97
0.00
1.3
1.1
0.91
0.92
g/l
0.02
18
185
17
174
0.98
0.00
1.4
1.3
181.57
262.19
miu/ml
—
7
91
0
9
0.00
0.00
0.0
8.3
—
10.23
—
0
9
0
9
0.00
0.00
0.0
2.2
—
1.28
—
0
9
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
94.45
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
63.83
—
0
6
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
6
63
0.95
-0.00
2.7
2.2
12.50
13.27
%
—
6
63
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_HYPERTROPHY_TONGUE_PAPILLAE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_HYPERTROPHY_TONGUE_PAPILLAE | 1.156 [0.89, 1.5] | 0.272 |
| Birth year | 0.998 [0.99, 1.01] | 0.573 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 1269 females with K11_HYPERTROPHY_TONGUE_PAPILLAE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_HYPERTROPHY_TONGUE_PAPILLAE | 1.423 [1.07, 1.89] | 0.014 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 126 out of 937 males with K11_HYPERTROPHY_TONGUE_PAPILLAE died.
Mortality risk
Mortality risk for people of age
years, who have K11_HYPERTROPHY_TONGUE_PAPILLAE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.14% | 0.29% |
| 5 | 0.731% | 1.595% |
| 10 | 1.941% | 4.474% |
| 15 | 3.717% | 8.043% |
| 20 | 6.267% | 13.1% |
Relationships between endpoints
↥Index endpoint: K11_HYPERTROPHY_TONGUE_PAPILLAE – Hypertrophy of tongue papillae
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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