autoimmune thyroid disease: Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
816 |
4. Check minimum number of eventsNone |
816 |
5. Include endpointsNone |
816 |
6. Filter based on genotype QC (FinnGen only) |
754 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E06
- Name in latin
- Thyreoiditis autoimmunis
Similar endpoints
↥List of similar endpoints to
Autoimmune thyroiditis
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5469 | 4605 | 837 |
| Only index persons | 5134 | 4357 | 777 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.02 |
| Only index persons | 0.14 | 0.16 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 38.53 | 38.87 | 36.49 |
| Only index persons | 38.30 | 38.64 | 36.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 754 | 651 | 103 |
| Unadjusted period prevalence (%) | 0.21 | 0.23 | 0.05 |
| Median age at first event (years) | 44.81 | 43.96 | 50.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 771
- Matched controls
- 7710
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
286.0
307.7
605
97
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
267.8
307.7
343
23
E06.3
ICD-10 Finland
Autoimmune thyroiditis
4503599627370496.0
307.7
723
*
104
Kela drug reimbursment
Thyroid insufficiency
1465.2
230.4
213
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
203.4
186
*
H03BB01
ATC
carbimazole; oral
370.0
152.6
149
5
E03
ICD-10 Finland
Other hypothyroidism
439.9
149.6
145
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
1320.3
119.1
113
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
290.0
101.4
101
*
T86
ICPC
Hypothyroidism/myxoedema
146.6
97.7
102
8
E03.89
ICD-10 Finland
Other specified hypothyroidism
186.7
95.6
98
6
BAA60
NOMESCO Finland
Total thyroidectomy
+∞
73.1
69
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
27.5
71.1
49
19
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
19.3
61.7
49
27
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
139.4
60.9
64
5
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
55.9
53
*
2452A
ICD-9 Finland
Thyroiditis, Chronic lymphocytic thyroiditis
+∞
53.8
51
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.0
43.6
81
147
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
116.5
41.2
44
*
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
86.6
37.2
41
5
E06.9
ICD-10 Finland
Thyroiditis, unspecified
114.8
30.9
33
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.1
28.1
62
131
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.1
25.5
45
77
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
25.1
24
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
25.1
24
*
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
37.6
23.1
29
8
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
20.9
20
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
215.6
20.7
21
*
A10AE05
ATC
insulin detemir; parenteral
4.0
19.0
55
144
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
6.5
18.9
31
49
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
19.3
18.8
28
15
H02AB06
ATC
prednisolone; systemic
2.0
18.6
380
2550
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
30.9
18.4
24
8
A10AB04
ATC
insulin lispro; parenteral
4.8
18.4
42
91
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.5
18.2
64
192
E03.8
ICD-10 Finland
Other specified hypothyroidism
+∞
17.8
17
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
5.8
16.9
31
55
H04AA01
ATC
glucagon; nasal, parenteral
5.2
16.8
35
70
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
16.7
16
*
T85
ICPC
Hyperthyroidism/thyrotoxicosis
48.6
16.1
19
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
61.3
15.8
18
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.1
15.8
44
112
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
15.7
15
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
+∞
15.7
15
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
15.4
336
2262
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
15.4
226
1336
A10AB05
ATC
insulin aspart; parenteral
3.1
15.2
67
231
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
14.6
14
*
A10AB01
ATC
insulin (human); parenteral
4.2
14.4
39
97
C07AB07
ATC
bisoprolol; oral
1.8
14.3
308
2054
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
12.3
14.2
25
21
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
5.6
14.1
27
50
T89
ICPC
Diabetes insulin dependent
3.5
13.6
47
139
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
76.5
13.6
15
*
EP1AE, ,
SPAT
4.2
13.6
36
88
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
13.2
160
879
C07AA05
ATC
propranolol; systemic
1.9
12.9
193
1138
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.3
12.6
25
48
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
12.5
12
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
12.5
247
1590
A10AA01, ,
ATC
4.6
12.0
28
62
BA1AE, ,
SPAT
9.1
11.8
24
27
A10AA02, ,
ATC
4.5
11.8
29
67
A02BC02
ATC
pantoprazole; systemic
1.7
11.5
512
4102
A10AC01
ATC
insulin (human); parenteral
2.7
11.0
63
250
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
4.6
11.0
26
58
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
5.1
10.6
22
44
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
+∞
10.4
10
*
E06.5
ICD-10 Finland
Other chronic thyroiditis
+∞
10.4
10
*
H02AB09
ATC
hydrocortisone; systemic
4.5
10.3
25
57
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
10.2
178
1095
R53
ICD-10 Finland
Malaise and fatigue
1.7
10.0
208
1346
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
9.8
260
1796
B03BA03
ATC
hydroxocobalamin; parenteral
3.2
9.8
39
127
R00.2
ICD-10 Finland
Palpitations
2.2
9.6
82
392
K90.0
ICD-10 Finland
Coeliac disease
3.5
9.5
33
98
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
9.4
9
*
177
Kela drug reimbursment
Insulin glargine 300 U / ml
4.8
9.3
21
45
A02BC03
ATC
lansoprazole; oral
1.7
9.1
206
1359
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
8.4
9.1
19
23
H3600, E103,
ICD-10 Finland
8.4
9.1
19
23
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
11.6
9.1
16
14
ZYC01
NOMESCO Finland
Remote contact by phone
2.4
9.0
60
257
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.0
8.9
112
618
J01FF01
ATC
clindamycin; systemic
1.7
8.7
199
1315
R07.0
ICD-10 Finland
Pain in throat
2.2
8.7
78
380
M25.5
ICD-10 Finland
Pain in joint
1.6
8.7
280
2019
A10AE04
ATC
insulin glargine; parenteral
2.3
8.6
64
288
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
9.1
8.6
17
19
106
Kela drug reimbursment
Hypoparathyroidism
+∞
8.3
8
*
R06.0
ICD-10 Finland
Dyspnoea
1.7
8.3
193
1280
N03AX12
ATC
[U] gabapentin; oral
1.8
7.5
122
731
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
7.5
131
802
2504
FHL
Unilateral resection or enucleation
80.8
7.4
8
*
R51.80
ICD-10 Finland
Headache
1.7
7.4
150
956
E03.82
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
7.3
7
*
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
+∞
7.3
7
*
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
7.3
7
*
E06.0
ICD-10 Finland
Acute thyroiditis
+∞
7.3
7
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
7.3
154
993
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.5
7.2
43
175
UJF32
NOMESCO Finland
Coloscopy
1.7
7.2
165
1087
SXA20
NOMESCO Finland
Local application of medicine to mouth
2.2
7.1
63
305
J01MA02
ATC
ciprofloxacin; systemic
1.5
7.1
248
1807
M54.5
ICD-10 Finland
Low back pain
1.5
7.0
292
2206
Z01.7
ICD-10 Finland
Laboratory examination
1.7
6.9
140
890
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.9
298
2268
J01AA02
ATC
doxycycline; systemic
1.6
6.9
564
4899
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
6.8
183
1252
R03AC02
ATC
salbutamol; inhalant
1.5
6.8
435
3583
XFP96
NOMESCO Finland
Other intraoperative electrophysiological investigation in arhythmia or disturbance of impulse propagation
4.3
6.8
17
40
SPAT1097
SPAT
Recording of ECG
1.9
6.8
87
483
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
6.7
223
1602
XKD00
NOMESCO Finland
Uroflowmetry
2.2
6.6
54
254
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
6.4
150
989
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
70.4
6.4
7
*
TEA00
NOMESCO Finland
Biopsy of lip
7.5
6.4
14
19
A10AB06
ATC
insulin glulisine; parenteral
6.6
6.4
15
23
H36.00
ICD-10 Finland
Diabetic background retinopathy
6.6
6.4
15
23
K29.4
ICD-10 Finland
Chronic atrophic gastritis
5.2
6.3
18
35
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
11.1
6.3
11
10
E83.51
ICD-10 Finland
Hypocalcemia
11.1
6.3
11
10
XQ845
NOMESCO Finland
Dermatoscopy
3.9
6.3
18
47
2448A
ICD-9 Finland
Acquired hypothyroidism, Other specified acquired hypothyroidism[HYPOTHYREOSIS POST THYREOIDITIDEM]
+∞
6.3
6
*
E03.3
ICD-10 Finland
Postinfectious hypothyroidism
+∞
6.3
6
*
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
+∞
6.3
6
*
FP1B5, ,
SPAT
3.1
6.2
25
82
A07AA02
ATC
nystatin; oral
2.4
6.2
43
188
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
3.5
6.2
21
62
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
4.2
6.1
16
39
ZXH06, ,
SPAT
2.3
6.1
44
196
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.0
6.1
66
346
N06AX21
ATC
duloxetine; oral
1.8
6.1
99
592
XCK10
NOMESCO Finland
Photography of fundus of eye
2.1
6.1
59
297
ZYC06
NOMESCO Finland
Real-time text-based remote transaction
10.1
6.0
11
11
E0000UV, ,
ATC
1.5
6.0
318
2502
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
314
242
21.20
307.65
5.3
1.4
4.74
4.54
pmol/l
1.07
290
214
183
95
24.95
243.18
2.5
1.2
3.68
1.65
iu/l
2.74
92
23
309
415
11.76
235.30
1.6
1.2
307.60
72.65
u/ml
14.90
181
136
747
5446
12.94
54.25
13.5
2.8
15.48
14.25
pmol/l
33.62
730
5047
38
32
12.44
37.91
3.2
1.2
80.09
42.66
u/ml
—
16
5
166
601
3.25
35.75
2.5
1.9
397.37
389.49
nmol/l
0.20
156
560
457
2974
2.32
28.04
7.4
6.5
1.22
1.22
mmol/l
0.17
406
2595
328
1894
2.27
26.37
1.5
1.3
2.87
1.66
u/ml
0.49
104
503
751
6362
7.96
25.83
15.4
3.8
2.13
1.81
mu/l
4.08
735
5978
633
4979
2.52
21.80
5.4
4.2
10.91
10.84
mm/h
0.05
604
4678
506
3667
2.11
20.80
5.0
4.6
6.74
6.41
mmol/l
2.25
477
3390
396
2646
2.02
20.13
6.5
5.9
1.22
1.22
mmol/l
0.11
369
2459
274
1619
2.07
19.44
1.6
1.5
2.02
2.24
g/l
1.95
170
1011
625
4991
2.33
19.05
8.7
7.2
73.02
76.02
u/l
1.63
597
4737
294
1794
2.03
19.01
2.3
2.1
141.09
191.94
u/l
0.69
285
1716
392
2662
1.96
18.49
4.9
4.5
36.63
36.41
g/l
0.38
368
2519
338
2191
1.97
18.19
2.9
3.2
2.34
2.36
mmol/l
2.81
311
2006
520
3910
2.01
17.98
9.6
9.0
3.75
3.98
e9/l
1.50
460
3393
85
314
2.92
17.11
1.4
1.2
1.43
2.39
u/ml
0.24
12
21
302
1971
1.87
15.22
2.6
2.4
56.10
61.31
u/l
0.79
279
1830
452
3362
1.83
14.75
5.9
5.6
9.55
10.52
umol/l
2.05
431
3206
240
1490
1.89
13.89
1.4
1.3
16.30
28.93
iu/ml
3.00
66
433
223
1366
1.89
13.38
1.4
1.3
2.60
9.83
u/ml
3.67
91
552
64
232
2.92
13.30
1.6
1.2
6.33
43.16
u/ml
—
6
15
738
6680
3.45
12.23
17.7
13.9
3.92
3.92
mmol/l
0.19
730
6518
737
6669
3.38
12.15
17.6
13.9
139.50
139.63
mmol/l
0.82
729
6530
559
4571
1.81
11.96
4.9
4.3
3836.27
2342.55
e6/l
0.15
11
51
296
2036
1.74
11.79
3.8
3.3
6.92
7.58
mmol/l
1.83
270
1762
416
3145
1.70
11.67
3.0
2.5
75.56
76.48
nmol/l
0.29
383
2914
53
189
2.94
11.34
1.5
1.2
43.98
41.54
u/ml
0.04
12
21
76
329
2.45
11.14
2.3
2.0
9.06
8.55
iu/ml
0.05
20
79
302
2123
1.69
10.90
3.4
3.2
29.39
29.55
ng/l
0.00
184
1248
476
3778
1.68
10.70
4.2
3.7
0.00
0.02
estimate
1.49
85
739
468
3717
1.66
10.32
4.1
3.7
0.00
0.00
estimate
0.50
84
765
193
1216
1.78
10.20
1.7
1.6
53205581.62
49712520.28
pmol/l
0.02
156
1042
470
3748
1.65
10.10
4.2
3.7
28.62
8.30
estimate
0.49
90
773
735
6752
2.90
9.60
16.7
12.8
18.03
21.65
mg/l
2.87
626
5418
55
220
2.62
9.50
1.7
1.3
6.02
9.93
u/ml
—
9
42
185
1176
1.75
9.40
2.4
2.4
2.42
2.44
mmol/l
0.88
164
1050
38
125
3.15
9.36
1.4
1.2
—
—
—
0
0
54
218
2.59
9.16
1.7
1.3
15.46
2.88
u/ml
—
8
25
256
1788
1.65
9.12
5.0
4.0
5.35
7.77
mg/mmol
1.01
171
1095
156
960
1.78
8.81
3.7
3.0
0.83
0.82
mmol/l
0.67
149
922
54
224
2.52
8.67
3.3
3.3
26.04
25.27
mmol/l
1.00
54
214
366
2821
1.57
8.46
4.2
3.5
0.01
0.04
estimate
0.68
74
643
83
421
2.09
8.34
2.6
4.1
55.30
77.23
ng/l
5.37
71
376
280
2035
1.59
8.32
4.3
3.6
0.00
0.00
estimate
0.80
82
731
237
1659
1.62
8.22
3.8
3.6
1.02
1.02
kg/l
0.08
151
1082
29
90
3.31
7.87
1.3
1.3
—
—
—
0
0
93
506
1.95
7.69
2.8
2.3
12.99
21.38
au/ml
—
10
58
42
164
2.65
7.64
1.5
1.5
310.14
318.45
ug/g
0.09
22
90
86
458
1.99
7.56
1.6
1.3
41.48
34.08
au/ml
—
6
33
245
1775
1.56
7.17
2.0
1.7
—
—
—
0
0
449
3711
1.50
6.97
3.9
3.0
95.63
79.18
ug/l
0.85
421
3514
749
7071
3.08
6.93
20.3
15.6
70.25
69.26
umol/l
0.50
744
6999
208
1464
1.58
6.86
3.2
2.9
655.36
862.31
ng/l
1.00
174
1218
270
2014
1.52
6.86
3.1
3.0
38.84
69.39
e6/l
0.71
209
1470
233
1699
1.53
6.52
2.3
2.2
2.38
2.70
mg/l
1.73
197
1469
116
719
1.72
6.29
4.8
5.6
1.04
1.05
mmol/l
0.27
109
666
51
239
2.21
6.28
5.2
3.6
48.00
45.90
%
0.25
51
234
158
1062
1.61
6.27
2.5
2.6
88.03
96.01
ug/g
0.23
123
826
147
977
1.62
6.10
2.4
2.3
14.39
13.90
umol/l
0.39
130
906
746
7069
2.71
6.06
14.0
10.4
24.61
24.15
u/l
0.28
731
6901
335
2669
1.45
5.91
2.2
1.9
97.11
97.11
pmol/l
0.00
185
1394
217
1590
1.51
5.84
1.9
1.7
0.85
1.06
mg/l
0.91
162
1211
137
908
1.62
5.73
2.4
2.3
2.48
2.39
g/l
1.17
122
844
87
512
1.79
5.64
3.5
4.3
2.35
1.78
mmol/l
0.98
79
441
83
482
1.81
5.62
2.3
2.2
0.23
0.56
e6/l
0.84
77
450
75
422
1.86
5.62
2.6
3.0
68.15
67.69
g/l
0.25
68
396
686
6337
1.75
5.61
14.4
11.9
87.64
87.56
ml/min/173m2
0.03
643
5767
190
1365
1.52
5.58
2.7
2.5
6.12
7.59
e6/l
0.77
169
1229
16
42
3.87
5.56
1.2
1.1
—
—
—
0
0
77
440
1.83
5.49
3.8
3.3
1.23
1.23
mmol/l
0.14
66
380
20
62
3.29
5.48
1.3
1.0
—
—
—
0
0
541
4759
1.46
5.33
3.7
3.0
39.01
38.64
u/l
0.04
508
4552
207
1536
1.48
5.15
2.7
2.4
299.83
316.17
umol/l
1.81
175
1381
296
2352
1.42
5.10
3.8
3.0
30.43
28.59
u/l
0.35
281
2237
228
1730
1.45
5.04
3.0
2.9
0.23
0.39
e6/l
1.07
166
1195
660
6075
1.60
4.99
7.1
5.2
39.89
37.79
mmol/mol
5.99
637
5763
123
823
1.59
4.92
2.5
2.4
24.76
23.45
%
0.54
107
767
55
293
1.94
4.87
3.0
3.3
1.02
1.02
ratio
0.02
48
272
46
231
2.05
4.80
1.6
1.3
14.55
10.93
u/l
0.65
35
182
111
730
1.61
4.77
6.9
6.9
104.27
104.49
mmol/l
0.17
111
730
150
1062
1.51
4.66
2.7
2.6
0.74
0.95
e6/l
0.60
77
502
19
65
2.97
4.47
1.3
1.2
—
—
—
0
0
87
552
1.65
4.32
1.5
1.3
27.94
24.58
iu/l
0.39
70
475
20
72
2.83
4.31
1.3
1.2
—
—
—
0
0
122
842
1.53
4.25
1.7
1.6
1192.64
1210.07
nmol/l
0.09
100
643
18
63
2.90
4.08
1.3
1.2
—
—
—
0
0
18
63
2.90
4.08
1.3
1.2
—
—
—
0
0
29
133
2.23
3.84
3.2
2.5
—
—
—
0
0
16
55
2.95
3.75
1.3
1.2
0.53
0.60
ratio
0.82
11
31
17
61
2.83
3.71
1.3
1.2
—
—
—
0
0
17
61
2.83
3.71
1.3
1.2
—
—
—
0
0
34
170
2.05
3.64
1.6
1.5
3.71
6.78
e6/l
0.69
28
124
16
56
2.90
3.64
1.4
1.0
0.90
1.12
u/l
—
9
21
34
173
2.01
3.49
1.7
1.5
71.21
142.22
e6/l
0.48
29
134
128
929
1.45
3.48
1.9
1.8
—
—
—
0
0
254
2069
1.34
3.47
3.8
3.0
0.04
0.01
estimate
0.30
75
632
82
545
1.56
3.39
1.3
1.3
177.55
154.69
u/ml
0.13
77
507
51
300
1.75
3.37
1.4
1.4
—
—
—
0
0
15
53
2.87
3.37
1.6
1.9
18.25
24.12
nmol/l
1.78
15
53
41
226
1.86
3.35
1.3
1.2
2.78
4.83
—
6
35
217
1735
1.35
3.34
1.7
1.6
20.10
21.15
nmol/l
0.52
196
1485
379
3287
1.30
3.25
2.8
2.6
—
—
estimate
—
0
0
130
960
1.43
3.22
2.6
2.7
4.32
3.74
e6/l
0.18
59
402
104
738
1.47
3.18
3.1
2.6
5.47
5.95
umol/l
0.26
80
640
207
1660
1.34
3.10
2.3
2.1
—
—
—
0
0
56
347
1.66
3.09
3.4
2.8
99.45
140.74
ng/l
0.78
49
316
630
5889
1.38
3.02
19.0
15.8
13.39
13.42
%
0.26
623
5823
22
101
2.21
2.95
2.1
2.7
100.08
82.67
ug/min
0.10
16
59
63
409
1.59
2.90
2.0
1.7
—
—
—
0
0
760
7423
2.67
2.86
26.9
19.6
268.74
261.06
e9/l
3.19
753
7302
87
609
1.48
2.86
3.9
4.2
216.91
253.39
u/l
1.59
82
576
17
71
2.43
2.81
1.1
1.2
0.15
0.18
nmol/l
0.82
12
50
760
7426
2.64
2.80
26.8
19.5
90.37
90.59
fl
0.78
755
7370
760
7428
2.62
2.76
26.8
19.5
4.47
4.46
e12/l
0.37
751
7284
760
7428
2.62
2.76
27.2
19.9
40.27
40.00
%
1.31
755
7369
655
6192
1.38
2.67
4.6
3.8
1.22
1.21
mmol/l
0.19
617
5807
760
7433
2.57
2.66
27.0
19.7
134.05
133.65
g/l
0.45
755
7376
326
2828
1.26
2.61
2.0
1.8
1.32
1.32
mmol/l
0.00
274
2457
8
20
4.03
2.57
1.3
1.0
—
—
—
0
0
22
108
2.07
2.54
2.3
2.6
7.52
7.56
pmol/l
0.01
22
108
58
383
1.56
2.51
1.5
1.4
373.24
285.50
mu/l
0.47
50
342
68
469
1.49
2.42
1.1
1.0
—
—
—
0
0
47
298
1.61
2.42
1.9
1.8
—
—
—
0
0
687
6577
1.41
2.31
5.6
4.5
4.77
4.77
mmol/l
0.08
658
6241
32
186
1.75
2.28
1.1
1.1
4.85
1.32
u/ml
0.68
15
92
685
6558
1.40
2.27
5.4
4.4
1.51
1.54
mmol/l
1.29
651
6193
41
258
1.62
2.20
1.7
1.3
—
—
—
0
0
16
74
2.19
2.16
1.7
2.0
—
—
—
0
0
82
601
1.41
2.15
7.4
8.4
1.41
1.04
mmol/l
0.30
64
498
17
82
2.10
2.08
1.2
1.1
—
—
—
0
0
692
6653
1.39
2.08
6.3
5.0
2.83
2.80
mmol/l
0.32
657
6288
88
660
1.38
2.03
2.0
2.2
37.79
36.74
u/l
0.05
71
545
37
232
1.62
2.03
1.8
1.5
0.24
0.35
iu/ml
—
5
39
33
201
1.67
2.02
2.8
2.5
3.21
3.70
g/l
1.34
33
192
26
148
1.78
2.00
1.1
1.3
—
—
—
0
0
88
662
1.37
1.99
2.0
1.8
—
—
—
0
0
69
498
1.42
1.99
3.7
2.4
73.71
73.79
ml/min/173m2
0.01
31
201
141
1143
1.29
1.91
4.2
3.2
100.16
346.71
ng/l
1.49
82
739
31
189
1.67
1.90
1.1
1.3
—
—
—
0
0
91
694
1.35
1.90
1.8
1.7
—
—
—
0
0
36
230
1.59
1.85
2.3
2.3
98.28
95.55
%
0.55
36
224
5
12
4.19
1.82
1.2
1.2
—
—
—
0
0
24
138
1.76
1.81
1.2
1.2
8.78
3.02
u/ml
—
9
47
9
36
2.52
1.74
3.8
3.5
773.56
515.56
u/ml
—
9
36
7
24
2.93
1.72
1.4
1.5
—
—
—
0
0
29
179
1.64
1.72
1.6
1.4
0.40
0.44
nmol/l
0.13
19
152
5
13
3.86
1.71
1.0
1.1
—
—
—
0
0
661
6350
1.29
1.68
5.2
4.4
5.85
5.73
mmol/l
1.23
625
5917
10
40
2.52
1.67
2.0
2.0
—
—
—
0
0
20
112
1.81
1.66
1.5
1.3
—
—
—
0
0
11
49
2.26
1.64
1.9
2.2
584.82
505.72
e6/l
0.20
11
39
13
63
2.08
1.60
1.4
1.5
—
—
—
0
0
11
50
2.22
1.57
1.9
2.2
262.82
191.80
e6/l
0.68
11
44
8
33
2.44
1.54
1.3
1.2
137.51
189.62
iu/ml
—
8
33
7
27
2.61
1.51
1.1
1.1
—
—
—
0
0
9
38
2.38
1.46
1.6
1.8
—
86.00
%
—
0
6
21
125
1.70
1.45
1.2
1.0
1.63
2.07
eliau/ml
—
6
63
30
197
1.54
1.42
1.1
1.1
1.84
4.88
u/ml
1.47
14
116
11
53
2.09
1.39
2.5
2.5
1.22
1.19
mmol/l
1.55
11
53
12
60
2.02
1.38
1.2
1.5
—
—
—
0
0
534
5053
1.18
1.38
3.7
3.5
—
—
—
0
0
72
560
1.32
1.36
2.8
2.3
4575.83
7549.29
u/l
0.35
29
246
34
232
1.49
1.36
1.1
1.1
4.27
2.65
u/ml
0.26
18
127
0
39
0.00
1.34
0.0
1.1
—
—
—
0
0
11
54
2.05
1.33
2.5
2.5
4.00
3.97
mmol/l
0.09
11
54
11
54
2.05
1.33
2.5
2.5
106.55
106.78
mmol/l
0.08
11
54
63
483
1.33
1.32
1.3
1.5
—
—
—
0
0
23
146
1.59
1.27
3.5
3.5
1.14
2.21
ratio
1.27
16
76
74
586
1.29
1.24
3.0
2.7
—
—
—
0
0
22
139
1.60
1.24
1.2
1.2
8.91
4.00
u/ml
0.32
11
48
10
49
2.05
1.22
1.7
1.3
—
—
—
0
0
10
49
2.05
1.22
1.7
1.3
—
—
—
0
0
10
49
2.05
1.22
1.7
1.3
—
—
—
0
0
25
165
1.53
1.19
4.6
3.8
18.05
36.82
mg/l
5.88
19
143
25
165
1.53
1.19
4.6
3.8
18.16
47.11
mg/l
1.02
19
141
6
26
2.32
1.19
1.2
1.6
—
—
—
0
0
74
917
0.79
1.18
2.0
1.8
3.68
3.30
ratio
1.60
56
688
11
57
1.94
1.17
1.5
1.6
—
—
—
0
0
5
20
2.51
1.15
1.2
1.2
159.22
142.55
pmol/l
—
5
20
5
20
2.51
1.15
1.0
1.2
—
—
—
0
0
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
41
301
1.38
1.15
1.6
1.7
32.04
10.15
u/ml
—
5
70
21
317
0.65
1.13
1.0
1.1
0.91
0.87
g/l
0.30
21
317
11
58
1.91
1.12
1.0
1.0
—
—
—
0
0
7
31
2.27
1.10
1.4
1.5
—
—
—
0
0
5
21
2.39
1.09
1.0
1.1
—
—
—
0
0
5
21
2.39
1.09
1.0
1.2
—
—
—
0
0
5
21
2.39
1.09
1.0
1.2
—
—
—
0
0
5
21
2.39
1.09
1.0
1.1
—
—
—
0
0
5
21
2.39
1.09
1.0
1.1
—
—
—
0
0
8
41
1.96
1.09
1.3
2.3
96.38
104.95
%
—
8
41
11
59
1.88
1.07
1.3
1.3
—
—
—
0
0
11
59
1.88
1.07
2.9
2.4
33.09
32.27
pg
0.33
11
59
11
60
1.85
1.03
1.3
1.3
—
—
—
0
0
21
310
0.67
1.03
1.0
1.1
1.51
1.57
g/l
0.61
21
310
7
34
2.07
1.03
1.1
1.1
—
—
—
0
0
12
68
1.78
1.01
1.3
1.4
—
—
—
0
0
12
68
1.78
1.01
1.3
1.4
—
—
—
0
0
12
68
1.78
1.01
1.3
1.4
—
—
—
0
0
19
123
1.56
1.00
1.1
1.1
—
—
—
0
0
18
115
1.58
1.00
1.6
1.3
—
—
—
0
0
23
330
0.69
0.98
1.9
1.8
—
—
—
0
0
7
36
1.95
0.97
1.0
1.1
—
—
—
0
0
9
51
1.77
0.94
1.2
1.5
—
—
—
0
0
28
202
1.40
0.90
1.9
1.9
—
—
—
0
0
6
29
2.08
0.89
1.0
1.3
—
—
—
0
0
10
56
1.80
0.88
1.2
1.2
125.40
110.96
pmol/l
—
10
56
6
33
1.82
0.79
1.7
1.5
60.47
80.98
ng/l
—
6
33
22
157
1.41
0.77
1.2
1.1
29.37
12.67
au/ml
—
7
49
26
192
1.37
0.76
1.9
1.8
—
—
—
0
0
9
53
1.71
0.75
1.2
1.4
—
—
—
0
0
20
142
1.42
0.73
2.1
2.0
126.33
129.92
g/l
0.26
12
111
60
715
0.83
0.72
1.6
1.7
3.88
3.43
mmol/l
2.18
44
488
22
160
1.39
0.71
1.6
1.3
—
—
—
0
0
7
41
1.71
0.70
1.0
1.1
—
—
—
0
0
7
42
1.67
0.68
1.3
1.0
9.29
8.00
mm/h
—
7
42
18
128
1.42
0.66
1.2
1.8
—
—
—
0
0
25
190
1.33
0.63
2.5
2.2
6.84
6.06
umol/l
0.14
17
141
35
280
1.26
0.62
3.3
4.2
1.22
1.45
mmol/l
0.15
28
202
20
148
1.36
0.60
1.7
1.3
—
—
—
0
0
10
64
1.57
0.58
1.2
1.4
—
—
—
0
0
65
560
1.18
0.57
4.1
4.2
39.00
17.18
ug/l
0.35
50
449
10
65
1.55
0.55
1.2
1.4
—
—
—
0
0
10
65
1.55
0.55
1.2
1.4
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
38
1.58
0.54
1.2
1.2
—
—
—
0
0
16
117
1.38
0.52
1.0
1.1
—
—
—
0
0
16
117
1.38
0.52
1.1
1.2
115.69
119.42
%
0.16
16
111
13
93
1.40
0.48
1.5
1.5
—
—
—
0
0
18
137
1.32
0.47
2.9
3.4
25.50
25.58
mg/l
—
10
89
15
111
1.36
0.47
1.5
1.7
—
—
—
0
0
15
111
1.36
0.47
1.8
2.0
13.13
13.14
%
0.01
15
111
38
320
1.20
0.45
1.9
1.5
0.23
0.32
mg/l
—
5
124
32
265
1.22
0.45
1.4
1.3
—
—
—
0
0
45
386
1.18
0.44
1.4
1.3
254.19
246.79
miu/ml
0.04
27
206
13
95
1.37
0.44
2.0
1.2
—
—
—
0
0
20
157
1.28
0.43
1.4
1.4
283.92
208.44
u/ml
0.63
15
89
5
33
1.52
0.41
1.6
1.1
56.84
57.53
u/ml
—
5
33
15
114
1.32
0.41
1.0
1.3
—
—
—
0
0
15
114
1.32
0.41
1.0
1.3
—
—
—
0
0
60
532
1.14
0.40
1.4
1.4
—
—
—
0
0
5
35
1.43
0.39
1.0
1.2
—
54.00
—
0
5
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
26
311
0.83
0.37
1.7
1.9
—
—
—
0
0
22
180
1.23
0.36
1.6
1.4
—
—
—
0
0
66
594
1.12
0.36
6.5
5.2
1.71
2.22
ug/l
0.61
60
527
5
77
0.65
0.36
1.6
1.6
—
—
—
0
0
23
190
1.22
0.35
1.9
2.1
0.62
0.57
g/l
0.04
18
172
6
44
1.37
0.34
1.0
1.1
—
—
—
0
0
66
726
0.90
0.32
4.9
4.1
33.32
32.37
%
0.28
47
491
49
437
1.13
0.32
1.4
1.5
1.09
1.21
ratio
0.38
23
273
49
437
1.13
0.32
1.4
1.5
1.02
1.18
ratio
0.70
23
273
49
437
1.13
0.32
1.4
1.5
0.90
0.96
ratio
0.42
23
273
48
431
1.12
0.29
1.4
1.5
—
—
—
0
0
8
64
1.25
0.27
4.5
4.0
—
—
—
0
0
27
310
0.87
0.26
1.7
1.7
—
—
—
0
0
12
95
1.27
0.26
1.1
1.1
90.92
95.01
%
0.21
12
89
9
74
1.22
0.25
1.3
1.3
—
—
—
0
0
5
38
1.32
0.23
1.8
1.5
—
—
—
0
0
52
478
1.09
0.22
5.1
4.4
20.39
21.36
%
0.17
27
227
24
210
1.15
0.22
1.3
1.2
—
—
—
0
0
5
42
1.19
0.21
1.2
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
10.1
—
5.85
—
0
10
0
10
0.00
0.21
0.0
1.0
—
12.45
—
0
10
8
104
0.77
0.21
3.5
3.7
496.48
1110.94
u/ml
—
8
96
24
211
1.14
0.21
1.3
1.2
—
—
—
0
0
85
801
1.07
0.20
2.0
1.9
—
—
—
0
0
14
117
1.20
0.20
1.9
1.4
—
—
—
0
0
10
80
1.25
0.20
3.8
2.2
3.01
9.53
u/ml
—
10
80
25
281
0.89
0.19
1.6
1.5
52.25
56.95
ug/l
0.46
25
281
18
204
0.88
0.16
1.7
1.6
—
—
—
0
0
50
467
1.08
0.16
1.4
1.6
58.13
61.76
ug/l
0.26
39
392
19
170
1.12
0.13
1.6
1.4
—
—
—
0
0
5
45
1.11
0.10
1.4
1.6
0.72
0.47
e9/l
—
5
45
5
46
1.09
0.09
1.4
1.3
83.20
71.59
umol/l
—
5
46
16
145
1.11
0.09
1.2
1.3
—
—
—
0
0
178
1814
0.98
0.09
1.5
1.5
—
—
—
0
0
6
54
1.11
0.09
1.2
1.1
—
—
—
0
0
87
845
1.03
0.08
1.5
1.7
1.32
1.37
%
0.39
79
761
34
357
0.95
0.07
4.1
3.1
0.65
0.79
ug/l
0.66
24
220
8
78
1.03
0.07
1.3
1.4
—
—
—
0
0
9
85
1.06
0.07
2.0
1.3
—
—
—
0
0
39
374
1.05
0.06
1.4
1.4
—
—
—
0
0
9
100
0.90
0.06
1.7
1.5
—
—
—
0
0
100
980
1.02
0.05
2.2
2.1
—
—
—
0
0
14
151
0.93
0.05
1.6
1.5
—
—
—
0
0
39
377
1.04
0.04
1.5
1.6
—
—
—
0
0
15
160
0.94
0.04
2.2
3.1
0.80
2.52
index
—
5
76
78
795
0.98
0.04
1.5
1.6
887.41
1013.16
mu/l
0.77
64
663
10
92
1.09
0.03
1.5
1.2
—
—
—
0
0
131
1297
1.01
0.02
2.2
2.2
—
—
—
0
0
39
399
0.98
0.02
1.5
1.5
—
—
—
0
0
64
631
1.02
0.02
7.5
5.4
—
—
—
0
0
33
338
0.98
0.01
1.7
1.8
4.37
4.72
mg/l
0.06
22
246
12
127
0.94
0.01
1.1
1.8
—
—
—
0
0
140
1410
0.99
0.01
2.3
2.4
—
—
—
0
0
45
444
1.01
0.00
1.4
1.4
—
—
—
0
0
15
147
1.02
0.00
1.9
1.7
6482.78
9690.12
e6/l
—
9
102
22
217
1.01
0.00
1.4
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
2.05
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
4.6
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
8
87
0.92
-0.00
1.1
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.3
—
3.90
—
0
8
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
13.83
—
0
6
7
74
0.95
-0.00
1.1
3.9
30.67
66.68
u/ml
—
7
74
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.7
—
1.13
—
0
8
0
9
0.00
-0.00
0.0
10.9
—
10.31
—
0
9
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITAUTOIM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITAUTOIM | 1.029 [0.88, 1.2] | 0.713 |
| Birth year | 0.996 [0.99, 1.0] | 0.367 |
During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 3629 females with E4_THYROIDITAUTOIM died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYROIDITAUTOIM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | No data |
| 5 | 0.497% | No data |
| 10 | 1.444% | No data |
| 15 | 2.964% | No data |
| 20 | 5.351% | No data |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITAUTOIM – Autoimmune thyroiditis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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