No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditions
|
816 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
165 |
4. Check minimum number of eventsNone |
165 |
5. Include endpointsNone |
165 |
6. Filter based on genotype QC (FinnGen only) |
154 |
Control definitions (FinnGen only)
- Control conditions
- not E4_THYROIDITAUTOIM
Extra metadata
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Hypothyroidism, autoimmune, DX-based
based on the number of shared cases.
Similar with more cases:
- Autoimmune thyroiditis
- Thyroiditis
- Thyroiditis, ILD-related definition
- Disorders of thyroid, IBD co-morbidities
- Autoimmune diseases related-to ILD
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1013 | 858 | 154 |
| Only index persons | 972 | 826 | 146 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.00 |
| Only index persons | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 25.77 | 27.49 | 15.90 |
| Only index persons | 26.47 | 28.23 | 16.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 154 | 140 | 14 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.01 |
| Median age at first event (years) | 41.45 | 41.35 | 42.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 158
- Matched controls
- 1580
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.3
ICD-10 Finland
Autoimmune thyroiditis
8792.4
207.2
153
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
10755.2
199.2
157
20
H03AA01
ATC
levothyroxine sodium; systemic
188.3
98.5
154
268
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
14.6
67.2
95
148
104
Kela drug reimbursment
Thyroid insufficiency
11.8
45.4
57
72
E03.89
ICD-10 Finland
Other specified hypothyroidism
16.4
39.7
37
29
T86
ICPC
Hypothyroidism/myxoedema
9.6
22.5
29
36
E03
ICD-10 Finland
Other hypothyroidism
7.0
21.1
37
66
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
9.4
19.3
25
31
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.7
15.0
26
45
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
16.7
11.6
18
12
XCK10
NOMESCO Finland
Photography of fundus of eye
5.6
11.1
23
47
A10AB05
ATC
insulin aspart; parenteral
5.4
10.9
23
48
A10AC01
ATC
insulin (human); parenteral
4.9
9.7
23
53
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
10.0
9.3
18
20
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
9.5
9.1
18
21
A10AE05
ATC
insulin detemir; parenteral
7.2
8.8
21
33
A10AB04
ATC
insulin lispro; parenteral
8.7
8.6
18
23
T89
ICPC
Diabetes insulin dependent
7.2
8.5
20
31
A10AE04
ATC
insulin glargine; parenteral
4.4
8.5
23
59
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.1
8.3
42
165
H03BB01
ATC
carbimazole; oral
4.9
8.1
19
43
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.1
8.1
41
161
H04AA01
ATC
glucagon; nasal, parenteral
9.6
7.7
15
17
103
Kela drug reimbursment
Diabetes, insulin-treated
3.0
7.6
41
166
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
10.1
7.5
14
15
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
7.3
55
266
A10AB01
ATC
insulin (human); parenteral
7.4
6.7
15
22
H3600, E103,
ICD-10 Finland
15.1
6.5
10
7
E03.8
ICD-10 Finland
Other specified hypothyroidism
72.7
6.5
7
*
2452A
ICD-9 Finland
Thyroiditis, Chronic lymphocytic thyroiditis
+∞
6.3
6
*
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.3
6.2
69
394
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
9.2
6.2
12
14
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
73
114
11.04
49.77
4.8
3.7
4.52
4.76
pmol/l
0.55
66
100
59
158
5.36
21.89
1.7
1.2
343.07
165.86
u/ml
1.79
36
61
30
60
5.94
15.00
2.0
1.9
2.92
6.49
iu/l
0.94
12
24
98
617
2.55
7.45
7.0
6.9
1.21
1.22
mmol/l
0.26
89
540
118
825
2.70
6.99
7.7
10.2
3.62
3.98
e9/l
1.19
108
733
85
529
2.31
6.26
5.4
4.8
36.50
36.82
g/l
0.23
80
511
22
71
3.44
5.88
4.1
2.0
5.37
3.08
iu/ml
—
6
16
19
59
3.52
5.37
2.6
1.6
0.20
0.23
g/l
0.85
19
59
56
313
2.22
5.13
1.6
1.4
4.92
6.77
u/ml
0.27
19
139
71
446
2.07
4.75
1.9
1.4
4.23
1.29
u/ml
0.47
24
126
58
340
2.12
4.64
1.6
1.4
16.83
20.53
iu/ml
0.27
18
102
130
1062
2.26
3.84
6.1
4.1
10.54
9.72
mm/h
0.40
125
989
70
468
1.89
3.69
2.5
3.1
2.35
2.36
mmol/l
0.45
62
430
47
278
1.98
3.54
2.5
3.4
289.46
822.76
ng/l
4.28
42
231
79
558
1.83
3.44
6.9
6.6
1.21
1.22
mmol/l
0.41
73
522
8
14
5.95
3.38
1.0
1.6
—
—
—
0
0
90
664
1.83
3.38
3.2
2.6
76.74
75.27
nmol/l
0.19
79
609
17
66
2.77
3.34
1.1
1.6
14.09
10.42
u/l
0.25
12
50
54
343
1.87
3.27
3.5
3.5
1.02
1.02
kg/l
0.01
34
204
102
792
1.81
3.13
3.9
3.6
78.27
10.02
estimate
0.40
15
162
102
796
1.79
3.04
4.9
4.6
6.97
6.25
mmol/l
2.41
94
726
54
351
1.82
3.00
7.1
3.7
1.98
10.74
mg/mmol
2.82
41
198
62
422
1.77
2.95
3.7
3.6
0.00
0.00
estimate
-0.00
12
158
100
786
1.74
2.81
3.9
3.6
0.00
0.00
estimate
-0.00
14
160
49
315
1.81
2.80
2.8
2.9
291.09
313.17
umol/l
0.95
44
289
101
797
1.74
2.79
3.9
3.7
0.00
0.00
estimate
-0.00
13
152
25
130
2.10
2.64
1.4
1.5
20.06
22.19
iu/l
0.13
18
110
63
443
1.70
2.61
4.1
3.0
—
—
—
0
0
19
89
2.29
2.57
2.5
2.5
0.19
0.20
e6/l
0.03
19
83
6
11
5.62
2.56
1.0
1.4
—
—
—
0
0
9
27
3.47
2.43
2.4
2.5
—
—
—
0
0
37
228
1.81
2.40
1.6
1.6
465.32
34184143.06
pmol/l
0.50
31
196
6
13
4.75
2.29
1.0
1.0
—
—
—
0
0
59
420
1.65
2.28
2.8
3.0
17.14
18.44
ng/l
0.11
38
235
13
54
2.53
2.26
3.0
2.8
25.38
24.17
mmol/l
0.61
13
54
5
9
5.69
2.23
1.0
1.1
—
—
—
0
0
151
1409
2.62
2.06
16.8
12.6
15.63
18.46
mg/l
0.90
132
1109
11
44
2.61
2.06
1.2
1.2
306.20
306.13
ug/g
—
5
23
13
58
2.35
1.97
1.7
1.4
—
—
—
0
0
52
375
1.58
1.85
2.3
2.4
2.68
2.65
mg/l
0.04
42
315
26
156
1.80
1.83
4.9
7.6
104.96
104.47
mmol/l
0.22
26
156
7
23
3.14
1.82
1.0
1.3
—
—
—
0
0
6
18
3.42
1.76
2.8
2.7
129.28
78.56
ug/min
—
6
11
141
1285
1.90
1.74
13.6
11.6
90.22
90.06
ml/min/173m2
0.03
132
1152
33
217
1.66
1.70
2.9
2.8
0.99
0.97
e6/l
0.01
18
111
12
56
2.24
1.66
3.6
3.8
41.27
49.25
%
0.44
12
56
6
20
3.08
1.59
1.8
1.1
—
—
—
0
0
6
20
3.08
1.59
1.0
1.3
—
—
—
0
0
6
20
3.08
1.59
1.0
1.3
—
—
—
0
0
6
20
3.08
1.59
1.0
1.3
—
—
—
0
0
70
559
1.45
1.49
2.2
2.0
101.66
98.78
pmol/l
0.19
43
292
6
22
2.79
1.45
1.0
1.2
—
—
—
0
0
57
443
1.45
1.38
2.5
2.5
48.27
65.49
u/l
1.10
52
420
6
23
2.67
1.38
1.3
1.9
4.15
5.35
pmol/l
—
6
23
152
1448
2.31
1.36
19.7
14.8
67.80
67.58
umol/l
0.05
152
1425
19
114
1.76
1.35
6.7
8.5
0.42
1.21
mmol/l
0.40
13
99
27
179
1.61
1.35
2.2
2.4
2.56
2.39
g/l
0.88
22
164
6
24
2.56
1.31
1.5
1.2
—
—
—
0
0
25
164
1.62
1.30
1.4
1.6
978.63
1119.39
nmol/l
0.43
17
119
5
18
2.83
1.29
1.0
1.3
—
—
—
0
0
50
384
1.44
1.28
1.5
1.6
20.13
21.76
nmol/l
0.39
45
327
72
593
1.39
1.24
3.9
3.3
0.10
0.00
estimate
—
10
136
10
50
2.07
1.19
1.4
3.9
167.40
165.28
%
—
10
50
8
39
2.11
1.17
2.0
2.0
25.32
23.82
mmol/l
—
8
39
33
238
1.49
1.15
2.3
2.5
2.43
2.43
mmol/l
0.03
27
217
83
706
1.37
1.15
2.7
2.7
—
—
estimate
—
0
0
7
30
2.39
1.14
1.0
1.1
—
—
—
0
0
15
89
1.76
1.12
1.6
1.4
—
—
—
0
0
46
356
1.41
1.12
3.4
2.9
0.02
0.30
e6/l
4.90
31
256
46
357
1.41
1.10
2.1
2.2
—
—
—
0
0
28
197
1.51
1.10
2.9
3.1
3.69
4.12
e6/l
0.11
13
90
70
586
1.35
1.05
2.1
1.9
1.19
1.33
mmol/l
0.93
63
511
7
34
2.11
1.04
1.0
1.3
—
—
—
0
0
7
34
2.11
1.04
2.9
2.2
0.62
0.91
nmol/l
—
7
29
5
22
2.31
1.04
1.6
1.1
—
—
—
0
0
5
22
2.31
1.04
1.0
3.5
—
—
—
0
0
12
68
1.83
1.03
1.5
1.5
—
—
—
0
0
25
174
1.52
1.03
1.7
1.7
—
—
—
0
0
19
124
1.61
1.02
1.6
1.7
—
—
—
0
0
42
325
1.40
1.02
1.8
2.0
0.63
1.34
mg/l
1.19
32
239
9
50
1.85
0.98
1.3
1.1
—
9.71
—
0
9
0
31
0.00
0.97
0.0
2.0
—
—
—
0
0
27
194
1.47
0.96
2.3
2.4
12.60
13.75
umol/l
0.43
21
179
6
27
2.27
0.94
1.2
1.1
—
—
—
0
0
12
71
1.75
0.91
2.2
1.5
—
—
—
0
0
23
162
1.49
0.91
2.3
2.4
23.86
22.75
%
0.12
17
152
142
1345
1.55
0.87
6.2
5.0
2.83
2.82
mmol/l
0.04
137
1262
141
1334
1.53
0.87
5.5
4.5
1.51
1.54
mmol/l
0.37
136
1249
6
113
0.51
0.87
3.2
3.1
—
—
—
0
0
134
1259
1.42
0.82
4.6
3.8
1.18
1.19
mmol/l
0.11
126
1169
8
47
1.74
0.82
1.0
1.5
—
—
—
0
0
14
90
1.61
0.81
1.4
1.3
—
—
—
0
0
16
109
1.52
0.74
1.1
1.0
—
—
—
0
0
17
120
1.47
0.68
1.6
1.3
445.32
338.14
u/ml
0.12
17
112
42
346
1.29
0.67
2.5
2.4
—
—
—
0
0
28
218
1.35
0.66
3.5
3.4
56.16
389.74
ng/l
1.14
17
135
18
130
1.43
0.64
1.4
1.6
—
—
—
0
0
16
114
1.45
0.61
1.4
1.6
1.18
1.10
ratio
—
7
76
16
114
1.45
0.61
1.4
1.6
1.18
1.23
ratio
—
7
76
16
114
1.45
0.61
1.4
1.6
0.90
0.94
ratio
—
7
76
17
123
1.43
0.61
2.7
4.9
5.85
5.72
kpa
0.26
17
123
8
53
1.54
0.59
1.1
1.2
—
7.00
—
0
8
19
144
1.36
0.53
3.1
2.4
359.86
7398.39
u/l
—
7
56
6
39
1.56
0.53
1.8
1.9
—
—
—
0
0
6
40
1.52
0.52
1.7
2.0
—
—
—
0
0
15
110
1.40
0.51
1.4
1.6
—
—
—
0
0
38
321
1.24
0.50
2.3
2.3
—
—
—
0
0
46
398
1.22
0.49
1.5
1.6
—
—
—
0
0
15
111
1.39
0.49
1.3
1.5
—
—
—
0
0
5
81
0.60
0.47
1.2
1.5
—
—
—
0
0
8
59
1.37
0.41
1.8
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
107.47
—
0
15
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
51
453
1.19
0.41
2.6
1.7
—
—
—
0
0
8
60
1.35
0.41
6.4
9.3
24.00
24.79
mmol/l
—
8
60
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
5
35
1.44
0.39
1.6
1.3
—
—
—
0
0
108
1023
1.18
0.38
3.3
3.3
39.63
35.05
u/l
0.35
103
983
5
79
0.62
0.36
1.6
5.4
22.84
24.34
mmol/l
—
5
79
6
45
1.35
0.34
1.2
1.4
—
—
—
0
0
6
88
0.67
0.34
8.0
8.9
24.68
25.05
mmol/l
—
6
88
17
138
1.26
0.32
1.7
1.5
—
—
—
0
0
7
53
1.34
0.31
1.3
1.2
—
—
—
0
0
22
191
1.18
0.23
2.3
2.0
—
—
—
0
0
13
107
1.23
0.22
2.8
4.6
4.44
4.75
kpa
0.23
13
107
0
11
0.00
0.21
0.0
1.0
—
1721.91
—
0
11
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
10
0.00
0.21
0.0
1.0
—
144.00
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
6
48
1.26
0.20
1.2
1.4
1.85
3.29
ug/l
—
6
43
16
139
1.17
0.17
7.4
4.8
—
—
—
0
0
8
69
1.17
0.17
2.5
4.0
2.03
1.19
%
—
8
69
6
80
0.74
0.16
1.3
1.9
—
—
—
0
0
8
100
0.79
0.14
1.3
1.3
—
—
—
0
0
48
456
1.08
0.12
2.9
2.9
0.00
0.01
estimate
—
10
134
5
46
1.09
0.09
1.4
1.2
—
—
—
0
0
25
233
1.09
0.09
2.9
2.1
—
—
—
0
0
5
47
1.07
0.09
1.4
1.2
—
—
—
0
0
8
77
1.04
0.07
1.9
1.5
60.97
56.00
ug/l
—
8
77
113
1118
1.04
0.04
3.9
3.8
—
—
—
0
0
130
1309
0.96
0.03
5.3
4.3
6.00
5.63
mmol/l
1.48
123
1204
10
99
1.01
0.00
1.6
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
110.71
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
1.33
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
275.57
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
60
1.00
-0.00
1.5
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
4.55
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
10.76
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
71
0.99
-0.00
4.0
4.7
2.25
1.64
ug/l
—
7
62
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.0
—
20.40
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYTHY_AI_DX and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_HYTHY_AI_DX.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_HYTHY_AI_DX – Hypothyroidism, autoimmune, DX-based
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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