bacterial meningitis: Inflammation of the membranes surrounding the brain and spinal cord due to a bacterial infection.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1484 |
4. Check minimum number of eventsNone |
1484 |
5. Include endpointsNone |
1484 |
6. Filter based on genotype QC (FinnGen only) |
1313 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEUINFL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Bacterial meningitis
based on the number of shared cases.
Similar with more cases:
- Meningitis
- Inflammatory diseases of the central nervous system
- Neurological diseases
- Neurological diseases, wide definition
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13164 | 5855 | 7210 |
| Only index persons | 10528 | 4917 | 5611 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.17 | 0.20 |
| Only index persons | 0.20 | 0.18 | 0.21 |
| Median age at first event (years) | |||
| Whole population | 26.64 | 28.04 | 25.10 |
| Only index persons | 22.93 | 25.96 | 20.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1313 | 691 | 622 |
| Unadjusted period prevalence (%) | 0.26 | 0.25 | 0.29 |
| Median age at first event (years) | 29.09 | 28.16 | 30.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1358
- Matched controls
- 13580
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
3439.8
309.4
287
*
32099
ICD-8 Finland
Meningitis, With no organism specified as cause
+∞
307.7
372
*
32088
ICD-8 Finland
Meningitis, Alia definita
+∞
214.4
200
*
TAB00
NOMESCO Finland
Lumbar puncture
7.7
126.3
192
285
G01*A69.2
ICD-10 Finland
Meningitis (in) Lyme disease
+∞
122.8
116
*
32000
ICD-8 Finland
Meningitis, H. influenzae
+∞
118.5
112
*
G00.1
ICD-10 Finland
Pneumococcal meningitis
+∞
101.3
96
*
A87.9
ICD-10 Finland
Viral meningitis, unspecified
26.6
88.0
61
24
G03.9
ICD-10 Finland
Meningitis, unspecified
+∞
81.1
77
*
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
20.7
62.8
48
24
AAF00
NOMESCO Finland
Ventriculostomy
20.2
55.7
43
22
G01*A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
45.0
43
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
40.6
180
622
G00.8
ICD-10 Finland
Other bacterial meningitis
+∞
38.7
37
*
AA1AD
NOMESCO Finland
CT of head and brain
2.2
36.2
451
2541
G00.2
ICD-10 Finland
Streptococcal meningitis
+∞
34.5
33
*
G00.3
ICD-10 Finland
Staphylococcal meningitis
+∞
34.5
33
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.4
29.2
76
182
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
8.5
29.2
38
46
R51.80
ICD-10 Finland
Headache
2.2
27.6
269
1356
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
26.9
265
1340
G01*A32.1
ICD-10 Finland
Listerial meningitis
+∞
25.1
24
*
3209X
ICD-9 Finland
Bacterial meningitis, Meningitis due to unspecified bacterium
+∞
25.1
24
*
G51.0
ICD-10 Finland
Bell palsy
4.4
23.2
59
139
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
23.0
22
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
40.8
22.7
28
7
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
21.7
253
1356
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.1
21.5
93
314
N03AX14
ATC
levetiracetam; systemic
4.1
21.4
60
152
32010
ICD-8 Finland
Meningitis, Pneumococcus
+∞
20.9
20
*
G01
ICD-10 Finland
Meningitis in bacterial diseases classified elsewhere
+∞
19.8
19
*
A69.2
ICD-10 Finland
Lyme disease
2.7
19.8
114
450
G00.0
ICD-10 Finland
Haemophilus meningitis
+∞
18.8
18
*
R50.9
ICD-10 Finland
Fever, unspecified
2.0
18.8
235
1288
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.4
17.2
63
192
A86
ICD-10 Finland
Unspecified viral encephalitis
22.2
16.9
24
11
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
5.9
16.7
30
52
3201A
ICD-9 Finland
Bacterial meningitis, Pneumococcal meningitis
+∞
15.7
15
*
3200A
ICD-9 Finland
Bacterial meningitis, Haemophilus meningitis
+∞
15.7
15
*
R51
ICD-10 Finland
Headache
2.6
15.7
95
385
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
38.5
15.4
19
5
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.2
14.9
39
94
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
6.0
14.8
26
44
A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
14.6
14
*
XA800
NOMESCO Finland
Neuropsychological investigation
2.7
14.1
75
284
04599
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Aseptic meningitis, unspecified
34.4
13.5
17
5
G91.0
ICD-10 Finland
Communicating hydrocephalus
9.8
13.2
26
27
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.1
13.0
136
696
N03AX12
ATC
[U] gabapentin; oral
1.8
12.8
223
1350
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
14.2
12.8
21
15
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
12.6
308
2045
N03AF01
ATC
carbamazepine; oral, rectal
2.5
12.3
78
323
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
12.3
267
1717
N03AX16
ATC
[U] pregabalin
1.6
12.3
303
2014
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
3.6
12.2
40
114
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
5.7
12.0
22
39
N03AB02
ATC
phenytoin; systemic
4.9
11.9
26
54
J01FF01
ATC
clindamycin; systemic
1.6
11.9
359
2506
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
30.3
11.7
15
5
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
11.5
293
1961
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
11.4
198
1196
N03AG01
ATC
valproic acid; systemic, rectal
2.2
11.2
95
447
N03AF02
ATC
oxcarbazepine; oral
2.9
11.2
52
184
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.9
11.1
137
742
WX882
NOMESCO Finland
High dependency care
3.2
11.1
44
142
R42
ICD-10 Finland
Dizziness and giddiness
1.6
11.0
290
1953
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
14.0
11.0
18
13
A41.9
ICD-10 Finland
Sepsis, unspecified
2.8
11.0
54
197
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
43.7
10.9
13
*
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
3.6
10.7
34
95
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
10.5
606
4820
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
10.5
118
619
N02AX02
ATC
tramadol; systemic, rectal
1.5
10.5
553
4322
N71
ICPC
Meningitis/encephalitis
110.9
10.4
11
*
N05CF01
ATC
zopiclone; oral
1.5
10.3
399
2929
G44.2
ICD-10 Finland
Tension-type headache
1.7
10.1
185
1131
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.6
10.0
58
230
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
4.9
9.8
21
43
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
9.7
681
5589
WX730
NOMESCO Finland
Conventional respirator
4.1
9.7
26
64
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
9.7
311
2188
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.0
9.5
105
548
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.1
9.4
39
129
A32.7
ICD-10 Finland
Listerial sepsis
100.7
9.4
10
*
N73
ICPC
Neurological infection other
100.7
9.4
10
*
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.5
9.4
59
244
G06.0
ICD-10 Finland
Intracranial abscess and granuloma
+∞
9.4
9
*
G01*A17.0
ICD-10 Finland
Tuberculous meningitis
+∞
9.4
9
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
3.3
9.3
34
104
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
3.9
9.3
27
71
XCK00
NOMESCO Finland
Perimetry
2.2
9.2
74
342
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
9.1
139
807
AAK00
NOMESCO Finland
Cranioplasty
36.9
9.0
11
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
8.9
457
3527
H02AB06
ATC
prednisolone; systemic
1.4
8.8
598
4850
G91.1
ICD-10 Finland
Obstructive hydrocephalus
10.8
8.8
16
15
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.7
8.6
178
1123
J01AA02
ATC
doxycycline; systemic
1.5
8.5
1001
8921
AAE05
NOMESCO Finland
Nasoendoscopic closure of cerebrospinal fluid fistula
+∞
8.3
8
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.0
8.3
88
452
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
8.3
237
1620
H02AB07
ATC
prednisone; oral
1.7
8.3
164
1024
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.1
8.2
72
345
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
22.2
8.0
11
5
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
3.6
7.9
25
70
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.2
7.8
62
285
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
4.1
7.8
21
52
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.5
7.7
49
204
ZXD05
NOMESCO Finland
Urgent procedure
1.4
7.7
370
2807
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.0
7.7
81
416
N03AE01
ATC
clonazepam; systemic
2.1
7.6
73
362
J01DB01
ATC
cefalexin; oral
1.5
7.6
1078
9817
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
18.5
7.6
11
6
N06AA09
ATC
amitriptyline; systemic
1.8
7.6
117
681
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
7.4
312
2307
G63.0*A69.2
ICD-10 Finland
Polyneuropathy (in) Lyme disease
13.4
7.4
12
9
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.3
7.3
55
247
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
3.0
7.3
32
110
J01DA01
ATC
[U] cefalexin
1.4
7.3
768
6621
AWC00
NOMESCO Finland
Reoperation of nervous system because of deep wound infection in the nervous system
+∞
7.3
7
*
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
7.3
7
*
B94.80
ICD-10 Finland
Late effects of bacterial meningitis
+∞
7.3
7
*
A32.1
ICD-10 Finland
Listerial meningitis and meningoencephalitis
+∞
7.3
7
*
3202A
ICD-9 Finland
Bacterial meningitis, Streptococcal meningitis
+∞
7.3
7
*
G09
ICD-10 Finland
Sequelae of inflammatory diseases of central nervous system
+∞
7.3
7
*
A02BC02
ATC
pantoprazole; systemic
1.4
7.1
863
7595
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
3.8
7.1
21
56
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.7
7.0
140
876
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
2.2
7.0
55
253
79199
ICD-8 Finland
Headache
3.7
6.9
21
57
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.6
6.9
191
1293
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
4.0
6.9
19
48
SPAT1255
SPAT
Intravenous administration of medicine
1.9
6.9
83
447
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.8
6.9
102
587
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.9
6.8
88
486
N03AX18
ATC
lacosamide; systemic
5.7
6.8
18
32
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
4.3
6.8
17
40
J02AC01
ATC
fluconazole; systemic
1.4
6.8
455
3644
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
1.9
6.7
86
472
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
2.6
6.7
37
144
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
3.9
6.7
19
49
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
6.7
343
2622
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
6.7
136
854
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
22.6
6.7
9
*
G50.0
ICD-10 Finland
Trigeminal neuralgia
2.9
6.7
30
105
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
4.0
6.6
18
45
A02BC01
ATC
omeprazole; systemic
1.4
6.5
306
2303
ZXC95
NOMESCO Finland
Use of surgical navigator
3.5
6.4
21
60
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
3.0
6.4
27
91
ZXA00
NOMESCO Finland
Right side
1.4
6.4
299
2248
WX892
NOMESCO Finland
Monitored bed care
1.8
6.4
93
533
J05AB01
ATC
aciclovir; systemic
1.4
6.3
259
1901
TKC20
NOMESCO Finland
Catheterisation of bladder
1.9
6.3
76
410
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
18.1
6.3
9
5
ABD40
NOMESCO Finland
Implantation of spinal injection device
+∞
6.3
6
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.5
6.2
38
156
0499X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Unspecified non-arthropod-borne viral diseases of central nervous system
12.6
6.1
10
8
9560/0-C72.4
ICD-O-3
Schwannoma, NOS, of acoustic nerve
10.1
6.0
11
11
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
6.0
545
4546
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
3.4
6.0
21
63
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
149
121
13.71
153.79
2.2
1.6
—
—
—
0
0
210
324
7.48
133.69
2.0
1.3
1457.22
491.41
mg/l
13.82
203
306
196
285
7.87
131.50
1.8
1.2
3.04
3.74
mmol/l
7.89
179
272
93
53
18.76
115.54
1.9
2.1
—
—
—
0
0
89
66
14.36
96.26
1.3
1.0
—
—
—
0
0
167
290
6.43
94.02
2.0
1.4
718.83
806.65
e6/l
0.06
132
223
163
286
6.34
90.74
1.9
1.4
651.88
8.28
e6/l
3.77
126
209
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
80
60
14.11
85.86
1.2
1.1
—
—
—
0
0
69
52
13.93
73.74
1.2
1.1
—
—
—
0
0
48
24
20.70
62.83
1.1
1.0
—
—
—
0
0
84
116
7.65
58.12
1.1
1.1
—
—
—
0
0
87
137
6.72
53.38
1.3
1.0
60.80
—
au/ml
—
5
0
50
41
12.62
50.65
1.5
1.1
—
—
—
0
0
44
32
14.18
47.79
1.3
1.0
—
—
—
0
0
43
33
13.42
45.27
1.3
1.0
—
—
—
0
0
36
27
13.67
38.34
1.2
1.1
—
—
—
0
0
77
163
4.95
34.46
4.7
5.7
11.00
11.31
mg/l
0.21
72
149
34
32
10.87
31.41
1.3
1.0
—
—
—
0
0
34
33
10.54
30.76
1.2
1.0
—
—
—
0
0
37
44
8.62
28.84
1.1
1.0
—
—
—
0
0
196
854
2.51
28.09
3.1
2.4
29.91
19.72
au/ml
0.73
21
89
181
783
2.51
26.26
1.7
1.3
66.83
42.92
au/ml
0.92
19
53
55
129
4.40
21.72
1.8
1.8
—
—
—
0
0
32
51
6.40
19.33
2.5
1.1
30.40
65.60
%
—
20
5
24
8
30.50
18.36
1.2
1.1
—
—
—
0
0
25
32
7.94
18.32
1.2
1.0
—
—
—
0
0
26
12
22.06
18.21
1.3
1.1
—
—
—
0
0
43
118
3.73
13.80
2.0
1.9
—
—
—
0
0
54
178
3.12
13.06
1.2
1.1
—
—
—
0
0
20
12
16.90
12.99
1.1
1.1
—
—
—
0
0
294
1922
1.68
12.77
2.2
1.9
—
—
—
0
0
65
251
2.67
11.83
2.0
1.5
—
—
—
0
0
19
14
13.74
11.46
1.2
1.1
—
—
—
0
0
759
6272
1.48
10.99
7.4
7.0
10.29
11.54
umol/l
3.47
723
6014
172
1013
1.80
10.73
4.0
2.8
10.48
10.80
g/l
0.42
165
944
76
340
2.31
10.15
1.6
1.6
—
—
—
0
0
32
91
3.58
9.81
1.1
1.0
—
—
—
0
0
476
3678
1.45
9.29
2.5
2.2
164.83
235.82
u/l
1.43
457
3498
644
5276
1.42
9.05
7.8
7.1
1.20
1.21
mmol/l
2.51
594
4894
707
5895
1.42
8.96
8.7
7.7
1.21
1.21
mmol/l
0.63
610
5116
221
1461
1.61
8.94
2.1
1.9
—
—
—
0
0
631
5176
1.41
8.68
6.0
5.4
35.51
35.99
g/l
1.21
596
4887
264
1832
1.55
8.65
2.1
2.2
29.48
29.53
s
0.03
257
1778
28
81
3.51
8.39
1.1
1.2
0.95
0.53
ratio
0.77
17
42
808
6940
1.41
8.37
6.5
5.5
6.71
6.66
mmol/l
0.23
769
6604
483
3800
1.42
8.34
2.8
2.7
68.55
82.01
u/l
0.25
445
3560
16
17
9.51
8.28
1.3
1.0
—
—
—
0
0
27
77
3.56
8.27
1.2
1.1
1.60
1.09
u/l
—
10
39
16
18
8.98
8.04
1.3
1.0
—
—
—
0
0
206
1373
1.59
8.01
9.7
9.7
1.02
0.97
mmol/l
0.07
179
1131
796
6860
1.39
7.83
11.6
10.1
4.25
4.08
e9/l
1.22
708
6004
15
16
9.47
7.78
1.0
1.0
—
—
—
0
0
975
8719
1.42
7.57
5.5
4.4
11.97
11.34
mm/h
0.71
928
8206
79
406
2.00
7.48
2.1
1.9
—
—
—
0
0
187
1241
1.59
7.39
10.0
10.2
95.48
95.71
%
0.16
180
1201
74
375
2.03
7.29
2.1
1.7
—
—
—
0
0
641
5375
1.36
7.25
16.0
13.8
1.21
1.22
inr
0.22
550
4455
17
26
6.61
7.12
1.1
1.0
18.71
7.16
mg/g
2.02
17
26
203
1389
1.54
7.00
10.0
9.6
5.05
5.12
kpa
0.43
196
1341
203
1389
1.54
7.00
10.0
9.6
12.80
12.26
kpa
0.73
196
1344
24
71
3.42
6.99
1.3
1.0
1678.79
1519.01
miu/ml
0.26
24
71
1000
9051
1.40
6.71
10.3
8.5
78.45
78.32
u/l
0.04
963
8636
58
281
2.11
6.47
5.9
6.9
233.20
408.18
iu/ml
—
10
40
136
863
1.64
6.45
2.2
1.6
—
—
—
0
0
199
1392
1.50
6.17
2.1
1.9
—
—
—
0
0
10
8
12.58
6.08
1.5
1.1
—
—
—
0
0
10
8
12.58
6.08
1.1
1.0
—
—
—
0
0
73
396
1.89
5.96
3.2
2.8
—
—
—
0
0
171
1172
1.53
5.84
11.2
10.4
117.94
122.14
g/l
1.80
166
1147
110
679
1.67
5.81
1.7
1.6
—
—
—
0
0
34
139
2.48
5.64
1.4
1.5
281.04
280.79
mosm/kgh2o
0.02
26
109
269
2026
1.41
5.64
3.7
3.8
0.82
0.82
mmol/l
0.00
258
1931
9
7
12.93
5.58
1.1
1.0
—
—
—
0
0
535
4489
1.32
5.55
3.9
3.7
23.46
61.11
ng/l
1.74
376
3067
21
67
3.17
5.48
2.6
3.0
893.05
962.01
u/ml
0.09
21
67
56
287
1.99
5.42
1.7
1.6
—
—
—
0
0
377
3039
1.33
5.11
4.6
4.2
91.52
90.90
%
0.20
372
2980
106
679
1.61
4.87
11.9
13.1
15.67
16.03
%
0.61
101
654
119
792
1.55
4.66
11.1
11.9
1.23
1.33
%
0.54
119
787
8
8
10.05
4.52
1.0
1.0
—
—
—
0
0
65
373
1.78
4.50
2.4
1.7
0.23
0.23
g/l
0.44
60
357
29
123
2.39
4.50
1.9
7.7
7.71
7.25
mmol/l
0.10
19
103
73
437
1.71
4.38
2.4
2.2
287.15
469.37
ug/l
0.61
67
416
590
5134
1.26
4.29
2.2
2.1
97.39
96.09
pmol/l
0.23
320
2762
317
2551
1.32
4.25
1.6
1.5
2.50
2.44
g/l
0.18
200
1622
57
321
1.81
4.22
1.9
1.7
—
—
—
0
0
152
1087
1.45
4.22
7.4
8.3
8.54
9.24
mmol/l
0.68
147
1042
59
336
1.79
4.21
2.1
1.8
—
—
—
0
0
21
79
2.68
4.17
1.0
1.2
—
—
—
0
0
10
17
5.92
4.13
2.6
1.4
—
—
—
0
0
65
386
1.72
4.03
2.5
1.6
1.20
1.20
g/l
0.06
60
368
62
366
1.73
3.93
1.3
1.3
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
61
359
1.73
3.91
2.5
3.1
0.30
0.37
iu/ml
1.32
34
192
77
483
1.63
3.90
2.9
2.0
1.31
2.01
ug/l
0.45
67
436
14
37
3.81
3.89
2.2
3.0
9.70
10.09
kpa
0.30
14
37
14
37
3.81
3.89
2.2
3.0
4.45
4.93
kpa
1.15
14
37
211
1622
1.36
3.85
6.2
6.3
1.01
1.03
mmol/l
0.46
200
1508
109
744
1.51
3.83
10.1
7.9
24.89
24.42
mmol/l
0.70
103
712
180
1350
1.38
3.83
4.6
4.6
239.19
249.57
u/l
0.45
170
1287
9
15
6.03
3.82
1.2
1.1
—
—
—
0
0
366
3042
1.28
3.80
2.5
2.2
2.89
2.85
mg/l
0.10
321
2634
158
1171
1.40
3.61
2.7
2.6
57.01
78.61
u/l
0.20
136
990
376
3154
1.27
3.59
3.0
2.8
337.23
343.36
umol/l
0.62
333
2821
20
80
2.52
3.55
1.5
2.4
555.07
582.81
e6/l
0.06
14
67
20
80
2.52
3.55
1.1
1.0
209.77
290.54
ng/l
0.72
13
54
9
17
5.32
3.51
1.1
1.1
—
—
—
0
0
818
7485
1.23
3.48
6.2
4.5
676.44
1867.14
e6/l
0.70
16
109
20
81
2.49
3.47
1.1
1.0
49.64
41.47
ng/l
0.17
12
52
20
81
2.49
3.47
1.1
1.0
639.67
673.64
ng/l
0.13
15
55
78
508
1.57
3.42
1.6
2.1
1.75
1.50
g/l
1.26
70
451
254
2040
1.30
3.41
3.6
2.9
1.02
1.11
e6/l
0.17
128
1064
205
1608
1.32
3.26
2.8
2.5
135.88
121.65
ug/g
0.31
161
1306
58
358
1.65
3.18
1.3
1.3
—
—
—
0
0
28
137
2.07
3.18
1.3
1.4
—
—
—
0
0
19
80
2.39
3.06
1.5
2.5
194.54
232.65
e6/l
0.28
13
71
54
331
1.66
3.05
1.4
1.3
—
—
—
0
0
628
5641
1.21
3.05
3.2
3.1
116.02
129.92
ug/l
1.10
592
5303
9
21
4.31
2.99
1.4
1.3
—
—
—
0
0
330
2780
1.25
2.98
1.7
1.8
1.12
1.20
mg/l
0.28
252
2146
395
3398
1.23
2.94
4.8
3.9
0.00
0.01
estimate
1.34
121
1189
8
17
4.73
2.92
1.4
1.1
—
—
—
0
0
8
17
4.73
2.92
1.6
2.9
—
—
—
0
0
39
222
1.78
2.88
1.9
2.0
5.00
5.08
mmol/24h
0.05
30
199
390
3366
1.22
2.79
3.0
3.2
1208.15
1147.89
ng/l
0.05
333
2872
205
1644
1.29
2.78
1.7
1.9
1.44
1.48
%
0.36
182
1447
689
6280
1.20
2.77
4.5
3.8
0.00
6.35
estimate
1.58
136
1293
58
372
1.58
2.76
1.4
1.4
268.48
277.99
ug/g
0.13
37
219
896
8370
1.21
2.74
3.9
3.4
51.67
49.20
u/l
0.38
857
7956
153
1184
1.33
2.69
4.0
3.6
1.61
1.92
mmol/l
0.57
141
1009
273
2279
1.25
2.66
3.8
3.9
234.21
467.92
ng/l
1.39
192
1721
50
313
1.62
2.64
1.6
1.6
10822.82
12334.66
e6/l
0.15
38
226
75
517
1.48
2.59
1.4
1.2
0.26
1.17
u/ml
—
8
28
5
7
7.17
2.55
1.8
1.7
18.72
23.80
mg/l
—
5
7
37
216
1.73
2.54
2.3
1.9
—
—
—
0
0
14
56
2.52
2.53
2.0
1.7
—
—
—
0
0
14
56
2.52
2.53
2.0
1.7
—
—
—
0
0
14
56
2.52
2.53
2.0
1.7
—
—
—
0
0
14
56
2.52
2.53
2.0
1.7
—
—
—
0
0
230
1895
1.26
2.51
3.9
3.0
2.50
2.47
e6/l
0.02
100
914
225
1851
1.26
2.49
2.0
1.7
1099.90
1187.42
nmol/l
0.87
171
1414
434
3823
1.20
2.47
4.5
3.3
33.59
71.98
e6/l
1.27
338
2923
378
3288
1.21
2.46
4.2
3.2
0.29
0.40
e6/l
0.66
280
2399
108
804
1.37
2.46
4.5
3.6
5.21
5.15
kpa
0.32
102
780
87
626
1.42
2.42
1.5
1.4
—
—
—
0
0
63
426
1.50
2.41
1.7
1.7
—
—
—
0
0
40
244
1.66
2.36
1.8
1.6
—
—
—
0
0
24
125
1.94
2.36
2.0
2.3
20.55
19.23
mg/l
—
6
50
115
872
1.35
2.34
1.3
1.3
116.93
218.66
u/ml
1.89
109
813
58
388
1.52
2.34
1.5
1.2
48.40
13.75
u/ml
—
6
15
335
2896
1.21
2.32
2.8
2.4
—
—
—
0
0
175
1411
1.28
2.29
2.6
2.9
6.64
8.07
umol/l
0.51
150
1254
676
6217
1.17
2.28
4.6
3.7
0.00
0.00
estimate
0.50
131
1269
20
99
2.04
2.26
1.8
1.6
—
—
—
0
0
20
99
2.04
2.26
1.8
1.6
—
—
—
0
0
20
99
2.04
2.26
1.8
1.6
—
—
—
0
0
55
368
1.52
2.23
1.5
1.2
1.65
7.75
u/ml
—
10
56
93
688
1.38
2.22
4.5
3.5
1.56
1.77
mmol/l
0.26
72
508
306
2633
1.21
2.22
3.5
2.7
4.95
5.46
e6/l
0.38
287
2415
29
165
1.77
2.20
1.9
1.9
—
—
—
0
0
685
6318
1.17
2.20
4.6
3.8
0.00
0.26
estimate
0.54
127
1199
51
337
1.53
2.19
1.4
1.4
—
—
—
0
0
605
5527
1.17
2.19
3.0
2.8
—
—
estimate
—
0
0
377
3312
1.19
2.18
1.7
1.7
20.87
20.38
nmol/l
0.23
324
2841
74
530
1.42
2.14
2.2
1.9
3.45
8.14
iu/ml
2.32
23
125
319
2768
1.20
2.11
4.9
3.8
1.02
1.56
kg/l
0.50
207
1861
16
75
2.15
2.09
1.9
2.1
—
—
—
0
0
171
1392
1.26
2.08
5.2
4.7
32.68
31.64
%
0.48
110
942
151
1211
1.28
2.08
2.5
2.2
359.20
376.86
nmol/l
0.39
140
1140
959
9108
1.18
2.07
4.6
4.3
14.64
14.72
pmol/l
0.51
885
8455
589
5387
1.16
2.07
2.8
2.5
76.25
76.41
nmol/l
0.05
530
4912
11
44
2.51
2.01
2.1
1.8
—
—
—
0
0
11
44
2.51
2.01
2.1
1.8
—
—
—
0
0
54
369
1.48
2.01
1.5
1.2
5.48
2.58
u/ml
—
8
33
10
38
2.64
2.00
1.5
1.2
—
—
—
0
0
39
248
1.59
2.00
1.8
1.5
—
—
—
0
0
254
2169
1.21
1.99
1.4
1.3
6.85
12.39
u/ml
0.86
98
858
810
7603
1.16
1.99
3.2
3.1
—
—
—
0
0
114
890
1.31
1.94
1.5
1.5
—
—
—
0
0
39
250
1.58
1.94
12.0
9.8
11.45
11.50
mmol/l
0.03
33
226
39
250
1.58
1.94
12.0
9.8
103.94
105.61
mmol/l
1.06
33
226
11
45
2.46
1.93
2.2
1.8
—
—
—
0
0
329
2889
1.18
1.89
1.3
1.3
2.41
1.81
u/ml
0.19
83
813
19
100
1.91
1.86
1.2
1.1
106.05
105.19
pmol/l
0.04
19
100
145
1177
1.26
1.83
4.4
4.6
18.18
20.43
ug/l
0.07
113
966
234
2000
1.21
1.82
2.8
2.6
13.13
13.56
umol/l
0.33
227
1874
219
1862
1.21
1.80
2.8
2.6
2.34
2.33
g/l
0.04
211
1743
142
1154
1.26
1.78
2.1
2.4
0.22
0.21
g/l
0.45
132
1085
25
147
1.71
1.74
1.5
1.4
—
—
—
0
0
23
132
1.76
1.74
1.4
1.7
53.00
57.19
%
0.16
16
95
24
140
1.73
1.72
1.5
1.4
—
—
—
0
0
24
140
1.73
1.72
1.5
1.4
—
—
—
0
0
5
13
3.86
1.71
1.4
1.0
—
—
—
0
0
36
235
1.55
1.69
3.3
4.3
144.38
1640.70
u/ml
0.79
31
223
24
141
1.71
1.69
1.5
1.4
—
—
—
0
0
39
260
1.51
1.67
1.4
1.6
—
—
—
0
0
1189
11574
1.22
1.64
22.3
15.5
24.08
23.64
mg/l
0.18
1027
9512
18
98
1.85
1.62
1.1
1.5
—
—
—
0
0
31
198
1.58
1.60
1.9
1.6
—
—
—
0
0
33
214
1.56
1.60
1.3
1.3
—
—
—
0
0
33
214
1.56
1.60
1.3
1.3
—
—
—
0
0
462
4214
1.15
1.59
3.8
3.5
33.68
32.84
u/l
0.17
439
4000
42
288
1.47
1.59
2.3
1.7
—
—
—
0
0
200
1711
1.20
1.55
2.9
2.7
21.91
23.38
%
0.67
193
1611
57
416
1.39
1.55
1.3
1.3
141.49
234.84
miu/ml
1.92
29
191
24
145
1.67
1.54
1.5
1.4
—
—
—
0
0
13
64
2.04
1.54
1.3
1.3
—
—
—
0
0
13
64
2.04
1.54
1.3
1.3
—
—
—
0
0
270
2373
1.17
1.53
1.7
1.7
30932650.57
24044144.51
pmol/l
0.08
236
2013
74
565
1.33
1.52
2.4
2.1
40.69
39.57
u/l
0.20
65
509
24
147
1.64
1.48
1.5
1.4
—
—
—
0
0
266
2345
1.17
1.46
1.5
1.3
17.79
30.47
iu/ml
2.80
77
722
11
52
2.12
1.44
2.0
2.4
—
—
—
0
0
6
22
2.73
1.43
1.3
1.4
—
—
—
0
0
78
606
1.30
1.43
4.5
3.6
50.90
48.63
%
0.40
78
592
150
1265
1.21
1.37
7.9
6.8
—
—
—
0
0
52
383
1.37
1.37
2.4
2.3
1108.82
5540.51
u/l
1.91
18
154
114
936
1.24
1.35
2.3
2.4
6.19
7.75
ug/l
0.47
96
849
19
113
1.69
1.32
3.0
2.3
—
—
—
0
0
55
412
1.35
1.31
4.1
2.8
1.49
0.90
g/l
0.31
45
362
1079
11088
0.87
1.29
4.4
4.3
1.40
1.32
mmol/l
1.69
1012
10334
61
467
1.32
1.27
4.0
3.7
485.73
3166.64
u/ml
0.68
55
407
22
138
1.60
1.26
1.2
1.2
—
—
—
0
0
52
389
1.35
1.26
3.4
3.8
35.72
43.30
mg/l
0.41
44
328
55
416
1.34
1.24
1.3
1.3
—
—
—
0
0
8
36
2.23
1.24
1.8
1.0
—
—
—
0
0
118
983
1.22
1.24
3.2
2.9
65.59
66.95
g/l
0.98
106
915
109
901
1.23
1.23
3.9
4.1
74.72
86.87
ng/l
1.23
98
797
76
603
1.28
1.22
1.8
1.7
0.33
0.35
mg/l
0.10
43
295
16
93
1.73
1.21
1.4
1.2
—
—
—
0
0
511
4761
1.12
1.20
4.5
3.6
0.00
0.02
estimate
3.04
100
1069
69
543
1.29
1.19
9.3
6.2
1.93
1.57
%
1.43
64
512
53
402
1.33
1.19
3.4
2.6
9.80
10.44
g/l
0.45
44
367
47
350
1.36
1.18
3.1
3.7
1.81
2.33
ratio
0.40
25
197
16
94
1.71
1.17
1.4
1.2
—
—
—
0
0
28
190
1.48
1.17
1.4
1.3
—
—
—
0
0
1148
11212
1.15
1.14
18.2
14.8
84.26
83.22
ml/min/173m2
0.97
1079
10380
55
423
1.31
1.13
1.6
1.5
0.12
0.09
iu/ml
0.11
14
59
25
167
1.51
1.12
1.8
1.8
—
—
—
0
0
18
111
1.63
1.12
1.3
1.4
76824.50
95816.02
e6/l
—
10
55
22
143
1.55
1.12
1.1
1.7
24.55
34.23
ng/l
0.52
22
143
51
389
1.32
1.11
3.4
3.8
42.05
61.35
mg/l
0.60
43
327
39
285
1.38
1.11
2.3
2.3
135.07
129.42
g/l
0.56
29
229
117
987
1.20
1.10
3.2
2.4
0.19
0.47
e6/l
1.70
106
947
52
399
1.32
1.09
5.1
4.1
1.23
1.37
mmol/l
0.59
52
390
60
470
1.29
1.09
3.8
2.5
4.33
4.24
g/l
0.30
51
437
60
470
1.29
1.09
3.8
2.5
7.27
7.25
g/l
0.04
51
437
60
470
1.29
1.09
3.8
2.5
3.85
3.69
g/l
0.14
51
437
128
1489
0.85
1.05
2.0
2.0
3.89
3.57
ratio
1.44
98
1182
112
949
1.20
1.02
3.1
2.7
63.23
68.53
ml/min/173m2
0.82
43
414
9
47
1.92
1.02
2.7
4.8
—
—
—
0
0
32
231
1.39
1.00
11.6
4.2
3.17
2.47
mmol/l
0.45
17
157
40
301
1.34
0.98
1.5
1.2
21.13
57.24
u/ml
—
9
29
0
30
0.00
0.97
0.0
1.2
—
—
—
0
0
441
4123
1.10
0.94
3.7
3.5
7.74
7.89
mmol/l
0.26
370
3544
19
125
1.53
0.94
2.7
2.3
9.28
7.10
umol/l
0.26
13
93
43
554
0.77
0.93
1.1
1.2
1.53
1.51
g/l
0.17
43
554
433
4050
1.10
0.92
4.1
3.6
2.35
2.35
mmol/l
0.50
391
3711
13
78
1.67
0.91
1.5
1.9
—
—
—
0
0
1197
11763
1.15
0.91
23.7
18.1
139.55
139.69
mmol/l
1.16
1188
11558
24
168
1.44
0.90
1.1
1.4
25.81
24.99
u/l
0.04
19
143
21
143
1.48
0.90
1.9
1.5
381.29
317.76
mu/l
0.40
14
121
6
29
2.07
0.89
2.0
2.1
22.98
17.16
umol/l
—
6
29
6
30
2.00
0.87
39.0
6.5
6.42
5.28
kpa
—
6
30
12
72
1.67
0.85
2.2
1.5
1398559.83
1224609.80
iu/ml
—
6
5
1140
11605
0.89
0.84
5.1
5.0
1.43
1.44
mmol/l
0.55
1067
10884
37
283
1.32
0.84
1.4
1.4
—
11.99
—
0
6
55
444
1.25
0.83
1.7
1.7
5.79
11.00
u/ml
—
7
110
28
206
1.37
0.81
1.1
1.1
92.38
106.65
iu/ml
—
8
45
55
446
1.24
0.80
3.7
2.6
2.63
2.89
g/l
1.44
46
413
8
47
1.71
0.80
1.1
1.1
—
—
—
0
0
8
48
1.67
0.78
2.8
1.5
39.08
41.14
g/l
—
8
48
46
569
0.80
0.75
1.1
1.2
0.87
0.90
g/l
0.41
46
569
56
460
1.23
0.74
1.9
1.6
275.22
280.11
mu/l
0.06
51
424
5
24
2.09
0.74
1.8
1.3
—
—
—
0
0
1097
10758
1.10
0.73
5.7
5.3
1.83
1.88
mu/l
0.71
1027
10058
12
76
1.58
0.71
2.0
1.6
8.03
6.32
u/l
0.17
12
64
18
126
1.43
0.70
1.3
1.3
4278.92
1795.70
e6/l
0.50
13
81
9
58
1.56
0.70
1.8
3.1
0.78
1.15
%
—
9
58
1196
11789
1.12
0.69
23.8
18.3
3.96
3.97
mmol/l
0.26
1182
11561
5
27
1.85
0.68
1.2
1.2
—
7.47
—
0
7
1147
11645
0.90
0.68
5.2
5.1
4.70
4.67
mmol/l
0.46
1080
10989
42
514
0.81
0.65
1.1
1.1
0.75
0.67
ratio
—
5
60
14
95
1.48
0.64
1.3
1.5
—
—
—
0
0
240
2224
1.10
0.63
1.7
1.5
—
—
—
0
0
12
176
0.68
0.62
1.0
1.1
—
—
—
0
0
8
49
1.64
0.62
2.6
2.0
121.95
61.67
ug/l
—
8
49
8
49
1.64
0.62
1.1
1.9
—
—
—
0
0
10
63
1.59
0.62
1.0
1.1
—
—
—
0
0
1162
11779
0.91
0.61
5.7
5.7
2.77
2.75
mmol/l
0.29
1084
11064
8
50
1.60
0.61
1.3
1.2
—
—
—
0
0
8
50
1.60
0.61
1.3
1.2
—
—
—
0
0
71
612
1.17
0.60
1.1
1.1
—
1.03
—
0
6
136
1228
1.12
0.59
2.6
2.4
13.30
13.54
nmol/l
0.14
122
1123
13
89
1.47
0.58
2.2
2.5
21.75
32.37
mg/l
—
8
62
8
54
1.48
0.57
1.0
1.1
112.88
95.57
%
—
8
42
17
124
1.38
0.56
1.1
1.2
—
—
—
0
0
13
90
1.45
0.55
1.1
1.1
8.62
5.73
iu/ml
—
5
24
10
148
0.67
0.55
1.6
1.5
46.51
54.70
ug/l
—
10
148
8
126
0.63
0.54
1.3
1.3
—
—
—
0
0
6
38
1.58
0.54
1.2
1.1
—
—
—
0
0
61
527
1.16
0.52
3.7
3.4
1.02
1.02
ratio
1.26
56
494
9
64
1.41
0.51
1.3
1.3
—
47.50
—
0
8
11
75
1.47
0.50
1.3
1.1
—
—
—
0
0
15
202
0.74
0.50
1.6
1.6
—
—
—
0
0
6
41
1.47
0.50
2.3
1.3
11.53
8.95
ug/l
—
6
41
95
851
1.13
0.49
1.2
1.2
78.98
137.12
u/ml
1.85
35
338
14
101
1.39
0.49
1.0
1.1
—
—
—
0
0
61
530
1.16
0.49
3.8
3.3
25.41
25.21
mmol/l
0.16
61
511
72
634
1.14
0.49
1.0
1.1
—
—
—
0
0
7
46
1.52
0.48
3.7
2.2
0.94
1.01
ug/l
—
7
41
16
120
1.34
0.46
1.1
1.0
—
—
—
0
0
15
112
1.34
0.44
1.5
1.9
—
—
—
0
0
11
151
0.73
0.43
2.9
2.5
33.18
32.30
pg
0.42
11
151
42
488
0.86
0.42
2.0
1.8
7.61
5.16
mg/l
0.25
30
363
10
70
1.43
0.41
2.3
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
0.01
—
0
9
14
105
1.34
0.41
1.0
1.1
—
—
—
0
0
14
105
1.34
0.41
1.0
1.1
—
—
—
0
0
8
60
1.34
0.40
1.4
1.3
—
—
—
0
0
101
1104
0.91
0.40
1.6
1.8
3.67
3.49
mmol/l
0.59
69
794
1243
12332
1.09
0.39
25.6
19.9
75.98
77.15
umol/l
0.61
1236
12206
25
205
1.22
0.39
1.2
1.2
2.10
3.68
u/ml
—
10
72
34
288
1.19
0.39
3.9
2.9
1.55
1.57
mmol/l
0.06
34
279
10
137
0.73
0.39
1.4
1.6
—
—
—
0
0
100
915
1.10
0.38
4.9
4.0
1.21
1.23
mmol/l
2.13
89
791
11
81
1.36
0.36
1.9
2.7
9.25
8.22
mmol/l
0.28
11
81
13
99
1.32
0.35
4.1
3.6
15.71
12.69
index
—
7
67
41
358
1.15
0.34
3.4
2.6
0.01
0.01
g/l
0.14
36
324
238
2268
1.06
0.34
3.5
3.0
2.44
2.44
mmol/l
0.04
219
2050
91
837
1.09
0.33
3.2
3.0
154.73
186.93
ng/l
0.37
77
769
10
74
1.35
0.32
2.0
1.6
—
—
—
0
0
81
742
1.10
0.32
3.2
3.6
4.42
4.57
pmol/l
0.48
66
655
18
219
0.82
0.31
1.6
1.6
—
—
—
0
0
400
3877
1.04
0.30
4.5
4.3
14.06
9.04
mg/mmol
0.72
260
2441
36
409
0.88
0.29
1.3
1.5
—
—
—
0
0
23
194
1.19
0.29
1.3
1.1
2.69
2.29
eliau/ml
—
8
83
7
57
1.23
0.29
1.1
1.1
—
—
—
0
0
1261
12677
0.93
0.28
30.9
23.7
135.34
136.74
g/l
2.76
1255
12568
14
112
1.25
0.28
1.0
1.1
—
—
—
0
0
13
103
1.26
0.28
1.0
1.1
—
—
—
0
0
1261
12676
0.93
0.27
30.8
23.6
6.95
6.69
e9/l
3.42
1247
12432
8
64
1.25
0.27
4.5
2.0
—
—
—
0
0
8
64
1.25
0.27
4.5
2.0
—
—
—
0
0
126
1188
1.07
0.26
3.6
3.2
—
—
—
0
0
30
262
1.15
0.26
1.3
1.4
180.25
158.97
au/ml
0.65
12
71
1261
12674
0.93
0.26
31.4
24.1
40.40
40.77
%
1.64
1255
12559
1261
12674
0.93
0.26
30.7
23.5
4.51
4.54
e12/l
1.22
1245
12435
13
104
1.25
0.26
3.2
2.5
947.38
1136.85
mg
0.15
13
104
10
77
1.30
0.26
2.0
1.6
—
—
—
0
0
5
74
0.67
0.26
2.2
1.8
62.00
103.28
ng/l
—
5
74
1261
12672
0.93
0.25
30.6
23.5
90.87
90.95
fl
0.25
1254
12563
29
330
0.88
0.25
1.7
2.0
2.42
20.39
iu/l
0.55
13
140
45
406
1.11
0.25
1.6
1.4
11.24
8.54
u/l
0.54
38
330
26
298
0.87
0.25
1.2
1.3
—
—
—
0
0
24
207
1.16
0.25
3.3
3.4
0.84
0.84
nmol/l
0.00
19
170
1233
12261
1.06
0.24
14.9
12.1
27.80
27.37
u/l
0.24
1203
11972
14
169
0.83
0.24
2.1
1.8
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
1261
12666
0.94
0.22
30.8
23.6
253.12
250.97
e9/l
0.54
1247
12456
39
430
0.90
0.22
1.6
1.6
1008.23
1014.40
mu/l
0.01
30
347
61
657
0.93
0.21
1.6
1.4
24.74
26.49
iu/l
0.16
54
563
307
3157
0.96
0.21
4.2
4.2
21.53
21.26
%
0.10
139
1376
12
98
1.23
0.21
2.3
1.7
—
—
—
0
0
5
43
1.16
0.21
1.6
1.1
0.33
0.29
g/l
—
5
35
21
240
0.87
0.20
1.0
1.1
2.33
0.81
u/ml
0.48
12
105
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
22
249
0.88
0.19
1.0
1.1
13.82
4.80
u/ml
0.62
13
136
6
52
1.15
0.19
1.0
1.1
—
—
—
0
0
25
280
0.89
0.18
2.9
2.4
46.07
122.48
ug/min
1.61
13
173
34
309
1.10
0.18
3.1
3.4
9.25
1.99
index
0.58
16
170
7
60
1.17
0.17
1.0
1.1
98.86
217.56
iu/ml
—
7
60
23
205
1.12
0.17
1.2
1.2
4.67
5.80
u/ml
—
9
86
38
350
1.09
0.16
1.6
1.5
—
—
—
0
0
16
181
0.88
0.14
1.3
1.4
0.51
10.38
nmol/l
0.50
16
174
518
5111
1.02
0.13
1.9
1.9
1.47
1.39
mmol/l
0.45
444
4386
10
117
0.85
0.13
3.9
3.4
—
—
—
0
0
12
104
1.16
0.12
1.2
1.4
198.42
162.84
pmol/l
0.58
12
104
26
239
1.09
0.12
4.2
3.0
8.07
7.36
mmol/l
0.47
26
232
26
282
0.92
0.12
1.3
1.5
—
—
—
0
0
17
189
0.90
0.12
1.2
1.4
—
0.41
—
0
14
14
157
0.89
0.11
1.3
1.4
0.14
0.29
nmol/l
—
8
127
10
86
1.16
0.11
2.0
1.6
—
—
—
0
0
142
1383
1.03
0.10
2.3
2.1
—
—
—
0
0
30
280
1.07
0.10
1.2
1.1
1.43
1.98
u/ml
0.26
20
156
26
278
0.93
0.09
1.2
1.3
234.18
262.43
u/ml
0.29
17
167
35
331
1.06
0.09
1.3
1.1
—
—
—
0
0
58
602
0.96
0.08
2.0
2.0
—
—
—
0
0
242
2384
1.02
0.08
3.1
3.1
0.64
0.72
ug/l
1.10
156
1414
7
67
1.05
0.08
5.9
4.0
0.71
0.88
index
—
7
67
124
1268
0.98
0.08
2.3
2.0
—
—
—
0
0
6
70
0.86
0.07
1.3
1.3
13.17
9.37
mm/h
—
6
70
8
74
1.08
0.07
1.3
1.7
10.72
7.09
u/l
—
8
59
8
75
1.07
0.07
1.3
1.1
—
—
—
0
0
25
235
1.07
0.07
1.0
1.1
0.35
1.85
u/ml
2.26
11
120
1114
11173
0.98
0.07
5.3
5.0
5.95
5.92
mmol/l
0.27
1033
10367
7
82
0.85
0.07
1.0
1.2
—
—
—
0
0
25
236
1.06
0.06
5.8
3.7
21.48
25.61
mg/l
0.28
18
164
21
197
1.07
0.06
1.3
1.5
0.39
0.35
nmol/l
0.13
14
158
19
203
0.94
0.06
1.1
1.1
—
—
—
0
0
397
3948
1.01
0.03
5.6
5.1
1.98
2.13
ug/l
0.20
362
3603
14
132
1.06
0.02
1.4
1.4
1.25
1.47
nmol/l
0.36
14
120
34
331
1.03
0.02
1.3
1.1
—
—
—
0
0
27
262
1.03
0.02
1.4
1.5
54.85
58.19
ug/l
0.23
21
211
1104
11051
0.99
0.01
6.5
6.2
39.26
39.03
mmol/mol
0.37
1039
10433
24
247
0.97
0.01
1.3
1.4
1.08
1.22
ratio
0.40
14
156
24
247
0.97
0.01
1.3
1.4
0.93
0.95
ratio
0.10
13
156
24
247
0.97
0.01
1.3
1.4
1.12
1.17
ratio
0.18
13
156
72
728
0.99
0.01
2.1
2.0
—
—
—
0
0
16
154
1.04
0.00
1.1
1.1
—
—
—
0
0
35
348
1.01
0.00
3.1
2.6
0.00
0.00
g/l
-0.00
29
302
41
409
1.00
0.00
1.7
2.0
197.61
208.53
pmol/l
0.31
41
389
60
599
1.00
0.00
1.5
1.4
—
—
—
0
0
13
133
0.98
0.00
1.1
1.2
—
—
—
0
0
346
3465
1.00
0.00
3.9
3.2
0.10
0.04
estimate
0.23
99
1023
24
245
0.98
0.00
1.3
1.4
—
—
—
0
0
21
205
1.02
0.00
1.0
1.1
5.51
2.31
u/ml
—
10
102
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
84
0.95
-0.00
1.3
1.4
93.62
78.14
umol/l
—
8
84
0
6
0.00
-0.00
0.0
1.0
—
0.01
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
7.99
—
0
9
7
78
0.90
-0.00
2.7
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
2.38
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_MENINGBACT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MENINGBACT | 2.439 [2.05, 2.9] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.339 |
During the follow-up period (1.1.1998 — 31.12.2019), 366 out of 1921 females with G6_MENINGBACT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MENINGBACT | 2.511 [2.12, 2.98] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 528 out of 2305 males with G6_MENINGBACT died.
Mortality risk
Mortality risk for people of age
years, who have G6_MENINGBACT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.233% | 0.462% |
| 5 | 1.41% | 3.008% |
| 10 | 3.352% | 7.395% |
| 15 | 6.994% | 13.678% |
| 20 | 12.009% | 22.485% |
Relationships between endpoints
↥Index endpoint: G6_MENINGBACT – Bacterial meningitis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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