Meningitis

MENINGITIS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

2228

6. Filter based on genotype QC (FinnGen only)

1978

Control definitions (FinnGen only)

Control exclude
AB1_VIRAL_CNS

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 18175 8439 9598
Only index persons 14933 7258 7675
Unadjusted period prevalence (%)
Whole population 0.25 0.24 0.27
Only index persons 0.28 0.27 0.29
Median age at first event (years)
Whole population 29.98 32.14 27.70
Only index persons 26.99 29.97 24.16

-FinnGen-

Key figures

All Female Male
Number of individuals 1978 1117 861
Unadjusted period prevalence (%) 0.40 0.40 0.39
Median age at first event (years) 35.25 33.93 36.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2049
Matched controls
20485
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G03.9
ICD-10 Finland
Meningitis, unspecified
2019.1
307.7
463
*
32099
ICD-8 Finland
Meningitis, With no organism specified as cause
+∞
307.7
372
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
3183.2
304.8
287
*
TAB00
NOMESCO Finland
Lumbar puncture
9.7
275.3
352
430
32088
ICD-8 Finland
Meningitis, Alia definita
+∞
212.2
200
*
A87.9
ICD-10 Finland
Viral meningitis, unspecified
+∞
211.2
199
*
G01*A69.2
ICD-10 Finland
Meningitis (in) Lyme disease
+∞
123.2
117
*
32000
ICD-8 Finland
Meningitis, H. influenzae
+∞
117.8
112
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.1
105.2
332
929
G00.1
ICD-10 Finland
Pneumococcal meningitis
+∞
100.9
96
*
AA1AD
NOMESCO Finland
CT of head and brain
2.7
99.4
771
3687
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
95.6
91
*
R51.80
ICD-10 Finland
Headache
3.0
90.1
519
2106
3229X
ICD-9 Finland
Meningitis of unspecified cause, Meningitis, unspecified
+∞
89.2
85
*
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
39.6
88.2
54
14
AAF00
NOMESCO Finland
Ventriculostomy
18.2
76.9
62
35
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.6
71.8
143
273
A86
ICD-10 Finland
Unspecified viral encephalitis
+∞
69.1
66
*
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
15.0
56.3
50
34
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
9.1
49.4
61
69
G01*A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
45.0
43
*
R50.9
ICD-10 Finland
Fever, unspecified
2.3
44.7
397
1923
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
44.3
396
1923
G03.0
ICD-10 Finland
Nonpyogenic meningitis
+∞
43.9
42
*
G03.8
ICD-10 Finland
Meningitis due to other specified causes
+∞
42.9
41
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
15.7
42.6
37
24
N03AX14
ATC
levetiracetam; systemic
4.5
41.9
104
239
G00.8
ICD-10 Finland
Other bacterial meningitis
+∞
38.7
37
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
10.7
37.6
41
39
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.3
37.6
151
486
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
36.7
377
1925
G00.2
ICD-10 Finland
Streptococcal meningitis
+∞
34.5
33
*
G00.3
ICD-10 Finland
Staphylococcal meningitis
+∞
34.5
33
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.4
34.0
253
1126
XA800
NOMESCO Finland
Neuropsychological investigation
3.3
33.8
131
412
G02.0*B02.1
ICD-10 Finland
Zoster meningitis
+∞
32.4
31
*
R51
ICD-10 Finland
Headache
2.8
32.2
168
627
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
32.2
966
6945
G02.0*B01.0
ICD-10 Finland
Varicella meningitis
+∞
31.3
30
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
7.3
30.1
44
61
G03.1
ICD-10 Finland
Chronic meningitis
+∞
29.2
28
*
N71
ICPC
Meningitis/encephalitis
295.9
28.8
29
*
G51.0
ICD-10 Finland
Bell palsy
3.9
28.8
85
223
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
29.7
28.5
38
13
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
6.6
27.3
44
68
J05AB11
ATC
valaciclovir; oral
2.0
26.7
333
1812
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
26.7
474
2898
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
6.0
26.5
47
80
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.4
26.5
97
294
G01*A32.1
ICD-10 Finland
Listerial meningitis
+∞
25.0
24
*
0499X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Unspecified non-arthropod-borne viral diseases of central nervous system
+∞
25.0
24
*
3209X
ICD-9 Finland
Bacterial meningitis, Meningitis due to unspecified bacterium
+∞
25.0
24
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.3
24.9
199
909
N03AX12
ATC
[U] gabapentin; oral
1.9
24.5
347
1968
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.2
24.4
212
1003
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
49.0
24.3
29
6
N03AX18
ATC
lacosamide; systemic
7.8
23.8
33
43
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
4.0
23.6
68
175
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.3
22.6
58
137
N03AX16
ATC
[U] pregabalin
1.7
22.5
465
2954
H02AB06
ATC
prednisolone; systemic
1.6
22.1
942
7172
N02AX02
ATC
tramadol; systemic, rectal
1.6
22.1
850
6320
G02.0*A87.0
ICD-10 Finland
Enteroviral meningitis
+∞
21.9
21
*
R42
ICD-10 Finland
Dizziness and giddiness
1.7
21.7
452
2873
A69.2
ICD-10 Finland
Lyme disease
2.4
21.7
152
655
WX882
NOMESCO Finland
High dependency care
3.4
21.0
76
229
G02.0
ICD-10 Finland
Meningitis in viral diseases classified elsewhere
+∞
20.9
20
*
A87.8
ICD-10 Finland
Other viral meningitis
+∞
20.9
20
*
32010
ICD-8 Finland
Meningitis, Pneumococcus
+∞
20.9
20
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
4.1
20.8
58
146
G44.2
ICD-10 Finland
Tension-type headache
1.9
20.6
303
1734
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
5.6
20.6
39
71
N03AF02
ATC
oxcarbazepine; oral
3.1
20.2
86
286
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
4.7
19.9
46
100
G01
ICD-10 Finland
Meningitis in bacterial diseases classified elsewhere
+∞
19.8
19
*
G03.2
ICD-10 Finland
Benign recurrent meningitis [Mollaret]
+∞
19.8
19
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
19.8
303
1755
G05.1*B00.4
ICD-10 Finland
Herpesviral meningoencephalitis
106.0
19.6
21
*
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
4.3
19.5
50
118
5AB01, ,
NOMESCO Finland
40.5
19.5
24
6
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
16.0
18.8
30
19
G00.0
ICD-10 Finland
Haemophilus meningitis
+∞
18.8
18
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
18.4
215
1137
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
18.3
316
1896
G91.1
ICD-10 Finland
Obstructive hydrocephalus
14.5
18.1
30
21
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
17.9
461
3082
PA2AD
NOMESCO Finland
CT angiography of brain
5.4
17.8
35
66
04599
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Aseptic meningitis, unspecified
+∞
17.7
17
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
17.7
726
5403
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.7
17.2
95
365
A41.9
ICD-10 Finland
Sepsis, unspecified
2.9
17.2
81
286
N03AB02
ATC
phenytoin; systemic
5.0
16.9
36
73
B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
16.7
16
*
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
4.3
16.2
42
100
J05AB01
ATC
aciclovir; systemic
1.6
16.1
437
2950
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
16.1
393
2586
ZXD05
NOMESCO Finland
Urgent procedure
1.5
16.0
581
4191
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
16.0
470
3233
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
4.9
15.9
35
73
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
6.9
15.7
24
35
3201A
ICD-9 Finland
Bacterial meningitis, Pneumococcal meningitis
+∞
15.6
15
*
3200A
ICD-9 Finland
Bacterial meningitis, Haemophilus meningitis
+∞
15.6
15
*
ZXC95
NOMESCO Finland
Use of surgical navigator
4.3
15.5
40
95
SPAT1255
SPAT
Intravenous administration of medicine
2.2
15.4
136
647
J01FF01
ATC
clindamycin; systemic
1.5
15.3
523
3718
N01
ICPC
Headache
1.8
15.0
242
1419
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
3.4
14.9
54
163
J01DB01
ATC
cefalexin; oral
1.6
14.9
1649
14795
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
14.8
1038
8503
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
25.2
14.7
20
8
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
21.2
14.7
21
10
A02BC02
ATC
pantoprazole; systemic
1.5
14.6
1311
11233
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
14.6
220
1262
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.2
14.4
57
182
H02AB07
ATC
prednisone; oral
1.7
14.4
258
1560
WX872
NOMESCO Finland
Intensive care
2.3
14.3
106
468
WX730
NOMESCO Finland
Conventional respirator
4.1
14.2
38
93
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.6
14.1
80
312
N03AG01
ATC
valproic acid; systemic, rectal
2.1
14.1
132
643
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.3
14.1
103
453
ZX120
NOMESCO Finland
Intravenous
1.9
13.9
182
998
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
3.5
13.9
47
136
J01AA02
ATC
doxycycline; systemic
1.5
13.9
1498
13233
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
13.8
220
1283
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
13.8
373
2507
A39.0
ICD-10 Finland
Meningococcal meningitis
140.9
13.5
14
*
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
4.0
13.4
38
97
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
3.2
13.3
52
165
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.1
13.3
125
610
N05CF01
ATC
zopiclone; oral
1.5
13.2
579
4314
N06AA09
ATC
amitriptyline; systemic
1.9
13.2
176
972
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
13.1
478
3432
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.4
12.8
87
370
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.3
12.8
97
434
XCK00
NOMESCO Finland
Perimetry
2.2
12.8
109
512
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.9
12.6
160
868
G09
ICD-10 Finland
Sequelae of inflammatory diseases of central nervous system
70.3
12.6
14
*
H47.1
ICD-10 Finland
Papilloedema, unspecified
5.5
12.6
24
44
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
32.2
12.6
16
5
A87.0
ICD-10 Finland
Enteroviral meningitis
+∞
12.5
12
*
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
4.3
12.5
32
76
N73
ICPC
Neurological infection other
37.8
12.2
15
*
N03AE01
ATC
clonazepam; systemic
2.1
12.2
111
535
L04AX01
ATC
azathioprine; systemic
2.3
12.1
91
405
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
12.1
249
1560
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.1
12.0
121
607
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.9
11.9
165
922
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.0
11.7
130
674
N03AF01
ATC
carbamazepine; oral, rectal
2.2
11.7
102
484
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.7
11.6
62
235
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
11.6
136
720
AAA10
NOMESCO Finland
Biopsy through craniotomy
120.6
11.4
12
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.6
11.4
263
1696
TKC20
NOMESCO Finland
Catheterisation of bladder
2.0
11.4
119
604
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
11.4
228
1418
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
11.3
829
6737
D33.30
ICD-10 Finland
Acoustic neuroma
5.6
11.2
21
38
G40.10
ICD-10 Finland
Simple partial seizures
5.3
11.1
22
42
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.3
10.9
86
391
J01MA02
ATC
ciprofloxacin; systemic
1.4
10.9
689
5451
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
10.8
442
3232
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.7
10.7
184
1096
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
28.2
10.7
14
5
T78.4
ICD-10 Finland
Allergy, unspecified
2.1
10.7
96
461
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
10.6
631
4935
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
11.3
10.5
19
17
J01EA01
ATC
trimethoprim; systemic
1.5
10.5
440
3229
H53.2
ICD-10 Finland
Diplopia
2.4
10.3
72
311
R4150
NOMESCO Finland
Neuropsychological rehabilitation
4.3
10.3
26
61
AAF15
NOMESCO Finland
Ventriculoatrial shunt
13.2
10.2
17
13
S06.0
ICD-10 Finland
Concussion
1.7
10.1
207
1295
WX704
NOMESCO Finland
Intubation
1.8
10.1
156
902
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
10.0
817
6716
A32.7
ICD-10 Finland
Listerial sepsis
40.3
10.0
12
*
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
2.7
9.8
53
203
R11
ICD-10 Finland
Nausea and vomiting
1.7
9.7
169
1010
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
4.1
9.7
26
64
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
9.7
475
3584
B00.4
ICD-10 Finland
Herpesviral encephalitis
55.2
9.6
11
*
J01DA01
ATC
[U] cefalexin
1.3
9.6
1148
9969
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
2.2
9.5
76
348
G63.0*A69.2
ICD-10 Finland
Polyneuropathy (in) Lyme disease
15.1
9.5
15
10
AAE05
NOMESCO Finland
Nasoendoscopic closure of cerebrospinal fluid fistula
100.5
9.4
10
*
N02BE01
ATC
paracetamol; systemic, rectal
1.5
9.4
1745
16250
G01*A17.0
ICD-10 Finland
Tuberculous meningitis
+∞
9.4
9
*
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
5.2
9.4
19
37
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
4.0
9.3
26
66
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.2
9.3
77
358
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
4.5
9.3
22
49
B34.9
ICD-10 Finland
Viral infection, unspecified
2.4
9.3
64
275
Z3231
NOMESCO Finland
Registered nurse
1.4
9.3
472
3580
N05BA04
ATC
oxazepam; oral
1.4
9.3
467
3538
J01FA10
ATC
azithromycin; systemic
1.3
9.2
1091
9435
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
3.7
9.2
28
76
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
2.2
9.1
79
374
UKC02
NOMESCO Finland
Cystoscopy
1.6
9.0
246
1649
AAK00
NOMESCO Finland
Cranioplasty
18.7
8.9
13
7
ZZC00
NOMESCO Finland
Graft of fascia
24.1
8.9
12
5
ZZF00
NOMESCO Finland
Graft of adipose tissue
4.3
8.9
22
51
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.0
8.9
99
516
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
3.6
8.8
28
78
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
10.7
8.8
16
15
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
8.7
634
5093
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
1.9
8.7
111
605
R53
ICD-10 Finland
Malaise and fatigue
1.4
8.7
462
3529
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
8.7
171
1059
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
8.6
500
3875
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
11.6
8.6
15
13
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
16.3
8.5
13
8
WZC00
NOMESCO Finland
Treatment plan or consultation
1.3
8.5
680
5534
79199
ICD-8 Finland
Headache
3.5
8.5
28
80
6BA02, ,
NOMESCO Finland
10.1
8.5
16
16
S30.0
ICD-10 Finland
Contusion of lower back and pelvis
2.0
8.5
84
419
P01BA02
ATC
hydroxychloroquine; oral
1.7
8.4
143
850
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.0
8.4
90
462
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.1
8.4
78
380
G06.0
ICD-10 Finland
Intracranial abscess and granuloma
12.8
8.4
14
11
G05.1
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere
+∞
8.3
8
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
1.8
8.3
113
629
J01CA04
ATC
amoxicillin; systemic
1.4
8.3
1590
14646
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.5
8.3
266
1846
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
8.3
547
4324
UDC00
NOMESCO Finland
Ear microscopy
1.8
8.2
132
772
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
3.4
8.2
29
87
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
3.3
8.2
30
92
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
14.5
8.2
13
9
N06AX16
ATC
venlafaxine; oral
1.5
8.2
273
1909
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.5
8.2
274
1918
P01AB01
ATC
metronidazole; oral, rectal
1.3
8.2
714
5882
S18
ICPC
Laceration/cut
1.3
8.1
845
7129
Z2445
NOMESCO Finland
Psychologist
2.1
8.1
76
372
N99
ICPC
Neurological disease other
3.4
8.1
28
83
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.6
8.1
177
1126
ABE50
NOMESCO Finland
Occipitocervical decompression
17.2
8.1
12
7
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
4.0
8.1
22
55
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
8.1
350
2576
N06AX21
ATC
duloxetine; oral
1.5
8.1
224
1507
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.5
8.0
224
1508
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.3
8.0
56
243
N02BF01
ATC
gabapentin; oral
1.6
8.0
193
1257
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
3.5
8.0
26
74
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
2.2
8.0
66
308
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
3.4
7.9
28
84
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
2.8
7.9
38
137
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
7.9
540
4288
J02AC01
ATC
fluconazole; systemic
1.3
7.8
688
5663
R03AC02
ATC
salbutamol; inhalant
1.3
7.8
1033
8986
G43.9
ICD-10 Finland
Migraine, unspecified
1.8
7.8
119
686
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.6
7.8
193
1264
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
1.9
7.8
100
547
B02.1
ICD-10 Finland
Zoster meningitis
45.1
7.7
9
*
A06AD11
ATC
lactulose; oral
1.5
7.7
230
1572
WX892
NOMESCO Finland
Monitored bed care
1.7
7.7
131
780
N06AX11
ATC
mirtazapine; oral
1.3
7.7
617
5011
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.6
7.7
166
1053
B00.9
ICD-10 Finland
Herpesviral infection, unspecified
4.5
7.6
18
40
ZXA05
NOMESCO Finland
Left side
1.4
7.6
392
2969
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
1.9
7.6
92
493
N30.0
ICD-10 Finland
Acute cystitis
1.5
7.5
290
2085
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
4.1
7.5
20
49
DPA30
NOMESCO Finland
Sphenotomy
4.3
7.5
19
45
H04.10
ICD-10 Finland
Dry eye syndrome
1.5
7.5
210
1416
M01AE02
ATC
naproxen; oral, rectal
1.3
7.5
1048
9168
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
2.8
7.4
35
125
B94.1
ICD-10 Finland
Sequelae of viral encephalitis
80.4
7.4
8
*
R41.0
ICD-10 Finland
Disorientation, unspecified
2.4
7.4
51
220
N03AX09
ATC
lamotrigine; oral
1.9
7.4
97
534
A02BC01
ATC
omeprazole; systemic
1.4
7.4
446
3466
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
2.4
7.4
48
202
R40.2
ICD-10 Finland
Coma, unspecified
4.0
7.3
20
50
H57.1
ICD-10 Finland
Ocular pain
2.0
7.3
80
415
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.7
7.3
124
738
A32.1
ICD-10 Finland
Listerial meningitis and meningoencephalitis
+∞
7.3
7
*
B94.80
ICD-10 Finland
Late effects of bacterial meningitis
+∞
7.3
7
*
3202A
ICD-9 Finland
Bacterial meningitis, Streptococcal meningitis
+∞
7.3
7
*
9560/0-C72.4
ICD-O-3
Schwannoma, NOS, of acoustic nerve
9.4
7.3
14
15
Q07.0
ICD-10 Finland
Arnold-Chiari syndrome
9.4
7.3
14
15
M50.9
ICD-10 Finland
Cervical disc disorder, unspecified
4.2
7.3
19
46
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
2.3
7.2
50
216
J01MA14
ATC
moxifloxacin; systemic
1.6
7.2
153
966
AWC00
NOMESCO Finland
Reoperation of nervous system because of deep wound infection in the nervous system
30.1
7.1
9
*
N05BA01
ATC
diazepam; systemic, rectal
1.5
7.1
220
1515
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
3.0
7.0
29
96
G44.8
ICD-10 Finland
Other specified headache syndromes
2.7
7.0
35
129
AA1AA
NOMESCO Finland
Head X-ray examination
3.6
7.0
22
61
M03BX02
ATC
tizanidine; oral
1.3
7.0
1167
10397
A03FA01
ATC
metoclopramide; systemic, rectal
1.4
7.0
376
2866
J45.9
ICD-10 Finland
Asthma, unspecified
1.4
6.9
330
2464
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
3.0
6.9
29
97
3451A
ICD-9 Finland
Epilepsy, Generalised convulsive epilepsy
13.8
6.9
11
8
L04AA06
ATC
mycophenolic acid; systemic
2.6
6.9
39
154
J01MA01
ATC
ofloxacin; systemic
1.7
6.8
130
798
ZXA00
NOMESCO Finland
Right side
1.4
6.8
423
3298
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
6.8
481
3826
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
1.8
6.8
96
542
183
Kela drug reimbursment
Lamotrigin and topiramate
3.6
6.7
21
58
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
16.7
6.7
10
6
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
3.9
6.7
19
49
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
3.9
6.7
19
49
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.4
6.7
308
2287
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
22.6
6.7
9
*
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
2.4
6.6
43
181
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.5
6.6
243
1731
N03AX11
ATC
topiramate; oral
2.3
6.6
49
219
A40.8
ICD-10 Finland
Other streptococcal sepsis
3.6
6.6
21
59
G91.8
ICD-10 Finland
Other hydrocephalus
12.3
6.6
11
9
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
1.9
6.6
79
424
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
3.8
6.5
19
50
102
Kela drug reimbursment
Diabetes insipidus
10.0
6.5
12
12
R01AD08
ATC
fluticasone; nasal
1.3
6.5
505
4066
N05AH04
ATC
quetiapine; oral
1.4
6.5
321
2412
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
1.8
6.5
86
477
101
Kela drug reimbursment
Anterior pituitary hypofunction
3.5
6.4
21
60
AA5PD
NOMESCO Finland
CT examination of brain pefusion
3.5
6.4
21
60
M03AX01
ATC
botulinum toxin; parenteral
2.9
6.4
28
96
A84.9
ICD-10 Finland
Tick-borne viral encephalitis, unspecified
70.1
6.4
7
*
A84.8
ICD-10 Finland
Other tick-borne viral encephalitis
70.1
6.4
7
*
J01FA06
ATC
roxithromycin; oral
1.3
6.4
686
5763
J01MA12
ATC
levofloxacin; systemic
1.4
6.4
301
2242
R4110
NOMESCO Finland
Physiotherapy
1.3
6.4
471
3766
G50.0
ICD-10 Finland
Trigeminal neuralgia
2.5
6.4
38
154
B01AA03
ATC
warfarin; systemic
1.4
6.3
256
1856
N02CA01
ATC
dihydroergotamine; nasal, systemic
6.6
6.3
15
23
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
2.7
6.3
33
125
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.4
6.3
315
2373
I61.5
ICD-10 Finland
Intracerebral haemorrhage, intraventricular
18.1
6.3
9
5
AAF50
NOMESCO Finland
Third ventriculostomy
18.1
6.3
9
5
A89
ICD-10 Finland
Unspecified viral infection of central nervous system
+∞
6.3
6
*
G94.2
ICD-10 Finland
Hydrocephalus in other diseases classified elsewhere
+∞
6.3
6
*
N28
ICPC
Limited function/disability (N)
2.6
6.2
33
126
N18
ICPC
Paralysis/weakness
2.6
6.2
35
138
R60.0
ICD-10 Finland
Localized oedema
1.5
6.2
201
1397
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.4
6.2
234
1676
M54.1
ICD-10 Finland
Radiculopathy
1.9
6.2
73
390
Z3226
NOMESCO Finland
Physiotherapist
1.4
6.2
296
2213
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
5.7
6.1
16
28
ZXE20
NOMESCO Finland
More than three and less than five hours
1.5
6.1
215
1518
M03BX01
ATC
baclofen; systemic
2.4
6.1
39
163
A03
ICPC
Fever
1.4
6.1
313
2365
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.6
6.1
158
1047
N02AA05
ATC
oxycodone; systemic
1.4
6.1
281
2086
SPAT1153
SPAT
Removal of sutures
1.3
6.1
505
4100
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
12.6
6.1
10
8
120
Kela drug reimbursment
Hypogammaglobulinaemia
12.6
6.1
10
8
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
3.1
6.0
24
78
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
3.6
6.0
19
53
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.5
6.0
160
1066
Z3229
NOMESCO Finland
Other healthcare associate professional
1.6
6.0
132
841
N07BA03
ATC
varenicline; oral
1.8
6.0
92
533

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
378
424
10.70
316.75
1.9
1.4
1050.80
1064.02
e6/l
0.01
294
332
372
417
10.68
311.70
1.9
1.4
417.39
22.81
e6/l
5.28
284
306
341
164
24.74
307.65
2.0
1.6
—
—
—
0
0
436
419
12.94
307.65
1.8
1.2
3.25
3.76
mmol/l
9.42
412
398
391
380
12.48
307.65
1.9
1.4
—
—
—
0
0
458
475
12.13
307.65
1.9
1.2
1127.50
497.28
mg/l
20.10
446
453
197
135
16.03
223.73
2.0
1.2
3.78
1.90
mmol/l
9.60
188
126
203
208
10.72
179.07
1.3
1.0
51.67
—
au/ml
—
6
0
184
178
11.26
168.78
1.1
1.0
—
—
—
0
0
125
66
20.10
160.74
1.2
1.1
498.60
32.54
ng/l
2.23
66
13
179
199
9.76
148.34
1.6
1.6
—
—
—
0
0
98
83
12.35
97.52
1.9
1.1
52.11
56.00
%
—
57
7
56
22
26.14
80.57
2.0
1.2
54.98
38.00
%
—
48
6
362
1292
3.19
77.76
2.9
2.5
29.11
21.65
au/ml
0.73
32
157
343
1188
3.27
77.45
1.6
1.3
57.34
42.76
au/ml
0.64
26
90
67
51
13.54
70.96
1.6
1.1
29.42
30.60
%
—
48
5
125
240
5.48
62.32
5.1
6.5
10.92
11.53
mg/l
0.61
116
220
792
4672
2.13
56.41
5.1
4.3
—
—
—
0
0
69
98
7.25
46.31
1.2
1.2
—
—
—
0
0
80
158
5.23
38.56
1.2
1.1
91.67
40.58
mg/l
4.12
70
125
310
1483
2.28
35.35
3.9
2.8
10.12
10.65
g/l
1.53
299
1368
73
152
4.94
33.12
1.1
1.1
551.61
266.70
mg/l
3.00
64
128
780
5379
1.73
29.43
2.7
2.2
166.70
227.22
u/l
1.36
755
5110
32
33
9.83
27.69
1.1
1.0
14.95
7.80
mg/g
1.78
32
33
68
155
4.50
27.68
1.9
2.3
1336.21
1294.60
e6/l
0.12
56
136
445
2662
1.86
26.87
2.1
2.2
29.21
29.53
s
0.42
434
2587
55
111
5.06
25.89
1.7
2.5
521.79
582.11
e6/l
0.24
42
90
58
123
4.82
25.77
1.2
1.2
0.87
0.55
ratio
1.01
27
70
54
113
4.88
24.38
1.8
2.5
202.54
214.44
e6/l
0.15
41
97
1177
9327
1.61
24.07
7.5
6.6
10.55
11.45
umol/l
2.01
1128
8930
31
37
8.49
24.03
1.1
1.0
—
—
—
0
0
1272
10319
1.61
23.19
6.4
5.3
6.61
6.64
mmol/l
0.23
1222
9762
1170
9311
1.60
23.06
8.2
6.5
0.58
0.57
e9/l
0.43
1032
8061
1015
7813
1.59
23.05
14.5
13.5
1.20
1.22
inr
0.54
875
6507
414
2535
1.79
22.75
2.0
2.1
—
—
—
0
0
1169
9319
1.59
22.73
8.2
6.5
0.04
0.04
e9/l
0.08
1029
8066
826
6094
1.59
22.20
8.4
6.5
—
—
—
0
0
1196
9621
1.58
22.07
8.4
6.7
0.20
0.19
e9/l
0.51
1062
8452
1098
8664
1.58
22.00
8.9
7.4
1.21
1.21
mmol/l
1.41
964
7527
1083
8546
1.57
21.49
8.5
6.7
2.84
2.85
%
0.05
1031
8063
34
52
6.63
21.31
1.4
1.3
—
—
—
0
0
1268
10385
1.58
21.27
11.4
9.7
4.26
4.07
e9/l
1.79
1127
9067
1181
9527
1.56
21.08
8.2
6.5
2.05
1.95
e9/l
0.65
1065
8448
1078
8529
1.56
20.91
8.7
6.8
0.66
0.69
%
0.78
1026
8040
135
563
2.50
20.68
3.0
1.6
0.22
0.24
g/l
1.22
125
535
1079
8561
1.55
20.50
8.7
6.8
8.62
8.75
%
0.78
1027
8082
226
1172
2.04
20.47
2.2
1.8
1.62
1.33
g/l
0.46
209
1085
997
7780
1.55
20.38
8.1
6.8
1.20
1.21
mmol/l
2.86
935
7221
1101
8791
1.54
20.20
8.5
6.6
28.38
28.12
%
0.32
1058
8393
1081
8657
1.53
19.13
8.2
6.5
56.53
57.04
%
0.72
1042
8311
135
584
2.40
19.09
3.0
1.6
1.19
1.21
g/l
0.16
125
552
855
6538
1.53
18.62
3.8
3.6
22.86
52.73
ng/l
2.11
574
4381
984
7767
1.51
18.36
5.9
5.2
35.54
36.12
g/l
2.31
935
7330
759
5688
1.53
17.99
2.8
2.7
61.60
74.03
u/l
0.37
710
5302
324
1980
1.76
17.55
9.6
9.2
7.42
7.41
ph
0.64
190
1110
321
1972
1.74
17.04
9.5
9.1
1.14
0.95
mmol/l
0.42
275
1623
319
1985
1.72
16.11
9.7
9.2
5.08
5.12
kpa
0.28
309
1913
319
1985
1.72
16.11
9.6
9.1
12.63
12.33
kpa
0.48
309
1915
288
1775
1.72
15.00
10.0
9.6
95.72
95.60
%
0.10
278
1719
60
193
3.17
15.00
1.5
1.3
—
—
—
0
0
75
276
2.78
14.79
1.2
1.2
—
—
—
0
0
331
2143
1.65
14.28
2.0
1.7
—
—
—
0
0
1526
13529
1.50
13.88
10.7
8.2
77.97
78.28
u/l
0.11
1480
12896
78
307
2.60
13.52
1.3
1.4
73.11
62.49
mmol/l
1.03
61
255
58
195
3.03
13.48
1.5
1.3
6.05
6.77
g/l
1.06
45
144
58
195
3.03
13.48
1.5
1.3
0.32
0.39
g/l
0.97
45
143
58
195
3.03
13.48
1.5
1.3
2.60
3.06
g/l
1.77
45
143
42
116
3.67
13.31
1.3
1.1
1803.60
1556.04
miu/ml
0.60
42
116
81
328
2.53
13.25
1.9
1.7
0.69
0.84
g/l
0.67
66
263
266
1663
1.69
13.07
11.0
10.0
120.22
122.49
g/l
1.00
260
1627
1478
13119
1.45
12.50
5.6
4.3
11.91
11.25
mm/h
1.07
1418
12367
132
675
2.02
12.37
2.6
2.0
0.96
1.84
ug/l
1.03
118
603
25
49
5.15
12.21
1.4
2.0
0.22
0.21
e9/l
0.06
11
23
108
515
2.16
12.18
2.3
2.3
11.19
11.54
mg/l
0.19
103
483
421
2986
1.52
12.09
3.9
3.7
0.82
0.82
mmol/l
0.08
404
2839
595
4536
1.44
11.81
4.7
4.2
91.27
91.04
%
0.08
583
4442
653
5073
1.42
11.64
3.9
3.0
—
—
—
0
0
1307
11418
1.40
11.54
6.4
4.5
2527.04
1791.51
e6/l
0.14
25
164
172
984
1.82
11.51
10.7
12.4
16.03
16.07
%
0.05
166
949
547
4159
1.43
10.86
1.7
1.8
1.15
1.12
mg/l
0.09
419
3175
342
2371
1.53
10.83
6.7
6.2
1.01
1.04
mmol/l
0.91
328
2209
446
3315
1.44
9.90
3.9
3.8
169.36
464.98
ng/l
3.21
307
2472
176
1061
1.72
9.84
10.2
7.4
25.04
24.49
mmol/l
1.43
168
1016
511
3904
1.41
9.71
1.7
1.5
2.31
2.37
g/l
0.31
354
2483
447
3337
1.43
9.66
3.7
2.9
525.10
533.31
mosm/kgh2o
0.33
408
2930
115
618
1.91
9.39
2.5
2.4
669.98
414.96
ug/l
0.39
106
588
52
204
2.59
9.17
1.5
1.6
284.98
279.98
mosm/kgh2o
0.88
41
152
705
5725
1.35
9.11
4.4
3.3
27.28
71.65
e6/l
2.42
554
4347
371
2703
1.45
9.09
1.4
1.4
669.27
492.75
titre
0.84
82
574
263
1787
1.54
9.06
3.6
3.8
7.38
7.38
ph
0.51
148
1015
239
1595
1.56
8.92
8.0
7.8
8.37
9.14
mmol/l
1.16
233
1534
411
3064
1.43
8.88
3.4
2.9
1.19
1.22
e6/l
0.03
203
1593
98
509
1.97
8.85
9.3
7.6
1.27
1.30
mmol/l
0.13
86
447
705
5748
1.34
8.80
2.7
2.4
—
—
—
0
0
261
1785
1.53
8.72
3.5
3.8
5.75
5.83
kpa
0.70
256
1734
903
7642
1.32
8.69
4.4
3.4
6.21
6.21
ph
0.02
526
4405
137
798
1.77
8.65
3.1
1.9
4.73
7.54
iu/ml
1.18
48
189
1095
9533
1.32
8.56
4.9
3.8
6.20
5.06
estimate
0.06
219
1994
58
248
2.38
8.55
1.4
1.5
—
—
—
0
0
58
248
2.38
8.55
1.4
1.5
—
—
—
0
0
58
248
2.38
8.55
1.4
1.5
—
—
—
0
0
58
248
2.38
8.55
1.4
1.5
—
—
—
0
0
267
1845
1.51
8.49
2.8
2.2
360.58
377.33
nmol/l
0.61
253
1717
24
63
3.84
8.24
2.0
1.7
27.08
29.51
%
0.30
24
63
379
2825
1.42
8.13
3.6
3.0
2.85
2.52
e6/l
0.31
168
1351
74
358
2.11
8.13
10.6
9.3
10.81
11.33
mmol/l
0.70
67
323
74
359
2.10
8.08
10.6
9.3
105.03
105.34
mmol/l
0.21
67
324
1081
9443
1.31
8.02
5.0
3.8
0.00
0.00
estimate
0.50
212
1961
11
5
22.10
8.01
1.1
1.0
—
—
—
0
0
1095
9589
1.30
7.94
5.0
3.8
0.00
0.17
estimate
0.55
208
1859
224
1516
1.54
7.84
3.2
3.1
4.59
4.62
kpa
0.08
218
1470
610
4936
1.34
7.82
4.2
3.2
0.25
0.40
e6/l
1.95
455
3575
892
7618
1.30
7.73
2.2
2.1
99.45
96.58
pmol/l
0.85
482
4114
248
1729
1.49
7.54
3.9
3.8
1.69
1.83
mmol/l
0.26
226
1483
960
8297
1.29
7.54
3.0
2.8
—
—
estimate
—
0
0
129
771
1.72
7.47
1.7
1.4
18.24
11.92
iu/ml
—
5
25
784
6605
1.30
7.44
5.4
3.9
38.21
95.52
e6/l
3.54
572
4606
15
18
8.38
7.31
1.1
2.4
—
—
—
0
0
483
3810
1.35
7.26
2.1
2.0
—
—
—
0
0
497
3940
1.34
7.23
3.7
2.7
5.72
5.84
e6/l
0.06
469
3596
119
703
1.74
7.20
8.4
6.3
0.91
0.88
%
0.41
113
661
224
1554
1.50
6.97
9.6
10.0
—
—
—
0
0
223
1564
1.48
6.57
4.5
4.1
7.38
7.35
ph
3.58
171
1143
1382
12627
1.29
6.57
4.0
3.4
52.13
47.03
u/l
1.20
1331
12003
124
763
1.67
6.48
8.2
6.0
1.80
1.60
%
1.22
118
722
40
167
2.42
6.29
3.8
4.1
—
—
—
0
0
261
1904
1.42
6.25
2.7
2.8
1.78
1.79
%
0.04
237
1727
206
1439
1.48
6.20
2.6
2.9
69.79
71.18
e9/l
0.17
155
1052
124
773
1.64
6.17
1.5
1.2
0.26
1.01
u/ml
—
9
58
932
8156
1.26
6.16
2.9
2.5
76.22
76.35
nmol/l
0.05
855
7446
110
666
1.69
6.12
1.3
1.2
—
—
—
0
0
236
1705
1.43
5.96
2.3
2.4
0.22
0.22
g/l
0.32
224
1598
54
263
2.08
5.92
4.6
3.6
0.95
1.60
%
0.91
49
240
231
1665
1.44
5.91
2.3
2.1
0.00
0.01
estimate
0.78
48
353
147
970
1.55
5.79
1.3
1.2
—
—
—
0
0
513
4199
1.30
5.77
4.9
3.8
1.02
1.38
kg/l
0.50
347
2791
127
813
1.60
5.70
4.9
3.9
—
—
—
0
0
119
751
1.62
5.66
1.6
1.9
1.61
1.54
g/l
0.32
106
666
307
2340
1.37
5.66
3.6
3.3
5.36
4.86
e9/l
0.17
249
2071
580
4835
1.28
5.64
3.0
3.2
1196.38
1182.00
ng/l
0.02
494
4101
294
2234
1.37
5.52
1.7
1.5
—
—
—
0
0
529
4370
1.28
5.51
2.7
2.4
—
—
—
0
0
223
1618
1.42
5.50
4.7
4.7
0.74
0.97
%
0.84
88
479
189
1330
1.46
5.49
1.5
1.3
181.34
225.38
u/ml
0.36
181
1235
64
343
1.89
5.39
1.2
1.1
22.14
17.94
au/ml
—
7
96
615
5187
1.26
5.39
4.9
4.2
7.40
7.40
ph
1.02
445
3709
38
167
2.30
5.38
4.4
3.6
53.26
55.71
%
0.29
33
151
642
5445
1.26
5.36
6.7
6.2
—
—
—
0
0
213
1541
1.43
5.34
4.6
4.5
0.59
0.67
%
0.28
89
448
170
1179
1.48
5.32
4.9
3.6
5.14
5.15
kpa
0.07
164
1142
640
7443
0.80
5.30
2.9
3.0
—
—
—
0
0
33
138
2.41
5.22
1.3
1.1
—
—
—
0
0
130
855
1.56
5.22
2.5
2.2
0.03
0.97
estimate
0.49
39
263
196
1410
1.43
5.08
2.8
2.8
66.16
66.84
g/l
0.60
181
1318
238
1772
1.39
5.06
2.6
2.4
47.64
67.18
u/l
0.29
204
1496
141
951
1.52
5.06
2.7
2.7
1.21
1.25
%
0.21
141
944
30
122
2.48
5.04
1.1
1.0
230.32
290.57
ng/l
0.72
19
83
30
122
2.48
5.04
1.1
1.0
657.76
757.17
ng/l
0.58
21
82
729
6311
1.24
5.00
3.8
3.4
33.18
32.54
u/l
0.18
693
5984
91
555
1.67
4.99
1.6
1.3
5.12
8.78
u/ml
0.45
18
80
40
186
2.17
4.98
2.2
6.4
7.54
7.01
mmol/l
0.18
28
157
95
588
1.65
4.92
1.5
1.2
37.55
24.95
u/ml
—
10
29
164
1148
1.47
4.91
5.0
3.7
7.41
7.42
ph
0.25
133
969
1819
17450
1.38
4.91
23.3
15.1
23.72
23.26
mg/l
0.25
1602
14310
609
5182
1.25
4.85
5.3
3.9
0.00
0.00
estimate
1.54
197
1838
823
7236
1.23
4.84
4.9
3.6
0.01
0.09
estimate
0.74
169
1646
343
2725
1.31
4.75
1.9
1.7
1174.09
1183.13
nmol/l
0.07
271
2088
575
4875
1.25
4.71
1.7
1.7
20.79
20.39
nmol/l
0.26
496
4178
803
7065
1.22
4.64
2.2
2.1
—
—
—
0
0
87
537
1.65
4.58
1.4
1.5
270.15
282.76
ug/g
0.22
48
306
272
2106
1.34
4.51
2.7
2.9
7.64
7.59
umol/l
0.01
233
1855
209
1553
1.38
4.51
4.8
4.7
0.13
0.12
%
0.08
76
413
39
188
2.09
4.47
1.1
1.1
—
—
—
0
0
136
936
1.48
4.46
2.6
2.7
0.66
0.62
%
0.79
136
931
34
156
2.20
4.40
1.1
1.2
—
—
—
0
0
85
528
1.64
4.38
2.1
1.8
—
—
—
0
0
550
4674
1.24
4.36
2.9
2.7
337.77
340.33
umol/l
0.26
495
4182
430
3555
1.26
4.34
1.6
1.7
56364075.08
34387912.20
pmol/l
0.22
385
3004
88
554
1.61
4.30
1.6
1.2
7.26
2.45
u/ml
0.68
13
45
71
424
1.70
4.25
4.5
3.4
56.31
58.25
%
0.58
71
424
69
410
1.71
4.21
2.4
2.2
130.42
130.32
g/l
0.01
48
331
68
403
1.71
4.19
1.6
1.4
—
—
—
0
0
209
1573
1.37
4.18
5.2
4.9
0.07
0.33
%
0.66
75
379
293
2322
1.31
4.12
1.8
1.6
—
—
—
0
0
101
665
1.55
4.10
1.3
1.3
—
—
—
0
0
51
280
1.84
4.07
4.7
6.1
363.28
368.09
umol/l
0.09
43
249
974
8810
1.20
4.05
3.4
3.1
114.51
118.39
ug/l
0.27
922
8302
895
8040
1.20
3.99
13.8
11.2
0.00
0.00
e9/l
0.95
726
6590
541
4633
1.23
3.94
2.5
2.3
2.82
2.79
mg/l
0.09
481
3997
12
27
4.46
3.93
1.0
1.1
—
—
—
0
0
57
328
1.76
3.91
1.7
2.1
4.41
5.18
mmol/24h
0.87
48
292
189
1418
1.37
3.87
3.2
2.4
0.22
0.46
e6/l
1.80
176
1352
83
531
1.59
3.83
1.1
1.1
—
—
—
0
0
98
653
1.53
3.79
4.7
4.0
24.71
24.84
mmol/l
0.19
91
610
502
4287
1.23
3.74
6.1
4.8
—
—
—
0
0
57
333
1.73
3.73
4.8
3.6
3.78
4.19
e9/l
0.65
57
333
189
1427
1.36
3.72
2.6
2.4
6.04
6.09
ph
0.35
123
941
114
789
1.47
3.68
6.2
4.4
36.91
36.92
°c
0.16
114
782
335
2747
1.26
3.60
2.9
2.6
2.32
2.33
g/l
0.17
321
2562
62
375
1.67
3.59
1.5
1.4
166.21
155.14
au/ml
0.33
19
108
255
2025
1.30
3.54
1.7
1.8
—
—
—
0
0
31
151
2.07
3.52
1.3
1.5
1.02
1.23
promille
0.34
25
123
1468
13875
1.20
3.49
4.8
4.4
14.70
14.70
pmol/l
0.02
1368
12888
599
5237
1.20
3.48
3.6
2.9
0.00
0.03
0.74
11
104
306
2497
1.26
3.42
2.7
2.6
132.80
125.39
ug/g
0.19
244
2006
12
33
3.65
3.29
1.1
1.2
—
—
—
0
0
153
1143
1.37
3.25
3.2
3.5
4.50
4.55
pmol/l
0.25
131
1017
40
220
1.83
3.24
1.5
1.3
—
—
—
0
0
355
2969
1.24
3.19
2.9
2.6
12.91
13.50
umol/l
0.70
342
2784
103
722
1.45
3.16
2.0
2.3
20.16
20.75
s
0.93
88
644
1817
17612
1.28
3.09
24.6
17.4
139.47
139.67
mmol/l
2.81
1806
17295
16
63
2.55
2.95
3.3
2.9
30.44
31.15
umol/l
—
10
49
105
753
1.42
2.87
1.3
1.2
—
—
—
0
0
304
2533
1.23
2.83
3.0
2.6
22.32
23.32
%
0.54
293
2377
22
103
2.15
2.80
1.2
1.3
118.50
142.74
nmol/l
1.74
22
103
71
474
1.52
2.80
1.4
1.2
—
—
—
0
0
29
151
1.93
2.80
1.1
1.1
105.97
108.71
pmol/l
0.14
29
151
16
65
2.47
2.79
2.1
2.0
85.77
65.13
ug/l
0.32
16
65
68
451
1.52
2.77
3.1
3.3
5.63
1.96
index
0.59
32
231
42
247
1.71
2.76
1.2
1.6
31.63
29.93
ng/l
0.06
42
247
5
6
8.35
2.75
1.6
1.0
—
—
—
0
0
82
571
1.45
2.65
2.7
2.4
9.73
10.35
g/l
0.55
72
522
1816
17655
1.25
2.63
24.7
17.5
3.96
3.96
mmol/l
0.60
1801
17303
9
25
3.61
2.57
2.4
1.6
—
—
—
0
0
53
339
1.58
2.55
8.3
4.0
2.60
2.55
mmol/l
0.04
28
224
101
738
1.39
2.52
1.1
1.1
—
—
—
0
0
10
31
3.24
2.51
2.4
2.0
—
—
—
0
0
174
1379
1.29
2.50
2.3
2.3
5.81
7.63
ug/l
0.93
148
1241
67
455
1.49
2.47
1.5
1.2
24.05
51.53
u/ml
1.67
14
47
57
374
1.54
2.47
6.4
3.4
—
—
—
0
0
674
6099
1.16
2.45
3.9
3.5
2.35
2.35
mmol/l
0.91
615
5594
65
443
1.48
2.37
1.7
1.6
12778.92
11280.51
e6/l
0.18
51
317
169
1346
1.28
2.35
4.3
4.1
77.33
84.86
ng/l
0.80
149
1188
379
3286
1.19
2.35
1.4
1.3
8.33
11.02
u/ml
0.45
153
1309
364
3145
1.19
2.34
1.8
1.7
—
—
—
0
0
57
838
0.67
2.34
1.1
1.1
1.54
1.52
g/l
0.16
57
838
294
2504
1.20
2.22
1.2
1.2
—
—
—
0
0
270
2281
1.21
2.22
1.5
1.5
—
—
—
0
0
586
5283
1.15
2.21
4.4
3.2
0.06
0.23
estimate
0.49
168
1577
185
1503
1.25
2.20
1.4
1.4
—
—
—
0
0
243
2034
1.22
2.19
5.0
4.8
32.31
31.67
%
0.35
159
1399
30
173
1.74
2.17
3.0
2.7
—
—
—
0
0
54
789
0.68
2.17
1.1
1.1
0.70
0.65
ratio
—
6
84
11
42
2.63
2.14
2.5
3.5
—
—
—
0
0
85
624
1.38
2.11
4.5
3.5
236.87
276.47
mg/l
0.35
38
291
32
190
1.69
2.10
1.4
1.8
53.14
58.01
%
0.24
22
130
61
865
0.70
2.09
1.1
1.2
0.86
0.90
g/l
0.77
61
865
59
407
1.46
2.06
1.4
1.3
243.03
250.02
u/ml
0.08
36
248
152
1218
1.27
2.04
2.9
3.0
162.12
192.79
ng/l
0.49
131
1111
117
907
1.31
2.03
1.7
1.7
0.35
0.32
mg/l
0.17
65
435
189
1556
1.24
2.01
1.5
1.5
—
—
—
0
0
17
83
2.06
2.01
1.2
1.3
7.29
7.40
ph
0.73
12
59
69
494
1.41
1.99
2.8
3.4
1.64
3.09
ratio
0.83
42
271
107
823
1.32
1.97
4.0
3.3
1.02
1.02
ratio
0.76
96
759
48
321
1.51
1.96
1.2
1.3
—
9.43
—
0
7
89
667
1.35
1.96
1.3
1.3
159.80
224.15
miu/ml
1.40
43
313
37
234
1.59
1.93
2.4
2.3
7.62
6.14
umol/l
0.33
25
171
9
33
2.73
1.93
1.3
1.0
—
—
—
0
0
9
33
2.73
1.93
1.3
1.0
—
—
—
0
0
9
33
2.73
1.93
1.3
1.0
—
—
—
0
0
58
405
1.44
1.92
3.6
2.9
1.50
1.58
mmol/l
0.30
58
391
142
1142
1.26
1.87
3.1
2.4
—
—
—
0
0
630
5767
1.13
1.85
3.8
3.5
—
0.74
—
0
19
17
86
1.98
1.85
1.7
1.9
—
—
—
0
0
51
351
1.46
1.83
1.8
1.6
—
—
—
0
0
99
763
1.31
1.82
2.0
1.6
323.37
291.60
mu/l
0.32
92
699
496
4483
1.14
1.77
1.3
1.3
1.79
1.63
u/ml
0.07
132
1268
202
1700
1.21
1.76
4.3
4.4
15.70
17.65
ug/l
0.08
154
1386
9
36
2.51
1.74
1.8
1.7
—
—
—
0
0
74
551
1.36
1.73
3.2
3.6
32.80
49.02
mg/l
1.22
62
460
84
639
1.33
1.71
4.2
3.6
389.65
2415.75
u/ml
0.70
74
551
55
392
1.41
1.67
1.2
1.1
—
—
—
0
0
55
392
1.41
1.67
1.2
1.1
—
—
—
0
0
25
149
1.69
1.67
3.4
3.4
14.31
12.60
index
0.56
16
89
6
19
3.16
1.66
1.5
1.2
—
—
—
0
0
48
335
1.44
1.64
1.1
1.1
—
—
—
0
0
43
294
1.47
1.63
1.2
1.2
—
—
—
0
0
162
1346
1.22
1.62
5.4
3.8
1.21
1.23
mmol/l
2.69
147
1158
70
523
1.35
1.62
7.4
9.6
—
—
—
0
0
12
56
2.15
1.61
1.2
1.1
—
—
—
0
0
32
206
1.56
1.59
3.0
2.5
1.56
1.42
g/24h
0.08
16
128
73
551
1.34
1.58
3.2
3.6
39.46
57.14
mg/l
0.83
61
459
7
26
2.70
1.58
2.1
3.8
44.86
44.12
umol/l
—
7
21
36
239
1.51
1.57
3.3
3.0
—
—
—
0
0
15
78
1.93
1.54
35.7
30.8
96.17
128.57
ug/l
1.95
15
61
179
1514
1.20
1.51
1.2
1.2
—
—
—
0
0
74
567
1.32
1.47
1.1
1.3
90.00
95.08
titre
—
5
59
21
124
1.70
1.47
2.7
2.8
42.57
42.37
%
0.02
13
60
24
148
1.63
1.44
1.2
1.3
—
—
—
0
0
91
720
1.28
1.43
1.6
2.1
—
—
—
0
0
47
339
1.40
1.38
1.1
1.1
—
—
—
0
0
16
89
1.80
1.37
4.1
4.0
0.63
0.90
index
1.17
16
89
65
495
1.32
1.36
1.3
1.2
—
—
—
0
0
47
340
1.39
1.36
3.3
3.8
110.67
1186.42
u/ml
0.84
42
325
44
315
1.41
1.35
1.3
1.2
7.70
4.59
u/ml
0.54
20
135
239
2095
1.16
1.34
1.6
1.4
—
—
—
0
0
10
47
2.13
1.33
2.2
2.0
19.46
16.99
umol/l
—
10
47
22
136
1.62
1.32
2.4
2.9
97.78
13.01
mg/l
0.95
17
99
391
3549
1.13
1.31
1.5
1.3
23.03
28.69
iu/ml
0.57
123
1086
650
6066
1.10
1.31
3.7
3.5
7.75
7.84
mmol/l
0.16
557
5231
96
778
1.25
1.26
2.0
1.9
—
—
—
0
0
25
162
1.55
1.26
1.3
1.4
60477.00
148494.96
e6/l
0.66
16
82
1666
16285
1.12
1.25
5.9
5.3
1.82
1.86
mu/l
0.63
1572
15238
159
1357
1.19
1.25
1.2
1.2
93.61
141.79
u/ml
1.11
61
521
1872
18441
1.17
1.24
15.5
11.7
27.76
26.98
u/l
0.78
1837
18003
13
70
1.86
1.24
2.4
1.5
—
—
—
0
0
5
19
2.63
1.21
1.4
1.2
—
—
—
0
0
25
164
1.53
1.20
1.4
1.4
—
—
—
0
0
93
757
1.24
1.19
2.5
2.2
2317.61
5890.56
u/l
1.72
36
304
1880
18534
1.17
1.19
26.6
19.1
75.50
76.11
umol/l
0.37
1872
18361
8
38
2.11
1.18
1.4
1.4
—
—
—
0
0
25
165
1.52
1.17
1.3
1.3
120135.05
145228.20
e6/l
0.07
19
112
196
1713
1.16
1.17
2.6
2.4
12.83
13.39
nmol/l
0.45
174
1571
5
20
2.50
1.15
1.2
1.2
—
—
—
0
0
80
646
1.25
1.11
1.8
1.4
11.10
9.03
u/l
0.56
67
521
23
151
1.53
1.11
1.1
1.1
—
—
—
0
0
5
21
2.38
1.09
7.2
9.7
3.66
6.06
mmol/l
—
5
21
24
161
1.50
1.06
1.3
1.3
—
—
—
0
0
27
187
1.45
1.03
1.3
1.3
3219.86
1972.72
e6/l
0.38
21
123
5
22
2.28
1.03
2.0
1.2
—
122.61
—
0
7
7
34
2.06
1.03
1.4
1.3
67.71
69.29
ug/l
—
7
34
7
34
2.06
1.03
33.7
7.1
6.47
5.20
kpa
—
7
34
31
221
1.41
1.02
2.5
2.9
—
—
—
0
0
172
1956
0.87
1.02
1.4
1.4
—
—
—
0
0
14
83
1.69
1.01
1.1
1.2
—
—
—
0
0
10
53
1.89
1.01
1.0
1.1
—
—
—
0
0
10
53
1.89
1.01
1.0
1.1
—
—
—
0
0
10
53
1.89
1.01
1.0
1.1
—
—
—
0
0
219
1955
1.13
0.99
1.6
1.5
—
—
—
0
0
14
84
1.67
0.97
2.3
2.3
1.86
1.98
ug/l
—
9
74
21
140
1.50
0.97
2.4
2.4
25.89
31.94
mg/l
0.22
13
96
21
140
1.50
0.97
1.1
1.1
—
—
—
0
0
0
30
0.00
0.97
0.0
2.2
—
—
—
0
0
7
36
1.95
0.97
2.1
1.9
—
—
—
0
0
35
258
1.36
0.97
1.7
1.6
328.85
329.22
mu/l
0.00
26
209
86
715
1.21
0.95
1.7
1.7
4.19
13.72
u/ml
3.81
16
176
21
141
1.49
0.94
1.6
1.6
27.93
32.87
%
0.24
15
93
11
62
1.78
0.94
4.8
2.8
—
—
—
0
0
44
338
1.31
0.94
3.8
3.0
7.78
7.42
mmol/l
0.28
44
327
6
27
2.23
0.93
1.2
1.0
—
—
—
0
0
77
635
1.22
0.92
2.5
2.9
—
—
—
0
0
203
2264
0.89
0.91
1.9
2.0
3.68
3.56
ratio
0.52
150
1753
99
838
1.19
0.91
1.6
2.2
—
—
—
0
0
370
3423
1.10
0.89
3.3
3.0
2.44
2.44
mmol/l
0.07
334
3086
8
43
1.86
0.87
1.5
1.8
—
—
—
0
0
18
120
1.50
0.85
1.2
1.5
8.55
6.38
u/l
0.26
13
98
98
836
1.18
0.84
2.5
2.3
—
—
—
0
0
21
146
1.44
0.82
1.0
1.1
—
—
—
0
0
38
294
1.30
0.80
1.4
1.3
22.56
24.50
u/l
0.17
32
238
12
74
1.62
0.78
5.6
2.9
0.81
1.29
ug/l
0.74
12
69
12
74
1.62
0.78
4.6
2.6
—
—
—
0
0
48
385
1.25
0.77
2.1
2.8
—
—
—
0
0
47
377
1.25
0.76
4.9
4.4
—
—
—
0
0
10
59
1.70
0.75
1.0
1.1
—
—
—
0
0
13
197
0.66
0.75
1.0
1.1
—
—
—
0
0
7
38
1.84
0.73
3.6
3.3
—
—
—
0
0
5
25
2.00
0.72
1.0
1.4
—
—
—
0
0
1665
16392
1.08
0.72
6.4
6.0
39.08
38.87
mmol/mol
0.43
1577
15485
48
389
1.24
0.72
1.4
1.2
—
—
—
0
0
11
68
1.62
0.71
3.1
1.5
39.13
40.75
g/l
0.59
11
68
23
168
1.37
0.71
2.4
2.0
—
—
—
0
0
22
160
1.38
0.70
1.6
1.6
—
—
—
0
0
5
27
1.85
0.68
1.6
1.6
—
—
—
0
0
7
42
1.67
0.68
1.0
1.2
—
—
—
0
0
9
59
1.53
0.68
1.0
1.0
—
—
—
0
0
69
586
1.18
0.66
2.3
2.6
—
—
—
0
0
43
349
1.24
0.65
1.6
1.4
0.31
0.36
nmol/l
0.31
30
279
224
2063
1.10
0.63
1.6
1.7
—
—
—
0
0
102
898
1.14
0.63
1.6
2.0
—
—
—
0
0
13
87
1.50
0.63
1.0
1.1
—
—
—
0
0
154
1698
0.90
0.62
1.6
1.7
3.56
3.49
mmol/l
0.26
100
1190
34
272
1.25
0.59
1.2
1.6
—
—
—
0
0
18
131
1.38
0.59
1.1
1.2
—
—
—
0
0
102
906
1.13
0.57
1.6
2.1
—
—
—
0
0
103
916
1.13
0.56
1.6
2.1
—
—
—
0
0
102
911
1.13
0.53
1.6
2.1
—
—
—
0
0
36
295
1.22
0.53
1.2
1.2
—
—
—
0
0
249
2328
1.08
0.52
1.3
1.3
—
—
—
0
0
50
425
1.18
0.51
1.2
1.3
—
—
—
0
0
574
5519
1.06
0.51
3.8
3.6
80.14
48.61
mg/l
1.38
370
3576
39
324
1.21
0.51
1.2
1.1
106.56
141.09
iu/ml
—
9
74
7
107
0.65
0.48
2.0
1.7
78.00
101.98
ng/l
—
7
107
104
937
1.12
0.48
1.1
1.1
—
0.91
—
0
10
7
46
1.52
0.48
1.1
1.2
295.14
282.13
pmol/l
—
7
30
48
410
1.17
0.47
1.9
2.2
0.91
0.91
nmol/l
0.00
40
354
1486
15061
0.95
0.47
26.0
19.0
332.83
332.80
g/l
0.05
1476
14979
37
310
1.20
0.45
2.3
1.8
—
—
—
0
0
13
175
0.74
0.44
1.2
1.1
—
—
—
0
0
13
95
1.37
0.43
48.0
40.9
6.58
7.43
ug/l
1.40
13
85
34
285
1.20
0.42
1.2
1.1
2.18
2.43
eliau/ml
0.09
12
130
18
140
1.29
0.42
1.1
1.1
8.62
8.75
iu/ml
—
5
36
10
70
1.43
0.41
1.5
1.6
0.30
0.04
estimate
—
10
70
0
16
0.00
0.41
0.0
1.1
—
0.15
—
0
8
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
0.18
—
0
9
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
11
79
1.39
0.40
2.4
3.5
12.10
8.89
mg/l
0.71
11
70
60
530
1.14
0.40
1.1
1.1
—
—
—
0
0
5
34
1.47
0.40
1.2
1.3
—
191.33
—
0
6
19
150
1.27
0.40
1.1
1.1
10.76
14.97
u/ml
—
8
64
579
5614
1.04
0.37
4.5
4.3
14.95
8.79
mg/mmol
1.23
368
3555
9
69
1.31
0.37
6.6
4.5
—
—
—
0
0
63
565
1.12
0.35
2.0
2.0
202.89
206.16
pmol/l
0.08
63
538
6
43
1.40
0.35
1.3
1.3
91.15
65.84
mu/l
—
6
33
6
43
1.40
0.35
4.2
3.2
6.00
5.44
ug/l
—
6
43
52
461
1.13
0.35
1.1
1.1
1.79
2.67
u/ml
0.45
31
255
15
118
1.27
0.33
1.0
1.0
—
—
—
0
0
31
359
0.86
0.32
1.9
1.6
—
—
—
0
0
26
220
1.18
0.31
2.2
2.3
—
—
—
0
0
542
5274
1.04
0.30
5.4
5.0
2.42
2.21
ug/l
0.16
501
4797
11
84
1.31
0.30
1.6
1.4
125.31
172.60
mmol/24h
1.57
11
84
11
141
0.78
0.29
1.3
1.5
—
—
—
0
0
43
383
1.13
0.28
1.4
1.4
1.36
1.29
mm
0.50
31
268
83
895
0.92
0.27
1.6
1.6
974.25
991.58
mu/l
0.05
68
740
113
1064
1.07
0.25
1.6
1.4
25.34
25.46
iu/l
0.01
98
910
10
126
0.79
0.24
2.0
1.7
7.36
7.74
mmol/l
—
10
121
5
38
1.32
0.23
3.4
4.0
127.60
69.25
ng/l
—
5
21
13
106
1.23
0.23
1.3
1.3
—
—
—
0
0
11
88
1.25
0.22
2.2
1.6
—
—
—
0
0
5
41
1.22
0.22
1.0
1.0
—
—
—
0
0
5
42
1.19
0.21
1.4
1.3
—
0.39
—
0
7
0
10
0.00
0.21
0.0
2.0
—
391.00
—
0
10
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
35.71
—
0
10
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
12
98
1.23
0.21
1.2
1.2
9.67
9.36
mm/h
0.02
12
98
43
392
1.10
0.21
1.4
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
40.44
—
0
14
55
509
1.08
0.20
1.6
2.1
2.61
14.91
iu/l
0.58
23
213
55
509
1.08
0.20
1.4
1.5
51.85
62.03
ug/l
1.69
44
420
42
384
1.10
0.20
1.0
1.1
0.62
1.76
u/ml
1.66
20
202
44
404
1.09
0.19
1.5
1.5
—
—
—
0
0
38
347
1.10
0.18
5.1
3.6
26.17
25.82
mg/l
0.02
27
248
26
232
1.12
0.18
1.2
1.3
—
—
nmol/l
—
0
0
13
109
1.19
0.18
2.0
2.4
9.15
8.54
mmol/l
0.18
13
109
22
194
1.14
0.18
1.2
1.4
—
—
—
0
0
42
386
1.09
0.18
1.0
1.1
1.93
1.38
u/ml
0.22
22
173
7
58
1.21
0.18
1.1
1.1
—
—
—
0
0
770
7594
1.02
0.18
1.9
1.9
1.45
1.39
mmol/l
0.48
659
6534
31
281
1.10
0.17
3.2
3.3
0.83
0.83
nmol/l
0.01
24
233
8
68
1.18
0.16
1.0
1.7
293.63
97.36
nmol/24h
—
8
68
8
70
1.14
0.16
6.1
2.5
—
—
—
0
0
18
159
1.13
0.15
1.2
1.3
164.89
214.53
pmol/l
0.36
18
159
1678
16703
1.02
0.15
5.1
4.9
5.91
5.89
mmol/l
0.24
1570
15492
1722
17283
0.98
0.14
5.0
4.9
1.44
1.45
mmol/l
0.37
1624
16224
522
5296
0.98
0.14
1.4
1.5
—
—
—
0
0
14
122
1.15
0.13
1.1
1.0
—
—
—
0
0
325
3186
1.02
0.13
3.0
3.0
0.67
0.72
ug/l
0.68
208
1899
14
159
0.88
0.13
1.4
1.5
8.85
8.73
mmol/l
0.03
14
154
18
199
0.90
0.11
2.1
2.3
—
—
—
0
0
33
308
1.07
0.11
1.0
1.1
4.63
5.98
u/ml
0.23
13
141
42
397
1.06
0.10
1.0
1.1
12.61
4.80
u/ml
0.96
24
223
1640
16448
0.98
0.09
4.3
4.2
1.38
1.31
mmol/l
1.92
1546
15327
6
55
1.09
0.09
1.8
1.3
18.93
16.17
umol/l
—
6
47
41
390
1.05
0.08
2.8
2.5
59.12
128.46
ug/min
1.60
22
243
5
65
0.77
0.08
1.2
1.1
—
—
—
0
0
20
185
1.08
0.08
1.2
1.2
—
—
—
0
0
7
64
1.09
0.08
1.0
1.3
26.71
28.78
s
—
7
64
1910
19125
0.98
0.08
32.3
23.0
134.87
136.42
g/l
4.83
1903
18963
1752
17555
0.98
0.08
5.6
5.6
2.75
2.76
mmol/l
0.05
1648
16507
7
68
1.03
0.07
1.0
1.6
0.63
0.49
e9/l
—
7
68
1910
19124
0.98
0.07
32.1
22.9
6.97
6.73
e9/l
3.23
1890
18754
127
1243
1.02
0.07
1.2
1.3
—
—
—
0
0
31
294
1.05
0.07
1.0
1.0
0.06
0.29
u/ml
—
10
101
142
1446
0.98
0.06
5.9
3.9
—
—
—
0
0
1910
19118
0.98
0.05
32.0
22.8
4.49
4.53
e12/l
2.74
1887
18753
1910
19118
0.98
0.05
32.8
23.3
40.30
40.93
%
1.63
1902
18947
1910
19118
0.98
0.05
31.9
22.8
30.24
30.30
pg
0.67
1900
18956
1733
17355
0.99
0.05
5.1
5.0
4.68
4.67
mmol/l
0.24
1641
16389
28
267
1.05
0.05
1.3
1.3
0.52
7.25
nmol/l
0.51
28
256
1910
19115
0.98
0.04
32.0
22.8
90.74
90.84
fl
0.44
1900
18954
29
302
0.96
0.04
1.3
1.2
—
—
—
0
0
33
318
1.04
0.04
1.2
1.2
—
—
—
0
0
17
180
0.94
0.04
3.4
4.7
14.94
71.23
u/ml
—
7
57
21
220
0.95
0.03
2.3
2.4
33.86
32.18
pg
1.50
21
220
14
131
1.07
0.03
1.3
1.3
81.64
76.93
umol/l
0.25
14
131
1488
14857
1.00
0.02
25.0
18.5
13.67
13.54
%
3.51
1481
14664
1910
19108
0.99
0.02
32.2
22.9
254.62
252.81
e9/l
0.58
1891
18791
107
1058
1.01
0.02
1.6
1.7
—
—
—
0
0
101
1021
0.99
0.02
1.1
1.1
—
—
—
0
0
10
94
1.06
0.01
2.0
1.6
—
—
—
0
0
23
232
0.99
0.00
1.3
1.3
0.16
0.26
nmol/l
0.64
14
181
10
98
1.02
0.00
2.5
2.6
16.48
16.36
%
—
10
98
34
335
1.01
0.00
1.0
1.1
4.47
3.06
u/ml
0.26
16
171
10
104
0.96
0.00
5.6
6.8
33.64
185.19
ug/l
—
5
65
13
126
1.03
0.00
1.8
2.1
3.20
1.89
u/field
—
5
76
24
236
1.02
0.00
3.7
2.3
1.04
0.87
%
0.19
16
163
17
165
1.03
0.00
1.3
1.2
—
—
—
0
0
20
195
1.03
0.00
1.3
1.4
1.26
1.49
nmol/l
0.59
20
175
7
71
0.99
0.00
1.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
2.5
2.5
0.57
0.62
mmol/l
—
6
60
0
7
0.00
-0.00
0.0
1.1
—
28.41
—
0
7
0
6
0.00
-0.00
0.0
1.5
—
2.60
—
0
6
8
80
1.00
-0.00
1.8
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
8
85
0.94
-0.00
1.0
1.1
132.25
193.87
iu/ml
—
8
85
8
85
0.94
-0.00
1.1
1.5
32.12
32.23
nmol/l
—
8
68
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
49
1.02
-0.00
1.2
1.2
37.46
29.84
%
—
5
44
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
2.92
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
2800.00
—
0
5
0
5
0.00
-0.00
0.0
2.2
—
1184.40
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint MENINGITIS and mortality.

Females

Parameter HR [95% CI] p-value
MENINGITIS 2.303 [1.99, 2.66] < 0.001
Birth year 0.995 [0.99, 1.0] 0.211

During the follow-up period (1.1.1998 — 31.12.2019), 686 out of 3805 females with MENINGITIS died.

Males

Parameter HR [95% CI] p-value
MENINGITIS 2.327 [2.0, 2.71] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 823 out of 3963 males with MENINGITIS died.

Mortality risk

Mortality risk for people of age

years, who have MENINGITIS.

N-year risk Females Males
1 0.233% 0.438%
5 1.237% 2.553%
10 3.441% 6.493%
15 6.682% 11.706%
20 10.829% 19.098%

Relationships between endpoints

Index endpoint: MENINGITIS – Meningitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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