viral meningitis: Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
189 |
4. Check minimum number of eventsNone |
189 |
5. Include endpointsNone |
189 |
6. Filter based on genotype QC (FinnGen only) |
172 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEUINFL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Meningitis, viral
based on the number of shared cases.
Similar with more cases:
- Meningitis
- Inflammatory diseases of the central nervous system
- Certain infectious and parasitic diseases
- Neurological diseases
- Neurological diseases, wide definition
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1037 | 609 | 424 |
| Only index persons | 980 | 583 | 397 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 36.25 | 39.74 | 31.18 |
| Only index persons | 36.97 | 39.99 | 32.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 172 | 124 | 48 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.02 |
| Median age at first event (years) | 46.24 | 43.54 | 53.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 177
- Matched controls
- 1770
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
106.2
91
*
A87.9
ICD-10 Finland
Viral meningitis, unspecified
204.7
74.7
73
6
TAB00
NOMESCO Finland
Lumbar puncture
14.3
47.5
49
46
J05AB11
ATC
valaciclovir; oral
8.6
46.2
90
190
G02.0*B02.1
ICD-10 Finland
Zoster meningitis
+∞
33.4
31
*
G02.0*B01.0
ICD-10 Finland
Varicella meningitis
+∞
32.3
30
*
R51.80
ICD-10 Finland
Headache
6.0
30.9
84
232
G02.0*A87.0
ICD-10 Finland
Enteroviral meningitis
+∞
22.4
21
*
G03.9
ICD-10 Finland
Meningitis, unspecified
+∞
21.3
20
*
G02.0
ICD-10 Finland
Meningitis in viral diseases classified elsewhere
+∞
21.3
20
*
AA1AD
NOMESCO Finland
CT of head and brain
4.0
17.9
77
286
J05AB01
ATC
aciclovir; systemic
3.9
17.2
78
299
A86
ICD-10 Finland
Unspecified viral encephalitis
+∞
16.9
16
*
B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
15.9
15
*
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
14.8
14
*
A87.8
ICD-10 Finland
Other viral meningitis
+∞
12.6
12
*
N71
ICPC
Meningitis/encephalitis
+∞
11.6
11
*
G05.1*B00.4
ICD-10 Finland
Herpesviral meningoencephalitis
+∞
11.6
11
*
5AB01, ,
NOMESCO Finland
+∞
10.5
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
10.2
55
225
H02AB06
ATC
prednisolone; systemic
2.5
8.5
100
599
N01
ICPC
Headache
3.0
8.2
43
171
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.6
8.1
30
96
R51
ICD-10 Finland
Headache
4.3
8.0
22
57
B02.9
ICD-10 Finland
Zoster without complication
4.2
7.5
21
55
R4110
NOMESCO Finland
Physiotherapy
2.5
7.4
60
298
B02.1
ICD-10 Finland
Zoster meningitis
+∞
7.3
7
*
G03.2
ICD-10 Finland
Benign recurrent meningitis [Mollaret]
+∞
7.3
7
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
7.2
89
533
XF400
NOMESCO Finland
ECG with 12 standard connections
3.1
7.2
34
127
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.1
7.1
15
20
B00.19
ICD-10 Finland
Other vesicular dermatitis caused by the herper simplex virus
23.6
6.7
9
*
ZX120
NOMESCO Finland
Intravenous
3.3
6.7
27
91
A87.0
ICD-10 Finland
Enteroviral meningitis
72.3
6.5
7
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.6
6.4
45
207
N03AX16
ATC
[U] pregabalin
2.4
6.3
51
251
B00.4
ICD-10 Finland
Herpesviral encephalitis
+∞
6.3
6
*
XA800
NOMESCO Finland
Neuropsychological investigation
4.1
6.3
18
48
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
66
42
24.46
81.24
1.5
1.4
20.02
238.28
e6/l
0.81
46
32
65
41
24.47
80.29
1.4
1.3
155.20
3.00
e6/l
4.80
45
28
52
9
80.95
47.50
1.4
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
47
5
126.78
45.36
1.4
1.2
—
—
—
0
0
29
5
68.81
25.89
1.2
1.0
—
—
—
0
0
33
16
25.02
23.63
1.4
1.1
—
—
—
0
0
30
16
22.30
20.82
1.4
1.1
—
—
—
0
0
25
8
36.05
19.87
1.4
1.1
2.57
1.66
mmol/l
—
25
8
27
15
20.97
18.46
1.3
1.0
—
—
—
0
0
24
10
27.51
17.87
1.3
1.2
—
—
—
0
0
24
21
13.03
13.79
1.3
1.1
—
—
—
0
0
17
7
26.65
12.73
1.3
1.0
91.91
—
%
—
11
0
24
53
5.08
10.60
1.3
1.1
—
5.47
—
0
11
16
10
17.43
10.57
1.6
1.7
—
—
—
0
0
18
16
12.37
10.32
1.3
1.4
273.08
161.64
e6/l
1.41
12
11
18
16
12.37
10.32
1.3
1.1
556.83
666.60
e6/l
—
12
10
16
11
15.84
10.21
1.1
1.3
—
—
—
0
0
16
14
12.43
9.27
1.7
2.3
—
—
—
0
0
43
165
3.12
8.76
1.6
1.7
—
—
—
0
0
17
19
9.77
8.76
1.1
1.4
—
—
—
0
0
52
223
2.89
8.70
2.6
2.8
5.34
3.08
e6/l
0.41
18
104
14
11
13.69
8.53
3.8
2.7
342.57
637.91
u/ml
0.63
14
11
45
186
2.90
8.00
2.1
1.9
28.79
29.44
s
0.44
45
181
130
905
2.64
7.65
10.2
9.9
4.05
4.02
e9/l
0.05
118
798
42
171
2.91
7.65
1.7
1.7
—
—
—
0
0
11
7
16.63
7.33
1.3
1.0
—
—
—
0
0
50
234
2.58
6.91
1.8
1.8
—
—
—
0
0
51
242
2.56
6.85
2.4
2.7
0.85
0.74
e6/l
0.13
17
123
13
15
9.25
6.68
1.3
1.3
0.92
0.70
e9/l
0.68
13
15
20
57
3.83
6.37
1.4
1.4
—
—
—
0
0
53
268
2.40
6.14
4.1
3.0
24.03
62.85
ng/l
0.88
32
170
11
11
10.57
6.12
1.9
2.6
—
—
—
0
0
22
73
3.30
5.60
1.4
1.6
—
—
—
0
0
82
517
2.09
5.42
4.4
3.1
—
—
—
0
0
27
104
2.88
5.36
1.9
1.6
—
—
—
0
0
5
0
+∞
5.23
1.4
0.0
—
—
—
0
0
69
415
2.09
5.10
4.1
2.8
0.13
0.44
e6/l
1.98
45
304
15
45
3.55
4.43
1.4
1.4
—
—
—
0
0
79
521
1.93
4.36
3.9
3.5
21.43
19.40
ng/l
0.17
43
312
13
30
4.59
4.22
1.2
1.3
—
—
—
0
0
13
30
4.59
4.22
1.2
1.3
—
—
—
0
0
129
1014
2.00
4.08
6.2
4.7
—
273.84
—
0
19
18
65
2.97
3.99
1.9
1.6
—
—
—
0
0
10
19
5.51
3.89
1.0
1.2
—
—
—
0
0
58
358
1.92
3.81
1.5
1.7
0.58
1.02
mg/l
1.20
46
273
25
113
2.41
3.62
1.6
1.2
86.39
124.67
u/ml
0.33
25
102
7
9
8.04
3.59
1.6
1.0
2312.43
1522.67
miu/ml
—
7
9
107
810
1.81
3.59
3.8
3.3
89.91
86.18
ug/l
0.12
102
771
16
59
2.88
3.42
3.6
11.1
1.52
1.48
%
0.07
16
54
6
8
7.71
3.08
1.3
1.3
12.83
17.00
u/l
—
6
8
93
696
1.71
3.07
2.6
2.6
77.08
76.09
nmol/l
0.11
84
642
11
32
3.60
2.95
1.9
2.7
1.00
2.18
index
—
5
17
12
38
3.31
2.91
3.0
2.3
116.57
126.45
g/l
—
7
29
93
708
1.66
2.79
8.5
7.6
1.21
1.21
mmol/l
0.16
85
608
11
37
3.10
2.54
1.6
1.9
44.36
40.51
nmol/l
0.12
11
37
54
365
1.69
2.51
3.9
3.8
1.02
1.02
kg/l
0.62
37
238
72
529
1.61
2.40
4.1
3.2
28.26
28.52
u/l
0.05
66
500
43
278
1.72
2.33
3.4
2.2
—
—
—
0
0
6
13
4.74
2.29
1.0
1.2
—
—
—
0
0
6
13
4.74
2.29
1.0
1.2
—
—
—
0
0
10
35
2.97
2.25
2.0
1.5
—
—
—
0
0
5
9
5.68
2.23
1.6
1.0
—
—
—
0
0
142
1242
1.72
2.19
4.7
4.7
14.46
14.61
pmol/l
0.32
135
1165
45
302
1.66
2.12
3.8
2.4
—
—
—
0
0
130
1120
1.61
2.04
3.5
3.2
51.00
42.42
u/l
0.45
125
1077
10
38
2.73
2.04
1.1
1.3
—
—
—
0
0
105
864
1.53
2.01
5.6
3.8
0.00
8.29
estimate
0.50
18
196
131
1134
1.60
1.98
4.0
3.7
—
—
—
0
0
24
137
1.87
1.95
3.6
11.5
4.89
5.12
kpa
0.66
24
130
24
137
1.87
1.95
3.6
11.5
12.43
12.30
kpa
0.06
24
130
14
65
2.25
1.94
3.9
17.3
16.59
15.76
%
0.57
14
60
65
487
1.53
1.91
5.0
3.1
0.00
0.01
estimate
0.50
16
158
103
854
1.49
1.84
5.5
3.7
0.00
0.00
estimate
-0.00
19
191
164
1518
2.09
1.83
24.5
14.3
16.24
20.69
mg/l
1.84
144
1236
27
165
1.75
1.78
4.3
2.0
—
—
—
0
0
5
13
3.92
1.72
1.6
1.2
—
—
—
0
0
104
872
1.47
1.70
5.6
3.8
0.00
0.00
estimate
-0.00
18
184
146
1314
1.63
1.70
28.3
17.6
13.42
13.52
%
0.51
146
1300
28
178
1.68
1.61
2.6
2.7
6.57
5.95
umol/l
0.15
23
150
88
721
1.44
1.59
3.1
2.9
—
—
estimate
—
0
0
10
44
2.35
1.58
1.4
1.3
—
—
—
0
0
10
44
2.35
1.58
1.3
1.4
—
—
—
0
0
64
499
1.44
1.49
3.4
3.2
2.33
2.35
mmol/l
0.57
59
461
9
38
2.44
1.48
1.1
1.4
—
—
—
0
0
5
16
3.18
1.45
1.4
1.3
—
—
—
0
0
14
75
1.94
1.39
1.1
1.3
—
—
—
0
0
15
83
1.88
1.36
5.5
7.0
24.96
25.04
mmol/l
0.03
15
83
53
408
1.43
1.31
1.8
1.7
—
—
—
0
0
5
18
2.83
1.29
1.0
1.3
—
—
—
0
0
154
1431
1.59
1.25
6.1
5.6
1.76
1.83
mu/l
0.36
147
1348
10
49
2.10
1.24
2.9
2.0
—
—
—
0
0
24
159
1.59
1.20
1.8
2.9
0.81
0.74
ug/l
0.16
13
99
6
26
2.35
1.19
1.2
1.7
—
—
—
0
0
77
642
1.35
1.16
5.8
3.6
0.00
0.02
estimate
0.68
17
164
5
20
2.54
1.16
1.2
1.6
—
—
—
0
0
5
20
2.54
1.16
1.0
1.6
—
—
—
0
0
5
20
2.54
1.16
1.0
1.6
—
—
—
0
0
8
40
2.05
1.13
1.3
2.3
201.00
193.63
%
—
8
40
154
1439
1.54
1.12
4.7
4.4
5.67
5.77
mmol/l
0.62
145
1349
5
21
2.42
1.10
1.0
1.6
—
—
—
0
0
5
21
2.42
1.10
1.2
1.6
—
—
—
0
0
5
21
2.42
1.10
1.2
1.6
—
—
—
0
0
15
90
1.73
1.08
1.1
1.0
—
—
—
0
0
159
1499
1.60
1.07
25.6
15.4
3.92
3.94
mmol/l
0.64
159
1466
9
45
2.05
1.06
1.2
1.6
—
—
—
0
0
54
431
1.36
1.06
1.4
1.3
0.63
1.24
u/ml
1.09
16
139
9
50
1.84
0.98
1.2
1.1
—
—
—
0
0
9
50
1.84
0.98
1.2
1.1
—
—
—
0
0
7
36
1.98
0.98
1.3
1.3
—
—
—
0
0
150
1404
1.45
0.97
3.9
3.8
1.21
1.24
mmol/l
0.19
139
1309
46
368
1.34
0.89
2.7
3.1
1480.59
1118.88
ng/l
0.30
40
306
166
1592
1.69
0.89
16.7
11.1
25.94
25.19
u/l
0.32
166
1561
28
206
1.43
0.88
5.3
2.1
—
—
—
0
0
75
645
1.28
0.85
2.4
2.0
97.59
97.72
pmol/l
0.01
39
324
27
199
1.42
0.85
1.7
1.9
1.44
1.36
%
0.19
22
175
28
208
1.41
0.84
2.9
4.1
28.71
22.56
%
0.92
12
94
6
32
1.90
0.82
1.0
1.1
—
1.85
—
0
9
44
355
1.32
0.80
2.4
2.3
—
—
—
0
0
0
24
0.00
0.80
0.0
1.2
—
91.20
—
0
5
48
393
1.30
0.79
5.3
4.1
16.17
10.47
mg/mmol
0.27
25
240
152
1440
1.39
0.78
20.7
13.1
87.67
87.43
ml/min/173m2
0.05
145
1330
165
1588
1.58
0.75
27.8
17.1
74.73
72.31
umol/l
0.45
165
1572
5
24
2.11
0.75
1.4
1.7
—
—
—
0
0
19
134
1.47
0.75
4.1
3.5
—
—
—
0
0
27
205
1.37
0.73
4.6
2.5
26.64
23.51
%
0.58
27
192
5
26
1.95
0.71
1.2
1.5
—
—
—
0
0
29
225
1.35
0.69
4.3
2.4
2.28
2.39
g/l
0.51
29
206
45
373
1.28
0.67
1.5
1.5
—
—
—
0
0
5
28
1.81
0.66
12.4
2.9
14.74
7.69
pmol/l
—
5
28
7
44
1.61
0.66
1.1
1.1
—
0.91
—
0
7
5
29
1.74
0.64
1.4
1.7
—
—
—
0
0
11
71
1.59
0.63
6.5
2.9
23.54
24.61
mmol/l
0.74
11
71
23
175
1.36
0.62
13.7
7.0
1.08
1.06
mmol/l
0.14
23
156
18
131
1.42
0.62
5.4
4.1
18.73
59.93
ug/l
0.34
12
105
6
36
1.69
0.57
2.0
2.5
—
—
—
0
0
6
37
1.64
0.56
1.2
1.4
—
—
—
0
0
17
125
1.40
0.56
1.5
1.3
—
—
—
0
0
6
38
1.60
0.55
1.0
2.2
—
—
—
0
0
50
433
1.22
0.51
1.7
1.6
22.80
22.09
nmol/l
0.17
39
367
155
1495
1.30
0.49
4.7
4.6
4.65
4.71
mmol/l
0.33
148
1415
15
111
1.38
0.48
4.5
2.4
18.63
59.85
u/ml
1.12
15
105
11
77
1.46
0.47
1.2
1.6
—
—
—
0
0
22
176
1.29
0.44
4.5
6.8
106.32
104.53
mmol/l
1.49
22
176
11
78
1.44
0.44
5.0
12.1
24.65
24.39
mmol/l
0.13
11
73
13
171
0.74
0.42
3.4
4.3
30.00
31.89
%
—
7
113
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
12
88
1.39
0.41
1.3
1.5
89.43
322.21
miu/ml
—
7
44
11
148
0.73
0.40
9.6
6.2
—
—
—
0
0
20
161
1.27
0.39
1.2
1.3
21.83
121.40
u/ml
—
6
64
154
1493
1.24
0.39
4.6
4.5
1.48
1.49
mmol/l
0.11
146
1407
14
107
1.33
0.38
4.6
2.9
63.44
69.09
ml/min/173m2
—
9
45
38
330
1.19
0.38
1.3
1.4
4.11
10.88
u/ml
0.95
13
128
31
264
1.21
0.38
3.3
2.4
2.41
2.43
mmol/l
0.60
26
236
155
1508
1.22
0.34
5.3
5.0
2.66
2.79
mmol/l
1.06
148
1422
10
76
1.33
0.29
1.7
1.6
—
—
—
0
0
8
62
1.30
0.28
1.8
1.3
—
—
—
0
0
5
72
0.69
0.26
1.6
1.4
—
—
—
0
0
9
77
1.18
0.24
2.9
11.4
0.60
0.71
%
—
9
77
0
11
0.00
0.21
0.0
1.3
—
106.31
—
0
11
41
376
1.12
0.21
1.9
2.8
339.28
326.00
umol/l
0.39
36
336
44
473
0.91
0.18
6.7
3.9
0.00
0.01
estimate
0.50
17
181
5
68
0.73
0.17
1.0
1.1
1.51
1.60
g/l
—
5
68
5
69
0.72
0.17
1.0
1.1
0.87
0.84
g/l
—
5
69
18
158
1.16
0.17
1.8
1.8
3.33
3.46
mmol/l
0.21
12
115
9
80
1.13
0.15
2.9
10.7
1.11
1.40
%
—
9
80
13
113
1.16
0.13
2.7
2.6
5403.49
4008.96
u/l
—
7
45
168
1663
1.20
0.13
34.1
21.8
133.89
135.00
g/l
0.52
168
1650
168
1661
1.22
0.13
34.0
22.0
40.11
40.48
%
0.66
168
1646
168
1660
1.24
0.13
33.9
21.6
90.73
90.68
fl
0.05
168
1647
23
210
1.11
0.13
2.2
1.9
3.11
3.32
ratio
0.39
17
164
38
358
1.08
0.11
1.4
1.3
10.47
26.23
iu/ml
2.69
15
118
6
73
0.82
0.08
4.7
2.6
1.23
1.37
%
—
6
73
67
654
1.04
0.06
1.8
1.9
1.31
1.37
mmol/l
0.34
57
563
10
101
0.99
0.00
1.2
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.8
—
1.00
—
0
9
0
8
0.00
-0.00
0.0
1.4
—
194.88
—
0
8
6
61
0.98
-0.00
1.0
1.4
—
7.27
—
0
17
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
129.00
—
0
5
8
87
0.92
-0.00
1.5
1.9
5.72
3.05
ug/l
—
8
76
6
68
0.88
-0.00
2.2
1.9
—
—
—
0
0
5
55
0.91
-0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
56.80
—
0
5
5
53
0.94
-0.00
2.6
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
7
76
0.92
-0.00
1.3
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
54
0.92
-0.00
2.0
1.5
61.10
50.81
ug/l
—
5
54
Mortality – FinRegistry
↥Association
Association between endpoint G6_MENINGVIR and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have G6_MENINGVIR.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: G6_MENINGVIR – Meningitis, viral
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data