Other meningitis

G6_MENINGOTH

infectious meningitis: Inflammation of the meninges of the brain and/or spinal cord caused by an infectious agent (viral, bacterial, or fungal). Symptoms include headache, fever, vomiting, neck stiffness, photophobia, confusion, and seizures.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

691

4. Check minimum number of events

None

691

5. Include endpoints

None

691

6. Filter based on genotype QC (FinnGen only)

611

Control definitions (FinnGen only)

Control exclude
G6_NEUINFL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4841 2409 2393
Only index persons 4163 2151 2012
Unadjusted period prevalence (%)
Whole population 0.07 0.07 0.07
Only index persons 0.08 0.08 0.08
Median age at first event (years)
Whole population 40.27 41.58 38.59
Only index persons 37.69 39.51 35.74

-FinnGen-

Key figures

All Female Male
Number of individuals 611 383 228
Unadjusted period prevalence (%) 0.12 0.14 0.10
Median age at first event (years) 44.82 43.35 47.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
636
Matched controls
6355
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G03.9
ICD-10 Finland
Meningitis, unspecified
13284.0
307.7
462
*
A87.9
ICD-10 Finland
Viral meningitis, unspecified
94.3
196.2
103
13
TAB00
NOMESCO Finland
Lumbar puncture
14.0
153.1
158
147
3229X
ICD-9 Finland
Meningitis of unspecified cause, Meningitis, unspecified
+∞
90.8
85
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.3
78.1
155
308
AA1AD
NOMESCO Finland
CT of head and brain
4.3
72.4
302
1099
R51.80
ICD-10 Finland
Headache
4.2
61.2
225
733
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
9.1
51.4
66
80
G03.0
ICD-10 Finland
Nonpyogenic meningitis
+∞
44.3
42
*
G03.8
ICD-10 Finland
Meningitis due to other specified causes
+∞
43.2
41
*
R50.9
ICD-10 Finland
Fever, unspecified
3.5
38.7
167
586
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
400.1
38.5
38
*
N03AX14
ATC
levetiracetam; systemic
7.5
31.7
47
67
G03.1
ICD-10 Finland
Chronic meningitis
+∞
29.4
28
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.5
27.7
110
361
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
27.2
343
2049
A86
ICD-10 Finland
Unspecified viral encephalitis
62.8
26.2
30
5
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
25.2
24
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
23.6
136
552
R51
ICD-10 Finland
Headache
3.9
21.3
67
187
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
20.9
20
*
G03.2
ICD-10 Finland
Benign recurrent meningitis [Mollaret]
+∞
19.9
19
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.2
19.5
54
137
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
19.5
173
860
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
18.9
128
560
XA800
NOMESCO Finland
Neuropsychological investigation
4.2
18.9
53
136
WX882
NOMESCO Finland
High dependency care
5.8
18.8
35
63
G00.1
ICD-10 Finland
Pneumococcal meningitis
+∞
17.8
17
*
H02AB06
ATC
prednisolone; systemic
2.0
17.0
324
2149
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.0
16.6
78
280
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
6.0
16.3
29
50
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
48.8
16.1
19
*
AAF00
NOMESCO Finland
Ventriculostomy
22.7
15.6
22
10
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.6
15.5
30
56
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
39.1
15.5
19
5
PA2AD
NOMESCO Finland
CT angiography of brain
16.6
15.3
24
15
0499X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Unspecified non-arthropod-borne viral diseases of central nervous system
58.1
14.8
17
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.2
14.7
40
100
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
11.7
14.4
26
23
WX872
NOMESCO Finland
Intensive care
3.8
14.2
44
121
L04AX01
ATC
azathioprine; systemic
3.8
14.2
45
126
N71
ICPC
Meningitis/encephalitis
+∞
13.6
13
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
13.5
113
539
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.5
13.5
49
150
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
6.2
13.5
23
38
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
6.5
13.3
22
35
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
5.6
13.1
25
46
G44.8
ICD-10 Finland
Other specified headache syndromes
6.3
13.0
22
36
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
13.3
13.0
22
17
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.1
12.8
35
88
N03AX12
ATC
[U] gabapentin; oral
2.2
12.6
121
611
G51.0
ICD-10 Finland
Bell palsy
4.8
12.5
28
60
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
12.4
121
615
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
6.2
12.2
21
35
N02AX02
ATC
tramadol; systemic, rectal
1.8
12.1
277
1886
N03AX16
ATC
[U] pregabalin
2.0
11.9
154
871
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
3.8
11.8
36
98
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
11.7
77
329
A41.9
ICD-10 Finland
Sepsis, unspecified
4.2
11.5
31
77
G05.1*B00.4
ICD-10 Finland
Herpesviral meningoencephalitis
+∞
11.5
11
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.0
11.4
52
183
G91.0
ICD-10 Finland
Communicating hydrocephalus
15.4
11.4
18
12
H47.1
ICD-10 Finland
Papilloedema, unspecified
11.4
11.1
20
18
B34.9
ICD-10 Finland
Viral infection, unspecified
3.8
11.1
34
93
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
11.1
97
471
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
11.0
155
900
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
11.0
133
732
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.5
11.0
71
301
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
44.1
10.9
13
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
10.9
175
1060
H02AB07
ATC
prednisone; oral
2.3
10.9
94
453
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
5.3
10.8
22
43
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
10.8
10.8
20
19
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
10.8
105
532
ZXC95
NOMESCO Finland
Use of surgical navigator
8.2
10.7
23
29
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.8
10.6
33
91
R42
ICD-10 Finland
Dizziness and giddiness
1.9
10.5
153
897
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
5.5
10.4
20
37
A87.8
ICD-10 Finland
Other viral meningitis
111.7
10.4
11
*
G01*A69.2
ICD-10 Finland
Meningitis (in) Lyme disease
+∞
10.4
10
*
AAA10
NOMESCO Finland
Biopsy through craniotomy
+∞
10.4
10
*
N03AF02
ATC
oxcarbazepine; oral
3.8
10.4
32
88
J05AB11
ATC
valaciclovir; oral
2.1
10.1
112
595
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
10.3
10.1
19
19
G44.2
ICD-10 Finland
Tension-type headache
2.1
10.1
111
589
G91.1
ICD-10 Finland
Obstructive hydrocephalus
17.0
9.9
15
9
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.4
9.9
74
335
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
55.8
9.7
11
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
5.1
9.6
20
40
N06AA09
ATC
amitriptyline; systemic
2.5
9.6
64
275
J45.8
ICD-10 Finland
Mixed asthma
3.8
9.5
29
79
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.9
9.5
44
157
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
22.1
9.4
13
6
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
9.3
252
1766
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.5
9.3
32
95
ZX120
NOMESCO Finland
Intravenous
2.4
9.2
67
300
H02AB09
ATC
hydrocortisone; systemic
4.1
9.1
25
63
A02BC02
ATC
pantoprazole; systemic
1.7
9.0
416
3344
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
50.7
8.7
10
*
WX704
NOMESCO Finland
Intubation
2.4
8.6
61
269
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
7.1
8.6
20
29
ZXD05
NOMESCO Finland
Urgent procedure
1.7
8.6
197
1316
SPAT1255
SPAT
Intravenous administration of medicine
2.7
8.5
46
178
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.8
8.5
43
161
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.1
8.5
80
399
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
8.5
282
2074
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
4.4
8.4
21
49
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
8.4
78
387
B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
8.3
8
*
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
8.7
8.3
17
20
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
8.1
88
462
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
11.9
8.1
14
12
H53.4
ICD-10 Finland
Visual field defects
4.4
8.0
20
47
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
8.0
166
1076
5AB01, ,
NOMESCO Finland
45.5
7.7
9
*
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.3
7.6
28
87
J01DB01
ATC
cefalexin; oral
1.8
7.6
522
4555
N03AX18
ATC
lacosamide; systemic
10.2
7.6
14
14
TKC20
NOMESCO Finland
Catheterisation of bladder
2.5
7.4
45
185
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
2.9
7.3
35
127
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
11.0
7.3
13
12
G00.2
ICD-10 Finland
Streptococcal meningitis
+∞
7.3
7
*
G09
ICD-10 Finland
Sequelae of inflammatory diseases of central nervous system
+∞
7.3
7
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.3
7.3
53
237
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
15.9
7.2
11
7
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
7.2
147
944
F43.1
ICD-10 Finland
Post-traumatic stress disorder
3.0
7.2
31
106
WX402
NOMESCO Finland
General anaesthesia
1.7
7.2
145
928
ABE50
NOMESCO Finland
Occipitocervical decompression
30.4
7.2
9
*
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
6.1
7.1
18
30
N01
ICPC
Headache
1.9
7.1
97
553
R25.2
ICD-10 Finland
Cramp and spasm
3.6
7.0
23
66
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.8
7.0
35
130
N05BA04
ATC
oxazepam; oral
1.7
6.9
165
1104
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
6.9
170
1148
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.0
6.9
73
381
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.9
6.8
20
53
WX730
NOMESCO Finland
Conventional respirator
6.8
6.8
16
24
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.5
6.7
42
175
T78.4
ICD-10 Finland
Allergy, unspecified
2.7
6.7
36
139
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
2.8
6.7
32
116
G43.9
ICD-10 Finland
Migraine, unspecified
2.2
6.7
55
259
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.8
6.7
33
122
AAF15
NOMESCO Finland
Ventriculoatrial shunt
22.8
6.7
9
*
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
22.8
6.7
9
*
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
22.8
6.7
9
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.8
6.7
20
54
WX725
NOMESCO Finland
Noninvasive ventilation
2.5
6.7
42
176
H53.2
ICD-10 Finland
Diplopia
3.2
6.6
26
84
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.1
6.6
61
302
J01MA02
ATC
ciprofloxacin; systemic
1.6
6.6
220
1596
AA5PD
NOMESCO Finland
CT examination of brain pefusion
8.8
6.6
13
15
P01AB01
ATC
metronidazole; oral, rectal
1.6
6.5
247
1844
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
6.5
84
470
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
6.3
63
321
WZC00
NOMESCO Finland
Treatment plan or consultation
1.6
6.3
233
1726
XCK00
NOMESCO Finland
Perimetry
2.6
6.3
37
150
B00.4
ICD-10 Finland
Herpesviral encephalitis
+∞
6.3
6
*
G02.0
ICD-10 Finland
Meningitis in viral diseases classified elsewhere
+∞
6.3
6
*
G06.0
ICD-10 Finland
Intracranial abscess and granuloma
+∞
6.3
6
*
G01*A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
6.3
6
*
A84.9
ICD-10 Finland
Tick-borne viral encephalitis, unspecified
+∞
6.3
6
*
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
26.9
6.2
8
*
J01MA14
ATC
moxifloxacin; systemic
2.1
6.2
56
274
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
6.2
127
814
UKC02
NOMESCO Finland
Cystoscopy
1.9
6.2
86
492
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
6.2
338
2721
M01AE02
ATC
naproxen; oral, rectal
1.5
6.2
359
2927
A03
ICPC
Fever
1.7
6.1
123
784
S22.4
ICD-10 Finland
Multiple fractures of ribs
4.2
6.1
16
39
S06.0
ICD-10 Finland
Concussion
1.9
6.1
79
442
N03AE01
ATC
clonazepam; systemic
2.5
6.1
38
159
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
3.1
6.0
25
84

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
183
50
50.94
305.00
2.2
1.1
—
—
—
0
0
218
134
24.21
271.88
1.9
1.1
3.31
3.79
mmol/l
3.90
209
126
225
150
22.65
269.83
2.1
1.2
1032.99
446.51
mg/l
9.39
219
142
199
119
23.86
250.37
2.1
1.2
—
—
—
0
0
193
137
19.77
222.07
2.1
1.3
1789.63
975.76
e6/l
0.35
155
109
191
134
19.93
221.05
2.0
1.2
471.73
5.75
e6/l
3.55
151
100
76
63
13.55
77.52
1.8
1.2
—
—
—
0
0
162
361
5.67
71.78
1.5
1.3
40.30
35.33
au/ml
—
10
28
163
401
5.12
63.94
2.9
2.5
33.95
20.11
au/ml
0.74
12
36
307
1373
3.39
49.85
5.0
4.1
—
—
—
0
0
39
51
8.07
28.31
1.3
1.1
82.87
33.26
mg/l
1.82
30
40
283
1616
2.35
23.98
3.1
2.1
158.38
273.86
u/l
1.15
278
1545
34
49
7.27
22.66
1.1
1.1
538.12
220.21
mg/l
1.39
26
43
29
36
8.39
21.90
1.3
1.2
—
—
—
0
0
360
2333
2.25
21.89
11.9
11.4
1.17
1.19
inr
0.34
314
1929
441
3167
2.28
20.03
6.9
5.0
6.51
6.54
mmol/l
0.14
429
2975
33
54
6.39
19.54
1.5
1.3
—
—
—
0
0
379
2609
2.12
18.52
10.0
7.1
1.21
1.21
mmol/l
1.43
338
2257
28
42
6.92
17.97
1.4
1.1
0.77
0.51
ratio
—
8
24
122
536
2.58
17.78
10.5
9.2
7.42
7.42
ph
0.05
79
308
402
2857
2.10
17.69
7.6
6.4
10.68
11.05
umol/l
0.21
389
2721
435
3194
2.14
17.43
11.6
9.7
4.39
4.00
e9/l
2.18
386
2787
347
2346
2.05
17.38
9.3
6.5
1.21
1.21
mmol/l
1.52
333
2182
120
529
2.56
17.34
10.6
9.2
1.12
0.92
mmol/l
0.22
98
442
293
1866
2.05
17.29
8.9
6.2
—
—
—
0
0
31
54
5.98
17.25
1.6
1.3
2.74
2.84
g/l
0.13
23
38
31
54
5.98
17.25
1.6
1.3
5.75
6.39
g/l
0.59
23
39
31
54
5.98
17.25
1.6
1.3
0.34
0.42
g/l
0.49
23
39
152
749
2.35
17.21
1.9
2.0
—
—
—
0
0
97
387
2.78
17.08
2.2
1.7
1.50
1.38
g/l
0.09
91
360
60
183
3.51
16.69
2.2
1.7
1.07
2.76
ug/l
0.53
54
163
301
1970
2.00
16.12
3.6
3.6
20.25
84.01
ng/l
1.11
190
1302
40
98
4.29
15.10
1.9
1.4
0.57
0.60
g/l
0.09
32
80
392
2865
1.96
14.68
9.1
6.5
0.58
0.56
e9/l
0.69
345
2471
26
45
5.98
14.55
2.1
2.0
516.52
423.29
e6/l
0.53
21
34
376
2717
1.94
14.49
9.4
6.5
27.76
28.30
%
0.40
363
2588
26
46
5.85
14.23
2.2
2.2
195.33
205.95
e6/l
0.10
21
38
391
2876
1.93
14.13
9.2
6.5
0.04
0.04
e9/l
0.50
344
2479
330
2302
1.90
13.97
5.9
5.0
35.34
36.34
g/l
2.22
316
2173
396
2934
1.92
13.89
9.2
6.5
2.10
1.95
e9/l
0.31
354
2601
365
2635
1.90
13.85
9.5
6.5
2.74
2.84
%
0.37
351
2480
400
2976
1.92
13.82
9.4
6.8
0.19
0.19
e9/l
0.05
352
2610
264
1718
1.92
13.79
2.9
2.5
48.80
64.00
u/l
3.46
252
1605
365
2641
1.89
13.69
9.6
6.6
8.77
8.73
%
0.08
350
2490
361
2633
1.86
12.89
9.7
6.6
0.62
0.69
%
1.75
347
2467
363
2668
1.84
12.48
9.1
6.4
57.08
57.03
%
0.03
355
2560
450
3554
1.91
12.11
7.5
4.5
6201.20
1572.39
e6/l
—
10
57
157
894
2.00
11.86
4.5
3.7
0.82
0.82
mmol/l
0.03
151
855
246
1624
1.84
11.85
4.4
3.0
—
—
—
0
0
61
239
2.71
11.03
4.1
2.1
5.44
9.31
iu/ml
0.66
25
55
201
1281
1.83
10.63
1.9
1.8
1.31
1.21
mg/l
0.15
156
979
19
17
11.47
10.60
2.2
1.8
28.26
28.47
%
0.01
19
17
496
4124
1.92
10.40
11.4
8.1
76.52
78.22
u/l
0.48
489
3909
103
529
2.13
10.17
3.6
3.8
7.38
7.39
ph
0.32
63
318
64
271
2.51
9.89
8.4
6.3
—
—
—
0
0
36
111
3.38
9.85
2.1
4.0
32.03
35.81
umol/l
0.57
36
101
32
92
3.61
9.73
1.3
1.4
68.15
59.72
mmol/l
0.42
26
79
39
131
3.10
9.30
8.9
9.9
1.16
1.25
mmol/l
0.36
34
113
48
184
2.74
9.05
1.4
1.3
—
—
—
0
0
248
1754
1.68
8.74
4.9
3.2
26.37
84.36
e6/l
0.89
204
1344
21
49
4.39
8.45
1.0
1.1
—
—
—
0
0
85
435
2.10
8.43
10.5
9.1
—
—
—
0
0
15
14
10.93
8.32
1.2
1.0
—
—
—
0
0
112
637
1.92
8.26
2.0
1.6
—
—
—
0
0
94
505
2.01
8.17
3.8
3.8
1.79
1.62
mmol/l
0.18
85
431
200
1357
1.69
8.13
5.3
4.0
90.86
92.00
%
0.28
193
1334
14
13
10.97
7.82
1.2
1.0
14.18
5.34
mg/g
1.00
14
13
183
1224
1.69
7.80
4.1
2.6
7.15
6.43
e6/l
0.19
174
1113
153
975
1.75
7.77
4.0
3.8
69.82
340.65
ng/l
2.29
103
703
372
2970
1.61
7.71
6.0
3.7
0.00
0.00
estimate
-0.00
77
639
331
2572
1.60
7.68
3.3
2.7
—
—
estimate
—
0
0
135
836
1.78
7.55
1.5
1.4
681.18
505.74
titre
0.39
34
188
242
1756
1.61
7.42
3.0
2.3
—
—
—
0
0
375
3025
1.58
7.24
6.0
3.8
0.00
0.02
estimate
1.32
78
605
26
80
3.34
7.17
1.1
1.4
—
—
—
0
0
26
80
3.34
7.17
1.1
1.4
—
—
—
0
0
26
80
3.34
7.17
1.1
1.4
—
—
—
0
0
26
80
3.34
7.17
1.1
1.4
—
—
—
0
0
160
1056
1.69
7.09
4.3
2.8
496.71
536.28
mosm/kgh2o
1.37
147
923
192
1330
1.63
7.04
2.8
2.2
—
—
—
0
0
447
3774
1.62
6.97
7.4
4.4
—
3.32
—
0
8
28
93
3.10
6.84
1.2
1.2
—
—
—
0
0
370
2998
1.56
6.82
6.0
3.7
16.77
5.48
estimate
0.29
81
639
209
1489
1.60
6.79
4.7
3.1
0.31
0.41
e6/l
0.32
165
1088
271
2054
1.55
6.72
6.4
3.8
55.26
98.63
e6/l
0.85
211
1431
88
496
1.90
6.62
4.7
5.1
0.79
0.86
%
0.11
33
152
308
2422
1.52
6.34
5.0
3.3
6.26
6.21
ph
0.34
188
1401
29
103
2.90
6.33
4.1
3.6
3.61
4.29
e9/l
0.64
29
103
156
1052
1.64
6.28
1.6
1.7
99310786.90
35379899.19
pmol/l
0.28
145
896
31
115
2.78
6.26
1.7
1.4
145.00
152.96
au/ml
—
7
39
83
470
1.88
6.15
4.6
4.9
0.45
0.51
%
0.15
31
134
14
21
6.78
6.06
1.8
1.1
—
—
—
0
0
62
321
2.03
5.96
2.5
3.0
127.68
130.65
g/l
0.55
62
313
215
1591
1.53
5.73
5.3
4.1
7.40
7.40
ph
0.25
162
1120
81
467
1.84
5.67
4.9
5.2
0.21
0.16
%
0.12
28
123
312
2503
1.48
5.58
3.3
2.6
75.67
75.67
nmol/l
0.00
296
2283
112
713
1.69
5.58
3.1
3.1
3.82
5.73
e9/l
1.44
93
641
34
141
2.49
5.54
4.4
3.3
52.74
58.17
%
1.25
34
141
17
37
4.69
5.51
1.2
1.1
1488.41
1666.81
miu/ml
0.22
17
37
21
67
3.20
5.50
1.2
1.3
—
—
—
0
0
186
1344
1.54
5.50
2.1
2.1
—
—
—
0
0
86
512
1.78
5.42
2.1
2.1
0.00
0.02
estimate
0.50
18
123
22
73
3.08
5.41
2.5
2.6
—
29.73
—
0
10
5
0
+∞
5.21
1.2
0.0
—
—
—
0
0
289
2305
1.46
5.21
5.8
3.5
0.03
0.02
estimate
0.15
64
533
448
3894
1.51
5.17
4.4
3.4
52.74
42.03
u/l
1.33
439
3702
81
481
1.78
5.15
5.4
5.5
0.11
0.04
%
0.59
27
113
124
827
1.62
5.14
4.0
3.0
2.66
2.60
e6/l
0.03
58
394
51
261
2.04
5.08
6.5
3.9
—
—
—
0
0
284
2267
1.45
5.05
2.2
2.0
102.43
96.45
pmol/l
1.04
157
1201
30
126
2.45
4.79
1.9
1.5
—
—
—
0
0
119
799
1.60
4.78
1.6
1.9
—
—
—
0
0
45
226
2.06
4.72
1.4
1.4
—
—
—
0
0
64
367
1.83
4.57
6.8
3.7
7.41
7.42
ph
0.16
52
300
87
550
1.67
4.43
2.3
3.0
1.66
1.81
%
0.88
80
488
245
1938
1.43
4.42
3.8
3.3
34.08
31.80
u/l
0.47
237
1842
213
1644
1.44
4.39
4.0
2.8
0.00
0.07
—
5
29
12
24
5.07
4.33
1.3
1.3
112.83
145.43
nmol/l
1.33
12
24
11
20
5.57
4.30
1.5
1.8
0.27
0.25
e9/l
—
6
9
22
84
2.67
4.26
1.2
1.3
—
—
—
0
0
73
445
1.72
4.25
2.4
2.2
6.07
6.10
ph
0.12
49
276
62
361
1.79
4.23
2.3
2.3
4.75
6.42
ug/l
0.68
53
324
68
409
1.74
4.15
2.1
2.9
66.70
71.61
e9/l
0.73
50
290
176
1322
1.46
4.15
4.9
3.6
—
0.14
—
0
14
73
449
1.71
4.12
1.6
1.4
—
—
—
0
0
44
234
1.94
3.97
2.4
2.2
20.16
20.97
s
0.77
37
212
50
278
1.87
3.96
2.3
2.5
0.66
0.61
%
0.69
50
278
186
2355
0.70
3.95
2.9
3.0
—
—
—
0
0
15
48
3.17
3.94
1.2
1.2
—
—
—
0
0
72
447
1.69
3.93
4.8
3.9
7.38
7.36
ph
1.31
63
324
217
1710
1.41
3.90
5.5
3.1
0.00
0.00
estimate
0.80
68
513
22
89
2.52
3.83
2.0
1.6
—
—
—
0
0
193
1496
1.42
3.79
1.8
1.6
20.98
20.81
nmol/l
0.06
170
1272
6
5
12.09
3.77
1.0
1.0
—
—
—
0
0
115
813
1.50
3.64
1.8
1.7
1302.74
1169.97
nmol/l
0.77
96
614
176
1351
1.42
3.64
2.8
2.7
334.52
334.80
umol/l
0.01
166
1197
24
104
2.36
3.63
1.4
1.2
10.27
3.76
u/ml
0.69
11
45
211
1672
1.39
3.62
6.6
6.2
—
—
—
0
0
55
327
1.75
3.52
1.4
1.2
—
—
—
0
0
176
1358
1.41
3.52
6.6
5.0
—
—
—
0
0
56
335
1.74
3.51
2.4
3.4
166.37
187.28
ng/l
0.16
49
300
34
173
2.02
3.50
1.7
1.3
8.62
10.80
u/ml
—
9
32
207
1648
1.38
3.42
6.6
3.8
0.00
0.01
estimate
0.96
72
601
29
140
2.12
3.42
3.3
3.1
2.14
2.03
index
0.04
15
76
55
330
1.73
3.42
2.5
2.5
—
—
—
0
0
577
5437
1.65
3.37
26.3
14.3
24.37
22.04
mg/l
1.00
538
4397
27
128
2.16
3.34
1.6
1.4
214.67
241.70
u/ml
0.30
15
77
14
48
2.96
3.31
3.6
3.1
—
—
—
0
0
34
177
1.97
3.30
1.1
1.1
—
—
—
0
0
173
1346
1.39
3.27
5.6
3.7
1.02
1.02
kg/l
0.14
126
891
18
72
2.54
3.23
1.3
1.5
45.41
25.62
ng/l
0.44
18
72
113
816
1.47
3.22
3.0
2.4
2.32
2.34
g/l
0.19
107
753
172
1342
1.38
3.19
1.8
1.5
2.15
2.33
g/l
0.86
135
855
23
104
2.26
3.19
1.9
2.0
3.96
4.71
mmol/24h
0.44
23
90
48
283
1.75
3.18
2.6
2.1
0.07
2.59
estimate
0.48
15
97
27
131
2.11
3.16
2.3
1.9
126.50
131.58
g/l
0.37
18
108
22
98
2.29
3.15
1.3
1.2
—
—
—
0
0
181
1429
1.37
3.11
3.1
3.3
952.77
1023.77
ng/l
0.14
152
1205
38
211
1.85
3.06
2.3
1.8
—
—
—
0
0
223
1823
1.34
3.05
3.7
3.2
2.35
2.36
mmol/l
0.32
206
1682
13
45
2.93
3.03
1.8
1.8
10.35
11.21
%
0.33
13
45
11
31
3.59
3.00
1.0
1.0
795.67
610.27
ng/l
—
6
22
11
31
3.59
3.00
1.0
1.0
261.33
303.59
ng/l
—
6
22
32
172
1.90
2.86
1.7
1.3
11.94
2.54
u/ml
—
7
20
5
6
8.38
2.75
1.0
1.0
—
—
—
0
0
7
14
5.04
2.73
3.0
1.6
—
—
—
0
0
104
766
1.43
2.67
1.6
1.6
—
—
—
0
0
57
370
1.59
2.66
3.0
4.0
4.42
4.64
pmol/l
1.03
51
333
91
658
1.45
2.58
2.9
3.2
9.11
7.41
umol/l
0.27
77
575
116
879
1.39
2.53
3.1
2.5
11.40
13.58
umol/l
3.27
111
810
37
218
1.74
2.50
2.1
1.4
12.23
9.52
u/l
0.36
32
184
22
109
2.05
2.48
5.2
3.0
2.38
2.45
mmol/l
—
9
70
16
70
2.32
2.42
2.4
2.1
—
—
—
0
0
9
27
3.36
2.39
1.0
2.1
—
—
—
0
0
7
17
4.15
2.36
1.3
1.1
—
—
—
0
0
8
23
3.51
2.27
2.3
1.7
100.71
76.24
ug/l
—
8
23
96
718
1.40
2.27
1.9
1.4
—
—
—
0
0
171
1399
1.30
2.24
2.5
2.2
2.87
2.82
mg/l
0.09
156
1214
8
24
3.36
2.18
38.6
37.4
86.75
116.94
ug/l
—
8
18
28
160
1.78
2.12
4.6
9.8
—
—
—
0
0
9
31
2.93
2.07
3.0
2.9
0.44
0.84
index
—
9
31
202
1712
1.26
1.97
3.8
3.4
—
1.00
—
0
5
11
45
2.47
1.93
1.2
1.1
—
—
—
0
0
23
128
1.83
1.91
1.2
1.1
—
—
—
0
0
23
128
1.83
1.91
1.2
1.1
—
—
—
0
0
38
244
1.59
1.91
1.6
1.9
—
—
—
0
0
287
2543
1.23
1.86
15.2
10.9
0.00
0.00
e9/l
0.62
229
2088
38
246
1.58
1.85
3.6
3.3
1.02
1.02
ratio
1.19
32
232
71
527
1.39
1.78
2.3
2.3
29.61
34.74
u/l
0.74
61
438
8
30
2.69
1.72
2.5
2.2
2.31
1.84
umol/l
—
8
25
461
4320
1.24
1.65
5.3
4.4
14.82
14.64
pmol/l
0.77
439
3984
14
69
2.05
1.65
1.4
1.2
—
—
—
0
0
11
49
2.27
1.64
1.0
1.1
99.36
110.49
pmol/l
0.66
11
49
124
1015
1.27
1.60
3.1
2.6
2.45
2.44
mmol/l
0.16
110
919
123
1006
1.27
1.60
1.3
1.3
11.51
13.54
u/ml
0.16
50
404
6
20
3.02
1.58
2.7
3.9
—
—
—
0
0
55
400
1.41
1.57
5.3
4.0
82.19
80.58
ng/l
0.06
48
354
20
115
1.76
1.54
1.9
1.5
0.28
0.35
nmol/l
0.40
15
96
50
359
1.43
1.53
1.7
1.4
28.37
23.67
iu/l
0.38
42
303
309
2800
1.20
1.50
3.8
3.2
118.36
98.51
ug/l
1.05
294
2641
9
38
2.39
1.46
1.7
2.9
588.00
914.66
mg
—
9
38
21
125
1.70
1.45
4.6
2.9
—
—
—
0
0
22
134
1.66
1.40
3.3
2.8
1.40
1.62
mmol/l
0.76
22
129
28
183
1.55
1.36
3.6
3.7
231.00
299.80
mg/l
0.34
14
81
5
17
2.95
1.36
2.8
2.0
38.64
42.29
g/l
—
5
17
93
753
1.27
1.32
1.1
1.2
—
—
—
0
0
37
259
1.45
1.32
1.3
1.6
—
—
—
0
0
6
24
2.51
1.30
1.7
1.3
0.00
0.00
estimate
—
6
24
24
153
1.59
1.30
1.6
1.2
—
—
—
0
0
12
62
1.95
1.28
2.0
3.3
—
—
—
0
0
15
84
1.80
1.27
1.4
1.4
—
—
—
0
0
586
5697
1.35
1.26
16.8
11.5
27.60
26.31
u/l
1.08
580
5569
27
180
1.52
1.22
1.2
1.2
—
—
—
0
0
22
140
1.59
1.21
1.8
1.2
34.20
54.05
u/ml
—
5
15
97
799
1.25
1.21
1.6
1.5
—
—
—
0
0
39
282
1.41
1.19
1.5
1.5
0.32
0.30
mg/l
0.06
19
122
14
236
0.58
1.19
1.1
1.1
1.60
1.54
g/l
0.33
14
236
8
38
2.12
1.18
1.8
1.4
—
—
—
0
0
15
245
0.60
1.14
1.1
1.2
0.79
0.90
g/l
1.39
15
245
36
260
1.41
1.12
1.0
1.1
—
—
—
0
0
41
303
1.38
1.11
1.3
1.6
—
—
—
0
0
7
32
2.20
1.08
1.3
1.4
—
—
—
0
0
578
5627
1.29
1.06
21.8
12.7
—
—
—
0
0
129
1113
1.20
1.04
1.8
1.7
—
—
—
0
0
5
22
2.28
1.03
1.0
1.1
—
—
—
0
0
5
22
2.28
1.03
1.0
1.1
—
—
—
0
0
5
22
2.28
1.03
1.0
1.1
—
—
—
0
0
32
230
1.41
1.03
1.7
1.9
—
—
—
0
0
9
157
0.57
0.99
1.9
1.4
104.89
202.06
pmol/l
—
9
152
238
2168
1.15
0.99
2.2
2.1
—
—
—
0
0
516
4974
1.19
0.98
6.3
6.0
38.85
38.70
mmol/mol
0.15
493
4715
43
328
1.33
0.98
1.3
1.6
—
—
—
0
0
43
328
1.33
0.98
1.3
1.6
—
—
—
0
0
24
165
1.47
0.98
1.2
1.4
225.50
316.26
ug/g
1.45
11
99
0
30
0.00
0.97
0.0
2.2
—
497.37
—
0
19
12
69
1.75
0.97
2.8
3.6
—
—
—
0
0
43
329
1.33
0.96
1.3
1.6
—
—
—
0
0
43
331
1.32
0.93
1.3
1.5
—
—
—
0
0
9
52
1.74
0.92
1.4
2.5
—
—
—
0
0
19
126
1.52
0.92
1.0
1.0
3.05
0.77
u/ml
—
10
54
30
404
0.73
0.92
1.1
1.2
—
—
—
0
0
8
42
1.91
0.88
2.8
2.5
—
—
—
0
0
8
42
1.91
0.88
1.8
2.6
—
—
—
0
0
8
43
1.87
0.87
1.0
1.0
—
—
—
0
0
6
30
2.01
0.87
1.0
1.1
—
—
—
0
0
6
30
2.01
0.87
1.2
1.1
—
—
—
0
0
20
138
1.46
0.82
1.5
1.9
—
—
—
0
0
8
47
1.71
0.81
3.5
3.1
74.65
21.52
mg/l
—
8
34
189
1718
1.14
0.79
1.5
1.6
—
—
—
0
0
0
25
0.00
0.79
0.0
1.1
—
0.97
—
0
17
5
24
2.09
0.74
2.4
1.5
134.48
189.53
mmol/24h
—
5
24
21
150
1.41
0.74
1.0
1.1
2.24
3.33
u/ml
0.24
12
80
12
76
1.59
0.72
1.8
1.4
—
84.24
—
0
7
9
57
1.59
0.71
1.3
1.2
—
—
—
0
0
15
101
1.50
0.70
1.0
1.0
0.03
0.48
u/ml
—
6
32
7
41
1.71
0.70
1.4
1.0
—
—
—
0
0
7
43
1.63
0.67
1.1
1.2
—
—
—
0
0
42
340
1.25
0.66
1.6
1.7
—
—
—
0
0
55
460
1.21
0.65
7.4
3.8
—
—
—
0
0
123
1103
1.14
0.64
1.4
1.3
40.83
29.62
iu/ml
0.34
38
324
24
181
1.34
0.63
1.5
1.5
—
—
—
0
0
5
30
1.67
0.61
1.0
1.4
0.66
0.49
e9/l
—
5
30
12
80
1.51
0.60
1.0
1.1
1.36
1.47
g/l
0.43
12
72
198
1838
1.11
0.58
3.7
3.3
7.78
7.88
mmol/l
0.10
177
1580
8
53
1.51
0.58
1.4
1.2
—
—
—
0
0
24
184
1.32
0.58
1.5
1.6
—
—
—
0
0
60
513
1.19
0.58
1.6
1.4
—
—
—
0
0
15
106
1.42
0.58
7.5
3.0
5.73
8.48
pmol/l
1.41
15
106
6
35
1.72
0.57
1.3
1.4
65.67
73.34
umol/l
—
6
35
18
132
1.37
0.57
1.0
1.1
0.42
1.81
u/ml
1.24
11
70
44
521
0.83
0.53
1.6
1.7
3.28
3.45
mmol/l
0.39
25
364
23
178
1.30
0.53
1.3
2.1
1.93
4.35
iu/l
—
8
77
69
604
1.16
0.52
1.5
1.4
—
—
—
0
0
38
315
1.22
0.51
2.6
2.3
1621.19
4255.69
u/l
0.91
16
137
6
40
1.50
0.51
1.5
1.8
—
—
—
0
0
10
68
1.48
0.47
1.4
1.3
—
—
nmol/l
—
0
0
7
48
1.46
0.47
1.9
1.9
6.23
6.58
mmol/l
—
7
36
73
648
1.14
0.46
1.8
1.4
—
—
—
0
0
7
50
1.40
0.45
1.0
1.1
—
—
—
0
0
58
658
0.87
0.44
1.3
1.4
—
—
—
0
0
17
131
1.30
0.42
1.0
1.0
10.50
6.46
u/ml
—
8
74
5
32
1.57
0.42
1.2
1.2
33.36
34.27
nmol/l
—
5
26
54
473
1.15
0.42
1.3
1.3
118.36
149.65
u/ml
0.22
24
191
8
59
1.36
0.41
3.9
2.5
3.94
3.99
mmol/l
—
8
59
8
59
1.36
0.41
3.9
2.5
1.19
1.19
mmol/l
—
8
59
8
59
1.36
0.41
3.9
2.5
105.25
105.85
mmol/l
—
8
59
0
17
0.00
0.40
0.0
1.1
—
0.69
—
0
10
11
80
1.38
0.38
1.4
1.3
0.49
0.57
nmol/l
0.43
11
73
21
170
1.24
0.37
2.5
2.9
—
—
—
0
0
141
1318
1.09
0.37
5.1
5.0
3.75
2.19
ug/l
0.41
134
1192
14
107
1.31
0.37
1.1
1.1
—
—
—
0
0
55
488
1.14
0.37
3.8
4.4
4.17
15.50
ug/l
0.68
42
396
5
37
1.35
0.37
1.0
1.2
6.60
8.81
mm/h
—
5
37
5
37
1.35
0.37
2.8
1.7
11.00
35.46
%
—
5
26
72
652
1.12
0.35
1.7
1.8
—
—
—
0
0
15
117
1.29
0.35
1.1
1.1
—
—
—
0
0
91
836
1.10
0.35
2.7
2.6
119.21
110.63
ug/g
0.15
75
668
516
5071
1.09
0.34
6.4
5.4
1.84
1.87
mu/l
0.14
495
4737
11
84
1.31
0.30
1.9
1.6
—
—
—
0
0
64
699
0.91
0.29
1.3
1.3
—
—
—
0
0
8
67
1.20
0.26
1.8
2.0
32.88
32.94
pg
—
8
67
10
77
1.30
0.26
1.4
1.8
—
—
—
0
0
479
4718
1.06
0.23
28.1
18.2
333.29
332.71
g/l
0.72
474
4697
13
106
1.23
0.23
1.0
1.1
5.76
8.59
u/ml
—
7
43
5
39
1.28
0.23
9.4
13.7
0.66
0.64
mmol/l
—
5
39
5
40
1.25
0.22
1.2
1.1
—
—
—
0
0
7
95
0.73
0.22
1.1
1.3
82.27
32.49
u/l
—
7
81
10
79
1.27
0.22
1.7
1.8
13.20
13.17
%
—
10
79
0
11
0.00
0.21
0.0
1.3
—
1.72
—
0
11
169
1625
1.05
0.21
3.6
3.5
101.75
48.72
mg/l
0.95
110
1055
173
1665
1.05
0.21
4.2
4.1
16.09
9.05
mg/mmol
0.62
111
1053
17
145
1.18
0.20
1.2
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
6
50
1.20
0.19
1.2
1.2
—
—
—
0
0
11
90
1.23
0.19
1.1
1.1
—
—
—
0
0
76
804
0.94
0.18
2.9
2.9
0.73
0.74
ug/l
0.04
50
471
8
69
1.16
0.16
1.0
1.1
—
—
—
0
0
49
458
1.07
0.15
2.8
2.4
10.50
13.44
nmol/l
1.81
40
424
28
255
1.10
0.15
1.4
1.3
227.87
247.36
miu/ml
0.11
11
125
16
140
1.15
0.15
1.1
1.1
—
—
—
0
0
30
326
0.92
0.14
1.7
2.6
29.80
87.93
u/ml
0.86
30
312
225
2297
0.97
0.13
1.9
1.9
1.43
1.35
mmol/l
0.69
190
1961
14
122
1.15
0.13
1.0
1.0
7.14
3.41
u/ml
—
8
61
146
1501
0.96
0.13
1.3
1.3
0.78
1.72
u/ml
1.65
41
415
12
104
1.16
0.12
2.1
1.8
—
—
—
0
0
17
152
1.12
0.12
3.0
2.0
220.18
225.82
pmol/l
0.05
17
142
46
486
0.94
0.12
1.3
1.2
—
—
—
0
0
510
5059
1.04
0.12
4.2
4.1
1.38
1.26
mmol/l
2.70
491
4730
537
5332
1.04
0.11
4.9
4.9
4.69
4.68
mmol/l
0.13
515
5032
14
124
1.13
0.11
5.6
4.2
—
—
—
0
0
5
48
1.04
0.09
1.4
1.6
—
—
—
0
0
542
5388
1.03
0.09
5.5
5.4
2.73
2.76
mmol/l
0.36
517
5062
24
223
1.08
0.09
1.7
1.6
3.38
8.35
u/ml
—
8
49
30
318
0.94
0.08
1.2
1.1
—
—
—
0
0
534
5315
1.02
0.06
4.8
4.8
1.47
1.47
mmol/l
0.06
512
4988
24
253
0.95
0.05
2.9
2.2
—
—
—
0
0
594
5948
0.97
0.04
36.2
22.0
7.10
6.67
e9/l
2.89
588
5845
594
5948
0.97
0.04
36.0
21.9
4.46
4.53
e12/l
3.00
587
5848
25
239
1.05
0.04
1.2
1.2
—
—
—
0
0
594
5945
0.98
0.02
36.2
22.0
259.50
253.27
e9/l
1.40
589
5861
11
116
0.95
0.01
1.6
2.4
96.08
136.45
ug/min
—
5
70
20
206
0.97
0.00
2.5
1.9
29.95
40.09
nmol/l
2.64
20
200
511
5099
1.01
0.00
5.0
4.8
5.88
5.87
mmol/l
0.08
488
4736
17
170
1.00
0.00
1.4
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
0.20
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
88
0.91
-0.00
1.8
1.3
93.43
73.58
mu/l
—
8
81
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.9
—
—
—
0
0
5
59
0.85
-0.00
1.4
1.2
1.29
1.68
nmol/l
—
5
54
0
6
0.00
-0.00
0.0
6.5
—
0.30
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_MENINGOTH and mortality.

Females

Parameter HR [95% CI] p-value
G6_MENINGOTH 2.298 [1.88, 2.8] < 0.001
Birth year 0.993 [0.98, 1.0] 0.112

During the follow-up period (1.1.1998 — 31.12.2019), 318 out of 1695 females with G6_MENINGOTH died.

Males

Parameter HR [95% CI] p-value
G6_MENINGOTH 2.392 [1.93, 2.96] < 0.001
Birth year 0.988 [0.98, 1.0] 0.026

During the follow-up period (1.1.1998 — 31.12.2019), 335 out of 1631 males with G6_MENINGOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_MENINGOTH.

N-year risk Females Males
1 0.192% 0.399%
5 1.228% 2.535%
10 3.051% 6.679%
15 5.931% 12.873%
20 10.511% 21.46%

Relationships between endpoints

Index endpoint: G6_MENINGOTH – Other meningitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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