connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.
Other localized connective tissue disorders
DOID EFO Endpoint Browser PheWeb
L12_LOCALDCONNECTISSUEOTH
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
795 |
4. Check minimum number of eventsNone |
795 |
5. Include endpoints |
816 |
6. Filter based on genotype QC (FinnGen only) |
734 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L80-L99
- Name in latin
- Aliae morbositates localisatae textus connectivi
Similar endpoints
↥List of similar endpoints to
Other localized connective tissue disorders
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4269 | 3191 | 1056 |
| Only index persons | 3949 | 2982 | 967 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.09 | 0.03 |
| Only index persons | 0.09 | 0.11 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 53.91 | 55.68 | 48.45 |
| Only index persons | 53.10 | 55.18 | 46.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 734 | 581 | 153 |
| Unadjusted period prevalence (%) | 0.18 | 0.21 | 0.07 |
| Median age at first event (years) | 56.78 | 57.05 | 55.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 767
- Matched controls
- 7670
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
18.7
307.7
311
270
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
6185.2
307.7
545
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
28.3
115.0
79
31
D07AD01
ATC
clobetasol; topical
4.7
84.6
265
775
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
16.5
82.1
71
47
L94.2
ICD-10 Finland
Calcinosis cutis
+∞
79.6
75
*
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
30.3
76.5
51
18
L94.9
ICD-10 Finland
Localized connective tissue disorder, unspecified
767.1
72.4
70
*
D07AC01
ATC
betamethasone; topical
3.7
71.2
431
1957
P01BA02
ATC
hydroxychloroquine; oral
5.4
68.3
157
351
L04AX03
ATC
methotrexate; systemic
4.7
62.9
172
443
L94.8
ICD-10 Finland
Other specified localized connective tissue disorders
+∞
55.9
53
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.5
55.8
274
1057
E0000UV, ,
ATC
3.2
54.2
452
2374
XX9XE
NOMESCO Finland
Other ultrasound examination
20.6
53.2
41
21
L04AA06
ATC
mycophenolic acid; systemic
13.3
52.6
51
41
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
116.0
50.5
54
5
TQW80
NOMESCO Finland
Local dermatologic skincare
11.1
46.0
50
48
D07AC13
ATC
mometasone; topical
2.9
44.1
324
1541
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
13.0
43.0
42
34
TK800
NOMESCO Finland
Hemodialysis
13.1
42.1
41
33
C08CA05
ATC
nifedipine; systemic
5.3
42.1
90
186
L94.1
ICD-10 Finland
Linear scleroderma
+∞
41.0
39
*
L04AA01
ATC
[U] ciclosporin
13.2
40.3
39
31
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.6
40.1
153
492
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
12.8
39.5
39
32
XQ848
NOMESCO Finland
Dermatological photography
7.3
39.1
59
86
L04AX01
ATC
azathioprine; systemic
5.8
35.4
68
127
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.8
34.5
83
189
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
4.1
33.1
99
267
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
9.9
32.6
38
40
M34.1
ICD-10 Finland
CR(E)ST syndrome
35.1
31.2
40
12
I73.0
ICD-10 Finland
Raynaud syndrome
7.9
30.0
42
56
S97
ICPC
Chronic ulcer skin
4.6
28.5
72
170
L04AD01
ATC
ciclosporin; systemic
8.5
27.6
36
44
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.2
27.1
58
119
M34.0
ICD-10 Finland
Progressive systemic sclerosis
145.1
26.8
28
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.1
25.2
72
187
70100
ICD-8 Finland
Other hypertrophic and atrophic conditions of the skin, Seleroderma circumscriptum NUD
+∞
25.1
24
*
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
258.1
24.8
25
*
D07AB08
ATC
desonide; topical
3.0
24.3
124
468
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
24.2
417
2716
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
26.4
24.1
33
13
A11CC03
ATC
alfacalcidol; systemic
6.7
23.7
38
59
D02AX
ATC
Other emollients and protectives
5.7
23.6
45
83
D02AE01
ATC
carbamide; topical
3.7
23.5
79
230
A46
ICD-10 Finland
Erysipelas
2.7
22.9
138
569
H02AB06
ATC
prednisolone; systemic
2.1
22.8
413
2722
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
123.7
22.7
24
*
E000001, ,
ATC
2.4
22.1
199
991
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.9
21.7
112
424
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
+∞
20.9
20
*
M13.9
ICD-10 Finland
Arthritis, unspecified
3.2
20.7
86
287
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
42.9
20.6
25
6
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.2
19.8
54
135
N18.8
ICD-10 Finland
Other chronic renal failure
7.1
19.2
29
42
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
18.6
264
1561
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
25.8
18.3
25
10
Z49.1
ICD-10 Finland
Extracorporeal dialysis
19.9
18.3
27
14
J01FF01
ATC
clindamycin; systemic
2.1
17.9
238
1369
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.6
17.5
59
172
NHQ40
NOMESCO Finland
Amputation of toe
19.8
17.0
25
13
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
6.6
16.7
27
42
196
Kela drug reimbursment
Paricalcitol and cinacalcet
35.9
16.7
21
6
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
16.6
99
403
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
23.7
16.5
23
10
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.9
16.4
84
315
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
5.3
16.4
33
64
C03CA01
ATC
furosemide; systemic
2.0
16.0
236
1401
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
16.0
323
2130
A12AA04
ATC
calcium carbonate; oral
12.6
15.9
28
23
D05AX02
ATC
calcipotriol; topical
4.2
15.7
43
108
V03AE02
ATC
sevelamer; oral
26.9
15.7
21
8
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.6
15.4
93
380
L84
ICD-10 Finland
Corns and callosities
4.7
15.3
36
80
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.2
15.3
64
214
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.3
15.1
59
189
XPX04
NOMESCO Finland
Angioscopy
46.0
15.1
18
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.4
15.1
110
492
S18
ICPC
Laceration/cut
1.8
14.9
387
2741
H02AB04
ATC
methylprednisolone; systemic
2.3
14.9
132
643
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.5
14.9
100
431
L01BA01
ATC
methotrexate; systemic
3.9
14.4
43
115
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.3
14.1
54
171
B03XA02
ATC
darbepoetin alfa; parenteral
5.3
14.0
28
54
D07AB02
ATC
hydrocortisone butyrate; topical
1.9
13.9
254
1605
137
Kela drug reimbursment
Uraemia requiring dialysis
20.5
13.8
20
10
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
142.4
13.5
14
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
13.4
118
573
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.5
13.3
26
49
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.7
13.3
73
284
127
Kela drug reimbursment
Transplant complication
9.9
13.3
26
27
L93.0
ICD-10 Finland
Discoid lupus erythematosus
40.8
13.2
16
*
E000002, ,
ATC
2.3
13.2
103
475
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
13.3
13.0
22
17
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.9
12.8
193
1142
M04AA01
ATC
allopurinol; systemic
2.4
12.6
95
430
V03AE03
ATC
lanthanum carbonate; oral
71.1
12.6
14
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.3
12.6
49
157
N03AX16
ATC
[U] pregabalin
1.9
12.5
199
1198
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
12.5
299
2039
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
4.4
12.3
31
73
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
18.4
12.1
18
10
R4190
NOMESCO Finland
Nutritional therapy
3.3
11.8
45
142
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
4.5
11.8
29
67
L91.0
ICD-10 Finland
Hypertrophic scar
30.5
11.7
15
5
L95.8
ICD-10 Finland
Other vasculitis limited to skin
66.0
11.6
13
*
L89
ICD-10 Finland
Decubitus ulcer and pressure area
19.3
11.6
17
9
V03AE01
ATC
polystyrene sulfonate; oral
11.3
11.6
21
19
J01MA02
ATC
ciprofloxacin; systemic
1.7
11.5
295
2037
L95.0
ICD-10 Finland
Livedoid vasculitis
+∞
11.5
11
*
L94.3
ICD-10 Finland
Sclerodactyly
+∞
11.5
11
*
E000006, ,
ATC
2.6
11.4
70
288
R4120
NOMESCO Finland
Occupational therapy
2.6
11.4
67
270
Z2221
NOMESCO Finland
Medical doctor
1.8
11.3
222
1419
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
5.2
11.3
23
45
H02AB07
ATC
prednisone; oral
2.1
11.2
120
628
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
11.1
281
1930
WW200
NOMESCO Finland
Immunization
4.8
11.0
25
54
M34
ICD-10 Finland
Systemic sclerosis
44.0
10.9
13
*
WX203
NOMESCO Finland
Infraclavicular plexus blockade
4.1
10.8
30
76
Z49.2
ICD-10 Finland
Other dialysis
21.8
10.7
15
7
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
60.9
10.6
12
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
4.6
10.5
25
56
H05BX01
ATC
cinacalcet; oral
14.5
10.5
17
12
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
14.5
10.5
17
12
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.7
10.5
33
92
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
+∞
10.4
10
*
ZXE00
NOMESCO Finland
One hour or less
1.7
10.4
298
2108
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.9
10.4
31
83
R06AE07
ATC
cetirizine; oral
1.7
10.4
363
2702
N18.0
ICD-10 Finland
End-stage renal disease
16.3
10.4
16
10
A28
ICPC
Limited function/disability NOS
1.9
10.3
146
841
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
10.3
93
455
L92.0
ICD-10 Finland
Granuloma annulare
23.7
10.3
14
6
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
13.3
10.2
17
13
Z3226
NOMESCO Finland
Physiotherapist
1.9
10.0
150
879
J01DB01
ATC
cefalexin; oral
1.9
10.0
640
5566
SPAT1262
SPAT
Handing over of treatment supplies
1.9
9.9
132
744
Z94.0
ICD-10 Finland
Kidney transplant status
10.8
9.8
18
17
L88
ICPC
Rheumatoid/seropositive arthritis
2.9
9.8
45
159
XQ845
NOMESCO Finland
Dermatoscopy
4.4
9.6
24
56
R06AX27
ATC
desloratadine; oral
1.7
9.5
237
1609
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
17.8
9.4
14
8
NG4AA
NOMESCO Finland
Lower leg X-ray examination
3.3
9.4
35
109
L94.5
ICD-10 Finland
Poikiloderma vasculare atrophicans
+∞
9.4
9
*
B05DB
ATC
Hypertonic solutions
22.0
9.4
13
6
TK810
NOMESCO Finland
Hemofiltration
22.0
9.4
13
6
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
9.3
355
2676
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.0
9.3
111
602
M79.6
ICD-10 Finland
Pain in limb
1.6
9.3
363
2753
QDA10
NOMESCO Finland
Incision of skin of lower limb
13.9
9.2
15
11
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.8
9.1
47
177
NH3EA
NOMESCO Finland
Feet X-ray examination with load
4.1
9.1
25
63
E000007, ,
ATC
2.6
9.1
53
213
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.7
9.0
47
178
B07.9
ICD-10 Finland
Verruca simplex
3.2
9.0
35
112
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
7.6
9.0
20
27
A07AA02
ATC
nystatin; oral
2.5
8.9
57
240
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
4.7
8.9
20
43
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
8.7
8.8
18
21
R4110
NOMESCO Finland
Physiotherapy
1.7
8.8
220
1490
TQW40
NOMESCO Finland
Remowal of suture of skin
2.4
8.8
63
279
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.7
8.7
182
1173
M35.1
ICD-10 Finland
Other overlap syndromes
14.2
8.7
14
10
UJF32
NOMESCO Finland
Coloscopy
1.7
8.7
199
1317
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
4.6
8.6
20
44
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.9
8.6
39
137
A02BC02
ATC
pantoprazole; systemic
1.6
8.6
526
4401
ZXC50
NOMESCO Finland
Cryotherapy
3.6
8.6
28
80
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
16.5
8.6
13
8
NGQ20
NOMESCO Finland
Amputation of lower leg
16.5
8.6
13
8
Z49.0
ICD-10 Finland
Preparatory care for dialysis
16.5
8.6
13
8
H3603, E103,
ICD-10 Finland
16.5
8.6
13
8
H02AB09
ATC
hydrocortisone; systemic
3.9
8.6
25
66
S21
ICPC
Skin texture symptom/complaint
1.8
8.6
130
763
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
8.6
62
276
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
3.6
8.5
27
76
N02AX02
ATC
tramadol; systemic, rectal
1.6
8.5
319
2384
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.1
8.4
83
419
L03.9
ICD-10 Finland
Cellulitis, unspecified
4.5
8.4
20
45
QBA99
NOMESCO Finland
Other local destruction of skin of trunk
12.9
8.4
14
11
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
4.1
8.4
23
58
S29
ICPC
Skin symptom/complaint other
1.7
8.4
165
1046
3AC01, ,
NOMESCO Finland
10.9
8.3
15
14
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.6
8.3
48
192
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
7.2
8.3
19
27
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
14.7
8.2
13
9
B05DA
ATC
Isotonic solutions
14.7
8.2
13
9
B36.0
ICD-10 Finland
Pityriasis versicolor
4.8
8.1
18
38
N03AX12
ATC
[U] gabapentin; oral
1.8
8.1
133
798
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
8.1
117
675
CKC12
NOMESCO Finland
Photocoagulation of retina
3.0
8.1
36
125
ZZA00
NOMESCO Finland
Split skin graft
3.7
8.1
25
69
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.3
8.0
61
277
ZX120
NOMESCO Finland
Intravenous
2.1
8.0
76
379
C08CA02
ATC
felodipine; oral
2.2
8.0
72
352
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
3.8
8.0
24
65
L71.8
ICD-10 Finland
Other rosacea
4.1
7.8
21
52
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.0
7.8
35
122
M25.5
ICD-10 Finland
Pain in joint
1.6
7.8
270
1968
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
7.8
104
585
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
3.2
7.8
31
101
L30.8
ICD-10 Finland
Other specified dermatitis
3.2
7.8
31
101
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
7.8
174
1141
D07XC01
ATC
betamethasone; topical
2.0
7.7
88
469
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
45.4
7.7
9
*
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
45.4
7.7
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
7.7
189
1269
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
12.0
7.6
13
11
TK820
NOMESCO Finland
Peritoneal dialysis
25.3
7.6
10
*
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
25.3
7.6
10
*
C08CA01
ATC
amlodipine; oral
1.6
7.6
281
2079
A10AB05
ATC
insulin aspart; parenteral
2.2
7.5
60
279
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.8
7.4
130
795
WXQ10
NOMESCO Finland
Psoralen - Ultraviolet A therapy with systemic sensitivisation
80.8
7.4
8
*
7101A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic sclerosis[SCLERODERMA]
80.8
7.4
8
*
A02BC05
ATC
esomeprazole; systemic
1.5
7.4
313
2381
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
7.3
166
1090
WX213
NOMESCO Finland
Lower leg blockade
9.5
7.3
14
15
L94
ICD-10 Finland
Other localized connective tissue disorders
+∞
7.3
7
*
L88
ICD-10 Finland
Pyoderma gangrenosum
+∞
7.3
7
*
E000003, ,
ATC
2.7
7.3
40
156
J01MA12
ATC
levofloxacin; systemic
1.7
7.3
132
815
L50.9
ICD-10 Finland
Urticaria, unspecified
2.7
7.3
37
139
J04BA02
ATC
dapsone; oral
15.9
7.2
11
7
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.7
7.2
22
60
Z3231
NOMESCO Finland
Registered nurse
1.6
7.0
196
1355
R60.0
ICD-10 Finland
Localized oedema
1.8
7.0
102
590
D05AX52
ATC
calcipotriol, combinations; topical
2.5
7.0
43
178
L04AD02
ATC
tacrolimus; systemic
7.6
6.9
15
20
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
6.9
275
2057
L57.0
ICD-10 Finland
Actinic keratosis
2.0
6.9
80
429
M10.0
ICD-10 Finland
Idiopathic gout
3.2
6.9
26
82
D64.9
ICD-10 Finland
Anaemia, unspecified
2.0
6.9
74
387
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
6.8
203
1424
205
Kela drug reimbursment
Chronic hypertension
1.6
6.8
175
1186
RJ412, ,
NOMESCO Finland
40.4
6.8
8
*
L17
ICPC
Foot/toe symptom/complaint
1.5
6.7
241
1760
SPAT1255
SPAT
Intravenous administration of medicine
2.3
6.7
49
219
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
22.7
6.7
9
*
PF1BT
NOMESCO Finland
Extensive PTA of arteries of knee, lower leg and ankle
22.7
6.7
9
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.1
6.6
62
307
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
3.5
6.6
22
64
321
Kela drug reimbursment
Paricalcitol and cinacalcet
8.8
6.6
13
15
GD1AD
NOMESCO Finland
Thorax CT examination
2.3
6.5
51
235
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.2
6.5
25
80
J01FA06
ATC
roxithromycin; oral
1.5
6.5
301
2318
A10AC01
ATC
insulin (human); parenteral
2.1
6.5
58
283
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.1
6.4
63
318
NFQ20
NOMESCO Finland
Amputation of femur
14.5
6.4
10
7
RJ411, ,
NOMESCO Finland
14.5
6.4
10
7
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
4.1
6.4
17
42
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
6.4
87
493
M10.9
ICD-10 Finland
Gout, unspecified
2.4
6.3
44
193
QXA05
NOMESCO Finland
Skin division, unspecified location
18.2
6.3
9
5
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
+∞
6.3
6
*
L94.4
ICD-10 Finland
Gottron papules
+∞
6.3
6
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
7.1
6.2
14
20
D03BA02
ATC
collagenase; topical
26.9
6.2
8
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
3.7
6.2
19
52
WX402
NOMESCO Finland
General anaesthesia
1.6
6.2
169
1158
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.6
6.2
20
57
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
5.4
6.2
17
32
J01EA01
ATC
trimethoprim; systemic
1.5
6.2
210
1513
B01AB10
ATC
tinzaparin; parenteral
1.8
6.1
88
507
A10AB01
ATC
insulin (human); parenteral
2.9
6.1
27
94
R22.3
ICD-10 Finland
Localized swelling, mass and lump, upper limb
3.1
6.1
24
78
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.1
6.1
24
78
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
3.0
6.0
26
89
K29.7
ICD-10 Finland
Gastritis, unspecified
2.7
6.0
32
123
SBA00
NOMESCO Finland
Microbiological examinations
3.0
6.0
25
84
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
165
172
11.95
147.04
1.4
1.2
13.39
9.78
u/ml
—
11
10
193
298
8.32
125.71
2.4
1.7
4.54
6.57
iu/ml
0.72
42
56
180
281
8.06
115.59
1.4
1.3
0.33
1.84
u/ml
—
9
16
156
224
8.49
107.37
1.5
1.2
50.73
19.16
u/ml
—
13
10
152
216
8.53
105.47
1.5
1.2
7.45
11.28
u/ml
0.22
27
31
151
215
8.50
104.57
1.5
1.2
9.09
2.58
u/ml
0.96
20
20
91
87
11.73
84.68
1.4
1.3
42.20
116.60
u/ml
—
12
5
118
168
8.12
81.00
1.5
1.2
22.94
58.60
u/ml
1.02
12
16
83
74
12.46
80.76
1.3
1.2
—
—
—
0
0
60
61
10.59
53.11
1.3
1.2
—
—
—
0
0
63
69
9.86
52.86
1.3
1.1
—
—
—
0
0
60
63
10.25
51.89
1.3
1.2
—
—
—
0
0
60
64
10.09
51.30
1.3
1.2
—
—
—
0
0
60
64
10.09
51.30
1.3
1.2
—
—
—
0
0
604
3977
3.44
45.16
13.3
9.5
3.92
4.03
e9/l
0.72
553
3455
42
35
12.64
42.23
1.2
1.1
—
—
—
0
0
148
470
3.66
39.48
2.4
2.5
20.98
23.35
au/ml
0.12
13
40
136
428
3.65
36.62
1.3
1.3
17.19
43.72
au/ml
—
7
36
231
1101
2.57
29.20
4.7
2.3
12.40
12.94
umol/l
0.55
212
1018
219
1025
2.59
28.68
4.7
2.3
2.28
2.35
g/l
1.06
198
944
204
943
2.58
27.25
4.8
2.3
21.83
22.29
%
0.19
188
881
36
45
8.34
27.07
2.3
1.4
5.50
7.32
u/l
0.56
28
40
306
1712
2.31
26.63
3.5
2.6
343.66
328.43
umol/l
1.70
276
1510
137
531
2.92
25.65
3.7
2.9
11.41
10.45
g/l
1.23
123
493
345
2088
2.19
24.19
3.3
2.0
156.58
199.15
u/l
0.52
330
1986
134
538
2.81
23.38
3.1
2.9
65.57
67.48
g/l
1.64
123
493
455
3102
2.15
23.07
16.2
10.9
0.00
0.00
e9/l
1.49
389
2515
651
5177
2.70
22.33
7.7
4.4
14.45
12.11
mm/h
3.05
626
4830
112
424
2.92
21.72
2.3
1.8
1.37
1.40
g/l
0.04
101
392
653
5276
2.60
20.28
12.5
7.8
78.79
78.25
u/l
0.13
633
4979
466
3348
2.00
18.80
3.6
2.5
77.73
78.41
nmol/l
0.21
423
3029
177
892
2.28
18.77
15.6
4.5
1.12
1.04
mmol/l
2.31
167
821
505
3761
2.00
18.01
4.9
3.9
13.06
4.46
estimate
0.28
111
787
376
2540
1.94
17.83
6.1
3.8
110.95
123.86
e6/l
0.07
260
1726
68
216
3.36
17.68
3.3
2.1
554.28
240.83
ug/l
0.74
63
203
498
3712
1.97
17.45
4.9
3.9
0.00
0.00
estimate
0.50
105
768
461
3372
1.92
16.80
4.7
3.0
110.51
98.76
ug/l
0.99
430
3138
504
3798
1.95
16.78
5.0
4.0
0.07
0.42
estimate
0.40
107
751
45
112
4.21
16.61
1.4
1.2
4.71
1.74
u/ml
0.59
24
38
251
1508
1.99
16.52
1.9
1.5
2.52
2.34
g/l
0.29
152
885
283
1788
1.92
15.95
3.0
2.2
2.83
2.86
mg/l
0.08
250
1529
472
3519
1.89
15.78
15.6
6.8
1.22
1.22
mmol/l
0.02
408
3039
21
9
23.94
15.17
1.1
1.0
—
—
—
0
0
306
2011
1.87
15.08
3.7
3.0
2411.94
1011.17
ng/l
1.37
265
1686
42
107
4.09
15.04
1.4
1.2
4.32
3.31
u/ml
0.33
25
48
107
474
2.46
15.01
4.2
3.2
324.96
179.27
ng/l
0.57
98
438
126
603
2.30
14.85
9.3
3.3
131.68
76.33
ng/l
4.67
115
532
71
259
2.92
14.59
2.7
2.0
3.09
3.01
g/l
0.29
65
237
73
272
2.86
14.44
2.7
2.0
3.56
3.77
g/l
0.55
67
251
73
273
2.85
14.34
2.7
2.0
4.10
4.32
g/l
1.14
67
251
73
273
2.85
14.34
2.7
2.0
7.41
7.47
g/l
0.09
67
251
42
111
3.95
14.31
1.4
1.3
—
—
—
0
0
416
3038
1.81
14.27
8.4
4.5
35.59
35.91
g/l
0.59
396
2867
194
1114
1.99
14.22
2.2
1.8
—
—
—
0
0
42
112
3.91
14.14
1.3
1.2
—
—
—
0
0
42
112
3.91
14.14
1.3
1.2
410.00
324.62
titre
—
8
13
67
241
2.95
14.12
3.0
2.3
1.53
0.71
g/l
0.60
61
212
286
1876
1.84
13.92
4.9
3.0
0.41
0.42
e6/l
0.01
211
1333
22
16
14.12
13.30
1.1
1.1
—
—
—
0
0
230
1427
1.87
13.25
1.4
1.3
16.36
29.65
iu/ml
3.50
63
456
65
239
2.88
13.16
2.7
2.0
10.28
10.23
g/l
0.02
59
216
425
3176
1.76
12.99
14.7
6.0
1.22
1.22
mmol/l
0.34
395
2930
112
539
2.26
12.95
20.7
6.1
12.27
8.94
mmol/l
4.58
107
516
236
1492
1.84
12.73
3.7
2.5
5.04
6.94
e6/l
1.63
214
1356
134
698
2.11
12.70
4.0
4.7
248.89
251.60
u/l
0.05
128
664
58
205
2.98
12.61
2.9
2.0
0.00
0.00
g/l
-0.00
53
181
317
2195
1.76
12.54
5.0
3.1
25.14
74.87
e6/l
0.91
248
1636
562
4586
1.84
12.41
6.4
4.7
1081.30
1562.12
e6/l
—
10
66
193
1157
1.89
12.24
4.1
2.8
0.78
1.12
e6/l
1.06
103
577
348
2487
1.73
12.21
3.7
3.3
2.35
2.36
mmol/l
0.41
329
2252
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
49
160
3.20
12.18
9.8
2.9
0.38
0.38
iu/ml
0.00
27
85
58
211
2.89
11.98
1.4
1.6
0.06
0.09
iu/ml
—
8
36
123
640
2.10
11.64
3.0
2.1
0.22
0.21
g/l
0.41
114
601
54
193
2.93
11.51
3.9
3.8
3.91
2.51
ratio
0.33
29
111
57
211
2.84
11.41
3.9
3.9
68.55
70.62
mg/l
0.02
47
183
53
189
2.94
11.35
1.7
1.3
—
—
—
0
0
56
211
2.78
10.85
4.0
3.9
48.04
52.76
mg/l
0.10
47
182
21
22
9.78
10.80
1.5
1.1
8.85
9.06
ug/l
0.06
21
22
462
3641
1.68
10.70
7.1
6.2
9.99
10.89
umol/l
1.55
439
3471
258
1754
1.71
10.47
1.4
1.3
1.25
1.65
u/ml
0.27
63
451
65
272
2.52
10.24
2.6
2.1
1.52
1.53
g/l
0.01
59
242
97
487
2.14
10.03
2.1
1.5
—
—
—
0
0
140
803
1.91
9.99
2.1
1.8
—
—
—
0
0
121
665
1.97
9.78
4.6
3.2
—
—
—
0
0
328
2407
1.63
9.75
4.4
3.2
6.76
7.12
mmol/l
0.75
274
2046
284
2018
1.65
9.56
1.9
1.7
19.89
21.05
nmol/l
0.59
241
1699
181
1139
1.77
9.55
6.4
3.2
0.80
0.82
mmol/l
0.74
170
1081
399
3089
1.61
9.42
2.5
2.1
100.20
97.39
pmol/l
0.57
215
1543
388
3000
1.59
9.09
17.3
12.5
1.24
1.20
inr
0.75
325
2447
142
842
1.84
9.08
2.1
1.8
—
—
—
0
0
116
650
1.92
8.83
3.0
2.4
28.78
37.35
u/l
1.77
96
539
120
682
1.90
8.75
2.5
2.0
335.36
389.12
nmol/l
2.26
114
639
48
188
2.66
8.66
2.3
2.8
—
—
—
0
0
46
180
2.65
8.32
1.5
1.3
—
—
—
0
0
47
187
2.61
8.22
4.2
2.5
212.45
192.82
%
0.64
42
182
49
201
2.54
8.06
2.4
2.3
12.43
11.78
mg/l
0.16
44
188
197
1324
1.66
8.01
1.4
1.3
7.53
12.79
u/ml
0.69
78
484
77
388
2.09
7.87
1.9
1.7
—
—
—
0
0
165
1070
1.69
7.66
4.6
2.9
4.21
3.39
e6/l
0.32
77
485
628
5567
1.71
7.46
5.7
4.8
14.77
14.81
pmol/l
0.16
591
5126
238
1705
1.57
7.36
7.0
3.7
94.32
93.54
%
0.20
233
1663
293
2201
1.54
7.32
3.4
2.5
55.17
65.14
u/l
1.91
269
2031
43
174
2.56
7.29
1.7
1.5
—
—
—
0
0
301
2293
1.51
6.96
5.3
4.0
24.39
7.90
mg/mmol
2.02
180
1348
43
180
2.47
6.81
1.7
1.5
—
—
—
0
0
277
2081
1.52
6.80
4.9
3.9
0.00
0.01
estimate
1.15
97
735
477
4010
1.50
6.71
8.6
4.7
6.76
6.55
mmol/l
1.27
464
3774
700
6462
1.95
6.51
24.7
14.4
79.08
81.56
ml/min/173m2
2.10
668
5955
188
1312
1.57
6.39
5.2
3.8
75.14
356.29
ng/l
3.45
149
984
35
138
2.61
6.28
1.7
1.6
—
—
—
0
0
6
0
+∞
6.26
5.0
0.0
—
—
—
0
0
32
121
2.72
6.22
12.9
4.5
1523.89
420.08
iu/ml
—
9
12
37
152
2.51
6.12
2.5
1.9
120.89
128.30
g/l
1.35
19
120
66
346
1.99
6.08
4.9
2.9
1.69
2.07
mmol/l
0.34
48
261
31
117
2.72
6.06
1.2
1.4
—
—
—
0
0
145
963
1.62
6.04
2.0
2.3
160.78
112.55
ug/g
0.68
125
752
20
59
3.45
5.89
1.3
1.5
—
—
—
0
0
44
200
2.27
5.84
1.5
1.2
—
—
—
0
0
728
6852
2.23
5.83
31.9
17.1
3.96
3.95
mmol/l
0.59
716
6702
29
108
2.75
5.82
1.2
1.1
—
—
—
0
0
393
3234
1.44
5.80
3.9
2.7
—
—
estimate
—
0
0
30
114
2.70
5.79
1.9
1.6
—
—
—
0
0
715
6688
2.02
5.78
28.8
14.4
22.57
22.19
mg/l
0.11
632
5432
727
6842
2.20
5.77
31.2
16.9
139.52
139.69
mmol/l
0.92
715
6709
19
55
3.52
5.76
1.9
1.7
—
—
—
0
0
16
41
3.96
5.73
1.3
1.2
—
—
—
0
0
742
7046
2.63
5.72
20.0
11.7
25.35
24.93
u/l
0.37
723
6845
161
1113
1.57
5.64
1.8
1.7
1239.74
1192.87
nmol/l
0.20
129
833
39
171
2.35
5.62
2.9
3.0
1.93
2.25
index
0.11
14
83
48
230
2.16
5.62
2.3
1.8
—
—
—
0
0
744
7079
2.70
5.61
33.7
19.1
84.61
72.40
umol/l
5.78
739
6997
45
211
2.20
5.56
1.9
1.7
—
—
—
0
0
37
161
2.36
5.43
2.3
1.6
—
—
—
0
0
222
1667
1.47
5.21
4.0
2.2
—
—
—
0
0
5
0
+∞
5.21
4.2
0.0
—
—
—
0
0
121
796
1.62
5.21
4.3
2.5
5.84
6.81
umol/l
0.53
111
692
32
134
2.45
5.12
1.3
1.4
—
—
—
0
0
345
2818
1.41
5.08
4.7
3.8
0.01
0.03
estimate
0.84
92
638
23
82
2.86
5.02
1.3
1.3
—
—
—
0
0
24
88
2.78
4.98
1.6
1.4
—
—
—
0
0
193
1423
1.48
4.94
2.7
2.6
2.47
2.46
mmol/l
1.05
178
1277
23
83
2.83
4.91
1.3
1.3
—
—
—
0
0
23
83
2.83
4.91
1.3
1.3
—
—
—
0
0
690
6438
1.71
4.85
7.1
5.8
1.94
1.87
mu/l
0.95
650
5970
19
62
3.12
4.82
1.9
1.7
—
—
—
0
0
34
151
2.31
4.79
1.6
1.7
—
—
—
0
0
37
171
2.22
4.76
1.8
1.5
11548.91
15091.10
e6/l
0.24
23
114
22
80
2.80
4.64
1.2
1.3
—
—
—
0
0
22
80
2.80
4.64
1.2
1.3
—
—
—
0
0
22
81
2.77
4.55
1.2
1.3
—
—
—
0
0
109
725
1.59
4.47
11.1
8.3
5.12
5.10
kpa
0.08
104
699
109
725
1.59
4.47
11.1
8.3
11.89
12.26
kpa
0.41
104
700
292
2366
1.38
4.32
4.7
3.0
29.36
30.67
u/l
0.42
278
2236
513
4547
1.39
4.31
4.3
3.2
57.50
44.75
u/l
1.32
482
4268
10
16
6.32
4.30
3.0
1.6
0.58
0.61
mmol/l
—
10
16
34
159
2.19
4.27
1.2
1.4
—
—
—
0
0
28
121
2.36
4.22
1.8
1.3
150.43
154.17
au/ml
0.06
14
35
14
41
3.46
4.20
1.4
1.8
509.67
540.73
e6/l
—
9
30
98
646
1.59
4.18
14.8
3.1
1.73
1.91
mmol/l
0.19
92
550
17
57
3.03
4.14
1.5
1.3
1820.30
1847.67
e6/l
—
10
36
18
64
2.86
3.98
4.2
4.8
7.14
7.13
mmol/l
0.00
12
53
63
375
1.74
3.97
14.8
9.2
23.44
24.40
mmol/l
1.35
63
366
77
490
1.64
3.79
1.5
1.2
464.80
206.14
u/ml
0.54
69
448
204
1589
1.39
3.75
2.2
1.8
0.94
1.18
mg/l
1.28
162
1222
105
721
1.53
3.75
11.4
8.4
-0.05
1.03
mmol/l
1.60
93
605
10
20
5.05
3.69
2.1
1.6
—
—
—
0
0
10
20
5.05
3.69
2.1
1.6
—
—
—
0
0
22
91
2.46
3.66
1.1
1.1
—
—
—
0
0
251
2033
1.35
3.59
4.0
3.4
0.01
0.07
estimate
0.64
86
624
10
21
4.81
3.56
2.1
1.6
—
—
—
0
0
22
93
2.41
3.51
1.5
1.5
—
—
—
0
0
13
36
3.66
3.51
1.9
1.7
—
—
—
0
0
13
36
3.66
3.51
1.9
1.7
—
—
—
0
0
86
578
1.55
3.39
19.6
7.1
1.17
1.30
mmol/l
0.90
86
568
13
42
3.13
3.38
1.9
1.5
40.00
22.00
u/ml
—
5
6
174
1343
1.38
3.35
1.5
1.6
—
—
—
0
0
22
96
2.33
3.29
1.0
1.0
1.62
1.87
eliau/ml
—
10
38
44
250
1.81
3.27
1.6
1.7
—
—
—
0
0
38
206
1.89
3.27
1.2
1.3
—
—
—
0
0
474
4237
1.31
3.25
3.3
3.1
—
—
—
0
0
11
29
3.83
3.19
2.0
1.5
—
—
—
0
0
11
29
3.83
3.19
2.0
1.5
—
—
—
0
0
11
29
3.83
3.19
2.0
1.5
—
—
—
0
0
11
29
3.83
3.19
2.0
1.5
—
—
—
0
0
25
118
2.16
3.13
1.5
1.3
—
—
—
0
0
25
118
2.16
3.13
1.5
1.3
—
—
—
0
0
40
224
1.83
3.13
1.5
1.4
242.95
297.76
ug/g
1.00
21
127
12
35
3.47
3.11
2.5
1.9
104.75
46.11
ug/l
0.93
12
35
47
277
1.74
3.11
1.6
1.6
11.08
12.07
u/ml
—
5
54
79
533
1.54
3.07
3.4
2.5
55.62
67.74
ml/min/173m2
1.50
32
239
72
477
1.56
3.04
3.4
3.5
4.34
4.54
pmol/l
1.13
65
429
82
560
1.52
3.02
6.1
3.6
1.24
1.23
mmol/l
0.20
71
482
14
51
2.78
3.00
2.2
1.5
—
—
—
0
0
14
51
2.78
3.00
2.2
1.5
—
—
—
0
0
14
51
2.78
3.00
2.2
1.5
—
—
—
0
0
670
6339
1.45
2.96
8.2
6.2
39.49
38.91
mmol/mol
0.88
635
5944
17
70
2.46
2.89
1.8
1.2
—
—
—
0
0
10
27
3.74
2.88
1.3
1.1
—
—
—
0
0
10
27
3.74
2.88
1.2
1.5
106.40
171.80
mmol/24h
—
10
27
182
1446
1.34
2.88
1.7
1.7
58064963.94
41322758.42
pmol/l
0.11
155
1210
116
861
1.41
2.80
17.2
6.5
103.59
104.02
mmol/l
0.45
116
861
26
131
2.02
2.78
1.3
1.4
—
—
—
0
0
747
7276
2.02
2.57
41.2
22.6
257.49
257.01
e9/l
0.07
735
7143
12
42
2.89
2.55
2.1
1.8
—
—
—
0
0
747
7279
2.01
2.52
42.8
22.9
39.37
40.02
%
2.50
740
7202
747
7279
2.01
2.52
41.1
22.6
4.40
4.46
e12/l
2.81
734
7123
747
7282
1.99
2.47
41.5
22.7
131.50
133.74
g/l
4.15
741
7208
21
103
2.07
2.43
1.3
1.4
—
—
—
0
0
701
6733
1.48
2.41
6.6
5.8
2.58
2.76
mmol/l
6.30
656
6259
293
2532
1.25
2.38
4.2
3.5
51.54
56.12
ng/l
0.06
211
1748
5
8
6.28
2.37
1.0
1.4
—
—
—
0
0
746
7278
1.91
2.31
41.1
22.5
91.38
90.95
fl
1.67
739
7205
689
6605
1.42
2.31
5.8
5.0
1.48
1.53
mmol/l
2.59
645
6125
200
1657
1.28
2.30
5.5
4.0
1.02
1.02
kg/l
0.18
141
1095
341
3006
1.24
2.30
2.2
1.9
1.36
1.33
mmol/l
0.31
278
2549
10
34
2.97
2.28
3.5
3.5
782.60
906.44
u/ml
—
10
34
691
6636
1.42
2.20
5.9
5.1
4.54
4.74
mmol/l
6.75
649
6194
13
54
2.43
2.20
3.0
2.2
—
—
—
0
0
12
48
2.52
2.19
1.4
1.3
197801.00
50654.23
e6/l
—
6
22
19
94
2.05
2.17
1.7
1.4
—
—
—
0
0
660
6296
1.35
2.16
4.8
4.2
1.31
1.26
mmol/l
1.12
617
5789
602
5677
1.28
2.11
34.9
18.4
13.88
13.60
%
5.49
597
5598
8
25
3.22
2.10
1.0
1.2
—
—
—
0
0
5
10
5.02
2.07
1.2
1.3
—
—
—
0
0
678
6504
1.37
2.05
5.8
5.1
5.91
5.88
mmol/l
0.25
635
5980
10
38
2.65
2.01
1.2
1.2
—
—
—
0
0
10
38
2.65
2.01
1.2
1.2
—
—
—
0
0
10
38
2.65
2.01
1.8
1.3
1.91
1.92
umol/l
—
10
31
22
120
1.86
1.94
2.6
2.3
266.06
62.58
ug/min
0.46
14
73
8
27
2.98
1.94
1.3
1.1
—
—
—
0
0
8
27
2.98
1.94
1.3
1.1
—
—
—
0
0
5
12
4.19
1.82
1.0
1.0
—
—
—
0
0
7
24
2.93
1.72
1.0
1.0
—
—
—
0
0
14
69
2.05
1.65
1.2
1.1
97.29
109.72
pmol/l
0.64
14
69
12
56
2.16
1.61
1.5
1.4
—
—
—
0
0
22
130
1.71
1.54
1.4
1.3
301.47
221.78
u/ml
0.49
15
74
72
550
1.34
1.52
1.3
1.2
188.01
148.58
u/ml
0.27
26
221
9
37
2.45
1.48
1.4
1.4
89.44
72.95
umol/l
—
9
37
37
252
1.49
1.48
2.3
2.0
0.32
2.06
ug/l
0.94
32
226
13
66
1.99
1.44
1.1
1.2
—
—
—
0
0
17
96
1.79
1.40
1.1
1.1
—
1.10
—
0
5
35
240
1.48
1.37
1.5
1.4
163.46
234.84
miu/ml
1.00
16
114
6
23
2.62
1.37
1.8
1.0
—
—
—
0
0
5
17
2.95
1.36
1.2
1.3
—
—
—
0
0
9
42
2.16
1.34
1.2
1.9
11.43
12.44
umol/l
—
9
36
11
54
2.05
1.33
1.5
1.2
1.21
1.15
promille
0.05
11
43
15
83
1.82
1.32
1.1
1.1
—
—
—
0
0
48
353
1.38
1.31
1.4
1.3
21.19
27.58
iu/l
0.68
37
296
63
484
1.33
1.31
2.4
2.2
24.10
7.43
ug/l
0.58
53
428
9
43
2.11
1.30
2.7
1.6
131.53
93.06
ng/l
—
9
43
8
35
2.30
1.27
3.6
1.6
—
—
—
0
0
32
222
1.46
1.21
2.2
2.0
2.35
4.16
iu/l
1.54
12
89
38
273
1.41
1.20
1.9
2.2
8963.39
6800.28
u/l
0.09
14
122
8
38
2.12
1.18
1.1
1.1
—
—
—
0
0
9
51
1.77
0.94
1.7
1.9
—
—
—
0
0
13
79
1.66
0.88
1.2
1.7
31.62
32.05
pg
0.09
13
79
28
204
1.39
0.86
1.3
1.1
—
—
—
0
0
6
31
1.94
0.84
1.0
1.5
—
—
—
0
0
28
205
1.38
0.84
1.3
1.1
—
—
—
0
0
10
57
1.76
0.84
5.4
2.6
24.20
12.16
index
—
5
32
0
27
0.00
0.77
0.0
2.3
—
41.18
—
0
22
9
53
1.71
0.75
1.3
1.2
0.97
1.35
nmol/l
—
9
48
5
24
2.09
0.74
2.4
1.5
—
—
—
0
0
156
1404
1.14
0.74
1.6
1.4
—
—
—
0
0
12
76
1.59
0.72
3.1
3.6
—
—
—
0
0
16
227
0.70
0.69
1.1
1.1
1.55
1.58
g/l
0.24
16
227
65
549
1.20
0.69
1.7
1.5
—
—
—
0
0
10
61
1.65
0.68
1.2
1.2
2.40
1.04
u/ml
—
5
34
11
69
1.60
0.68
1.2
1.1
—
—
—
0
0
5
27
1.86
0.68
1.0
1.2
12.80
8.74
mm/h
—
5
27
7
42
1.67
0.68
1.4
1.3
—
—
—
0
0
7
118
0.59
0.68
1.0
1.1
—
16.41
—
0
17
17
237
0.71
0.67
1.4
1.1
0.93
0.89
g/l
0.29
17
237
7
44
1.60
0.65
1.3
1.1
—
—
—
0
0
7
44
1.60
0.65
1.4
1.3
—
—
—
0
0
87
760
1.16
0.64
1.5
1.7
1.54
1.43
%
0.65
79
670
5
30
1.67
0.61
1.4
1.1
—
—
—
0
0
5
30
1.67
0.61
1.0
1.2
82.72
144.62
iu/ml
—
5
30
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
85
748
1.15
0.58
8.8
6.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
35
1.72
0.57
1.2
1.2
—
—
—
0
0
6
36
1.67
0.56
1.0
1.1
—
—
—
0
0
19
250
0.75
0.54
1.5
1.5
—
—
—
0
0
6
40
1.50
0.51
1.0
1.0
1783.00
1694.55
miu/ml
—
6
40
83
738
1.14
0.50
2.9
4.1
39.34
24.27
ug/l
0.16
64
606
31
253
1.23
0.49
1.5
1.4
—
—
—
0
0
41
345
1.20
0.49
1.8
1.4
—
—
—
0
0
7
46
1.53
0.48
1.0
1.0
—
—
—
0
0
46
392
1.18
0.48
1.7
1.9
—
—
—
0
0
7
48
1.46
0.47
1.4
1.3
—
—
—
0
0
15
198
0.75
0.45
1.2
1.5
—
—
—
0
0
10
69
1.46
0.44
1.1
1.4
332.40
317.55
mu/l
—
10
55
7
51
1.38
0.44
1.0
1.0
—
—
—
0
0
5
31
1.62
0.43
2.8
4.9
1.20
1.23
%
—
5
31
6
94
0.64
0.42
1.2
1.4
6.96
7.24
mmol/l
—
6
79
5
32
1.57
0.42
6.6
2.5
1.00
0.81
index
—
5
32
30
358
0.83
0.41
1.3
1.6
1032.82
943.86
mu/l
0.28
23
301
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
85
771
1.12
0.40
4.2
4.2
24.35
22.07
%
0.63
50
340
43
376
1.15
0.35
1.7
1.3
—
—
—
0
0
38
329
1.16
0.35
3.0
2.3
10.21
12.81
nmol/l
1.12
32
311
13
99
1.32
0.35
3.8
2.0
170.38
215.15
pmol/l
0.37
13
94
14
108
1.30
0.35
1.4
1.7
—
—
—
0
0
6
47
1.28
0.32
1.5
1.3
—
—
—
0
0
32
277
1.16
0.31
1.3
1.6
0.43
0.27
mg/l
0.86
11
112
11
84
1.31
0.30
3.4
2.5
24.17
24.98
mg/l
—
6
34
59
536
1.11
0.29
1.6
1.7
3.19
3.47
mmol/l
1.29
40
380
67
729
0.91
0.28
1.9
2.0
—
—
—
0
0
64
586
1.10
0.27
3.2
2.9
0.86
0.73
ug/l
0.27
48
349
8
67
1.20
0.26
1.0
1.1
—
—
—
0
0
73
788
0.92
0.26
2.0
2.2
—
—
—
0
0
13
105
1.24
0.25
1.0
1.1
—
2.08
—
0
19
17
201
0.84
0.24
1.2
1.5
1.00
1.17
ratio
—
10
126
17
201
0.84
0.24
1.2
1.5
0.89
1.20
ratio
—
10
126
17
201
0.84
0.24
1.2
1.5
0.81
0.95
ratio
—
10
126
18
153
1.18
0.22
1.2
1.3
3.17
54.74
e6/l
0.71
12
113
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
6.73
—
0
10
0
10
0.00
0.21
0.0
1.2
—
94.80
—
0
10
6
49
1.23
0.20
1.3
1.2
—
—
—
0
0
6
49
1.23
0.20
1.3
1.2
—
—
—
0
0
18
207
0.87
0.19
1.1
1.3
—
—
—
0
0
7
61
1.15
0.17
1.1
1.3
30438.86
139415.17
e6/l
—
7
40
41
379
1.09
0.16
1.1
1.1
—
—
—
0
0
22
196
1.13
0.16
1.5
1.2
—
—
—
0
0
29
265
1.10
0.15
1.6
1.8
3.00
3.20
mg/l
0.10
24
200
90
863
1.05
0.14
5.2
4.9
33.37
32.99
%
0.11
65
561
5
46
1.09
0.09
1.2
1.1
—
—
—
0
0
11
122
0.90
0.07
1.5
1.6
67.61
49.51
ug/l
1.30
11
122
9
87
1.03
0.07
1.0
1.2
—
—
—
0
0
49
475
1.03
0.05
1.9
2.0
—
—
—
0
0
15
142
1.06
0.02
1.0
1.1
0.30
2.63
u/ml
—
9
74
10
106
0.94
0.01
1.8
1.6
—
—
—
0
0
48
486
0.99
0.00
2.1
3.6
27.85
73.29
u/ml
1.09
48
470
12
115
1.04
0.00
1.0
1.0
0.19
1.74
u/ml
—
7
52
17
166
1.02
0.00
1.5
1.7
—
—
—
0
0
72
725
0.99
0.00
1.9
1.9
3.32
3.39
ratio
0.22
53
559
30
302
0.99
0.00
1.9
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
11.66
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
0.63
—
0
8
6
61
0.98
-0.00
1.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
91
0.99
-0.00
1.4
1.4
3.16
2.92
ug/l
—
9
77
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
73
0.96
-0.00
2.9
1.9
13.00
13.22
%
—
7
73
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
59.33
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
14
140
1.00
-0.00
1.6
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
71
0.99
-0.00
1.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_LOCALDCONNECTISSUEOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LOCALDCONNECTISSUEOTH | 1.609 [1.39, 1.87] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 414 out of 2658 females with L12_LOCALDCONNECTISSUEOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LOCALDCONNECTISSUEOTH | 1.885 [1.5, 2.36] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 166 out of 878 males with L12_LOCALDCONNECTISSUEOTH died.
Mortality risk
Mortality risk for people of age
years, who have L12_LOCALDCONNECTISSUEOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.132% | 0.253% |
| 5 | 0.812% | 1.947% |
| 10 | 1.838% | 5.043% |
| 15 | 3.557% | 9.345% |
| 20 | 6.019% | 15.559% |
Relationships between endpoints
↥Index endpoint: L12_LOCALDCONNECTISSUEOTH – Other localized connective tissue disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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