connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
78 |
4. Check minimum number of eventsNone |
78 |
5. Include endpointsNone |
78 |
6. Filter based on genotype QC (FinnGen only) |
73 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L94
- Name in latin
- Calcinosis cutis
Similar endpoints
↥List of similar endpoints to
Calcinosis cutis
based on the number of shared cases.
Similar with more cases:
- Other localized connective tissue disorders
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 288 | 172 | 115 |
| Only index persons | 267 | 159 | 108 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 64.69 | 68.70 | 58.79 |
| Only index persons | 64.73 | 68.91 | 58.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 73 | 44 | 29 |
| Unadjusted period prevalence (%) | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | 63.63 | 65.03 | 61.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 75
- Matched controls
- 750
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L94.2
ICD-10 Finland
Calcinosis cutis
+∞
107.8
75
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
263.5
41.5
39
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
22.6
38.6
35
28
A46
ICD-10 Finland
Erysipelas
14.9
32.0
41
56
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
15.8
28.9
31
32
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
413.2
28.8
27
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
115.6
28.2
29
*
S97
ICPC
Chronic ulcer skin
16.3
28.1
29
28
TK800
NOMESCO Finland
Hemodialysis
137.7
26.7
27
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
78.0
23.9
26
5
A11CC03
ATC
alfacalcidol; systemic
64.8
23.2
26
6
Z49.1
ICD-10 Finland
Extracorporeal dialysis
+∞
23.1
21
*
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
108.4
22.1
23
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
+∞
21.9
20
*
C03CA01
ATC
furosemide; systemic
9.7
21.2
53
149
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
45.7
20.9
25
8
196
Kela drug reimbursment
Paricalcitol and cinacalcet
+∞
20.8
19
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
22.9
20.4
30
21
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
8.6
19.8
39
84
A49.9
ICD-10 Finland
Bacterial infection, unspecified
9.6
18.6
28
44
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
232.8
18.4
18
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
22.7
17.9
26
17
NHQ40
NOMESCO Finland
Amputation of toe
216.1
17.3
17
*
V03AE02
ATC
sevelamer; oral
216.1
17.3
17
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
24.5
17.0
24
14
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
21.4
16.9
25
17
A12AA04
ATC
calcium carbonate; oral
77.6
16.6
18
*
M04AA01
ATC
allopurinol; systemic
8.1
16.5
29
54
137
Kela drug reimbursment
Uraemia requiring dialysis
200.0
16.1
16
*
B03XA02
ATC
darbepoetin alfa; parenteral
58.2
15.9
18
*
ZXD05
NOMESCO Finland
Urgent procedure
6.8
15.7
44
130
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
17.8
14.7
23
18
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
66.7
14.5
16
*
N18.8
ICD-10 Finland
Other chronic renal failure
66.7
14.5
16
*
I50.9
ICD-10 Finland
Heart failure, unspecified
7.0
14.3
29
62
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.1
14.2
28
58
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
27.6
14.2
19
9
V03AE03
ATC
lanthanum carbonate; oral
+∞
14.0
13
*
H05BX01
ATC
cinacalcet; oral
+∞
14.0
13
*
TPH04
NOMESCO Finland
Cathetrisation of vein
6.2
13.9
37
102
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
7.5
13.9
25
47
NG4AA
NOMESCO Finland
Lower leg X-ray examination
24.8
13.8
19
10
SPAT1148
SPAT
Treatment of chronic ulcer or burn
6.7
13.5
28
61
Z49.2
ICD-10 Finland
Other dialysis
+∞
12.9
12
*
205
Kela drug reimbursment
Chronic hypertension
5.6
12.8
41
132
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
56.5
12.4
14
*
L04AA06
ATC
mycophenolic acid; systemic
36.8
12.2
15
5
V03AE01
ATC
polystyrene sulfonate; oral
77.4
12.0
13
*
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
140.7
11.8
12
*
321
Kela drug reimbursment
Paricalcitol and cinacalcet
+∞
11.8
11
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
+∞
11.8
11
*
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
24.9
11.7
16
8
B01AA03
ATC
warfarin; systemic
6.0
11.4
26
61
127
Kela drug reimbursment
Transplant complication
51.6
11.3
13
*
J01FF01
ATC
clindamycin; systemic
5.1
11.2
40
138
WX402
NOMESCO Finland
General anaesthesia
5.3
11.0
32
93
R4190
NOMESCO Finland
Nutritional therapy
13.0
10.8
19
19
J01CF05
ATC
flucloxacillin; systemic
10.8
10.8
21
26
B05DA
ATC
Isotonic solutions
127.0
10.7
11
*
B05DB
ATC
Hypertonic solutions
127.0
10.7
11
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
127.0
10.7
11
*
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
+∞
10.7
10
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.0
10.5
34
107
ZX120
NOMESCO Finland
Intravenous
6.6
10.5
20
39
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.2
10.3
21
44
Z94.0
ICD-10 Finland
Kidney transplant status
63.5
9.9
11
*
WX213
NOMESCO Finland
Lower leg blockade
63.5
9.9
11
*
S18
ICPC
Laceration/cut
5.5
9.9
58
286
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
25.7
9.7
13
6
N18.0
ICD-10 Finland
End-stage renal disease
113.8
9.7
10
*
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
113.8
9.7
10
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
+∞
9.6
9
*
PE1AT
NOMESCO Finland
Femoral artery PTA
+∞
9.6
9
*
TK810
NOMESCO Finland
Hemofiltration
+∞
9.6
9
*
H02AB04
ATC
methylprednisolone; systemic
5.4
9.3
23
57
L28
ICPC
Limited function/disability (L)
4.6
9.3
31
99
R50.9
ICD-10 Finland
Fever, unspecified
5.1
9.3
25
67
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
28.1
9.2
12
5
TPH07
NOMESCO Finland
Cathetrisation of artery
6.0
9.2
19
40
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
11.2
9.1
17
19
C02AC05
ATC
moxonidine; oral
12.4
9.1
16
16
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.8
8.9
55
274
J01MA12
ATC
levofloxacin; systemic
4.7
8.8
27
80
ZZA00
NOMESCO Finland
Split skin graft
31.7
8.8
11
*
XF400
NOMESCO Finland
ECG with 12 standard connections
4.7
8.6
26
76
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
100.9
8.6
9
*
L04AD02
ATC
tacrolimus; systemic
100.9
8.6
9
*
TK820
NOMESCO Finland
Peritoneal dialysis
100.9
8.6
9
*
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
+∞
8.5
8
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.5
8.4
27
83
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
37.9
8.3
10
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
5.6
8.2
18
40
B01AC04
ATC
clopidogrel; oral
4.4
8.0
26
80
M13.9
ICD-10 Finland
Arthritis, unspecified
8.5
7.8
17
25
ZXE00
NOMESCO Finland
One hour or less
3.9
7.8
46
216
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
5.3
7.7
18
42
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
11.2
7.7
14
15
ZXE10
NOMESCO Finland
More than one and less than three hours
3.8
7.6
42
188
QDA10
NOMESCO Finland
Incision of skin of lower limb
88.5
7.6
8
*
PD4CG
NOMESCO Finland
Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
88.5
7.6
8
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
88.5
7.6
8
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
9.6
7.5
15
19
N02AA05
ATC
oxycodone; systemic
4.1
7.5
28
95
A28
ICPC
Limited function/disability NOS
4.1
7.5
29
101
B01AB10
ATC
tinzaparin; parenteral
5.2
7.5
18
43
C08CA01
ATC
amlodipine; oral
3.8
7.5
46
220
C07AB07
ATC
bisoprolol; oral
4.1
7.4
54
288
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
7.4
7
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
7.4
7
*
NGQ20
NOMESCO Finland
Amputation of lower leg
+∞
7.4
7
*
K65.0
ICD-10 Finland
Acute peritonitis
33.6
7.3
9
*
A10AC01
ATC
insulin (human); parenteral
7.5
7.3
17
28
L04AX03
ATC
methotrexate; systemic
5.1
7.3
18
44
WX408
NOMESCO Finland
General anesthesy, balanced
3.8
7.3
34
135
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.2
7.3
25
80
J01MA02
ATC
ciprofloxacin; systemic
3.7
7.2
44
208
WX203
NOMESCO Finland
Infraclavicular plexus blockade
15.8
7.1
11
8
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.9
7.1
18
45
D64.9
ICD-10 Finland
Anaemia, unspecified
5.1
7.0
17
41
WX002
NOMESCO Finland
Sedation and analgesia
3.9
7.0
27
94
L04AA01
ATC
[U] ciclosporin
44.1
6.9
8
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
10.2
6.9
13
15
ZXD10
NOMESCO Finland
Scheduled procedure
3.6
6.9
44
213
M10.0
ICD-10 Finland
Idiopathic gout
11.6
6.8
12
12
R4110
NOMESCO Finland
Physiotherapy
3.5
6.6
35
149
WW200
NOMESCO Finland
Immunization
16.2
6.6
10
7
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
7.5
6.6
15
24
PF1BT
NOMESCO Finland
Extensive PTA of arteries of knee, lower leg and ankle
76.0
6.5
7
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
76.0
6.5
7
*
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
76.0
6.5
7
*
3AC01, ,
NOMESCO Finland
76.0
6.5
7
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.5
6.5
42
202
H02AB06
ATC
prednisolone; systemic
3.6
6.5
49
260
KA1AE
NOMESCO Finland
Kidney ultrasound examination
20.1
6.4
9
5
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
29.4
6.4
8
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
+∞
6.3
6
*
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
+∞
6.3
6
*
103
Kela drug reimbursment
Diabetes, insulin-treated
3.5
6.3
32
132
WX212
NOMESCO Finland
Femoral plexus blockade
14.2
6.3
10
8
N02AX02
ATC
tramadol; systemic, rectal
3.4
6.3
45
230
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
3.5
6.2
30
120
E0000UV, ,
ATC
3.3
6.2
43
215
WX320
NOMESCO Finland
Spinalanesthesy
3.5
6.2
31
127
A10AB05
ATC
insulin aspart; parenteral
6.3
6.1
16
31
A10AE04
ATC
insulin glargine; parenteral
4.7
6.1
16
41
ZXA05
NOMESCO Finland
Left side
3.4
6.1
31
128
M10.9
ICD-10 Finland
Gout, unspecified
6.7
6.1
15
27
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.2
6.1
19
56
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.4
6.0
30
122
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
53
93
17.02
34.84
33.7
5.5
1.30
1.11
mmol/l
2.45
53
87
41
78
10.39
23.84
3.0
1.7
—
—
—
0
0
41
80
10.10
23.25
2.9
1.6
—
—
—
0
0
46
108
9.43
21.91
3.0
1.7
—
—
—
0
0
38
73
9.52
21.64
31.9
4.8
1.89
1.78
mmol/l
0.06
38
57
29
45
9.88
19.56
34.5
5.8
24.14
24.53
mmol/l
0.26
29
45
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
14
27.60
19.05
15.5
3.9
0.30
0.49
iu/ml
—
13
7
32
59
8.72
18.57
42.5
11.3
1.20
1.19
mmol/l
0.03
32
59
33
64
8.42
18.27
8.5
3.5
—
—
—
0
0
23
34
9.31
15.87
1.7
1.7
3.58
4.96
iu/ml
—
5
9
21
14
20.26
14.14
5.1
1.4
4.82
1.72
ratio
—
11
7
25
47
7.48
13.88
3.8
1.5
—
—
—
0
0
23
23
13.89
13.19
1.8
1.4
0.23
0.22
g/l
0.15
23
23
25
50
7.00
13.03
23.4
12.7
23.76
25.02
mmol/l
0.82
25
50
19
12
20.68
12.99
2.6
1.2
—
—
—
0
0
12
0
+∞
12.87
7.3
0.0
5.55
—
mmol/l
—
12
0
22
40
7.37
12.50
2.7
1.5
—
—
—
0
0
38
118
5.50
12.26
8.4
3.5
0.45
0.89
e6/l
0.94
21
57
56
244
6.11
11.92
11.3
3.3
—
—
—
0
0
26
61
5.99
11.39
2.7
3.5
32.33
28.18
u/l
0.34
21
50
21
42
6.56
10.79
28.9
12.8
23.81
24.94
mmol/l
0.57
21
42
65
339
7.88
10.77
62.8
8.6
1.20
1.21
mmol/l
0.98
55
290
35
112
4.98
10.65
8.8
3.8
0.98
3.40
e6/l
1.28
18
52
31
95
4.86
9.84
48.0
8.9
100.19
103.48
mmol/l
2.44
31
95
48
206
4.69
9.82
11.5
3.2
0.38
0.32
e6/l
0.16
39
145
13
6
25.74
9.73
1.7
1.3
—
—
—
0
0
58
293
5.32
9.44
26.2
4.9
31.47
35.73
g/l
6.63
58
278
13
7
22.04
9.31
1.0
1.3
—
—
—
0
0
40
157
4.32
9.06
9.5
2.8
—
—
—
0
0
18
37
6.09
8.89
41.3
3.8
0.57
0.59
%
0.08
18
37
16
20
9.84
8.11
4.8
8.7
2.76
1.69
mg/l
1.94
16
15
14
14
11.99
7.93
2.2
1.2
129.40
144.00
au/ml
—
5
5
14
14
11.99
7.93
2.2
1.2
—
—
—
0
0
14
14
11.99
7.93
1.1
1.3
9.88
2.00
u/ml
—
8
6
12
9
15.55
7.69
1.6
1.0
—
—
—
0
0
12
9
15.55
7.69
1.6
1.0
—
—
—
0
0
14
15
11.17
7.68
2.3
1.6
—
—
—
0
0
45
212
3.81
7.49
5.9
2.3
123.73
233.85
u/l
0.71
45
203
19
50
4.75
7.05
5.7
3.6
33.89
68.67
ml/min/173m2
—
9
21
11
9
14.05
6.83
4.8
3.3
—
—
—
0
0
55
311
3.88
6.64
9.2
3.1
—
—
estimate
—
0
0
44
219
3.44
6.45
6.7
4.2
88.24
8.30
mg/mmol
2.26
37
131
9
5
20.14
6.43
1.0
1.0
—
—
—
0
0
6
0
+∞
6.33
5.0
0.0
494.00
—
umol/l
—
6
0
17
36
5.79
6.09
43.6
3.8
1.00
1.32
%
0.63
17
36
9
6
16.77
6.07
2.2
2.3
2970.33
1368.83
mg
—
9
6
11
13
9.69
5.79
1.5
1.7
—
—
—
0
0
9
7
14.37
5.74
1.1
1.6
—
—
—
0
0
9
7
14.37
5.74
1.1
1.6
—
—
—
0
0
9
7
14.37
5.74
1.1
1.4
—
—
—
0
0
9
7
14.37
5.74
1.1
1.6
—
—
—
0
0
12
17
8.17
5.70
2.1
2.8
—
—
—
0
0
13
21
7.24
5.68
2.0
1.2
—
—
—
0
0
11
14
8.99
5.57
2.0
1.6
—
—
—
0
0
11
14
8.99
5.57
2.0
1.6
—
—
—
0
0
8
5
17.64
5.54
2.0
1.2
—
—
—
0
0
42
221
3.05
5.32
5.9
3.5
13298.53
1130.87
ng/l
1.87
36
189
5
0
+∞
5.26
4.8
0.0
—
—
—
0
0
10
13
8.67
5.03
1.4
1.1
—
—
—
0
0
9
10
10.03
4.93
1.1
1.4
—
—
—
0
0
9
11
9.11
4.71
1.1
1.4
—
—
—
0
0
10
15
7.50
4.64
1.3
1.1
—
—
—
0
0
7
6
12.68
4.37
1.6
1.5
—
—
—
0
0
12
26
5.29
4.28
1.7
1.6
34.42
40.93
u/l
0.45
12
21
7
8
9.49
3.86
2.1
2.0
—
—
—
0
0
38
215
2.56
3.85
13.2
3.6
27.58
32.89
u/l
0.79
38
200
9
16
6.23
3.79
2.6
1.9
—
—
—
0
0
9
17
5.86
3.63
1.8
2.3
—
—
—
0
0
13
37
4.03
3.62
2.9
1.3
—
—
—
0
0
8
13
6.74
3.60
1.3
1.4
—
—
—
0
0
7
12
6.30
3.09
1.3
1.4
—
—
—
0
0
7
12
6.30
3.09
9.6
1.2
21.14
8.57
pmol/l
—
7
12
5
5
10.58
3.02
1.0
1.0
—
—
—
0
0
16
69
2.68
2.71
2.5
2.0
300.06
386.78
nmol/l
1.05
16
64
7
16
4.71
2.54
1.0
1.1
—
—
—
0
0
6
12
5.33
2.45
1.2
1.5
—
—
—
0
0
43
296
2.06
2.39
3.4
2.0
99.65
95.87
pmol/l
0.27
29
130
7
19
3.95
2.21
1.1
1.8
—
—
—
0
0
48
364
1.89
1.82
7.5
3.9
0.00
0.00
estimate
—
9
78
6
18
3.53
1.78
2.0
1.1
—
—
—
0
0
48
368
1.85
1.72
7.8
4.0
0.00
0.00
estimate
—
9
79
6
19
3.34
1.70
2.0
1.1
—
—
—
0
0
6
19
3.34
1.70
2.7
1.6
—
—
—
0
0
6
20
3.17
1.61
2.7
1.9
—
—
—
0
0
48
374
1.79
1.57
7.9
4.0
0.00
0.00
estimate
—
9
77
7
28
2.65
1.49
2.0
1.4
—
—
—
0
0
50
398
1.77
1.48
3.9
3.1
—
—
—
0
0
7
29
2.56
1.43
2.0
4.4
8.00
347.33
u/ml
—
7
24
5
17
3.07
1.38
1.6
1.3
—
—
—
0
0
21
138
1.72
1.20
1.3
1.4
13.33
33.01
iu/ml
—
8
46
18
122
1.63
0.91
1.2
1.4
3.99
8.56
u/ml
—
9
50
32
253
1.46
0.81
7.2
4.1
54.48
33.17
ng/l
1.08
27
183
61
549
1.60
0.79
111.2
19.7
15.17
13.64
%
8.64
61
543
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
5
77
0.62
0.38
55.6
8.2
—
—
—
0
0
6
44
1.39
0.35
1.0
1.2
—
66.44
u/ml
—
0
18
7
97
0.69
0.33
2.0
1.4
—
—
—
0
0
18
210
0.81
0.26
5.3
3.3
0.00
0.00
estimate
—
7
63
6
80
0.73
0.25
1.7
2.3
—
—
—
0
0
12
146
0.79
0.25
2.6
5.1
34.64
21.88
%
—
7
72
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
26
277
0.91
0.10
6.7
3.8
0.00
0.02
estimate
—
8
65
5
48
1.04
0.09
1.6
1.3
—
—
—
0
0
6
72
0.82
0.08
1.7
2.1
—
—
—
0
0
20
208
0.95
0.02
6.0
4.2
0.00
0.00
estimate
—
6
76
12
124
0.96
0.00
1.4
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.7
—
0.50
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
16.05
—
0
8
Mortality – FinRegistry
↥Association
Association between endpoint L12_CALCINOSISCUTIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_CALCINOSISCUTIS | 4.812 [1.96, 11.82] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.559 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 132 females with L12_CALCINOSISCUTIS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_CALCINOSISCUTIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.542% | No data |
| 5 | 3.161% | No data |
| 10 | 7.911% | No data |
| 15 | 14.384% | No data |
| 20 | 23.902% | No data |
Relationships between endpoints
↥Index endpoint: L12_CALCINOSISCUTIS – Calcinosis cutis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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