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Localized scleroderma [morphea]

DOID EFO Endpoint Browser PheWeb

L12_LOCALSCLERODERMA

localised scleroderma: Localized scleroderma is the skin localized form of scleroderma (see this term) characterized by fibrosis of the skin causing cutaneous plaques or strips.

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L94.0
  • Hospital discharge: ICD-9 — 7010A
  • Hospital discharge: ICD-8 — 70100
  • Cause of death: ICD-10 — L94.0
  • Cause of death: ICD-9 — 7010A
  • Cause of death: ICD-8 — 70100

2 out of 7 registries used, show all original rules.

602

4. Check minimum number of events

None

602

5. Include endpoints

None

602

6. Filter based on genotype QC (FinnGen only)

542

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L94
Name in latin
Scleroderma circumscriptum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3160 2461 682
Only index persons 2953 2322 631
Unadjusted period prevalence (%)
Whole population 0.06 0.07 0.02
Only index persons 0.07 0.09 0.02
Median age at first event (years)
Whole population 52.33 54.73 43.53
Only index persons 51.81 54.19 43.06

-FinnGen-

Key figures

All Female Male
Number of individuals 542 448 94
Unadjusted period prevalence (%) 0.14 0.16 0.04
Median age at first event (years) 56.38 56.82 54.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
566
Matched controls
5660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
4503599627370496.0
307.7
545
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
17.9
229.1
224
200
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
22.2
88.3
67
34
D07AD01
ATC
clobetasol; topical
5.7
83.9
219
568
D07AC01
ATC
betamethasone; topical
4.3
63.6
340
1474
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.1
55.4
221
766
L04AX03
ATC
methotrexate; systemic
4.7
46.7
126
322
P01BA02
ATC
hydroxychloroquine; oral
5.0
44.8
111
264
E0000UV, ,
ATC
3.4
43.9
346
1794
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
116.1
40.3
43
*
XQ848
NOMESCO Finland
Dermatological photography
9.0
39.2
50
60
D07AC13
ATC
mometasone; topical
3.0
35.1
246
1153
TQW80
NOMESCO Finland
Local dermatologic skincare
10.0
30.0
35
37
70100
ICD-8 Finland
Other hypertrophic and atrophic conditions of the skin, Seleroderma circumscriptum NUD
+∞
25.2
24
*
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.7
24.8
61
142
L94.1
ICD-10 Finland
Linear scleroderma
+∞
24.1
23
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.3
24.1
103
355
D02AE01
ATC
carbamide; topical
4.2
22.3
63
163
M34.1
ICD-10 Finland
CR(E)ST syndrome
30.5
22.1
29
10
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
+∞
22.0
21
*
C08CA05
ATC
nifedipine; systemic
4.3
21.5
58
145
I73.0
ICD-10 Finland
Raynaud syndrome
6.8
18.9
30
46
D07AB08
ATC
desonide; topical
3.0
18.9
93
346
L94.9
ICD-10 Finland
Localized connective tissue disorder, unspecified
196.2
18.6
19
*
E000001, ,
ATC
2.4
17.8
152
745
M34.0
ICD-10 Finland
Progressive systemic sclerosis
98.2
17.7
19
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.5
17.5
64
198
XX9XE
NOMESCO Finland
Other ultrasound examination
19.4
17.5
26
14
XPX04
NOMESCO Finland
Angioscopy
92.9
16.7
18
*
D05AX02
ATC
calcipotriol; topical
4.9
16.1
36
77
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
+∞
15.7
15
*
D02AX
ATC
Other emollients and protectives
5.2
15.2
32
65
XQ845
NOMESCO Finland
Dermatoscopy
6.7
13.7
22
34
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
12.4
191
1158
H02AB06
ATC
prednisolone; systemic
1.9
12.4
288
2001
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
12.1
285
1985
E000002, ,
ATC
2.5
11.4
79
347
L30.8
ICD-10 Finland
Other specified dermatitis
4.4
11.4
29
69
L04AA06
ATC
mycophenolic acid; systemic
8.6
11.4
24
29
M13.9
ICD-10 Finland
Arthritis, unspecified
2.9
10.9
54
200
D07AB02
ATC
hydrocortisone butyrate; topical
1.9
10.8
191
1202
L04AX01
ATC
azathioprine; systemic
3.8
10.8
33
90
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.5
10.7
71
306
L04AA01
ATC
[U] ciclosporin
9.0
10.4
21
24
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
8.6
9.6
20
24
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
22.1
9.4
13
6
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
7.6
9.0
20
27
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.9
8.9
146
889
QBA99
NOMESCO Finland
Other local destruction of skin of trunk
16.6
8.6
13
8
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
8.5
142
870
L04AD01
ATC
ciclosporin; systemic
6.9
8.4
20
30
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
4.8
8.4
19
41
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
+∞
8.4
8
*
L93.0
ICD-10 Finland
Discoid lupus erythematosus
33.9
8.1
10
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.9
8.0
37
132
B36.0
ICD-10 Finland
Pityriasis versicolor
7.1
7.8
18
26
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
15.3
7.7
12
8
L92.0
ICD-10 Finland
Granuloma annulare
18.7
7.6
11
6
L91.0
ICD-10 Finland
Hypertrophic scar
25.4
7.6
10
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
4.3
7.5
19
45
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
4.0
7.5
21
54
SPAT1262
SPAT
Handing over of treatment supplies
1.9
7.4
95
531
7101A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic sclerosis[SCLERODERMA]
81.1
7.4
8
*
ZXC50
NOMESCO Finland
Cryotherapy
3.8
7.4
22
59
WXQ10
NOMESCO Finland
Psoralen - Ultraviolet A therapy with systemic sensitivisation
+∞
7.3
7
*
L94.8
ICD-10 Finland
Other specified localized connective tissue disorders
+∞
7.3
7
*
M34
ICD-10 Finland
Systemic sclerosis
30.4
7.2
9
*
E000007, ,
ATC
2.6
7.1
41
165
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.2
7.0
59
282
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
4.5
7.0
17
39
E000006, ,
ATC
2.3
6.8
50
225
R06AE07
ATC
cetirizine; oral
1.6
6.8
265
2014
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
4.4
6.8
17
40
S99
ICPC
Skin disease other
3.8
6.7
20
54
L71.8
ICD-10 Finland
Other rosacea
4.2
6.6
17
41
H02AB04
ATC
methylprednisolone; systemic
1.9
6.6
85
477
N03AX16
ATC
[U] pregabalin
1.7
6.4
138
901
B07.9
ICD-10 Finland
Verruca simplex
3.1
6.4
26
86
UJF32
NOMESCO Finland
Coloscopy
1.7
6.4
146
969
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
6.7
6.4
15
23
SBA00
NOMESCO Finland
Microbiological examinations
3.5
6.3
21
61
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
3.9
6.3
18
47
R06AX27
ATC
desloratadine; oral
1.6
6.3
177
1239
L01BA01
ATC
methotrexate; systemic
3.1
6.3
25
82
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
6.2
262
2018
D05AX52
ATC
calcipotriol, combinations; topical
2.7
6.2
33
128
J01FF01
ATC
clindamycin; systemic
1.7
6.1
150
1013
NH3EA
NOMESCO Finland
Feet X-ray examination with load
3.8
6.1
18
48
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.9
6.1
80
450
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.7
6.1
32
123
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.2
6.1
50
237
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
5.6
6.0
16
29
A02BC02
ATC
pantoprazole; systemic
1.6
6.0
385
3241

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
159
190
11.25
129.66
1.4
1.2
—
—
—
0
0
132
137
12.26
118.44
1.4
1.2
14.92
11.82
u/ml
—
8
8
280
751
6.40
106.85
1.8
1.4
1021.18
535.17
titre
2.19
85
174
142
219
8.32
92.67
1.4
1.3
0.27
2.04
u/ml
—
7
14
144
237
7.81
88.46
2.1
1.8
4.53
7.05
iu/ml
0.75
31
47
119
174
8.39
80.79
1.5
1.2
8.35
6.50
u/ml
0.11
20
26
121
181
8.23
80.54
1.5
1.2
62.48
21.96
u/ml
—
10
7
118
174
8.30
79.48
1.5
1.2
10.86
2.61
u/ml
0.99
16
16
90
137
7.62
58.28
1.5
1.2
28.96
70.92
u/ml
—
8
13
131
367
4.34
42.90
2.5
2.5
20.98
23.77
au/ml
0.13
13
31
122
331
4.42
41.59
1.3
1.3
18.38
41.32
au/ml
—
6
29
426
2653
3.45
36.99
8.5
6.0
1.84
1.96
e9/l
1.25
393
2310
421
2615
3.38
36.47
8.5
6.0
0.04
0.04
e9/l
0.09
384
2218
418
2601
3.32
35.77
8.5
6.0
0.55
0.56
e9/l
0.32
380
2211
42
45
10.00
35.76
1.4
1.2
—
—
—
0
0
40
41
10.42
35.14
1.4
1.2
—
—
—
0
0
425
2711
3.28
34.00
8.7
6.3
0.19
0.18
e9/l
0.19
390
2341
444
2918
3.42
33.48
9.9
9.7
3.76
3.99
e9/l
1.98
403
2520
382
2397
2.83
29.52
8.6
6.1
0.75
0.70
%
0.54
369
2216
382
2407
2.81
29.10
8.6
6.1
8.57
8.64
%
0.22
370
2239
380
2403
2.77
28.47
8.6
6.0
2.87
2.75
%
0.48
368
2232
384
2443
2.78
28.39
8.6
6.0
29.17
28.42
%
0.76
373
2302
378
2408
2.72
27.49
8.4
6.0
56.28
57.04
%
0.70
372
2285
299
1710
2.59
27.06
8.4
5.8
—
—
—
0
0
43
73
6.29
24.69
1.4
1.2
—
—
—
0
0
338
2297
2.17
17.63
12.7
10.7
0.00
0.00
e9/l
1.01
285
1849
251
1525
2.16
17.46
2.9
2.0
159.09
159.77
u/l
0.01
239
1446
96
387
2.78
16.73
3.4
3.0
10.70
10.40
g/l
0.28
85
361
150
789
2.23
14.56
2.5
2.2
13.62
12.92
umol/l
0.58
137
730
28
54
5.40
14.04
2.3
2.0
—
—
—
0
0
197
1169
2.05
13.88
5.7
4.5
—
—
—
0
0
79
317
2.73
13.79
1.9
1.8
1.31
1.39
g/l
0.14
70
293
207
1259
2.02
13.56
2.9
2.5
330.78
325.11
umol/l
0.35
184
1105
21
13
16.71
13.54
1.5
1.2
8.85
9.56
ug/l
0.18
21
13
476
3894
2.40
13.33
9.6
7.6
76.62
77.48
u/l
0.19
461
3674
140
740
2.19
13.29
2.4
2.2
2.38
2.37
g/l
0.02
126
682
370
2769
1.97
12.93
4.7
3.9
16.86
6.15
estimate
0.27
86
569
189
1134
2.00
12.71
1.7
1.6
2.47
2.30
g/l
0.19
111
666
128
681
2.14
11.82
2.5
2.2
23.63
22.12
%
0.63
116
635
362
2739
1.89
11.65
4.7
3.9
0.00
0.00
estimate
-0.00
81
556
366
2798
1.87
11.18
4.8
3.9
0.10
0.01
estimate
0.73
82
541
102
512
2.21
10.84
2.0
1.5
—
—
—
0
0
334
2503
1.82
10.65
3.6
3.0
93.05
93.83
ug/l
0.04
310
2320
175
1078
1.90
10.57
1.5
1.3
14.98
30.42
iu/ml
4.07
48
333
264
1857
1.79
10.31
4.6
3.8
123.57
113.59
e6/l
0.04
182
1262
203
1321
1.84
10.26
1.4
1.3
0.81
1.71
u/ml
1.12
52
342
328
2466
1.79
10.14
3.1
2.5
78.92
79.01
nmol/l
0.02
295
2219
285
2065
1.77
9.94
2.0
2.1
—
—
—
0
0
230
1608
1.72
8.79
5.0
3.7
7.40
7.40
ph
0.18
163
1146
211
1443
1.74
8.71
3.3
3.0
694.70
980.58
ng/l
1.48
181
1221
28
81
3.58
8.47
1.5
1.1
3.94
3.60
u/ml
0.10
16
35
292
2196
1.68
8.38
4.1
3.5
6.33
6.22
ph
0.90
156
1217
8
0
+∞
8.35
1.1
0.0
—
—
—
0
0
332
2586
1.69
8.31
8.2
6.5
1.22
1.22
mmol/l
0.56
290
2237
83
425
2.12
8.31
4.9
4.7
0.35
0.04
%
0.50
20
102
82
419
2.12
8.25
4.7
4.3
0.62
0.61
%
0.00
21
122
167
1083
1.77
8.22
2.7
2.4
5.36
6.93
e6/l
0.87
150
991
291
2200
1.66
8.08
5.2
4.3
36.19
35.99
g/l
0.26
277
2076
192
1301
1.72
8.07
2.6
2.2
2.83
2.92
mg/l
0.19
169
1107
26
74
3.63
8.06
2.4
3.3
3.78
4.05
e9/l
0.31
26
74
478
4148
1.98
8.04
5.9
4.8
14.75
14.78
pmol/l
0.09
449
3818
77
392
2.12
7.81
2.5
3.0
67.04
67.65
g/l
0.27
71
363
68
331
2.20
7.72
4.6
3.2
134.62
171.27
ng/l
0.41
61
306
84
447
2.03
7.57
5.0
4.3
0.87
0.99
%
0.10
23
138
97
546
1.94
7.45
1.6
1.5
—
—
—
0
0
12
9
13.59
7.41
1.2
1.3
—
—
—
0
0
247
1819
1.64
7.41
2.9
3.3
2.36
2.36
mmol/l
0.25
232
1645
80
422
2.04
7.38
5.2
4.4
0.05
0.09
%
0.29
19
113
196
1369
1.66
7.20
3.4
3.0
0.38
0.41
e6/l
0.10
141
971
403
3381
1.67
6.89
5.8
4.7
1798.33
1934.24
e6/l
—
6
51
67
340
2.10
6.84
2.6
2.6
—
—
—
0
0
25
78
3.31
6.77
2.0
1.6
0.83
0.68
g/l
0.25
14
71
239
1776
1.60
6.73
3.7
3.2
7.09
7.04
mmol/l
0.06
198
1494
17
41
4.24
6.59
1.4
1.3
6.76
7.01
g/l
0.07
11
34
17
41
4.24
6.59
1.4
1.3
0.31
0.33
g/l
0.18
11
34
17
41
4.24
6.59
1.4
1.3
2.44
2.67
g/l
0.22
11
33
12
12
10.19
6.56
1.3
1.1
28.75
26.58
s
0.53
12
12
104
624
1.82
6.51
1.7
1.4
—
—
—
0
0
17
42
4.14
6.39
1.4
1.3
—
—
—
0
0
218
1600
1.59
6.39
3.7
3.1
25.72
92.53
e6/l
0.89
169
1195
296
2339
1.56
6.23
7.3
5.8
1.22
1.22
mmol/l
0.65
274
2153
28
99
2.92
6.19
2.4
2.9
57.07
57.64
%
0.09
28
99
209
1533
1.58
6.07
5.0
4.0
0.00
0.00
estimate
-0.00
76
533
290
2292
1.54
6.02
2.4
2.1
98.73
96.52
pmol/l
0.34
144
1107
107
664
1.75
5.96
2.6
1.9
—
—
—
0
0
148
1006
1.64
5.87
1.5
1.3
8.67
12.72
u/ml
0.36
59
360
543
5064
2.78
5.86
21.7
16.6
3.94
3.95
mmol/l
0.28
535
4940
40
175
2.38
5.84
1.4
1.2
—
—
—
0
0
265
2065
1.53
5.80
4.6
3.8
0.01
0.02
estimate
0.07
70
453
542
5060
2.68
5.65
21.3
16.5
139.77
139.73
mmol/l
0.11
534
4949
214
1603
1.54
5.55
3.0
2.4
52.98
67.07
u/l
2.19
195
1477
520
4781
2.08
5.50
7.4
5.9
1.94
1.86
mu/l
0.87
491
4434
123
810
1.66
5.49
1.6
1.6
—
—
—
0
0
85
507
1.80
5.40
2.7
2.7
1.67
1.83
%
1.25
75
456
9
8
11.41
5.30
1.7
2.1
—
—
—
0
0
68
381
1.89
5.26
2.4
2.6
62.54
72.43
e9/l
2.31
47
278
171
1235
1.55
5.17
4.4
3.9
—
—
—
0
0
217
1652
1.51
5.13
3.9
3.3
29.02
41.01
mg/l
0.59
127
968
552
5228
3.26
5.07
16.7
11.6
25.35
24.68
u/l
0.60
537
5066
209
1588
1.50
4.95
6.5
6.1
—
—
—
0
0
390
3364
1.51
4.86
3.6
3.1
46.35
42.55
u/l
0.32
365
3166
26
102
2.62
4.78
1.1
1.2
—
—
—
0
0
33
146
2.34
4.73
1.3
1.2
—
826.00
—
0
5
98
633
1.66
4.67
6.6
4.0
1.03
1.04
mmol/l
0.13
89
578
19
64
3.04
4.59
1.3
1.2
—
—
—
0
0
200
1525
1.48
4.58
1.7
1.7
21.11
21.11
nmol/l
0.00
167
1284
108
721
1.62
4.52
2.1
2.3
168.31
108.14
ug/g
0.64
93
554
321
2699
1.44
4.30
5.9
5.9
10.16
10.68
umol/l
0.56
304
2566
62
361
1.81
4.27
1.4
1.4
—
—
—
0
0
215
1682
1.45
4.25
4.6
3.9
6.19
8.07
mg/mmol
0.43
120
952
527
4946
1.95
4.04
20.4
14.1
21.69
21.87
mg/l
0.04
460
4011
60
354
1.78
3.96
1.4
1.2
431.68
209.93
u/ml
0.35
53
328
96
645
1.59
3.89
2.6
3.1
4.02
4.75
e9/l
0.89
87
563
192
1499
1.43
3.74
3.5
3.0
0.00
0.07
—
6
29
73
463
1.66
3.73
1.2
1.2
—
—
—
0
0
38
198
1.99
3.67
1.6
1.6
11.08
7.94
u/ml
—
5
35
35
177
2.04
3.67
2.9
1.8
20.93
20.22
s
0.73
30
164
16
56
2.91
3.65
1.6
1.3
52.84
28.59
ng/l
0.31
16
56
191
1496
1.42
3.64
3.8
3.2
0.02
0.00
estimate
0.40
65
446
263
2179
1.39
3.59
13.2
12.3
1.21
1.19
inr
0.14
216
1762
116
831
1.50
3.51
4.8
2.9
0.82
0.81
mmol/l
0.12
106
788
14
47
3.03
3.43
1.5
1.8
36.00
60.00
%
—
6
32
46
262
1.82
3.43
1.6
2.0
0.00
0.01
estimate
0.49
19
80
107
758
1.51
3.42
1.3
1.2
—
—
—
0
0
9
18
5.06
3.38
1.0
1.3
—
0.20
%
—
0
5
126
926
1.46
3.35
2.9
2.6
504.76
505.97
mosm/kgh2o
0.02
109
807
27
129
2.15
3.29
1.1
1.1
—
—
—
0
0
29
143
2.08
3.27
2.0
4.0
1.21
2.53
ratio
1.74
15
82
127
948
1.44
3.10
1.7
1.9
—
—
—
0
0
13
45
2.93
3.04
2.0
2.6
—
—
—
0
0
30
155
1.99
3.00
2.3
4.2
33.30
74.88
mg/l
0.57
25
136
9
21
4.34
3.00
1.3
1.0
—
—
—
0
0
9
21
4.34
3.00
1.3
1.0
—
—
—
0
0
9
21
4.34
3.00
1.3
1.0
—
—
—
0
0
24
115
2.14
2.93
1.7
1.8
—
—
—
0
0
18
76
2.41
2.92
1.0
1.1
1.74
1.69
eliau/ml
—
9
33
11
32
3.48
2.91
1.6
1.7
37.40
43.10
%
—
5
20
68
452
1.57
2.90
2.3
2.1
0.22
0.22
g/l
0.43
61
424
75
510
1.54
2.89
1.9
2.1
0.00
0.03
estimate
0.50
21
99
556
5391
2.77
2.81
31.1
22.2
258.78
257.83
e9/l
0.12
549
5289
156
1227
1.37
2.80
5.4
4.0
1.02
1.02
kg/l
0.01
103
823
556
5393
2.75
2.77
31.0
22.2
4.45
4.46
e12/l
0.14
549
5271
556
5393
2.75
2.77
31.2
22.3
6.53
6.61
e9/l
0.35
549
5270
73
499
1.53
2.76
1.6
1.5
—
—
—
0
0
208
1716
1.34
2.73
3.4
3.1
—
—
—
0
0
59
386
1.59
2.70
1.4
1.2
—
—
—
0
0
135
1045
1.38
2.66
1.7
1.7
79646453.54
14154655.43
pmol/l
0.38
113
869
14
55
2.58
2.63
3.1
2.3
—
—
—
0
0
7
15
4.71
2.60
1.1
1.4
72.14
58.87
nmol/24h
—
7
15
54
349
1.60
2.60
3.5
3.5
4.34
4.56
pmol/l
1.02
48
311
134
1041
1.38
2.58
2.7
2.7
2.46
2.45
mmol/l
0.32
122
930
196
1619
1.32
2.51
3.0
2.3
—
—
—
0
0
261
2248
1.30
2.45
2.2
1.9
1.36
1.32
mmol/l
0.32
212
1899
11
38
2.93
2.42
1.7
1.2
—
—
—
0
0
274
2382
1.29
2.37
3.1
2.7
—
—
estimate
—
0
0
10
33
3.07
2.36
1.5
3.3
269.10
838.18
mg
—
10
33
80
576
1.45
2.36
2.5
2.3
5.69
6.29
umol/l
0.25
74
500
60
408
1.53
2.34
3.8
3.8
—
—
—
0
0
497
4703
1.47
2.33
7.8
6.1
39.22
38.67
mmol/mol
0.70
472
4408
60
409
1.52
2.31
3.2
3.5
1.24
1.23
mmol/l
0.30
52
354
70
493
1.48
2.31
2.7
2.3
26.95
37.63
u/l
1.84
59
408
509
4843
1.51
2.27
5.8
5.1
5.87
5.85
mmol/l
0.14
477
4444
24
128
1.91
2.25
3.5
3.0
1.67
2.18
index
—
9
68
123
963
1.35
2.24
4.8
3.7
20.08
255.96
ng/l
4.70
90
718
328
2934
1.28
2.20
5.4
4.5
6.72
6.50
mmol/l
1.13
317
2749
106
814
1.37
2.18
1.7
1.7
1118.21
1163.99
nmol/l
0.16
80
598
19
95
2.03
2.13
2.1
2.6
5.41
8.00
pmol/l
1.57
19
95
60
417
1.49
2.13
1.3
1.2
171.14
150.99
u/ml
0.12
21
167
8
25
3.23
2.10
2.3
4.1
15.59
16.88
%
—
8
25
7
20
3.53
2.06
1.3
1.6
93.86
160.58
mmol/24h
—
7
20
23
125
1.88
2.05
1.4
1.5
10961.50
15413.85
e6/l
0.21
14
79
8
26
3.11
2.02
1.3
1.7
—
—
—
0
0
17
84
2.06
1.97
3.7
3.0
—
—
—
0
0
531
5121
1.60
1.96
17.9
12.7
—
—
—
0
0
54
375
1.49
1.94
9.4
5.0
10.23
8.83
mmol/l
0.75
49
359
513
4917
1.46
1.89
5.6
5.0
1.50
1.55
mmol/l
1.60
478
4564
515
4940
1.47
1.89
5.8
5.1
4.61
4.76
mmol/l
3.17
483
4611
521
5009
1.50
1.89
6.6
5.8
2.66
2.77
mmol/l
2.29
487
4659
42
278
1.55
1.88
1.1
1.2
—
—
—
0
0
9
34
2.67
1.87
1.9
1.9
44.10
41.39
%
—
9
34
11
46
2.42
1.86
1.2
2.9
—
—
—
0
0
99
775
1.34
1.81
3.7
2.9
5.12
3.80
e6/l
0.34
39
345
9
35
2.60
1.80
1.4
1.2
19.90
20.17
umol/l
—
9
29
491
4680
1.37
1.78
4.6
4.2
1.31
1.26
mmol/l
1.08
456
4309
60
434
1.43
1.76
5.3
2.9
93.00
73.83
ng/l
0.98
53
385
212
1837
1.25
1.75
3.6
3.5
57.29
64.45
ng/l
0.07
149
1258
18
97
1.88
1.68
1.3
1.4
—
—
—
0
0
7
25
2.82
1.65
1.9
1.8
118.43
50.01
ug/l
—
7
25
15
77
1.97
1.60
1.0
1.1
—
—
—
0
0
61
452
1.39
1.58
1.6
1.3
—
—
—
0
0
5
15
3.35
1.52
1.0
1.1
—
—
—
0
0
39
269
1.48
1.48
1.2
1.3
19.50
27.46
iu/l
1.21
29
229
39
270
1.48
1.46
4.3
3.1
7.43
7.42
ph
0.18
33
224
199
1741
1.22
1.45
3.3
3.0
29.81
29.67
u/l
0.03
188
1648
12
60
2.02
1.39
1.2
1.2
—
—
—
0
0
6
23
2.63
1.37
1.3
1.4
201.67
147.39
nmol/l
—
6
23
5
17
2.96
1.36
1.4
1.3
6.16
7.78
mmol/l
—
5
17
5
17
2.96
1.36
1.2
1.3
—
—
—
0
0
10
47
2.15
1.34
1.5
1.1
—
—
—
0
0
19
113
1.71
1.33
3.1
2.0
119.82
128.35
g/l
1.14
11
85
6
25
2.41
1.24
1.2
1.4
1.92
1.90
umol/l
—
6
20
142
1220
1.22
1.23
2.9
2.2
—
—
—
0
0
10
49
2.06
1.22
5.4
3.4
48.70
57.35
%
—
10
43
21
132
1.61
1.22
1.8
2.8
—
—
—
0
0
15
250
0.59
1.22
3.6
2.4
0.99
1.17
%
0.71
15
250
26
174
1.52
1.17
3.7
3.0
229.92
280.52
mg/l
0.27
12
61
81
658
1.27
1.16
1.3
1.3
—
—
—
0
0
5
20
2.51
1.15
1.2
1.3
—
—
—
0
0
7
30
2.35
1.12
1.6
1.4
92.00
70.63
umol/l
—
7
30
7
31
2.27
1.10
1.1
1.9
9.99
12.32
umol/l
—
7
26
8
41
1.96
1.09
1.5
1.2
1.32
1.14
promille
—
8
31
9
46
1.97
1.04
1.0
1.1
—
—
—
0
0
74
604
1.26
1.03
1.3
1.3
—
—
—
0
0
7
34
2.07
1.03
1.6
1.2
6.70
6.67
ug/l
—
7
29
9
47
1.93
1.02
1.1
1.1
96.11
111.57
pmol/l
—
9
47
7
35
2.01
1.00
1.4
1.2
1.14
1.24
nmol/l
—
7
30
196
1766
1.17
0.98
3.7
3.3
—
0.50
—
0
6
5
23
2.18
0.98
5.8
3.2
826.40
546.00
u/ml
—
5
23
13
77
1.70
0.96
4.5
3.4
0.85
1.72
%
0.77
13
69
26
185
1.42
0.91
1.3
1.3
185.02
230.15
miu/ml
0.45
13
89
11
64
1.73
0.86
2.3
2.7
—
—
—
0
0
50
399
1.28
0.86
11.4
7.0
—
—
—
0
0
24
171
1.42
0.84
1.5
1.4
234.92
296.98
ug/g
0.80
12
100
10
57
1.77
0.84
2.2
2.1
—
—
—
0
0
29
215
1.37
0.82
2.1
2.0
540.37
7300.84
u/l
1.89
12
95
8
48
1.68
0.79
1.6
1.2
—
—
—
0
0
13
82
1.60
0.78
1.0
1.2
—
—
—
0
0
19
134
1.43
0.72
1.4
1.7
—
—
—
0
0
36
284
1.29
0.70
1.8
1.7
—
—
—
0
0
9
59
1.53
0.68
1.3
1.5
287.00
273.26
mosm/kgh2o
—
9
42
5
28
1.79
0.66
1.0
1.2
—
—
—
0
0
62
525
1.20
0.66
10.0
8.0
7.40
7.42
ph
0.62
31
295
19
137
1.40
0.65
2.4
1.9
—
—
—
0
0
61
519
1.20
0.62
10.1
8.0
-0.09
1.01
mmol/l
1.14
55
436
5
30
1.67
0.61
1.0
1.0
—
—
—
0
0
12
80
1.51
0.60
1.8
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
3.2
—
35.12
—
0
12
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
131
1190
1.13
0.58
2.0
1.7
0.77
1.13
mg/l
2.43
101
918
21
158
1.34
0.58
1.1
1.1
—
—
—
0
0
38
459
0.82
0.56
1.5
1.4
—
—
—
0
0
6
37
1.63
0.55
1.0
1.1
—
—
—
0
0
9
60
1.51
0.54
1.1
1.4
30.44
31.83
pg
—
9
60
10
66
1.52
0.53
1.1
1.4
—
—
—
0
0
10
66
1.52
0.53
1.1
1.4
—
—
—
0
0
10
66
1.52
0.53
1.1
1.4
—
—
—
0
0
10
66
1.52
0.53
1.1
1.4
—
—
—
0
0
6
41
1.47
0.50
1.2
1.2
—
—
—
0
0
8
120
0.66
0.46
1.9
1.2
—
—
—
0
0
11
77
1.44
0.46
1.3
1.2
—
—
—
0
0
7
51
1.38
0.44
8.7
3.5
—
—
—
0
0
158
1475
1.10
0.44
1.3
1.5
—
—
—
0
0
8
56
1.43
0.42
1.1
1.1
—
—
—
0
0
5
33
1.52
0.41
1.4
1.4
81.94
82.78
ng/l
—
5
33
0
15
0.00
0.41
0.0
1.0
—
0.21
—
0
7
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
3.31
—
0
11
0
17
0.00
0.40
0.0
1.3
—
2478.20
—
0
10
0
19
0.00
0.39
0.0
1.3
—
599.38
—
0
13
21
170
1.24
0.37
2.1
2.0
2.23
4.22
iu/l
—
10
70
14
180
0.77
0.37
1.1
1.1
0.97
0.89
g/l
0.68
14
180
15
191
0.78
0.37
1.2
1.3
—
—
—
0
0
9
69
1.31
0.37
1.3
1.3
—
—
nmol/l
—
0
0
5
37
1.35
0.37
1.4
1.4
—
—
—
0
0
11
81
1.37
0.36
1.4
1.4
—
0.75
—
0
6
11
81
1.37
0.36
1.3
1.2
157.83
161.33
au/ml
—
6
24
12
90
1.34
0.36
1.2
1.2
—
—
—
0
0
18
144
1.26
0.35
3.7
2.8
24.83
25.26
mmol/l
0.18
18
144
46
405
1.15
0.35
1.7
1.8
3.16
3.44
mmol/l
0.94
30
295
6
45
1.34
0.34
1.8
1.3
—
—
—
0
0
19
156
1.23
0.31
10.6
10.2
—
—
—
0
0
7
52
1.35
0.31
1.1
1.4
265.14
325.19
mu/l
—
7
42
7
99
0.70
0.31
1.0
1.1
—
—
—
0
0
7
99
0.70
0.31
1.0
1.1
—
—
—
0
0
7
53
1.32
0.31
2.0
2.5
—
—
—
0
0
14
111
1.27
0.30
3.6
3.7
—
—
—
0
0
13
102
1.28
0.30
1.5
1.3
—
—
—
0
0
14
174
0.80
0.30
1.1
1.1
1.55
1.58
g/l
0.25
14
174
23
195
1.19
0.28
4.6
3.1
—
—
—
0
0
11
139
0.79
0.27
1.5
1.2
—
—
—
0
0
67
620
1.09
0.24
8.6
6.2
104.82
103.99
mmol/l
0.93
67
620
52
475
1.10
0.24
4.2
2.8
7.37
7.38
ph
0.48
33
265
11
136
0.81
0.23
1.2
1.6
—
—
—
0
0
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
23
262
0.87
0.21
1.1
1.9
—
—
—
0
0
5
42
1.19
0.21
2.0
1.4
—
—
—
0
0
5
42
1.19
0.21
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.4
—
3.00
—
0
5
0
10
0.00
0.21
0.0
3.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
59.17
—
0
12
49
451
1.09
0.21
4.5
2.8
1.56
1.94
mmol/l
0.31
43
381
11
133
0.82
0.19
1.2
1.5
—
—
—
0
0
52
482
1.09
0.19
5.5
3.9
7.39
7.36
ph
0.92
41
337
11
131
0.84
0.17
1.2
1.5
1.30
1.29
mm
—
6
99
10
82
1.22
0.17
1.0
1.1
—
—
—
0
0
6
77
0.78
0.15
1.2
1.1
—
—
—
0
0
201
1959
1.04
0.15
3.5
3.2
—
—
—
0
0
6
80
0.75
0.15
1.0
1.1
—
15.60
—
0
10
20
178
1.13
0.15
1.3
1.5
—
—
—
0
0
40
373
1.08
0.14
2.3
3.5
23.17
79.82
u/ml
1.08
40
362
39
365
1.07
0.12
3.5
2.9
0.92
0.72
ug/l
0.27
28
217
46
434
1.07
0.12
3.2
2.4
5.77
6.10
ph
2.02
33
281
59
562
1.06
0.12
1.5
1.5
—
—
—
0
0
24
220
1.09
0.12
1.1
1.1
—
—
—
0
0
26
281
0.92
0.11
1.3
1.6
1047.04
948.79
mu/l
0.27
19
236
21
192
1.10
0.11
1.2
1.5
—
—
—
0
0
51
534
0.95
0.10
2.8
4.2
62.44
17.20
ug/l
0.34
39
437
5
45
1.11
0.10
1.8
1.2
—
—
—
0
0
22
203
1.09
0.09
1.4
1.4
0.42
0.25
mg/l
—
9
80
17
155
1.10
0.09
1.3
1.4
—
—
—
0
0
21
194
1.09
0.09
1.2
1.4
—
—
—
0
0
6
57
1.05
0.08
1.2
1.1
—
—
—
0
0
37
354
1.05
0.06
2.0
2.2
39.96
7.31
ug/l
0.63
29
308
11
100
1.10
0.05
1.0
1.1
0.31
2.05
u/ml
—
6
54
10
91
1.10
0.04
1.5
1.5
—
—
—
0
0
43
418
1.03
0.04
10.8
6.3
1.19
1.29
mmol/l
0.38
43
413
61
597
1.02
0.04
1.8
1.7
—
—
—
0
0
20
193
1.04
0.01
1.3
1.4
—
—
—
0
0
20
194
1.03
0.00
1.3
1.4
—
—
—
0
0
54
546
0.99
0.00
1.5
1.7
—
—
—
0
0
13
134
0.97
0.00
1.5
1.3
489.00
506.31
mg/l
0.08
13
125
15
152
0.99
0.00
1.3
1.3
—
—
—
0
0
26
258
1.01
0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
10.0
—
9.00
—
0
6
0
6
0.00
0.00
0.0
5.0
—
38.17
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
1.81
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
9
90
1.00
-0.00
2.7
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.4
—
0.16
—
0
5
5
52
0.96
-0.00
1.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
0.04
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
21.04
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_LOCALSCLERODERMA and mortality.

Females

Parameter HR [95% CI] p-value
L12_LOCALSCLERODERMA 1.057 [0.89, 1.26] 0.536
Birth year 0.991 [0.98, 1.0] 0.034

During the follow-up period (1.1.1998 — 31.12.2019), 207 out of 2016 females with L12_LOCALSCLERODERMA died.

Males

Parameter HR [95% CI] p-value
L12_LOCALSCLERODERMA 1.088 [0.8, 1.49] 0.599
Birth year 0.989 [0.98, 1.0] 0.018

During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 560 males with L12_LOCALSCLERODERMA died.

Mortality risk

Mortality risk for people of age

years, who have L12_LOCALSCLERODERMA.

N-year risk Females Males
1 0.082% 0.212%
5 0.556% 1.342%
10 1.324% 3.33%
15 2.594% 6.147%
20 4.421% 10.464%

Relationships between endpoints

↥

Index endpoint: L12_LOCALSCLERODERMA – Localized scleroderma [morphea]

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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