otosclerosis: Formation of spongy bone in the labyrinth capsule which can progress toward the stapes (stapedial fixation) or anteriorly toward the cochlea leading to conductive, sensorineural, or mixed hearing loss. Several genes are associated with familial otosclerosis with varied clinical signs.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3330 |
4. Check minimum number of eventsNone |
3330 |
5. Include endpointsNone |
3330 |
6. Filter based on genotype QC (FinnGen only) |
2976 |
Control definitions (FinnGen only)
- Control exclude
- H8_INNER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H80-H83
- Name in latin
- Otosclerosis
Similar endpoints
↥List of similar endpoints to
Otosclerosis
based on the number of shared cases.
Similar with more cases:
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22316 | 13797 | 8374 |
| Only index persons | 20162 | 12689 | 7473 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.33 | 0.40 | 0.23 |
| Only index persons | 0.40 | 0.47 | 0.29 |
| Median age at first event (years) | |||
| Whole population | 46.35 | 46.34 | 46.36 |
| Only index persons | 45.60 | 45.55 | 45.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2976 | 1898 | 1078 |
| Unadjusted period prevalence (%) | 0.61 | 0.67 | 0.49 |
| Median age at first event (years) | 45.69 | 44.63 | 47.57 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3072
- Matched controls
- 30720
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.4
314.6
1119
3562
UDC00
NOMESCO Finland
Ear microscopy
6.3
309.6
590
1110
H80.1
ICD-10 Finland
Otosclerosis involving oval window, obliterative
+∞
307.7
413
*
DDA00
NOMESCO Finland
Stapedotomy
5683.6
307.7
1144
*
38699, ,
ICD-8 Finland
+∞
307.7
605
*
4133
FHL
Stapedectomy sampling
+∞
307.7
437
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
54.9
307.7
537
118
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
28.7
307.7
224
84
DFF00
NOMESCO Finland
Pure tone audiometry
8.0
307.7
1033
1825
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
33.6
307.7
360
121
3870A
ICD-9 Finland
Otosclerosis involving oval window, nonobliterative
+∞
307.7
537
*
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
14725.5
307.7
1545
*
ZXC10
NOMESCO Finland
Use of laser
33.0
307.7
632
239
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
38.9
307.7
616
197
Z01.1
ICD-10 Finland
Examination of ears and hearing
6.3
307.7
1143
2653
H80.9
ICD-10 Finland
Otosclerosis, unspecified
13767.0
307.7
1492
*
DC1AD
NOMESCO Finland
Temporalbone CT
23.9
295.4
214
96
H80.8
ICD-10 Finland
Other otosclerosis
+∞
287.1
271
*
Z97.4
ICD-10 Finland
Presence of external hearing-aid
6.7
258.5
448
761
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
5.7
256.9
542
1113
DDB00
NOMESCO Finland
Stapedectomy
+∞
247.3
234
*
H80
ICD-10 Finland
Otosclerosis
2170.3
222.5
213
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
7.1
221.9
359
565
DFF15
NOMESCO Finland
Speech audiometry
5.6
194.0
398
789
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
5.3
180.2
401
853
Z3229
NOMESCO Finland
Other healthcare associate professional
4.3
177.3
518
1373
H81.0
ICD-10 Finland
Ménière disease
29.1
171.8
115
41
DFF10
NOMESCO Finland
Measurement of acoustic impedance (tympanometry and reflex testing)
62.3
142.4
79
13
R5120
NOMESCO Finland
Preparation of an aid
6.2
139.5
251
436
DAX08
NOMESCO Finland
Fitting of hearing aid
4.4
138.1
381
959
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
16.5
109.9
93
58
H02
ICPC
Hearing complaint
2.7
102.3
686
2965
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
4.7
96.1
234
530
DCD10
NOMESCO Finland
Tympanoplasty
38.7
92.7
57
15
YPA00
NOMESCO Finland
Excision of blood vessel for transplantation
915.0
91.3
89
*
H80.20
ICD-10 Finland
Otosclerosis involving round window
+∞
87.9
84
*
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
4.9
86.9
201
436
H91.9
ICD-10 Finland
Hearing loss, unspecified
3.7
83.9
292
859
N07CA01
ATC
betahistine; oral
3.4
78.1
306
971
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.5
73.4
545
2440
4139
FHL
Other measure in this category
+∞
66.9
64
*
DFE00
NOMESCO Finland
Insertion of cochlear implant
22.6
66.9
49
22
H90.2
ICD-10 Finland
Conductive hearing loss, unspecified
13.5
64.8
61
46
DDW99
NOMESCO Finland
Other operation on ossicles of ear
313.8
60.6
61
*
H81.3
ICD-10 Finland
Other peripheral vertigo
7.4
59.0
86
119
4134
FHL
Interposition, removal of the disk and placing at least another column on top of the window
+∞
57.5
55
*
H81.2
ICD-10 Finland
Vestibular neuronitis
25.3
56.9
40
16
DFX00
NOMESCO Finland
Connecting cochlear implant
20.8
48.7
37
18
DCA30
NOMESCO Finland
Exploration of middle ear
101.7
45.9
50
5
R5140
NOMESCO Finland
Monitoring the use of the aid
2.2
41.8
410
2035
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
2.5
39.0
254
1055
H80.28
ICD-10 Finland
Cochlear otosclerosis
+∞
38.6
37
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
6.2
37.4
64
105
RK520, ,
NOMESCO Finland
11.3
35.4
37
33
SPAT1043
SPAT
Audiometry
2.1
32.9
356
1827
H93.1
ICD-10 Finland
Tinnitus
2.3
29.4
244
1127
DE2CG
NOMESCO Finland
Acoustic channel extensive MRI examination with high intensity magnet
5.1
28.9
61
122
H74.3
ICD-10 Finland
Other acquired abnormalities of ear ossicles
101.0
27.7
30
*
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
37.0
26.1
33
9
TDA90
NOMESCO Finland
Removal wax from ear
4.3
24.7
64
152
DFF59
NOMESCO Finland
Other assessment of balance
6.2
24.1
41
67
RK320, ,
NOMESCO Finland
5.8
23.7
43
75
DCB10
NOMESCO Finland
Freeing of adhesions of middle ear
65.5
22.8
26
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
3.5
22.7
77
222
DCD00
NOMESCO Finland
Myringoplasty
6.1
22.5
39
65
H29
ICPC
Ear symptom/complaint other
1.8
22.2
391
2342
DFF16
NOMESCO Finland
Speech-in-noise audiometry
19.6
22.1
33
17
Z97.8
ICD-10 Finland
Presence of other specified devices
7.1
22.0
33
47
ZXA05
NOMESCO Finland
Left side
1.5
21.9
748
5295
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
23.3
21.2
30
13
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
34.0
21.1
27
8
RK110, ,
NOMESCO Finland
5.5
21.0
40
73
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
8.7
20.7
26
30
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
2.7
20.3
110
417
DFX03
NOMESCO Finland
Review, maintenance and user education for hearing aid
5.7
20.2
37
65
R4135
NOMESCO Finland
Rehabilitation for hearing problems
3.2
19.6
76
239
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
3.9
19.3
56
145
H74.1
ICD-10 Finland
Adhesive middle ear disease
8.4
19.3
25
30
H80.2
ICD-10 Finland
Cochlear otosclerosis
+∞
18.8
18
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
3.9
18.7
55
144
ZXA00
NOMESCO Finland
Right side
1.5
18.6
788
5806
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
18.5
220
1163
DDD10
NOMESCO Finland
Interposition between malleus and stapes
95.6
17.6
19
*
H28
ICPC
Limited function/disability (H)
3.8
16.9
51
136
DDA10
NOMESCO Finland
Exploration of ossicular chain
+∞
16.7
16
*
WX002
NOMESCO Finland
Sedation and analgesia
1.5
16.7
574
4041
DEA10
NOMESCO Finland
Attico-antrotomy
20.1
16.4
24
12
4161
FHL
Exploratory tympanotomy
47.8
16.0
19
*
H91.8
ICD-10 Finland
Other specified hearing loss
3.6
15.9
51
142
ZXD20
NOMESCO Finland
Day surgery
1.6
15.8
368
2368
Q78.00
ICD-10 Finland
Congenital osteogenesis imperfecta
85.5
15.6
17
*
H83
ICPC
Otosclerosis
+∞
14.6
14
*
DE2BG
NOMESCO Finland
Acoustic channel MRI examination with high intensity magnet
3.8
14.4
43
114
H83.1
ICD-10 Finland
Labyrinthine fistula
+∞
13.5
13
*
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
13.4
2035
18189
R42
ICD-10 Finland
Dizziness and giddiness
1.4
13.3
595
4390
H81
ICPC
Excessive ear wax
1.5
13.3
507
3628
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
4.1
13.3
36
89
3890A
ICD-9 Finland
Deafness, Conductive deafness
40.2
13.1
16
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
12.8
1056
8614
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
12.8
1003
8123
H91.1
ICD-10 Finland
Presbycusis
1.8
12.0
195
1138
RK420, ,
NOMESCO Finland
13.4
11.9
20
15
SPAT1352
SPAT
Inspection, maintenance and instruction for use of hearing aid
3.1
11.7
48
157
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
2.9
11.7
53
184
DDD00
NOMESCO Finland
Mobilisation of stapes
+∞
11.5
11
*
H91
ICD-10 Finland
Other hearing loss
3.4
11.2
40
120
Z45.3
ICD-10 Finland
Adjustment and management of implanted hearing device
28.1
10.7
14
5
H60.3
ICD-10 Finland
Other infective otitis externa
2.4
10.4
72
309
H61.2
ICD-10 Finland
Impacted cerumen
1.7
10.2
196
1198
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.7
10.2
168
985
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.4
10.1
489
3647
1450
FHL
Otomicroscopy
9.1
10.0
20
22
UDC10
NOMESCO Finland
Tympanoscopy
26.1
9.8
13
5
H60.9
ICD-10 Finland
Otitis externa, unspecified
1.6
9.7
199
1238
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
5.0
9.6
20
40
DC1AI
NOMESCO Finland
Cone beam CT of ear
17.6
9.4
14
8
RL210, ,
NOMESCO Finland
4.9
9.3
20
41
H90
ICD-10 Finland
Conductive and sensorineural hearing loss
6.9
9.3
22
32
H13
ICPC
Plugged feeling ear
1.4
9.1
531
4079
RK120, ,
NOMESCO Finland
8.3
9.1
19
23
ZXE00
NOMESCO Finland
One hour or less
1.3
8.4
1021
8657
\1, ,
NOMESCO Finland
+∞
8.3
8
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
2.6
8.2
44
168
R5599
NOMESCO Finland
Other rehabilitation service
2.0
8.2
80
397
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
2.2
8.2
66
304
Z96.2
ICD-10 Finland
Presence of otological and audiological implants
15.0
7.7
12
8
H66.9
ICD-10 Finland
Otitis media, unspecified
1.7
7.7
138
830
SPAT1041
SPAT
Comprehensive hearing test
2.7
7.7
39
145
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
2.0
7.6
75
374
H60.8
ICD-10 Finland
Other otitis externa
1.9
7.5
84
437
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.2
7.5
1149
9972
TDB00
NOMESCO Finland
Removal of foreign body from external auditory canal
+∞
7.3
7
*
4132
FHL
Crurotomy, fork truncation, and partial removal of the tripod plate
+∞
7.3
7
*
RK530, ,
NOMESCO Finland
20.1
7.1
10
5
Q16.3
ICD-10 Finland
Congenital malformation of ear ossicles
40.1
6.8
8
*
H92.0
ICD-10 Finland
Otalgia
1.6
6.6
151
967
S02CA03
ATC
hydrocortisone and antiinfectives; otic
12.3
6.6
11
9
4122
FHL
Tympanostomy (tympanic tube)
3.8
6.5
19
50
J01CA04
ATC
amoxicillin; systemic
1.2
6.4
2278
21422
H81.9
ICD-10 Finland
Disorder of vestibular function, unspecified
3.5
6.4
21
60
DDD20
NOMESCO Finland
Interposition between eardrum and footplate of stapes
70.0
6.4
7
*
H01
ICPC
Ear pain/earache
1.4
6.4
277
2022
SFA20
NOMESCO Finland
Two-surface restoration
1.2
6.4
1544
13966
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.2
6.4
1459
13130
N05AB04
ATC
prochlorperazine; systemic, rectal
2.1
6.4
54
255
38790
ICD-8 Finland
Other disease of ear and mastoid process, Degeneratio nervi acustici
11.0
6.3
11
10
H91.3
ICD-10 Finland
Deaf mutism, not elsewhere classified
26.7
6.2
8
*
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
10.0
6.0
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
446
3453
1.34
7.16
5.1
5.1
33.86
32.81
%
1.13
280
2273
2857
27751
1.42
5.78
13.0
12.9
25.61
25.62
u/l
0.01
2761
26986
2591
24844
1.27
5.52
5.8
5.7
1.94
1.94
mu/l
0.07
2374
22985
2873
27994
1.41
5.10
22.0
22.3
77.11
77.11
umol/l
0.00
2839
27670
2799
27166
1.34
5.05
19.8
20.3
3.97
3.98
mmol/l
0.11
2736
26626
2793
27115
1.33
4.90
19.5
20.1
139.89
139.71
mmol/l
3.61
2732
26620
1660
15384
1.17
4.51
2.8
2.8
—
—
—
0
0
2907
28438
1.41
4.49
25.1
25.9
6.60
6.73
e9/l
2.15
2830
27777
2625
25334
1.25
4.47
6.4
6.6
38.81
39.47
mmol/mol
4.38
2412
23677
2906
28435
1.41
4.40
25.1
25.8
91.32
91.38
fl
0.30
2868
28131
2906
28437
1.41
4.38
25.6
26.3
41.63
40.05
%
0.56
2867
28117
2906
28438
1.40
4.37
25.1
25.8
4.46
4.44
e12/l
0.61
2827
27780
229
1730
1.35
4.35
1.3
1.3
34.98
54.99
au/ml
1.14
14
131
2906
28444
1.40
4.30
25.3
26.0
134.41
133.96
g/l
1.00
2868
28145
2708
26253
1.27
4.27
5.5
5.3
4.68
4.66
mmol/l
0.42
2494
24514
2904
28431
1.39
4.20
25.2
25.9
250.29
252.33
e9/l
0.97
2829
27866
2692
26098
1.25
4.12
5.4
5.2
1.51
1.49
mmol/l
1.21
2458
24207
246
1897
1.32
4.08
2.4
2.4
15.54
22.29
au/ml
1.17
27
177
2157
20490
1.18
4.07
4.7
4.5
12.13
12.83
mm/h
1.46
2002
19168
2743
26663
1.27
4.01
6.3
6.1
2.74
2.71
mmol/l
0.86
2520
24783
1290
11801
1.16
3.95
2.1
1.9
1.32
1.36
mmol/l
1.17
1062
9875
1424
13210
1.15
3.43
6.5
6.8
1.22
1.21
mmol/l
4.73
1289
12226
2634
25572
1.21
3.38
16.3
16.7
78.59
78.67
ml/min/173m2
0.07
2458
23810
2653
25780
1.21
3.34
5.5
5.4
5.87
5.96
mmol/l
3.83
2406
23684
2574
24964
1.19
3.19
4.5
4.4
1.26
1.29
mmol/l
1.76
2333
22903
1408
13104
1.14
3.13
2.5
2.5
79.82
78.92
nmol/l
0.56
1261
11862
1566
14704
1.13
2.97
7.3
7.6
1.22
1.21
mmol/l
5.02
1326
12723
56
348
1.62
2.97
2.1
2.3
28.44
20.84
mg/l
0.50
18
131
1373
12841
1.13
2.68
2.2
2.2
97.83
96.52
pmol/l
0.46
711
6644
694
6240
1.14
2.51
1.3
1.3
1.89
1.71
u/ml
0.10
167
1662
2201
21238
1.13
2.37
4.6
4.6
14.74
14.85
pmol/l
1.36
2006
19518
591
5281
1.15
2.33
1.3
1.3
27.69
32.51
iu/ml
0.55
177
1641
44
279
1.59
2.22
1.3
1.2
—
—
—
0
0
93
1239
0.74
2.14
2.0
2.0
3.38
2.24
ug/l
0.46
80
1111
394
3468
1.16
1.93
2.2
2.3
124.10
136.52
ug/g
0.26
296
2755
902
8368
1.11
1.90
1.7
1.7
19.78
20.48
nmol/l
0.79
731
7056
171
1401
1.23
1.88
2.2
2.3
0.00
0.57
estimate
0.51
51
445
55
383
1.44
1.85
1.5
1.4
—
—
—
0
0
959
8937
1.11
1.84
2.1
2.2
155.07
209.93
u/l
2.84
903
8454
21
115
1.83
1.82
1.1
1.1
64.86
423.36
ng/l
—
7
33
53
368
1.45
1.82
1.6
1.4
—
—
—
0
0
53
369
1.44
1.80
1.6
1.4
—
—
—
0
0
55
386
1.43
1.79
1.5
1.4
—
—
—
0
0
111
871
1.28
1.77
1.3
1.2
13.84
44.36
u/ml
—
10
41
53
370
1.44
1.77
1.6
1.4
—
—
—
0
0
38
569
0.66
1.76
1.4
1.8
0.82
0.84
nmol/l
0.06
30
476
29
177
1.64
1.76
1.6
1.9
—
—
—
0
0
304
3480
0.86
1.75
1.9
1.9
—
—
—
0
0
35
225
1.56
1.73
1.3
1.2
—
—
—
0
0
1346
12783
1.09
1.72
3.0
3.1
139.06
126.95
ug/l
0.65
1244
11927
55
390
1.42
1.70
1.5
1.4
—
—
—
0
0
2215
21526
1.10
1.70
8.6
8.7
80.68
79.98
u/l
0.20
2079
20470
22
126
1.75
1.67
1.2
1.2
—
—
—
0
0
2674
26273
1.14
1.63
16.4
17.0
23.81
24.44
mg/l
0.42
2208
21793
47
655
0.71
1.52
2.7
2.3
146.78
103.08
ug/min
0.24
32
392
455
4119
1.12
1.49
1.5
1.5
—
—
—
0
0
122
1489
0.81
1.48
4.3
3.8
45.88
47.88
%
0.38
117
1464
60
799
0.75
1.46
3.4
4.0
3.93
3.87
mmol/l
0.47
60
793
537
4915
1.11
1.45
1.7
1.7
1029.60
1183.25
nmol/l
4.10
389
3727
35
236
1.49
1.44
1.3
1.2
—
—
—
0
0
35
236
1.49
1.44
1.3
1.2
—
—
—
0
0
19
316
0.60
1.44
1.3
1.5
6.53
6.33
mmol/l
0.23
19
299
214
2473
0.86
1.43
3.3
3.1
4.40
4.52
kpa
0.43
207
2402
102
818
1.26
1.42
1.2
1.3
5.24
6.75
u/ml
—
8
81
592
5453
1.11
1.42
1.5
1.5
2.44
2.47
g/l
0.10
352
3301
1380
13202
1.08
1.40
15.5
15.2
1.26
1.25
inr
0.05
1142
10956
9
40
2.25
1.40
1.1
1.1
—
—
—
0
0
44
313
1.41
1.39
1.2
1.4
31.37
30.88
u/l
0.04
38
263
34
230
1.48
1.39
1.3
1.2
—
—
—
0
0
63
825
0.76
1.38
1.5
1.5
—
—
—
0
0
794
7432
1.09
1.36
3.0
2.8
334.70
340.98
umol/l
1.05
701
6552
361
4003
0.89
1.33
5.9
6.1
1.01
1.04
mmol/l
1.37
343
3714
16
90
1.78
1.33
1.7
1.5
91.58
459.28
nmol/24h
0.61
16
90
796
7460
1.09
1.32
6.0
5.6
2.20
2.96
ug/l
2.29
710
6741
7
150
0.47
1.31
1.0
1.2
1.00
1.06
ratio
—
7
125
30
201
1.50
1.29
1.1
1.2
—
—
—
0
0
202
2323
0.86
1.29
2.6
2.8
67.41
64.81
ml/min/173m2
0.51
88
1006
131
1562
0.83
1.28
3.4
2.8
0.60
0.62
%
0.34
131
1553
101
821
1.24
1.28
1.2
1.3
5.40
8.09
u/ml
0.52
15
122
1372
13158
1.08
1.27
6.4
6.5
57.29
57.40
%
0.13
1290
12561
157
1334
1.19
1.27
1.0
1.0
—
—
—
0
0
1086
10333
1.08
1.24
3.4
3.6
2.37
2.36
mmol/l
1.37
969
9375
536
4950
1.10
1.23
1.3
1.3
8.86
11.89
u/ml
0.56
198
1884
310
3450
0.89
1.23
8.2
7.8
0.95
1.00
mmol/l
0.08
259
2849
35
246
1.43
1.21
1.3
1.1
—
—
—
0
0
23
148
1.56
1.20
1.3
1.2
—
—
—
0
0
212
1858
1.15
1.18
1.2
1.2
118.81
146.61
u/ml
0.59
78
681
8
38
2.11
1.18
1.3
1.1
—
—
—
0
0
134
1580
0.84
1.18
3.4
2.8
1.07
1.19
%
1.60
134
1568
19
117
1.63
1.18
1.4
1.3
—
—
—
0
0
81
650
1.25
1.17
1.2
1.2
45.34
46.01
u/ml
—
10
73
0
34
0.00
1.16
0.0
1.0
—
—
—
0
0
14
80
1.75
1.12
1.1
1.1
—
—
—
0
0
1538
14859
1.07
1.12
4.0
4.1
0.03
0.11
estimate
0.34
269
2988
1394
13430
1.07
1.10
6.5
6.7
27.50
27.55
%
0.06
1309
12713
278
3090
0.89
1.09
8.4
8.2
95.51
95.61
%
0.07
268
2995
61
773
0.78
1.09
1.2
1.1
—
—
—
0
0
5
21
2.38
1.09
1.0
1.2
5.72
6.09
mmol/l
—
5
21
8
41
1.95
1.08
1.1
1.2
27.76
42.71
mg/l
—
8
36
21
136
1.55
1.08
2.1
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
76
935
0.81
1.06
3.4
3.2
0.31
0.35
iu/ml
0.50
42
526
61
769
0.79
1.06
1.2
1.1
—
—
—
0
0
28
196
1.43
1.02
1.5
1.6
4.96
7.11
u/l
0.49
23
163
10
53
1.89
1.01
2.2
4.3
86.20
188.62
ng/l
—
5
23
214
2402
0.88
1.01
3.9
4.2
1.23
1.23
mmol/l
0.36
178
2079
16
249
0.64
0.99
1.8
1.6
—
—
—
0
0
1350
13028
1.06
0.98
4.8
5.2
35.72
35.42
g/l
1.24
1257
12252
5
23
2.18
0.98
1.2
1.2
—
—
—
0
0
159
1815
0.87
0.97
6.2
7.2
24.60
24.52
mmol/l
0.09
151
1739
138
1196
1.16
0.94
1.9
1.8
11.35
6.91
iu/ml
0.63
31
281
145
1660
0.87
0.93
4.1
3.8
105.08
72.65
u/ml
0.40
139
1604
319
3481
0.91
0.92
8.1
7.8
5.07
5.11
kpa
0.38
309
3356
319
3479
0.91
0.91
8.1
7.8
13.02
12.38
kpa
1.02
309
3356
127
1099
1.16
0.89
1.4
1.4
39.21
32.55
iu/l
1.22
116
946
43
332
1.30
0.89
1.2
1.2
57.21
59.01
u/l
0.10
38
299
6
29
2.07
0.89
1.2
1.0
8.12
6.86
u/ml
—
6
29
817
7780
1.07
0.89
3.1
3.1
0.08
0.04
0.21
12
202
460
4926
0.92
0.88
2.1
1.9
—
—
—
0
0
90
758
1.19
0.88
1.8
2.1
11.32
12.13
mg/l
0.58
83
702
7
130
0.54
0.87
12.9
13.6
137844.14
874.46
nmol/l
—
7
125
66
802
0.82
0.86
1.8
2.0
2.50
11.53
iu/l
0.66
26
317
1500
14572
1.06
0.84
4.0
4.1
0.00
0.00
estimate
0.50
279
3100
83
700
1.19
0.81
1.1
1.1
3.62
4.50
0.33
13
81
91
774
1.18
0.81
1.5
1.4
—
—
—
0
0
1014
10537
0.94
0.81
4.3
4.1
101.23
103.67
e6/l
0.02
686
7445
8
47
1.70
0.80
1.8
2.4
12.88
16.94
umol/l
—
8
47
343
3699
0.92
0.79
1.9
1.8
—
—
—
0
0
6
33
1.82
0.79
1.3
1.0
—
—
—
0
0
10
163
0.61
0.78
1.2
1.3
—
—
—
0
0
261
2389
1.10
0.77
3.7
4.0
95.48
91.05
ng/l
0.25
223
2052
23
314
0.73
0.76
2.8
5.4
6.69
7.24
mmol/l
0.49
17
268
50
406
1.24
0.73
1.2
1.2
2.58
4.20
u/ml
1.10
24
174
106
923
1.15
0.73
1.6
1.8
2.42
4.79
mg/l
2.42
78
693
6
107
0.56
0.72
1.0
1.1
101.17
92.16
%
—
6
86
31
401
0.77
0.72
1.4
1.6
—
—
—
0
0
2218
21832
1.06
0.71
20.5
20.9
13.59
13.70
%
4.38
2190
21527
181
2001
0.90
0.71
9.9
9.3
1.23
1.29
%
0.48
181
1990
27
203
1.33
0.70
2.4
1.7
5.35
5.63
umol/l
0.07
19
144
267
2892
0.92
0.70
8.8
8.7
119.95
120.65
g/l
0.24
260
2827
614
6447
0.94
0.69
2.9
2.8
5.00
5.78
e6/l
1.25
550
5870
17
118
1.44
0.69
2.6
1.9
—
—
—
0
0
17
118
1.44
0.69
2.6
1.9
—
—
—
0
0
17
118
1.44
0.69
2.6
1.9
—
—
—
0
0
5
27
1.85
0.68
1.0
1.0
—
—
—
0
0
5
27
1.85
0.68
5.4
4.5
—
—
—
0
0
1819
17824
1.05
0.68
3.4
3.4
49.67
50.65
u/l
0.16
1705
16670
86
742
1.16
0.68
1.7
1.7
9205.13
12541.70
e6/l
0.63
62
508
1511
14745
1.05
0.67
4.0
4.1
5.34
3.82
estimate
0.11
288
3192
18
128
1.41
0.65
2.8
1.7
38.64
40.27
g/l
0.55
18
128
65
550
1.19
0.65
1.7
1.9
4.81
4.91
mmol/24h
0.10
53
474
7
44
1.59
0.65
1.3
1.2
—
—
—
0
0
223
2425
0.91
0.65
2.4
2.3
8.21
7.38
ug/l
0.19
189
2163
275
2963
0.92
0.65
4.0
3.8
5.83
5.83
kpa
0.04
268
2885
1034
10004
1.05
0.65
3.4
3.4
7.29
7.19
mmol/l
0.31
858
8423
21
154
1.37
0.65
1.1
1.1
—
—
—
0
0
107
1211
0.88
0.64
1.5
1.4
—
—
—
0
0
18
247
0.73
0.64
1.3
1.7
—
—
—
0
0
5
29
1.73
0.64
1.4
1.1
—
—
—
0
0
16
112
1.43
0.63
1.3
1.1
132.02
194.18
iu/ml
0.80
16
112
17
235
0.72
0.63
1.6
1.7
—
—
—
0
0
47
566
0.83
0.61
5.3
3.5
27.02
27.54
mg/l
0.04
30
388
87
759
1.15
0.61
1.4
1.3
—
—
—
0
0
111
986
1.13
0.60
3.5
4.0
24.92
24.94
mmol/l
0.03
103
912
1282
13156
0.96
0.60
2.7
2.8
—
—
estimate
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
240
2223
1.09
0.59
3.3
3.1
10.40
10.60
g/l
0.32
217
2064
271
2524
1.08
0.59
1.9
2.0
3.33
3.43
ratio
0.63
223
1983
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
6
35
1.72
0.57
1.2
1.1
—
—
—
0
0
103
915
1.13
0.57
1.7
1.7
—
—
—
0
0
18
132
1.37
0.57
1.4
1.4
—
—
—
0
0
18
132
1.37
0.57
1.4
1.4
—
—
—
0
0
56
657
0.85
0.56
3.3
2.6
60.06
61.45
%
0.19
56
652
8
55
1.46
0.56
3.5
8.3
5.43
5.51
kpa
—
8
55
24
185
1.30
0.56
1.3
1.3
—
—
—
0
0
214
2311
0.92
0.55
3.2
3.0
157.14
200.23
ng/l
1.13
190
2125
177
1927
0.91
0.55
10.1
9.5
0.63
0.64
%
0.13
177
1915
76
664
1.15
0.54
1.3
1.3
231.42
231.39
miu/ml
0.00
28
288
32
394
0.81
0.54
4.1
2.3
154.61
789.60
u/ml
0.46
32
389
13
182
0.71
0.54
3.4
2.1
6.81
8.73
mmol/l
2.09
13
182
901
9296
0.96
0.53
3.6
3.4
33.78
72.30
e6/l
1.86
659
7091
14
193
0.72
0.53
2.1
1.7
—
—
—
0
0
67
770
0.87
0.53
1.4
1.3
—
—
—
0
0
24
187
1.29
0.52
1.3
1.3
—
—
—
0
0
63
726
0.87
0.52
1.3
1.6
—
—
—
0
0
6
40
1.50
0.51
1.3
1.5
—
—
—
0
0
9
64
1.41
0.51
1.2
1.1
—
—
—
0
0
9
64
1.41
0.51
1.0
1.1
—
—
—
0
0
205
1903
1.08
0.50
3.8
3.8
5.15
5.17
kpa
0.21
195
1833
11
156
0.70
0.49
1.3
1.3
120.67
132.89
nmol/l
0.67
11
156
72
633
1.14
0.49
1.5
1.4
21.40
39.28
e6/l
0.51
55
454
198
1839
1.08
0.48
1.7
1.8
3.44
3.50
mmol/l
0.29
142
1296
16
212
0.75
0.48
1.4
1.4
10.75
13.39
u/l
1.79
16
205
135
1474
0.91
0.47
1.5
1.5
—
—
—
0
0
121
1328
0.91
0.47
3.4
3.3
25.09
25.39
mmol/l
0.46
114
1282
470
4498
1.05
0.47
3.4
3.3
0.78
0.76
ug/l
0.19
303
3010
624
6015
1.05
0.47
5.1
4.6
22.78
21.63
%
1.15
312
3030
114
1035
1.11
0.46
1.6
1.6
20.13
17.35
u/ml
0.13
26
218
798
8228
0.96
0.46
4.2
4.3
0.00
0.00
estimate
0.03
262
2883
139
1275
1.09
0.46
2.0
2.5
3.54
3.72
g/l
0.96
124
1171
16
210
0.76
0.46
1.1
1.5
—
—
—
0
0
27
331
0.81
0.45
1.4
1.4
64904.92
83833.94
e6/l
0.16
13
187
139
1276
1.09
0.45
2.0
2.6
7.41
7.38
g/l
0.06
124
1171
139
1276
1.09
0.45
2.0
2.6
4.28
4.23
g/l
0.15
124
1172
41
347
1.18
0.45
1.7
1.3
277.94
275.92
mosm/kgh2o
0.22
33
268
18
138
1.31
0.45
1.3
1.1
0.53
0.53
ratio
—
7
85
232
2176
1.07
0.45
1.5
1.5
—
—
—
0
0
257
2728
0.94
0.45
2.6
2.3
357.93
377.88
nmol/l
0.96
242
2527
40
338
1.19
0.45
1.4
1.5
50.11
58.34
%
0.53
27
210
1005
9795
1.04
0.45
4.0
4.2
6.85
8.84
mg/mmol
0.59
595
5993
192
1789
1.08
0.45
3.2
3.6
4.45
4.45
pmol/l
0.01
168
1597
10
141
0.71
0.44
1.4
1.2
—
—
—
0
0
994
10195
0.96
0.44
3.5
3.4
—
1.33
—
0
5
121
1106
1.10
0.44
1.9
2.6
0.59
1.03
g/l
0.66
102
955
794
7708
1.04
0.43
3.3
3.6
0.02
0.26
estimate
1.00
221
2422
480
4608
1.05
0.43
3.1
3.1
3.38
2.88
e6/l
0.27
226
2252
51
586
0.87
0.43
1.3
1.5
—
—
—
0
0
131
1204
1.09
0.43
2.0
2.6
2.85
2.90
g/l
0.20
116
1100
102
927
1.10
0.42
1.3
1.4
282.48
270.46
ug/g
0.23
61
538
337
3210
1.06
0.41
4.1
4.3
19.66
22.30
ug/l
0.10
291
2618
48
416
1.16
0.41
1.2
1.2
1.43
3.43
u/ml
1.52
21
144
14
105
1.33
0.41
1.0
1.0
—
—
—
0
0
72
643
1.12
0.41
1.6
1.4
359.50
874.01
e6/l
0.90
56
494
1683
16577
1.03
0.41
4.9
5.1
6.71
6.71
mmol/l
0.05
1593
15766
60
530
1.13
0.40
1.3
1.3
—
—
—
0
0
23
186
1.24
0.40
2.1
2.0
14.00
15.75
%
0.68
23
178
8
60
1.33
0.40
3.5
8.1
6.00
5.96
kpa
—
8
55
0
18
0.00
0.40
0.0
13.0
—
—
—
0
0
1500
14752
1.03
0.39
6.5
6.6
0.19
0.19
e9/l
0.40
1293
12815
7
103
0.68
0.39
1.0
1.1
—
—
—
0
0
1480
14562
1.03
0.37
6.3
6.5
1.87
1.91
e9/l
0.51
1289
12757
52
458
1.14
0.37
1.1
1.1
0.42
1.69
u/ml
2.90
27
241
11
147
0.75
0.37
1.2
2.2
96.36
99.41
%
0.12
11
138
192
1806
1.07
0.37
2.4
2.4
13.46
13.02
nmol/l
0.27
170
1624
576
5577
1.04
0.37
3.6
3.8
255.12
418.20
ng/l
1.35
449
4432
1583
16064
0.97
0.37
9.7
10.0
4.06
4.09
e9/l
0.21
1351
13925
10
72
1.39
0.37
1.4
1.4
—
—
—
0
0
17
134
1.27
0.37
1.0
1.0
—
—
—
0
0
24
289
0.83
0.36
1.2
1.4
297.58
345.70
u/l
0.29
24
280
190
1788
1.07
0.36
1.9
2.0
1.06
1.39
g/l
3.68
173
1647
49
431
1.14
0.36
1.5
1.6
—
—
—
0
0
58
650
0.89
0.36
1.4
1.5
—
—
—
0
0
59
526
1.12
0.36
1.7
1.9
434.28
4325.87
u/l
2.97
24
208
6
42
1.43
0.35
4.3
8.1
10.68
10.42
%
—
6
42
19
153
1.24
0.35
1.2
1.5
6.84
8.33
ug/l
0.47
19
133
44
385
1.14
0.35
1.0
1.0
0.97
3.26
u/ml
2.69
21
186
274
2874
0.95
0.35
3.9
3.8
1.94
1.85
mmol/l
0.15
233
2527
14
108
1.30
0.35
1.0
1.1
—
—
—
0
0
51
575
0.89
0.35
1.4
1.3
—
—
—
0
0
51
575
0.89
0.35
1.4
1.3
—
—
—
0
0
17
135
1.26
0.35
1.4
1.5
167.64
160.90
pmol/l
0.07
17
135
9
124
0.73
0.35
1.7
1.2
5.33
10.53
mm/h
—
9
124
452
4361
1.04
0.35
1.8
2.1
29.66
29.66
s
0.01
442
4251
52
585
0.89
0.35
7.8
8.5
106.30
105.07
mmol/l
1.05
46
522
41
358
1.15
0.34
1.0
1.1
0.52
1.07
u/ml
0.85
19
174
446
4307
1.04
0.33
1.5
1.5
—
—
—
0
0
19
155
1.23
0.32
2.7
1.7
—
—
—
0
0
19
155
1.23
0.32
2.7
1.7
—
—
—
0
0
19
155
1.23
0.32
2.7
1.7
—
—
—
0
0
19
155
1.23
0.32
2.7
1.7
—
—
—
0
0
1538
15172
1.03
0.31
6.8
6.9
11.70
11.35
umol/l
0.35
1459
14514
518
5025
1.04
0.31
3.4
3.5
0.82
0.82
mmol/l
0.45
490
4740
54
601
0.90
0.31
6.7
5.7
422.22
561.94
iu/ml
—
9
89
76
829
0.91
0.30
1.3
1.2
1.53
1.57
g/l
0.52
76
829
34
296
1.15
0.30
1.0
1.1
0.59
3.42
u/ml
2.38
16
123
15
185
0.81
0.29
1.1
1.6
—
—
—
0
0
630
6461
0.97
0.29
4.1
4.3
1.02
1.25
kg/l
0.50
416
4345
58
525
1.11
0.29
1.3
1.2
—
58.82
—
0
5
32
366
0.87
0.29
1.1
1.1
2.12
3.52
—
7
61
88
814
1.08
0.29
1.6
1.8
—
30.85
—
0
5
225
2352
0.95
0.27
2.4
2.5
0.34
0.51
e6/l
1.37
213
2242
95
1020
0.93
0.27
2.1
1.9
—
—
—
0
0
177
1861
0.95
0.27
3.4
3.1
129.52
128.04
g/l
0.37
168
1808
96
894
1.08
0.27
1.4
1.3
—
—
—
0
0
1830
18119
1.02
0.27
5.0
5.0
3068.40
1877.30
e6/l
—
10
255
31
353
0.88
0.27
1.1
1.1
—
—
—
0
0
8
67
1.19
0.26
1.7
1.5
—
—
—
0
0
11
86
1.28
0.26
1.0
1.1
—
—
—
0
0
5
71
0.70
0.26
1.2
1.1
—
—
—
0
0
30
341
0.88
0.25
1.4
1.5
0.27
0.34
nmol/l
0.51
23
245
16
192
0.83
0.25
2.3
2.0
—
—
—
0
0
33
372
0.89
0.25
1.8
1.9
30.46
24.92
ug/l
0.19
33
365
50
549
0.91
0.24
1.5
1.6
877.72
1011.11
mu/l
0.97
42
445
27
308
0.88
0.24
1.5
1.5
1.38
1.12
ratio
0.65
19
194
27
308
0.88
0.24
1.5
1.5
1.10
1.21
ratio
0.29
19
194
27
308
0.88
0.24
1.5
1.5
0.96
0.99
ratio
0.17
19
194
34
302
1.13
0.24
2.4
1.8
—
—
—
0
0
740
7545
0.97
0.24
2.4
2.4
2.84
2.87
mg/l
0.11
623
6517
175
1832
0.95
0.24
1.9
1.7
—
—
—
0
0
15
124
1.21
0.24
1.9
1.4
—
1431149.88
iu/ml
—
0
8
27
307
0.88
0.23
1.5
1.5
—
—
—
0
0
25
218
1.15
0.23
1.0
1.3
—
—
—
0
0
13
106
1.23
0.23
1.8
2.3
18.41
18.05
ug/l
0.03
13
95
35
313
1.12
0.23
1.1
1.1
0.53
1.98
u/ml
3.01
17
147
7
93
0.75
0.22
2.0
1.8
1.67
1.47
ratio
—
7
88
73
783
0.93
0.22
1.8
1.6
—
—
—
0
0
5
41
1.22
0.22
1.2
1.1
—
—
—
0
0
935
9493
0.98
0.22
3.5
3.3
31.36
36.05
u/l
1.53
882
8957
0
10
0.00
0.21
0.0
1.0
—
0.00
—
0
10
90
956
0.94
0.21
1.4
1.4
—
—
—
0
0
40
440
0.91
0.21
1.1
1.1
2.50
1440.85
iu/ml
—
6
91
89
837
1.07
0.21
1.7
1.7
0.22
0.24
g/l
0.64
82
798
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
8
102
0.78
0.21
1.1
1.3
3.88
4.08
umol/l
—
8
86
348
3385
1.03
0.21
2.6
2.7
7.03
7.73
umol/l
0.29
303
2983
0
13
0.00
0.21
0.0
1.2
—
2.85
—
0
13
20
173
1.16
0.21
2.8
2.2
19.79
18.02
nmol/l
0.47
20
161
20
173
1.16
0.21
1.1
1.0
—
—
—
0
0
26
293
0.89
0.20
4.1
4.0
—
—
—
0
0
10
80
1.25
0.20
2.1
2.4
0.80
1.18
ug/l
—
10
75
792
8049
0.98
0.20
3.5
3.3
0.30
0.45
e6/l
1.15
560
5914
0
14
0.00
0.20
0.0
1.1
—
7.75
—
0
14
16
187
0.85
0.20
1.1
1.6
—
—
—
0
0
16
136
1.18
0.20
2.6
4.3
—
—
—
0
0
9
111
0.81
0.20
1.1
2.4
—
26545.74
—
0
19
52
562
0.92
0.19
1.5
1.4
12.55
11.86
u/l
0.13
39
452
48
442
1.09
0.19
1.7
1.3
0.76
4.64
nmol/l
0.48
43
425
16
186
0.86
0.19
1.4
1.5
80.44
83.92
umol/l
0.30
16
186
27
241
1.12
0.19
1.6
1.5
—
—
—
0
0
189
1822
1.04
0.19
2.0
1.9
—
—
—
0
0
49
453
1.08
0.18
1.2
1.1
3.43
22.97
au/ml
—
10
100
32
290
1.10
0.18
2.0
1.5
—
—
—
0
0
107
1021
1.05
0.17
2.0
1.8
—
—
—
0
0
10
82
1.22
0.17
1.9
1.5
9.62
9.52
ug/l
—
10
82
696
7064
0.98
0.16
2.4
2.4
—
—
—
0
0
298
2906
1.03
0.16
1.6
1.8
1.39
1.49
%
1.65
261
2532
44
474
0.93
0.16
1.2
1.5
—
—
—
0
0
27
298
0.91
0.16
3.6
3.6
12.00
12.35
index
0.10
16
168
166
1605
1.04
0.15
3.6
3.7
1.55
1.95
mmol/l
0.87
128
1217
6
77
0.78
0.15
1.0
1.1
—
—
—
0
0
6
78
0.77
0.15
2.2
1.6
—
—
—
0
0
6
79
0.76
0.15
1.2
1.1
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
6
79
0.76
0.15
1.2
1.2
114.33
105.21
%
—
6
71
6
79
0.76
0.15
1.3
1.0
—
—
—
0
0
35
322
1.09
0.15
2.3
1.7
—
—
—
0
0
142
1472
0.96
0.15
3.5
3.4
1.02
1.02
ratio
0.17
131
1319
9
82
1.10
0.15
1.0
1.6
—
—
—
0
0
9
82
1.10
0.15
2.9
3.0
5.12
4.99
kpa
—
9
82
9
82
1.10
0.15
2.9
3.0
10.67
10.18
kpa
—
9
82
21
188
1.12
0.14
1.1
1.1
34.53
45.09
mg/l
0.81
15
161
59
625
0.94
0.14
3.8
3.4
0.84
0.80
nmol/l
0.33
47
501
288
2947
0.97
0.14
2.3
2.2
0.21
0.21
g/l
0.14
274
2769
20
223
0.90
0.14
1.5
1.3
2.12
2.22
mmol/l
0.14
15
207
27
246
1.10
0.14
1.2
1.1
—
—
—
0
0
25
227
1.10
0.14
3.1
2.8
55.80
31.03
mg/l
0.89
15
164
289
2826
1.02
0.14
2.2
2.4
35.34
56.44
u/l
0.64
250
2385
92
960
0.96
0.14
3.8
3.6
2.72
3.12
ratio
0.10
54
560
22
243
0.90
0.13
1.1
1.2
88.14
108.31
pmol/l
1.51
22
243
35
377
0.93
0.13
1.3
1.5
1311.32
4372.39
e6/l
0.72
28
266
619
6107
1.02
0.13
1.6
1.8
42633035.19
35773756.36
pmol/l
0.10
509
5082
103
1071
0.96
0.13
4.6
3.9
50.52
69.46
mg/l
0.51
91
913
917
9077
1.01
0.13
2.6
2.7
58.10
69.99
u/l
0.73
849
8420
114
1099
1.04
0.13
1.8
2.6
9.93
10.33
g/l
0.60
97
985
103
1070
0.96
0.13
2.1
2.2
215.83
671.14
ug/l
1.63
92
1015
215
2202
0.97
0.12
1.7
1.7
—
—
—
0
0
506
4989
1.02
0.12
2.6
2.7
13.16
12.85
umol/l
0.43
480
4656
52
493
1.06
0.11
4.0
3.8
2.37
1.52
%
0.54
46
438
74
772
0.96
0.11
1.2
1.1
0.64
0.63
ratio
0.05
16
119
35
374
0.94
0.11
1.6
1.5
—
—
—
0
0
291
2965
0.98
0.11
3.3
3.6
—
—
—
0
0
125
1212
1.03
0.11
5.2
5.8
0.84
0.88
%
0.56
117
1143
126
1222
1.03
0.11
1.7
1.9
41.99
39.48
u/l
0.69
114
1087
87
903
0.96
0.11
1.3
2.5
0.00
0.00
g/l
-0.00
77
796
100
1033
0.97
0.10
2.2
2.7
—
—
—
0
0
11
96
1.15
0.10
1.0
1.7
16.30
16.23
pmol/l
0.01
11
82
104
1073
0.97
0.10
1.7
1.7
0.23
0.33
mg/l
1.28
41
485
36
382
0.94
0.10
1.4
1.7
—
—
—
0
0
51
486
1.05
0.10
1.2
1.2
272.74
275.48
u/ml
0.03
33
290
90
870
1.04
0.10
1.6
1.5
0.04
8.83
iu/ml
0.58
15
154
129
1325
0.97
0.10
5.1
5.6
1.37
1.57
%
3.21
121
1253
104
1072
0.97
0.09
4.5
3.8
38.06
105.12
mg/l
0.73
92
915
29
271
1.07
0.09
6.4
5.4
371.30
52.97
u/ml
—
9
88
134
1374
0.97
0.09
1.6
1.8
1.64
1.56
g/l
0.39
115
1187
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
16
145
1.10
0.09
1.1
1.1
—
—
—
0
0
42
399
1.05
0.09
1.6
1.3
0.19
0.23
nmol/l
0.35
33
313
264
2684
0.98
0.09
6.9
7.8
8.99
10.18
mmol/l
2.02
255
2583
89
862
1.03
0.09
1.7
1.6
1.16
1.18
g/l
0.46
83
825
78
807
0.97
0.09
1.8
1.6
—
—
—
0
0
65
675
0.96
0.09
2.0
1.7
300.85
305.52
mu/l
0.05
59
619
80
827
0.97
0.09
2.3
1.8
—
—
—
0
0
35
331
1.06
0.08
1.2
1.1
1.37
3.46
eliau/ml
1.91
13
140
12
134
0.90
0.08
2.3
2.4
—
—
—
0
0
24
257
0.93
0.08
1.5
1.4
30.66
31.84
%
0.04
16
152
168
1646
1.02
0.08
1.9
1.8
—
—
—
0
0
81
836
0.97
0.08
2.0
1.8
—
—
—
0
0
95
923
1.03
0.08
1.3
1.3
—
—
—
0
0
28
263
1.07
0.08
2.5
1.8
3.21
4.26
mg/l
1.60
28
257
53
552
0.96
0.08
1.9
1.7
—
—
—
0
0
5
61
0.82
0.08
1.0
1.5
—
—
—
0
0
460
4649
0.99
0.08
2.7
2.7
2.31
2.31
g/l
0.05
429
4303
14
154
0.91
0.08
1.1
1.6
—
—
—
0
0
14
154
0.91
0.08
1.1
1.6
—
—
—
0
0
1085
10787
1.01
0.08
4.0
3.9
40.14
104.28
ng/l
0.89
777
7784
65
673
0.97
0.08
1.3
1.5
—
—
—
0
0
62
642
0.97
0.07
1.7
1.7
—
—
—
0
0
6
72
0.83
0.07
1.0
1.2
—
—
—
0
0
51
530
0.96
0.07
1.2
1.3
36.53
35.49
u/l
0.03
38
454
261
2574
1.02
0.07
2.2
3.0
66.12
66.44
g/l
0.31
237
2374
82
797
1.03
0.07
3.1
3.6
1.31
2.22
index
1.28
42
405
166
1690
0.98
0.07
9.7
10.6
16.15
15.90
%
0.60
160
1632
260
2635
0.99
0.07
2.4
2.7
71.04
70.04
e9/l
0.14
182
1950
56
541
1.04
0.07
1.4
1.4
—
15.81
—
0
9
38
397
0.96
0.07
1.2
1.4
—
—
—
0
0
24
226
1.06
0.06
1.2
1.2
68.00
122.14
titre
—
5
42
20
187
1.07
0.06
1.5
1.2
—
—
—
0
0
96
938
1.02
0.06
1.4
2.5
0.01
0.03
g/l
0.68
86
846
884
8886
0.99
0.06
3.1
3.2
1426.95
1358.08
ng/l
0.11
748
7706
21
223
0.94
0.06
1.0
1.0
523.36
310.09
ng/l
1.35
14
149
727
7313
0.99
0.06
4.2
4.1
89.62
89.94
%
0.13
717
7142
39
375
1.04
0.05
1.0
1.1
0.25
1.23
u/ml
1.69
13
150
49
474
1.03
0.05
1.4
1.4
164.42
156.30
au/ml
0.15
12
140
23
243
0.95
0.05
1.0
1.0
—
—
—
0
0
51
526
0.97
0.05
1.1
1.2
—
273.33
—
0
12
29
277
1.05
0.05
1.3
1.4
346430.43
90737.40
e6/l
0.55
21
187
16
149
1.07
0.05
2.2
2.7
746.13
1084.75
u/ml
0.56
16
149
14
151
0.93
0.05
1.4
1.2
—
—
—
0
0
69
673
1.03
0.05
1.1
1.1
12.30
7.19
eliau/ml
—
7
76
56
576
0.97
0.05
1.3
1.5
—
—
—
0
0
42
406
1.03
0.05
1.2
1.1
—
—
—
0
0
24
252
0.95
0.05
1.1
1.1
—
—
—
0
0
598
6014
0.99
0.04
3.1
3.0
2.46
2.46
mmol/l
0.80
538
5412
20
189
1.06
0.04
1.5
1.2
—
—
—
0
0
14
130
1.08
0.04
1.0
1.3
155.43
158.67
mmol/24h
0.06
14
130
10
91
1.10
0.04
1.2
1.1
—
—
—
0
0
612
6150
0.99
0.04
1.7
1.8
1.65
1.29
mg/l
0.53
470
4814
333
3306
1.01
0.04
6.8
7.0
—
—
—
0
0
10
109
0.92
0.04
1.2
1.4
—
—
—
0
0
26
271
0.96
0.04
1.3
1.3
—
—
—
0
0
31
299
1.04
0.03
1.1
1.3
7.44
7.46
mmol/l
0.01
26
260
14
131
1.07
0.03
2.2
3.5
1.79
1.25
%
0.31
14
131
182
1802
1.01
0.03
1.3
1.3
154.87
201.66
u/ml
0.85
167
1665
39
379
1.03
0.03
1.2
1.1
—
—
—
0
0
26
270
0.96
0.03
2.8
3.0
—
—
—
0
0
79
777
1.02
0.03
1.2
1.2
—
—
—
0
0
28
290
0.97
0.03
1.2
1.2
—
—
—
0
0
11
118
0.93
0.02
1.2
1.1
—
10.64
u/ml
—
0
14
18
188
0.96
0.02
1.2
1.8
87.33
110.25
ng/l
1.15
18
188
12
113
1.06
0.01
1.8
2.7
169.20
141.71
umol/l
—
5
68
1095
10967
1.00
0.01
3.9
4.1
0.03
0.29
estimate
0.70
224
2512
26
267
0.97
0.01
2.3
1.6
—
—
—
0
0
26
267
0.97
0.01
2.3
1.6
—
—
—
0
0
26
267
0.97
0.01
2.3
1.6
—
—
—
0
0
431
4299
1.00
0.01
2.7
2.8
22.24
22.38
%
0.07
404
4002
2171
21698
1.00
0.01
21.1
21.9
332.07
331.56
g/l
1.85
2158
21578
112
1128
0.99
0.01
4.2
3.5
94.77
3887.79
u/ml
0.92
99
966
505
5040
1.00
0.01
3.1
3.0
1.95
1.13
e6/l
0.50
262
2695
18
174
1.03
0.00
1.0
1.4
23.85
22.21
umol/l
0.08
18
158
72
714
1.01
0.00
1.9
2.3
130.88
128.24
g/l
0.35
49
563
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
12
121
0.99
0.00
1.4
2.3
112.33
166.58
%
2.15
12
114
12
121
0.99
0.00
9.4
12.9
0.50
0.63
mmol/l
0.96
12
113
22
225
0.98
0.00
1.0
1.0
58.23
42.31
ng/l
0.79
15
147
19
191
0.99
0.00
1.3
1.5
51.65
55.94
ug/l
0.24
19
191
27
271
1.00
0.00
1.4
1.6
—
—
—
0
0
27
271
1.00
0.00
1.0
1.0
0.07
0.16
u/ml
—
7
91
11
106
1.04
0.00
1.1
1.3
—
—
—
0
0
11
114
0.96
0.00
1.9
2.4
0.63
0.61
mmol/l
0.69
11
114
13
132
0.98
0.00
1.1
1.1
1230.31
1555.47
miu/ml
0.68
13
132
21
208
1.01
0.00
1.2
1.3
0.48
0.94
u/ml
0.39
13
113
1241
12411
1.00
0.00
12.0
12.0
0.00
0.00
e9/l
0.02
1012
10109
111
1114
1.00
0.00
2.3
2.0
—
—
—
0
0
84
843
1.00
0.00
1.3
2.6
0.00
0.00
g/l
-0.00
77
795
22
223
0.99
0.00
1.0
1.0
429.14
747.17
ng/l
5.33
14
147
8
88
0.91
0.00
1.6
2.5
121.50
180.78
%
—
8
81
6
62
0.97
0.00
2.5
2.5
16.00
5.37
ug/l
—
6
62
8
88
0.91
0.00
1.1
1.1
—
—
—
0
0
6
62
0.97
0.00
1.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
2.13
—
0
8
8
84
0.95
-0.00
1.3
1.1
—
—
—
0
0
6
67
0.90
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
269.86
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
345
3450
1.00
-0.00
4.7
4.5
239.84
248.03
u/l
0.70
325
3279
5
49
1.02
-0.00
1.2
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1.17
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
0.01
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
79
0.89
-0.00
1.3
1.1
—
—
—
0
0
46
460
1.00
-0.00
1.7
1.3
0.47
0.39
nmol/l
—
7
24
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_OTOSCLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTOSCLE | 0.764 [0.69, 0.85] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 728 out of 7721 females with H8_OTOSCLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTOSCLE | 0.687 [0.62, 0.76] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.07 |
During the follow-up period (1.1.1998 — 31.12.2019), 547 out of 4710 males with H8_OTOSCLE died.
Mortality risk
Mortality risk for people of age
years, who have H8_OTOSCLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.179% |
| 5 | 0.418% | 0.94% |
| 10 | 1.008% | 2.26% |
| 15 | 1.966% | 4.465% |
| 20 | 3.456% | 7.889% |
Relationships between endpoints
↥Index endpoint: H8_OTOSCLE – Otosclerosis
GWS hits: 41
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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