cocaine dependence: A psychologically and socially impaired state, with or without physiological changes, that develops as a result of using cocaine and which leads to compulsive behaviors to acquire the substance.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
68 |
4. Check minimum number of eventsNone |
68 |
5. Include endpointsNone |
68 |
6. Filter based on genotype QC (FinnGen only) |
57 |
Control definitions (FinnGen only)
- Control exclude
- F5_SUBSNOALCO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F10-F19
- Name in latin
- Perturbationes mentis et modi se gerendi ex usu cocaini
Similar endpoints
↥List of similar endpoints to
Mental and behavioural disorders due to cocaine
based on the number of shared cases.
Similar with more cases:
- Substance use, excluding alcohol
- Substance abuse, excluding more controls
- Substance abuse
- Mental and behavioural disorders due to psychoactive substance use
- Any mental disorder
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 540 | 155 | 381 |
| Only index persons | 457 | 137 | 320 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.00 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 30.18 | 29.30 | 30.44 |
| Only index persons | 29.08 | 27.60 | 29.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 57 | 22 | 35 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 31.60 | 27.61 | 34.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 64
- Matched controls
- 640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N05AH04
ATC
quetiapine; oral
11.0
21.5
37
71
N05BA04
ATC
oxazepam; oral
9.9
19.6
39
87
P19
ICPC
Drug abuse
245.2
18.5
18
*
N05BA01
ATC
diazepam; systemic, rectal
10.3
17.8
26
40
B18.2
ICD-10 Finland
Chronic viral hepatitis C
+∞
17.5
16
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
29.6
16.6
22
11
F14.1
ICD-10 Finland
Mental and behavioural disorders due to use of cocaine, harmful use
+∞
16.3
15
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
23.1
15.3
22
14
F15.2
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome
+∞
15.2
14
*
N05CF01
ATC
zopiclone; oral
7.6
15.1
34
83
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
29.2
14.4
19
9
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
8.6
14.2
23
39
N05AH03
ATC
olanzapine; systemic
16.4
14.0
23
21
F29
ICD-10 Finland
Unspecified nonorganic psychosis
23.9
13.5
19
11
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
7.6
12.9
24
47
F19.29
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances UNS
+∞
12.9
12
*
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
34.8
12.8
16
6
N05AA02
ATC
levomepromazine; systemic
34.8
12.8
16
6
P29
ICPC
Psychological sympt/compl other
7.9
12.7
22
40
N03AG01
ATC
valproic acid; systemic, rectal
18.7
12.5
19
14
N07BB01
ATC
disulfiram; oral
25.0
12.4
17
9
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
13.0
11.7
21
23
F60.9
ICD-10 Finland
Personality disorder, unspecified
53.4
11.4
13
*
IGY02
NOMESCO Finland
Psychiatric monitoring contact
18.7
11.3
17
12
Z3231
NOMESCO Finland
Registered nurse
5.8
11.1
32
94
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
14.2
10.6
18
17
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
21.2
10.5
15
9
Z2446
NOMESCO Finland
Social worker
12.3
10.4
19
21
X59
ICD-10 Finland
Exposure to unspecified factor
5.5
10.4
30
88
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
65.2
10.0
11
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
6.0
9.9
23
55
N06AB04
ATC
citalopram; systemic
5.8
9.9
24
60
Z2221
NOMESCO Finland
Medical doctor
5.3
9.8
31
97
N05CD07
ATC
temazepam; oral
11.4
9.6
18
21
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
+∞
9.6
9
*
F19.20
ICD-10 Finland
Addiction relationship caused by several drugs in combination and by other psychoactive substances currently independent
+∞
9.6
9
*
F15.1
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, harmful use
+∞
9.6
9
*
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
43.5
9.4
11
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
28.9
9.3
12
5
N03AE01
ATC
clonazepam; systemic
14.6
9.1
15
13
ZY010
NOMESCO Finland
Hospital outpatient
11.1
9.0
17
20
F10.20
ICD-10 Finland
Alcohol dependence currently independent
17.7
8.6
13
9
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
17.7
8.6
13
9
F13.25
ICD-10 Finland
Addiction caused by sedative and hypnotic continuous use
103.1
8.6
9
*
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
12.7
8.6
15
15
F13.29
ICD-10 Finland
Addiction caused by sedative and hypnotic UNS
+∞
8.5
8
*
F12.1
ICD-10 Finland
Mental and behavioural disorders due to use of cannabinoids, harmful use
+∞
8.5
8
*
F13.20
ICD-10 Finland
Addiction relationship caused by sedatives and hypnotics currently independent
+∞
8.5
8
*
P18
ICPC
Medication abuse
+∞
8.5
8
*
N05AX08
ATC
risperidone; systemic
9.6
8.4
17
23
N05AA01
ATC
chlorpromazine; systemic, rectal
38.8
8.3
10
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
11.8
8.3
15
16
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
13.4
8.3
14
13
F39
ICD-10 Finland
Unspecified mood [affective] disorder
18.1
8.1
12
8
N06AB06
ATC
sertraline; oral
5.4
8.1
20
50
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
9.8
8.0
16
21
AA1AD
NOMESCO Finland
CT of head and brain
4.6
7.8
26
83
F14.00
ICD-10 Finland
Intoxication caused by cocaine uncomplicated
+∞
7.4
7
*
F11.25
ICD-10 Finland
Relationship caused by opiates continuously used
+∞
7.4
7
*
F11.22
ICD-10 Finland
Addiction-induced dependence is currently independent but uses substitute intermittent medication
+∞
7.4
7
*
3042A
ICD-9 Finland
Drug dependence, Cocaine dependence
+∞
7.4
7
*
F19.21
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances currently independent but staying in a controlling environment
+∞
7.4
7
*
F60.2
ICD-10 Finland
Dissocial personality disorder
+∞
7.4
7
*
IGV01
NOMESCO Finland
Psychiatric network contact
23.3
7.4
10
5
F61.0
ICD-10 Finland
Mixed personality disorders
34.3
7.4
9
*
N05AD01
ATC
haloperidol; systemic
34.3
7.4
9
*
N03AX09
ATC
lamotrigine; oral
11.3
7.2
13
14
N06AX16
ATC
venlafaxine; oral
4.7
7.2
21
60
N05AH02
ATC
clozapine; systemic
19.4
7.0
10
6
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
44.9
6.9
8
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
44.9
6.9
8
*
ZXD10
NOMESCO Finland
Scheduled procedure
4.0
6.9
30
115
N06AA06
ATC
trimipramine; systemic
25.7
6.9
9
*
N05BE01
ATC
buspirone; oral
16.6
6.6
10
7
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
77.2
6.6
7
*
N05BA02
ATC
chlordiazepoxide; systemic
77.2
6.6
7
*
ZXE00
NOMESCO Finland
One hour or less
3.8
6.5
34
147
N05BA12
ATC
alprazolam; oral
8.2
6.5
14
21
F31.8
ICD-10 Finland
Other bipolar affective disorders
30.0
6.4
8
*
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
30.0
6.4
8
*
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
+∞
6.3
6
*
Z72.2
ICD-10 Finland
Drug use
+∞
6.3
6
*
F11.21
ICD-10 Finland
Addiction-indiced dependence caused by opiates currently independent but staying in controlling environment
+∞
6.3
6
*
F14.30
ICD-10 Finland
Withdrawal symptoms caused by cocaine uncomplicated
+∞
6.3
6
*
F12.20
ICD-10 Finland
Dependence caused by cannabis currently independent
+∞
6.3
6
*
F19.30
ICD-10 Finland
Withdrawal symptoms caused by several drugs in combination and by other psychoactive substances uncomplicated
+∞
6.3
6
*
F19.9
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, unspecified mental and behavioural disorder
+∞
6.3
6
*
N06AX11
ATC
mirtazapine; oral
3.7
6.2
31
129
C07AA05
ATC
propranolol; systemic
4.0
6.2
23
78
F20.9
ICD-10 Finland
Schizophrenia, unspecified
17.1
6.1
9
6
R07.4
ICD-10 Finland
Chest pain, unspecified
3.9
6.1
24
85
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
6.7
6.0
15
28
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
16
6
34.76
12.78
3.9
1.2
—
—
—
0
0
21
42
6.95
10.93
4.5
1.4
0.28
0.45
mg/l
0.53
14
20
19
32
7.98
8.20
3.6
4.3
5.81
5.93
kpa
0.23
19
32
15
20
9.43
7.42
3.9
3.3
24.53
24.57
mmol/l
0.02
15
20
11
8
16.24
7.19
2.1
1.1
—
—
—
0
0
10
6
19.37
7.00
4.0
4.8
410.40
280.67
umol/l
—
10
6
16
28
7.25
6.70
2.4
2.6
5.02
4.38
kpa
0.39
16
28
19
53
4.68
6.64
10.7
9.6
104.11
104.23
mmol/l
0.05
19
53
17
33
6.62
6.62
2.1
1.2
—
—
—
0
0
15
26
7.19
6.32
3.8
5.8
25.50
24.87
mmol/l
0.25
15
26
16
41
4.87
6.15
7.7
7.0
1.76
1.03
mmol/l
1.11
16
41
8
5
17.97
5.56
31.5
19.6
1388.25
1197.60
nmol/l
—
8
5
8
5
17.97
5.56
25.0
13.4
887.75
765.00
nmol/l
—
8
5
51
312
4.12
5.35
19.1
8.9
4.43
3.96
e9/l
0.56
40
270
19
64
3.80
5.07
3.6
2.8
3.86
1.51
e6/l
—
7
28
43
244
3.32
4.92
6.8
6.8
10.75
11.72
umol/l
0.27
43
236
11
18
7.13
4.85
2.5
5.4
132.18
127.78
g/l
0.14
11
18
33
168
2.99
4.44
2.3
1.7
96.31
95.70
pmol/l
0.03
21
82
28
132
2.99
4.30
4.9
3.2
1.02
1.02
kg/l
0.56
16
87
27
126
2.98
4.20
4.0
2.6
—
—
—
0
0
27
127
2.95
4.13
4.6
2.7
0.01
0.21
e6/l
1.88
18
96
25
114
2.96
4.03
3.4
2.4
—
—
—
0
0
21
91
2.95
3.66
3.8
3.4
127.00
41.56
ng/l
0.45
13
58
18
74
2.99
3.42
3.8
2.6
1.00
0.66
e6/l
—
6
39
9
19
5.33
3.38
2.8
2.2
2.69
2.23
%
—
9
19
9
23
4.37
2.90
1.4
1.3
—
—
—
0
0
7
14
5.47
2.81
3.3
2.7
179.14
277.24
ug/l
—
7
14
8
20
4.41
2.67
11.4
11.9
25.50
23.72
mmol/l
—
8
20
0
66
0.00
2.60
0.0
1.7
—
3.64
—
0
48
7
18
4.23
2.32
2.0
1.6
—
—
—
0
0
11
42
2.95
2.28
3.7
2.2
—
—
—
0
0
20
106
2.29
2.23
2.7
2.4
—
—
—
0
0
8
25
3.50
2.18
10.8
11.6
1.57
1.63
%
—
8
25
8
25
3.50
2.18
10.8
11.6
0.51
0.68
%
—
8
25
20
108
2.24
2.12
2.2
1.8
1.38
0.81
mg/l
0.64
12
83
59
510
3.00
1.91
25.1
13.5
3.89
3.95
mmol/l
0.82
59
498
5
13
4.07
1.75
1.0
1.5
4.88
3.64
mmol/l
—
5
13
5
13
4.07
1.75
1.4
1.2
—
—
—
0
0
19
111
2.01
1.62
4.9
4.1
12.34
9.59
mg/mmol
0.10
13
71
6
20
3.20
1.62
1.8
1.2
—
429.12
miu/ml
—
0
8
36
263
1.84
1.56
4.1
3.0
0.00
0.00
estimate
—
5
50
5
15
3.52
1.55
1.4
1.5
678.60
622.80
mg/l
—
5
15
51
422
2.03
1.44
6.3
3.2
41.43
43.12
u/l
0.10
51
411
5
17
3.10
1.38
2.2
1.9
65.80
91.82
%
—
5
17
36
270
1.76
1.37
4.1
3.2
0.00
0.00
estimate
—
5
48
36
270
1.76
1.37
4.1
3.1
0.00
0.00
estimate
—
5
51
11
56
2.16
1.31
2.1
1.5
—
—
—
0
0
11
57
2.12
1.26
2.0
1.5
—
—
—
0
0
12
66
2.01
1.18
2.2
2.3
31.58
30.23
s
0.39
12
66
13
74
1.95
1.17
2.7
1.6
—
—
—
0
0
12
68
1.94
1.09
3.9
2.4
—
—
—
0
0
21
145
1.67
1.02
1.0
1.4
0.72
2.04
u/ml
—
5
38
54
474
1.89
1.02
6.2
4.1
38.92
37.52
mmol/mol
0.41
49
454
0
28
0.00
1.00
0.0
1.6
—
—
—
0
0
8
46
1.84
0.86
11.4
20.3
1.00
1.06
mmol/l
—
8
40
22
162
1.55
0.81
4.4
2.7
479.15
23.46
ng/l
0.46
15
96
0
24
0.00
0.81
0.0
1.7
—
—
—
0
0
9
58
1.64
0.73
4.0
2.3
—
—
—
0
0
28
225
1.43
0.66
3.8
3.0
—
—
estimate
—
0
0
0
21
0.00
0.61
0.0
1.6
—
45.62
—
0
21
6
38
1.64
0.56
1.2
1.3
—
—
—
0
0
12
88
1.45
0.44
1.2
1.3
2.54
5.17
u/ml
—
5
42
0
15
0.00
0.42
0.0
1.8
—
—
—
0
0
0
15
0.00
0.42
0.0
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
2.8
—
24.69
—
0
16
18
148
1.30
0.34
2.0
1.7
—
—
—
0
0
5
40
1.27
0.23
1.2
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
8
72
1.13
0.17
2.1
1.5
—
—
—
0
0
23
212
1.13
0.12
4.0
2.8
0.00
0.02
estimate
—
5
43
13
141
0.90
0.06
5.7
2.8
0.00
0.00
estimate
—
5
46
43
441
0.92
0.05
4.6
3.7
—
—
—
0
0
5
57
0.87
0.00
1.8
1.6
1497.34
914.85
mu/l
—
5
45
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
45.83
—
0
6
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.0
—
121.33
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
-0.00
0.0
2.8
—
106.33
—
0
6
0
6
0.00
-0.00
0.0
2.0
—
6.82
—
0
6
0
6
0.00
-0.00
0.0
6.7
—
12.88
—
0
6
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
13.00
—
0
8
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
9.56
—
0
9
0
5
0.00
-0.00
0.0
6.0
—
46.60
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint F5_COCAINE and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_COCAINE | 5.817 [3.31, 10.22] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 271 males with F5_COCAINE died.
Mortality risk
Mortality risk for people of age
years, who have F5_COCAINE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.888% |
| 5 | No data | 6.195% |
| 10 | No data | 14.98% |
| 15 | No data | 26.713% |
| 20 | No data | 42.334% |
Relationships between endpoints
↥Index endpoint: F5_COCAINE – Mental and behavioural disorders due to cocaine
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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