Other and unspecified syphilis, including avohilmo

AB1_SYPHILIS_NOS_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 A53
  • Hospital discharge: ICD-10 A53
  • Hospital discharge: ICD-9 097
  • Hospital discharge: ICD-8 097
  • Cause of death: ICD-10 A53
  • Cause of death: ICD-9 097
  • Cause of death: ICD-8 097

3 out of 7 registries used, show all original rules.

154

4. Check minimum number of events

None

154

5. Include endpoints

None

154

6. Filter based on genotype QC (FinnGen only)

129

Control definitions (FinnGen only)

Control exclude
AB1_SEXUAL_TRANSMISSION

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF13

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 129 31 98
Unadjusted period prevalence (%) 0.04 0.01 0.04
Median age at first event (years) 45.22 39.60 46.99

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
149
Matched controls
1490
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A53.9
ICD-10 Finland
Syphilis, unspecified
+∞
126.8
103
*
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
32.1
98.0
77
48
WW200
NOMESCO Finland
Immunization
36.0
72.2
49
20
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
127.5
43.6
45
5
A56.3
ICD-10 Finland
Chlamydial infection of anus and rectum
+∞
40.5
37
*
Y25
ICPC
Fear sexually transm disease male
13.1
35.1
38
38
A51.0
ICD-10 Finland
Primary genital syphilis
+∞
34.8
32
*
A53.0
ICD-10 Finland
Latent syphilis, unspecified as early or late
+∞
33.6
31
*
B24
ICD-10 Finland
Unspecified human immunodeficiency virus [HIV] disease
74.4
22.6
25
*
A54.6
ICD-10 Finland
Gonococcal infection of anus and rectum
+∞
22.5
21
*
Z25.1
ICD-10 Finland
Need for immunization against influenza
10.3
21.3
26
30
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
7.0
20.3
36
65
A51.9
ICD-10 Finland
Early syphilis, unspecified
+∞
20.3
19
*
A54.5
ICD-10 Finland
Gonococcal pharyngitis
229.2
20.1
20
*
A51.3
ICD-10 Finland
Secondary syphilis of skin and mucous membranes
+∞
19.2
18
*
Z3231
NOMESCO Finland
Registered nurse
4.6
19.0
71
245
Z2221
NOMESCO Finland
Medical doctor
4.5
17.7
64
214
Z71.8
ICD-10 Finland
Other specified counselling
4.2
16.8
80
324
Y70
ICPC
Syphilis male
+∞
15.9
15
*
A56.0
ICD-10 Finland
Chlamydial infection of lower genitourinary tract
26.9
15.6
21
9
Z21
ICD-10 Finland
Asymptomatic human immunodeficiency virus [HIV] infection status
82.6
13.8
15
*
A54.0
ICD-10 Finland
Gonococcal infection of lower genitourinary tract without periurethral or accessory gland abscess
+∞
13.8
13
*
09710
ICD-8 Finland
Other syphilis and not specified, Latent syphilis, unspecified
+∞
11.6
11
*
A63.0
ICD-10 Finland
Anogenital (venereal) warts
15.6
11.3
18
13
Z29.2
ICD-10 Finland
Other prophylactic chemotherapy
118.0
10.6
11
*
B23.8
ICD-10 Finland
HIV disease resulting in other specified conditions
106.5
9.5
10
*
B23.0
ICD-10 Finland
Acute HIV infection syndrome
+∞
9.5
9
*
UJF30
NOMESCO Finland
Ileoscopy through colon
4.5
9.0
24
61
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.2
8.6
43
169
A52.1
ICD-10 Finland
Symptomatic neurosyphilis
+∞
8.4
8
*
A52.9
ICD-10 Finland
Late syphilis, unspecified
+∞
8.4
8
*
A56.4
ICD-10 Finland
Chlamydial infection of pharynx
+∞
8.4
8
*
TAB00
NOMESCO Finland
Lumbar puncture
6.6
8.0
20
34
WX110, ,
SPAT
4.7
8.0
20
48
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.7
7.5
57
278
Z76.0
ICD-10 Finland
Issue of repeat prescription
2.7
7.5
54
257
J01MA02
ATC
ciprofloxacin; systemic
2.6
7.4
65
341
A53
ICD-10 Finland
Other and unspecified syphilis
+∞
7.3
7
*
Y71
ICPC
Gonorrhoea male
+∞
7.3
7
*
D01
ICPC
Abdominal pain/cramps general
3.3
6.6
27
93
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.7
6.5
41
181
S02.51
ICD-10 Finland
Fracture of tooth, open
3.8
6.4
21
62
ZX114
NOMESCO Finland
Intramuscular
11.8
6.4
11
10
A54.9
ICD-10 Finland
Gonococcal infection, unspecified
+∞
6.3
6
*
A52.2
ICD-10 Finland
Asymptomatic neurosyphilis
+∞
6.3
6
*
A52.3
ICD-10 Finland
Neurosyphilis, unspecified
+∞
6.3
6
*
A51.5
ICD-10 Finland
Early syphilis, latent
+∞
6.3
6
*
Z2446
NOMESCO Finland
Social worker
4.1
6.0
17
45

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
104
34
98.97
173.54
11.1
2.0
11.25
—
titre
—
56
0
46
13
50.74
75.79
3.3
2.2
30.88
33.75
%
0.28
46
13
98
148
17.42
72.30
3.8
1.8
—
—
—
0
0
58
41
22.53
67.78
7.9
4.7
176.27
266.69
mg/l
0.48
52
26
89
208
9.14
42.10
6.3
1.7
—
—
—
0
0
64
142
7.15
30.41
5.5
1.7
—
—
—
0
0
90
421
3.87
14.85
5.8
3.4
24.87
195.54
e6/l
0.99
50
295
74
312
3.73
14.13
7.1
2.0
—
—
—
0
0
84
405
3.46
12.65
11.6
6.1
—
—
—
0
0
98
522
3.56
12.50
4.1
3.3
6.29
6.07
ph
0.80
33
323
75
351
3.29
11.62
10.1
6.1
—
—
—
0
0
57
242
3.20
10.16
2.4
1.7
—
—
—
0
0
89
489
3.04
10.00
5.7
4.8
38.13
36.68
g/l
1.56
89
470
48
189
3.27
9.64
3.6
2.4
1.76
1.68
e6/l
0.03
13
87
15
12
13.74
9.09
1.1
1.2
—
—
—
0
0
14
10
15.29
8.89
1.1
1.1
—
—
—
0
0
110
707
3.12
8.85
14.8
11.5
3.64
4.22
e9/l
1.97
96
623
17
19
9.94
8.81
1.1
1.1
—
—
—
0
0
103
642
2.96
8.71
4.3
3.5
0.00
0.00
estimate
—
8
136
102
634
2.93
8.64
4.2
3.4
0.00
0.00
estimate
—
8
136
22
55
4.52
8.41
1.0
1.4
268.60
273.35
miu/ml
—
5
35
103
649
2.90
8.40
4.3
3.5
0.00
0.00
estimate
—
6
125
19
31
6.86
7.85
1.3
1.2
—
—
—
0
0
101
652
2.70
7.48
13.8
7.4
0.19
0.19
e9/l
0.05
94
580
98
629
2.63
7.25
14.0
6.9
0.58
0.59
e9/l
0.32
90
551
18
31
6.45
7.18
1.2
1.1
—
—
—
0
0
98
633
2.60
7.10
14.0
6.9
0.04
0.04
e9/l
0.16
90
554
87
532
2.53
7.07
16.5
11.3
0.00
0.00
e9/l
0.50
75
436
16
25
7.03
6.85
1.1
1.1
11.11
3.76
e6/l
—
9
17
62
328
2.52
6.83
3.9
2.6
0.10
0.40
e6/l
2.32
41
234
68
376
2.49
6.81
3.8
2.7
16.46
245.40
e6/l
0.71
49
283
16
26
6.76
6.68
1.1
1.2
65.11
376.33
e6/l
—
9
18
98
645
2.52
6.63
14.0
7.0
2.12
1.91
e9/l
1.38
90
578
122
902
2.95
6.34
9.8
8.6
74.70
77.66
u/l
0.53
122
864
69
415
2.23
5.40
3.4
3.2
9.21
9.00
mmol/l
0.10
64
365
73
451
2.21
5.33
1.9
1.9
94.87
96.76
pmol/l
0.14
36
231
44
221
2.41
5.23
3.2
2.5
590.33
555.73
mosm/kgh2o
0.42
39
196
26
101
2.91
5.14
1.2
1.2
—
—
—
0
0
14
28
5.40
5.09
2.2
3.5
1.13
2.26
index
—
8
16
20
72
3.05
4.49
6.8
2.7
—
—
—
0
0
35
169
2.40
4.48
1.6
2.6
—
—
—
0
0
48
270
2.15
4.27
1.6
1.5
18.61
20.29
nmol/l
0.48
42
233
29
133
2.47
4.13
1.1
1.2
—
—
—
0
0
22
89
2.73
4.02
1.5
1.7
0.14
0.35
mg/l
—
8
42
40
220
2.12
3.72
3.0
3.1
150.62
659.49
ng/l
0.58
29
161
38
209
2.10
3.52
1.8
1.9
2.58
2.91
mg/l
0.42
29
187
29
143
2.28
3.51
1.3
1.9
—
—
—
0
0
126
1058
2.24
3.22
27.2
17.1
13.30
13.40
%
0.38
126
1051
11
30
3.87
3.16
1.4
1.4
194.00
151.29
au/ml
—
5
7
13
48
2.87
2.80
2.1
2.7
—
—
—
0
0
27
142
2.10
2.78
1.4
1.6
—
—
—
0
0
53
352
1.78
2.75
1.9
2.4
—
—
—
0
0
46
293
1.82
2.73
1.5
1.3
0.79
1.18
u/ml
—
8
85
12
45
2.81
2.52
1.6
1.2
—
—
—
0
0
9
28
3.35
2.35
1.1
1.4
219.00
230.64
u/ml
—
9
11
18
87
2.22
2.28
2.0
2.1
—
—
—
0
0
13
55
2.49
2.19
1.3
1.4
—
—
—
0
0
87
695
1.61
2.10
4.8
3.8
—
29.44
—
0
9
40
264
1.70
2.06
1.5
1.4
2.40
2.39
g/l
0.02
20
177
38
248
1.71
2.03
3.3
2.7
—
—
—
0
0
136
1233
2.18
1.98
16.2
14.2
29.50
23.37
mg/l
1.20
114
1007
9
33
2.84
1.97
1.3
1.4
—
—
—
0
0
26
153
1.85
1.96
2.2
2.4
109.44
129.97
ug/g
0.20
21
122
33
210
1.73
1.93
1.6
1.6
—
—
—
0
0
19
101
2.01
1.91
5.3
8.1
1.15
1.29
mmol/l
0.57
19
101
44
599
0.62
1.85
2.4
2.9
—
—
—
0
0
9
35
2.67
1.83
1.0
1.1
—
—
—
0
0
19
104
1.95
1.77
7.0
8.5
—
—
—
0
0
14
68
2.17
1.76
1.4
1.2
—
—
—
0
0
6
18
3.43
1.76
1.0
1.3
—
—
—
0
0
47
340
1.56
1.66
1.4
1.4
—
—
—
0
0
18
105
1.81
1.41
2.0
2.0
—
—
—
0
0
17
98
1.83
1.38
2.0
2.5
0.26
0.23
g/l
0.92
17
89
9
42
2.21
1.36
1.0
1.2
—
—
—
0
0
64
512
1.44
1.35
2.6
2.8
—
—
estimate
—
0
0
18
108
1.76
1.29
2.0
2.0
—
—
—
0
0
13
70
1.94
1.28
5.0
2.6
22.05
24.48
mmol/l
1.87
13
70
14
78
1.88
1.26
1.2
1.2
87.11
373.79
u/ml
0.76
14
68
25
357
0.64
1.22
3.6
3.2
—
—
—
0
0
18
111
1.71
1.18
2.0
1.9
—
—
—
0
0
18
111
1.71
1.18
2.0
1.9
—
—
—
0
0
0
34
0.00
1.17
0.0
2.0
—
7.42
—
0
34
12
65
1.92
1.17
9.8
3.9
154.33
86.50
ng/l
0.65
12
60
20
128
1.65
1.16
1.5
1.4
—
—
—
0
0
127
1171
1.57
1.14
6.9
4.4
5.98
5.92
mmol/l
0.15
122
1092
7
31
2.32
1.12
1.1
1.3
—
—
—
0
0
123
1308
0.66
1.05
12.7
12.1
—
—
—
0
0
5
22
2.32
1.04
1.2
1.0
—
—
—
0
0
97
860
1.37
1.01
3.5
3.6
14.25
14.72
pmol/l
1.06
91
793
35
451
0.71
0.99
3.2
3.2
32.01
40.81
ng/l
0.25
20
292
7
36
1.99
0.98
1.0
1.3
—
—
—
0
0
17
110
1.62
0.95
2.1
1.9
—
—
—
0
0
140
1338
1.77
0.95
25.2
17.1
86.51
79.44
umol/l
0.54
140
1326
17
111
1.60
0.92
7.2
3.4
7.36
7.39
ph
—
10
71
40
316
1.36
0.86
7.6
3.7
7.40
7.39
ph
0.15
25
220
44
353
1.35
0.86
3.9
3.4
58.88
40.07
mg/l
0.19
30
233
6
32
1.91
0.82
1.5
2.1
—
—
—
0
0
0
27
0.00
0.78
0.0
3.6
—
58.69
—
0
27
6
34
1.80
0.77
1.0
3.4
26.67
52.76
u/ml
—
6
34
44
359
1.32
0.77
4.6
4.0
8.99
6.47
mg/mmol
0.14
31
236
36
285
1.35
0.77
2.9
3.7
1.01
1.02
kg/l
1.66
26
186
7
39
1.83
0.73
1.7
1.7
—
4.83
—
0
13
17
118
1.50
0.73
5.1
12.5
96.86
95.84
%
0.70
17
112
134
1284
1.43
0.61
7.9
5.1
2.75
2.82
mmol/l
0.46
128
1214
0
22
0.00
0.60
0.0
1.9
—
—
—
0
0
0
22
0.00
0.60
0.0
1.7
—
2.50
—
0
14
0
22
0.00
0.60
0.0
1.7
—
5.09
—
0
22
0
22
0.00
0.60
0.0
1.7
—
8.65
—
0
22
39
324
1.28
0.59
4.9
5.0
—
—
—
0
0
8
54
1.51
0.58
1.3
1.1
—
—
—
0
0
49
421
1.24
0.56
1.7
1.9
—
—
—
0
0
18
134
1.39
0.56
5.2
11.4
7.40
7.41
ph
—
7
77
9
59
1.56
0.56
2.4
2.3
0.60
0.62
%
—
9
59
9
61
1.51
0.55
2.4
2.3
1.40
1.45
%
—
9
61
19
144
1.37
0.54
1.3
1.2
—
—
—
0
0
7
47
1.51
0.48
1.0
1.3
—
—
—
0
0
18
229
0.76
0.47
1.3
1.4
—
—
—
0
0
56
500
1.19
0.43
7.9
12.0
1.14
1.20
inr
0.35
44
415
5
31
1.63
0.43
2.4
2.4
59.86
63.00
%
—
5
31
17
214
0.77
0.41
1.2
1.2
40.80
25.00
iu/ml
—
7
54
0
16
0.00
0.41
0.0
4.6
—
3.52
—
0
16
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
26
310
0.80
0.41
3.9
5.6
—
—
—
0
0
142
1389
1.47
0.41
29.4
21.3
42.23
42.29
%
0.06
142
1379
142
1389
1.47
0.41
29.1
21.1
142.07
142.37
g/l
0.09
142
1380
142
1389
1.47
0.41
28.9
20.9
90.97
90.25
fl
1.05
142
1381
142
1389
1.47
0.41
28.9
20.9
30.63
30.33
pg
1.06
142
1381
0
17
0.00
0.41
0.0
1.5
—
47.94
—
0
17
0
17
0.00
0.41
0.0
4.6
—
4.02
—
0
17
0
17
0.00
0.41
0.0
2.0
—
—
—
0
0
0
17
0.00
0.41
0.0
3.8
—
1.17
—
0
11
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
2.5
—
46.16
—
0
19
0
19
0.00
0.39
0.0
2.1
—
0.16
—
0
14
0
19
0.00
0.39
0.0
4.9
—
8.26
—
0
19
126
1216
1.23
0.36
6.2
4.0
1.39
1.37
mmol/l
0.15
119
1147
14
177
0.77
0.35
1.4
1.5
—
—
—
0
0
28
325
0.83
0.34
3.1
2.6
0.62
0.71
ug/l
0.38
19
157
34
386
0.85
0.33
3.2
2.7
0.00
0.00
estimate
—
5
107
131
1272
1.25
0.33
7.5
4.7
4.48
4.66
mmol/l
1.54
125
1207
7
96
0.72
0.32
1.4
1.4
—
—
—
0
0
9
74
1.23
0.26
1.3
1.2
—
—
—
0
0
6
85
0.69
0.24
1.2
1.1
1.05
0.87
g/l
—
6
85
6
85
0.69
0.24
1.2
1.1
1.45
1.47
g/l
—
6
85
130
1269
1.19
0.24
7.6
4.6
1.29
1.35
mmol/l
1.23
124
1201
31
345
0.87
0.23
3.1
3.4
0.00
0.01
estimate
—
7
133
5
42
1.20
0.21
10.6
14.5
0.84
0.82
%
—
5
36
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
4.9
—
73.54
—
0
12
0
13
0.00
0.21
0.0
3.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
9
112
0.79
0.21
1.7
1.6
—
—
—
0
0
6
48
1.26
0.20
9.2
13.0
1.53
1.48
%
—
6
41
0
14
0.00
0.20
0.0
4.5
—
33.00
—
0
14
8
68
1.19
0.17
1.3
1.6
—
—
—
0
0
7
85
0.81
0.15
2.0
1.9
195.71
230.24
pmol/l
—
7
80
47
495
0.93
0.13
3.4
3.2
0.00
0.01
estimate
—
6
116
35
328
1.09
0.12
2.1
2.5
378.86
355.17
umol/l
0.90
35
288
5
44
1.14
0.10
1.2
1.1
—
—
—
0
0
5
44
1.14
0.10
1.2
1.1
—
—
—
0
0
5
46
1.09
0.09
1.6
1.5
5.96
23.07
iu/l
—
5
36
5
64
0.77
0.08
1.4
2.6
213.80
179.40
ng/l
—
5
56
19
181
1.06
0.03
1.2
1.3
1.21
8.07
u/ml
—
9
75
11
102
1.08
0.03
12.3
5.8
9.77
8.78
mmol/l
0.20
11
96
26
262
0.99
0.00
2.2
1.7
0.96
1.06
mg/l
0.13
18
202
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.42
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
87
0.92
-0.00
1.3
2.2
6.16
6.21
ug/l
—
8
80
0
8
0.00
-0.00
0.0
1.3
—
0.00
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
28.04
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
11.99
—
0
7
0
5
0.00
-0.00
0.0
4.4
—
12.80
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
0.31
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
96
0.93
-0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
3.60
—
0
5
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
235.80
—
0
5
0
6
0.00
-0.00
0.0
9.2
—
0.73
—
0
6
0
7
0.00
-0.00
0.0
2.1
—
3.19
—
0
7
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
6
59
1.02
-0.00
1.0
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: AB1_SYPHILIS_NOS_WIDE – Other and unspecified syphilis, including avohilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).