No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
119 |
4. Check minimum number of eventsNone |
119 |
5. Include endpointsNone |
119 |
6. Filter based on genotype QC (FinnGen only) |
98 |
Control definitions (FinnGen only)
- Control exclude
- AB1_SEXUAL_TRANSMISSION
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Other and unspecified syphilis
based on the number of shared cases.
Similar with more cases:
- Other and unspecified syphilis, including avohilmo
- Syphilis, including avohilmo
- Syphilis
- Infections with a predominantly sexual mode of transmission
- Infections with a predominantly sexual mode of transmission, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 893 | 369 | 469 |
| Only index persons | 694 | 310 | 384 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 42.22 | 37.40 | 47.04 |
| Only index persons | 40.34 | 35.56 | 44.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 98 | 26 | 72 |
| Unadjusted period prevalence (%) | 0.03 | 0.01 | 0.03 |
| Median age at first event (years) | 45.92 | 40.85 | 47.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 115
- Matched controls
- 1150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A53.9
ICD-10 Finland
Syphilis, unspecified
+∞
91.1
75
*
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
28.8
65.8
52
32
WW200
NOMESCO Finland
Immunization
39.3
61.5
41
16
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
179.5
37.2
37
*
A53.0
ICD-10 Finland
Latent syphilis, unspecified as early or late
+∞
31.7
29
*
A56.3
ICD-10 Finland
Chlamydial infection of anus and rectum
+∞
26.0
24
*
B24
ICD-10 Finland
Unspecified human immunodeficiency virus [HIV] disease
94.7
21.6
23
*
A51.0
ICD-10 Finland
Primary genital syphilis
+∞
20.4
19
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
8.7
20.2
30
45
Z2221
NOMESCO Finland
Medical doctor
5.4
17.8
55
168
A51.9
ICD-10 Finland
Early syphilis, unspecified
+∞
16.0
15
*
Z3231
NOMESCO Finland
Registered nurse
4.5
14.4
56
200
Y25
ICPC
Fear sexually transm disease male
15.7
13.6
22
17
A54.5
ICD-10 Finland
Gonococcal pharyngitis
145.2
12.7
13
*
Z21
ICD-10 Finland
Asymptomatic human immunodeficiency virus [HIV] infection status
145.2
12.7
13
*
A56.0
ICD-10 Finland
Chlamydial infection of lower genitourinary tract
42.6
12.5
15
*
09710
ICD-8 Finland
Other syphilis and not specified, Latent syphilis, unspecified
+∞
11.7
11
*
Z71.8
ICD-10 Finland
Other specified counselling
3.7
11.0
60
261
A54.6
ICD-10 Finland
Gonococcal infection of anus and rectum
+∞
10.6
10
*
Z25.1
ICD-10 Finland
Need for immunization against influenza
11.0
9.7
18
19
B23.8
ICD-10 Finland
HIV disease resulting in other specified conditions
96.9
8.5
9
*
Y70
ICPC
Syphilis male
+∞
8.4
8
*
A54.0
ICD-10 Finland
Gonococcal infection of lower genitourinary tract without periurethral or accessory gland abscess
+∞
8.4
8
*
A51.3
ICD-10 Finland
Secondary syphilis of skin and mucous membranes
+∞
8.4
8
*
A52.1
ICD-10 Finland
Symptomatic neurosyphilis
+∞
8.4
8
*
TAB00
NOMESCO Finland
Lumbar puncture
7.4
8.1
19
30
S02.51
ICD-10 Finland
Fracture of tooth, open
4.4
6.9
19
50
UJF30
NOMESCO Finland
Ileoscopy through colon
4.4
6.5
18
47
Z29.2
ICD-10 Finland
Other prophylactic chemotherapy
73.8
6.5
7
*
A52.2
ICD-10 Finland
Asymptomatic neurosyphilis
+∞
6.3
6
*
ZX114
NOMESCO Finland
Intramuscular
13.5
6.2
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
54
54
17.97
52.04
7.8
2.2
—
—
—
0
0
54
56
17.29
50.78
8.1
2.4
—
—
—
0
0
60
145
7.56
26.68
6.9
2.2
—
—
—
0
0
55
134
6.95
23.87
6.5
2.1
—
—
—
0
0
46
134
5.05
15.46
20.6
6.0
0.98
0.99
mmol/l
0.17
46
123
71
389
3.16
8.26
6.2
5.0
38.17
36.28
g/l
1.93
71
373
82
507
3.15
7.37
4.4
3.6
0.00
0.00
estimate
—
6
109
81
504
3.05
7.08
4.3
3.5
0.00
0.00
estimate
—
6
109
87
565
3.22
7.00
14.2
12.0
3.65
4.32
e9/l
1.95
79
495
37
158
2.98
6.43
4.0
2.5
0.99
1.53
e6/l
—
10
72
10
10
10.81
5.65
1.1
1.1
—
—
—
0
0
38
176
2.73
5.60
3.9
2.4
1.52
1.03
e6/l
0.41
11
90
96
718
3.04
4.95
10.3
9.0
75.69
78.73
u/l
0.44
96
685
12
24
5.45
4.46
1.8
3.9
1.29
1.01
index
—
7
15
15
39
4.27
4.39
1.9
1.4
—
—
—
0
0
59
370
2.22
4.25
1.8
1.9
88.35
95.51
pmol/l
0.68
29
183
13
31
4.59
4.17
2.8
1.5
—
—
—
0
0
48
281
2.22
4.06
4.3
2.7
0.13
0.39
e6/l
1.50
31
204
7
14
5.25
2.77
2.7
2.1
—
—
—
0
0
31
175
2.06
2.74
3.2
3.3
152.26
239.24
ng/l
0.18
23
132
8
20
4.22
2.62
1.6
1.4
—
—
—
0
0
6
12
5.21
2.43
1.2
1.0
—
—
—
0
0
8
22
3.83
2.41
1.5
1.8
—
—
—
0
0
29
174
1.89
2.13
1.6
2.0
2.66
3.00
mg/l
0.36
23
156
95
814
1.96
2.01
28.8
18.8
13.29
13.45
%
0.63
95
809
5
11
4.70
1.96
1.2
2.2
—
—
—
0
0
6
17
3.66
1.86
1.5
1.5
—
—
—
0
0
6
17
3.66
1.86
1.5
1.5
—
—
—
0
0
5
12
4.30
1.84
1.0
1.0
—
—
—
0
0
32
208
1.75
1.80
2.0
2.5
—
—
—
0
0
15
75
2.15
1.79
2.1
2.9
0.26
0.23
g/l
0.70
15
67
14
68
2.21
1.79
2.1
1.7
—
—
—
0
0
14
69
2.17
1.73
1.8
4.1
65.67
69.79
ml/min/173m2
—
6
34
6
23
2.69
1.38
1.2
1.4
172.33
192.60
u/ml
—
6
10
80
687
1.54
1.30
3.7
3.1
—
—
—
0
0
26
365
0.63
1.26
3.2
3.4
37.26
43.07
ng/l
0.12
16
250
18
110
1.75
1.24
2.9
4.1
232.33
247.33
u/l
0.17
18
105
5
19
2.70
1.23
1.0
1.3
—
—
—
0
0
25
351
0.63
1.20
3.8
4.1
26.27
21.97
%
0.53
13
143
5
20
2.57
1.16
1.0
1.1
—
—
—
0
0
49
390
1.45
1.11
4.1
2.6
127.20
165.89
ug/l
0.52
49
374
9
46
2.04
1.06
1.3
1.3
—
—
—
0
0
9
49
1.91
1.01
1.0
1.0
—
—
—
0
0
38
293
1.44
1.00
4.7
4.1
9.70
7.51
mg/mmol
0.11
27
193
14
86
1.71
0.96
4.7
8.4
1.19
1.35
mmol/l
0.53
14
86
6
27
2.29
0.95
1.3
1.4
—
—
—
0
0
102
948
1.67
0.94
21.5
14.5
87.04
86.67
ml/min/173m2
0.06
95
875
6
28
2.20
0.93
1.0
1.2
—
—
—
0
0
6
28
2.20
0.93
1.0
1.2
—
—
—
0
0
103
969
1.60
0.77
16.9
15.1
26.75
24.65
mg/l
0.25
84
792
6
108
0.53
0.77
5.3
7.6
—
—
—
0
0
5
25
2.04
0.73
1.0
3.9
24.80
29.96
u/ml
—
5
25
9
58
1.60
0.72
6.3
2.7
21.71
24.67
mmol/l
—
9
58
27
212
1.36
0.63
3.3
3.9
1.01
1.02
kg/l
2.24
19
139
0
21
0.00
0.60
0.0
1.1
—
0.61
—
0
6
48
420
1.25
0.50
2.9
2.9
—
—
estimate
—
0
0
107
1031
1.54
0.48
26.5
18.9
88.99
80.05
umol/l
0.52
107
1021
13
172
0.72
0.45
1.2
1.3
45.93
27.21
iu/ml
—
6
45
8
55
1.49
0.44
14.3
4.1
207.37
92.28
ng/l
—
8
50
23
279
0.78
0.44
3.3
3.5
0.00
0.00
estimate
—
5
105
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
15.91
—
0
9
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
23
189
1.27
0.40
2.5
1.6
—
—
—
0
0
7
53
1.34
0.31
1.0
1.2
—
—
—
0
0
14
171
0.79
0.28
1.6
1.7
451.57
445.00
pmol/l
0.04
14
149
5
75
0.65
0.26
1.4
1.4
—
—
—
0
0
24
271
0.86
0.23
3.3
2.7
0.67
0.72
ug/l
0.15
16
137
0
11
0.00
0.21
0.0
1.5
—
12.91
—
0
11
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
15.18
—
0
12
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
6
52
1.16
0.19
2.8
2.5
1.02
1.44
%
—
6
52
5
67
0.73
0.17
1.4
2.3
6.92
6.07
ug/l
—
5
62
14
120
1.19
0.17
1.6
1.8
—
—
—
0
0
14
121
1.18
0.16
1.6
1.7
—
—
—
0
0
14
160
0.86
0.15
1.7
2.0
—
—
—
0
0
108
1063
1.26
0.15
30.2
22.8
4.62
4.68
e12/l
0.72
108
1046
108
1063
1.26
0.15
30.3
22.8
249.29
245.62
e9/l
0.31
108
1049
108
1063
1.26
0.15
30.7
23.2
42.14
42.04
%
0.08
108
1053
108
1063
1.26
0.15
30.4
22.9
141.64
141.21
g/l
0.10
108
1054
108
1063
1.26
0.15
30.2
22.7
91.41
90.51
fl
1.17
108
1055
7
88
0.78
0.15
1.4
1.4
—
—
—
0
0
16
147
1.10
0.07
1.3
1.3
1.10
9.59
u/ml
—
7
60
22
211
1.05
0.03
2.3
1.7
1.01
1.21
mg/l
0.25
17
161
96
952
1.05
0.02
6.4
4.2
1.36
1.37
mmol/l
0.06
91
890
26
266
0.97
0.00
2.2
2.6
382.31
350.05
umol/l
1.05
26
230
10
96
1.05
0.00
6.4
3.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
392.75
—
0
8
0
5
0.00
0.00
0.0
1.2
—
54.02
—
0
5
6
63
0.95
0.00
6.8
7.2
23.00
25.34
mmol/l
—
6
63
0
8
0.00
0.00
0.0
7.5
—
141.37
—
0
8
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
10.88
—
0
8
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
8.14
—
0
5
0
8
0.00
0.00
0.0
1.0
—
36.66
—
0
8
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
5
50
1.00
-0.00
1.4
3.0
213.80
213.70
ng/l
—
5
45
0
7
0.00
-0.00
0.0
1.3
—
266.14
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
53.83
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
202.43
—
0
7
5
52
0.96
-0.00
1.6
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
11.75
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint AB1_SYPHILIS_NOS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have AB1_SYPHILIS_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: AB1_SYPHILIS_NOS – Other and unspecified syphilis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data