No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1141 |
4. Check minimum number of eventsNone |
1141 |
5. Include endpointsNone |
1141 |
6. Filter based on genotype QC (FinnGen only) |
1033 |
Control definitions (FinnGen only)
- Control exclude
- M13_OSTEOCHONDRO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M80-M85
- Name in latin
- Aliae perturbationes densitatis et structurae ossium
Similar endpoints
↥List of similar endpoints to
Other disorders of bone density and structure
based on the number of shared cases.
Similar with more cases:
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8060 | 4419 | 3617 |
| Only index persons | 7643 | 4236 | 3407 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.10 |
| Only index persons | 0.14 | 0.16 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 39.96 | 45.13 | 33.56 |
| Only index persons | 39.69 | 44.77 | 33.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1033 | 672 | 361 |
| Unadjusted period prevalence (%) | 0.21 | 0.24 | 0.17 |
| Median age at first event (years) | 46.87 | 46.69 | 47.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1070
- Matched controls
- 10700
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M85.8
ICD-10 Finland
Other specified disorders of bone density and structure
820.6
307.7
377
7
M85.4
ICD-10 Finland
Solitary bone cyst
1173.6
204.1
193
*
M85.9
ICD-10 Finland
Disorder of bone density and structure, unspecified
855.4
154.4
148
*
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
27.5
121.9
84
33
M85.6
ICD-10 Finland
Other cyst of bone
1248.2
117.0
112
*
M85.0
ICD-10 Finland
Fibrous dysplasia (monostotic)
+∞
93.1
88
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
17.1
81.9
69
43
9102
FHL
Trepanation or removal of the local bone process
41.8
79.2
48
12
M81.9
ICD-10 Finland
Osteoporosis, unspecified
9.7
56.2
67
73
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
9.4
53.3
65
73
M85.5
ICD-10 Finland
Aneurysmal bone cyst
+∞
52.5
50
*
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
20.7
52.3
40
20
M85.3
ICD-10 Finland
Osteitis condensans
466.8
45.6
45
*
7332X
ICD-9 Finland
Other disorders of bone and cartilage, Cyst of bone[CYSTA OSSIS ALIA]
+∞
37.7
36
*
M05BA04
ATC
alendronic acid; oral
4.1
37.7
109
285
7332A
ICD-9 Finland
Other disorders of bone and cartilage, Cyst of bone[CYSTA SOLITARIA OSSIS]
+∞
34.6
33
*
N02AX02
ATC
tramadol; systemic, rectal
2.2
33.9
502
3077
M25.5
ICD-10 Finland
Pain in joint
2.1
28.0
438
2689
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
33.8
27.9
36
11
M05BA07
ATC
risedronic acid; oral
6.7
27.9
45
70
N03AX12
ATC
[U] gabapentin; oral
2.5
27.7
207
939
M54.5
ICD-10 Finland
Low back pain
2.0
25.9
458
2918
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
10.6
25.4
28
27
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
27.0
25.0
34
13
N03AX16
ATC
[U] pregabalin
2.2
24.9
271
1440
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.7
24.6
151
621
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.4
24.3
94
298
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
6.6
24.0
39
61
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.8
24.0
134
525
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
21.6
350
2135
M05BX04
ATC
denosumab; parenteral
3.8
20.7
66
184
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
20.0
386
2481
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.5
19.6
136
591
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
19.5
485
3362
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
19.1
330
2040
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
5.4
18.8
37
70
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
+∞
18.8
18
*
NDK99
NOMESCO Finland
Other operation on bone of hand or wrist
39.1
18.6
23
6
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
4.6
18.6
44
98
N02AJ06
ATC
codeine and paracetamol; systemic
1.8
18.3
488
3434
M79.6
ICD-10 Finland
Pain in limb
1.8
18.1
499
3541
M01AH05
ATC
etoricoxib; oral
1.8
17.5
695
5454
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
17.4
261
1533
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
3.2
17.2
69
224
L04AX03
ATC
methotrexate; systemic
2.4
16.9
126
565
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
5.8
16.9
31
55
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
16.8
419
2871
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.3
16.8
134
619
NFK10
NOMESCO Finland
Fenestration or partial or total excision of bone of femur
+∞
16.7
16
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.3
16.4
134
626
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
5.9
16.2
29
50
M01AC06
ATC
meloxicam; systemic, rectal
1.7
16.1
387
2619
J01MA02
ATC
ciprofloxacin; systemic
1.7
15.8
386
2622
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.5
15.5
53
155
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.8
15.5
276
1706
NF1AA
NOMESCO Finland
Hip X-ray examination
2.6
15.4
93
377
N02BE01
ATC
paracetamol; systemic, rectal
2.3
15.4
956
8431
M54.4
ICD-10 Finland
Lumbago with sciatica
1.9
15.4
223
1289
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
15.4
294
1857
B01AB05
ATC
enoxaparin; parenteral
1.8
15.3
312
2009
318
Kela drug reimbursment
Teriparatide
57.5
14.8
17
*
NGK05
NOMESCO Finland
Partial or total excision of bone of lower leg
57.5
14.8
17
*
M01AB05
ATC
diclofenac; systemic, rectal
1.7
14.6
702
5664
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
5.9
14.5
26
45
M81.8
ICD-10 Finland
Other osteoporosis
19.4
14.3
21
11
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
14.1
106
477
SPAT1153
SPAT
Removal of sutures
1.7
14.0
316
2085
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.0
13.9
171
933
M01AH02
ATC
rofecoxib; oral
2.2
13.9
129
634
H05AA02
ATC
teriparatide; parenteral
54.1
13.8
16
*
L03
ICPC
Low back symptom/complaint
1.7
13.8
336
2263
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.4
13.7
97
425
M80, M85,
ICD-10 Finland
+∞
13.6
13
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.2
13.4
122
595
UJF32
NOMESCO Finland
Coloscopy
1.8
13.3
253
1586
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.6
13.2
76
301
L88
ICPC
Rheumatoid/seropositive arthritis
3.1
13.1
54
178
N02AA05
ATC
oxycodone; systemic
2.0
13.1
166
915
M03BX02
ATC
tizanidine; oral
1.6
13.0
673
5448
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
12.9
223
1358
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
4.8
12.9
29
62
L95
ICPC
Osteoporosis
3.6
12.8
42
120
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
4.6
12.7
30
67
S18
ICPC
Laceration/cut
1.6
12.5
483
3630
M84.0
ICD-10 Finland
Malunion of fracture
131.5
12.5
13
*
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.5
12.1
81
345
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.1
12.1
119
598
J01DB01
ATC
cefalexin; oral
1.8
12.0
883
7740
L17
ICPC
Foot/toe symptom/complaint
1.6
12.0
329
2270
ZXA05
NOMESCO Finland
Left side
1.8
12.0
231
1449
A02BC02
ATC
pantoprazole; systemic
1.6
11.9
691
5691
X58
ICD-10 Finland
Exposure to other specified factors
1.9
11.8
175
1015
N06AX21
ATC
duloxetine; oral
2.0
11.7
139
747
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
30.4
11.7
15
5
M01AH01
ATC
celecoxib; oral
1.9
11.6
175
1020
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.8
11.6
207
1270
M87.0
ICD-10 Finland
Idiopathic aseptic necrosis of bone
+∞
11.5
11
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.0
11.4
136
733
M05BB03
ATC
alendronic acid and colecalciferol; oral
5.2
11.3
23
45
A03FA02
ATC
cisapride; oral, rectal
2.5
11.2
73
307
N02BF01
ATC
gabapentin; oral
2.1
11.2
119
614
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
3.4
11.2
40
121
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
3.1
11.2
46
152
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.3
11.1
88
405
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.4
11.0
74
316
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
3.7
11.0
34
93
P01BA02
ATC
hydroxychloroquine; oral
2.2
10.9
92
434
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.9
10.9
152
862
A02BC03
ATC
lansoprazole; oral
1.7
10.9
277
1867
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
3.8
10.8
32
85
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.3
10.8
82
370
M79.7
ICD-10 Finland
Fibromyalgia
2.9
10.7
49
172
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
10.7
275
1859
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
5.1
10.5
22
44
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
4.9
10.5
23
48
NHR99
NOMESCO Finland
Other operation for tumour of ankle or foot
+∞
10.4
10
*
J01FF01
ATC
clindamycin; systemic
1.6
10.4
272
1845
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
4.0
10.4
29
74
L28
ICPC
Limited function/disability (L)
1.8
10.3
173
1039
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
2.6
10.3
58
228
R51.80
ICD-10 Finland
Headache
1.8
10.2
186
1143
L11
ICPC
Wrist symptom/complaint
2.0
10.1
116
615
J01AA02
ATC
doxycycline; systemic
1.6
10.1
784
6764
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
1.9
10.1
138
777
H02AB06
ATC
prednisolone; systemic
1.5
10.1
470
3632
ZXA00
NOMESCO Finland
Right side
1.7
10.0
242
1606
M03BC01
ATC
orphenadrine (citrate); systemic
1.6
10.0
246
1642
L08
ICPC
Shoulder symptom/complaint
1.7
9.9
239
1585
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.8
9.8
165
990
L20
ICPC
Joint symptom/complaint NOS
2.7
9.8
52
198
A02BC05
ATC
esomeprazole; systemic
1.5
9.8
401
3011
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
9.8
776
6701
SPAT1229
SPAT
Assessment of need for aid
2.4
9.7
67
290
M01AE02
ATC
naproxen; oral, rectal
1.5
9.7
603
4937
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
9.6
201
1284
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
3.0
9.5
41
139
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
9.5
390
2922
R52.9
ICD-10 Finland
Pain, unspecified
2.0
9.5
115
621
M70.6
ICD-10 Finland
Trochanteric bursitis
1.8
9.5
139
801
Q78.1
ICD-10 Finland
Polyostotic fibrous dysplasia
100.9
9.4
10
*
M02AA07
ATC
piroxicam; topical
1.6
9.4
325
2345
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
3.0
9.4
40
135
M85.2
ICD-10 Finland
Hyperostosis of skull
+∞
9.4
9
*
M92.6
ICD-10 Finland
Juvenile osteochondrosis of tarsus
+∞
9.4
9
*
M85.1
ICD-10 Finland
Skeletal fluorosis
+∞
9.4
9
*
L04AA13
ATC
[U] leflunomide
3.4
9.4
33
99
M80
ICD-10 Finland
Osteoporosis with pathological fracture
21.9
9.4
13
6
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
4.6
9.3
22
49
WZC30
NOMESCO Finland
Teaching
1.8
9.2
162
985
A07AA02
ATC
nystatin; oral
2.5
9.2
58
241
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
2.9
9.1
43
154
M01AE01
ATC
ibuprofen; systemic, rectal
2.0
9.1
977
9009
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
9.1
252
1728
D16.1
ICD-10 Finland
Benign neoplasm: Short bones of upper limb
15.7
9.0
14
9
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.9
9.0
42
149
WX320
NOMESCO Finland
Spinalanesthesy
1.6
8.9
237
1608
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
12.7
8.9
15
12
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
2.9
8.8
42
151
L01BA01
ATC
methotrexate; systemic
2.9
8.8
40
140
M16.1
ICD-10 Finland
Other primary coxarthrosis
2.0
8.8
103
550
NDM20
NOMESCO Finland
Excision of synovial ganglion of wrist or hand
3.4
8.8
31
93
JN3AD
NOMESCO Finland
Abdominal CT examination
1.8
8.6
130
756
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.1
8.6
78
380
N06AA09
ATC
amitriptyline; systemic
2.0
8.5
91
471
NDK00
NOMESCO Finland
Excision or incsion of a bone of wrist
27.8
8.5
11
*
M80.5
ICD-10 Finland
Idiopathic osteoporosis with pathological fracture
20.2
8.5
12
6
M84.4
ICD-10 Finland
Pathological fracture, not elsewhere classified
90.8
8.4
9
*
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.8
8.4
140
837
ZXD20
NOMESCO Finland
Day surgery
1.8
8.4
131
768
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
+∞
8.3
8
*
M13.9
ICD-10 Finland
Arthritis, unspecified
2.1
8.3
82
412
ACC51
NOMESCO Finland
Release of median nerve
2.0
8.3
86
440
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
8.3
436
3415
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
8.2
735
6373
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
8.1
144
876
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.3
8.1
62
281
D16.0
ICD-10 Finland
Benign neoplasm: Scapula and long bones of upper limb
33.6
8.1
10
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.4
8.1
55
237
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
2.8
8.0
39
142
S72.0
ICD-10 Finland
Fracture of neck of femur
3.1
8.0
32
104
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
3.8
7.9
24
65
SPAT1301
SPAT
No procedures
1.5
7.9
295
2151
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.0
7.9
22
56
M01AX17
ATC
nimesulide; oral
1.6
7.9
207
1395
NH1AD
NOMESCO Finland
Ankle and foot CT
3.4
7.8
27
80
NF3AA
NOMESCO Finland
Femur X-ray examination
3.4
7.8
27
80
D16.3
ICD-10 Finland
Benign neoplasm: Short bones of lower limb
45.3
7.7
9
*
UJD02
NOMESCO Finland
Gastroscopy
2.4
7.6
51
218
SPAT1263
SPAT
Sampling
1.4
7.6
410
3213
J01EA01
ATC
trimethoprim; systemic
1.5
7.6
245
1731
M84.1
ICD-10 Finland
Nonunion of fracture [pseudarthrosis]
25.2
7.6
10
*
H02AB04
ATC
methylprednisolone; systemic
1.7
7.6
134
815
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
2.1
7.6
67
323
NHA30
NOMESCO Finland
Exploration of joint of ankle or foot, arthroscopic
10.1
7.5
14
14
D07AC01
ATC
betamethasone; topical
1.5
7.5
354
2701
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.7
7.5
148
928
R42
ICD-10 Finland
Dizziness and giddiness
1.6
7.5
211
1446
M47.9
ICD-10 Finland
Spondylosis, unspecified
2.9
7.4
34
120
M81.4
ICD-10 Finland
Drug-induced osteoporosis
80.6
7.4
8
*
M85
ICD-10 Finland
Other disorders of bone density and structure
80.6
7.4
8
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
7.4
257
1844
R01BA52
ATC
pseudoephedrine, combinations; oral
1.5
7.4
284
2082
Z01.2
ICD-10 Finland
Dental examination
1.4
7.3
495
4033
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
7.3
104
593
NFK99
NOMESCO Finland
Other operation on bone of femur
+∞
7.3
7
*
A07EC01
ATC
sulfasalazine; oral, rectal
2.0
7.3
83
440
SPAT1216
SPAT
Assessment of functional ability
1.7
7.3
126
762
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.8
7.2
120
716
M89.0
ICD-10 Finland
Algoneurodystrophy
15.9
7.2
11
7
J02AC01
ATC
fluconazole; systemic
1.4
7.2
406
3199
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
7.2
577
4841
L04AB01
ATC
etanercept; parenteral
3.6
7.2
23
65
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.4
7.2
576
4832
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
7.2
426
3389
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.1
7.1
69
345
R4120
NOMESCO Finland
Occupational therapy
2.1
7.0
69
347
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
7.0
139
873
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
2.7
7.0
35
130
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
2.7
6.9
36
137
R74
ICPC
Upper respiratory infection acute
1.4
6.9
381
2988
J01CA04
ATC
amoxicillin; systemic
1.5
6.9
863
7831
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
6.8
70
357
R52.2
ICD-10 Finland
Other chronic pain
2.4
6.8
45
192
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
6.8
289
2157
9104
FHL
Autogenous bone graft
40.3
6.8
8
*
M93.2
ICD-10 Finland
Osteochondritis dissecans
40.3
6.8
8
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
2.1
6.7
64
318
M54.3
ICD-10 Finland
Sciatica
2.1
6.7
65
325
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
6.7
187
1278
M01AC01
ATC
piroxicam; systemic, rectal
1.7
6.6
111
664
WX212
NOMESCO Finland
Femoral plexus blockade
3.3
6.6
24
74
R4110, ,
SPAT
1.7
6.6
132
831
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
3.9
6.6
19
50
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.8
6.5
89
502
ZZH31
NOMESCO Finland
Bone allograft, small pieces
6.2
6.5
16
26
R60.0
ICD-10 Finland
Localized oedema
1.7
6.5
111
669
WX402
NOMESCO Finland
General anaesthesia
1.5
6.5
221
1576
R01AD09
ATC
mometasone; nasal
1.4
6.5
473
3881
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
6.4
132
835
W19
ICD-10 Finland
Unspecified fall
1.8
6.4
95
548
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.1
6.4
59
289
R25.2
ICD-10 Finland
Cramp and spasm
2.8
6.4
31
113
M02AA10
ATC
ketoprofen; topical
1.6
6.4
144
934
NB1BG
NOMESCO Finland
Shoulder and humerus MRI examination with high intensity magnet
2.8
6.4
30
108
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
6.4
120
743
R5110, ,
SPAT
1.9
6.3
82
454
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
2.5
6.3
38
155
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
6.3
382
3032
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
2.9
6.3
29
103
NK6BN
NOMESCO Finland
Bone dynamic isotope examination
18.1
6.3
9
5
ND1AA
NOMESCO Finland
Wrist X-ray examination
2.0
6.3
70
369
M93.8
ICD-10 Finland
Other specified osteochondropathies
+∞
6.3
6
*
NBK10
NOMESCO Finland
Partial or total excision of bone of shoulder or upper arm, humerus
+∞
6.3
6
*
9105
FHL
Homogeneous or heterogeneous bone graft, e.g., joint graft
+∞
6.3
6
*
M89.9
ICD-10 Finland
Disorder of bone, unspecified
+∞
6.3
6
*
P01AB01
ATC
metronidazole; oral, rectal
1.4
6.2
397
3176
M94.2
ICD-10 Finland
Chondromalacia
26.8
6.2
8
*
M05BA06
ATC
ibandronic acid; systemic
3.7
6.2
19
52
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
6.2
482
3985
M19.2
ICD-10 Finland
Other secondary arthrosis
5.1
6.2
18
36
NH3BG
NOMESCO Finland
MRI of foot
6.3
6.2
15
24
G47.3
ICD-10 Finland
Sleep apnoea
1.5
6.2
217
1555
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
5.4
6.2
17
32
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.9
6.2
81
451
L86
ICPC
Back syndrome with radiating pain
2.0
6.1
62
315
L75
ICPC
Fracture: femur
7.7
6.1
13
17
J01FA10
ATC
azithromycin; systemic
1.4
6.1
603
5178
M01AH03
ATC
valdecoxib; oral
2.1
6.1
55
268
A07EA06
ATC
budesonide; oral, local oral
2.3
6.1
44
196
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.4
6.1
41
177
R03BA05
ATC
fluticasone; inhalant
1.5
6.1
181
1253
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
6.0
173
1186
AA1AD
NOMESCO Finland
CT of head and brain
1.5
6.0
240
1762
M20.1
ICD-10 Finland
Hallux valgus (acquired)
1.8
6.0
83
469
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
39
14
28.85
29.06
2.4
3.0
81.73
80.87
ug/l
0.01
39
14
213
1083
2.21
21.51
5.7
5.6
1.06
1.04
mmol/l
0.35
200
1010
840
6818
2.08
21.26
5.7
4.1
11.46
10.68
mm/h
0.90
804
6402
589
4301
1.82
20.12
8.8
6.5
1.22
1.21
mmol/l
2.15
523
3733
523
3809
1.73
16.93
7.3
6.1
1.22
1.21
mmol/l
1.36
488
3529
302
1875
1.85
16.93
1.5
1.3
25.11
29.50
iu/ml
0.31
91
549
668
5209
1.75
16.88
5.1
4.8
6.43
6.56
mmol/l
1.06
634
4875
832
6973
1.87
15.88
9.6
7.7
75.77
77.27
u/l
0.59
800
6614
281
1736
1.84
15.85
1.5
1.3
12.29
9.87
u/ml
0.23
107
672
519
3839
1.68
15.34
5.4
4.7
36.54
36.45
g/l
0.16
481
3629
128
610
2.25
14.87
2.0
2.6
68.13
67.19
g/l
0.84
117
568
425
3037
1.66
13.95
3.4
3.2
2.35
2.36
mmol/l
0.59
394
2789
502
3769
1.63
13.36
13.1
10.8
1.19
1.18
inr
0.29
421
3119
441
3247
1.61
12.46
3.7
3.3
42.25
67.48
ng/l
0.50
279
2096
225
1387
1.79
12.44
2.9
2.5
112.59
113.93
ug/g
0.03
182
1117
550
4299
1.57
11.84
3.0
2.7
—
—
estimate
—
0
0
662
5407
1.59
11.72
9.3
9.1
4.13
3.97
e9/l
0.99
590
4713
540
4221
1.56
11.50
3.7
2.4
77.47
75.43
nmol/l
1.07
502
3860
1006
9279
2.41
11.00
20.2
15.1
139.79
139.69
mmol/l
0.67
996
9102
585
4686
1.55
10.95
6.4
6.4
10.74
11.02
umol/l
0.15
558
4459
344
2445
1.60
10.93
1.4
1.3
1.70
1.64
u/ml
0.03
106
684
389
2849
1.57
10.86
3.3
2.5
54.70
62.42
u/l
2.03
363
2652
212
1335
1.73
10.75
2.6
2.3
2.40
2.36
g/l
0.52
203
1237
1002
9241
2.33
10.71
19.3
13.3
20.20
22.49
mg/l
1.38
848
7479
156
901
1.86
10.57
2.5
2.0
363.60
381.80
nmol/l
0.53
141
842
1006
9302
2.36
10.53
20.4
15.2
3.95
3.95
mmol/l
0.13
995
9104
363
2641
1.57
10.31
2.3
2.1
146.85
204.17
u/l
1.30
343
2514
112
599
1.97
9.55
3.8
4.0
81.92
81.04
ng/l
0.03
99
538
192
1215
1.71
9.48
2.7
2.4
22.55
23.81
%
0.65
184
1136
480
3776
1.49
9.19
3.9
3.3
0.07
0.02
estimate
0.59
100
845
610
5039
1.49
9.13
4.4
3.5
2.38
0.01
estimate
0.49
126
966
605
4990
1.49
9.12
4.3
3.5
0.00
4.90
estimate
1.07
130
1023
844
7476
1.61
9.08
5.3
4.4
14.75
14.63
pmol/l
0.74
787
6960
214
1431
1.62
8.48
2.7
2.4
13.55
13.84
umol/l
0.25
208
1333
195
1281
1.64
8.28
2.0
1.7
1054.61
1182.52
nmol/l
1.46
150
989
71
340
2.17
8.15
6.2
6.3
1.55
1.54
%
0.03
71
318
307
2250
1.51
8.07
2.7
2.6
322.17
332.73
umol/l
1.19
269
2019
316
2330
1.51
8.07
2.6
2.2
2.69
2.78
mg/l
0.35
268
2007
594
4952
1.45
8.02
4.3
3.5
0.00
0.00
estimate
0.50
128
1021
1034
9810
2.61
7.87
23.4
16.9
74.00
73.90
umol/l
0.04
1026
9713
297
2190
1.49
7.49
4.2
3.6
1.02
1.71
kg/l
0.50
212
1452
64
306
2.16
7.39
1.5
1.3
10.82
8.76
u/ml
—
10
44
41
161
2.61
7.33
4.0
2.7
8.34
7.72
pmol/l
0.18
41
161
111
646
1.80
7.29
2.3
2.5
13.81
22.32
au/ml
1.15
13
76
10
5
20.17
7.14
2.6
2.2
—
—
—
0
0
63
305
2.13
7.06
1.4
1.2
3.30
2.65
u/ml
—
7
27
942
8710
1.68
7.05
6.6
5.3
1.74
1.85
mu/l
2.83
885
8189
124
762
1.71
6.75
2.6
2.6
10.33
10.82
g/l
0.77
117
699
66
335
2.03
6.55
1.4
1.5
0.00
0.06
iu/ml
—
9
54
78
429
1.88
6.15
2.4
1.7
4.17
6.62
iu/ml
0.59
19
92
23
73
3.20
6.04
1.3
1.1
120.13
116.38
pmol/l
0.12
23
73
950
8871
1.63
5.99
16.8
12.7
85.89
85.66
ml/min/173m2
0.12
882
8115
137
892
1.61
5.97
5.4
4.8
239.36
252.57
u/l
0.35
122
848
281
2130
1.43
5.96
2.7
1.8
0.82
1.13
mg/l
2.51
212
1633
353
2790
1.40
5.88
3.7
2.9
0.29
0.02
estimate
0.60
106
821
26
91
2.90
5.81
1.6
1.6
33.61
62.83
%
4.11
18
60
202
1447
1.49
5.73
3.7
3.3
0.81
0.82
mmol/l
0.72
185
1380
131
859
1.60
5.54
6.6
9.0
0.71
0.91
mmol/l
0.27
106
716
46
218
2.16
5.49
2.7
3.9
32.17
69.83
mg/l
0.78
36
189
313
2449
1.39
5.47
1.8
1.6
21.49
20.40
nmol/l
0.66
281
2086
1053
10200
3.04
5.41
28.2
20.6
6.73
6.64
e9/l
0.65
1036
10000
463
3864
1.35
5.37
2.4
2.0
98.47
96.54
pmol/l
0.39
268
2033
35
150
2.38
5.29
7.4
10.6
12.00
11.12
mmol/l
0.92
35
134
35
151
2.36
5.21
7.4
10.6
104.89
105.07
mmol/l
0.07
35
135
51
257
2.03
5.21
1.4
1.2
72.33
42.13
u/ml
—
6
23
45
218
2.11
5.10
2.7
3.9
23.22
41.97
mg/l
1.35
35
190
253
1929
1.41
5.10
3.0
2.4
6.93
6.73
e6/l
0.07
235
1757
114
738
1.61
5.09
7.5
9.8
125.68
121.37
g/l
1.45
114
721
44
213
2.11
5.00
1.8
1.6
—
—
—
0
0
1051
10195
2.74
4.91
28.2
20.6
261.48
254.82
e9/l
2.73
1036
10027
1051
10198
2.72
4.85
28.2
20.6
4.50
4.53
e12/l
1.43
1033
10007
275
2143
1.38
4.85
1.5
1.4
2.25
2.34
g/l
0.51
185
1348
130
878
1.55
4.84
7.0
8.9
5.06
5.11
kpa
0.31
122
849
32
138
2.36
4.79
1.7
1.5
269.16
334.20
mu/l
1.39
25
113
1051
10202
2.70
4.77
28.4
20.7
135.35
136.13
g/l
1.11
1046
10114
45
224
2.05
4.77
1.5
1.4
—
—
—
0
0
52
273
1.95
4.76
1.5
1.4
261.81
293.38
ug/g
0.47
29
166
30
127
2.40
4.68
1.2
1.2
—
—
—
0
0
71
415
1.76
4.65
1.6
1.9
—
—
—
0
0
336
2718
1.34
4.64
4.3
3.5
0.00
0.01
estimate
1.28
119
964
123
832
1.54
4.55
3.7
3.5
5.80
5.81
kpa
0.07
118
804
94
599
1.62
4.49
2.4
1.6
—
—
—
0
0
128
878
1.52
4.45
7.1
8.8
12.91
12.51
kpa
0.39
119
851
1018
9787
1.83
4.42
14.4
11.0
26.06
26.30
u/l
0.19
1002
9547
393
3272
1.32
4.40
3.3
3.2
27.81
31.63
u/l
3.15
381
3106
223
1705
1.39
4.37
2.9
2.6
2.44
2.44
mmol/l
0.05
207
1543
117
794
1.53
4.27
3.7
3.6
1.48
1.90
mmol/l
0.75
97
681
546
4768
1.30
4.24
3.7
3.1
111.73
107.91
ug/l
0.15
502
4503
119
813
1.52
4.22
2.4
2.4
0.22
0.22
g/l
0.28
109
769
98
642
1.58
4.19
4.6
3.1
1.23
1.23
mmol/l
0.05
92
548
54
301
1.84
4.16
1.9
2.1
3.47
3.71
g/l
0.65
49
283
58
331
1.80
4.14
1.7
1.4
9.84
9.47
u/l
0.08
51
266
286
2294
1.34
4.11
3.9
3.0
1095.72
1003.21
ng/l
0.21
232
1925
720
6536
1.31
4.10
3.4
3.3
—
—
—
0
0
12
26
4.66
4.06
1.6
1.0
—
—
—
0
0
340
2805
1.31
3.99
3.8
3.1
31.43
54.09
e6/l
1.25
273
2123
39
198
2.01
3.96
2.2
3.7
1.55
2.31
ratio
0.85
24
111
934
8839
1.45
3.92
5.2
4.7
5.77
5.83
mmol/l
0.84
874
8222
277
2226
1.33
3.90
2.5
2.3
—
—
—
0
0
26
113
2.33
3.87
1.6
1.3
—
—
—
0
0
53
301
1.80
3.86
1.9
2.1
4.13
4.27
g/l
0.61
48
283
53
301
1.80
3.86
1.9
2.1
7.27
7.26
g/l
0.02
48
283
94
623
1.56
3.83
3.9
3.6
4.65
4.62
pmol/l
0.11
84
557
298
2428
1.32
3.80
3.6
2.9
0.28
0.41
e6/l
0.88
232
1757
965
9204
1.49
3.74
5.2
4.8
4.65
4.71
mmol/l
1.19
922
8710
151
1108
1.42
3.73
5.8
7.1
104.81
104.45
mmol/l
0.44
151
1108
974
9311
1.51
3.70
5.7
5.3
2.72
2.78
mmol/l
1.63
922
8777
962
9175
1.48
3.68
5.0
4.7
1.48
1.48
mmol/l
0.08
913
8633
55
321
1.75
3.67
1.7
2.3
1.60
1.41
g/l
0.88
44
285
49
279
1.79
3.56
1.6
1.3
—
—
—
0
0
724
6633
1.28
3.53
3.8
3.2
41.71
43.13
u/l
0.22
687
6309
100
688
1.50
3.45
2.9
2.5
66.12
71.28
ml/min/173m2
0.63
43
295
179
1374
1.36
3.39
2.3
1.8
—
—
—
0
0
51
300
1.74
3.34
2.5
2.0
—
—
—
0
0
49
285
1.75
3.34
1.9
2.2
2.66
2.91
g/l
1.23
44
267
908
8603
1.37
3.32
6.5
5.7
38.02
38.51
mmol/mol
1.08
868
8154
224
1786
1.32
3.29
1.8
1.7
91089545.17
42227047.65
pmol/l
0.43
202
1518
46
264
1.78
3.28
1.9
2.3
0.89
0.89
g/l
0.00
40
238
22
97
2.29
3.21
1.2
1.1
—
—
—
0
0
22
97
2.29
3.21
1.2
1.1
—
—
—
0
0
44
251
1.79
3.21
3.7
2.4
12.40
11.56
mg/l
0.32
44
238
10
25
4.03
3.09
1.2
2.0
9.98
17.66
umol/l
—
10
25
36
196
1.87
3.05
1.8
1.7
—
—
—
0
0
7
12
5.86
3.02
1.1
1.2
—
—
—
0
0
61
392
1.59
2.89
1.4
1.2
2.92
1.23
u/ml
—
5
26
81
555
1.50
2.89
1.1
1.0
—
—
—
0
0
22
102
2.18
2.88
1.2
1.1
—
—
—
0
0
853
8052
1.29
2.88
21.8
17.2
332.79
332.82
g/l
0.04
847
8011
31
164
1.92
2.87
1.9
1.6
—
—
—
0
0
23
109
2.13
2.86
7.1
6.3
11.86
11.61
mg/l
0.12
23
102
39
223
1.78
2.85
1.6
1.6
3214.35
12397.10
e6/l
2.16
26
164
14
53
2.66
2.80
1.2
1.1
—
—
—
0
0
12
39
3.10
2.77
1.2
1.1
—
—
—
0
0
270
2253
1.27
2.77
4.8
3.9
94.70
92.83
%
0.61
260
2205
23
111
2.10
2.74
1.1
1.2
—
—
—
0
0
43
257
1.70
2.71
1.6
2.1
9.44
10.58
g/l
1.52
38
238
129
975
1.37
2.70
6.2
5.9
—
—
—
0
0
138
1057
1.35
2.66
4.7
4.6
32.75
31.82
%
0.56
105
720
29
155
1.90
2.63
1.3
1.3
1.50
4.23
u/ml
—
8
52
27
142
1.92
2.57
1.1
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
36
208
1.76
2.56
3.2
3.0
0.34
0.39
iu/ml
0.40
16
110
52
332
1.60
2.56
1.4
1.3
—
—
—
0
0
20
94
2.15
2.56
1.2
1.1
—
—
—
0
0
46
285
1.64
2.55
2.4
1.9
0.47
2.47
ug/l
1.31
37
259
101
741
1.40
2.54
2.7
2.4
11.92
13.02
nmol/l
0.73
93
690
40
239
1.70
2.54
1.4
1.2
—
—
—
0
0
14
56
2.52
2.53
1.4
1.1
—
—
—
0
0
45
278
1.65
2.53
2.1
1.8
—
—
—
0
0
19
91
2.11
2.34
1.2
1.1
—
—
—
0
0
909
8709
1.29
2.33
4.3
4.0
1.28
1.27
mmol/l
0.10
864
8133
200
1646
1.26
2.28
4.4
3.6
410.91
381.32
ng/l
0.04
137
1155
7
18
3.91
2.25
1.3
3.3
9.10
10.86
kpa
—
7
18
7
18
3.91
2.25
1.3
3.3
4.35
5.08
kpa
—
7
18
26
142
1.85
2.24
1.1
1.2
—
215.00
—
0
8
36
219
1.67
2.18
1.2
1.3
186.50
232.86
u/ml
0.63
20
122
7
19
3.70
2.15
1.4
1.1
105.57
99.47
%
—
7
19
22
116
1.92
2.12
1.9
1.3
—
—
—
0
0
22
116
1.92
2.12
1.9
1.3
—
—
—
0
0
10
37
2.72
2.07
1.1
1.2
—
—
—
0
0
22
117
1.90
2.07
1.9
1.3
—
—
—
0
0
45
294
1.55
2.06
1.1
1.1
4.85
4.30
—
8
51
70
503
1.42
2.02
2.6
2.3
1546.63
6353.76
u/l
2.62
28
221
168
1376
1.26
2.00
3.4
2.9
3.47
3.10
e6/l
0.17
91
636
130
1031
1.30
2.00
2.1
2.9
8.04
7.44
umol/l
0.07
115
901
18
91
1.99
1.96
2.2
2.7
32.72
32.57
pg
0.05
18
91
84
627
1.37
1.95
2.4
2.3
6.58
7.45
ug/l
0.24
64
564
27
157
1.74
1.94
1.3
1.3
2.40
5.16
u/ml
—
10
63
36
227
1.61
1.92
2.3
1.5
—
—
—
0
0
22
121
1.84
1.89
1.9
1.3
—
—
—
0
0
179
1487
1.24
1.89
3.3
2.7
1.08
0.95
e6/l
0.18
101
749
14
65
2.17
1.88
1.0
1.1
1.70
1.05
u/l
—
8
32
11
46
2.41
1.85
1.6
1.3
—
—
—
0
0
22
122
1.82
1.85
1.9
1.3
—
—
—
0
0
22
122
1.82
1.85
1.9
1.3
—
—
—
0
0
64
461
1.41
1.84
4.2
3.2
1.15
1.71
mmol/l
0.79
47
341
834
7971
1.21
1.83
22.3
16.6
13.49
13.47
%
0.22
828
7872
9
35
2.58
1.80
1.6
1.5
—
—
—
0
0
11
47
2.35
1.78
1.3
1.8
73.73
112.85
ng/l
1.18
11
47
14
67
2.10
1.76
1.6
2.2
4.43
1.98
u/field
—
7
41
8
30
2.68
1.72
3.9
1.9
40.19
41.68
g/l
—
8
30
7
24
2.93
1.72
1.4
1.2
—
—
—
0
0
54
383
1.43
1.71
1.7
1.7
—
—
—
0
0
172
1441
1.23
1.69
2.1
2.1
—
—
—
0
0
53
376
1.43
1.68
1.6
1.6
8.95
8.27
u/ml
0.10
13
92
19
104
1.84
1.68
1.1
1.1
—
—
—
0
0
12
55
2.20
1.67
1.6
2.3
—
—
—
0
0
6
19
3.17
1.66
1.2
1.2
—
—
—
0
0
79
601
1.34
1.66
1.6
1.4
31.90
25.23
iu/l
0.81
70
515
26
158
1.66
1.63
1.1
1.1
—
—
—
0
0
100
789
1.29
1.63
1.2
1.2
68.48
143.24
u/ml
3.86
38
319
5
14
3.58
1.61
1.2
3.1
1.19
1.21
mmol/l
—
5
14
30
190
1.60
1.61
4.4
5.7
516.57
366.65
iu/ml
—
7
20
90
706
1.30
1.54
9.5
7.0
8.76
8.92
mmol/l
0.09
84
680
152
1272
1.23
1.52
4.9
2.1
29.48
29.16
s
0.27
146
1237
5
16
3.13
1.44
1.6
1.2
—
—
—
0
0
124
1023
1.24
1.42
2.2
1.8
—
—
—
0
0
10
46
2.18
1.40
1.7
1.3
—
—
—
0
0
18
104
1.74
1.37
1.2
1.3
—
—
—
0
0
35
240
1.47
1.36
3.2
2.8
—
—
—
0
0
150
1270
1.21
1.35
1.9
1.8
1.42
1.44
%
0.11
132
1138
14
75
1.88
1.34
1.4
1.6
12.80
11.56
umol/l
0.17
14
70
10
47
2.14
1.34
1.1
1.1
105.48
173.81
iu/ml
—
10
47
33
225
1.48
1.32
1.6
2.1
0.00
0.00
g/l
-0.00
26
202
15
83
1.82
1.31
1.4
1.2
—
—
—
0
0
15
84
1.80
1.27
1.4
1.2
—
—
—
0
0
23
147
1.58
1.23
1.2
1.3
—
—
—
0
0
23
147
1.58
1.23
1.2
1.3
—
—
—
0
0
10
49
2.05
1.22
2.3
3.1
942.90
713.63
u/ml
—
10
49
181
1580
1.18
1.18
2.2
2.2
—
—
—
0
0
114
954
1.22
1.17
2.4
2.1
—
—
—
0
0
10
50
2.01
1.16
1.5
1.5
2.00
1.70
u/field
—
5
39
85
690
1.25
1.16
1.5
1.5
—
—
—
0
0
8
39
2.06
1.15
1.9
1.2
—
—
—
0
0
8
39
2.06
1.15
1.9
1.2
—
—
—
0
0
16
95
1.69
1.14
6.5
4.8
53.63
53.32
u/ml
—
6
31
0
36
0.00
1.14
0.0
4.0
—
1.31
—
0
36
41
302
1.37
1.12
2.8
2.0
5.31
23.26
iu/l
0.46
18
123
8
40
2.01
1.12
2.8
2.8
24.91
215.01
ug/l
—
8
35
337
3090
1.13
1.11
4.2
3.4
7.43
7.89
mmol/l
1.10
304
2664
116
979
1.21
1.11
2.2
1.8
—
—
—
0
0
16
96
1.68
1.10
2.1
2.2
20.67
21.62
mg/l
—
6
44
95
787
1.23
1.09
3.2
4.6
7.64
14.41
ug/l
0.57
77
635
105
1246
0.83
1.09
1.8
1.9
3.37
3.52
ratio
0.44
80
968
8
41
1.96
1.09
3.3
1.7
—
—
—
0
0
8
41
1.96
1.09
3.3
1.7
—
—
—
0
0
8
41
1.96
1.09
3.3
1.7
—
—
—
0
0
8
41
1.96
1.09
3.1
1.7
—
—
—
0
0
53
678
0.77
1.07
1.5
1.6
842.02
981.28
mu/l
0.95
46
572
238
2143
1.14
1.03
1.7
1.6
—
—
—
0
0
41
307
1.35
1.03
5.6
2.3
99.42
93.78
%
1.22
36
298
7
34
2.07
1.03
2.4
2.2
—
—
—
0
0
77
936
0.81
1.02
1.6
1.7
3.42
3.52
mmol/l
0.31
58
664
33
240
1.39
0.99
2.4
1.5
—
—
—
0
0
103
870
1.20
0.99
2.9
2.4
40.91
95.89
u/l
0.49
91
729
48
371
1.31
0.99
1.3
1.4
—
—
—
0
0
22
319
0.68
0.98
1.3
1.6
—
—
—
0
0
5
23
2.18
0.98
1.2
1.3
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
7
36
1.95
0.97
1.0
1.1
104.57
114.14
%
—
7
36
60
481
1.26
0.94
1.8
1.7
—
—
—
0
0
231
2093
1.13
0.92
5.7
5.0
2.11
2.38
ug/l
0.24
213
1912
6
28
2.15
0.91
3.8
1.8
—
—
—
0
0
6
28
2.15
0.91
3.8
1.8
—
—
—
0
0
27
371
0.72
0.91
1.5
1.5
1.38
0.96
ratio
0.82
18
234
27
371
0.72
0.91
1.5
1.5
1.01
1.15
ratio
0.54
18
234
27
371
0.72
0.91
1.5
1.5
0.90
1.19
ratio
1.42
18
234
6
29
2.07
0.89
4.2
1.8
—
—
—
0
0
6
30
2.01
0.87
1.8
2.6
0.64
0.61
mmol/l
—
6
30
14
88
1.60
0.84
2.7
1.7
—
—
—
0
0
27
364
0.74
0.82
1.5
1.5
—
—
—
0
0
26
189
1.39
0.81
1.8
1.7
—
—
—
0
0
15
98
1.54
0.78
2.6
1.7
—
—
—
0
0
5
96
0.52
0.78
2.0
2.0
—
—
—
0
0
93
800
1.18
0.77
2.2
2.0
—
—
—
0
0
29
218
1.34
0.75
1.4
1.4
5.21
9.42
e6/l
0.39
24
159
59
487
1.22
0.75
1.6
1.7
0.30
0.31
mg/l
0.07
27
227
5
24
2.09
0.74
1.2
1.2
—
—
—
0
0
17
116
1.47
0.74
1.3
1.4
—
—
—
0
0
32
245
1.32
0.74
1.3
1.4
64.71
221.88
pmol/l
1.51
32
238
15
217
0.69
0.71
1.1
1.1
1.12
1.67
u/ml
—
7
110
21
152
1.39
0.69
2.3
1.6
—
—
—
0
0
17
239
0.71
0.69
1.3
1.6
76.43
55.73
ug/l
0.91
17
239
13
85
1.54
0.69
2.7
3.5
18.00
69.61
u/ml
1.51
13
85
12
77
1.56
0.68
2.4
2.3
—
—
—
0
0
22
161
1.37
0.68
1.2
1.0
3.47
2.14
eliau/ml
—
9
73
5
27
1.86
0.68
1.4
1.1
78.80
31.33
%
—
5
15
31
395
0.78
0.67
1.6
1.6
104.75
60.99
ug/l
0.47
26
334
7
43
1.63
0.67
2.0
1.8
1.56
1.78
nmol/l
—
7
35
19
260
0.73
0.66
1.1
1.1
1.38
2.91
u/ml
—
10
142
419
3981
1.09
0.66
2.0
1.9
1.33
1.36
mmol/l
0.32
366
3432
27
206
1.32
0.66
1.3
1.1
16.06
14.63
au/ml
0.06
11
68
10
62
1.62
0.65
1.2
1.0
1766.30
1675.61
miu/ml
—
10
62
11
71
1.56
0.62
1.0
1.1
—
—
—
0
0
12
80
1.51
0.60
2.6
1.5
—
—
—
0
0
12
80
1.51
0.60
2.6
1.6
—
—
—
0
0
12
80
1.51
0.60
2.6
1.5
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
0.55
—
0
17
6
35
1.72
0.57
2.3
2.3
—
—
—
0
0
16
115
1.40
0.56
1.5
1.5
—
—
—
0
0
5
86
0.58
0.56
1.6
1.1
—
—
—
0
0
10
65
1.54
0.55
1.6
1.3
82.70
75.46
umol/l
—
10
65
25
196
1.28
0.53
1.9
1.4
—
—
—
0
0
9
63
1.43
0.52
1.4
1.4
—
—
—
0
0
11
75
1.47
0.50
1.5
2.0
—
—
—
0
0
17
127
1.34
0.49
1.8
1.4
—
—
—
0
0
14
101
1.39
0.49
1.7
1.4
0.16
0.17
nmol/l
—
9
75
23
287
0.80
0.46
1.6
1.8
—
—
—
0
0
93
838
1.12
0.46
3.5
3.0
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
34
402
0.84
0.42
1.6
1.5
—
—
—
0
0
5
33
1.52
0.41
1.4
1.4
9.59
8.51
ug/l
—
5
33
0
15
0.00
0.41
0.0
1.0
—
0.07
—
0
10
0
16
0.00
0.41
0.0
1.0
—
0.03
—
0
11
8
59
1.36
0.41
1.1
1.1
11.50
8.71
mm/h
—
8
59
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
37
432
0.85
0.40
1.6
1.3
274.02
243.91
miu/ml
0.22
18
220
9
66
1.37
0.38
1.7
1.4
—
—
—
0
0
9
67
1.35
0.38
1.0
1.2
—
—
—
0
0
9
68
1.33
0.37
1.1
1.6
—
—
—
0
0
11
147
0.75
0.37
1.1
1.3
—
—
—
0
0
9
70
1.29
0.36
3.4
3.5
—
—
—
0
0
11
81
1.36
0.36
1.1
1.3
1.34
0.50
u/ml
—
6
37
6
43
1.40
0.35
1.0
1.0
—
—
—
0
0
23
190
1.22
0.35
2.6
2.3
79.74
103.39
ug/min
0.21
17
117
6
45
1.34
0.33
1.3
1.3
—
—
—
0
0
191
1811
1.07
0.33
1.5
1.5
—
—
—
0
0
6
46
1.31
0.33
1.3
1.3
—
—
—
0
0
11
83
1.33
0.32
2.5
2.4
1.18
1.19
mmol/l
0.37
11
83
7
53
1.32
0.31
2.9
2.4
0.86
0.85
index
—
7
53
26
221
1.18
0.30
2.3
2.8
2.88
2.47
index
0.13
17
120
7
57
1.23
0.29
1.0
1.4
—
15.73
—
0
11
16
130
1.23
0.29
1.3
1.2
—
—
—
0
0
177
1685
1.06
0.28
4.7
4.2
20.81
21.23
%
0.16
83
744
11
85
1.30
0.28
2.5
2.4
4.04
3.96
mmol/l
0.24
11
85
11
85
1.30
0.28
2.5
2.4
106.36
105.82
mmol/l
0.19
11
85
41
456
0.90
0.25
1.1
1.1
0.91
0.90
g/l
0.05
41
456
47
425
1.11
0.25
1.4
1.4
—
—
—
0
0
288
2787
1.05
0.25
4.7
4.1
7.33
7.48
mg/mmol
0.03
188
1731
40
445
0.89
0.25
1.1
1.1
1.51
1.54
g/l
0.31
40
445
9
75
1.20
0.25
1.4
1.6
—
—
—
0
0
11
87
1.27
0.24
1.2
1.1
—
—
—
0
0
6
82
0.73
0.24
1.0
1.5
—
—
—
0
0
19
162
1.18
0.23
1.3
1.1
—
—
—
0
0
10
79
1.27
0.22
1.0
1.1
274.80
286.42
mg/l
—
10
71
0
11
0.00
0.21
0.0
1.1
—
34.50
—
0
6
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
46
421
1.10
0.21
2.0
1.7
2.52
4.53
mg/l
0.80
37
309
0
12
0.00
0.21
0.0
1.0
—
2.24
—
0
7
0
12
0.00
0.21
0.0
1.1
—
0.08
—
0
12
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
15
176
0.85
0.20
2.5
1.5
—
—
—
0
0
6
50
1.20
0.19
1.3
1.3
—
—
—
0
0
11
131
0.84
0.17
1.0
1.1
—
—
—
0
0
8
70
1.14
0.16
1.1
3.0
389.63
944.13
mg
—
8
70
16
139
1.15
0.16
1.6
1.3
6.72
7.51
mmol/l
0.62
16
119
26
237
1.10
0.14
1.3
1.2
—
—
—
0
0
19
170
1.12
0.13
2.2
1.4
—
—
—
0
0
25
273
0.91
0.13
1.3
1.1
—
—
—
0
0
5
44
1.14
0.10
1.4
2.0
—
—
—
0
0
5
44
1.14
0.10
1.4
2.0
—
—
—
0
0
5
45
1.11
0.10
2.0
1.6
0.60
0.46
e9/l
—
5
45
6
54
1.11
0.09
1.2
1.0
939.17
723.49
ng/l
—
6
37
6
54
1.11
0.09
1.2
1.0
383.00
268.84
ng/l
—
6
37
6
54
1.11
0.09
1.2
1.0
31.67
34.79
ng/l
—
6
35
6
57
1.05
0.08
2.0
1.4
118.73
172.93
pmol/l
—
6
57
5
61
0.82
0.08
1.2
1.4
—
—
—
0
0
18
167
1.08
0.07
1.6
1.4
—
—
—
0
0
125
1274
0.98
0.06
3.3
3.1
0.71
0.75
ug/l
0.15
77
758
46
446
1.03
0.05
1.2
1.5
—
—
—
0
0
26
272
0.95
0.04
1.3
1.1
—
—
—
0
0
15
160
0.94
0.04
1.4
1.4
—
—
—
0
0
15
160
0.94
0.04
1.0
1.0
0.10
0.33
u/ml
—
8
46
56
550
1.02
0.02
1.3
1.3
—
—
—
0
0
10
93
1.08
0.02
1.0
1.0
—
—
—
0
0
40
392
1.02
0.01
1.6
1.5
—
—
—
0
0
11
104
1.06
0.01
1.0
1.1
—
—
—
0
0
20
194
1.03
0.00
1.2
1.3
—
—
—
0
0
11
109
1.01
0.00
1.0
1.1
—
—
—
0
0
13
131
0.99
0.00
1.3
1.8
—
1506.67
—
0
6
16
163
0.98
0.00
2.0
3.6
24.77
25.86
mg/l
—
9
113
19
185
1.03
0.00
1.0
1.1
1.35
5.57
u/ml
1.69
11
88
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
0.00
1.4
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
50
1.00
-0.00
1.2
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
3.40
—
0
8
6
59
1.02
-0.00
1.2
1.7
—
943108.33
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
604.00
—
0
5
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
-0.00
2.5
2.0
—
1215.89
—
0
13
5
50
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.01
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_BONEDENSOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDENSOTH | 1.323 [1.12, 1.56] | < 0.001 |
| Birth year | 0.995 [0.99, 1.01] | 0.332 |
During the follow-up period (1.1.1998 — 31.12.2019), 397 out of 3559 females with M13_BONEDENSOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDENSOTH | 1.259 [1.08, 1.47] | 0.004 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 307 out of 2959 males with M13_BONEDENSOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_BONEDENSOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.162% | 0.24% |
| 5 | 0.766% | 1.641% |
| 10 | 1.882% | 3.791% |
| 15 | 3.928% | 7.102% |
| 20 | 6.893% | 11.974% |
Relationships between endpoints
↥Index endpoint: M13_BONEDENSOTH – Other disorders of bone density and structure
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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