granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).
Other and unspecified granulomatous disorders of skin and subcutaneous tissue
DOID EFO Endpoint Browser PheWeb
L12_GRANULOMASKINNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
151 |
4. Check minimum number of eventsNone |
151 |
5. Include endpointsNone |
151 |
6. Filter based on genotype QC (FinnGen only) |
140 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified granulomatous disorders of skin and subcutaneous tissue
based on the number of shared cases.
Similar with more cases:
- Granulomatous disorders of skin and subcutaneous tissue
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 993 | 626 | 359 |
| Only index persons | 911 | 590 | 321 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 49.54 | 49.28 | 50.25 |
| Only index persons | 49.87 | 49.92 | 49.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 140 | 99 | 41 |
| Unadjusted period prevalence (%) | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | 59.30 | 57.29 | 64.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 143
- Matched controls
- 1430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L92.9
ICD-10 Finland
Granulomatous disorder of skin and subcutaneous tissue, unspecified
+∞
98.7
83
*
L92.8
ICD-10 Finland
Other granulomatous disorders of skin and subcutaneous tissue
+∞
72.1
63
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
9.2
30.5
45
68
L92.0
ICD-10 Finland
Granuloma annulare
230.6
20.1
20
*
D07AD01
ATC
clobetasol; topical
3.3
8.1
38
143
L92.1
ICD-10 Finland
Necrobiosis lipoidica, not elsewhere classified
84.3
7.5
8
*
J04BA02
ATC
dapsone; oral
84.3
7.5
8
*
L98.0
ICD-10 Finland
Pyogenic granuloma
+∞
7.3
7
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.8
7.2
45
199
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
7.0
31
112
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
99
745
2.07
3.89
11.4
9.8
4.05
4.17
e9/l
0.21
82
643
51
313
1.98
3.53
2.7
2.0
2.97
2.78
mg/l
0.16
44
266
10
24
4.40
3.26
1.4
1.3
—
—
—
0
0
85
634
1.84
3.12
11.0
6.6
1.21
1.22
mmol/l
0.53
77
557
7
12
6.07
3.06
1.0
1.0
—
—
—
0
0
5
5
10.29
3.00
6.2
3.4
—
—
—
0
0
5
5
10.29
3.00
6.2
3.4
—
—
—
0
0
10
32
3.28
2.49
4.1
2.1
—
—
—
0
0
9
27
3.49
2.44
1.7
1.4
—
—
—
0
0
28
161
1.92
2.27
10.6
6.8
102.61
104.29
mmol/l
1.20
28
161
23
125
2.00
2.18
6.2
3.2
5.84
5.74
kpa
0.20
23
125
5
10
5.14
2.09
1.0
1.2
—
—
—
0
0
11
44
2.63
2.06
3.1
3.2
—
—
—
0
0
6
15
4.13
2.06
1.2
1.2
—
—
—
0
0
23
129
1.93
2.00
11.5
6.8
11.66
12.10
kpa
0.14
23
124
23
129
1.93
2.00
11.5
6.8
5.27
5.18
kpa
0.20
23
124
15
72
2.21
1.94
5.4
7.5
26.00
24.80
mmol/l
0.71
15
72
76
598
1.58
1.93
3.6
3.1
109.72
95.27
ug/l
0.17
71
554
127
1142
2.00
1.87
6.1
5.6
1.87
1.85
mu/l
0.04
121
1058
7
23
3.15
1.82
1.6
1.2
—
—
—
0
0
7
23
3.15
1.82
1.0
1.3
—
—
—
0
0
95
795
1.58
1.79
2.7
3.3
—
—
—
0
0
21
120
1.88
1.74
1.4
2.1
450.90
384.47
nmol/l
0.69
21
114
5
13
3.94
1.73
1.0
1.5
—
—
—
0
0
40
278
1.61
1.68
1.7
1.6
1.03
1.17
mg/l
0.15
28
234
16
85
1.99
1.62
1.2
1.2
191.62
137.16
u/ml
—
5
36
14
71
2.08
1.60
4.2
3.9
5.10
5.16
kpa
0.13
14
66
8
33
2.51
1.56
1.1
1.2
—
—
—
0
0
14
72
2.05
1.55
5.6
2.5
0.64
0.58
%
0.32
14
72
110
967
1.60
1.54
5.0
4.6
14.80
14.84
pmol/l
0.06
104
876
5
15
3.41
1.53
2.2
2.1
—
—
—
0
0
18
104
1.84
1.45
5.9
2.8
4.25
4.41
kpa
0.15
18
104
5
16
3.20
1.45
2.8
3.1
—
—
—
0
0
6
23
2.68
1.38
1.2
1.7
—
—
—
0
0
5
17
3.01
1.37
2.0
2.9
106.80
107.35
mmol/l
—
5
17
5
17
3.01
1.37
2.0
2.9
1.22
1.18
mmol/l
—
5
17
70
571
1.44
1.35
9.7
5.8
1.20
1.22
mmol/l
0.91
64
533
12
62
2.02
1.32
8.3
3.8
40.47
47.98
%
0.42
12
62
11
55
2.08
1.31
7.8
3.0
25.55
25.05
mmol/l
0.26
11
55
10
48
2.16
1.31
2.2
2.2
—
—
—
0
0
34
243
1.52
1.26
1.7
1.7
468.76
459.50
pmol/l
0.04
25
211
24
158
1.62
1.25
6.4
4.5
250.75
251.07
u/l
0.00
24
151
6
26
2.36
1.20
1.3
1.3
—
—
—
0
0
66
547
1.38
1.10
2.2
2.1
104.65
96.08
pmol/l
0.63
39
279
72
606
1.38
1.09
4.2
2.7
—
—
estimate
—
0
0
131
1230
1.78
1.09
25.5
15.2
27.21
22.98
mg/l
0.69
116
1021
9
46
2.02
1.06
1.9
1.8
—
—
—
0
0
7
34
2.11
1.04
1.1
1.7
—
—
—
0
0
13
77
1.76
0.99
4.2
3.0
25.58
24.39
mmol/l
0.87
13
77
7
37
1.94
0.95
1.7
1.6
—
—
—
0
0
13
78
1.73
0.95
5.2
3.4
300.92
152.51
ng/l
0.79
13
70
6
30
2.04
0.88
1.2
1.7
—
—
—
0
0
13
81
1.67
0.84
2.2
1.3
—
—
—
0
0
46
378
1.32
0.77
4.2
3.1
2273.11
1063.74
ng/l
1.37
40
328
47
389
1.31
0.75
4.6
3.0
0.00
0.00
estimate
-0.00
15
126
12
76
1.63
0.74
1.0
1.0
—
—
—
0
0
7
39
1.83
0.73
1.3
1.3
—
—
—
0
0
7
39
1.83
0.73
1.7
1.6
—
—
—
0
0
5
25
2.04
0.73
2.0
1.7
—
—
—
0
0
9
57
1.62
0.72
2.3
1.9
0.90
6.19
ug/l
—
9
49
45
373
1.30
0.71
1.8
1.7
20.19
21.93
nmol/l
0.31
36
314
49
411
1.29
0.70
5.3
4.0
10.94
10.49
mg/mmol
0.03
33
247
11
69
1.64
0.70
16.9
9.0
87.87
94.80
%
0.97
11
69
79
704
1.27
0.70
5.8
3.6
0.00
0.00
estimate
-0.00
17
154
80
715
1.27
0.69
5.8
3.7
0.00
0.00
estimate
-0.00
19
154
15
103
1.51
0.68
6.6
2.4
0.37
0.19
e6/l
0.30
15
96
5
29
1.75
0.64
1.6
1.2
—
—
—
0
0
29
229
1.33
0.63
3.3
3.2
2.62
0.83
e6/l
0.84
19
116
80
720
1.25
0.63
5.8
3.7
0.00
0.00
estimate
-0.00
19
148
47
547
0.79
0.62
1.9
1.9
1.47
1.34
mmol/l
0.45
39
460
5
30
1.69
0.62
1.2
1.7
—
—
—
0
0
120
1136
1.35
0.61
4.9
4.0
1.42
1.28
mmol/l
1.01
113
1050
17
123
1.43
0.61
3.6
3.1
—
—
—
0
0
28
222
1.32
0.60
2.1
1.8
—
—
—
0
0
6
35
1.74
0.58
1.5
1.3
—
—
—
0
0
6
36
1.70
0.57
2.8
1.5
176.33
181.97
%
—
6
36
8
125
0.62
0.57
1.9
1.9
1.64
1.45
%
—
8
110
55
479
1.24
0.57
5.2
4.0
29.23
27.94
ng/l
0.07
39
333
109
1024
1.27
0.55
30.7
19.8
331.24
332.21
g/l
0.57
109
1024
6
38
1.60
0.55
2.2
1.7
—
—
—
0
0
137
1333
1.66
0.54
35.8
23.2
39.18
40.07
%
0.82
137
1319
137
1333
1.66
0.54
34.5
22.8
90.84
91.09
fl
0.25
137
1319
137
1333
1.66
0.54
34.8
23.0
132.84
134.02
g/l
0.41
137
1319
90
830
1.23
0.53
4.0
3.0
53.57
40.61
u/l
0.76
82
789
133
1286
1.49
0.52
30.6
19.4
80.82
74.37
umol/l
0.81
133
1266
124
1188
1.33
0.50
5.8
4.9
6.21
5.86
mmol/l
1.64
115
1100
7
48
1.48
0.47
1.7
1.3
—
—
—
0
0
29
242
1.25
0.43
1.4
1.3
2.44
9.80
u/ml
1.32
16
89
5
31
1.63
0.43
1.0
1.3
—
—
—
0
0
20
159
1.30
0.43
1.9
2.1
—
—
—
0
0
12
88
1.40
0.41
2.3
2.2
—
—
—
0
0
59
532
1.19
0.41
6.6
3.5
0.00
0.00
estimate
-0.00
18
131
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
30
254
1.23
0.40
1.5
1.4
23.19
30.68
iu/ml
—
9
77
124
1196
1.28
0.39
5.5
4.8
1.41
1.50
mmol/l
1.74
118
1114
119
1143
1.25
0.39
8.4
6.0
41.66
38.82
mmol/mol
2.07
113
1077
18
143
1.30
0.39
1.8
1.9
—
—
—
0
0
6
43
1.41
0.35
1.8
1.6
—
—
—
0
0
16
129
1.27
0.32
17.0
7.3
—
—
—
0
0
124
1206
1.21
0.28
5.6
4.9
4.47
4.66
mmol/l
1.29
118
1131
22
189
1.19
0.26
4.3
4.9
25.14
20.72
%
0.55
13
102
9
74
1.23
0.26
2.1
2.0
—
—
—
0
0
24
209
1.18
0.25
6.0
3.4
2.83
2.69
e6/l
0.04
15
97
35
315
1.15
0.24
4.1
2.2
—
—
—
0
0
121
1179
1.17
0.23
21.0
14.6
79.08
81.71
ml/min/173m2
0.71
115
1098
125
1221
1.19
0.23
6.6
5.6
2.50
2.71
mmol/l
1.86
120
1141
25
281
0.87
0.22
1.3
1.7
—
—
—
0
0
19
164
1.18
0.21
1.9
1.7
—
—
—
0
0
5
42
1.20
0.21
6.0
3.9
1.60
2.32
ratio
—
5
17
11
89
1.26
0.21
2.3
3.2
61.20
60.89
ml/min/173m2
—
5
37
0
12
0.00
0.21
0.0
1.9
—
6.98
—
0
12
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
26
237
1.12
0.15
5.0
5.4
2.14
3.51
ug/l
0.47
26
210
9
82
1.10
0.15
2.1
1.6
—
—
—
0
0
17
152
1.13
0.13
3.2
2.3
8.94
7.05
umol/l
0.24
17
135
35
331
1.08
0.10
1.3
1.3
5.00
1.13
u/ml
—
9
95
5
45
1.12
0.10
1.0
1.2
—
—
—
0
0
5
45
1.12
0.10
6.0
4.3
26.68
25.53
mg/l
—
5
36
5
45
1.12
0.10
6.0
4.3
48.50
44.77
mg/l
—
5
36
7
68
1.03
0.08
1.1
1.2
—
—
—
0
0
40
384
1.06
0.07
4.3
3.3
0.40
0.31
e6/l
0.22
34
276
8
94
0.84
0.07
1.5
1.6
719.38
858.26
mu/l
—
8
77
12
109
1.11
0.06
1.5
1.3
—
—
—
0
0
24
248
0.96
0.02
2.0
1.5
—
—
—
0
0
39
398
0.97
0.02
7.2
3.7
0.00
0.00
estimate
-0.00
16
144
32
314
1.02
0.00
8.1
3.6
1.02
1.02
kg/l
0.40
22
200
13
131
0.99
0.00
2.2
1.9
2.99
3.38
ratio
—
7
110
16
158
1.01
0.00
2.3
1.8
—
—
—
0
0
48
476
1.01
0.00
5.7
3.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
60.71
—
0
7
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
54
0.92
-0.00
1.6
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
61
0.98
-0.00
1.0
2.2
15.70
12.84
nmol/l
—
6
55
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
12.00
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
58
0.86
-0.00
1.8
1.6
39.76
59.63
ug/l
—
5
47
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
9.56
—
0
6
5
54
0.92
-0.00
1.6
1.5
0.95
1.16
ratio
—
5
31
0
9
0.00
-0.00
0.0
1.3
—
27.40
—
0
9
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
54
0.92
-0.00
1.6
1.5
0.77
1.16
ratio
—
5
31
5
54
0.92
-0.00
1.6
1.5
0.87
0.89
ratio
—
5
31
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
6
68
0.88
-0.00
1.5
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_GRANULOMASKINNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_GRANULOMASKINNAS | 1.273 [0.96, 1.7] | 0.099 |
| Birth year | 0.994 [0.99, 1.0] | 0.152 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 568 females with L12_GRANULOMASKINNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_GRANULOMASKINNAS | 1.534 [1.1, 2.13] | 0.011 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 329 males with L12_GRANULOMASKINNAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_GRANULOMASKINNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.155% | 0.299% |
| 5 | 0.743% | 1.711% |
| 10 | 1.917% | 4.362% |
| 15 | 3.524% | 8.553% |
| 20 | 6.092% | 14.414% |
Relationships between endpoints
↥Index endpoint: L12_GRANULOMASKINNAS – Other and unspecified granulomatous disorders of skin and subcutaneous tissue
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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