Granulomatous disorders of skin and subcutaneous tissue

L12_GRANULOMATOUSSKIN

Tuberculosis, Cutaneous: Tuberculosis of the skin. It includes scrofuloderma and tuberculid, but not LUPUS VULGARIS.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L92
  • Cause of death: ICD-10 L92

2 out of 7 registries used, show all original rules.

1136

4. Check minimum number of events

None

1136

5. Include endpoints

1167

6. Filter based on genotype QC (FinnGen only)

1043

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L80-L99
Name in latin
Morbositates granulomatosae cutis et telae subcutaneae

Similar endpoints

List of similar endpoints to Granulomatous disorders of skin and subcutaneous tissue based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6497 4475 1996
Only index persons 6066 4239 1827
Unadjusted period prevalence (%)
Whole population 0.11 0.13 0.06
Only index persons 0.13 0.16 0.07
Median age at first event (years)
Whole population 48.67 49.20 47.60
Only index persons 48.68 49.22 47.42

-FinnGen-

Key figures

All Female Male
Number of individuals 1043 786 257
Unadjusted period prevalence (%) 0.24 0.28 0.12
Median age at first event (years) 51.60 49.24 58.79

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1079
Matched controls
10790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L92.0
ICD-10 Finland
Granuloma annulare
1632.9
307.7
596
8
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
13.0
298.8
339
368
L92.1
ICD-10 Finland
Necrobiosis lipoidica, not elsewhere classified
2499.0
230.7
215
*
L92.3
ICD-10 Finland
Foreign body granuloma of skin and subcutaneous tissue
640.2
118.5
115
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
13.9
103.8
99
78
A10AB01
ATC
insulin (human); parenteral
9.4
102.8
130
155
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
8.1
101.8
147
206
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
10.0
99.7
120
134
A10AB05
ATC
insulin aspart; parenteral
5.9
94.6
190
375
H04AA01
ATC
glucagon; nasal, parenteral
10.8
92.2
104
106
L92.9
ICD-10 Finland
Granulomatous disorder of skin and subcutaneous tissue, unspecified
+∞
89.9
85
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.7
88.9
407
1516
D07AD01
ATC
clobetasol; topical
4.0
87.6
323
1038
A10AE04
ATC
insulin glargine; parenteral
4.8
81.3
211
518
A10AE05
ATC
insulin detemir; parenteral
6.4
79.1
142
250
A10AC01
ATC
insulin (human); parenteral
5.2
78.0
181
404
T89
ICPC
Diabetes insulin dependent
6.7
76.4
129
213
A10AA01, ,
ATC
9.0
74.3
95
114
A10AB04
ATC
insulin lispro; parenteral
7.7
73.6
108
153
D07AC01
ATC
betamethasone; topical
3.1
73.1
548
2687
A10AA02, ,
ATC
8.5
72.5
98
126
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
10.0
68.8
81
87
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
15.9
67.8
59
39
L92.8
ICD-10 Finland
Other granulomatous disorders of skin and subcutaneous tissue
+∞
66.3
63
*
H3603, E103,
ICD-10 Finland
22.8
65.2
48
22
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
17.2
64.6
54
33
XQ848
NOMESCO Finland
Dermatological photography
9.0
63.8
81
96
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
24.7
63.1
45
19
TQW80
NOMESCO Finland
Local dermatologic skincare
10.5
61.9
70
71
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
16.5
57.5
49
31
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
17.5
56.8
47
28
A10AE06
ATC
insulin degludec; parenteral
6.2
55.4
99
172
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
19.8
53.8
42
22
E10
ICD-10 Finland
Type 1 diabetes mellitus
8.7
50.1
65
79
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
18.7
47.5
38
21
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.7
46.8
339
1557
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
17.1
45.5
38
23
H3601, E103,
ICD-10 Finland
16.1
45.3
39
25
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
8.4
45.2
60
75
E0000UV, ,
ATC
2.4
45.0
565
3345
103
Kela drug reimbursment
Diabetes, insulin-treated
2.6
44.8
349
1657
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
14.6
41.8
38
27
H3600, E103,
ICD-10 Finland
11.4
41.8
44
40
CKC12
NOMESCO Finland
Photocoagulation of retina
5.5
41.4
84
164
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.5
40.7
107
260
D07AC13
ATC
mometasone; topical
2.3
37.0
396
2142
H36.00
ICD-10 Finland
Diabetic background retinopathy
10.6
36.2
40
39
SPAT1262
SPAT
Handing over of treatment supplies
2.7
36.0
234
1002
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.6
35.2
261
1191
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.1
33.5
72
148
A10AD01
ATC
insulin (human); parenteral
7.2
32.4
49
71
S97
ICPC
Chronic ulcer skin
4.1
28.3
82
214
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
5.1
26.7
58
120
P01BA02
ATC
hydroxychloroquine; oral
3.0
26.2
127
461
L92.2
ICD-10 Finland
Granuloma faciale [eosinophilic granuloma of skin]
+∞
26.1
25
*
H36.01
ICD-10 Finland
Diabetic maculopathy
8.7
25.9
33
39
J01FF01
ATC
clindamycin; systemic
2.1
25.6
334
1905
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
6.9
24.3
38
57
A10AB06
ATC
insulin glulisine; parenteral
9.3
23.9
29
32
XCK10
NOMESCO Finland
Photography of fundus of eye
2.8
23.9
128
490
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
23.8
149
619
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
6.8
23.5
37
56
S29
ICPC
Skin symptom/complaint other
2.1
23.0
263
1418
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
28.0
22.3
30
11
177
Kela drug reimbursment
Insulin glargine 300 U / ml
5.2
22.0
46
92
J04BA02
ATC
dapsone; oral
33.3
20.2
26
8
J02AC01
ATC
fluconazole; systemic
1.8
20.2
505
3515
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
17.7
20.1
31
18
127
Kela drug reimbursment
Transplant complication
7.4
20.0
29
40
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
5.2
19.4
40
79
E000001, ,
ATC
2.0
19.2
250
1404
D07AB02
ATC
hydrocortisone butyrate; topical
1.9
19.2
358
2268
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.9
19.0
91
327
7094A
ICD-9 Finland
Other disorders of skin and subcutaneous tissue, Foreign body granuloma of skin and subcutaneous tissue
+∞
18.8
18
*
XQ845
NOMESCO Finland
Dermatoscopy
5.8
18.6
34
60
H43.1
ICD-10 Finland
Vitreous haemorrhage
4.9
18.6
41
86
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.0
18.4
260
1500
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
5.1
18.4
39
79
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.5
18.3
125
539
H02AB06
ATC
prednisolone; systemic
1.8
17.9
519
3731
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.6
17.7
59
170
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
6.0
17.5
31
53
N03AX12
ATC
[U] gabapentin; oral
2.1
17.2
193
1024
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.4
17.0
121
531
A10AA03, ,
ATC
7.3
17.0
25
35
A46
ICD-10 Finland
Erysipelas
2.2
16.7
147
708
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.8
16.4
30
53
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.6
16.3
31
57
OAB50, ,
SPAT
2.5
16.1
106
448
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
3.9
16.1
47
123
J01MA02
ATC
ciprofloxacin; systemic
1.7
15.6
394
2694
TK800
NOMESCO Finland
Hemodialysis
6.1
15.6
27
45
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
4.4
15.6
39
91
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
15.5
315
2026
S06
ICPC
Rash localized
2.9
15.3
75
273
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
45.7
15.1
18
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
15.0
484
3527
N02BE01
ATC
paracetamol; systemic, rectal
2.2
14.3
973
8674
T90
ICPC
Diabetes non-insulin dependent
1.8
14.2
245
1493
L84
ICD-10 Finland
Corns and callosities
4.1
14.2
39
98
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.8
14.1
252
1553
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
16.0
14.0
22
14
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
6.3
13.8
23
37
S18
ICPC
Laceration/cut
1.6
13.7
493
3667
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.0
13.5
59
201
C10AA01
ATC
simvastatin; oral
1.7
13.4
366
2536
Z94.0
ICD-10 Finland
Kidney transplant status
10.6
13.3
25
24
ZZA00
NOMESCO Finland
Split skin graft
4.3
13.2
34
81
N02AX02
ATC
tramadol; systemic, rectal
1.6
13.2
435
3158
J01DA01
ATC
[U] cefalexin
1.6
13.2
666
5364
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
13.2
234
1437
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
6.0
13.1
23
39
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
13.2
12.9
22
17
L43.8
ICD-10 Finland
Other lichen planus
5.1
12.9
27
54
L04AA06
ATC
mycophenolic acid; systemic
4.9
12.9
28
58
TQW99
NOMESCO Finland
Other minor procedure on skin
3.0
12.8
58
202
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.6
12.7
77
313
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.9
12.5
175
995
D86.3
ICD-10 Finland
Sarcoidosis of skin
24.6
12.5
17
7
UJF32
NOMESCO Finland
Coloscopy
1.7
12.4
262
1689
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
4.6
12.2
29
65
SPAT1263
SPAT
Sampling
1.6
12.2
448
3322
C10AA05
ATC
atorvastatin; oral
1.6
12.2
395
2843
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.5
12.1
81
345
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.6
12.1
71
284
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
27.0
12.1
16
6
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.6
11.9
39
111
A10BK01
ATC
dapagliflozin; oral
2.3
11.9
90
406
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.2
11.8
31
75
S01
ICPC
Pain/tenderness of skin
2.8
11.7
59
218
C03CA01
ATC
furosemide; systemic
1.7
11.7
255
1655
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.7
11.6
229
1445
NHQ40
NOMESCO Finland
Amputation of toe
11.2
11.6
21
19
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.3
11.5
92
425
L92
ICD-10 Finland
Granulomatous disorders of skin and subcutaneous tissue
121.3
11.4
12
*
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.0
11.4
135
724
M65.3
ICD-10 Finland
Trigger finger
2.6
11.3
65
258
J01AA02
ATC
doxycycline; systemic
1.7
11.2
816
7032
N18.8
ICD-10 Finland
Other chronic renal failure
4.6
11.2
26
57
M25.5
ICD-10 Finland
Pain in joint
1.6
11.2
382
2771
H3602, E103,
ICD-10 Finland
25.3
11.2
15
6
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.1
11.1
110
554
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
11.0
146
815
L98.0
ICD-10 Finland
Pyogenic granuloma
43.8
10.9
13
*
171
Kela drug reimbursment
Degludekinsuliini
12.1
10.9
19
16
A02BC02
ATC
pantoprazole; systemic
1.6
10.8
710
5940
CKC15
NOMESCO Finland
Panretinal photocoagulation
10.7
10.8
20
19
A02BC01
ATC
omeprazole; systemic
1.6
10.7
283
1924
XG410
NOMESCO Finland
Flow-volume spirometry
2.9
10.6
49
173
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
10.6
211
1332
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
10.6
140
781
C10AX09
ATC
ezetimibe; oral
1.8
10.5
167
986
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.0
10.5
119
629
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
10.5
257
1714
SPAT1153
SPAT
Removal of sutures
1.6
10.4
306
2133
E000003, ,
ATC
2.6
10.4
58
227
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
19.0
10.3
15
8
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
10.2
332
2369
N03AX16
ATC
[U] pregabalin
1.7
10.2
236
1549
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.7
10.2
55
211
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.8
10.2
31
84
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
2.6
10.2
57
223
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.0
10.2
115
607
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
10.1
135
754
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
11.4
10.1
18
16
H60.9
ICD-10 Finland
Otitis externa, unspecified
2.1
10.1
94
462
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.4
10.0
72
317
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.8
10.0
163
971
S08
ICPC
Skin colour change
2.5
10.0
64
268
D01AE15
ATC
terbinafine; topical
2.3
9.9
73
325
ZXA10
NOMESCO Finland
Bilateral
1.7
9.9
188
1169
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
2.8
9.9
49
180
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
3.1
9.9
40
131
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
9.9
239
1587
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
13.5
9.7
16
12
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.4
9.7
68
297
D02AE01
ATC
carbamide; topical
2.3
9.6
76
349
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.0
9.6
109
576
Z3231
NOMESCO Finland
Registered nurse
1.6
9.6
272
1877
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.2
9.6
38
123
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
9.5
261
1784
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
9.5
275
1907
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
9.4
79
372
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
9.4
300
2125
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
30.3
9.4
12
*
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
4.3
9.4
24
57
7098B
ICD-9 Finland
Other disorders of skin and subcutaneous tissue, Other specified disorders of skin[NECROBIOSIS LIPOIDICA]
+∞
9.4
9
*
SPAT1255
SPAT
Intravenous administration of medicine
2.3
9.4
68
301
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.8
9.4
157
941
J01FA10
ATC
azithromycin; systemic
1.5
9.4
627
5190
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
3.3
9.2
34
105
L57.0
ICD-10 Finland
Actinic keratosis
2.1
9.2
94
478
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
9.2
193
1232
XCH00
NOMESCO Finland
Eye pressure measurement
2.6
9.2
53
211
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.3
9.2
70
317
D07AB08
ATC
desonide; topical
1.9
9.2
120
666
L60.0
ICD-10 Finland
Ingrowing nail
2.4
9.2
65
285
J01DB01
ATC
cefalexin; oral
1.6
9.1
876
7816
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
4.6
9.1
21
46
L28
ICPC
Limited function/disability (L)
1.7
9.1
182
1148
L04AD02
ATC
tacrolimus; systemic
7.1
9.0
21
30
D02AX
ATC
Other emollients and protectives
3.0
9.0
40
138
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
9.0
120
669
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.6
9.0
52
207
A10BA02
ATC
metformin; oral
1.6
8.9
264
1836
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.8
8.9
128
733
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
8.8
83
409
R01AD08
ATC
fluticasone; nasal
1.5
8.8
309
2231
M04AA01
ATC
allopurinol; systemic
2.0
8.7
101
537
CKD40
NOMESCO Finland
Endophotocoagulation of retina
4.2
8.7
23
56
205
Kela drug reimbursment
Chronic hypertension
1.6
8.7
208
1371
A10AD04
ATC
insulin lispro; parenteral
14.2
8.7
14
10
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
14.2
8.7
14
10
N06AX21
ATC
duloxetine; oral
1.8
8.7
143
852
WXQ10
NOMESCO Finland
Psoralen - Ultraviolet A therapy with systemic sensitivisation
50.4
8.7
10
*
H02AB09
ATC
hydrocortisone; systemic
3.2
8.7
33
104
H01
ICPC
Ear pain/earache
1.8
8.7
147
884
S20
ICPC
Corn/callosity
3.8
8.6
26
70
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
8.6
555
4529
Z96.4
ICD-10 Finland
Presence of endocrine implants
16.4
8.6
13
8
C09AA02
ATC
enalapril; systemic
1.7
8.5
163
1013
R06AE07
ATC
cetirizine; oral
1.5
8.5
477
3783
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.2
8.5
72
340
L91.0
ICD-10 Finland
Hypertrophic scar
10.1
8.5
16
16
ZXC50
NOMESCO Finland
Cryotherapy
3.4
8.5
30
90
L16
ICPC
Ankle symptom/complaint
1.8
8.5
136
803
H03AA01
ATC
levothyroxine sodium; systemic
1.6
8.5
262
1836
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
8.5
432
3365
L17
ICPC
Foot/toe symptom/complaint
1.5
8.4
321
2357
L30.0
ICD-10 Finland
Nummular dermatitis
2.7
8.4
45
173
N03AE01
ATC
clonazepam; systemic
2.3
8.4
63
284
R42
ICD-10 Finland
Dizziness and giddiness
1.6
8.3
235
1613
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
8.3
333
2468
S76
ICPC
Skin infection other
2.4
8.3
59
259
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.9
8.3
111
621
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
14.6
8.2
13
9
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.2
8.2
68
319
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.9
8.2
113
638
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.6
8.2
45
175
WZC30
NOMESCO Finland
Teaching
1.7
8.1
164
1035
L89
ICD-10 Finland
Decubitus ulcer and pressure area
11.8
8.1
14
12
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
17.3
8.1
12
7
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
10.1
8.0
15
15
A02BC05
ATC
esomeprazole; systemic
1.5
8.0
410
3188
M10.9
ICD-10 Finland
Gout, unspecified
2.3
8.0
57
251
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
8.0
392
3022
V03AE01
ATC
polystyrene sulfonate; oral
7.3
8.0
18
25
SPAT1229
SPAT
Assessment of need for aid
2.1
8.0
71
343
TNX30
NOMESCO Finland
Soft bandage, unspecified region
4.3
8.0
20
47
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.7
7.9
139
843
ZXA00
NOMESCO Finland
Right side
1.6
7.9
242
1691
Z49.1
ICD-10 Finland
Extracorporeal dialysis
7.8
7.9
17
22
WX002
NOMESCO Finland
Sedation and analgesia
1.6
7.8
178
1158
D09AB01
ATC
zinc bandage without supplements; topical
4.1
7.8
21
52
ACC51
NOMESCO Finland
Release of median nerve
2.0
7.8
88
464
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.6
7.8
242
1696
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.7
7.8
42
162
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.6
7.8
43
168
C07AB07
ATC
bisoprolol; oral
1.4
7.7
437
3454
A10BG03
ATC
pioglitazone; oral
3.4
7.7
27
81
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.4
7.7
53
230
XF402
NOMESCO Finland
ECG with work load test
1.9
7.7
95
518
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
2.9
7.6
36
129
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.0
7.6
88
468
M79.6
ICD-10 Finland
Pain in limb
1.4
7.6
469
3765
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
7.6
277
2008
M01AE03
ATC
ketoprofen; systemic, rectal
1.5
7.6
349
2651
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
11.9
7.6
13
11
RJ410, ,
NOMESCO Finland
25.2
7.6
10
*
A12AA04
ATC
calcium carbonate; oral
6.2
7.6
19
31
137
Kela drug reimbursment
Uraemia requiring dialysis
8.9
7.6
15
17
A10BJ06
ATC
semaglutide; parenteral
2.2
7.5
61
284
L04AX01
ATC
azathioprine; systemic
2.5
7.5
47
195
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.1
7.5
72
359
A02BC03
ATC
lansoprazole; oral
1.5
7.5
276
2006
L43.9
ICD-10 Finland
Lichen planus, unspecified
3.6
7.4
24
68
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
2.8
7.4
36
131
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
3.3
7.4
27
83
R60.0
ICD-10 Finland
Localized oedema
1.8
7.4
124
742
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
7.4
182
1207
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.0
7.3
76
389
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
3.2
7.3
28
89
N77.1*B37.3
ICD-10 Finland
Candidiasis of vulva and vagina
2.8
7.3
35
127
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.3
7.2
55
249
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
15.9
7.2
11
7
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.6
7.2
174
1148
QXB99, ,
SPAT
3.0
7.2
31
106
N02BF01
ATC
gabapentin; oral
1.8
7.2
115
680
H02AB04
ATC
methylprednisolone; systemic
1.7
7.2
139
867
J01DA09
ATC
[U] cefadroxil
1.5
7.2
265
1924
L93.0
ICD-10 Finland
Discoid lupus erythematosus
30.2
7.2
9
*
QDA99
NOMESCO Finland
Other local destruction of skin of lower limb
20.2
7.1
10
5
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
2.3
7.1
51
225
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
4.1
7.1
19
47
R4180
NOMESCO Finland
Podiatric therapy
6.1
7.1
18
30
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
12.1
7.1
12
10
R01AD09
ATC
mometasone; nasal
1.4
7.0
491
4011
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
3.3
7.0
26
81
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.1
7.0
61
293
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.0
7.0
77
404
M54.5
ICD-10 Finland
Low back pain
1.4
6.9
394
3102
CKC10
NOMESCO Finland
Local photocoagulation of retina
3.7
6.9
21
57
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.8
6.9
101
580
G63.2
ICD-10 Finland
Diabetic polyneuropathy
13.9
6.9
11
8
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.2
6.9
27
87
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.9
6.9
88
485
C08CA01
ATC
amlodipine; oral
1.4
6.9
333
2546
B03XA02
ATC
darbepoetin alfa; parenteral
3.5
6.9
23
67
L01
ICPC
Neck symptom/complaint
1.6
6.9
184
1244
RD210, ,
NOMESCO Finland
3.3
6.9
25
77
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.4
6.9
44
185
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
2.0
6.8
68
343
J05AB01
ATC
aciclovir; systemic
1.5
6.8
232
1652
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
6.8
127
783
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.1
6.8
28
93
A10BJ02
ATC
liraglutide; parenteral
2.7
6.8
35
132
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.5
6.8
224
1586
M01AB05
ATC
diclofenac; systemic, rectal
1.4
6.7
663
5728
XW000
NOMESCO Finland
Bone marrow biopsy
2.5
6.7
40
162
ZXA05
NOMESCO Finland
Left side
1.5
6.7
215
1511
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
6.7
157
1027
B01AB05
ATC
enoxaparin; parenteral
1.5
6.7
295
2213
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
22.7
6.7
9
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
22.7
6.7
9
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.8
6.6
92
520
E000002, ,
ATC
1.7
6.6
114
687
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
6.6
433
3487
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
6.6
422
3385
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.6
6.6
126
1938
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
4.2
6.6
17
41
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
8.8
6.6
13
15
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
10.1
6.5
12
12
M48.0
ICD-10 Finland
Spinal stenosis
1.7
6.5
112
675
N06AA09
ATC
amitriptyline; systemic
1.8
6.5
96
553
J01MA12
ATC
levofloxacin; systemic
1.6
6.5
162
1076
L70.0
ICD-10 Finland
Acne vulgaris
2.6
6.5
36
141
WX720
NOMESCO Finland
Own respiration
2.2
6.5
55
261
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
6.5
538
4504
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
3.7
6.5
20
55
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
2.8
6.5
32
118
R23.3
ICD-10 Finland
Spontaneous ecchymoses
3.0
6.5
28
96
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
6.4
396
3152
B01AA03
ATC
warfarin; systemic
1.7
6.4
131
827
R03BA01
ATC
beclometasone; inhalant
1.7
6.4
136
867
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
6.4
206
1448
P01AB01
ATC
metronidazole; oral, rectal
1.4
6.4
420
3378
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.2
6.4
53
249
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
2.6
6.4
37
148
D01AC02
ATC
miconazole; topical
2.0
6.4
71
373
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
2.2
6.4
52
243
K76.9
ICD-10 Finland
Liver disease, unspecified
3.8
6.4
19
51
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
6.6
6.3
15
23
R06AX22
ATC
ebastine; oral
1.5
6.3
185
1274
A10BK03
ATC
empagliflozin; oral
1.8
6.3
100
589
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
6.3
96
559
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
11.1
6.3
11
10
M01AX01
ATC
nabumetone; oral
2.4
6.3
42
180
M03BX02
ATC
tizanidine; oral
1.4
6.3
643
5563
L88
ICD-10 Finland
Pyoderma gangrenosum
+∞
6.3
6
*
SBA00
NOMESCO Finland
Microbiological examinations
2.8
6.3
30
109
WZC00
NOMESCO Finland
Treatment plan or consultation
1.4
6.2
376
2979
C07AB02
ATC
metoprolol; systemic
1.6
6.2
170
1153
N05CD07
ATC
temazepam; oral
1.7
6.2
102
608
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.6
6.2
130
828
L04AD01
ATC
ciclosporin; systemic
3.4
6.2
21
62
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.7
6.2
114
702
M54.4
ICD-10 Finland
Lumbago with sciatica
1.5
6.1
191
1333
S99
ICPC
Skin disease other
2.9
6.1
28
99
L02
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle
2.2
6.1
48
221
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
6.1
430
3495
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
12.6
6.1
10
8
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.7
6.1
124
784
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.7
6.1
115
713
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
3.6
6.1
19
53
R02
ICPC
Shortness of breath/dyspnoea
1.6
6.0
134
865
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
6.0
90
521
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.6
6.0
145
955

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
236
351
8.33
157.74
1.3
1.2
—
—
—
0
0
99
256
4.16
34.66
2.0
2.3
11.27
11.75
mg/l
0.22
94
239
482
2901
2.20
34.06
6.4
4.1
14.73
8.04
mg/mmol
1.82
325
1744
506
3134
2.16
32.92
5.1
3.3
6.81
7.48
mmol/l
3.41
448
2667
471
2846
2.16
32.56
5.3
3.4
76.20
43.70
mg/l
1.80
323
1759
683
4935
2.05
27.34
7.3
5.8
0.58
0.56
e9/l
1.29
596
4264
683
4948
2.04
26.98
7.3
5.8
0.04
0.04
e9/l
2.73
596
4274
691
5044
2.03
26.50
7.5
5.9
1.89
1.94
e9/l
0.65
617
4470
488
3178
1.98
25.80
7.5
5.7
—
—
—
0
0
695
5110
2.01
25.77
7.7
6.1
0.20
0.18
e9/l
1.53
617
4492
635
4552
1.96
25.02
7.8
6.0
8.72
8.60
%
0.46
605
4272
633
4538
1.96
24.87
7.8
6.0
0.75
0.68
%
2.26
602
4240
631
4551
1.93
23.98
7.7
5.9
2.93
2.79
%
0.99
601
4263
641
4662
1.92
23.58
7.8
5.9
28.41
28.52
%
0.10
614
4429
632
4596
1.91
23.03
7.6
5.8
56.58
56.83
%
0.22
611
4388
266
1447
2.11
22.70
1.5
1.3
484.00
551.01
titre
0.22
60
307
207
1029
2.25
22.12
2.4
1.5
—
—
—
0
0
719
5531
1.90
21.15
9.8
9.1
4.04
4.02
e9/l
0.07
632
4832
616
4617
1.78
18.60
10.7
6.5
1.22
1.22
mmol/l
0.21
552
3983
146
678
2.33
18.13
2.4
2.4
18.62
23.39
au/ml
0.36
11
73
547
4020
1.73
17.17
7.5
4.5
35.65
36.16
g/l
1.39
518
3785
429
2959
1.75
16.79
3.9
2.5
54.85
62.41
u/l
1.65
400
2735
58
175
3.45
16.20
2.8
2.2
161.50
97.74
ug/min
0.58
44
105
386
2608
1.75
16.10
1.6
1.3
1.79
1.80
u/ml
0.00
118
697
855
7206
1.90
16.07
10.1
7.5
79.64
77.18
u/l
1.07
824
6813
529
3909
1.69
15.81
19.8
11.9
1.27
1.19
inr
2.84
448
3220
633
4909
1.70
15.75
6.5
6.1
10.33
10.93
umol/l
0.55
604
4673
207
1163
1.97
15.58
11.9
4.9
1.10
1.05
mmol/l
1.74
198
1073
247
1494
1.85
14.77
3.8
2.3
12.79
13.28
umol/l
0.44
234
1390
679
5419
1.68
14.66
6.7
4.6
7.60
6.52
mmol/l
13.98
647
5061
232
1381
1.87
14.58
3.8
2.3
2.35
2.38
g/l
0.31
217
1274
516
3858
1.65
14.21
2.3
2.0
—
—
—
0
0
587
4550
1.64
13.87
3.4
2.5
77.92
76.95
nmol/l
0.37
550
4147
213
1261
1.86
13.53
3.7
2.3
21.53
22.45
%
0.48
201
1181
141
727
2.08
13.37
6.0
3.6
96.39
77.15
ng/l
1.57
125
644
136
707
2.06
12.60
2.9
2.7
76.32
71.21
e9/l
0.64
103
517
333
2283
1.66
12.52
3.5
2.5
337.50
326.27
umol/l
1.09
303
2021
40
112
3.67
12.52
1.3
1.2
—
—
—
0
0
535
4122
1.59
12.44
9.3
5.9
1.22
1.21
mmol/l
0.12
505
3804
336
2318
1.65
12.29
5.8
3.9
—
—
—
0
0
167
942
1.91
12.24
2.4
2.0
384.90
381.21
nmol/l
0.09
156
882
281
1862
1.69
11.94
1.3
1.3
8.88
12.94
u/ml
0.55
114
702
74
305
2.53
11.87
1.2
1.2
—
—
—
0
0
355
2502
1.62
11.84
2.7
2.2
2.81
2.78
mg/l
0.07
321
2142
88
398
2.32
11.53
1.2
1.2
0.18
1.38
u/ml
—
5
23
384
2775
1.60
11.46
2.4
2.1
167.57
235.10
u/l
0.93
371
2638
528
4106
1.56
11.44
2.4
2.0
101.18
96.63
pmol/l
1.20
301
2120
206
1267
1.77
11.39
2.5
1.9
—
—
—
0
0
321
2232
1.62
11.19
1.7
1.5
2.29
2.28
g/l
0.04
188
1374
292
1993
1.64
10.93
1.5
1.3
17.07
28.68
iu/ml
3.40
91
604
638
5221
1.54
10.67
4.8
3.7
10.50
4.57
estimate
0.23
133
1074
162
944
1.84
10.67
3.1
2.7
1.93
1.82
%
0.59
148
844
642
5267
1.54
10.57
4.9
3.7
0.06
0.01
estimate
0.56
116
1023
189
1164
1.76
10.33
1.7
1.4
—
—
—
0
0
630
5169
1.53
10.20
4.9
3.7
0.00
0.00
estimate
0.50
129
1054
125
686
1.93
9.88
3.3
2.8
67.40
67.45
g/l
0.03
115
631
150
877
1.83
9.74
6.0
3.4
7.38
7.38
ph
0.62
99
482
145
842
1.83
9.62
5.9
3.3
1.63
1.81
mmol/l
0.23
127
712
609
4997
1.50
9.59
4.2
3.1
96.98
94.28
ug/l
0.14
569
4707
433
3320
1.51
9.44
3.6
3.1
30.34
31.26
u/l
0.25
414
3144
87
430
2.11
9.19
1.5
1.8
7.66
7.07
iu/ml
0.08
14
99
875
7802
1.64
9.17
5.8
4.6
14.74
14.61
pmol/l
0.86
824
7232
521
4168
1.48
9.12
4.3
3.3
6.25
6.22
ph
0.21
299
2345
382
2902
1.49
8.49
3.4
2.9
0.00
0.04
—
6
55
332
2451
1.51
8.48
3.4
3.1
1116.11
956.96
ng/l
0.57
289
2052
130
760
1.81
8.42
3.0
2.7
10.76
10.53
g/l
0.27
119
703
394
3023
1.48
8.29
3.8
2.9
—
—
—
0
0
1009
9431
2.08
8.25
24.6
15.6
139.37
139.64
mmol/l
3.43
991
9243
1010
9447
2.08
8.19
24.9
15.8
3.98
3.94
mmol/l
3.85
990
9234
221
1504
1.59
8.10
4.8
3.1
0.81
0.82
mmol/l
0.59
213
1430
368
2797
1.48
8.07
6.8
3.7
7.40
7.40
ph
0.08
281
1991
208
1398
1.60
8.03
2.4
2.4
159.11
108.80
ug/g
0.86
155
1096
100
546
1.92
8.02
5.8
3.6
7.41
7.42
ph
0.48
88
456
209
1412
1.60
7.88
1.9
1.7
1230.29
1196.32
nmol/l
0.20
171
1069
947
8702
1.72
7.86
9.5
5.9
43.90
38.59
mmol/mol
26.15
903
8197
969
8966
1.79
7.79
7.3
5.6
1.92
1.85
mu/l
0.86
923
8412
47
192
2.51
7.75
1.7
1.4
248.34
224.62
u/ml
0.26
29
115
60
274
2.26
7.73
1.4
1.4
293.74
295.28
ug/g
0.02
34
150
310
2293
1.49
7.73
5.1
4.4
—
—
—
0
0
136
827
1.74
7.69
4.7
4.2
0.72
0.92
%
0.45
47
229
422
3325
1.44
7.56
4.1
3.5
36.30
61.91
ng/l
0.59
288
2172
732
6391
1.45
7.35
6.1
4.5
735.91
1488.72
e6/l
0.39
11
95
68
334
2.11
7.33
6.0
6.6
0.85
0.93
%
0.90
68
311
999
9357
1.91
7.33
22.3
13.7
21.16
21.76
mg/l
0.25
880
7599
104
599
1.81
7.07
2.0
1.8
1.40
1.42
g/l
0.03
93
552
144
910
1.67
7.06
1.3
1.2
—
—
—
0
0
102
590
1.80
6.84
3.3
2.9
130.73
171.63
ng/l
0.94
94
540
127
786
1.70
6.73
4.7
4.1
0.80
0.61
%
0.54
41
213
412
3284
1.41
6.71
4.0
3.3
2.35
2.36
mmol/l
0.72
377
3008
91
513
1.85
6.63
1.3
1.2
—
—
—
0
0
127
791
1.69
6.57
4.8
4.3
0.11
0.10
%
0.05
36
192
71
371
1.98
6.50
6.0
6.2
1.59
1.53
%
0.31
71
349
180
1230
1.56
6.39
1.8
1.6
—
—
—
0
0
17
31
5.55
6.31
2.0
1.2
—
—
—
0
0
189
1313
1.53
6.22
3.6
1.9
29.97
29.09
s
1.12
182
1279
128
812
1.65
6.18
4.9
4.5
0.47
0.08
%
0.63
36
181
33
127
2.65
6.18
1.1
1.3
—
83.56
—
0
7
342
2672
1.41
6.13
1.9
1.7
20.64
20.76
nmol/l
0.05
291
2273
18
48
3.80
6.10
2.3
2.2
519.85
495.15
min
0.53
13
33
259
1933
1.45
5.96
1.9
1.7
103226257.82
33880217.46
pmol/l
0.53
217
1647
58
291
2.05
5.95
1.5
1.7
0.24
0.23
g/l
0.26
53
276
486
4043
1.37
5.91
2.3
1.9
1.38
1.32
mmol/l
0.75
417
3478
94
563
1.73
5.62
2.3
2.3
—
—
—
0
0
175
1223
1.51
5.58
3.2
3.2
4.20
4.84
e9/l
0.89
153
1073
65
349
1.92
5.53
2.5
2.0
1.37
1.49
g/l
0.44
58
313
427
3509
1.36
5.50
5.8
3.7
52.37
95.60
e6/l
2.19
299
2384
70
387
1.86
5.46
5.9
3.8
—
—
—
0
0
1032
9892
1.99
5.23
27.5
17.6
77.59
72.14
umol/l
4.59
1022
9782
469
3933
1.34
5.20
5.0
3.6
0.02
0.03
estimate
0.26
117
868
358
2892
1.36
5.05
4.3
3.1
0.01
0.01
estimate
0.16
105
855
506
4304
1.33
5.04
13.8
10.2
0.00
0.00
e9/l
0.55
409
3516
138
938
1.54
4.99
8.1
8.1
1.22
0.94
mmol/l
0.38
116
774
63
347
1.87
4.99
1.6
1.3
—
—
—
0
0
50
255
2.01
4.95
1.2
1.2
52.33
46.20
u/ml
—
8
24
84
510
1.70
4.81
9.7
7.6
24.56
24.52
mmol/l
0.04
84
487
139
955
1.52
4.79
8.6
8.1
7.42
7.42
ph
0.01
83
540
18
57
3.19
4.78
2.4
2.3
731.62
567.61
ml
0.90
13
36
935
8774
1.49
4.75
5.3
4.0
1.36
1.25
mmol/l
3.63
882
8156
1027
9861
1.86
4.68
16.0
11.1
25.98
25.02
u/l
1.09
1006
9595
37
173
2.18
4.61
2.3
1.5
157.58
158.25
au/ml
0.01
12
48
123
830
1.54
4.60
2.2
2.3
0.22
0.22
g/l
0.01
112
772
76
455
1.72
4.58
10.3
10.9
15.09
15.73
%
1.36
76
436
24
92
2.65
4.58
3.7
2.5
1.40
1.35
g/24h
0.04
15
58
85
525
1.67
4.57
5.5
3.3
24.37
24.22
mmol/l
0.16
85
518
713
6421
1.33
4.52
4.4
3.7
—
0.10
—
0
10
35
162
2.20
4.47
3.0
3.0
8.13
7.44
mmol/l
0.51
35
156
154
1097
1.47
4.45
2.7
2.6
6.39
6.65
umol/l
0.07
130
954
117
790
1.54
4.37
9.3
8.8
117.61
120.40
g/l
0.79
117
773
21
77
2.76
4.36
1.2
1.1
—
—
—
0
0
123
840
1.52
4.36
8.4
8.6
95.23
95.59
%
0.24
123
815
524
4544
1.30
4.29
3.5
2.7
—
—
estimate
—
0
0
43
220
1.99
4.26
1.9
1.7
9606.12
14021.56
e6/l
0.39
32
159
28
121
2.35
4.20
4.1
3.2
1.27
1.24
%
0.02
28
111
41
208
2.01
4.16
3.1
2.8
1.45
1.52
mmol/l
0.24
41
201
34
162
2.13
4.07
1.1
1.1
139.70
109.29
iu/ml
—
10
31
946
8951
1.46
4.06
5.7
4.8
6.45
5.82
mmol/l
16.64
879
8297
727
6610
1.31
4.04
3.8
3.1
45.49
41.54
u/l
0.77
688
6266
56
319
1.80
4.03
4.3
3.8
629.72
281.11
mg/l
1.03
29
141
26
111
2.38
4.02
1.3
1.3
—
—
—
0
0
358
2972
1.31
4.00
5.1
3.1
42.36
76.24
e6/l
0.69
280
2244
10
18
5.60
3.98
4.6
2.7
—
—
—
0
0
109
742
1.52
3.93
1.3
1.3
188.16
202.65
u/ml
0.07
101
691
120
834
1.49
3.93
1.3
1.2
122.11
140.59
u/ml
0.31
63
322
203
1558
1.37
3.86
3.4
2.7
0.99
0.96
e6/l
0.04
112
786
37
187
2.01
3.82
2.4
1.5
—
—
—
0
0
217
1686
1.36
3.81
4.4
3.6
483.53
401.04
ng/l
0.10
159
1187
38
194
1.99
3.81
4.0
3.6
—
—
—
0
0
108
740
1.51
3.79
9.5
8.1
—
—
—
0
0
71
441
1.65
3.78
3.9
2.9
1.02
1.02
ratio
0.52
61
407
255
2034
1.33
3.76
4.2
2.4
5.34
7.08
e6/l
1.72
237
1854
370
3106
1.29
3.76
2.8
2.2
—
—
—
0
0
27
121
2.26
3.76
2.6
2.5
29.46
48.21
iu/ml
—
5
8
971
9263
1.48
3.70
6.3
4.8
4.58
4.72
mmol/l
3.93
931
8717
149
1093
1.42
3.69
1.4
1.3
—
—
—
0
0
100
679
1.52
3.66
3.8
3.5
4.52
4.54
pmol/l
0.05
93
612
162
1221
1.38
3.43
1.2
1.3
—
—
—
0
0
365
3090
1.27
3.40
4.0
3.3
—
0.63
—
0
8
979
9380
1.47
3.37
7.1
5.4
2.65
2.76
mmol/l
3.60
922
8804
966
9233
1.44
3.36
6.2
4.7
1.44
1.51
mmol/l
5.37
915
8655
38
204
1.89
3.34
7.0
2.1
1.09
0.90
nmol/l
0.49
32
171
306
2547
1.28
3.25
4.7
3.0
0.24
0.37
e6/l
1.70
225
1840
110
784
1.45
3.20
1.6
1.4
—
—
—
0
0
219
1749
1.32
3.17
4.7
2.6
516.66
522.36
mosm/kgh2o
0.14
194
1543
115
828
1.44
3.17
4.6
3.7
7.36
7.36
ph
0.14
91
585
239
1934
1.30
3.14
1.8
1.7
—
—
—
0
0
103
728
1.46
3.13
6.3
3.4
1.23
1.23
mmol/l
0.34
87
625
278
2296
1.28
3.12
4.9
3.8
1.01
1.02
kg/l
0.56
202
1531
1008
9736
1.54
3.10
19.7
12.5
—
—
—
0
0
24
112
2.17
3.08
1.5
1.7
18.33
25.71
ng/l
1.07
24
112
31
160
1.97
3.07
1.1
1.0
6.16
2.50
eliau/ml
—
8
71
225
1812
1.31
3.06
2.6
2.7
2.45
2.44
mmol/l
0.24
195
1633
33
175
1.91
3.03
7.5
2.7
11.56
7.82
pmol/l
0.79
33
175
184
1444
1.33
3.01
3.9
2.9
3.52
3.37
e6/l
0.06
96
676
14
51
2.77
2.99
1.1
1.2
10.86
8.31
mm/h
0.42
14
51
69
1019
0.66
2.94
1.4
1.3
—
—
—
0
0
342
2917
1.25
2.92
6.8
5.8
—
—
—
0
0
21
95
2.23
2.91
3.2
2.1
10.06
10.68
%
0.33
21
95
270
2241
1.27
2.90
2.5
1.7
1.06
1.14
mg/l
0.24
210
1713
278
2316
1.27
2.89
2.7
2.1
—
—
—
0
0
83
1168
0.69
2.78
2.0
1.9
3.33
3.38
ratio
0.11
55
894
274
2290
1.26
2.77
2.1
2.0
—
—
—
0
0
88
620
1.46
2.74
2.5
2.3
5.46
6.79
ug/l
0.57
81
551
38
220
1.75
2.68
3.1
2.3
129.41
129.54
g/l
0.01
27
176
17
73
2.35
2.66
1.1
1.1
—
—
—
0
0
21
99
2.14
2.66
7.9
5.8
12.80
11.50
mg/l
0.84
21
91
110
813
1.39
2.64
1.4
1.5
—
—
—
0
0
43
260
1.68
2.61
3.3
3.6
26.44
57.15
mg/l
1.29
37
224
43
260
1.68
2.61
3.3
3.6
57.50
69.29
mg/l
0.18
37
225
31
170
1.85
2.61
8.1
10.1
11.71
11.39
mmol/l
0.15
31
155
19
87
2.21
2.58
1.8
2.5
1.21
1.20
mmol/l
0.74
19
87
28
149
1.90
2.58
1.1
1.2
—
—
—
0
0
9
25
3.62
2.57
1.2
1.1
—
—
—
0
0
31
171
1.84
2.56
8.1
10.0
102.94
105.26
mmol/l
1.17
31
156
29
157
1.87
2.54
1.7
1.5
—
—
—
0
0
19
88
2.18
2.52
1.8
2.5
4.07
4.05
mmol/l
0.06
19
88
19
88
2.18
2.52
1.8
2.5
105.68
105.78
mmol/l
0.03
19
88
1046
10233
1.73
2.51
32.5
21.4
263.16
257.22
e9/l
2.07
1039
10047
1046
10234
1.72
2.49
32.4
21.4
90.68
90.74
fl
0.14
1041
10138
11
37
2.99
2.49
1.5
2.5
18.85
236.85
ug/l
0.49
11
32
1046
10236
1.72
2.46
32.4
21.3
30.11
30.20
pg
0.84
1041
10140
1046
10236
1.72
2.46
33.0
21.8
39.80
40.13
%
1.29
1041
10136
1046
10236
1.72
2.46
32.5
21.4
4.44
4.47
e12/l
1.34
1034
10023
167
1332
1.30
2.44
1.3
1.2
—
—
—
0
0
1046
10238
1.71
2.43
32.6
21.5
6.81
6.69
e9/l
1.13
1035
10017
1046
10240
1.70
2.40
32.7
21.6
133.06
134.22
g/l
1.97
1041
10143
38
231
1.67
2.29
3.4
3.4
3.50
4.18
ratio
0.10
22
128
11
40
2.77
2.27
2.0
1.7
109.59
49.87
ug/l
0.62
11
40
78
559
1.43
2.26
1.8
2.2
7830.87
6433.89
u/l
0.15
27
243
61
418
1.49
2.23
1.0
1.1
—
—
—
0
0
275
2356
1.22
2.18
5.2
3.7
95.73
93.41
%
0.79
270
2300
24
129
1.88
2.18
1.5
1.3
—
—
—
0
0
24
129
1.88
2.18
1.5
1.3
—
—
—
0
0
24
129
1.88
2.18
1.5
1.3
—
—
—
0
0
24
129
1.88
2.18
1.5
1.3
—
—
—
0
0
326
2843
1.21
2.16
5.3
3.8
0.00
0.01
estimate
1.34
117
1006
7
19
3.70
2.15
1.0
1.0
—
—
—
0
0
7
19
3.70
2.15
1.3
1.1
—
—
—
0
0
16
75
2.15
2.09
3.7
2.5
—
—
—
0
0
64
892
0.70
2.07
1.9
1.7
3.47
3.43
mmol/l
0.11
37
625
60
418
1.46
2.04
1.2
1.3
157.02
239.63
miu/ml
1.09
26
212
115
895
1.32
2.02
3.1
2.3
31.06
37.31
u/l
1.05
93
745
17
83
2.06
2.02
1.5
1.3
—
—
—
0
0
29
171
1.72
1.98
7.6
3.4
—
—
—
0
0
47
314
1.52
1.96
3.0
2.2
2.97
21.21
iu/l
0.54
24
136
10
39
2.58
1.94
2.9
2.9
—
—
—
0
0
27
157
1.74
1.94
7.3
3.4
2.04
2.59
mmol/l
0.75
22
107
27
159
1.72
1.86
5.2
3.5
3.65
4.22
e9/l
0.94
27
159
18
93
1.95
1.85
1.6
1.1
100.44
110.88
pmol/l
0.57
18
93
13
59
2.22
1.84
2.7
2.2
522.88
565.70
e6/l
—
8
46
20
109
1.85
1.78
2.4
2.1
—
—
—
0
0
16
81
1.99
1.75
2.1
1.3
2344.27
1889.65
e6/l
0.13
11
49
14
68
2.07
1.70
1.6
1.4
—
—
—
0
0
14
68
2.07
1.70
1.5
1.4
95411.25
44112.68
e6/l
—
8
31
22
126
1.76
1.69
2.0
1.6
1.25
1.68
mmol/l
3.25
22
126
59
428
1.40
1.66
2.5
2.3
—
—
—
0
0
13
62
2.11
1.66
1.8
1.3
15.45
6.95
u/l
0.38
13
52
19
105
1.82
1.63
1.9
1.7
32.68
32.18
pg
0.15
19
105
10
42
2.39
1.62
1.8
1.7
—
—
—
0
0
5
14
3.58
1.61
2.2
1.4
—
—
—
0
0
31
199
1.57
1.58
1.4
1.3
—
—
—
0
0
7
26
2.70
1.58
3.1
1.9
0.59
0.63
mmol/l
—
7
26
60
441
1.38
1.57
1.9
1.9
—
—
—
0
0
10
44
2.28
1.55
2.9
2.7
—
—
—
0
0
12
57
2.12
1.55
2.9
1.7
110.01
101.27
ng/l
0.07
12
57
8
33
2.43
1.54
2.4
3.6
—
—
—
0
0
18
101
1.80
1.49
3.0
2.2
—
—
—
0
0
20
116
1.74
1.49
2.5
2.2
—
—
—
0
0
13
65
2.01
1.49
1.1
1.1
—
—
—
0
0
35
235
1.51
1.48
2.4
2.9
2.26
2.05
index
0.07
19
118
10
45
2.23
1.46
1.2
1.3
133.90
145.63
nmol/l
—
10
45
23
365
0.62
1.46
1.4
1.5
—
—
—
0
0
21
125
1.69
1.44
2.0
1.5
—
—
—
0
0
102
1253
0.79
1.42
1.7
1.8
—
—
—
0
0
23
362
0.63
1.42
1.4
1.5
1.17
1.28
mm
0.55
15
254
6
23
2.62
1.37
1.5
1.2
10.26
7.59
mmol/l
—
6
23
5
17
2.95
1.36
1.6
1.2
—
—
—
0
0
106
866
1.25
1.34
3.3
4.5
8.25
25.00
ug/l
0.98
88
713
32
217
1.49
1.32
1.5
1.3
8530.96
889.41
e6/l
0.42
24
167
31
209
1.50
1.31
5.5
3.1
52.62
58.62
%
1.82
31
209
9
43
2.10
1.30
1.2
1.4
155.11
166.29
mmol/24h
—
9
43
28
185
1.53
1.30
2.5
2.5
4.52
6.17
umol/l
0.52
19
138
110
906
1.24
1.30
2.3
2.0
0.05
0.03
estimate
0.16
21
184
26
170
1.54
1.27
1.3
1.1
—
—
—
0
0
26
172
1.52
1.21
1.3
1.1
—
—
—
0
0
33
230
1.45
1.20
3.7
2.6
63.43
59.60
%
0.46
33
222
31
215
1.45
1.17
1.4
1.2
19.96
17.07
e6/l
0.05
23
162
12
65
1.86
1.13
1.0
1.0
—
—
—
0
0
7
30
2.34
1.12
5.1
2.1
37.29
29.23
%
—
7
30
13
73
1.79
1.11
1.5
1.7
—
—
—
0
0
26
374
0.69
1.09
1.5
1.6
—
—
—
0
0
18
112
1.62
1.09
2.3
1.7
1.51
0.91
%
—
10
72
14
81
1.74
1.09
1.7
2.2
—
—
—
0
0
7
32
2.19
1.08
1.3
1.6
60.00
80.59
nmol/24h
—
7
32
97
809
1.22
1.05
3.0
2.4
6.18
6.11
ph
0.37
68
540
66
530
1.26
1.01
2.0
2.4
11.95
12.00
nmol/l
0.02
61
481
15
91
1.66
1.01
2.3
1.2
6.41
6.41
mmol/l
0.00
15
83
15
91
1.66
1.01
1.7
1.2
—
—
—
0
0
13
76
1.72
0.99
1.7
1.4
228516.25
129488.98
e6/l
—
8
54
10
54
1.86
0.96
1.6
1.1
18.90
12.63
u/l
—
10
49
12
70
1.72
0.92
1.3
1.2
—
—
—
0
0
6
28
2.15
0.91
1.5
1.3
—
—
—
0
0
8
42
1.91
0.88
4.1
1.9
—
—
—
0
0
29
391
0.73
0.87
1.1
1.1
1.56
1.57
g/l
0.07
29
391
15
95
1.59
0.87
1.6
1.2
—
—
—
0
0
27
368
0.73
0.87
1.0
1.1
—
0.66
—
0
42
8
43
1.87
0.87
1.1
1.5
—
—
—
0
0
30
402
0.74
0.87
1.1
1.1
0.84
0.88
g/l
0.53
30
402
8
44
1.82
0.86
1.3
3.3
0.63
0.89
index
—
8
44
14
88
1.60
0.84
2.1
2.4
—
—
—
0
0
36
275
1.32
0.83
1.3
1.2
—
—
—
0
0
12
73
1.65
0.81
1.3
2.2
1.33
2.25
u/field
—
6
44
14
89
1.58
0.81
1.5
1.1
—
—
—
0
0
37
475
0.77
0.81
1.4
1.5
55.90
59.77
ug/l
0.22
30
399
31
233
1.34
0.80
1.2
1.3
—
—
—
0
0
36
277
1.31
0.79
6.7
3.8
1.40
1.32
mmol/l
0.22
36
272
6
33
1.82
0.79
1.0
1.1
—
—
—
0
0
6
33
1.82
0.79
3.7
4.3
4.17
8.21
mg/l
—
6
28
6
33
1.82
0.79
1.0
1.1
—
—
—
0
0
6
33
1.82
0.79
1.0
1.1
—
—
—
0
0
14
90
1.56
0.78
1.7
1.2
5.64
6.97
g/l
—
9
73
14
90
1.56
0.78
1.7
1.2
0.36
0.43
g/l
—
9
71
14
90
1.56
0.78
1.7
1.2
3.66
2.95
g/l
—
9
71
22
157
1.41
0.77
1.6
1.2
2.30
3.87
u/ml
—
10
70
10
59
1.70
0.76
1.1
1.1
1212.30
1510.61
miu/ml
—
10
59
14
91
1.55
0.75
1.6
1.7
22.25
59.14
%
—
8
63
826
8053
1.11
0.75
25.9
17.2
13.67
13.51
%
2.62
815
7956
5
25
2.00
0.72
1.0
1.2
—
—
—
0
0
12
76
1.59
0.72
4.8
2.2
45.63
41.24
%
0.54
12
76
7
40
1.75
0.71
1.6
1.8
—
—
—
0
0
5
26
1.93
0.70
2.2
4.3
64.40
51.94
%
—
5
26
21
152
1.39
0.69
1.8
1.7
0.45
0.80
g/l
1.30
14
126
174
1583
1.12
0.67
5.2
5.3
1.87
2.30
ug/l
0.86
160
1424
48
394
1.23
0.66
1.6
1.6
22.27
9.37
u/ml
0.34
12
88
33
259
1.28
0.66
1.8
2.7
—
—
—
0
0
23
171
1.35
0.66
1.2
1.2
—
—
—
0
0
42
513
0.81
0.64
1.1
1.1
—
—
—
0
0
68
791
0.85
0.62
1.4
1.6
890.87
982.98
mu/l
0.46
60
658
11
71
1.55
0.62
2.3
1.5
—
—
—
0
0
24
182
1.33
0.61
1.1
1.7
—
—
—
0
0
55
463
1.20
0.61
2.2
2.1
0.08
0.01
estimate
0.42
13
144
15
105
1.43
0.60
1.5
1.4
—
—
—
0
0
90
793
1.15
0.58
6.0
3.6
—
—
—
0
0
24
184
1.31
0.58
1.4
1.3
24.08
23.01
u/l
0.06
17
153
39
320
1.23
0.56
3.1
3.4
38.67
4154.76
u/ml
0.74
33
277
25
194
1.30
0.56
3.2
3.7
24.38
25.51
mg/l
0.08
18
133
6
39
1.54
0.53
1.3
1.2
—
73.86
%
—
0
7
9
64
1.41
0.51
1.1
1.5
—
—
—
0
0
37
306
1.22
0.51
1.4
1.3
—
—
—
0
0
84
941
0.88
0.49
3.5
3.1
0.75
0.75
ug/l
0.02
59
577
7
45
1.56
0.49
1.3
1.1
914.71
160.16
iu/ml
—
7
45
7
47
1.49
0.47
2.4
3.0
15.06
16.67
%
—
7
47
13
177
0.73
0.47
3.8
3.9
28.35
2118.90
u/ml
0.85
13
168
7
49
1.43
0.46
1.1
1.3
—
—
—
0
0
12
86
1.40
0.44
1.3
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
4756.44
—
0
16
0
16
0.00
0.41
0.0
1.0
—
6.82
—
0
16
80
722
1.12
0.40
1.3
1.2
—
—
—
0
0
7
101
0.69
0.39
2.1
1.5
—
—
—
0
0
5
35
1.43
0.39
18.0
4.3
57.20
78.71
mg/l
—
5
28
9
68
1.33
0.37
1.3
1.6
8.73
11.08
umol/l
—
9
62
10
73
1.37
0.34
1.0
1.1
4.11
2.27
nmol/l
—
5
10
6
45
1.34
0.33
3.5
1.2
149.83
490.18
u/l
—
6
39
11
83
1.33
0.32
1.1
1.2
—
—
—
0
0
288
2993
0.95
0.31
1.6
1.6
—
—
—
0
0
8
110
0.73
0.29
1.3
1.1
—
—
—
0
0
12
95
1.27
0.26
1.2
1.1
—
—
—
0
0
12
95
1.27
0.26
1.0
1.1
—
—
—
0
0
36
320
1.13
0.25
1.1
1.4
11.41
9.65
u/l
0.26
26
257
14
115
1.22
0.23
1.0
1.1
—
—
—
0
0
31
275
1.13
0.23
1.1
1.2
—
—
—
0
0
32
285
1.13
0.23
9.6
8.8
—
—
—
0
0
16
189
0.84
0.22
2.7
4.1
75.24
33.03
u/ml
0.41
16
184
10
79
1.27
0.22
4.7
3.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
8
104
0.77
0.21
1.3
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.6
—
39.86
—
0
14
0
14
0.00
0.20
0.0
1.1
—
59.43
—
0
14
0
14
0.00
0.20
0.0
2.4
—
3.60
—
0
7
0
14
0.00
0.20
0.0
5.3
—
8.50
—
0
14
6
52
1.15
0.19
1.0
1.0
1050.33
733.67
ng/l
—
6
36
6
52
1.15
0.19
1.0
1.0
235.50
309.56
ng/l
—
6
36
23
204
1.13
0.18
2.1
1.8
—
—
—
0
0
19
166
1.15
0.18
1.1
1.0
0.16
0.42
u/ml
—
7
56
7
59
1.19
0.18
1.3
1.3
64.00
71.80
umol/l
—
7
59
7
60
1.17
0.18
1.3
1.2
—
—
—
0
0
381
3886
0.97
0.17
3.8
2.9
—
—
—
0
0
15
129
1.17
0.17
1.5
1.2
—
—
—
0
0
19
168
1.13
0.15
1.2
1.2
—
—
—
0
0
20
224
0.89
0.15
1.5
1.4
0.38
0.41
nmol/l
0.09
13
182
66
624
1.06
0.15
2.0
1.7
—
—
—
0
0
40
371
1.08
0.15
1.9
1.6
—
—
—
0
0
19
213
0.89
0.15
1.1
1.1
—
—
—
0
0
19
213
0.89
0.15
1.1
1.1
—
—
—
0
0
12
137
0.87
0.12
1.3
1.3
0.59
13.51
nmol/l
0.50
12
132
45
426
1.06
0.11
1.4
1.6
0.29
0.32
mg/l
0.14
20
183
44
417
1.06
0.10
2.2
1.8
—
—
—
0
0
5
45
1.11
0.10
1.0
1.4
205.14
166.28
pmol/l
—
5
45
10
114
0.88
0.09
1.2
1.7
7.05
7.63
mmol/l
—
10
109
28
262
1.07
0.09
1.1
1.1
2.41
3.01
u/ml
0.15
16
145
6
54
1.11
0.09
2.5
2.8
6.72
7.75
mmol/l
—
6
54
7
64
1.09
0.08
1.1
1.2
—
—
—
0
0
20
214
0.93
0.07
1.4
1.8
—
—
—
0
0
16
148
1.08
0.06
5.7
6.0
336.78
366.59
umol/l
0.39
16
131
10
90
1.11
0.05
1.0
1.1
—
—
—
0
0
13
120
1.08
0.05
1.3
1.3
—
—
nmol/l
—
0
0
34
329
1.03
0.03
2.1
2.1
—
—
—
0
0
20
191
1.05
0.03
1.1
1.0
3.09
3.94
u/ml
0.14
12
95
145
1438
1.01
0.02
1.6
1.8
—
—
—
0
0
68
670
1.02
0.02
1.4
1.4
27.77
25.52
iu/l
0.22
58
570
47
477
0.98
0.01
1.9
1.6
—
—
—
0
0
18
174
1.04
0.00
1.1
1.1
4.06
6.18
u/ml
—
10
75
47
476
0.99
0.00
2.0
1.6
—
—
—
0
0
22
216
1.02
0.00
1.1
1.1
2.10
1.80
u/ml
0.07
11
112
23
228
1.01
0.00
1.1
1.0
1.37
5.08
u/ml
2.65
13
128
131
1306
1.00
0.00
1.5
1.5
—
—
—
0
0
22
221
1.00
0.00
1.1
1.0
0.28
1.35
u/ml
—
9
99
48
479
1.00
0.00
1.8
1.6
—
—
—
0
0
48
479
1.00
0.00
1.3
1.6
254.95
296.61
mu/l
0.96
41
428
21
207
1.01
0.00
1.1
1.1
22.13
11.94
au/ml
—
7
60
30
303
0.99
0.00
1.5
1.3
—
—
—
0
0
48
483
0.99
0.00
1.9
1.6
—
—
—
0
0
23
235
0.98
0.00
1.1
1.1
—
—
—
0
0
12
115
1.04
0.00
5.6
2.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
96.00
—
0
6
0
6
0.00
0.00
0.0
2.7
—
178.33
—
0
6
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
0.03
—
0
7
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
15.57
—
0
7
44
440
1.00
-0.00
2.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
283.80
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
539.62
—
0
5
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
30.86
—
0
5
0
9
0.00
-0.00
0.0
1.3
—
0.15
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
2.6
2.4
1.20
2.31
ug/l
—
5
45
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_GRANULOMATOUSSKIN and mortality.

Females

Parameter HR [95% CI] p-value
L12_GRANULOMATOUSSKIN 1.145 [1.0, 1.32] 0.059
Birth year 0.999 [0.99, 1.01] 0.746

During the follow-up period (1.1.1998 — 31.12.2019), 354 out of 3770 females with L12_GRANULOMATOUSSKIN died.

Males

Parameter HR [95% CI] p-value
L12_GRANULOMATOUSSKIN 1.461 [1.22, 1.75] < 0.001
Birth year 0.987 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 267 out of 1645 males with L12_GRANULOMATOUSSKIN died.

Mortality risk

Mortality risk for people of age

years, who have L12_GRANULOMATOUSSKIN.

N-year risk Females Males
1 0.143% 0.267%
5 0.787% 1.629%
10 1.85% 4.028%
15 3.655% 7.592%
20 6.152% 13.196%

Relationships between endpoints

Index endpoint: L12_GRANULOMATOUSSKIN – Granulomatous disorders of skin and subcutaneous tissue

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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