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Granuloma annulare

DOID EFO Endpoint Browser PheWeb

L12_GRANUANNU

granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L92.0
  • Hospital discharge: ICD-9 — 7098A
  • Cause of death: ICD-10 — L92.0
  • Cause of death: ICD-9 — 7098A

2 out of 7 registries used, show all original rules.

643

4. Check minimum number of events

None

643

5. Include endpoints

None

643

6. Filter based on genotype QC (FinnGen only)

576

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L92
Name in latin
Granuloma anulare

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3343 2530 797
Only index persons 3180 2436 744
Unadjusted period prevalence (%)
Whole population 0.06 0.07 0.02
Only index persons 0.08 0.09 0.03
Median age at first event (years)
Whole population 50.83 50.97 50.58
Only index persons 51.04 51.08 50.91

-FinnGen-

Key figures

All Female Male
Number of individuals 576 463 113
Unadjusted period prevalence (%) 0.14 0.16 0.05
Median age at first event (years) 54.96 52.93 63.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
600
Matched controls
6000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L92.0
ICD-10 Finland
Granuloma annulare
4503599627370496.0
307.7
596
6
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
18.7
256.9
248
218
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.4
92.2
283
846
D07AC01
ATC
betamethasone; topical
4.3
69.3
355
1501
D07AD01
ATC
clobetasol; topical
4.5
62.7
203
607
XQ848
NOMESCO Finland
Dermatological photography
9.4
42.0
52
60
E0000UV, ,
ATC
2.7
31.9
332
1874
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.1
30.5
69
150
D07AC13
ATC
mometasone; topical
2.7
30.0
242
1193
TQW80
NOMESCO Finland
Local dermatologic skincare
7.9
24.4
34
45
A10AB05
ATC
insulin aspart; parenteral
3.9
21.5
68
191
P01BA02
ATC
hydroxychloroquine; oral
3.3
20.2
84
282
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
28.2
20.2
27
10
S29
ICPC
Skin symptom/complaint other
2.5
19.7
163
788
L92.1
ICD-10 Finland
Necrobiosis lipoidica, not elsewhere classified
+∞
17.8
17
*
A10AE05
ATC
insulin detemir; parenteral
3.9
16.9
51
138
A10AE04
ATC
insulin glargine; parenteral
3.0
16.4
79
289
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.3
16.0
43
107
L92.9
ICD-10 Finland
Granulomatous disorder of skin and subcutaneous tissue, unspecified
+∞
14.6
14
*
XQ845
NOMESCO Finland
Dermatoscopy
6.9
14.1
22
33
D07AB02
ATC
hydrocortisone butyrate; topical
2.0
13.8
210
1271
J04BA02
ATC
dapsone; oral
34.9
13.6
17
5
A10AB01
ATC
insulin (human); parenteral
4.4
13.3
34
81
A10AC01
ATC
insulin (human); parenteral
3.0
13.3
62
222
T89
ICPC
Diabetes insulin dependent
3.7
12.8
41
116
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
12.5
133
702
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.0
12.1
153
861
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
122.3
11.5
12
*
A10AE06
ATC
insulin degludec; parenteral
3.8
11.4
35
96
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
9.2
11.3
23
26
103
Kela drug reimbursment
Diabetes, insulin-treated
2.0
11.3
157
910
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.0
11.1
150
861
H02AB06
ATC
prednisolone; systemic
1.8
10.9
294
2097
H04AA01
ATC
glucagon; nasal, parenteral
4.7
10.8
25
55
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
4.3
10.5
27
65
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.8
9.8
52
200
UJF32
NOMESCO Finland
Coloscopy
1.9
9.4
155
946
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.0
9.4
20
41
L30.0
ICD-10 Finland
Nummular dermatitis
3.7
9.3
30
85
S06
ICPC
Rash localized
2.9
9.1
43
155
L43.8
ICD-10 Finland
Other lichen planus
7.2
9.1
21
30
S08
ICPC
Skin colour change
2.9
8.9
42
151
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
8.1
8.9
19
24
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
3.8
8.8
27
74
J02AC01
ATC
fluconazole; systemic
1.7
8.7
282
2074
J01FF01
ATC
clindamycin; systemic
1.8
8.7
164
1041
N02BE01
ATC
paracetamol; systemic, rectal
2.4
8.6
547
4881
J01MA02
ATC
ciprofloxacin; systemic
1.7
8.5
218
1507
T90
ICPC
Diabetes non-insulin dependent
1.8
8.4
137
829
WXQ10
NOMESCO Finland
Psoralen - Ultraviolet A therapy with systemic sensitivisation
+∞
8.3
8
*
L92.8
ICD-10 Finland
Other granulomatous disorders of skin and subcutaneous tissue
+∞
8.3
8
*
A02BC03
ATC
lansoprazole; oral
1.7
8.3
176
1151
S01
ICPC
Pain/tenderness of skin
3.1
8.3
35
118
N03AX12
ATC
[U] gabapentin; oral
2.0
8.3
107
600
A10AB04
ATC
insulin lispro; parenteral
3.5
8.2
28
83
XW000
NOMESCO Finland
Bone marrow biopsy
3.5
8.0
27
79
D02AE01
ATC
carbamide; topical
2.6
8.0
46
184
M25.5
ICD-10 Finland
Pain in joint
1.7
8.0
228
1614
D07AB08
ATC
desonide; topical
2.1
8.0
75
374
SPAT1263
SPAT
Sampling
1.6
7.9
255
1863
SPAT1262
SPAT
Handing over of treatment supplies
2.0
7.8
98
544
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.8
7.6
140
878
J45
ICD-10 Finland
Asthma
2.1
7.6
73
368
S76
ICPC
Skin infection other
2.7
7.4
38
144
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.7
7.4
23
64
E000001, ,
ATC
1.8
7.4
127
780
J01DA01
ATC
[U] cefalexin
1.6
7.2
371
3009
A02BC01
ATC
omeprazole; systemic
1.7
7.2
163
1081
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
7.2
176
1192
SPAT1153
SPAT
Removal of sutures
1.7
7.1
179
1221
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
10.2
7.1
13
13
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.5
7.0
44
184
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
7.7
6.9
15
20
D10BA01
ATC
isotretinoin; oral
2.4
6.9
48
211
L01
ICPC
Neck symptom/complaint
1.8
6.9
112
676
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.3
6.8
54
251
D01AE15
ATC
terbinafine; topical
2.4
6.8
45
193
M79.6
ICD-10 Finland
Pain in limb
1.6
6.8
276
2109
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
40.5
6.8
8
*
A02BC02
ATC
pantoprazole; systemic
1.6
6.7
399
3321
J01FA10
ATC
azithromycin; systemic
1.6
6.7
364
2969
SPAT1255
SPAT
Intravenous administration of medicine
2.6
6.7
38
152
L60.0
ICD-10 Finland
Ingrowing nail
2.6
6.5
37
148
A10AA02, ,
ATC
3.4
6.5
23
70
R06AE07
ATC
cetirizine; oral
1.6
6.4
273
2099
E10
ICD-10 Finland
Type 1 diabetes mellitus
4.1
6.4
17
42
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
6.4
256
1942
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
6.7
6.4
15
23
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
3.7
6.4
20
56
A02BC05
ATC
esomeprazole; systemic
1.6
6.3
241
1805
H03AA01
ATC
levothyroxine sodium; systemic
1.6
6.3
158
1071
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
6.3
135
879
M54.4
ICD-10 Finland
Lumbago with sciatica
1.7
6.3
124
789
D86.3
ICD-10 Finland
Sarcoidosis of skin
18.2
6.3
9
5
L85.89
ICD-10 Finland
Other specified epidermal thickening
+∞
6.3
6
*
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
27.0
6.2
8
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.8
6.2
97
578
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
6.1
125
803
C10AA05
ATC
atorvastatin; oral
1.6
6.1
219
1616
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
6.1
105
644
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.7
6.0
127
822

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
185
197
13.13
165.31
1.4
1.2
—
—
—
0
0
98
368
2.99
19.51
2.4
2.4
21.43
17.78
au/ml
—
9
38
164
813
2.40
18.66
1.4
1.4
385.56
524.67
titre
0.83
36
180
389
2775
2.14
17.27
6.9
5.9
0.56
0.56
e9/l
0.01
337
2374
390
2785
2.14
17.26
6.9
5.9
0.04
0.04
e9/l
1.90
336
2380
394
2839
2.13
16.84
6.9
5.9
1.86
1.96
e9/l
0.96
345
2500
280
1787
2.06
16.56
6.9
5.7
—
—
—
0
0
396
2878
2.11
16.28
7.0
6.2
0.19
0.19
e9/l
0.43
348
2509
359
2553
2.01
15.21
7.4
5.9
0.79
0.69
%
2.50
341
2377
324
2228
1.99
15.06
2.3
2.1
—
—
—
0
0
360
2568
2.00
15.06
7.4
6.0
8.75
8.59
%
0.41
345
2405
365
2629
1.99
14.69
7.3
5.9
28.70
28.70
%
0.00
350
2490
358
2563
1.98
14.65
7.3
5.9
3.01
2.83
%
0.82
342
2395
358
2596
1.94
13.73
7.1
5.8
56.04
56.88
%
0.75
346
2473
265
1758
1.91
13.14
4.2
3.3
6.71
7.29
mmol/l
1.56
220
1499
408
3121
1.96
13.00
9.3
9.1
3.88
4.01
e9/l
0.63
358
2712
243
1603
1.87
11.98
4.4
3.4
72.26
47.92
mg/l
0.58
145
982
246
1641
1.85
11.62
5.4
4.1
12.42
9.23
mg/mmol
0.40
142
963
487
4098
2.00
10.03
9.4
7.6
78.52
78.06
u/l
0.09
469
3870
57
228
2.66
9.93
1.2
1.2
0.18
2.20
u/ml
—
5
13
344
2616
1.74
9.83
7.9
6.4
1.22
1.22
mmol/l
0.71
304
2259
363
2804
1.75
9.79
6.5
6.1
11.09
10.93
umol/l
0.06
345
2659
172
1085
1.82
9.36
1.3
1.3
5.34
12.26
u/ml
1.33
69
405
216
1471
1.73
8.97
1.5
1.3
1.95
2.22
u/ml
0.09
65
406
56
238
2.49
8.63
1.3
1.7
8.84
5.17
iu/ml
—
8
49
178
1164
1.75
8.45
1.5
1.3
17.62
29.45
iu/ml
2.15
57
368
307
2323
1.66
8.43
2.4
2.0
101.34
97.75
pmol/l
0.54
168
1188
25
68
3.79
8.25
1.2
1.3
—
—
—
0
0
25
69
3.74
8.09
1.1
1.3
—
71.62
—
0
5
238
1703
1.66
8.02
2.9
2.4
54.35
64.54
u/l
1.83
219
1570
297
2258
1.62
7.78
5.7
4.4
35.99
36.14
g/l
0.21
279
2131
292
2226
1.61
7.46
17.5
10.8
1.27
1.17
inr
2.39
245
1832
574
5304
2.90
7.10
21.5
15.7
3.96
3.94
mmol/l
1.19
561
5188
327
2581
1.59
7.08
2.9
2.5
81.45
77.18
nmol/l
1.93
303
2334
302
2341
1.58
7.06
6.9
5.9
1.22
1.22
mmol/l
0.77
282
2154
373
3052
1.59
6.79
5.6
4.4
6.94
6.46
mmol/l
3.14
355
2861
572
5295
2.72
6.69
21.6
15.6
139.47
139.71
mmol/l
1.71
560
5193
555
5072
2.26
6.67
7.3
5.6
1.89
1.85
mu/l
0.38
521
4741
109
665
1.78
6.41
1.8
1.4
—
—
—
0
0
40
168
2.48
6.35
1.1
1.3
—
—
—
0
0
567
5247
2.47
6.28
19.5
13.7
20.33
21.76
mg/l
0.52
497
4270
498
4415
1.75
6.23
5.9
4.6
14.82
14.66
pmol/l
0.79
467
4066
129
834
1.70
6.17
2.8
2.3
13.04
13.50
umol/l
0.25
124
778
587
5538
3.77
6.06
24.6
17.7
74.83
71.73
umol/l
2.02
580
5476
94
566
1.78
5.76
1.9
1.4
—
—
—
0
0
36
151
2.47
5.74
1.2
1.2
63.32
47.49
u/ml
—
5
15
342
2802
1.51
5.74
3.7
3.1
94.97
94.12
ug/l
0.03
322
2617
243
1855
1.52
5.71
3.5
3.0
30.91
31.09
u/l
0.03
229
1752
178
1269
1.57
5.70
5.2
4.7
—
—
—
0
0
196
1436
1.54
5.54
3.5
3.1
1076.06
908.59
ng/l
0.45
171
1207
71
398
1.89
5.47
1.9
3.1
68.08
67.59
g/l
0.27
63
368
107
684
1.69
5.29
2.7
3.2
4.33
5.21
e9/l
0.71
90
600
211
1593
1.50
5.10
4.6
3.8
7.40
7.40
ph
0.28
159
1127
548
5066
1.94
5.09
5.6
4.9
6.21
5.82
mmol/l
5.33
504
4686
101
644
1.68
5.03
6.7
4.9
1.10
1.05
mmol/l
0.88
95
589
534
4901
1.81
5.02
8.0
5.9
41.38
38.57
mmol/mol
6.41
503
4607
86
525
1.74
5.02
2.2
2.0
387.42
376.67
nmol/l
0.23
79
495
583
5527
2.93
5.00
15.3
11.3
25.60
24.54
u/l
0.97
567
5379
116
772
1.62
4.89
2.8
2.3
2.40
2.38
g/l
0.13
111
714
71
414
1.81
4.83
2.5
2.9
10.70
10.46
g/l
0.23
65
387
77
461
1.77
4.80
5.1
4.5
0.88
0.88
%
0.01
26
134
65
375
1.82
4.58
2.5
2.7
75.85
71.53
e9/l
0.34
48
272
173
1278
1.50
4.57
5.6
3.9
—
—
—
0
0
73
442
1.74
4.38
5.2
4.3
0.61
0.63
%
0.03
23
121
592
5730
3.49
4.36
29.7
21.4
4.42
4.45
e12/l
0.91
584
5622
80
498
1.70
4.35
1.3
1.2
—
—
—
0
0
352
2991
1.43
4.34
4.1
3.7
20.54
2.62
estimate
0.41
68
619
172
1282
1.48
4.31
1.6
1.5
2.34
2.29
g/l
0.09
99
783
354
3015
1.42
4.28
4.2
3.7
0.00
0.02
estimate
1.06
59
587
72
439
1.73
4.22
5.3
4.6
0.20
0.08
%
0.50
20
111
592
5731
3.47
4.21
29.7
21.5
6.56
6.66
e9/l
0.55
585
5617
236
1892
1.41
3.93
3.2
3.2
2.37
2.36
mmol/l
0.38
210
1719
346
2960
1.40
3.93
4.1
3.7
0.00
0.00
estimate
0.50
66
608
287
2381
1.39
3.90
3.5
3.3
6.22
6.21
ph
0.07
154
1324
172
1305
1.45
3.88
3.1
2.6
343.40
327.34
umol/l
0.97
151
1162
73
459
1.67
3.83
5.5
4.8
0.89
0.05
%
0.76
19
105
182
1402
1.43
3.77
2.6
2.1
2.82
2.83
mg/l
0.03
164
1197
128
922
1.49
3.75
4.0
3.5
791.38
358.28
ng/l
0.38
90
648
56
331
1.76
3.67
1.9
2.5
—
—
—
0
0
20
79
2.58
3.66
1.1
1.1
154.80
18.00
iu/ml
—
5
15
233
1886
1.38
3.59
4.1
3.5
35.15
67.29
ng/l
0.47
158
1256
114
812
1.50
3.52
3.2
3.1
0.81
0.82
mmol/l
0.20
108
771
216
1734
1.38
3.48
3.2
2.8
—
—
—
0
0
110
784
1.49
3.38
2.4
2.3
119.12
109.04
ug/g
0.15
81
610
91
624
1.54
3.35
1.4
1.3
—
—
—
0
0
198
1575
1.38
3.35
2.6
2.1
140.14
210.13
u/l
0.90
191
1498
77
514
1.57
3.20
2.3
2.7
2.07
1.87
%
0.82
70
459
406
3629
1.37
3.17
4.5
3.7
—
0.00
—
0
6
111
803
1.47
3.17
1.8
1.7
1302.94
1189.46
nmol/l
0.79
87
603
570
5454
1.90
3.04
17.9
12.4
—
—
—
0
0
193
1549
1.36
3.04
1.8
1.6
21.35
20.51
nmol/l
0.34
162
1306
87
610
1.50
2.90
2.3
2.6
7.62
7.21
umol/l
0.06
73
528
49
300
1.69
2.88
1.2
1.2
—
—
—
0
0
34
188
1.86
2.81
5.5
4.8
0.84
0.92
%
0.52
34
175
98
711
1.45
2.75
1.2
1.3
—
—
—
0
0
42
250
1.73
2.73
1.1
1.1
—
—
—
0
0
19
85
2.28
2.73
2.3
2.2
59.56
77.83
ug/min
0.15
14
51
15
60
2.54
2.72
3.4
2.3
—
—
—
0
0
169
1354
1.35
2.65
3.9
3.5
—
0.25
—
0
12
67
454
1.54
2.62
1.6
1.4
—
—
—
0
0
199
1639
1.32
2.57
6.4
6.0
—
—
—
0
0
404
3673
1.31
2.42
3.6
3.1
44.96
42.63
u/l
0.26
380
3466
60
406
1.53
2.38
4.3
3.6
84.54
77.21
ng/l
0.28
52
359
8
22
3.67
2.37
3.0
3.5
—
—
—
0
0
69
485
1.48
2.29
3.3
3.4
7.38
7.38
ph
0.04
48
275
20
101
2.01
2.18
1.3
1.4
268.50
244.04
u/ml
—
8
58
7
19
3.71
2.15
1.3
1.6
139.14
146.32
nmol/l
—
7
19
65
460
1.46
2.10
3.1
3.4
2.25
1.70
mmol/l
0.69
54
386
9
31
2.93
2.08
1.7
1.5
6.90
6.02
ug/l
—
9
26
10
37
2.73
2.08
1.1
1.2
—
—
—
0
0
95
722
1.38
2.07
2.2
1.8
—
—
—
0
0
136
1092
1.32
2.06
2.0
1.7
105310161.32
21520776.86
pmol/l
0.37
113
934
266
2326
1.26
2.05
2.2
1.9
1.33
1.34
mmol/l
0.07
219
1990
33
522
0.61
2.05
1.3
1.3
—
—
—
0
0
8
26
3.10
2.02
3.0
3.2
—
—
—
0
0
520
4945
1.39
2.00
5.0
4.1
1.32
1.25
mmol/l
1.29
479
4564
22
119
1.88
1.99
3.8
2.1
133.53
129.54
g/l
0.18
15
89
281
2480
1.25
1.98
13.5
10.3
0.00
0.00
e9/l
0.49
224
2017
290
2570
1.25
1.97
3.1
2.6
—
—
estimate
—
0
0
40
259
1.58
1.95
2.8
2.3
—
—
—
0
0
10
39
2.59
1.95
1.5
1.3
18.52
7.85
u/l
—
10
33
549
5276
1.48
1.93
6.8
5.5
2.72
2.78
mmol/l
0.79
503
4931
233
2030
1.24
1.80
4.4
3.9
51.08
92.92
e6/l
1.41
149
1376
131
1066
1.29
1.80
2.5
2.6
2.46
2.45
mmol/l
0.47
112
956
22
124
1.80
1.78
1.7
1.7
8746.76
13470.75
e6/l
0.26
17
92
543
5220
1.42
1.78
6.0
4.9
4.65
4.75
mmol/l
1.59
512
4884
33
210
1.60
1.75
6.0
4.5
1.75
1.48
%
1.01
33
198
254
2242
1.23
1.72
4.1
3.6
0.03
0.02
estimate
0.19
58
508
7
24
2.94
1.72
1.1
1.3
144.29
165.99
mmol/24h
—
7
24
26
157
1.69
1.68
1.1
1.4
315.14
306.51
ug/g
0.10
14
93
14
69
2.05
1.65
2.4
1.6
1.24
1.48
mmol/l
1.21
14
69
540
5199
1.39
1.62
5.9
4.8
1.48
1.53
mmol/l
1.82
499
4847
167
1419
1.25
1.60
3.5
3.0
—
0.00
estimate
—
0
7
10
43
2.35
1.59
1.1
1.1
1.23
1.20
nmol/l
—
10
37
65
486
1.38
1.59
4.2
3.9
7.36
7.35
ph
0.23
49
343
173
1477
1.24
1.58
3.6
3.1
0.20
0.38
e6/l
1.64
114
1050
7
26
2.71
1.58
1.6
1.7
—
—
—
0
0
190
1641
1.23
1.56
3.6
3.2
0.02
0.01
estimate
0.18
54
497
14
71
2.00
1.55
4.5
3.2
1.29
1.32
%
0.02
14
65
31
201
1.57
1.54
2.6
2.1
1.23
1.50
g/l
0.86
25
178
20
115
1.76
1.54
4.8
3.3
53.32
58.06
%
0.84
20
115
17
93
1.85
1.53
8.2
3.1
—
—
—
0
0
144
1211
1.25
1.51
1.8
2.0
—
—
—
0
0
12
58
2.09
1.50
1.6
1.8
18.80
28.23
ng/l
0.69
12
58
12
58
2.09
1.50
1.9
1.5
32.25
32.69
pg
0.10
12
58
67
510
1.35
1.48
3.7
4.1
8.07
22.57
ug/l
0.73
56
417
39
271
1.47
1.43
11.6
6.7
25.13
24.54
mmol/l
0.58
39
259
56
417
1.38
1.42
5.2
3.7
1.23
1.23
mmol/l
0.05
47
355
94
757
1.29
1.41
1.4
1.2
—
—
—
0
0
10
46
2.19
1.40
1.3
1.2
—
—
—
0
0
29
191
1.54
1.37
3.7
3.7
462.55
342.79
mg/l
0.19
11
68
28
183
1.56
1.37
1.4
1.3
—
—
—
0
0
5
17
2.96
1.36
1.0
1.8
61.40
76.06
nmol/24h
—
5
17
16
90
1.80
1.34
5.0
3.7
3.47
4.24
e9/l
1.03
16
90
17
99
1.74
1.28
2.9
2.8
4.88
7.57
umol/l
0.49
12
75
8
35
2.30
1.27
6.0
3.1
2603.75
950.66
mg
—
8
35
9
45
2.01
1.23
4.2
2.6
—
—
—
0
0
153
1323
1.21
1.22
2.5
2.1
—
—
—
0
0
33
230
1.46
1.22
3.4
3.9
—
—
—
0
0
151
1305
1.21
1.21
4.0
3.7
1.02
1.02
kg/l
1.07
99
851
17
101
1.70
1.21
5.5
2.7
10.15
7.95
pmol/l
0.32
17
101
15
86
1.76
1.20
5.1
7.8
9.67
10.81
mmol/l
0.69
15
78
15
86
1.76
1.20
5.1
7.8
104.07
105.50
mmol/l
0.42
15
78
0
33
0.00
1.16
0.0
1.1
—
—
—
0
0
60
468
1.31
1.16
1.2
1.2
101.04
155.40
u/ml
1.03
31
201
81
659
1.26
1.14
1.6
1.6
—
—
—
0
0
195
1736
1.18
1.13
3.7
3.2
41.47
55.12
e6/l
0.35
138
1303
7
31
2.27
1.10
1.0
1.1
13.43
8.52
mm/h
—
7
31
37
498
0.73
1.09
2.2
1.7
3.42
3.41
mmol/l
0.02
24
358
10
52
1.94
1.06
2.0
1.1
92.40
113.79
pmol/l
—
10
52
5
22
2.28
1.03
1.0
1.9
—
—
—
0
0
99
835
1.22
1.02
3.1
3.1
2.09
3.35
e6/l
1.15
42
389
26
180
1.46
1.02
2.8
2.0
2.76
4.00
iu/l
0.78
15
79
65
523
1.27
1.01
8.8
7.5
7.43
7.42
ph
0.72
37
298
41
310
1.35
0.99
2.0
2.3
5685.29
4980.70
u/l
0.07
12
142
9
49
1.85
0.99
1.3
1.2
—
—
—
0
0
58
462
1.28
0.98
8.6
7.8
96.29
95.94
%
0.31
58
450
15
235
0.63
0.98
1.9
1.5
—
—
—
0
0
12
69
1.75
0.97
3.0
2.3
—
—
—
0
0
12
69
1.75
0.97
1.9
1.4
—
—
—
0
0
0
32
0.00
0.95
0.0
14.6
—
870.00
—
0
32
34
252
1.37
0.94
10.2
9.2
15.08
15.59
%
0.63
34
243
195
1760
1.16
0.94
2.5
2.2
—
—
—
0
0
64
520
1.26
0.93
8.6
7.5
1.63
0.81
mmol/l
0.93
57
439
53
421
1.28
0.93
1.3
1.2
—
—
—
0
0
6
28
2.15
0.91
2.5
1.8
66.50
49.33
ug/l
—
6
28
57
459
1.27
0.90
3.0
2.3
6.13
6.12
ph
0.02
42
291
10
169
0.58
0.89
2.0
1.9
—
—
—
0
0
23
161
1.45
0.88
2.7
4.1
25.32
30.44
mg/l
0.35
18
135
23
161
1.45
0.88
2.7
4.1
71.18
50.35
mg/l
0.32
18
136
12
72
1.68
0.85
1.1
1.2
—
—
—
0
0
17
250
0.67
0.85
1.9
1.5
—
—
—
0
0
28
205
1.38
0.85
1.5
1.6
36.75
9.58
u/ml
—
6
44
17
249
0.67
0.84
1.9
1.5
—
—
—
0
0
13
201
0.64
0.82
1.6
1.4
—
—
—
0
0
17
247
0.68
0.81
1.5
1.5
—
—
—
0
0
17
246
0.68
0.79
1.9
1.5
—
—
—
0
0
63
523
1.23
0.78
9.1
7.5
12.26
12.26
kpa
0.00
63
507
6
34
1.77
0.76
1.3
1.4
65.00
68.56
umol/l
—
6
34
12
185
0.64
0.76
1.2
1.5
—
—
—
0
0
466
4505
1.15
0.75
23.7
17.3
13.65
13.53
%
1.07
460
4454
53
434
1.24
0.75
10.4
7.6
115.87
119.44
g/l
0.67
53
426
9
54
1.68
0.74
1.7
2.4
—
—
—
0
0
7
38
1.85
0.73
5.1
1.8
46.67
41.13
%
—
7
38
54
445
1.23
0.73
1.4
1.5
—
—
—
0
0
5
25
2.01
0.73
3.0
1.7
14.24
17.80
%
—
5
25
6
110
0.54
0.72
1.2
1.4
3.67
2.75
ug/l
—
6
101
10
60
1.68
0.72
2.9
2.1
—
—
—
0
0
7
41
1.72
0.70
1.0
1.0
—
—
—
0
0
9
58
1.56
0.70
1.4
1.2
—
—
—
0
0
19
135
1.42
0.70
3.1
2.8
0.60
1.63
index
—
10
68
116
1031
1.16
0.69
1.6
1.7
—
—
—
0
0
11
69
1.61
0.68
1.3
1.3
—
—
—
0
0
11
69
1.61
0.68
1.3
1.3
—
—
—
0
0
11
69
1.61
0.68
1.3
1.3
—
—
—
0
0
11
69
1.61
0.68
1.3
1.3
—
—
—
0
0
13
191
0.67
0.67
1.2
1.6
—
—
—
0
0
131
1177
1.14
0.67
3.2
2.5
4.67
6.83
e6/l
1.33
114
1070
20
271
0.73
0.67
1.2
1.1
—
—
—
0
0
59
496
1.21
0.67
2.3
2.3
32.36
37.63
u/l
0.50
47
418
33
263
1.27
0.61
2.1
2.0
—
—
—
0
0
8
52
1.55
0.59
1.3
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.5
—
—
—
0
0
13
89
1.47
0.58
1.6
1.6
—
—
—
0
0
8
54
1.49
0.57
1.0
1.1
—
—
—
0
0
8
55
1.46
0.56
2.1
1.9
89.89
90.45
%
—
8
55
15
107
1.41
0.56
1.3
1.3
—
—
—
0
0
10
65
1.55
0.55
4.6
2.7
—
—
—
0
0
6
37
1.63
0.55
3.0
1.0
281.00
297.69
mg/l
—
6
32
6
38
1.58
0.54
1.0
1.1
201.67
203.39
mg/l
—
6
33
47
397
1.20
0.53
7.4
8.2
—
—
—
0
0
6
100
0.60
0.52
1.8
1.2
49.67
62.66
mmol/l
—
6
86
6
40
1.50
0.51
1.2
1.2
—
—
—
0
0
30
243
1.25
0.50
1.3
1.4
156.53
248.00
miu/ml
0.75
17
120
6
41
1.47
0.50
1.2
1.1
—
—
—
0
0
7
108
0.64
0.49
1.0
1.1
—
—
—
0
0
7
108
0.64
0.49
1.0
1.1
—
—
—
0
0
7
46
1.53
0.48
1.3
1.3
—
—
—
0
0
7
49
1.43
0.46
1.0
1.1
—
—
—
0
0
209
2207
0.92
0.43
3.7
3.0
—
—
—
0
0
5
33
1.52
0.41
1.0
1.0
1020.00
599.08
ng/l
—
5
24
5
33
1.52
0.41
1.4
1.1
1.12
1.06
ratio
—
5
28
5
33
1.52
0.41
1.0
1.0
195.60
337.04
ng/l
—
5
24
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
15
115
1.31
0.39
1.1
1.8
—
—
—
0
0
16
124
1.30
0.39
1.3
1.2
4.00
92.51
e6/l
—
9
101
52
458
1.15
0.39
5.8
3.8
—
—
—
0
0
16
203
0.78
0.38
1.1
1.1
1.58
1.59
g/l
0.05
16
203
9
67
1.35
0.38
1.4
1.3
—
—
—
0
0
31
262
1.19
0.37
3.2
2.9
1.02
1.02
ratio
0.56
26
241
175
1654
1.08
0.37
4.8
3.8
0.00
0.01
estimate
0.96
60
587
9
71
1.27
0.36
5.4
6.7
337.56
379.91
umol/l
—
9
65
6
42
1.43
0.35
1.2
1.1
29.33
29.56
mg/l
—
6
35
15
117
1.29
0.35
1.5
1.8
—
—
—
0
0
85
779
1.11
0.35
5.7
5.5
2.07
2.68
ug/l
0.59
73
701
13
100
1.31
0.34
1.1
1.1
4.44
0.91
u/ml
—
5
50
17
209
0.81
0.32
1.2
1.1
0.81
0.89
g/l
1.07
17
209
18
146
1.24
0.32
3.0
3.8
7.50
3.21
ratio
—
7
80
12
92
1.31
0.32
1.3
1.0
—
—
—
0
0
7
53
1.32
0.31
1.7
2.7
—
—
—
0
0
11
84
1.32
0.30
1.1
1.1
6.61
5.20
u/ml
—
6
32
8
109
0.73
0.29
1.1
1.6
—
—
—
0
0
15
121
1.25
0.28
1.1
1.1
4.42
2.86
u/ml
—
7
68
13
162
0.80
0.28
1.0
1.3
6.10
10.19
u/l
—
8
129
136
1290
1.07
0.27
2.9
1.7
1.11
1.21
mg/l
0.18
107
1005
15
123
1.23
0.25
1.3
1.2
1.25
7.95
e6/l
—
8
98
65
703
0.92
0.25
1.5
1.5
—
—
—
0
0
11
87
1.27
0.24
1.3
1.2
—
—
—
0
0
16
190
0.84
0.23
1.1
1.1
—
0.68
—
0
22
13
106
1.23
0.23
1.6
1.4
—
—
—
0
0
11
88
1.25
0.22
1.7
1.2
2.00
3.64
u/ml
—
6
33
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
7354.30
—
0
10
0
10
0.00
0.21
0.0
1.0
—
8.55
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
11
89
1.24
0.21
1.3
1.0
—
—
—
0
0
17
145
1.18
0.20
9.2
3.7
1.61
1.25
mmol/l
0.78
17
140
0
14
0.00
0.20
0.0
1.1
—
46.04
—
0
8
10
121
0.82
0.18
2.5
3.7
—
—
—
0
0
7
60
1.17
0.18
1.4
1.1
—
—
—
0
0
8
69
1.16
0.16
1.0
1.1
—
—
—
0
0
39
361
1.09
0.15
1.4
1.4
30.37
25.56
iu/l
0.37
34
307
46
431
1.07
0.14
6.7
7.0
1.43
1.33
mmol/l
0.35
46
424
10
84
1.19
0.14
1.2
1.2
—
—
—
0
0
20
222
0.90
0.14
2.7
1.8
—
—
—
0
0
24
219
1.10
0.13
1.5
1.5
0.36
0.31
mg/l
0.14
13
89
17
153
1.11
0.11
9.2
8.8
—
—
—
0
0
36
339
1.07
0.10
2.1
1.7
—
—
—
0
0
11
125
0.88
0.10
1.1
1.3
—
—
—
0
0
57
546
1.05
0.10
2.4
2.1
0.10
0.04
estimate
—
10
113
5
45
1.11
0.10
5.6
3.3
—
—
—
0
0
5
46
1.09
0.09
1.0
1.2
—
—
—
0
0
6
55
1.09
0.09
1.0
1.1
—
—
—
0
0
45
471
0.95
0.09
3.8
3.2
0.71
0.80
ug/l
0.56
34
299
7
64
1.09
0.08
1.6
1.3
—
—
—
0
0
6
71
0.84
0.07
1.8
1.1
—
—
—
0
0
30
284
1.06
0.07
1.8
2.1
0.09
0.01
estimate
0.39
11
89
74
761
0.97
0.07
1.4
1.8
—
—
—
0
0
9
102
0.88
0.06
3.1
2.2
56.17
58.71
%
—
9
102
14
152
0.92
0.06
1.1
1.2
—
—
—
0
0
13
120
1.09
0.05
2.2
4.0
38.29
28.93
mg/l
—
7
84
59
576
1.03
0.04
1.5
1.4
—
—
—
0
0
103
1014
1.02
0.04
3.6
2.7
477.60
519.63
mosm/kgh2o
1.26
84
885
12
129
0.93
0.03
1.0
1.1
—
—
—
0
0
18
188
0.96
0.02
1.6
1.3
—
—
—
0
0
70
690
1.02
0.02
1.7
1.8
—
—
—
0
0
26
253
1.03
0.01
3.7
2.6
0.70
0.62
%
0.46
26
253
166
1654
1.01
0.00
1.5
1.6
—
—
—
0
0
15
155
0.97
0.00
1.5
2.8
—
—
—
0
0
10
98
1.02
0.00
1.5
1.7
46.80
42.78
nmol/l
—
10
93
16
159
1.01
0.00
1.1
1.2
—
—
—
0
0
17
171
0.99
0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.73
—
0
5
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
52.00
—
0
8
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
96.00
—
0
6
5
52
0.96
-0.00
3.4
2.4
8.96
10.28
%
—
5
52
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.6
—
0.20
—
0
7
0
9
0.00
-0.00
0.0
4.4
—
5.21
—
0
9
0
7
0.00
-0.00
0.0
6.0
—
7.33
—
0
7
6
69
0.87
-0.00
1.2
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_GRANUANNU and mortality.

Females

Parameter HR [95% CI] p-value
L12_GRANUANNU 0.932 [0.77, 1.13] 0.465
Birth year 0.995 [0.99, 1.0] 0.213

During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 2180 females with L12_GRANUANNU died.

Males

Parameter HR [95% CI] p-value
L12_GRANUANNU 1.372 [1.06, 1.78] 0.018
Birth year 0.989 [0.98, 1.0] 0.019

During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 691 males with L12_GRANUANNU died.

Mortality risk

Mortality risk for people of age

years, who have L12_GRANUANNU.

N-year risk Females Males
1 0.093% 0.277%
5 0.604% 1.707%
10 1.334% 4.135%
15 2.672% 7.778%
20 4.563% 13.472%

Relationships between endpoints

↥

Index endpoint: L12_GRANUANNU – Granuloma annulare

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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