Foreign body granuloma of skin and subcutaneous tissue

L12_FOREIGNBODYGRANULOMA

granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L92.3 Hospital discharge: ICD-9 — 7094 Cause of death: ICD-10 — L92.3 Cause of death: ICD-9 — 7094 2 out of 7 registries used, show all original rules.	141
4. Check minimum number of events None	141
5. Include endpoints None	141
6. Filter based on genotype QC (FinnGen only)	127

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L92
Name in latin: Granuloma cutis vel telae subcutaneae ex corpore alieno

NAME	L12_FOREIGNBODYGRANULOMA
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L923
HD_ICD_9	7094
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L923
COD_ICD_9	7094
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Foreign body granuloma of skin and subcutaneous tissue based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1088	532	551
Only index persons	970	472	498
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	42.35	44.17	40.60
Only index persons	42.59	44.60	40.67

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	127	74	53
Unadjusted period prevalence (%)	0.03	0.03	0.02
Median age at first event (years)	49.19	48.49	50.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
133: Matched controls
1330

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L92.3

ICD-10 Finland

Foreign body granuloma of skin and subcutaneous tissue

+∞

151.6

115

7094A

ICD-9 Finland

Other disorders of skin and subcutaneous tissue, Foreign body granuloma of skin and subcutaneous tissue

+∞

19.2

QCE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in upper limb

17.2

9.3

9736

FHL

Subcutaneous tumor removal in operating room or anesthesia

47.8

7.8

M79.5

ICD-10 Finland

Residual foreign body in soft tissue

15.3

6.5

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

125

2.81

5.28

2.4

1.5

—

(3022096) Basophils/Leukocytes in Blood

543

2.06

3.97

7.4

6.6

0.68

0.69

0.04

508

(4024509) Urine culture

3.32

3.95

1.3

1.7

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

2.66

3.91

4.5

2.3

0.25

0.19

e6/l

0.19

(3006504) Eosinophils/Leukocytes in Blood

546

2.04

3.87

7.4

6.5

2.98

2.86

0.21

513

(3019069) Monocytes/Leukocytes in Blood

551

2.01

3.72

7.3

6.7

8.47

8.57

0.11

520

(3035350) Ketones [Presence] in Urine by Test strip

610

2.02

3.70

5.7

3.9

0.00

estimate

-0.00

125

(3009261) Glucose [Presence] in Urine by Test strip

622

2.02

3.63

5.6

4.0

0.00

estimate

-0.00

119

(3021601) Nitrite [Presence] in Urine by Test strip

605

1.99

3.56

5.7

3.9

0.00

estimate

-0.00

121

(3041096) Erythrocytes [Presence] in Urine by Automated

333

1.98

3.48

6.2

3.1

0.00

estimate

-0.00

100

(3002030) Lymphocytes/Leukocytes in Blood

563

1.93

3.37

7.3

6.8

31.17

28.79

1.19

539

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

172

2.13

3.17

1.7

1.8

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.07

3.05

1.3

—

(3032080) INR in Blood by Coagulation assay

504

1.82

2.90

24.0

10.5

1.28

1.18

inr

0.81

418

(3015736) pH of Urine

496

1.81

2.86

4.9

3.5

6.31

6.19

0.51

271

(3013115) Eosinophils [#/volume] in Blood

617

1.80

2.72

7.4

7.0

0.21

0.19

e9/l

0.36

540

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

2.49

2.71

1.4

1.3

—

28.25

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

139

2.08

2.60

1.5

1.6

—

(3001604) Monocytes [#/volume] in Blood

595

1.75

2.54

6.7

6.6

0.60

0.56

e9/l

0.55

508

(3006315) Basophils [#/volume] in Blood

596

1.75

2.51

6.8

6.6

0.04

e9/l

0.10

509

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

253

1.83

2.46

1.6

1.7

1.36

1.30

mg/l

0.04

201

(3019198) Lymphocytes [#/volume] in Blood

609

1.73

2.44

6.8

6.6

2.02

2.05

e9/l

0.05

537

(42870588) Differential panel, method unspecified - Blood

395

1.72

2.37

7.4

5.9

—

(3042936) Bacteria identified in Isolate by Culture

160

1.95

2.33

1.8

1.9

—

(3021788) Differential panel - Synovial fluid

4.04

2.28

1.6

1.3

—

(3000850) Epithelial cells [#/volume] in Urine

250

1.79

2.28

6.7

2.6

3.80

5.17

e6/l

0.62

230

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

5.72

2.23

1.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

132

2.00

2.22

1.6

1.7

—

(3018095) Leukocytes [#/volume] in Urine

434

1.65

2.07

6.6

4.2

17.73

99.85

e6/l

1.46

297

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

456

1.62

1.99

6.3

3.7

0.00

estimate

-0.00

102

(3044941) Cell count panel - Synovial fluid

3.87

1.96

1.3

—

(3010421) pH of Blood

2.97

1.89

7.5

2.5

7.41

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

3.64

1.86

1.0

1.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

749

1.62

1.82

3.2

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.87

1.82

2.1

3.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.87

1.82

1.3

1.8

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.90

1.67

1.3

1.8

—

(40768443) Skin Pathology biopsy report

2.37

1.59

1.0

1.2

—

(3011288) Drugs identified in Urine by Screen method Nominal

2.51

1.56

2.1

1.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

2.26

1.55

1.5

1.9

—

(3044290) Cell count panel - Cerebral spinal fluid

2.94

1.52

1.7

1.1

—

(40761536) Microorganisms panel - Urine sediment

2.03

1.50

8.5

3.6

—

(3002582) Erythrocytes [#/volume] in Urine

386

1.52

1.49

6.3

3.3

12.45

213.90

e6/l

0.62

289

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.40

1.46

2.3

1.2

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

2.81

1.45

1.3

1.8

—

(44790047) Parainfluenza type 1 nucleic acid detection

3.20

1.45

1.4

1.8

—

(44790049) Parainfluenza type 3 nucleic acid detection

3.20

1.45

1.4

1.8

—

(44790048) Parainfluenza type 2 nucleic acid detection

3.20

1.45

1.4

1.8

—

(44806118) Parainfluenza type 4 nucleic acid detection

3.20

1.45

1.4

1.8

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

855

1.56

1.42

6.7

4.7

11.02

11.07

mm/h

0.01

800

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.49

1.41

1.3

1.8

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.68

1.38

1.3

1.5

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

869

1.54

1.36

4.7

4.4

14.41

14.76

pmol/l

0.73

809

(3013650) Neutrophils [#/volume] in Blood by Automated count

673

1.47

1.35

7.2

11.2

3.91

3.92

e9/l

0.02

579

(3028300) Cannabinoids [Presence] in Urine

2.17

1.31

2.3

1.3

—

(3027008) Opiates [Presence] in Urine

2.17

1.31

2.2

1.3

—

(3026782) Osmolality of Urine

224

1.56

1.31

5.3

2.7

540.75

531.96

mosm/kgh2o

0.07

198

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

557

1.45

1.30

12.6

7.2

1.22

1.21

mmol/l

0.56

495

(3000764) Benzodiazepines [Presence] in Urine

2.13

1.25

2.2

1.3

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

219

1.54

1.22

1.4

1.3

18.51

32.69

iu/ml

—

(3027944) Amphetamines [Presence] in Urine

2.08

1.20

2.3

1.3

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

179

1.56

1.14

7.2

4.0

0.81

mmol/l

0.03

170

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.33

1.12

1.3

1.8

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.01

1.11

17.8

2.3

23.55

24.02

mmol/l

—

(3021901) Oxygen saturation in Capillary blood

2.43

1.10

14.8

2.7

91.90

89.68

—

(3045414) Leukocytes [Presence] in Urine

106

1.69

1.09

2.5

2.1

0.00

estimate

—

(3017181) Myelocytes/Leukocytes in Blood

1.72

1.09

4.3

0.43

0.86

—

(3016879) Cocaine [Presence] in Urine

2.07

1.07

2.3

1.3

—

(4094501) Cardiovascular stress test using bicycle ergometer

2.18

1.07

1.3

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.70

1.05

2.4

3.0

—

(3044640) Blood type and Crossmatch panel - Blood

381

1.41

1.05

2.0

2.4

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.12

1.04

1.7

1.9

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

209

1.50

1.04

4.8

3.3

1962.37

176.04

ng/l

0.43

150

(3020682) Albumin/Creatinine [Ratio] in Urine

363

1.41

1.04

4.4

3.9

6.37

8.07

mg/mmol

0.17

216

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

420

1.39

1.02

3.1

3.8

21.67

36.62

ng/l

0.71

297

(3029937) Albumin [Presence] in Urine by Test strip

336

1.41

1.02

6.2

3.8

0.00

estimate

-0.00

113

(3049717) Cytology report of Urine Cyto stain

2.05

1.01

2.7

2.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.05

1.01

1.7

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

859

1.42

1.01

8.5

8.7

76.48

77.61

u/l

0.11

819

(3023368) Bacteria identified in Blood by Culture

303

1.41

0.95

4.3

4.0

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

2.28

0.95

1.0

1.1

—

1.10

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

542

1.35

0.92

3.2

2.7

—

estimate

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

207

1.45

0.89

1.3

13.75

9.57

u/ml

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.78

0.89

1.6

3.6

0.65

0.69

0.14

(3026008) Bacteria identified in Urine by Culture

325

1.38

0.89

4.9

3.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.75

0.85

1.6

3.7

0.95

1.28

0.82

(3021960) Folate [Moles/volume] in Serum or Plasma

318

1.37

0.85

1.8

1.7

23.05

21.29

nmol/l

0.25

261

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

263

1.39

0.85

1.4

1.6

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.71

0.85

1.1

1.2

—

(3022313) Gas panel - Capillary blood

1.78

0.82

17.5

3.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.68

0.81

1.0

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.66

0.78

1.9

1.4

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.80

0.77

1.5

1.4

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.80

0.77

1.3

1.4

—

(3019309) Folate [Moles/volume] in Red Blood Cells

179

1.42

0.73

1.5

1.6

1141.25

1156.53

nmol/l

0.03

136

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.96

0.71

1.2

1.9

—

(3012544) pH of Venous blood

119

1.49

0.71

7.5

4.0

7.38

7.39

0.05

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

189

0.65

0.70

1.5

1.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.70

0.69

1.3

1.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

119

1131

1.50

0.68

21.0

14.5

23.07

23.81

mg/l

0.09

103

928

(3012516) Albumin [Mass/volume] in Urine

360

1.29

0.63

4.3

3.2

58.15

50.64

mg/l

0.07

224

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.59

0.0

2.5

—

45.72

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.59

0.0

1.6

—

(3002179) Metamyelocytes/Leukocytes in Blood

1.46

0.53

4.3

3.9

0.60

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.51

0.52

1.4

3.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

265

1.27

0.51

5.4

5.5

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.49

0.50

9.9

5.6

24.70

24.20

mmol/l

0.21

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

184

1.30

0.47

2.0

1.7

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

1.45

0.47

14.0

3.8

0.76

0.87

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.45

0.47

1.3

1.2

—

(3021589) Normoblasts [#/volume] in Blood

529

1.21

0.46

9.6

10.7

0.00

0.01

e9/l

0.54

415

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.42

0.46

2.1

2.4

—

(3030467) Casts [#/volume] in Urine by Automated count

327

1.23

0.44

6.0

3.2

0.30

0.25

e6/l

0.11

233

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.48

0.44

12.4

3.5

1.10

1.60

—

(3018418) pH of Serum or Plasma

337

1.22

0.43

6.0

4.4

7.39

0.20

240

(3008898) HLA-B27 [Presence]

1.40

0.42

1.0

1.1

—

(3047181) Lactate [Moles/volume] in Blood

1.53

0.42

10.8

5.1

1.14

1.23

mmol/l

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

1.53

0.42

3.4

4.7

19.80

26.94

mg/l

—

(4062490) Immunoglobulin typing, IgG

0.00

0.41

0.0

1.1

—

(3028192) IgG subclass 2 [Mass/volume] in Serum

0.00

0.41

0.0

1.1

—

2.94

—

(3024139) IgG subclass 3 [Mass/volume] in Serum

0.00

0.41

0.0

1.1

—

0.55

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.41

0.0

3.0

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.41

0.0

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

133

1.32

0.41

2.4

1.5

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.49

0.41

1.0

1.5

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.44

0.39

1.4

1.2

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

190

1.25

0.38

2.7

3.2

1.33

3.37

e6/l

1.14

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

304

1.21

0.37

1.3

1.4

1.38

1.25

u/ml

0.07

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.29

0.37

1.9

3.4

4.54

4.60

pmol/l

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

539

1.17

0.35

3.2

3.1

122.68

105.67

ug/l

0.22

506

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.38

0.35

1.0

1.3

—

(3022145) Colonoscopy Study observation

143

0.75

0.34

1.1

1.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

203

1.22

0.33

2.7

3.0

0.55

0.80

e6/l

0.49

104

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.29

0.32

1.7

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

493

1.16

0.32

2.3

2.0

107.14

97.02

pmol/l

0.73

243

(4035726) Immunohistochemistry procedure

100

0.68

0.32

1.6

1.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

280

1.19

0.31

1.7

1.4

2.22

g/l

0.00

156

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

195

0.80

0.31

3.1

3.0

0.54

0.72

ug/l

—

127

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

123

1200

1.33

0.31

14.0

11.7

26.75

26.11

u/l

0.20

123

1172

(40758558) Short blood count panel - Blood

370

1.16

0.28

4.1

7.0

—

(3022621) pH of Urine by Test strip

104

1.28

0.27

2.8

2.7

6.38

6.12

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.23

0.27

14.8

6.2

16.94

16.29

—

(3025941) Bacteria identified in Stool by Culture

1.23

0.27

1.5

1.2

—

(40768797) Stomach Pathology biopsy report

160

1.22

0.27

1.3

—

(1761868) Lipid panel - Serum or Plasma

461

1.14

0.25

2.9

3.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.20

0.25

2.6

1.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

288

1.15

0.22

2.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.5

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

11.6

—

958.09

—

(4027681) Cerebrospinal fluid IgG ratio and IgG index

0.00

0.21

0.0

1.1

—

0.51

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

9.6

—

0.65

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

83.40

—

(43055225) Phosphorylated tau 181 [Mass/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.21

0.0

1.1

—

34.20

—

(3000242) Tau protein [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

242.60

—

(3042810) Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

570.60

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

3.68

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.21

0.0

1.6

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.1

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.0

—

(3014037) CD3+CD4+ (T4 helper) cells/cells in Blood

0.00

0.21

0.0

2.1

—

46.00

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.26

0.20

2.0

1.7

10.50

29.64

iu/l

—

(40761511) CBC panel - Blood by Automated count

120

1176

1.21

0.20

18.2

12.3

—

(3045424) Erythrocytes [Presence] in Urine

1.22

0.18

4.1

2.3

—

0.00

estimate

—

(1002224) Polysomnography panel

1.16

0.18

1.0

1.1

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.19

0.17

8.4

3.9

24.07

24.38

mmol/l

—

(3019060) Gas panel - Arterial blood

1.15

0.16

7.0

3.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.15

0.16

1.6

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

119

0.83

0.16

4.2

1.8

—

(3033658) Prothrombin time (PT) actual/Normal

312

0.91

0.13

4.3

3.5

88.86

93.65

0.44

307

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

136

0.87

0.11

3.8

1.9

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

1.17

0.10

1.2

1.55

1.52

g/l

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

1.14

0.10

1.2

0.91

0.89

g/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.06

0.08

1.3

—

(3003694) ABO and Rh group [Type] in Blood

327

0.93

0.08

1.7

1.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.80

0.08

3.2

1.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.83

0.07

1.1

1.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

234

0.93

0.07

2.7

1.9

—

(36660697) Celiac disease serology panel - Serum

110

1.10

0.05

1.1

1.2

—

(3000492) Spirometry study

130

1.09

0.05

1.5

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

140

0.92

0.04

9.9

5.7

4.89

5.03

kpa

0.31

132

(3027801) Oxygen [Partial pressure] in Arterial blood

140

0.92

0.04

9.9

5.7

10.57

12.44

kpa

1.90

133

(40768804) Tissue Pathology biopsy report

460

1.03

0.03

2.0

2.1

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

252

1.04

0.02

5.4

4.9

18.48

21.52

—

124

(3019832) Treponema pallidum Ab [Presence] in Serum

113

1.07

0.02

2.7

1.8

—

(3016502) Oxygen saturation in Arterial blood

126

0.95

0.00

7.3

6.1

96.11

96.32

0.09

121

(21494755) Public health laboratory ask at order entry panel

136

0.95

0.00

1.6

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

114

0.96

0.00

1.8

—

(3000494) Fungus identified in Specimen by Culture

144

0.97

0.00

1.9

1.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

141

0.99

0.00

1.2

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

113

0.97

0.00

6.0

7.6

—

(3000991) Gas panel - Venous blood

112

0.98

0.00

10.2

7.2

—

(3003396) Base excess in Arterial blood by calculation

138

1.02

0.00

8.6

5.9

2.25

0.88

mmol/l

—

113

(3002256) Pathology report gross observation

155

0.96

0.00

1.0

1.3

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

105

0.95

0.00

4.4

6.5

1.23

1.20

mmol/l

—

105

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

105

0.95

0.00

1.6

1.5

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.4

—

8.90

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.98

0.00

3.2

1.5

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.2

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

-0.00

0.0

1.0

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

3.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.89

-0.00

24.6

7.4

23.97

24.91

mmol/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.00

-0.00

1.0

1.5

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.0

—

8.81

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

2.0

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

-0.00

0.0

1.0

—

147.00

—

(3020891) Body temperature

0.92

-0.00

2.0

5.3

37.00

36.91

°c

—

(3005719) IgG [Mass/volume] in Serum or Plasma

0.92

-0.00

5.6

2.9

9.14

10.21

g/l

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(42868417) European tick borne encephalitis virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.1

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.2

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3030313) Adrenal Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3035062) Alkaline phosphatase.liver 1 [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

87.29

—

(3040370) OLANZapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

132.17

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

-0.00

0.0

1.2

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3036185) Alkaline phosphatase.liver 2 [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

29.14

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.97

-0.00

1.4

1.3

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.0

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

160

1.00

-0.00

5.0

6.4

103.69

104.25

mmol/l

0.11

160

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

15.00

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

119.29

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.7

—

4.49

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.0

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.2

—

(3034426) Prothrombin time (PT)

0.00

-0.00

0.0

1.4

—

28.14

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.2

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.3

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.1

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

1.4

—

1.84

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

41.27

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

-0.00

0.0

1.0

—

44.73

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

76.20

—

(3045142) Bone marrow Pathology biopsy report

0.00

-0.00

0.0

1.4

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

2.1

—

17.11

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_FOREIGNBODYGRANULOMA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_FOREIGNBODYGRANULOMA.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_FOREIGNBODYGRANULOMA – Foreign body granuloma of skin and subcutaneous tissue

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Foreign body granuloma of skin and subcutaneous tissue

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints