granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
244 |
4. Check minimum number of eventsNone |
244 |
5. Include endpointsNone |
244 |
6. Filter based on genotype QC (FinnGen only) |
216 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L92
- Name in latin
- Necrobiosis lipoidica non alibi classificata
Similar endpoints
↥List of similar endpoints to
Necrobiosis lipoidica, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Granulomatous disorders of skin and subcutaneous tissue
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1091 | 836 | 253 |
| Only index persons | 1019 | 789 | 230 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.63 | 46.08 | 48.41 |
| Only index persons | 45.18 | 44.62 | 47.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 216 | 167 | 49 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | 36.96 | 34.78 | 44.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 221
- Matched controls
- 2210
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L92.1
ICD-10 Finland
Necrobiosis lipoidica, not elsewhere classified
+∞
300.4
214
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
47.7
149.6
96
35
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
89.0
147.9
80
14
A10AB01
ATC
insulin (human); parenteral
41.9
146.7
99
42
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
35.5
145.6
107
57
H04AA01
ATC
glucagon; nasal, parenteral
46.9
131.5
83
28
A10AB05
ATC
insulin aspart; parenteral
25.7
128.6
112
85
A10AE05
ATC
insulin detemir; parenteral
29.2
115.9
88
49
A10AE04
ATC
insulin glargine; parenteral
20.5
115.4
117
115
A10AC01
ATC
insulin (human); parenteral
20.8
114.5
113
106
A10AB04
ATC
insulin lispro; parenteral
30.3
112.5
83
43
A10AA01, ,
ATC
33.2
109.6
77
35
A10AA02, ,
ATC
32.3
108.4
77
36
T89
ICPC
Diabetes insulin dependent
23.3
104.2
88
61
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
33.3
102.2
71
31
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
53.6
85.1
50
12
103
Kela drug reimbursment
Diabetes, insulin-treated
12.9
83.5
147
295
215
Kela drug reimbursment
Diabetes, non-insulin-treated
12.5
82.2
143
282
A10AE06
ATC
insulin degludec; parenteral
21.5
79.4
66
43
E10
ICD-10 Finland
Type 1 diabetes mellitus
34.6
76.7
51
19
CKC12
NOMESCO Finland
Photocoagulation of retina
26.5
72.0
53
26
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
20.2
58.1
48
30
A10AD01
ATC
insulin (human); parenteral
27.7
57.7
41
18
SPAT1262
SPAT
Handing over of treatment supplies
8.5
53.6
96
183
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
21.0
50.1
40
23
XCK10
NOMESCO Finland
Photography of fundus of eye
9.7
49.4
70
101
H3603, E103,
ICD-10 Finland
257.7
42.5
42
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
10.2
42.0
54
68
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
16.3
40.0
36
26
S97
ICPC
Chronic ulcer skin
11.5
39.4
45
48
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
66.2
38.0
43
8
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
60.6
34.8
40
8
OAB50, ,
SPAT
8.3
33.4
50
75
177
Kela drug reimbursment
Insulin glargine 300 U / ml
13.7
31.4
31
26
H3600, E103,
ICD-10 Finland
61.0
31.4
36
7
H3601, E103,
ICD-10 Finland
66.5
30.1
34
6
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
51.6
29.7
35
8
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
74.4
28.8
32
5
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.0
27.6
82
235
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.7
27.6
43
67
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
306.3
27.4
27
*
D07AD01
ATC
clobetasol; topical
5.1
27.4
75
201
SPAT1148
SPAT
Treatment of chronic ulcer or burn
6.3
26.7
53
106
H36.00
ICD-10 Finland
Diabetic background retinopathy
51.2
26.3
31
7
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
35.8
24.5
31
10
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
97.8
24.2
26
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
38.3
24.0
30
9
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.1
23.8
47
93
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.7
23.3
51
111
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
36.8
23.1
29
9
H43.1
ICD-10 Finland
Vitreous haemorrhage
43.6
22.3
27
7
C10AA01
ATC
simvastatin; oral
3.7
19.7
92
355
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
9.3
19.7
25
30
H36.01
ICD-10 Finland
Diabetic maculopathy
33.4
18.8
24
8
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
17.4
18.6
29
19
C10AX09
ATC
ezetimibe; oral
4.3
18.2
58
170
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.8
17.9
74
261
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
68.9
17.0
19
*
E0000UV, ,
ATC
3.3
16.6
131
682
J01FF01
ATC
clindamycin; systemic
3.3
16.5
91
383
C10AA05
ATC
atorvastatin; oral
3.2
16.0
99
445
TQW80
NOMESCO Finland
Local dermatologic skincare
16.4
15.8
25
17
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
7.1
15.7
25
39
M65.3
ICD-10 Finland
Trigger finger
6.1
15.7
29
53
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
7.7
15.6
23
33
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
61.0
15.0
17
*
A10AA03, ,
ATC
23.0
15.0
21
10
L92.0
ICD-10 Finland
Granuloma annulare
86.0
14.8
16
*
H3602, E103,
ICD-10 Finland
160.1
14.6
15
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
14.3
118
614
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
14.3
48
145
171
Kela drug reimbursment
Degludekinsuliini
42.9
13.3
16
*
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
24.3
13.1
18
8
D07AC01
ATC
betamethasone; topical
2.8
12.9
106
543
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
19.4
12.3
18
10
C10AA07
ATC
rosuvastatin; oral
2.9
12.2
85
397
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.0
12.2
38
108
C03CA01
ATC
furosemide; systemic
3.1
12.2
65
262
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
3.1
12.2
64
256
CKC15
NOMESCO Finland
Panretinal photocoagulation
49.5
12.0
14
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.7
12.0
43
135
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
17.7
11.9
18
11
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
5.8
11.6
22
41
XF600
NOMESCO Finland
Bloodpressure measurement
5.2
11.5
25
53
A10BK01
ATC
dapagliflozin; oral
4.7
11.4
28
66
CKD40
NOMESCO Finland
Endophotocoagulation of retina
18.3
11.4
17
10
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
18.3
11.4
17
10
A46
ICD-10 Finland
Erysipelas
3.5
11.4
44
145
TK800
NOMESCO Finland
Hemodialysis
21.4
11.3
16
8
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
4.4
11.0
30
77
A10AB06
ATC
insulin glulisine; parenteral
29.7
10.9
14
5
Z94.0
ICD-10 Finland
Kidney transplant status
29.7
10.9
14
5
E000003, ,
ATC
5.4
10.8
22
44
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.2
10.7
11
557
D07AC13
ATC
mometasone; topical
2.7
10.6
83
407
127
Kela drug reimbursment
Transplant complication
20.0
10.4
15
8
B03XA02
ATC
darbepoetin alfa; parenteral
20.0
10.4
15
8
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
15.6
10.2
16
11
205
Kela drug reimbursment
Chronic hypertension
3.0
10.2
52
203
C09AA02
ATC
enalapril; systemic
3.1
10.1
49
185
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
42.1
10.1
12
*
T90
ICPC
Diabetes non-insulin dependent
2.8
10.1
62
268
E000001, ,
ATC
2.7
10.0
67
302
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
27.5
9.9
13
5
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.8
9.9
65
290
TPH04
NOMESCO Finland
Cathetrisation of vein
2.8
9.5
59
255
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
5.1
9.5
21
45
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
9.3
9.5
19
22
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
31.6
9.5
12
*
7098B
ICD-9 Finland
Other disorders of skin and subcutaneous tissue, Other specified disorders of skin[NECROBIOSIS LIPOIDICA]
+∞
9.4
9
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.6
9.4
23
54
XCD10
NOMESCO Finland
Electrophysiological examination of eye
8.3
9.4
20
26
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.8
9.3
58
251
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.8
9.3
30
87
ZZA00
NOMESCO Finland
Split skin graft
16.5
9.2
14
9
Z96.4
ICD-10 Finland
Presence of endocrine implants
38.4
9.1
11
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
25.2
9.0
12
5
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
25.2
9.0
12
5
ZXA10
NOMESCO Finland
Bilateral
2.8
9.0
56
242
ACC51
NOMESCO Finland
Release of median nerve
3.7
8.9
30
90
MAX99
NOMESCO Finland
Assistance to normal delivery
0.0
8.8
*
238
A10AD04
ATC
insulin lispro; parenteral
52.1
8.7
10
*
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
52.1
8.7
10
*
N18.8
ICD-10 Finland
Other chronic renal failure
21.0
8.6
12
6
L04AD02
ATC
tacrolimus; systemic
28.8
8.6
11
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.5
8.4
21
50
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
+∞
8.4
8
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.9
8.3
19
42
WZC30
NOMESCO Finland
Teaching
2.8
8.2
48
200
V03AE01
ATC
polystyrene sulfonate; oral
34.7
8.1
10
*
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
23.0
8.1
11
5
XCH00
NOMESCO Finland
Eye pressure measurement
4.9
8.0
18
39
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
13.7
8.0
13
10
J02AC01
ATC
fluconazole; systemic
2.2
7.9
119
758
C09AA05
ATC
ramipril; oral
2.7
7.9
50
217
Z3229
NOMESCO Finland
Other healthcare associate professional
3.6
7.8
27
82
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
46.7
7.8
9
*
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
46.7
7.8
9
*
S18
ICPC
Laceration/cut
2.2
7.6
109
677
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.4
7.6
19
32
J01MA14
ATC
moxifloxacin; systemic
3.5
7.6
28
89
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.7
7.5
48
209
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.6
7.5
26
79
K08.3
ICD-10 Finland
Retained dental root
3.8
7.5
24
69
A12AA04
ATC
calcium carbonate; oral
14.0
7.5
12
9
A63.0
ICD-10 Finland
Anogenital (venereal) warts
4.1
7.4
21
55
Z3231
NOMESCO Finland
Registered nurse
2.3
7.4
71
374
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
7.4
63
315
L92.9
ICD-10 Finland
Granulomatous disorder of skin and subcutaneous tissue, unspecified
+∞
7.3
7
*
MAA00
NOMESCO Finland
Amniocentesis
6.0
7.3
19
34
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.0
7.3
19
34
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
7.2
70
369
ZY010
NOMESCO Finland
Hospital outpatient
3.8
7.2
23
66
TQB05
NOMESCO Finland
Puncture of skin of trunk
31.1
7.2
9
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
7.4
7.1
16
23
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
10.5
7.1
13
13
L04AA06
ATC
mycophenolic acid; systemic
10.5
7.1
13
13
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.8
7.1
41
169
J01DA01
ATC
[U] cefalexin
2.2
7.1
151
1086
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
7.1
47
208
R4180
NOMESCO Finland
Podiatric therapy
14.4
7.0
11
8
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
14.4
7.0
11
8
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
8.7
6.9
14
17
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
4.5
6.9
17
40
J01MA02
ATC
ciprofloxacin; systemic
2.2
6.9
89
527
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
41.4
6.8
8
*
XQ848
NOMESCO Finland
Dermatological photography
6.3
6.8
17
29
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.3
6.7
26
85
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.0
6.7
31
113
ZXA05
NOMESCO Finland
Left side
2.4
6.7
57
284
R11
ICD-10 Finland
Nausea and vomiting
2.9
6.6
32
120
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
71.8
6.5
7
*
D03BA52
ATC
collagenase, combinations; topical
71.8
6.5
7
*
D03BA02
ATC
collagenase; topical
71.8
6.5
7
*
CL2L4
NOMESCO Finland
Wide-field fundus photography for diabetic retinopathy screening
71.8
6.5
7
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
71.8
6.5
7
*
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
71.8
6.5
7
*
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
14.9
6.5
10
7
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
6.9
6.5
15
23
N02AX02
ATC
tramadol; systemic, rectal
2.1
6.4
98
614
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.7
6.4
37
153
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
6.3
39
166
WX110
NOMESCO Finland
Infiltration anesthesia
2.4
6.3
176
1377
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
7.4
6.3
14
20
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
18.7
6.3
9
5
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.2
6.3
17
43
QXA20
NOMESCO Finland
Skin abrasion, unspecified location
+∞
6.3
6
*
JLE03
NOMESCO Finland
Allogenic total transplantation of pancreas with pancreaticoenterostomy
+∞
6.3
6
*
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
+∞
6.3
6
*
A10BA02
ATC
metformin; oral
2.2
6.2
63
336
Z3232
NOMESCO Finland
Midwife
0.1
6.2
*
224
WX002
NOMESCO Finland
Sedation and analgesia
2.4
6.2
46
215
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
13.0
6.1
10
8
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
6.4
6.1
15
25
SPAT1229
SPAT
Assessment of need for aid
3.9
6.1
18
49
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.2
6.0
24
80
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
154
515
7.56
47.81
8.9
4.2
18.66
8.30
mg/mmol
1.31
128
315
153
585
6.25
38.51
7.4
3.2
6.95
7.76
mmol/l
1.60
147
502
33
29
13.20
32.56
3.0
2.2
224.66
171.81
ug/min
0.14
26
17
49
120
4.96
19.41
8.5
3.2
113.65
80.89
ng/l
1.04
43
106
70
235
3.90
18.24
4.5
2.1
23.19
23.13
%
0.01
62
221
74
264
3.71
17.56
4.8
2.0
2.29
2.41
g/l
0.93
67
243
74
282
3.44
15.65
4.9
2.1
13.36
14.10
umol/l
0.34
67
262
112
582
2.87
13.40
1.9
1.3
2.05
1.17
u/ml
0.32
35
166
62
250
3.06
11.56
2.0
1.6
1172.48
1094.28
nmol/l
0.31
53
183
159
1040
2.89
11.55
9.9
4.9
9.93
6.39
mmol/l
14.32
151
953
123
761
2.39
9.19
12.4
4.4
34.04
36.89
g/l
5.41
116
718
35
114
3.46
9.15
2.3
1.4
—
—
—
0
0
128
817
2.35
8.76
2.8
1.9
1.35
1.35
mmol/l
0.02
116
729
29
88
3.64
8.41
3.5
2.3
-0.90
1.14
mmol/l
1.29
21
62
29
89
3.60
8.27
7.7
2.9
23.40
24.33
mmol/l
0.61
29
89
23
61
4.09
8.03
1.9
1.4
265.00
308.19
ug/g
0.46
15
34
97
572
2.24
7.76
7.1
2.7
55.12
55.75
u/l
0.03
91
528
47
202
2.69
7.55
9.5
7.1
103.62
104.78
mmol/l
1.06
47
202
39
154
2.86
7.34
8.5
11.5
0.67
0.54
mmol/l
0.07
32
125
26
81
3.50
7.24
6.5
2.3
0.66
0.59
%
0.38
26
81
133
909
2.16
7.14
4.4
2.5
70.97
75.35
nmol/l
1.21
124
843
84
481
2.20
7.10
3.4
2.1
2.77
2.70
mg/l
0.12
76
414
126
847
2.13
7.02
18.5
6.8
1.21
1.22
mmol/l
0.96
117
734
24
74
3.52
6.78
9.5
12.9
23.97
24.36
mmol/l
0.17
24
69
55
269
2.39
6.70
2.2
1.7
—
—
—
0
0
118
798
2.03
6.20
2.6
2.0
98.24
95.74
pmol/l
0.21
70
415
14
21
7.04
6.14
1.9
1.3
—
—
—
0
0
205
1748
3.39
5.77
15.7
5.3
55.07
37.92
mmol/mol
28.02
200
1663
17
46
3.92
5.76
2.3
1.2
—
—
—
0
0
30
117
2.81
5.75
3.6
3.0
65.33
76.71
ml/min/173m2
0.51
15
48
42
198
2.38
5.49
2.3
1.6
—
—
—
0
0
16
45
3.76
5.15
1.8
1.1
—
—
—
0
0
9
9
10.36
5.07
2.6
1.9
3212.33
919.44
mg
—
9
9
40
191
2.34
5.07
2.3
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
29
5.08
4.90
2.4
2.2
0.26
0.40
iu/ml
—
6
12
42
211
2.22
4.72
3.7
2.6
4.49
6.10
umol/l
1.12
33
179
21
76
2.95
4.59
3.7
2.3
161.25
111.68
ng/l
0.26
16
71
91
610
1.84
4.52
3.7
3.1
51.26
31.98
ng/l
0.66
60
341
185
1557
2.16
4.37
6.7
4.8
14.67
14.53
pmol/l
0.31
177
1460
39
198
2.18
4.26
1.3
1.3
123.29
135.24
u/ml
0.12
22
88
60
358
1.93
4.23
2.0
1.7
88000471.02
37500443.95
pmol/l
0.22
50
312
31
144
2.34
4.17
2.2
2.4
0.21
0.22
g/l
0.42
26
139
0
106
0.00
4.12
0.0
1.8
—
—
—
0
0
141
1110
1.75
3.80
12.2
9.4
4.67
3.99
e9/l
3.16
129
964
139
1099
1.71
3.60
6.3
3.3
100.59
76.26
ug/l
1.07
129
1039
170
1439
1.79
3.27
5.5
4.0
15.33
9.86
mm/h
4.40
160
1353
61
395
1.75
3.24
1.4
1.4
14.06
10.63
u/ml
0.11
22
155
12
35
3.57
3.16
1.1
1.1
—
—
—
0
0
13
41
3.30
3.11
2.4
1.5
—
—
—
0
0
6
8
7.67
3.07
1.2
1.1
—
—
—
0
0
10
266
0.35
2.93
1.6
1.9
3.60
3.39
ratio
—
5
209
5
6
8.49
2.76
2.8
1.5
0.57
0.62
mmol/l
—
5
6
7
14
5.12
2.75
1.1
1.0
—
—
—
0
0
32
179
1.92
2.69
5.6
2.6
25.69
28.40
u/l
0.24
26
151
20
94
2.24
2.64
2.0
1.5
—
—
—
0
0
62
426
1.63
2.59
1.5
1.4
10.24
24.57
iu/ml
2.73
16
128
5
7
7.27
2.56
1.4
1.4
110.80
110.14
%
—
5
7
6
11
5.57
2.56
1.2
1.0
1375.50
2146.73
miu/ml
—
6
11
10
33
3.12
2.39
1.2
1.1
—
—
—
0
0
128
1051
1.52
2.38
5.5
3.5
0.00
0.00
estimate
-0.00
26
214
5
8
6.36
2.38
1.2
1.3
—
—
—
0
0
7
17
4.22
2.38
2.0
2.6
105.71
107.00
mmol/l
—
7
17
7
17
4.22
2.38
2.0
2.6
1.17
1.18
mmol/l
—
7
17
129
1068
1.50
2.26
5.5
3.5
0.00
7.55
estimate
0.50
25
215
25
138
1.92
2.20
4.2
2.3
0.74
0.14
e6/l
0.52
25
130
29
169
1.82
2.17
1.4
2.3
7988.39
5096.12
u/l
—
10
73
10
36
2.86
2.16
8.3
2.4
14.39
7.74
pmol/l
—
10
36
129
1074
1.48
2.16
5.6
3.6
0.39
0.01
estimate
0.74
18
204
5
10
5.09
2.08
1.2
2.7
0.60
0.90
index
—
5
10
10
38
2.71
2.03
1.2
1.6
—
—
—
0
0
12
51
2.43
1.98
1.3
1.5
—
—
—
0
0
7
21
3.41
1.98
1.0
1.2
—
—
—
0
0
58
417
1.53
1.96
3.1
2.9
965.25
877.01
ng/l
0.12
49
352
11
45
2.52
1.96
1.3
1.5
—
—
—
0
0
28
168
1.76
1.92
4.5
2.9
—
—
—
0
0
17
86
2.06
1.91
1.7
1.4
—
—
—
0
0
42
285
1.58
1.83
5.3
2.8
7.33
3.37
e6/l
0.91
28
131
6
18
3.40
1.76
1.0
1.4
—
—
—
0
0
7
24
2.98
1.73
1.0
1.5
—
—
—
0
0
5
15
3.38
1.53
1.0
1.1
—
—
—
0
0
5
15
3.38
1.53
1.2
2.5
7.60
12.40
index
—
5
10
60
457
1.43
1.51
2.4
1.6
0.95
1.00
mg/l
0.07
48
349
44
316
1.49
1.49
4.8
3.2
160.90
323.44
ng/l
0.41
30
200
5
16
3.17
1.44
1.0
1.2
—
—
—
0
0
7
29
2.46
1.40
1.3
1.6
—
—
—
0
0
5
17
2.98
1.36
1.4
3.2
5.38
2.96
nmol/l
—
5
17
11
54
2.09
1.35
1.5
1.2
—
—
—
0
0
95
795
1.34
1.33
5.3
3.3
0.00
0.03
estimate
0.88
24
181
20
122
1.70
1.32
1.2
1.4
184.03
288.37
miu/ml
—
8
67
5
18
2.82
1.29
1.4
1.9
—
—
—
0
0
71
573
1.35
1.25
4.9
3.6
0.00
0.00
estimate
0.50
21
206
12
63
1.96
1.25
1.6
2.1
—
—
—
0
0
10
49
2.09
1.24
1.2
1.5
—
—
—
0
0
8
37
2.20
1.22
3.0
2.1
—
—
—
0
0
15
87
1.78
1.18
1.4
1.3
—
—
—
0
0
41
305
1.42
1.17
5.4
2.6
1.11
0.83
e6/l
0.34
29
150
8
39
2.09
1.16
1.4
1.6
—
—
—
0
0
65
524
1.34
1.15
2.3
1.6
18.05
21.45
nmol/l
1.24
59
452
5
21
2.41
1.09
1.2
1.2
—
—
—
0
0
11
59
1.91
1.09
1.5
1.9
—
—
—
0
0
7
34
2.09
1.04
2.4
1.5
—
—
—
0
0
9
159
0.55
1.03
1.4
1.5
—
—
—
0
0
21
141
1.54
0.99
1.3
1.3
—
33.36
—
0
10
5
23
2.20
0.98
1.4
1.7
15.92
16.88
%
—
5
23
6
27
2.26
0.94
1.0
1.3
—
—
—
0
0
13
78
1.71
0.93
4.5
2.2
3.78
4.73
iu/l
—
7
37
10
55
1.86
0.93
1.9
1.6
1.48
5.60
ug/l
—
10
50
11
63
1.79
0.92
3.5
2.4
13.73
10.01
g/l
1.05
11
56
12
72
1.70
0.87
3.3
2.3
3.88
4.08
g/l
0.12
12
66
12
72
1.70
0.87
3.3
2.3
7.57
7.43
g/l
0.10
12
66
12
72
1.70
0.87
3.3
2.3
4.45
4.37
g/l
0.10
12
66
8
44
1.85
0.87
3.4
2.5
—
—
—
0
0
200
1917
1.46
0.86
28.7
12.7
18.70
19.81
mg/l
0.25
183
1534
161
1497
1.28
0.86
3.7
3.8
—
—
—
0
0
61
509
1.27
0.83
7.1
2.8
0.21
0.32
e6/l
0.49
54
350
6
32
1.90
0.82
1.2
1.6
—
—
—
0
0
5
99
0.49
0.79
1.2
1.7
—
—
—
0
0
6
34
1.79
0.77
1.5
1.2
—
—
—
0
0
6
34
1.79
0.77
1.5
1.2
—
—
—
0
0
11
67
1.68
0.76
1.6
1.1
—
—
—
0
0
108
969
1.22
0.76
4.4
2.7
—
—
estimate
—
0
0
59
500
1.25
0.70
3.1
2.1
—
—
—
0
0
11
69
1.63
0.69
3.5
2.3
2.75
3.02
g/l
0.43
11
63
5
27
1.87
0.69
6.4
4.3
328.90
339.36
umol/l
—
5
22
22
163
1.39
0.67
6.9
5.1
—
—
—
0
0
11
71
1.58
0.63
1.4
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
3104.44
—
0
5
8
55
1.47
0.56
1.1
1.3
—
—
—
0
0
6
38
1.59
0.54
1.3
1.2
—
—
—
0
0
10
67
1.52
0.50
1.4
1.1
—
—
—
0
0
52
452
1.20
0.49
4.6
3.3
0.99
1.02
kg/l
0.51
40
277
14
187
0.73
0.48
1.4
1.5
—
—
—
0
0
43
496
0.83
0.46
1.5
1.6
—
—
—
0
0
151
1436
1.16
0.45
4.4
3.1
45.58
36.74
u/l
0.78
146
1374
63
563
1.17
0.44
1.7
1.7
—
—
—
0
0
17
131
1.32
0.43
1.5
1.3
—
—
—
0
0
17
131
1.32
0.43
1.3
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
12
88
1.38
0.41
1.7
1.7
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
17
134
1.29
0.38
1.1
1.0
—
—
—
0
0
188
1827
1.19
0.38
24.6
11.8
87.10
89.60
ml/min/173m2
0.64
183
1662
14
109
1.30
0.34
1.3
1.5
0.42
0.29
mg/l
—
7
43
39
343
1.17
0.33
2.5
2.5
2.44
2.43
mmol/l
0.19
34
303
6
46
1.31
0.33
1.3
1.2
—
—
—
0
0
17
141
1.22
0.27
1.3
1.6
206.75
290.12
mu/l
1.57
12
128
67
624
1.11
0.25
5.0
2.8
0.00
0.02
estimate
0.68
23
171
5
39
1.29
0.23
1.6
1.9
—
—
—
0
0
7
92
0.75
0.23
1.7
1.6
60.37
51.49
ug/l
—
7
92
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
7
60
1.17
0.18
5.9
2.7
3.17
0.29
g/l
—
7
55
21
235
0.88
0.17
2.0
2.0
—
—
—
0
0
20
189
1.06
0.05
1.3
1.3
34.19
18.61
iu/l
1.00
15
158
10
91
1.10
0.04
1.6
1.4
—
—
—
0
0
48
469
1.03
0.03
2.5
2.1
—
—
—
0
0
29
299
0.97
0.02
2.0
2.0
—
—
—
0
0
42
425
0.99
0.00
2.5
1.9
—
—
—
0
0
181
1808
1.01
0.00
5.9
4.3
7.79
5.74
mmol/l
13.55
172
1688
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
46.58
—
0
9
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.4
—
39.86
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
9
93
0.97
-0.00
2.3
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
-0.00
2.6
2.6
0.00
0.00
g/l
—
5
51
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_NECROLIPOIDIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NECROLIPOIDIC | 1.708 [1.34, 2.18] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.1 |
During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 716 females with L12_NECROLIPOIDIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NECROLIPOIDIC | 2.888 [1.87, 4.47] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.073 |
During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 221 males with L12_NECROLIPOIDIC died.
Mortality risk
Mortality risk for people of age
years, who have L12_NECROLIPOIDIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.139% | 0.603% |
| 5 | 0.876% | 3.629% |
| 10 | 2.311% | 8.801% |
| 15 | 4.605% | 16.114% |
| 20 | 7.926% | 26.721% |
Relationships between endpoints
↥Index endpoint: L12_NECROLIPOIDIC – Necrobiosis lipoidica, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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