No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
601 |
4. Check minimum number of eventsNone |
601 |
5. Include endpointsNone |
601 |
6. Filter based on genotype QC (FinnGen only) |
538 |
Control definitions (FinnGen only)
- Control exclude
- F5_SLEEP
Extra metadata
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Hypersomnia
based on the number of shared cases.
Similar with more cases:
- Sleep disorders
- Behavioural syndromes associated with physiological disturbances and physical factors
- Sleep disorders (combined)
- Psychiatric diseases
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2929 | 1404 | 1508 |
| Only index persons | 2812 | 1368 | 1444 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 43.74 | 39.88 | 47.34 |
| Only index persons | 43.55 | 39.80 | 47.10 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 538 | 318 | 220 |
| Unadjusted period prevalence (%) | 0.11 | 0.11 | 0.10 |
| Median age at first event (years) | 45.09 | 42.40 | 48.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 548
- Matched controls
- 5480
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G47.1
ICD-10 Finland
Disorders of excessive somnolence [hypersomnias]
13709.4
307.7
427
*
F51.1
ICD-10 Finland
Nonorganic hypersomnia
+∞
144.3
132
*
G47.3
ICD-10 Finland
Sleep apnoea
7.6
127.0
311
809
F51.0
ICD-10 Finland
Nonorganic insomnia
+∞
120.4
111
*
G47.9
ICD-10 Finland
Sleep disorder, unspecified
17.7
100.4
86
57
R06.5
ICD-10 Finland
Mouth breathing
6.8
74.5
139
262
N06AX12
ATC
bupropion; oral
6.8
63.9
115
207
N06AX16
ATC
venlafaxine; oral
5.0
61.2
170
453
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.0
57.1
153
394
N06BA07
ATC
modafinil; oral
85.3
55.3
61
8
N06AX11
ATC
mirtazapine; oral
3.8
51.8
256
1023
N06BA04
ATC
methylphenidate; oral
8.0
50.8
74
105
R53
ICD-10 Finland
Malaise and fatigue
3.8
49.7
228
863
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
11.1
46.4
51
50
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
6.4
45.2
82
147
N06AB04
ATC
citalopram; systemic
3.9
45.1
181
620
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
5.7
42.9
88
177
N05AH04
ATC
quetiapine; oral
3.7
37.7
154
527
N06AB06
ATC
sertraline; oral
4.1
37.6
126
376
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
5.9
37.1
72
137
N04BC05
ATC
pramipexole; oral
5.4
36.1
77
160
N06AX21
ATC
duloxetine; oral
3.9
34.4
118
357
R5140
NOMESCO Finland
Monitoring the use of the aid
3.9
33.1
114
345
N06AB10
ATC
escitalopram; oral
3.2
32.5
179
730
G47.4
ICD-10 Finland
Narcolepsy and cataplexy
175.2
32.1
33
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.9
31.3
106
316
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
5.8
31.3
61
116
Z01.8
ICD-10 Finland
Other specified special examinations
3.0
29.9
182
780
N06AB03
ATC
fluoxetine; oral
3.7
29.7
109
343
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
4.0
29.5
94
268
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.2
29.3
86
231
P03
ICPC
Feeling depressed
3.7
28.5
105
331
G47.0
ICD-10 Finland
Disorders of initiating and maintaining sleep [insomnias]
+∞
26.3
25
*
R06.0
ICD-10 Finland
Dyspnoea
2.7
25.5
188
881
N06AX03
ATC
mianserin; oral
6.0
25.2
46
82
TAB00
NOMESCO Finland
Lumbar puncture
4.7
24.3
59
136
N06AX26
ATC
vortioxetine; oral
4.0
24.3
76
213
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
4.7
23.8
59
138
N06AX22
ATC
agomelatine; oral
8.6
23.7
31
38
P06
ICPC
Sleep disturbance
3.3
22.9
97
332
N03AX09
ATC
lamotrigine; oral
4.5
22.9
60
147
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.4
22.3
90
299
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.1
22.1
105
385
N06AG02
ATC
moclobemide; oral
5.3
22.0
46
93
N06AA09
ATC
amitriptyline; systemic
3.8
21.7
71
205
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
6.3
21.5
37
62
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
3.1
21.5
103
379
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
21.0
189
960
F34.1
ICD-10 Finland
Dysthymia
5.2
20.5
44
91
N03AX16
ATC
[U] pregabalin
2.6
20.4
154
720
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
6.6
20.0
33
53
N06AX05
ATC
trazodone; oral
8.1
19.7
27
35
P29
ICPC
Psychological sympt/compl other
3.4
19.0
73
234
N05BA04
ATC
oxazepam; oral
2.5
18.9
161
793
J46
ICD-10 Finland
Status asthmaticus
7.1
18.9
29
43
R40.0
ICD-10 Finland
Somnolence
72.5
18.8
21
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.5
18.7
71
226
N05CF02
ATC
zolpidem; oral
2.7
18.5
113
473
N05AX12
ATC
aripiprazole; systemic
4.3
18.4
49
121
R02
ICPC
Shortness of breath/dyspnoea
2.9
18.4
96
369
F43.1
ICD-10 Finland
Post-traumatic stress disorder
5.5
18.2
36
69
A04
ICPC
Weakness/tiredness general
2.7
18.1
113
478
H03AA01
ATC
levothyroxine sodium; systemic
2.4
17.7
154
763
N06AB05
ATC
paroxetine; oral
3.9
17.7
54
148
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
5.2
17.6
37
75
M54.5
ICD-10 Finland
Low back pain
2.2
17.5
234
1386
N03AX12
ATC
[U] gabapentin; oral
2.6
17.3
116
508
J45.9
ICD-10 Finland
Asthma, unspecified
2.5
17.0
130
605
L03
ICPC
Low back symptom/complaint
2.3
17.0
190
1045
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
16.8
276
1765
N05CF01
ATC
zopiclone; oral
2.3
16.8
174
927
F31.8
ICD-10 Finland
Other bipolar affective disorders
6.2
16.7
29
49
G47.2
ICD-10 Finland
Disorders of the sleep-wake schedule
93.0
16.7
18
*
R03AC02
ATC
salbutamol; inhalant
2.2
16.6
340
2360
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
5.4
16.5
33
64
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
4.7
16.4
39
88
J45
ICD-10 Finland
Asthma
3.0
16.1
78
287
R07.4
ICD-10 Finland
Chest pain, unspecified
2.2
16.1
172
926
P76
ICPC
Depressive disorder
3.2
15.5
66
225
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
15.4
232
1422
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.9
15.4
81
312
F41.1
ICD-10 Finland
Generalized anxiety disorder
3.6
15.3
53
158
J45.1
ICD-10 Finland
Nonallergic asthma
3.4
15.2
57
179
R03DC03
ATC
montelukast; oral
2.4
15.0
117
548
L28
ICPC
Limited function/disability (L)
2.5
14.7
106
478
R51.80
ICD-10 Finland
Headache
2.4
14.7
119
566
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
5.6
14.6
28
52
A02BC05
ATC
esomeprazole; systemic
2.0
14.6
238
1496
C07AA05
ATC
propranolol; systemic
2.3
14.5
137
697
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.8
14.3
80
317
F32.1
ICD-10 Finland
Moderate depressive episode
3.3
14.2
57
187
F60.5
ICD-10 Finland
Anankastic personality disorder
12.4
14.2
25
21
XA420
NOMESCO Finland
Extensive sleep examination
12.4
14.2
25
21
N05CD07
ATC
temazepam; oral
3.1
14.1
61
210
P01
ICPC
Feeling anxious/nervous/tense
2.5
14.0
99
441
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.1
14.0
169
947
M79.7
ICD-10 Finland
Fibromyalgia
4.9
13.9
31
66
E66.01
ICD-10 Finland
Obesity due to excess calories
2.8
13.9
79
316
H02AB06
ATC
prednisolone; systemic
2.0
13.8
276
1852
N06AX18
ATC
reboxetine; oral
14.1
13.8
23
17
Z2445
NOMESCO Finland
Psychologist
3.9
13.7
42
115
R96
ICPC
Asthma
2.9
13.6
71
271
AA1AD
NOMESCO Finland
CT of head and brain
2.1
13.6
161
893
SPAT1240
SPAT
Therapeutic discussion
2.7
13.5
77
308
214
Kela drug reimbursment
Severe and chronic narcolepsy
143.4
13.5
14
*
E66.8
ICD-10 Finland
Other obesity
3.4
13.5
50
156
R03BB04
ATC
tiotropium bromide; inhalant
3.0
13.4
64
233
F33
ICD-10 Finland
Recurrent depressive disorder
5.5
13.4
26
49
N05BA01
ATC
diazepam; systemic, rectal
2.6
13.2
83
349
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.3
13.1
122
614
N02AX02
ATC
tramadol; systemic, rectal
2.0
13.1
244
1591
N05AN01
ATC
lithium; oral
5.2
13.0
27
54
F40.1
ICD-10 Finland
Social phobias
4.9
13.0
29
62
N05AA02
ATC
levomepromazine; systemic
4.4
12.9
33
79
A02BC03
ATC
lansoprazole; oral
2.1
12.7
162
921
A02BC01
ATC
omeprazole; systemic
2.1
12.5
160
911
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
12.4
164
945
N03AE01
ATC
clonazepam; systemic
3.6
12.3
41
119
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
6.2
12.2
21
35
N03AG01
ATC
valproic acid; systemic, rectal
3.2
12.1
51
172
L01
ICPC
Neck symptom/complaint
2.3
12.1
107
525
G47.8
ICD-10 Finland
Other sleep disorders
5.4
12.1
24
46
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
3.9
12.0
36
97
IDY03
NOMESCO Finland
Systematic individual therapy, cognitive-behavioural
4.1
12.0
34
88
R01AD09
ATC
mometasone; nasal
1.9
11.9
277
1926
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.6
11.8
39
113
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
11.7
254
1724
R03CA02
ATC
ephedrine; oral
66.4
11.6
13
*
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
4.0
11.6
34
90
EB1MA
NOMESCO Finland
Cephalometry with X-ray
5.4
11.6
23
44
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
11.6
74
313
N05BA12
ATC
alprazolam; oral
2.8
11.6
63
246
A02BC02
ATC
pantoprazole; systemic
1.9
11.5
373
2870
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
11.2
202
1286
-, ,
ICD-10 Finland
5.4
11.1
22
42
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.8
11.0
59
228
C07AB07
ATC
bisoprolol; oral
1.8
10.9
241
1636
N05AH03
ATC
olanzapine; systemic
3.0
10.9
50
178
C03DA01
ATC
spironolactone; oral
2.5
10.8
72
311
F90.0
ICD-10 Finland
Disturbance of activity and attention
3.4
10.7
39
120
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.6
10.7
69
293
DJD20
NOMESCO Finland
Plastic repair of septum of nose
3.8
10.7
33
91
J01AA02
ATC
doxycycline; systemic
2.0
10.7
422
3424
R03BA05
ATC
fluticasone; inhalant
2.1
10.7
116
617
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
5.4
10.7
21
40
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.6
10.6
25
56
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.6
10.5
63
258
R42
ICD-10 Finland
Dizziness and giddiness
2.1
10.5
125
688
A02BA02
ATC
ranitidine; systemic
2.2
10.5
100
505
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
10.5
92
449
R05FA02
ATC
opium derivatives and expectorants; systemic
1.8
10.5
214
1412
R01AD08
ATC
fluticasone; nasal
1.9
10.5
172
1059
SPAT1263
SPAT
Sampling
1.8
10.4
236
1606
R35
ICD-10 Finland
Polyuria
2.9
10.4
50
182
R03BA01
ATC
beclometasone; inhalant
2.3
10.4
83
389
M79.6
ICD-10 Finland
Pain in limb
1.8
10.4
252
1752
M03BX02
ATC
tizanidine; oral
1.8
10.3
352
2707
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.4
10.2
37
114
ZY010
NOMESCO Finland
Hospital outpatient
3.0
10.1
47
168
N04BD01
ATC
selegiline; oral
10.3
10.1
19
19
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
10.0
244
1694
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
10.0
310
2309
C09CA06
ATC
candesartan; oral
2.0
9.9
141
825
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
4.7
9.9
23
51
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
4.8
9.8
22
47
N06AX17
ATC
milnacipran; oral
10.9
9.8
18
17
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.6
9.8
57
230
N05AX08
ATC
risperidone; systemic
2.7
9.8
54
212
R03BA08
ATC
ciclesonide; inhalant
2.6
9.8
62
261
F51.9
ICD-10 Finland
Nonorganic sleep disorder, unspecified
7.6
9.8
22
30
IAB13
NOMESCO Finland
Psychiatric sleep disorder consultation
56.0
9.7
11
*
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
4.6
9.6
23
52
F43.00
ICD-10 Finland
Acute stress reaction mild
4.7
9.6
22
48
F33.1
ICD-10 Finland
Recurrent depressive disorder, current episode moderate
3.8
9.6
29
79
WX780
NOMESCO Finland
Remote monitoring CPAP
3.3
9.5
36
114
WX722
NOMESCO Finland
PEEP
3.3
9.5
36
114
E66.00
ICD-10 Finland
Metabolic syndrome
3.0
9.5
43
152
J34.2
ICD-10 Finland
Deviated nasal septum
3.0
9.5
43
152
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
3.9
9.4
28
75
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
4.8
9.4
21
45
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.7
9.4
52
205
R51
ICD-10 Finland
Headache
2.9
9.3
44
159
F32
ICD-10 Finland
Depressive episode
3.1
9.3
40
137
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
9.2
112
618
L08
ICPC
Shoulder symptom/complaint
1.9
9.2
135
795
SPAT1058
SPAT
PEF monitoring instruction
2.7
9.2
51
201
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.3
9.2
73
341
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
5.1
9.2
19
38
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.9
9.1
43
155
N02BF01
ATC
gabapentin; oral
2.4
9.1
67
303
C03CA01
ATC
furosemide; systemic
1.9
9.1
128
745
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
9.0
218
1498
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
9.0
112
624
SPAT1301
SPAT
No procedures
1.8
8.8
168
1074
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
8.8
183
1202
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.4
8.8
62
275
SAA01
NOMESCO Finland
Simple examination of mouth
1.9
8.7
417
3457
H02AB09
ATC
hydrocortisone; systemic
4.5
8.7
21
48
R06AE07
ATC
cetirizine; oral
1.7
8.7
246
1762
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.9
8.7
42
154
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
7.1
8.6
20
29
R03DA04
ATC
theophylline; systemic, rectal
3.4
8.6
31
95
WX110
NOMESCO Finland
Infiltration anesthesia
1.8
8.6
409
3378
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.7
8.6
315
2417
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
4.3
8.5
22
53
J02AC01
ATC
fluconazole; systemic
1.7
8.5
223
1560
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
8.5
58
253
F51
ICD-10 Finland
Nonorganic sleep disorders
3.6
8.5
28
81
G04BD04
ATC
oxybutynin; oral, transdermal
3.0
8.4
37
128
IEY18
NOMESCO Finland
Psychiatric sleep coaching, individual
91.4
8.4
9
*
XKD00
NOMESCO Finland
Uroflowmetry
2.2
8.4
79
395
F41.00
ICD-10 Finland
Moderate panic disorder
5.0
8.4
18
37
N06AB08
ATC
fluvoxamine; oral
4.1
8.4
23
58
N02BE01
ATC
paracetamol; systemic, rectal
2.3
8.4
488
4288
SPAT1307
SPAT
Psychosocial counselling and guidance
2.7
8.4
47
186
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.7
8.4
26
72
J01FA06
ATC
roxithromycin; oral
1.7
8.4
213
1477
M48.0
ICD-10 Finland
Spinal stenosis
2.4
8.3
62
281
Z02.7
ICD-10 Finland
Issue of medical certificate
2.6
8.3
50
205
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.9
8.3
40
146
Z2446
NOMESCO Finland
Social worker
2.6
8.3
48
193
Z3231
NOMESCO Finland
Registered nurse
1.8
8.3
150
942
K59.0
ICD-10 Finland
Constipation
3.1
8.2
35
119
R01AD01
ATC
beclometasone; nasal
2.0
8.2
93
500
R60.0
ICD-10 Finland
Localized oedema
2.2
8.2
70
337
SPAT1312
SPAT
General health counselling
1.8
8.2
177
1172
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
8.1
140
865
J31.0
ICD-10 Finland
Chronic rhinitis
2.4
8.1
60
271
M01AE02
ATC
naproxen; oral, rectal
1.7
8.1
320
2487
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
8.1
111
637
H02AB04
ATC
methylprednisolone; systemic
2.1
8.1
81
415
Z71.8
ICD-10 Finland
Other specified counselling
1.7
8.1
201
1381
G93.3
ICD-10 Finland
Postviral fatigue syndrome
17.5
8.1
12
7
R06AX22
ATC
ebastine; oral
2.0
8.1
104
584
SBB10
NOMESCO Finland
Dental impressions
2.5
8.1
50
208
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
8.1
141
875
Z00.0
ICD-10 Finland
General medical examination
1.9
8.0
112
647
J01DA01
ATC
[U] cefalexin
1.7
8.0
334
2632
XG466
NOMESCO Finland
Sleep oxymetry
4.1
8.0
22
56
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
8.0
62
287
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.8
7.9
39
144
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.2
7.9
67
321
E66.9
ICD-10 Finland
Obesity, unspecified
3.3
7.9
29
90
N05AF03
ATC
chlorprothixene; systemic
4.2
7.9
21
52
R06AX27
ATC
desloratadine; oral
1.7
7.9
173
1148
3472A
ICD-9 Finland
Cataplexy and narcolepsy[OBSTRUKTIIVINEN UNIAPNEA]
8.6
7.9
16
19
M03BC01
ATC
orphenadrine (citrate); systemic
1.8
7.9
132
809
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
3.8
7.8
24
66
C07AB02
ATC
metoprolol; systemic
2.0
7.8
86
457
D07AB02
ATC
hydrocortisone butyrate; topical
1.7
7.8
166
1091
AA40B, ,
NOMESCO Finland
15.3
7.7
12
8
282
Kela drug reimbursment
Sodium oxybat
45.6
7.7
9
*
J01FF01
ATC
clindamycin; systemic
1.8
7.7
147
935
E03
ICD-10 Finland
Other hypothyroidism
2.7
7.7
42
164
J01DB01
ATC
cefalexin; oral
1.9
7.7
455
3931
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
3.0
7.7
33
113
R55
ICD-10 Finland
Syncope and collapse
2.3
7.7
58
265
IGY02
NOMESCO Finland
Psychiatric monitoring contact
3.4
7.6
27
82
IHZ05, ,
SPAT
2.9
7.6
35
125
R03AC12
ATC
salmeterol; inhalant
3.2
7.5
29
93
G44.2
ICD-10 Finland
Tension-type headache
2.0
7.5
85
456
UJF32
NOMESCO Finland
Coloscopy
1.8
7.5
133
828
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.1
7.5
75
385
SAA03
NOMESCO Finland
Extended examination of mouth
1.7
7.4
228
1648
A03FA02
ATC
cisapride; oral, rectal
2.7
7.4
41
161
N07XX04
ATC
sodium oxybate; oral
81.2
7.4
8
*
WZC00
NOMESCO Finland
Treatment plan or consultation
1.7
7.4
210
1487
M03BC51
ATC
orphenadrine, combinations; systemic
1.7
7.4
153
995
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.4
7.4
52
230
C08DB01
ATC
diltiazem; oral
3.7
7.4
23
64
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
7.4
57
263
G04BD07
ATC
tolterodine; oral
3.3
7.3
27
84
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
4.2
7.3
19
46
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
2.1
7.3
72
367
WX723
NOMESCO Finland
CPAP therapy
3.0
7.3
32
111
D07AC01
ATC
betamethasone; topical
1.7
7.3
195
1360
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.0
7.3
80
425
R05
ICD-10 Finland
Cough
1.8
7.2
124
763
SFA30
NOMESCO Finland
Three-surface restoration
1.6
7.2
234
1713
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.2
7.2
64
313
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.4
7.2
26
80
R11
ICD-10 Finland
Nausea and vomiting
2.3
7.2
54
246
N06AA04
ATC
clomipramine; systemic
6.7
7.2
17
26
H53.1
ICD-10 Finland
Subjective visual disturbances
2.5
7.1
46
196
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.4
7.0
25
76
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
3.5
7.0
24
71
N05BE01
ATC
buspirone; oral
3.5
7.0
24
71
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
7.0
78
415
IGY99
NOMESCO Finland
Other psychiatric treatment contact
4.0
7.0
20
52
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.9
7.0
33
119
M01AH01
ATC
celecoxib; oral
1.9
6.9
90
506
R13
ICD-10 Finland
Dysphagia
2.4
6.9
46
198
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.3
6.9
54
250
A01
ICPC
Pain general/multiple sites
2.2
6.9
60
291
M01AH02
ATC
rofecoxib; oral
2.1
6.9
65
326
UKC02
NOMESCO Finland
Cystoscopy
2.0
6.8
76
406
L17
ICPC
Foot/toe symptom/complaint
1.7
6.7
168
1146
Z3226
NOMESCO Finland
Physiotherapist
1.9
6.7
96
557
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.0
6.7
75
400
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
6.7
83
459
R06AE09
ATC
levocetirizine; oral
1.9
6.7
86
482
M25.5
ICD-10 Finland
Pain in joint
1.6
6.7
185
1297
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
6.6
257
1952
R03AK03
ATC
[U] fenoterol and ipratropium bromide
3.1
6.6
28
95
R03AK07
ATC
formoterol and budesonide; inhalant
1.8
6.6
122
765
M54.4
ICD-10 Finland
Lumbago with sciatica
1.8
6.6
102
606
SCA01
NOMESCO Finland
Preventive oral health care, short
1.7
6.6
171
1176
A02BC04
ATC
rabeprazole; oral
2.2
6.6
55
262
SFA40
NOMESCO Finland
Restoration involving the entire crown of the tooth
1.8
6.6
121
758
L20
ICPC
Joint symptom/complaint NOS
3.0
6.6
29
101
J01FA10
ATC
azithromycin; systemic
1.6
6.6
323
2594
P20
ICPC
Memory disturbance
2.2
6.5
56
270
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
6.3
6.5
16
26
A06AD11
ATC
lactulose; oral
2.1
6.5
68
354
K59.1
ICD-10 Finland
Functional diarrhoea
2.7
6.5
35
136
K11.2
ICD-10 Finland
Sialoadenitis
3.6
6.5
21
60
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
6.5
203
1464
WZA90
NOMESCO Finland
Other medical or dental certificate
1.7
6.4
137
894
F41.8
ICD-10 Finland
Other specified anxiety disorders
3.1
6.4
26
86
P74
ICPC
Anxiety disorder/anxiety state
2.7
6.4
34
131
SPAT1360
SPAT
Extensive global examination
2.6
6.4
37
149
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.0
6.4
76
414
R03BA02
ATC
budesonide; inhalant
1.8
6.4
101
605
R04.2
ICD-10 Finland
Haemoptysis
3.7
6.4
20
56
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.0
6.4
27
92
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
6.1
6.3
16
27
SPAT1310
SPAT
Counselling related to known health issue
1.6
6.3
169
1170
R03AK08
ATC
formoterol and beclometasone; inhalant
2.9
6.3
30
109
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
9.4
6.3
12
13
F84.5
ICD-10 Finland
Asperger syndrome
9.4
6.3
12
13
QBJ30
NOMESCO Finland
Correction of abdominal apron
9.4
6.3
12
13
N02BF02
ATC
pregabalin; oral
2.5
6.3
41
175
R4110, ,
SPAT
2.0
6.3
71
380
R00.2
ICD-10 Finland
Palpitations
2.2
6.3
52
247
R01AD05
ATC
budesonide; nasal
2.3
6.3
49
227
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
2.5
6.3
38
157
T82
ICPC
Obesity
2.7
6.2
34
133
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
6.2
100
601
SPE02
NOMESCO Finland
Metal-framed partial denture
5.1
6.2
18
36
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
5.1
6.2
18
36
P58
ICPC
Psychological, Therapeutic counselling/listening
4.0
6.2
17
43
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.0
6.2
67
353
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
6.4
6.2
15
24
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.5
6.2
39
164
R52.9
ICD-10 Finland
Pain, unspecified
2.1
6.2
61
311
M01AB05
ATC
diclofenac; systemic, rectal
1.6
6.1
349
2878
R52.2
ICD-10 Finland
Other chronic pain
3.0
6.1
27
94
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.1
6.1
63
326
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
4.2
6.1
16
39
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.7
6.1
135
889
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.0
6.1
72
392
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.0
6.1
72
392
N06BA12
ATC
lisdexamfetamine; oral
5.7
6.0
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
58
121
5.24
26.85
1.2
1.2
419.41
461.24
mg/l
0.42
58
112
126
469
3.19
26.12
2.3
2.2
338.68
371.03
nmol/l
1.24
119
442
317
1914
2.56
25.29
2.4
2.0
101.47
96.29
pmol/l
1.12
194
1024
341
2163
2.53
23.98
7.8
7.9
1.21
1.21
mmol/l
0.39
288
1888
251
1399
2.47
23.25
4.5
3.6
0.00
0.01
estimate
0.96
86
507
482
3701
3.51
22.12
6.5
4.3
14.64
14.60
pmol/l
0.15
459
3415
50
109
4.95
21.94
1.2
1.2
33.14
1191.49
e6/l
0.62
44
90
48
107
4.82
20.50
1.2
1.2
2.70
13.51
e6/l
0.95
40
84
303
1932
2.27
19.50
4.8
5.3
36.32
36.23
g/l
0.11
290
1817
455
3472
2.83
19.31
5.3
4.3
11.16
10.42
mm/h
0.56
436
3263
253
1503
2.27
19.27
2.8
3.4
2.35
2.35
mmol/l
0.10
234
1378
303
1944
2.25
19.05
7.3
7.1
1.21
1.21
mmol/l
0.20
281
1801
235
1363
2.27
18.87
2.7
2.1
128.20
239.66
u/l
1.57
220
1301
353
2421
2.29
18.72
4.0
3.0
114.21
109.69
ug/l
0.11
338
2276
169
856
2.41
18.58
1.7
1.7
447.75
19479164.43
pmol/l
0.80
137
729
138
640
2.55
18.34
1.9
1.7
1415.75
1168.65
nmol/l
1.77
111
489
83
298
3.10
17.91
4.4
3.8
4.32
4.67
pmol/l
2.45
67
273
113
485
2.68
17.53
7.5
6.1
—
—
—
0
0
206
1160
2.24
17.49
2.7
2.1
3.01
2.85
mg/l
0.29
191
1008
358
2523
2.21
17.00
4.5
3.5
0.00
0.00
estimate
-0.00
93
535
245
1504
2.14
16.50
2.7
2.7
55.28
62.43
u/l
1.15
228
1407
358
2545
2.17
16.32
4.6
3.6
0.00
3.00
estimate
0.50
94
542
141
702
2.36
15.80
2.3
2.4
2.46
2.35
g/l
1.53
129
649
357
2562
2.13
15.51
4.6
3.6
0.00
0.03
estimate
1.32
87
506
146
760
2.26
14.61
2.3
2.4
13.76
13.72
umol/l
0.02
134
708
23
35
6.82
14.58
1.1
1.0
—
—
—
0
0
373
2755
2.11
14.57
9.6
10.1
3.92
4.05
e9/l
0.68
340
2416
306
2104
2.03
14.57
2.8
2.4
77.48
75.76
nmol/l
0.48
291
1918
448
3589
2.36
13.76
8.2
8.4
76.42
78.44
u/l
0.52
428
3402
254
1662
1.98
13.64
4.4
3.5
330.34
35.30
ng/l
0.52
164
1108
204
1236
2.04
13.62
1.7
1.6
18.65
20.52
nmol/l
1.06
186
1060
513
4402
3.59
13.48
8.1
5.1
1.65
1.86
mu/l
5.11
487
4102
128
651
2.26
13.43
2.4
2.4
22.96
23.47
%
0.18
117
610
205
1250
2.02
13.40
1.5
1.3
1.34
1.81
u/ml
0.34
65
357
150
816
2.15
13.31
2.6
2.6
2.43
2.44
mmol/l
0.36
139
739
282
1951
1.92
12.49
4.5
3.4
0.00
0.01
estimate
0.96
75
455
76
318
2.61
12.20
2.6
2.3
4.11
7.86
ug/l
2.34
61
285
390
3033
1.99
11.85
5.5
4.2
52.50
942.41
e6/l
—
8
46
151
858
2.05
11.76
1.5
1.3
4.84
10.80
u/ml
0.97
67
350
161
947
1.99
11.33
1.5
1.3
21.46
30.61
iu/ml
0.99
48
281
189
1192
1.89
10.72
4.0
3.3
976.28
982.73
ng/l
0.01
160
1006
76
339
2.44
10.63
2.7
2.4
9.87
13.63
au/ml
—
7
33
351
2697
1.84
10.32
6.3
5.3
6.88
6.59
mmol/l
0.32
337
2516
118
641
2.07
10.24
2.3
1.8
1.58
1.44
%
1.47
108
568
511
4503
3.00
10.24
6.1
4.7
5.97
5.88
mmol/l
0.78
477
4182
52
197
2.81
10.09
1.4
1.2
0.96
2.09
u/ml
—
5
14
231
1577
1.80
10.00
4.2
3.4
8.03
8.16
mmol/l
0.13
198
1342
500
4374
2.63
9.88
7.8
5.9
38.78
38.82
mmol/mol
0.03
465
4138
164
1014
1.88
9.73
2.8
2.5
7.27
6.25
e6/l
0.28
151
908
62
262
2.54
9.71
2.8
3.2
1.70
2.19
mmol/l
0.44
44
195
325
2470
1.78
9.60
5.8
7.1
9.67
11.34
umol/l
3.84
309
2364
109
590
2.06
9.50
4.9
6.2
1.04
1.03
mmol/l
0.05
102
544
174
1119
1.81
8.99
4.9
3.5
1.02
1.02
kg/l
0.20
118
741
52
210
2.63
8.93
1.3
1.5
444.94
300.00
mu/l
0.65
47
192
184
1209
1.79
8.82
2.5
2.9
348.63
336.06
umol/l
0.81
161
1077
522
4720
3.23
8.65
20.1
14.1
19.26
22.81
mg/l
1.93
441
3794
523
4736
3.29
8.61
23.8
16.2
139.65
139.67
mmol/l
0.10
513
4641
523
4740
3.27
8.51
23.9
16.3
3.97
3.95
mmol/l
0.88
512
4633
270
1991
1.70
8.49
14.4
11.1
1.21
1.17
inr
0.75
229
1651
167
1077
1.79
8.47
1.9
1.8
0.90
1.18
mg/l
0.88
122
818
20
32
6.44
8.08
1.4
1.2
0.48
0.52
ratio
0.75
14
20
114
666
1.90
7.88
2.2
2.5
139.81
121.67
ug/g
0.24
91
519
21
52
4.16
7.87
1.2
1.1
—
—
—
0
0
186
1260
1.72
7.85
3.5
2.9
0.34
0.42
e6/l
0.31
150
912
21
53
4.08
7.68
1.1
1.1
—
—
—
0
0
65
312
2.23
7.65
2.8
3.8
70.48
78.02
ng/l
0.43
57
278
71
355
2.15
7.56
1.3
1.2
195.40
295.57
u/ml
0.50
66
325
124
761
1.81
7.30
2.9
3.8
0.83
0.82
mmol/l
0.32
116
730
50
224
2.36
6.91
2.6
2.0
4.74
9.07
iu/ml
0.69
16
53
206
1475
1.64
6.85
3.8
3.1
47.86
95.10
e6/l
0.49
171
1116
67
343
2.09
6.70
1.6
1.5
—
—
—
0
0
405
3439
1.68
6.54
4.1
3.3
42.09
46.24
u/l
0.66
384
3284
230
1707
1.60
6.52
3.4
3.6
54.97
32.64
u/l
0.41
218
1624
163
1111
1.66
6.52
1.5
1.5
2.38
2.40
g/l
0.03
102
712
36
144
2.61
6.33
1.6
1.3
4.59
9.54
u/ml
—
8
26
533
4992
3.47
6.01
14.4
11.6
34.99
26.85
u/l
0.74
519
4867
62
325
2.02
5.82
3.0
4.3
1.23
1.23
mmol/l
0.00
50
286
69
382
1.92
5.55
1.3
1.2
116.98
159.41
u/ml
0.40
21
160
197
1458
1.55
5.42
5.1
4.3
8.04
8.64
mg/mmol
0.08
130
911
66
363
1.93
5.41
3.7
3.1
4.27
4.51
kpa
0.58
66
352
16
44
3.72
5.24
1.1
1.0
—
—
—
0
0
496
4546
1.96
5.16
18.4
13.3
85.80
86.33
ml/min/173m2
0.22
467
4161
193
1444
1.52
4.97
3.3
3.0
0.00
0.00
estimate
0.80
75
428
32
137
2.42
4.92
1.5
1.4
268.04
310.13
ug/g
0.40
17
82
50
258
2.03
4.91
2.2
3.1
114.65
165.28
ng/l
0.78
43
231
46
230
2.09
4.91
3.1
2.6
1.19
1.24
%
0.14
46
230
530
5003
2.81
4.82
25.7
17.9
77.79
74.50
umol/l
1.48
523
4945
37
177
2.17
4.43
1.9
1.6
—
—
—
0
0
71
426
1.77
4.43
4.1
3.6
6.11
5.76
kpa
2.03
71
414
44
228
2.01
4.29
3.2
2.6
0.70
0.62
%
0.74
44
228
43
221
2.03
4.29
1.6
1.8
2.84
3.55
mg/l
0.37
34
163
484
4456
1.74
4.21
5.0
4.1
1.38
1.27
mmol/l
2.32
450
4159
45
237
1.98
4.20
2.7
1.6
0.16
0.27
mg/l
1.35
17
102
67
403
1.75
4.15
4.1
3.7
3.10
1.78
mmol/l
2.41
60
351
10
17
5.97
4.14
1.9
1.6
74.09
81.78
ng/l
—
10
17
50
275
1.90
4.12
2.9
2.2
713.06
7042.33
u/l
2.35
15
122
51
284
1.88
4.05
14.7
12.6
94.71
94.14
%
0.71
51
284
81
517
1.67
4.05
1.8
1.9
—
—
—
0
0
13
31
4.27
4.03
1.1
1.1
32.76
38.27
ng/l
—
5
19
13
31
4.27
4.03
1.1
1.0
298.33
267.40
ng/l
—
6
20
13
31
4.27
4.03
1.1
1.0
1036.00
671.75
ng/l
—
6
20
104
709
1.58
3.98
2.1
2.0
—
—
—
0
0
503
4698
1.86
3.95
5.9
4.9
4.56
4.66
mmol/l
1.44
468
4428
77
490
1.66
3.89
1.9
2.0
—
—
—
0
0
501
4678
1.83
3.88
5.8
4.8
1.39
1.46
mmol/l
3.52
464
4386
506
4742
1.87
3.83
6.6
5.4
2.70
2.75
mmol/l
0.75
471
4453
35
176
2.06
3.73
1.5
1.6
15.60
7.62
u/ml
—
5
44
272
2264
1.40
3.70
2.8
2.9
—
—
estimate
—
0
0
54
316
1.79
3.68
1.4
1.7
—
—
—
0
0
154
1162
1.45
3.62
3.8
4.1
93.57
91.89
%
0.36
148
1139
74
486
1.60
3.31
11.1
10.4
1.66
0.91
mmol/l
1.01
62
405
49
290
1.76
3.23
1.7
1.3
17.16
26.92
iu/l
1.75
44
251
11
29
3.85
3.20
1.0
1.1
—
—
—
0
0
26
124
2.15
3.19
1.3
1.1
—
—
—
0
0
34
182
1.93
3.08
2.2
1.8
42.71
40.10
nmol/l
0.22
34
174
29
147
2.03
3.06
1.7
2.2
1.57
5.13
iu/l
3.42
13
66
109
795
1.46
3.02
4.0
3.5
165.73
440.77
ng/l
1.36
80
578
14
51
2.79
3.00
1.6
1.3
—
—
—
0
0
43
254
1.75
2.87
6.4
8.2
25.73
24.76
mmol/l
0.98
43
241
25
124
2.06
2.80
1.7
1.2
—
—
—
0
0
25
124
2.06
2.80
1.3
1.1
—
—
—
0
0
21
97
2.21
2.80
1.7
1.5
—
—
—
0
0
8
18
4.49
2.80
1.4
1.4
—
—
—
0
0
369
3307
1.35
2.79
3.1
3.3
—
—
—
0
0
63
421
1.56
2.64
12.2
11.4
126.03
121.48
g/l
0.99
63
413
105
780
1.43
2.63
2.1
2.1
—
—
—
0
0
12
41
2.97
2.63
1.1
1.2
—
—
—
0
0
53
341
1.61
2.60
2.4
2.5
62.54
70.36
ml/min/173m2
0.98
24
147
7
15
4.71
2.60
1.0
1.2
—
—
—
0
0
7
15
4.71
2.60
1.0
1.3
—
—
—
0
0
26
137
1.94
2.50
1.3
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
116
2.03
2.49
2.8
2.6
0.42
0.31
iu/ml
0.34
12
60
7
16
4.42
2.48
1.0
1.3
—
—
—
0
0
14
57
2.49
2.46
2.7
1.9
—
—
—
0
0
64
439
1.52
2.40
1.6
2.6
0.22
0.22
g/l
0.06
55
416
28
154
1.86
2.38
2.3
2.8
—
—
—
0
0
19
91
2.13
2.35
1.2
1.1
—
—
—
0
0
102
773
1.39
2.28
3.4
2.7
0.96
1.01
e6/l
0.10
57
410
536
5210
2.31
2.27
32.1
21.7
259.32
252.28
e9/l
1.69
527
5119
536
5212
2.30
2.24
31.9
21.6
90.74
90.65
fl
0.20
528
5165
9
29
3.14
2.23
1.1
1.1
1804.22
1663.86
miu/ml
—
9
29
9
29
3.14
2.23
1.3
1.7
—
19.40
—
0
5
536
5213
2.29
2.22
33.1
22.2
40.81
40.70
%
0.20
528
5161
536
5213
2.29
2.22
32.0
21.6
4.54
4.54
e12/l
0.05
526
5110
10
35
2.89
2.22
5.2
2.9
12.16
19.05
mu/l
—
10
35
536
5216
2.26
2.16
32.2
21.8
136.59
136.38
g/l
0.13
528
5167
435
4059
1.35
2.12
22.4
17.6
13.55
13.51
%
0.31
429
4011
5
10
5.03
2.07
1.0
1.1
—
—
—
0
0
5
10
5.03
2.07
1.0
1.1
—
—
—
0
0
5
10
5.03
2.07
1.0
1.3
—
—
—
0
0
5
10
5.03
2.07
1.2
1.1
97.00
110.20
%
—
5
10
23
125
1.88
2.05
1.6
1.6
—
—
—
0
0
6
15
4.03
2.04
1.0
1.1
—
—
—
0
0
6
15
4.03
2.04
1.0
1.3
—
—
—
0
0
14
63
2.25
2.02
2.1
1.5
308.86
381.63
pmol/l
0.46
14
54
10
38
2.66
2.01
1.7
1.8
—
—
—
0
0
7
21
3.36
1.97
1.1
1.2
—
—
—
0
0
60
426
1.46
1.93
3.8
3.0
—
—
—
0
0
29
174
1.70
1.90
1.3
1.7
—
—
—
0
0
93
718
1.36
1.86
2.0
2.0
—
—
—
0
0
31
191
1.66
1.85
3.9
3.5
25.26
25.39
mmol/l
0.09
31
185
232
2023
1.25
1.85
1.9
1.9
1.54
1.34
mmol/l
2.24
189
1745
107
846
1.33
1.83
1.5
1.5
—
—
—
0
0
9
35
2.60
1.81
1.2
1.2
116.78
103.43
pmol/l
—
9
35
42
284
1.52
1.73
1.0
1.0
—
—
—
0
0
11
226
0.48
1.69
1.1
1.2
0.82
0.90
g/l
0.56
11
226
37
246
1.54
1.65
1.5
1.7
—
—
—
0
0
60
440
1.41
1.65
2.2
2.4
29.08
33.50
u/l
0.66
53
375
170
1448
1.25
1.63
5.2
5.1
1.87
2.27
ug/l
0.61
155
1311
5
14
3.59
1.62
1.2
1.1
—
—
—
0
0
139
1160
1.27
1.58
4.5
4.2
21.56
21.44
%
0.03
67
536
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
7
26
2.71
1.58
1.3
2.2
101.14
133.88
%
—
7
26
11
51
2.18
1.51
3.2
2.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
6
21
2.88
1.51
1.2
1.0
125.17
117.71
%
—
6
21
11
216
0.50
1.50
1.1
1.1
1.44
1.54
g/l
0.49
11
216
17
94
1.83
1.49
1.8
1.5
—
—
—
0
0
13
66
1.99
1.44
1.2
1.3
—
—
—
0
0
10
46
2.20
1.40
3.4
1.7
—
—
—
0
0
10
46
2.20
1.40
3.4
1.7
—
—
—
0
0
10
46
2.20
1.40
3.4
1.7
—
—
—
0
0
28
182
1.57
1.40
1.5
1.9
1.80
1.40
g/l
1.07
23
161
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
29
2.43
1.39
1.0
1.1
—
—
—
0
0
13
67
1.96
1.39
1.2
1.2
—
—
—
0
0
19
112
1.72
1.37
1.8
1.5
—
—
—
0
0
15
82
1.85
1.37
3.1
3.1
6.63
8.48
pmol/l
0.76
15
82
5
17
2.96
1.36
1.2
1.2
—
—
—
0
0
14
75
1.89
1.35
1.2
1.2
—
—
—
0
0
14
75
1.89
1.35
1.2
1.2
—
—
—
0
0
8
34
2.37
1.29
2.1
1.4
—
—
—
0
0
5
18
2.79
1.28
1.2
1.2
—
—
—
0
0
15
84
1.81
1.28
1.1
1.1
1.20
98.30
iu/ml
—
5
20
123
1043
1.23
1.21
1.8
1.6
—
—
—
0
0
8
38
2.12
1.19
1.3
3.7
92.00
99.84
%
—
8
38
10
50
2.02
1.17
1.8
1.7
—
—
—
0
0
7
31
2.27
1.10
1.3
1.4
—
80.00
—
0
6
7
31
2.27
1.10
2.4
1.3
—
—
—
0
0
7
31
2.27
1.10
2.4
1.3
—
—
—
0
0
18
112
1.63
1.10
1.3
1.3
—
—
—
0
0
36
266
1.38
1.01
1.3
1.4
—
—
—
0
0
19
123
1.56
1.01
1.2
1.2
205.22
254.14
u/ml
0.49
13
72
49
623
0.77
1.00
1.8
2.0
3.32
3.46
ratio
0.39
40
491
18
115
1.58
1.00
1.4
1.4
—
—
—
0
0
7
35
2.01
1.00
1.0
1.5
59.57
75.23
umol/l
—
7
35
13
76
1.73
0.99
2.9
1.9
—
—
—
0
0
62
499
1.27
0.98
4.3
4.9
236.50
248.48
u/l
0.45
56
477
18
116
1.57
0.97
1.2
1.1
3.92
2.65
u/ml
—
9
60
133
1162
1.19
0.97
2.3
2.4
—
—
—
0
0
6
27
2.24
0.93
1.0
1.2
113.67
195.51
iu/ml
—
6
27
102
875
1.20
0.91
3.0
3.1
0.82
0.74
ug/l
0.21
68
544
12
71
1.71
0.89
2.5
1.9
13.32
13.07
%
0.26
12
71
8
42
1.92
0.89
2.6
2.5
—
—
—
0
0
19
128
1.50
0.87
2.6
1.7
—
—
—
0
0
32
239
1.36
0.86
1.6
1.3
—
—
—
0
0
8
44
1.83
0.86
2.6
4.6
—
—
—
0
0
15
96
1.58
0.85
1.7
1.6
—
—
—
0
0
84
714
1.21
0.83
3.9
2.8
3.01
2.39
e6/l
0.18
40
351
13
81
1.62
0.82
3.1
1.5
—
—
—
0
0
68
567
1.23
0.81
4.9
4.4
30.45
31.64
%
0.42
47
391
25
181
1.40
0.81
1.6
1.4
—
—
—
0
0
8
47
1.71
0.81
14.0
13.2
651.75
839.53
nmol/l
—
8
47
34
438
0.76
0.79
3.4
4.7
5.33
32.94
ug/l
0.85
24
355
37
471
0.77
0.79
1.4
1.7
3.39
3.47
mmol/l
0.23
30
342
25
183
1.38
0.77
1.4
1.7
—
—
—
0
0
5
24
2.09
0.74
1.2
1.7
—
—
—
0
0
5
24
2.09
0.74
1.2
1.7
—
—
—
0
0
27
202
1.35
0.74
2.9
7.0
1.61
1.63
%
0.02
27
190
5
26
1.93
0.71
1.0
1.2
—
—
—
0
0
9
59
1.53
0.68
1.0
1.1
—
—
—
0
0
14
203
0.68
0.68
1.1
1.5
0.90
1.13
ratio
—
5
133
14
203
0.68
0.68
1.1
1.5
0.98
0.94
ratio
—
5
133
14
203
0.68
0.68
1.1
1.5
0.87
1.25
ratio
—
5
133
7
43
1.64
0.67
1.3
1.0
—
—
—
0
0
14
201
0.69
0.65
1.1
1.5
—
—
—
0
0
13
87
1.51
0.63
2.1
3.0
—
831.40
—
0
5
21
156
1.36
0.62
1.1
1.4
—
—
—
0
0
5
30
1.67
0.61
2.8
3.7
1333.40
793.90
mg
—
5
30
15
106
1.43
0.58
1.5
1.4
—
—
—
0
0
6
39
1.54
0.53
1.5
1.1
—
—
—
0
0
6
40
1.51
0.51
1.8
1.4
1.13
1.18
promille
—
6
33
6
40
1.51
0.51
1.5
1.2
—
—
—
0
0
11
75
1.48
0.51
1.6
1.7
—
—
—
0
0
16
118
1.37
0.50
1.7
1.6
51.24
49.98
ug/l
0.06
16
118
65
570
1.16
0.49
1.7
3.4
5.25
8.24
umol/l
2.56
51
514
12
85
1.42
0.47
1.2
1.1
1.13
2.29
eliau/ml
—
7
37
15
111
1.36
0.47
4.2
6.9
—
145.83
—
0
12
20
156
1.29
0.45
2.0
1.8
—
—
—
0
0
20
253
0.78
0.45
1.4
1.5
—
—
—
0
0
21
165
1.28
0.45
2.8
2.0
—
—
—
0
0
13
95
1.38
0.44
1.2
1.7
—
—
—
0
0
17
131
1.31
0.42
2.4
4.1
1.75
2.49
ratio
—
10
77
8
58
1.38
0.41
1.8
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
8
60
1.34
0.40
1.5
1.6
—
—
—
0
0
8
61
1.32
0.39
1.0
1.0
—
—
—
0
0
6
43
1.40
0.35
1.2
1.2
—
—
—
0
0
11
82
1.35
0.34
1.0
1.2
10.73
33.09
u/l
0.95
11
73
16
130
1.24
0.29
3.0
1.8
—
—
—
0
0
15
121
1.25
0.28
3.7
3.1
1.51
1.53
mmol/l
0.04
15
116
42
376
1.13
0.27
2.2
1.8
—
—
—
0
0
50
454
1.11
0.26
2.4
1.9
—
—
—
0
0
17
143
1.19
0.23
2.8
4.6
55.00
46.51
mg/l
0.30
12
123
17
143
1.19
0.23
2.8
4.6
33.23
46.85
mg/l
0.46
12
122
5
39
1.28
0.23
1.0
1.1
8.20
8.13
mm/h
—
5
39
18
153
1.18
0.22
3.8
3.3
1.41
1.42
mg/l
0.03
18
137
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
9.9
—
6.02
—
0
11
5
43
1.16
0.21
1.2
1.7
—
—
—
0
0
25
221
1.14
0.20
1.5
1.3
176.00
232.07
miu/ml
—
9
113
6
51
1.18
0.19
2.5
2.6
109.17
105.43
mmol/l
—
6
51
6
51
1.18
0.19
2.5
2.6
1.21
1.20
mmol/l
—
6
51
11
90
1.23
0.19
1.0
2.9
3.98
5.94
umol/l
—
5
68
7
63
1.11
0.17
1.0
1.2
—
—
—
0
0
15
171
0.87
0.15
1.7
1.7
—
—
—
0
0
7
88
0.79
0.14
3.6
4.5
60.60
467.77
u/ml
—
7
83
34
365
0.93
0.13
1.6
1.6
769.92
961.70
mu/l
1.10
29
305
16
145
1.11
0.09
1.9
1.8
—
—
—
0
0
6
57
1.05
0.08
1.0
1.3
—
—
—
0
0
7
65
1.08
0.08
1.1
1.2
—
—
—
0
0
8
74
1.08
0.07
1.6
3.4
16.50
21.93
u/ml
—
8
74
7
81
0.86
0.07
1.1
1.1
—
—
—
0
0
10
89
1.13
0.07
1.2
1.6
—
—
—
0
0
26
250
1.04
0.03
18.3
14.5
16.52
15.87
%
0.70
26
241
18
174
1.04
0.00
1.3
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.9
—
81.88
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
6
64
0.94
-0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.01
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
-0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
6
63
0.95
-0.00
1.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
11.3
—
10.62
—
0
9
6
62
0.97
-0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.00
—
0
5
6
64
0.94
-0.00
1.0
1.4
—
—
—
0
0
6
62
0.97
-0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
0.40
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint F5_HYPERSOMNIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_HYPERSOMNIA | 1.495 [1.17, 1.91] | 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.241 |
During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 1255 females with F5_HYPERSOMNIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_HYPERSOMNIA | 1.255 [1.08, 1.45] | 0.003 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 1339 males with F5_HYPERSOMNIA died.
Mortality risk
Mortality risk for people of age
years, who have F5_HYPERSOMNIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.177% | 0.207% |
| 5 | 0.948% | 1.378% |
| 10 | 2.469% | 3.501% |
| 15 | 4.569% | 6.807% |
| 20 | 7.849% | 11.469% |
Relationships between endpoints
↥Index endpoint: F5_HYPERSOMNIA – Hypersomnia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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