Premenstrual syndrome

N14_PREMENSTSYNDROM

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

None

313377

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N94.3
  • Hospital discharge: ICD-9 6254A
  • Cause of death: ICD-10 N94.3
  • Cause of death: ICD-9 6254A

2 out of 7 registries used, show all original rules.

704

4. Check minimum number of events

None

704

5. Include endpoints

None

704

6. Filter based on genotype QC (FinnGen only)

622

Control definitions (FinnGen only)

Control exclude
N14_FEMALEGENNONINF

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2345 2345 -
Only index persons 2313 2313 -
Unadjusted period prevalence (%)
Whole population 0.07 0.07 -
Only index persons 0.09 0.09 -
Median age at first event (years)
Whole population - 39.17 -
Only index persons - 39.11 -

-FinnGen-

Key figures

All Female Male
Number of individuals 622 622 -
Unadjusted period prevalence (%) 0.22 0.22 -
Median age at first event (years) 40.05 40.05 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
655
Matched controls
6550
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N94.3
ICD-10 Finland
Premenstrual tension syndrome
4792.9
307.7
634
41
N95.1
ICD-10 Finland
Menopausal and female climacteric states
+∞
172.8
158
*
LCA06
NOMESCO Finland
Biopsy of endometrium
15.9
129.7
119
90
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
7.5
99.9
170
293
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
13.4
95.9
96
83
N97.9
ICD-10 Finland
Female infertility, unspecified
28.6
87.8
60
23
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
4.4
77.7
358
1409
LC2HE
NOMESCO Finland
Hystero-salpingography with ultrasound
21.4
74.6
57
29
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
4.2
72.4
320
1209
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
9.8
70.5
87
101
N94.5
ICD-10 Finland
Secondary dysmenorrhoea
25.1
68.6
49
21
N06AB04
ATC
citalopram; systemic
4.2
63.2
238
790
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
5.8
57.3
117
235
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
4.9
55.4
142
348
TLC00
NOMESCO Finland
Insertion of intrauterine device
6.1
52.7
100
187
N06AB03
ATC
fluoxetine; oral
4.2
47.9
153
442
G03DB01
ATC
dydrogesterone; oral
3.8
45.7
175
573
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
4.4
45.5
131
349
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
3.1
42.8
274
1227
J02AC01
ATC
fluconazole; systemic
3.0
39.2
411
2375
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.9
38.9
340
1782
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
10.6
38.4
43
43
ULC02
NOMESCO Finland
Hysteroscopy
10.6
37.5
42
42
N06AB10
ATC
escitalopram; oral
2.9
37.2
252
1148
N84.0
ICD-10 Finland
Polyp of corpus uteri
72.6
36.4
41
6
N94.6
ICD-10 Finland
Dysmenorrhoea, unspecified
8.5
34.5
46
58
N92.4
ICD-10 Finland
Excessive bleeding in the premenopausal period
12.3
33.6
34
29
G03DA02
ATC
medroxyprogesterone; systemic
6.0
33.2
62
113
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
332.5
32.1
32
*
B02AA02
ATC
tranexamic acid; systemic
3.5
31.6
130
438
N06AX16
ATC
venlafaxine; oral
3.1
30.1
157
609
R53
ICD-10 Finland
Malaise and fatigue
2.6
28.9
232
1127
C07AA05
ATC
propranolol; systemic
2.7
28.7
203
926
N05BA04
ATC
oxazepam; oral
2.6
28.6
224
1075
A06AC01
ATC
ispaghula (psylla seeds); oral
2.9
27.4
165
690
A02BC05
ATC
esomeprazole; systemic
2.5
27.1
272
1461
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
282.1
26.9
27
*
N80.0
ICD-10 Finland
Endometriosis of uterus
62.7
26.2
30
5
M79.7
ICD-10 Finland
Fibromyalgia
5.5
25.9
52
101
LCA16
NOMESCO Finland
Destruction of endometrium
270.8
25.9
26
*
LCA13
NOMESCO Finland
Curettage of cervix and body of uterus
29.8
25.6
34
12
N95.2
ICD-10 Finland
Postmenopausal atrophic vaginitis
+∞
25.2
24
*
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
3.3
24.9
108
373
P03
ICPC
Feeling depressed
2.8
24.8
147
607
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.6
24.5
90
280
N94.4
ICD-10 Finland
Primary dysmenorrhoea
6.1
24.3
43
74
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
4.6
23.5
59
139
N80.9
ICD-10 Finland
Endometriosis, unspecified
37.8
23.2
29
8
N06AX21
ATC
duloxetine; oral
3.1
23.1
109
395
G03GA05
ATC
follitropin alfa; parenteral
7.7
23.1
33
45
P01
ICPC
Feeling anxious/nervous/tense
2.5
23.1
202
1006
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
5.4
22.4
46
91
N81.6
ICD-10 Finland
Rectocele
18.8
22.4
34
19
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.6
22.3
159
717
6254A
ICD-9 Finland
Pain and other symptoms associated with female genital organs, Premenstrual tension syndromes
+∞
22.0
21
*
Z30.2
ICD-10 Finland
Sterilization
3.0
22.0
111
418
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.8
21.8
127
517
LA2AE
NOMESCO Finland
Ultrasound examination of ovarian cyst
119.0
21.7
23
*
N06AX11
ATC
mirtazapine; oral
2.3
20.9
245
1374
N06AB05
ATC
paroxetine; oral
4.0
20.8
63
171
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
20.5
149
676
N06AX26
ATC
vortioxetine; oral
3.0
20.2
97
354
N92.5
ICD-10 Finland
Other specified irregular menstruation
3.7
20.2
69
204
G03GA01
ATC
chorionic gonadotrophin; parenteral
5.7
20.0
38
70
N97.4
ICD-10 Finland
Female infertility associated with male factors
+∞
19.9
19
*
N06AB06
ATC
sertraline; oral
2.7
19.8
129
554
LCD04
NOMESCO Finland
Laparoscopic hysterectomy
8.6
19.4
25
30
ULA02
NOMESCO Finland
Kolposcopy
3.0
19.1
91
330
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.5
19.1
152
718
N05AH04
ATC
quetiapine; oral
2.4
18.9
157
755
A02BC02
ATC
pantoprazole; systemic
2.1
18.9
419
2970
TLW00
NOMESCO Finland
Insemination
+∞
18.8
18
*
N95.0
ICD-10 Finland
Postmenopausal bleeding
14.7
18.7
31
22
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.1
18.7
266
1596
F41.1
ICD-10 Finland
Generalized anxiety disorder
3.0
18.5
92
342
N87.0
ICD-10 Finland
Mild cervical dysplasia
45.4
18.3
22
5
N02AX02
ATC
tramadol; systemic, rectal
2.2
18.3
225
1274
M03AX01
ATC
botulinum toxin; parenteral
5.8
17.9
33
59
LAA10
NOMESCO Finland
Percutaneous or transvaginal puncture and recovery of oocyte
68.6
17.8
20
*
N80.1
ICD-10 Finland
Endometriosis of ovary
68.6
17.8
20
*
N87.1
ICD-10 Finland
Moderate cervical dysplasia
+∞
17.8
17
*
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.4
17.7
145
691
M03BX02
ATC
tizanidine; oral
2.1
17.7
448
3301
A04
ICPC
Weakness/tiredness general
2.4
17.4
143
683
G44.2
ICD-10 Finland
Tension-type headache
2.4
17.1
134
625
TLC02
NOMESCO Finland
Simple extraction of IUD
3.9
17.0
52
142
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
3.3
16.5
65
210
K30
ICD-10 Finland
Functional dyspepsia
2.7
16.4
99
407
P76
ICPC
Depressive disorder
2.8
16.3
92
366
A02BA02
ATC
ranitidine; systemic
2.8
16.3
92
366
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.3
16.1
146
725
A02BC03
ATC
lansoprazole; oral
2.3
15.9
145
721
G01AA10
ATC
clindamycin; vaginal
2.3
15.9
149
750
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.2
15.8
65
216
N97.0
ICD-10 Finland
Female infertility associated with anovulation
163.8
15.5
16
*
LBE01
NOMESCO Finland
Laparoscopic salpingectomy
6.6
15.5
25
39
X09
ICPC
Premenstrual symptom/complaint
29.4
15.3
20
7
N03AX09
ATC
lamotrigine; oral
3.2
15.3
64
215
M79.1
ICD-10 Finland
Myalgia
2.3
15.2
142
713
N83.1
ICD-10 Finland
Corpus luteum cyst
20.6
15.2
22
11
P01AB01
ATC
metronidazole; oral, rectal
1.9
15.1
291
1908
H01CA02
ATC
nafarelin; nasal
11.2
15.1
28
26
R06AX27
ATC
desloratadine; oral
2.0
15.0
275
1772
R52.2
ICD-10 Finland
Other chronic pain
4.9
14.9
33
70
N06AX12
ATC
bupropion; oral
2.6
14.9
93
389
N81.1
ICD-10 Finland
Cystocele
18.9
14.8
22
12
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
2.0
14.7
203
1184
LEF03
NOMESCO Finland
Posterior colporrpahy with sutures for primary rectocele
+∞
14.6
14
*
TLW12
NOMESCO Finland
Insertion of frozen embryo
+∞
14.6
14
*
JAL21
NOMESCO Finland
Laparoscopic excision or destruction of lesion of peritoneum
82.0
14.6
16
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
14.6
139
702
J01AA02
ATC
doxycycline; systemic
2.1
14.5
489
3847
C07AB07
ATC
bisoprolol; oral
2.1
14.5
181
1016
H02AB06
ATC
prednisolone; systemic
1.9
14.3
293
1950
M01AE02
ATC
naproxen; oral, rectal
1.9
14.2
405
3000
LCD10
NOMESCO Finland
Vaginal hysterectomy
14.8
14.1
23
16
LCB25
NOMESCO Finland
Hysteroscopic excision of lesion
11.2
14.1
26
24
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
3.0
14.1
65
231
N05CF02
ATC
zolpidem; oral
2.3
13.8
124
610
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.5
13.8
98
435
XLA10, ,
NOMESCO Finland
4.0
13.7
39
101
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
12.4
13.7
24
20
N05BA12
ATC
alprazolam; oral
2.9
13.6
69
258
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
13.5
108
505
N06BA04
ATC
methylphenidate; oral
3.0
13.5
63
225
N03AX12
ATC
[U] gabapentin; oral
2.5
13.5
94
413
TLW10
NOMESCO Finland
Transfer of fresh embryo
142.8
13.5
14
*
R01AD58
ATC
fluticasone, combinations; nasal
1.9
13.5
244
1554
M79.6
ICD-10 Finland
Pain in limb
1.9
13.5
296
2006
G03DC02
ATC
norethisterone; oral
2.9
13.4
67
249
G03FB08
ATC
dydrogesterone and estrogen; systemic
3.8
13.4
41
112
G43.9
ICD-10 Finland
Migraine, unspecified
2.5
13.3
91
396
UJF32
NOMESCO Finland
Coloscopy
2.3
13.2
107
503
C03DA01
ATC
spironolactone; oral
3.2
13.2
55
184
J01EA01
ATC
trimethoprim; systemic
2.0
13.1
194
1152
N94.1
ICD-10 Finland
Dyspareunia
11.3
13.1
24
22
LGA21
NOMESCO Finland
Laparoscopic sterilisation by constriction of Fallopian tubes
3.3
13.0
51
164
N05CF01
ATC
zopiclone; oral
2.0
12.8
167
948
JAH01
NOMESCO Finland
Laparoscopy
4.1
12.8
35
88
J01CA08
ATC
pivmecillinam; oral
1.8
12.8
370
2715
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
3.1
12.7
54
183
F51.0
ICD-10 Finland
Nonorganic insomnia
2.0
12.7
171
982
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
12.7
147
799
P29
ICPC
Psychological sympt/compl other
2.3
12.6
101
472
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.8
12.6
66
251
N80.4
ICD-10 Finland
Endometriosis of rectovaginal septum and vagina
+∞
12.5
12
*
N95.8
ICD-10 Finland
Other specified menopausal and perimenopausal disorders
+∞
12.5
12
*
LBF01
NOMESCO Finland
Laparoscopic perfusion of Fallopian tube
132.4
12.5
13
*
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.5
12.3
30
69
N64.4
ICD-10 Finland
Mastodynia
3.2
12.3
50
165
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.9
12.1
474
3790
N76.0
ICD-10 Finland
Acute vaginitis
2.3
12.1
98
461
M01AH02
ATC
rofecoxib; oral
3.0
11.9
53
184
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.4
11.9
93
430
LCD01
NOMESCO Finland
Total laparoscopic hysterectomy
9.2
11.8
24
27
K07.60
ICD-10 Finland
Snapping jaw
2.6
11.8
70
284
R06.0
ICD-10 Finland
Dyspnoea
2.0
11.8
143
788
M25.5
ICD-10 Finland
Pain in joint
1.8
11.6
241
1587
G03GA02
ATC
human menopausal gonadotrophin; parenteral
5.2
11.5
24
48
M54.5
ICD-10 Finland
Low back pain
1.8
11.5
263
1781
N97.1
ICD-10 Finland
Female infertility of tubal origin
+∞
11.5
11
*
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
15.4
11.4
18
12
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.3
11.3
94
446
J01DA01
ATC
[U] cefalexin
1.8
11.2
406
3133
8113
FHL
Fractional scraping
20.5
11.2
16
8
LDA10
NOMESCO Finland
Curettage of cervix uteri
3.5
11.1
39
117
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
11.1
110
561
N02CC06
ATC
eletriptan; oral
3.0
11.1
49
170
F90.0
ICD-10 Finland
Disturbance of activity and attention
2.6
11.0
65
263
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
10.9
189
1173
L01
ICPC
Neck symptom/complaint
2.0
10.9
134
741
N02BE01
ATC
paracetamol; systemic, rectal
2.2
10.9
571
4933
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.0
10.8
49
172
R01AD09
ATC
mometasone; nasal
1.7
10.7
350
2607
R03AC02
ATC
salbutamol; inhalant
1.7
10.7
389
2985
N06AX22
ATC
agomelatine; oral
4.0
10.7
30
77
R51.80
ICD-10 Finland
Headache
2.0
10.7
141
799
6266A
ICD-9 Finland
Disorders of menstruation and other abnormal bleeding from female genital tract, Metrorrhagia
+∞
10.4
10
*
N03AX16
ATC
[U] pregabalin
2.1
10.4
117
625
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.4
10.4
38
117
K80
ICPC
Cardiac arrhythmia NOS
2.8
10.4
52
193
M01AH05
ATC
etoricoxib; oral
1.7
10.4
391
3020
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.9
10.3
161
963
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
3.3
10.3
40
128
N06AX03
ATC
mianserin; oral
3.9
10.3
30
79
N03AX11
ATC
topiramate; oral
3.6
10.3
34
98
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
2.0
10.3
134
755
R51.81
ICD-10 Finland
Facial pain NOS
4.2
10.2
27
66
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.1
10.2
43
145
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
4.1
10.1
28
71
Z2221
NOMESCO Finland
Medical doctor
1.8
10.0
195
1251
N05BA01
ATC
diazepam; systemic, rectal
2.4
9.9
72
322
R00.2
ICD-10 Finland
Palpitations
2.4
9.9
71
316
N97.8
ICD-10 Finland
Female infertility of other origin
26.5
9.8
13
5
1410
FHL
Laparoscopy
10.9
9.8
18
17
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
9.8
360
2743
F32
ICD-10 Finland
Depressive episode
2.5
9.8
64
272
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
3.8
9.8
30
82
J01DB01
ATC
cefalexin; oral
2.0
9.7
550
4740
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.3
9.6
81
386
D25.1
ICD-10 Finland
Intramural leiomyoma of uterus
3.1
9.6
40
134
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
9.4
150
901
G03DC03
ATC
lynestrenol; oral
4.5
9.4
23
53
ZY010
NOMESCO Finland
Hospital outpatient
2.6
9.4
56
228
SPAT1240
SPAT
Therapeutic discussion
2.0
9.3
111
604
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
4.2
9.3
25
62
G43
ICD-10 Finland
Migraine
2.2
9.3
83
405
N76.1
ICD-10 Finland
Subacute and chronic vaginitis
3.0
9.2
40
137
Z71.8
ICD-10 Finland
Other specified counselling
1.7
9.2
259
1832
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
9.2
220
1490
N04BC05
ATC
pramipexole; oral
3.3
9.2
34
106
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
9.1
268
1916
J02AC02
ATC
itraconazole; systemic
2.0
9.1
112
617
A02BC04
ATC
rabeprazole; oral
2.4
9.0
64
283
K58
ICD-10 Finland
Irritable bowel syndrome
3.5
9.0
31
92
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
3.1
8.9
37
124
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
3.4
8.9
31
93
IGY99
NOMESCO Finland
Other psychiatric treatment contact
3.4
8.9
31
93
H01CC01
ATC
ganirelix; parenteral
4.1
8.9
24
60
WYA10
NOMESCO Finland
Emergency care or similar visit
2.3
8.8
67
305
L18
ICPC
Muscle pain
3.1
8.8
36
119
R42
ICD-10 Finland
Dizziness and giddiness
1.9
8.8
120
684
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
8.8
143
863
A01
ICPC
Pain general/multiple sites
2.3
8.7
65
294
G03DB08
ATC
dienogest; oral
50.7
8.7
10
*
Z30.0
ICD-10 Finland
General counselling and advice on contraception
2.0
8.7
104
567
G01AF05
ATC
econazole; vaginal
2.3
8.6
67
308
D19
ICPC
Teeth/gum symptom/complaint
1.7
8.6
239
1678
J01FA10
ATC
azithromycin; systemic
1.7
8.6
416
3356
K03.00
ICD-10 Finland
Approximal wear
2.3
8.6
67
309
N94.8
ICD-10 Finland
Other specified conditions associated with female genital organs and menstrual cycle
16.6
8.6
13
8
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.4
8.6
58
251
F31.8
ICD-10 Finland
Other bipolar affective disorders
3.8
8.5
26
71
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
2.8
8.5
42
155
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
8.5
116
662
R01AD12
ATC
fluticasone furoate; nasal
1.6
8.5
267
1934
D01
ICPC
Abdominal pain/cramps general
2.0
8.5
101
550
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.3
8.4
65
298
UKC02
NOMESCO Finland
Cystoscopy
3.0
8.4
37
128
R52.9
ICD-10 Finland
Pain, unspecified
2.3
8.4
64
292
D06
ICPC
Abdominal pain localized other
2.2
8.4
70
332
K04
ICPC
Palpitations/awareness of heart
2.8
8.3
41
151
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.5
8.3
54
229
X02
ICPC
Menstrual pain
3.1
8.3
35
118
G43.3
ICD-10 Finland
Complicated migraine
3.5
8.3
28
82
M54.2
ICD-10 Finland
Cervicalgia
2.3
8.3
63
287
A06AC51
ATC
ispaghula, combinations; oral
3.4
8.3
29
87
D11
ICPC
Diarrhoea
1.9
8.3
111
629
F45.8
ICD-10 Finland
Other somatoform disorders
2.1
8.3
83
424
M01AG02
ATC
tolfenamic acid; oral, rectal
1.9
8.2
121
706
N30
ICD-10 Finland
Cystitis
2.1
8.2
82
418
P06
ICPC
Sleep disturbance
2.0
8.2
102
564
N02CD01
ATC
erenumab; parenteral
4.8
8.2
18
38
G03FA01
ATC
norethisterone and estrogen; systemic
2.6
8.1
49
201
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
3.7
8.1
25
69
M01AB05
ATC
diclofenac; systemic, rectal
1.6
8.1
394
3162
N80
ICD-10 Finland
Endometriosis
22.3
8.0
11
5
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
8.0
231
1630
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.9
8.0
122
720
F34.1
ICD-10 Finland
Dysthymia
3.1
8.0
33
110
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.3
8.0
59
266
N30.0
ICD-10 Finland
Acute cystitis
1.8
7.9
134
816
M54.4
ICD-10 Finland
Lumbago with sciatica
1.9
7.9
118
691
N01
ICPC
Headache
1.9
7.9
118
691
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.0
7.9
34
116
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.0
7.9
94
511
N83.0
ICD-10 Finland
Follicular cyst of ovary
8.6
7.8
16
19
A01AB09
ATC
miconazole; local oral
2.6
7.8
44
174
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
3.2
7.8
31
101
R03DC03
ATC
montelukast; oral
1.8
7.8
127
765
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
7.7
131
798
GD1AA, ,
SPAT
1.8
7.7
133
814
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.9
7.7
103
582
L03
ICPC
Low back symptom/complaint
1.7
7.7
201
1382
A06AD11
ATC
lactulose; oral
2.6
7.7
46
188
R03BA05
ATC
fluticasone; inhalant
1.8
7.7
128
777
L14
ICPC
Leg/thigh symptom/complaint
2.5
7.6
50
213
LCA10
NOMESCO Finland
Curettage of body of uterus
8.2
7.6
16
20
G54.0
ICD-10 Finland
Brachial plexus disorders
3.5
7.6
26
77
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
6.3
7.6
19
31
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.8
7.4
38
143
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
7.4
79
412
LA2HE
NOMESCO Finland
Repeated measurement of ovarian cyst
81.0
7.4
8
*
LEF00
NOMESCO Finland
Anterior colporraphy with sutures for primary cystocele
81.0
7.4
8
*
N02CC03
ATC
zolmitriptan; nasal, oral
2.3
7.4
58
268
J31.0
ICD-10 Finland
Chronic rhinitis
2.2
7.4
65
315
C07AB02
ATC
metoprolol; systemic
2.1
7.4
68
336
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
3.7
7.4
23
64
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.5
7.3
45
186
TLW14
NOMESCO Finland
ICSI
+∞
7.3
7
*
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
3.1
7.3
30
100
R30.0
ICD-10 Finland
Dysuria
2.9
7.3
34
122
N81.2
ICD-10 Finland
Incomplete uterovaginal prolapse
15.9
7.2
11
7
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.1
7.2
75
388
R02
ICPC
Shortness of breath/dyspnoea
2.1
7.2
68
339
A02BC01
ATC
omeprazole; systemic
1.7
7.2
141
895
N92
ICD-10 Finland
Excessive, frequent and irregular menstruation
3.3
7.2
26
80
C03CA01
ATC
furosemide; systemic
2.2
7.1
63
306
N02CD03
ATC
fremanezumab; systemic
4.1
7.1
19
47
X11
ICPC
Menopausal symptom/complaint
5.7
7.1
19
34
SPAT1260
SPAT
Consultation of another employee
1.9
7.1
99
567
1412
FHL
Laparoscopy and sterilization
3.7
7.1
22
61
Z2445
NOMESCO Finland
Psychologist
2.7
7.1
38
147
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
1.8
7.1
107
629
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.6
7.1
40
159
F39
ICD-10 Finland
Unspecified mood [affective] disorder
3.5
7.0
24
71
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
3.9
7.0
20
52
R01AD08
ATC
fluticasone; nasal
1.6
7.0
203
1426
G03GA06
ATC
follitropin beta; parenteral
4.4
7.0
17
39
E0000UV, ,
ATC
1.6
7.0
276
2084
N89
ICPC
Migraine
2.3
7.0
55
255
G02CB01
ATC
bromocriptine; systemic
3.8
7.0
21
57
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
3.8
7.0
21
57
F43.2
ICD-10 Finland
Adjustment disorders
3.2
6.9
27
87
J01FF01
ATC
clindamycin; systemic
1.7
6.9
151
987
N06AX05
ATC
trazodone; oral
3.5
6.9
23
67
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
3.0
6.9
29
98
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.5
6.9
44
186
R05
ICPC
Cough
1.6
6.9
174
1182
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.9
6.8
89
499
LBE20
NOMESCO Finland
Laparoscopic bilateral salpingectomy
6.2
6.8
17
28
G04BD12
ATC
mirabegron; oral
2.8
6.8
33
121
A03FA01
ATC
metoclopramide; systemic, rectal
1.7
6.8
136
868
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
6.7
108
646
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
6.7
115
701
G03FB05
ATC
norethisterone and estrogen; systemic
2.5
6.7
40
163
R03AC13
ATC
formoterol; inhalant
3.1
6.7
28
94
M01AH01
ATC
celecoxib; oral
2.0
6.7
72
377
L17
ICPC
Foot/toe symptom/complaint
1.6
6.7
173
1180
LAF01
NOMESCO Finland
Laparoscopic unilateral salpingo-oophorectomy
7.9
6.6
14
18
M03BC51
ATC
orphenadrine, combinations; systemic
1.6
6.6
171
1165
N03AG01
ATC
valproic acid; systemic, rectal
2.4
6.6
44
189
SPAT1104
SPAT
Monitoring of emergency patient
2.8
6.6
32
117
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.4
6.6
43
183
3007
Kela drug reimbursment
Erenumab and fremanezumab
3.4
6.6
23
69
A27
ICPC
Fear of other disease NOS
2.8
6.6
33
123
D93
ICPC
Irritable bowel syndrome
4.2
6.6
17
41
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.1
6.6
65
330
K07.69
ICD-10 Finland
Dislocation of the jaw joint UNS
3.9
6.6
19
50
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.7
6.6
35
135
H53.1
ICD-10 Finland
Subjective visual disturbances
2.3
6.5
48
216
Z01.2
ICD-10 Finland
Dental examination
1.5
6.5
341
2725
R06AX22
ATC
ebastine; oral
1.7
6.5
134
862
M01AX17
ATC
nimesulide; oral
1.9
6.5
79
433
N85.0
ICD-10 Finland
Endometrial glandular hyperplasia
70.5
6.4
7
*
H03AA01
ATC
levothyroxine sodium; systemic
1.7
6.4
150
996
ZYC01
NOMESCO Finland
Remote contact by phone
2.3
6.4
47
212
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
6.3
247
1850
R04
ICPC
Breathing problem other
3.3
6.3
23
71
N02CC05
ATC
almotriptan; oral
2.3
6.3
46
206
LAC01
NOMESCO Finland
Laparoscopic excision of ovarian cyst
11.2
6.3
11
10
LEB00
NOMESCO Finland
Biopsy of vagina
9.4
6.3
12
13
R07.0
ICD-10 Finland
Pain in throat
2.0
6.3
70
371
M54.1
ICD-10 Finland
Radiculopathy
3.1
6.3
26
87
P74
ICPC
Anxiety disorder/anxiety state
2.1
6.3
58
287
R2110
NOMESCO Finland
Giving the first information
2.2
6.3
50
233
R06AX26
ATC
fexofenadine; oral
2.1
6.3
61
308
N94.2
ICD-10 Finland
Vaginismus
+∞
6.3
6
*
6262A
ICD-9 Finland
Disorders of menstruation and other abnormal bleeding from female genital tract, Excessive or frequent menstruation[HYPERMENORRHOEA]
+∞
6.3
6
*
N95.9
ICD-10 Finland
Menopausal and perimenopausal disorder, unspecified
+∞
6.3
6
*
N80.8
ICD-10 Finland
Other endometriosis
+∞
6.3
6
*
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
3.1
6.3
25
82
UJF30
NOMESCO Finland
Ileoscopy through colon
2.2
6.2
55
267
LCB98
NOMESCO Finland
Other transluminal endoscopic excision of lesion of uterus
26.9
6.2
8
*
JHB00
NOMESCO Finland
Hemorrhoidectomy
3.7
6.2
19
52
XKD00
NOMESCO Finland
Uroflowmetry
3.7
6.2
19
52
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
2.6
6.2
35
139
IDY03
NOMESCO Finland
Systematic individual therapy, cognitive-behavioural
2.2
6.2
54
261
K03.80
ICD-10 Finland
Irradiated enamel
2.1
6.2
55
268
N73.9
ICD-10 Finland
Female pelvic inflammatory disease, unspecified
3.4
6.2
22
67
R60.9
ICD-10 Finland
Oedema, unspecified
2.8
6.2
31
116
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
2.8
6.1
29
105
D06BB10
ATC
imiquimod; topical
2.6
6.1
34
134
O99.80
ICD-10 Finland
The fear of childbirth
1.9
6.1
82
464
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
3.7
6.1
19
53
N84.1
ICD-10 Finland
Polyp of cervix uteri
8.7
6.1
12
14
R03BA08
ATC
ciclesonide; inhalant
2.1
6.1
60
305
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.5
6.1
37
153
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.3
6.0
22
68
J01MA02
ATC
ciprofloxacin; systemic
1.6
6.0
171
1189
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
2.3
6.0
45
204
A13
ICPC
Concern/fear medical treatment
6.1
6.0
15
25
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
3.9
6.0
17
44
K59.09
ICD-10 Finland
Constipation, unspecified
2.9
6.0
27
95

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
178
489
4.63
60.61
1.6
1.3
12.97
19.07
iu/l
2.75
159
419
67
124
5.90
35.32
1.3
1.2
8.36
11.12
u/l
0.83
52
95
55
103
5.74
28.54
1.4
1.4
0.46
0.41
nmol/l
0.20
45
81
599
4683
4.26
27.23
6.5
4.5
14.15
14.26
pmol/l
0.63
583
4423
40
70
6.02
22.21
1.3
1.4
1.16
2.28
nmol/l
1.62
34
61
475
3426
2.41
22.20
4.2
3.1
54.60
61.00
ug/l
1.74
463
3282
407
2775
2.23
21.41
5.3
6.4
1.97
2.00
e9/l
0.30
365
2517
397
2692
2.21
21.01
5.3
6.4
0.04
0.04
e9/l
0.00
348
2390
289
1732
2.20
20.92
2.1
1.8
100.42
97.92
pmol/l
0.40
174
982
364
2398
2.17
20.57
2.9
2.3
76.61
71.58
nmol/l
3.29
343
2286
395
2690
2.18
20.45
5.3
6.4
0.50
0.52
e9/l
0.72
346
2393
629
5347
5.44
19.79
7.8
5.1
1.59
1.74
mu/l
4.12
617
5131
405
2816
2.15
19.47
5.4
6.7
0.17
0.18
e9/l
0.01
363
2532
269
1615
2.13
18.91
1.4
1.3
1.26
2.04
u/ml
0.72
73
468
421
2993
2.14
18.80
7.1
9.5
3.82
4.04
e9/l
1.61
377
2650
480
3624
2.21
17.89
6.5
6.9
67.88
72.70
u/l
2.50
461
3463
472
3545
2.19
17.76
5.0
3.5
1405.83
2635.45
e6/l
—
6
33
168
859
2.29
17.44
2.5
2.6
128.63
89.33
ug/g
0.58
133
674
369
2555
2.02
16.98
5.0
6.1
56.87
56.86
%
0.01
360
2459
373
2596
2.01
16.88
5.1
6.2
29.80
29.74
%
0.04
358
2491
358
2473
1.99
16.36
5.2
6.3
0.69
0.67
%
0.25
343
2341
356
2478
1.96
15.66
5.2
6.3
2.59
2.64
%
0.19
342
2353
357
2490
1.95
15.58
5.2
6.3
7.79
8.08
%
1.59
343
2368
296
1944
1.95
15.38
2.0
1.7
—
—
—
0
0
564
4692
2.45
14.57
4.8
4.1
35.63
36.86
mmol/mol
4.11
540
4492
239
1485
1.96
14.40
2.6
3.3
2.35
2.34
mmol/l
0.32
226
1398
116
546
2.37
14.37
1.2
1.2
—
—
—
0
0
114
536
2.36
14.15
1.9
2.3
348.65
379.61
nmol/l
1.28
106
506
323
2226
1.89
14.14
3.4
2.8
6.35
6.26
ph
0.79
198
1265
222
1367
1.94
13.58
2.1
2.4
54.89
59.06
u/l
0.60
209
1286
88
375
2.56
13.49
1.3
1.2
—
—
—
0
0
221
1368
1.93
13.25
1.5
1.4
1.92
2.11
g/l
2.04
139
923
162
900
2.06
13.22
1.5
1.4
375.48
682.54
titre
1.80
31
189
383
2829
1.85
13.07
3.8
3.1
32.51
0.01
estimate
0.79
76
610
98
448
2.40
12.90
1.4
1.4
—
—
—
0
0
188
1110
1.97
12.90
2.0
2.0
262.12
140.53
u/l
0.34
182
1065
321
2265
1.82
12.53
3.9
5.6
9.47
9.83
umol/l
0.37
305
2140
268
1793
1.84
12.43
3.8
4.6
37.38
37.13
g/l
0.34
258
1702
153
851
2.04
12.37
1.7
1.5
—
—
—
0
0
104
500
2.28
12.17
1.9
1.6
1178.87
1158.02
nmol/l
0.09
93
384
375
2800
1.79
11.86
3.7
3.1
0.00
0.00
estimate
0.50
75
599
377
2833
1.78
11.54
3.9
3.1
0.03
0.01
estimate
0.37
73
596
179
1076
1.91
11.47
1.6
1.3
8.22
9.31
u/ml
0.08
65
464
259
1752
1.79
11.33
3.4
3.2
93.38
87.49
e6/l
0.05
173
1072
41
127
3.38
11.13
1.4
1.2
6.59
24.29
u/l
7.65
28
106
598
5257
2.58
11.13
11.6
9.4
139.33
139.48
mmol/l
0.99
592
5129
282
1969
1.76
10.97
5.8
5.9
1.22
1.21
mmol/l
1.85
255
1703
30
76
4.09
10.86
1.7
1.6
357.43
392.54
mu/l
0.25
21
54
193
1212
1.84
10.68
1.6
1.3
20.38
24.25
iu/ml
0.22
52
330
203
1299
1.82
10.54
2.4
2.4
11.85
23.96
ng/l
2.02
66
543
597
5271
2.50
10.52
11.6
9.4
3.89
3.88
mmol/l
0.45
589
5126
621
5595
3.12
10.38
12.4
9.9
15.97
18.73
mg/l
1.78
509
4367
44
151
3.05
10.12
1.1
1.1
—
—
—
0
0
198
1273
1.80
10.05
2.5
2.0
2.49
2.45
mg/l
0.07
174
1127
298
2156
1.70
9.91
3.5
2.9
0.02
0.02
estimate
0.01
62
506
99
510
2.11
9.68
1.5
1.4
—
—
—
0
0
169
1046
1.83
9.68
1.5
1.5
20.57
19.95
nmol/l
0.29
148
945
638
5872
4.33
9.64
10.8
8.8
22.46
23.09
u/l
0.69
630
5744
112
610
2.01
9.41
1.4
1.3
85.25
152.33
u/ml
1.20
42
248
189
1224
1.76
9.24
3.9
3.0
1.02
1.02
kg/l
0.19
121
782
180
1169
1.74
8.63
1.7
1.6
0.57
0.81
mg/l
2.31
127
849
348
2684
1.63
8.61
3.7
4.1
6.01
6.26
mmol/l
1.47
314
2381
246
1740
1.66
8.59
5.1
5.1
1.23
1.22
mmol/l
1.40
235
1638
40
144
2.89
8.48
1.1
1.1
—
—
—
0
0
40
144
2.89
8.48
1.1
1.1
—
—
—
0
0
126
740
1.87
8.42
2.4
2.3
2.41
2.40
mmol/l
0.23
110
669
492
4166
1.73
8.26
3.4
2.7
29.53
31.35
u/l
0.29
478
4027
633
5860
3.39
8.18
13.5
11.0
65.78
65.15
umol/l
0.41
627
5793
565
4992
1.96
8.15
4.5
3.4
5.43
5.57
mmol/l
3.08
548
4716
206
1424
1.65
7.70
4.1
4.2
—
—
—
0
0
231
1650
1.62
7.55
2.9
2.4
0.00
0.02
estimate
1.74
65
494
299
2271
1.58
7.54
2.3
2.1
—
—
—
0
0
217
1532
1.62
7.41
6.1
6.1
1.07
1.06
inr
0.26
181
1271
316
2438
1.57
7.40
8.5
8.9
0.00
0.00
e9/l
0.18
260
2011
177
1189
1.67
7.35
3.1
3.5
7.39
7.39
ph
0.06
125
835
80
422
2.02
7.30
2.6
2.3
33.78
19.49
au/ml
0.57
15
52
47
199
2.47
7.29
1.7
2.6
—
—
—
0
0
196
1359
1.63
7.16
2.9
2.7
45.79
115.64
e6/l
0.72
149
983
131
817
1.75
7.11
2.0
1.6
430.98
40668948.88
pmol/l
1.34
121
718
640
6011
3.83
7.09
12.0
8.9
—
—
—
0
0
327
2571
1.54
6.86
2.5
2.5
—
—
estimate
—
0
0
90
507
1.90
6.79
1.3
1.3
84.59
259.67
u/ml
2.57
80
468
137
891
1.68
6.34
2.5
2.3
5.95
9.63
e6/l
3.29
121
781
103
620
1.78
6.28
2.9
3.3
0.83
0.83
mmol/l
0.02
97
595
91
529
1.84
6.22
1.2
1.2
—
—
—
0
0
255
1933
1.52
6.14
1.8
1.7
—
—
—
0
0
28
100
2.88
6.07
1.2
1.3
347.07
337.83
ug/g
0.07
14
50
222
1640
1.53
5.99
1.9
1.8
—
—
—
0
0
90
529
1.81
5.93
1.3
1.1
—
—
—
0
0
70
380
1.94
5.89
3.8
5.0
0.20
0.05
%
—
10
82
71
393
1.90
5.64
3.8
5.4
0.00
0.93
%
0.50
11
86
168
1181
1.57
5.61
2.7
2.6
0.13
0.32
e6/l
2.39
121
817
51
252
2.11
5.56
1.6
1.7
15.40
9.68
u/ml
—
8
75
100
618
1.73
5.55
2.5
2.3
2.47
2.50
g/l
0.22
93
570
240
1834
1.49
5.40
3.1
3.1
24.69
27.39
u/l
1.39
228
1747
147
1010
1.59
5.40
2.0
2.0
281.44
294.44
umol/l
1.07
133
924
71
400
1.87
5.35
3.8
4.9
0.82
0.65
%
0.17
11
103
591
5452
1.86
5.34
4.6
3.8
2.89
2.87
mmol/l
0.22
577
5236
29
114
2.62
5.28
2.1
1.4
—
—
—
0
0
205
1523
1.50
5.27
5.0
5.9
—
—
—
0
0
68
380
1.88
5.26
3.5
4.7
0.23
0.51
%
1.00
13
93
121
798
1.63
5.25
2.5
2.4
471.27
522.06
mosm/kgh2o
1.54
105
692
77
453
1.79
5.06
2.0
1.9
—
—
—
0
0
551
5007
1.63
4.99
3.7
3.1
1.12
1.13
mmol/l
0.32
533
4796
586
5419
1.77
4.88
4.3
3.6
4.80
4.80
mmol/l
0.02
573
5221
75
443
1.78
4.86
2.0
2.2
42.76
40.19
u/l
0.10
63
367
193
1437
1.49
4.85
2.3
2.2
—
—
—
0
0
7
5
14.13
4.58
1.0
1.0
0.02
0.01
u/ml
—
7
5
18
59
3.11
4.54
1.3
1.2
—
—
—
0
0
80
493
1.71
4.48
2.0
1.9
—
—
—
0
0
80
496
1.70
4.38
1.9
1.9
—
—
—
0
0
82
512
1.69
4.38
2.0
1.8
—
—
—
0
0
57
320
1.86
4.37
1.2
1.2
—
—
—
0
0
80
499
1.69
4.29
1.9
1.9
—
—
—
0
0
79
492
1.69
4.26
2.0
1.9
—
—
—
0
0
14
41
3.47
4.20
1.1
1.1
—
—
—
0
0
62
364
1.78
4.12
2.3
2.6
—
—
—
0
0
29
130
2.29
4.05
1.3
1.4
—
—
—
0
0
7
7
10.09
4.02
1.1
1.1
—
—
u/ml
—
0
0
81
518
1.64
3.96
1.7
1.7
—
—
—
0
0
97
649
1.58
3.94
3.0
2.8
1377.67
391.62
ng/l
0.37
48
287
166
1244
1.45
3.94
3.8
3.1
—
0.00
—
0
11
69
424
1.70
3.92
4.7
5.9
1.03
1.04
mmol/l
0.18
59
396
44
236
1.93
3.89
2.6
2.3
4.85
4.68
umol/l
0.07
28
179
52
296
1.82
3.83
1.2
1.1
—
—
—
0
0
12
28
4.35
3.83
1.0
1.4
1005.67
749.21
mu/l
0.12
12
28
160
1197
1.45
3.82
1.8
1.8
—
—
—
0
0
64
388
1.72
3.82
1.6
1.9
—
—
—
0
0
191
1480
1.41
3.75
4.1
3.2
0.00
0.00
estimate
0.50
68
576
36
184
2.01
3.65
1.1
1.1
5.25
6.70
u/ml
0.25
18
105
578
5403
1.59
3.64
4.2
3.5
1.54
1.54
mmol/l
0.04
563
5193
27
124
2.23
3.59
1.2
1.4
153.44
153.12
au/ml
—
9
43
93
635
1.54
3.46
2.3
2.5
2.75
5.11
e6/l
2.08
44
287
18
70
2.62
3.41
1.2
1.2
—
—
—
0
0
11
28
3.98
3.30
1.0
1.4
72.00
70.93
%
0.10
11
28
48
282
1.76
3.22
1.6
2.3
6.17
8.43
iu/ml
0.33
12
63
46
272
1.74
3.03
1.1
1.1
—
—
—
0
0
33
177
1.91
2.96
1.1
1.1
0.86
0.84
u/ml
0.02
17
80
57
360
1.64
2.96
1.6
1.3
—
—
—
0
0
300
2566
1.31
2.96
2.3
2.3
—
—
—
0
0
92
649
1.49
2.95
2.6
2.0
4237.61
6131.95
u/l
0.30
35
246
68
449
1.57
2.95
2.4
1.9
6.50
6.24
ph
1.18
40
291
79
543
1.52
2.87
1.3
1.5
—
—
—
0
0
84
586
1.50
2.84
1.7
1.7
—
—
—
0
0
37
213
1.78
2.69
1.2
1.1
3.38
7.43
eliau/ml
—
5
43
160
1265
1.35
2.69
1.8
1.6
—
—
—
0
0
31
169
1.88
2.67
1.3
1.2
—
—
—
0
0
65
435
1.55
2.67
1.8
1.9
0.00
0.00
estimate
-0.00
13
103
29
155
1.91
2.65
2.4
2.0
—
—
—
0
0
33
185
1.83
2.62
1.1
1.2
—
—
—
0
0
37
215
1.76
2.61
1.1
1.1
3.93
2.77
u/ml
0.18
18
110
43
261
1.69
2.61
4.5
3.3
—
—
—
0
0
39
231
1.73
2.58
2.1
2.2
3.01
3.67
iu/l
0.45
16
113
50
317
1.62
2.58
4.3
3.1
7.36
7.34
ph
0.25
36
237
27
144
1.91
2.50
1.1
1.2
—
—
—
0
0
46
289
1.64
2.47
3.1
3.7
7.38
7.38
ph
0.25
25
162
30
170
1.80
2.32
2.4
3.2
101.63
84.96
ng/l
0.29
24
146
88
648
1.41
2.27
2.4
2.9
3.98
4.77
e9/l
0.87
77
595
7
19
3.71
2.15
3.0
2.8
8.96
16.77
umol/l
—
7
19
41
261
1.61
2.12
1.3
1.6
0.23
0.27
mg/l
0.18
15
98
26
146
1.81
2.09
6.3
6.2
—
—
—
0
0
10
37
2.73
2.07
2.0
1.9
10.60
14.24
%
—
10
37
12
50
2.43
2.03
1.5
1.9
—
—
—
0
0
82
609
1.40
2.03
1.6
1.3
—
—
—
0
0
31
186
1.70
2.01
1.1
1.1
1.02
1.50
u/ml
0.30
17
86
10
38
2.66
2.01
1.8
2.3
48.36
44.21
%
—
10
38
11
45
2.47
1.94
1.2
1.2
—
—
nmol/l
—
0
0
124
991
1.31
1.92
2.3
2.1
—
—
—
0
0
26
151
1.75
1.89
1.2
1.2
—
—
—
0
0
24
137
1.78
1.85
5.3
3.2
392.80
385.71
mg/l
—
10
56
244
2125
1.24
1.85
1.8
1.8
—
—
—
0
0
95
735
1.34
1.84
1.6
1.5
3.52
3.31
mmol/l
1.16
62
479
7
23
3.07
1.80
1.0
1.1
—
7.89
—
0
9
37
240
1.57
1.80
7.6
7.9
—
—
—
0
0
30
186
1.64
1.75
1.5
1.3
46.40
14.45
u/ml
—
5
28
12
54
2.25
1.74
1.3
1.2
0.46
0.51
nmol/l
0.38
12
54
7
24
2.94
1.72
2.7
1.4
95.57
76.05
nmol/24h
—
7
24
159
1331
1.26
1.71
3.2
3.4
7.36
7.86
mmol/l
0.61
129
1175
203
1747
1.23
1.70
1.8
1.8
—
—
—
0
0
26
157
1.68
1.68
1.0
1.1
0.94
5.68
u/ml
2.46
12
64
28
173
1.65
1.66
1.2
1.6
—
11.95
—
0
6
14
69
2.05
1.65
1.1
1.0
4.90
8.29
iu/ml
—
6
18
10
41
2.46
1.65
2.0
1.9
79.40
73.39
%
—
10
41
10
42
2.40
1.62
1.4
1.0
6.80
7.33
mm/h
—
10
42
8
32
2.52
1.60
1.9
2.1
99.63
218.31
e6/l
—
8
32
8
32
2.52
1.60
1.0
1.1
—
—
—
0
0
6
20
3.02
1.58
4.8
2.1
1.10
1.36
ug/l
—
6
20
117
953
1.28
1.57
1.7
1.6
3.27
3.22
ratio
0.17
84
682
21
122
1.75
1.56
1.1
1.1
1.50
4.70
eliau/ml
—
10
63
63
470
1.38
1.55
3.2
2.9
—
—
—
0
0
5
15
3.35
1.52
1.0
2.4
67.60
114.53
ng/l
—
5
15
25
154
1.65
1.52
1.2
1.3
—
—
—
0
0
13
65
2.02
1.49
1.4
1.2
—
—
—
0
0
43
304
1.44
1.44
1.3
1.2
—
—
—
0
0
5
16
3.14
1.44
1.2
1.0
—
—
—
0
0
11
53
2.09
1.39
11.1
14.4
0.79
0.64
mmol/l
0.30
11
48
40
283
1.44
1.35
3.2
3.7
5.84
5.71
kpa
0.35
40
273
0
39
0.00
1.34
0.0
1.4
—
—
—
0
0
11
54
2.05
1.33
1.5
1.6
0.45
0.49
e9/l
0.22
11
54
8
34
2.37
1.29
1.8
2.3
0.87
0.82
e9/l
—
8
34
5
18
2.79
1.28
1.0
2.7
0.00
0.00
estimate
—
5
18
5
18
2.79
1.28
2.2
1.9
6.00
10.89
%
—
5
18
11
55
2.02
1.28
1.1
1.2
—
—
—
0
0
22
138
1.61
1.27
1.0
1.1
0.06
0.10
u/ml
—
8
36
31
213
1.48
1.23
1.7
2.1
0.00
0.03
estimate
0.80
11
77
11
56
1.98
1.22
1.1
1.5
—
—
—
0
0
18
109
1.67
1.20
1.4
1.3
—
—
—
0
0
71
564
1.29
1.19
1.6
2.1
5.18
6.11
umol/l
0.31
63
471
8
38
2.12
1.18
1.3
1.4
2500.00
1932.95
ml
—
8
38
11
57
1.95
1.17
1.9
1.6
68.18
26.53
ng/l
0.41
11
57
15
87
1.74
1.16
2.5
2.3
—
—
—
0
0
8
39
2.06
1.15
1.0
1.1
—
—
—
0
0
5
20
2.51
1.15
2.2
2.0
23.60
26.15
%
—
5
20
5
20
2.51
1.15
1.0
2.9
17.98
369.68
ug/l
—
5
20
10
51
1.98
1.11
2.2
1.6
—
—
—
0
0
19
120
1.60
1.09
1.8
2.2
14.80
3.33
index
—
10
49
233
2105
1.17
1.09
1.9
1.7
1.27
1.28
mmol/l
0.10
208
1885
5
21
2.39
1.09
1.0
1.0
—
—
—
0
0
5
21
2.39
1.09
3.4
3.0
—
—
—
0
0
11
59
1.88
1.08
1.0
1.1
—
—
—
0
0
23
153
1.52
1.07
1.2
1.2
230.23
227.22
u/ml
0.02
16
104
9
46
1.97
1.04
2.1
1.7
59.11
76.22
mmol/l
—
9
36
5
22
2.28
1.03
2.2
2.0
8.60
8.05
%
—
5
22
5
22
2.28
1.03
2.2
1.9
32.40
25.41
%
—
5
22
19
122
1.57
1.03
1.9
3.7
58.64
56.75
%
0.38
19
122
27
188
1.45
1.03
2.7
2.7
7.41
7.41
ph
0.19
21
155
12
68
1.78
1.01
1.0
1.1
—
—
—
0
0
32
232
1.40
0.99
3.2
2.8
5.50
4.89
kpa
0.51
32
222
24
167
1.45
0.93
1.0
1.1
1.76
4.42
u/ml
1.02
13
77
20
134
1.51
0.92
2.6
2.6
0.66
0.62
%
0.21
20
134
57
457
1.27
0.92
1.5
1.3
341.43
221.29
miu/ml
1.19
28
252
40
306
1.33
0.91
1.5
2.4
1.75
1.71
%
0.08
35
273
13
79
1.66
0.88
1.2
2.0
—
—
—
0
0
6
31
1.94
0.84
1.8
1.8
—
2445.71
—
0
7
12
73
1.66
0.82
1.0
1.0
—
—
—
0
0
6
32
1.88
0.82
2.0
2.3
—
—
—
0
0
0
26
0.00
0.78
0.0
2.5
—
615.06
—
0
18
13
82
1.60
0.78
2.2
2.1
—
—
—
0
0
0
27
0.00
0.77
0.0
1.9
—
1.34
—
0
21
22
157
1.42
0.77
1.1
1.1
5.51
9.70
au/ml
—
7
49
30
227
1.34
0.76
1.2
2.7
67.83
68.39
g/l
0.16
30
213
5
25
2.01
0.73
1.0
1.2
70.80
67.52
umol/l
—
5
25
26
195
1.35
0.70
1.4
2.6
79.14
72.22
e9/l
0.46
20
130
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
5
28
1.79
0.66
1.0
1.1
26.40
27.21
s
—
5
28
0
21
0.00
0.60
0.0
2.5
—
487.44
—
0
16
11
72
1.54
0.59
1.0
1.4
—
—
—
0
0
25
194
1.30
0.56
1.6
1.6
—
—
—
0
0
16
116
1.39
0.55
3.8
2.9
—
—
—
0
0
128
1170
1.12
0.51
1.5
1.6
1015.11
1033.65
mu/l
0.08
101
954
10
67
1.50
0.50
1.4
1.4
—
—
—
0
0
61
533
1.16
0.48
1.5
1.5
1.34
1.27
mm
0.25
40
374
62
543
1.16
0.47
1.5
1.5
—
—
—
0
0
63
553
1.15
0.47
1.6
1.5
—
—
—
0
0
16
120
1.34
0.46
1.5
1.3
12.86
5.43
u/ml
—
7
51
7
49
1.43
0.46
1.1
1.1
—
65.00
—
0
5
111
1014
1.11
0.45
4.0
4.4
12.95
12.10
mg/mmol
0.05
59
633
17
130
1.32
0.44
1.2
1.1
—
—
—
0
0
13
95
1.38
0.44
1.1
1.0
—
—
—
0
0
5
33
1.52
0.41
1.6
3.0
250.00
680.55
u/ml
—
5
33
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
19
150
1.27
0.40
1.8
1.8
4.13
5.68
ug/l
0.28
14
132
5
34
1.47
0.40
1.2
1.1
—
10.80
—
0
7
38
325
1.18
0.40
7.5
8.5
0.95
0.71
mmol/l
0.17
29
256
8
61
1.32
0.39
1.5
2.5
75.00
62.85
%
—
8
61
10
71
1.41
0.39
1.4
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
35
299
1.18
0.38
2.1
2.7
1.25
1.23
mmol/l
0.98
30
258
9
68
1.33
0.37
1.2
1.3
—
—
—
0
0
20
161
1.25
0.37
11.8
11.7
15.81
15.84
%
0.01
20
156
15
116
1.30
0.37
1.2
1.1
—
—
—
0
0
38
328
1.17
0.37
8.3
8.6
7.40
7.42
ph
0.98
16
186
17
135
1.27
0.35
1.9
1.9
11.19
10.94
mg/l
0.04
17
130
109
1011
1.09
0.35
3.6
3.7
68.31
66.05
mg/l
0.03
62
641
11
82
1.35
0.34
2.7
2.5
6.75
6.20
pmol/l
0.14
11
82
7
54
1.30
0.30
1.0
1.1
1549.00
1521.06
miu/ml
—
7
54
15
120
1.26
0.30
6.9
9.5
0.99
0.92
%
0.31
15
114
13
102
1.28
0.30
1.1
1.1
—
—
—
0
0
8
64
1.25
0.27
2.5
2.3
—
—
—
0
0
73
674
1.09
0.27
1.5
1.5
67.91
59.11
ug/l
0.76
56
557
31
352
0.87
0.26
1.1
1.1
0.86
0.86
g/l
0.03
31
352
13
104
1.26
0.26
1.1
1.2
—
—
—
0
0
15
123
1.22
0.25
7.0
9.3
1.61
1.62
%
0.03
15
118
20
170
1.18
0.24
1.2
2.5
—
—
—
0
0
9
76
1.19
0.24
1.3
1.4
—
—
—
0
0
31
349
0.88
0.24
1.1
1.1
1.60
1.59
g/l
0.11
31
349
5
39
1.28
0.23
1.0
1.0
98.20
119.69
pmol/l
—
5
39
7
93
0.75
0.22
1.6
1.3
—
61.59
—
0
7
5
41
1.22
0.22
1.0
1.2
—
—
—
0
0
5
41
1.22
0.22
1.0
1.8
92.78
91.85
%
—
5
41
0
11
0.00
0.21
0.0
2.7
—
—
—
0
0
12
98
1.23
0.21
2.4
4.2
3.64
3.89
e9/l
0.32
12
98
0
12
0.00
0.21
0.0
2.5
—
0.18
—
0
12
0
12
0.00
0.21
0.0
3.1
—
—
—
0
0
7
60
1.17
0.18
1.0
1.2
—
—
—
0
0
7
62
1.13
0.17
1.1
1.4
—
—
—
0
0
7
62
1.13
0.17
1.1
1.4
—
—
—
0
0
7
62
1.13
0.17
1.1
1.4
—
—
—
0
0
7
62
1.13
0.17
1.1
1.4
—
—
—
0
0
94
900
1.05
0.15
3.6
3.6
—
—
—
0
0
22
199
1.11
0.13
1.1
1.3
—
—
—
0
0
5
44
1.14
0.10
1.0
1.9
1.58
2.08
mmol/l
—
5
44
6
55
1.09
0.09
4.5
2.2
6.90
7.87
mmol/l
—
6
55
6
57
1.05
0.08
1.5
1.1
1.08
1.04
ratio
—
6
45
6
73
0.82
0.07
1.3
1.1
202.17
204.74
mg/l
—
6
65
6
74
0.81
0.07
1.5
1.2
30.03
36.00
mg/l
—
6
62
36
346
1.04
0.05
1.2
1.3
—
—
—
0
0
18
169
1.07
0.05
7.3
10.1
24.14
24.12
mmol/l
0.01
18
163
89
878
1.02
0.03
1.3
1.3
—
—
—
0
0
14
134
1.05
0.00
1.2
1.4
—
—
—
0
0
14
145
0.96
0.00
4.8
9.1
—
—
—
0
0
15
145
1.04
0.00
1.3
1.4
1.43
21.85
e6/l
—
7
112
15
147
1.02
0.00
1.3
1.4
0.44
460.72
e6/l
—
9
117
5
57
0.88
0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.2
—
—
—
0
0
7
69
1.01
-0.00
1.4
2.0
26.57
30.13
umol/l
—
7
62
0
6
0.00
-0.00
0.0
7.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
1.21
—
0
9
0
5
0.00
-0.00
0.0
2.6
—
2.33
—
0
5
5
51
0.98
-0.00
5.2
3.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
244.20
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
0.13
—
0
6
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
2.75
—
0
8
0
6
0.00
-0.00
0.0
2.5
—
6.37
—
0
6
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
70.80
—
0
5
0
7
0.00
-0.00
0.0
3.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
63.71
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint N14_PREMENSTSYNDROM and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_PREMENSTSYNDROM.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: N14_PREMENSTSYNDROM – Premenstrual syndrome

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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