Herpesviral keratitis and keratoconjunctivitis

H7_HERPESKERATITIS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

1928

4. Check minimum number of events

None

1928

5. Include endpoints

None

1928

6. Filter based on genotype QC (FinnGen only)

1718

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12217 6572 5592
Only index persons 11504 6258 5246
Unadjusted period prevalence (%)
Whole population 0.17 0.19 0.16
Only index persons 0.22 0.23 0.20
Median age at first event (years)
Whole population 53.84 55.22 52.20
Only index persons 53.05 54.42 51.40

-FinnGen-

Key figures

All Female Male
Number of individuals 1718 972 746
Unadjusted period prevalence (%) 0.34 0.35 0.34
Median age at first event (years) 56.78 54.50 59.75

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1777
Matched controls
17770
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J05AB11
ATC
valaciclovir; oral
6.7
315.9
690
1544
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
4503599627370496.0
307.7
1506
*
H19.1
ICD-10 Finland
Herpesviral keratitis and keratoconjunctivitis
6280.6
307.7
478
*
H16.0
ICD-10 Finland
Corneal ulcer
41.4
307.7
398
123
S01AD03
ATC
aciclovir; ophthalmic
272.8
307.7
1316
184
H16.9
ICD-10 Finland
Keratitis, unspecified
427.6
307.7
320
9
J05AB01
ATC
aciclovir; systemic
10.3
307.7
1112
2478
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.1
234.3
1228
5418
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
379.0
232.0
229
7
B00.5
ICD-10 Finland
Herpesviral ocular disease
247.3
195.8
198
9
H04.10
ICD-10 Finland
Dry eye syndrome
4.9
163.7
438
1111
H03.1*B00.5
ICD-10 Finland
Herpesviral dermatitis of eyelid
56.4
160.8
91
17
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.3
130.0
864
3988
B00.10
ICD-10 Finland
Herpes simplex facialis
21.5
122.1
92
45
H19.2*B02.3
ICD-10 Finland
Keratitis and keratoconjunctivitis (interstitial) in zoster
185.0
85.0
88
5
H57.1
ICD-10 Finland
Ocular pain
6.2
82.2
148
258
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.3
80.8
230
595
B02.3
ICD-10 Finland
Zoster ocular disease
40.2
77.0
47
12
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.5
76.7
301
972
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.8
74.1
462
1952
H16.2
ICD-10 Finland
Keratoconjunctivitis
113.4
70.4
76
7
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
70.3
67
*
S01ED01
ATC
timolol; ophthalmic
6.1
69.6
125
217
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
16.0
68.5
59
38
H15.1
ICD-10 Finland
Episcleritis
19.2
68.5
54
29
CG2T4
NOMESCO Finland
Topography assessment of cornea
26.8
68.2
47
18
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
9.8
68.2
80
85
F01
ICPC
Eye pain
6.3
67.5
117
196
S01BA01
ATC
dexamethasone; ophthalmic
6.1
66.4
119
206
S01FA04
ATC
cyclopentolate; ophthalmic
16.7
65.2
55
34
D11AX14
ATC
[U] tacrolimus
23.1
61.7
45
20
S01ED51
ATC
timolol, combinations; ophthalmic
3.6
61.2
220
667
S01EC01
ATC
acetazolamide; systemic
7.7
60.1
86
117
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.8
59.8
351
1421
H18.8
ICD-10 Finland
Other specified disorders of cornea
210.4
59.4
61
*
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
76.3
58.5
66
9
S01EA05
ATC
brimonidine; ophthalmic
6.7
58.3
95
149
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.6
55.8
199
599
D11AH01
ATC
tacrolimus; topical
12.6
54.9
54
44
H22.0*B00.5
ICD-10 Finland
Herpesviral iridocyclitis
+∞
53.4
51
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
522.7
51.7
51
*
S01AX11
ATC
[U] ofloxacin
4.9
49.8
113
242
Z94.7
ICD-10 Finland
Corneal transplant status
459.1
45.5
45
*
H16.1
ICD-10 Finland
Other superficial keratitis without conjunctivitis
85.8
45.1
50
6
S01BA04
ATC
prednisolone; ophthalmic
7.1
44.7
68
99
H13.1*B00.5
ICD-10 Finland
Herpesviral conjunctivitis
98.7
44.0
48
5
S01AA01
ATC
chloramphenicol; ophthalmic
3.8
42.1
136
381
S01EA03
ATC
apraclonidine; ophthalmic
10.2
41.7
47
47
S01GX01
ATC
cromoglicic acid; ophthalmic
2.2
41.5
424
2186
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
40.8
39
*
H16.8
ICD-10 Finland
Other keratitis
204.5
39.0
40
*
L20.0
ICD-10 Finland
Besnier prurigo
3.0
38.2
177
622
F29
ICPC
Eye symptom/complaint other
2.6
36.9
242
1021
H02AB06
ATC
prednisolone; systemic
1.9
36.1
904
6330
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
35.5
34
*
05405
ICD-8 Finland
Herpes simplex, Kerato-conjunctivitis herpetica
125.9
34.8
37
*
XCK10
NOMESCO Finland
Photography of fundus of eye
2.6
34.1
214
882
CG2S4
NOMESCO Finland
Photography of cornea
66.4
34.1
39
6
D06BB03
ATC
aciclovir; topical
3.5
34.0
124
376
F02
ICPC
Red eye
3.5
32.8
115
340
XCH00
NOMESCO Finland
Eye pressure measurement
3.3
32.5
126
397
H01.0
ICD-10 Finland
Blepharitis
2.9
32.5
168
626
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.5
32.2
216
919
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.5
31.6
213
908
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
318.3
30.9
31
*
CD2S4
NOMESCO Finland
Photography of eye
10.8
30.5
33
31
H16.3
ICD-10 Finland
Interstitial and deep keratitis
+∞
30.3
29
*
B00.1
ICD-10 Finland
Herpesviral vesicular dermatitis
7.4
30.2
44
61
D07AA02
ATC
hydrocortisone; topical
2.2
30.0
286
1418
E000002, ,
ATC
2.4
29.4
227
1028
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.8
28.9
593
3832
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
49.5
28.5
34
7
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.5
28.0
185
780
H18.1
ICD-10 Finland
Bullous keratopathy
285.8
27.8
28
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
9.1
27.8
34
38
H10
ICD-10 Finland
Conjunctivitis
2.7
27.4
160
635
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
32.4
26.9
35
11
S01EC04
ATC
brinzolamide; ophthalmic
3.3
25.9
100
314
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
6.0
25.8
46
79
H20.8
ICD-10 Finland
Other iridocyclitis
264.3
25.8
26
*
S01EE01
ATC
latanoprost; ophthalmic
2.7
25.7
144
559
S01BA07
ATC
fluorometholone; ophthalmic
5.7
25.3
47
84
F03
ICPC
Eye discharge
2.6
25.2
152
612
L04AA01
ATC
[U] ciclosporin
6.7
25.2
40
61
114
Kela drug reimbursment
Glaucoma
2.4
24.9
184
815
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
2.5
24.7
159
661
H18.6
ICD-10 Finland
Keratoconus
131.9
24.6
26
*
E0000UV, ,
ATC
1.7
24.6
753
5389
S01EC54
ATC
brinzolamide, combinations; ophthalmic
6.2
24.6
42
69
J01DB01
ATC
cefalexin; oral
1.9
24.4
1471
12655
H26.4
ICD-10 Finland
After-cataract
2.3
24.2
210
997
TCG10
NOMESCO Finland
Removal of sutures from cornea
25.8
24.0
33
13
S05.0
ICD-10 Finland
Injury of conjunctiva and corneal abrasion without mention of foreign body
4.6
23.7
56
124
H26.2
ICD-10 Finland
Complicated cataract
6.1
23.0
40
67
H22.0*B02.3
ICD-10 Finland
Zoster iridocyclitis
+∞
23.0
22
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
45.6
22.4
27
6
S01FA02
ATC
scopolamine; ophthalmic
18.2
22.2
34
19
E000001, ,
ATC
1.8
22.1
364
2172
B00.11
ICD-10 Finland
Herpes simplex labialis
4.6
22.0
52
115
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.6
21.8
134
544
H03.1
ICD-10 Finland
Involvement of eyelid in other infectious diseases classified elsewhere
43.9
21.4
26
6
L04AD01
ATC
ciclosporin; systemic
4.8
21.3
48
102
WX140
NOMESCO Finland
Parabulbar anesthesy
2.8
21.2
106
387
H19.2
ICD-10 Finland
Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
212.4
20.6
21
*
H03.1*B02.3
ICD-10 Finland
Zoster blepharitis
17.1
20.5
32
19
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
5.1
20.5
43
86
S01XA18
ATC
ciclosporin; ophthalmic
7.7
20.0
28
37
H20
ICD-10 Finland
Iridocyclitis
29.3
19.7
26
9
H16
ICD-10 Finland
Keratitis
40.6
19.5
24
6
D07AC01
ATC
betamethasone; topical
1.6
19.4
644
4631
H18.2
ICD-10 Finland
Other corneal oedema
+∞
18.8
18
*
D11AX15
ATC
[U] pimecrolimus
24.0
18.6
26
11
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
191.9
18.6
19
*
R03AC02
ATC
salbutamol; inhalant
1.5
17.8
953
7600
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
17.7
17
*
H3603, E103,
ICD-10 Finland
6.2
17.7
30
49
D07AC13
ATC
mometasone; topical
1.6
17.6
507
3505
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
17.2
834
6488
D11AH02
ATC
pimecrolimus; topical
16.1
17.0
27
17
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
3.6
17.0
57
164
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.1
16.8
180
924
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.0
16.6
193
1020
H40.0
ICD-10 Finland
Glaucoma suspect
2.2
16.4
153
745
F73
ICPC
Eye infection/inflammation other
3.6
16.4
55
158
H10.2
ICD-10 Finland
Other acute conjunctivitis
4.6
16.1
38
84
TQW80
NOMESCO Finland
Local dermatologic skincare
3.3
15.8
59
182
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
15.6
15
*
R06AE07
ATC
cetirizine; oral
1.5
15.5
740
5697
L04AX01
ATC
azathioprine; systemic
2.8
15.5
79
292
H10.5
ICD-10 Finland
Blepharoconjunctivitis
3.7
15.5
48
131
L20
ICD-10 Finland
Atopic dermatitis
3.1
15.4
64
211
H25.1
ICD-10 Finland
Senile nuclear cataract
1.6
15.2
464
3234
E000007, ,
ATC
2.4
15.2
104
445
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
15.1
614
4563
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
5.7
15.1
28
50
S01EX03, ,
ATC
3.8
15.1
46
124
R50.9
ICD-10 Finland
Fever, unspecified
1.7
14.8
274
1677
H13.1
ICD-10 Finland
Conjunctivitis in infectious and parasitic diseases classified elsewhere
57.2
14.8
17
*
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
5.6
14.8
28
51
S01BC05
ATC
ketorolac; ophthalmic
2.8
14.7
76
283
XCK00
NOMESCO Finland
Perimetry
2.3
14.6
111
497
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.8
14.6
234
1374
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
14.6
878
7058
D07AB02
ATC
hydrocortisone butyrate; topical
1.5
14.0
503
3626
S01EE05
ATC
tafluprost; ophthalmic
2.7
14.0
73
273
E000006, ,
ATC
2.2
14.0
126
605
127
Kela drug reimbursment
Transplant complication
4.2
14.0
37
90
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
30.3
13.9
18
6
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
30.3
13.9
18
6
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.8
13.9
219
1279
H02AB07
ATC
prednisone; oral
1.8
13.8
237
1419
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
13.7
340
2247
L04AX03
ATC
methotrexate; systemic
2.0
13.6
166
891
S01EC03
ATC
dorzolamide; ophthalmic
4.5
13.6
33
75
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
13.6
13
*
Z3229
NOMESCO Finland
Other healthcare associate professional
2.0
13.4
146
754
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
4.2
13.2
35
85
N03AX12
ATC
[U] gabapentin; oral
1.7
13.0
278
1767
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.4
12.9
46
138
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.4
12.9
92
401
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.6
12.8
356
2416
S71
ICPC
Herpes simplex
5.4
12.8
25
47
J01MA14
ATC
moxifloxacin; systemic
1.9
12.7
163
890
B02.9
ICD-10 Finland
Zoster without complication
2.1
12.7
131
663
H10.4
ICD-10 Finland
Chronic conjunctivitis
4.7
12.6
29
63
D07AB08
ATC
desonide; topical
1.8
12.6
189
1086
H18.4
ICD-10 Finland
Corneal degeneration
32.3
12.6
16
5
H191, B023,
ICD-10 Finland
+∞
12.5
12
*
CGF35
NOMESCO Finland
Repair of cornea using graft
+∞
12.5
12
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.3
12.5
46
141
S01BC03
ATC
diclofenac; ophthalmic
3.3
12.5
46
141
R03BA05
ATC
fluticasone; inhalant
1.6
12.3
303
1997
J01CA04
ATC
amoxicillin; systemic
1.5
12.2
1382
12358
N02AX02
ATC
tramadol; systemic, rectal
1.4
12.2
724
5739
D02AE01
ATC
carbamide; topical
2.1
12.2
112
543
B00.9
ICD-10 Finland
Herpesviral infection, unspecified
8.7
12.0
25
29
D07CC01
ATC
betamethasone and antibiotics; topical
1.7
11.9
216
1312
J01DA01
ATC
[U] cefalexin
1.4
11.9
1029
8718
N03AX16
ATC
[U] pregabalin
1.5
11.7
381
2677
ZXA10
NOMESCO Finland
Bilateral
1.6
11.6
298
1980
H15.0
ICD-10 Finland
Scleritis
65.4
11.6
13
*
XQ802
NOMESCO Finland
Epicutan test
2.5
11.6
75
313
H190, B005,
ICD-10 Finland
+∞
11.5
11
*
A46
ICD-10 Finland
Erysipelas
1.7
11.4
252
1612
H19.2*B30.0
ICD-10 Finland
Epidemic keratoconjunctivitis
120.8
11.4
12
*
A10AB05
ATC
insulin aspart; parenteral
1.9
11.3
137
734
N02BE01
ATC
paracetamol; systemic, rectal
1.7
11.3
1547
14266
E000004, ,
ATC
3.4
11.3
40
120
L04AA06
ATC
mycophenolic acid; systemic
3.4
11.3
40
120
J01AA02
ATC
doxycycline; systemic
1.5
11.2
1309
11647
H11.1
ICD-10 Finland
Conjunctival degenerations and deposits
8.1
11.1
24
30
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
3.1
11.1
46
152
D07AD01
ATC
clobetasol; topical
1.6
11.0
277
1832
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
2.8
10.9
54
197
A10AA01, ,
ATC
2.9
10.9
50
175
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
10.9
800
6547
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.4
10.8
74
317
S01
ICPC
Pain/tenderness of skin
2.2
10.8
88
407
C03CA01
ATC
furosemide; systemic
1.5
10.8
492
3694
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
10.7
328
2267
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
4.6
10.7
25
55
E000003, ,
ATC
2.3
10.6
79
351
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
10.6
483
3622
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
10.6
238
1530
SPAT1301
SPAT
No procedures
1.4
10.5
498
3765
H40.9
ICD-10 Finland
Glaucoma, unspecified
3.2
10.4
40
126
H17.0
ICD-10 Finland
Adherent leukoma
+∞
10.4
10
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.0
10.3
111
571
F13
ICPC
Eye sensation abnormal
2.6
10.3
59
233
H10.8
ICD-10 Finland
Other conjunctivitis
4.7
10.2
23
49
H02AB04
ATC
methylprednisolone; systemic
1.6
10.2
231
1485
T89
ICPC
Diabetes insulin dependent
2.3
10.2
73
319
J01FA06
ATC
roxithromycin; oral
1.4
10.2
639
5071
R06AE09
ATC
levocetirizine; oral
1.6
10.1
229
1473
B00.0
ICD-10 Finland
Eczema herpeticum
7.9
10.1
22
28
S01FA01
ATC
atropine; ophthalmic
10.1
10.0
19
19
A10AB01
ATC
insulin (human); parenteral
2.5
10.0
61
248
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
10.0
464
3489
B00.19
ICD-10 Finland
Other vesicular dermatitis caused by the herper simplex virus
7.7
9.9
22
29
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.6
9.9
219
1401
J01DA09
ATC
[U] cefadroxil
1.5
9.9
422
3120
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
9.7
623
4954
A10AE04
ATC
insulin glargine; parenteral
1.7
9.6
166
993
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
9.6
365
2636
R42
ICD-10 Finland
Dizziness and giddiness
1.5
9.6
379
2759
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
5.0
9.6
20
40
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
9.6
478
3636
WZC00, ,
SPAT
1.6
9.6
245
1624
CKD40
NOMESCO Finland
Endophotocoagulation of retina
3.7
9.6
30
83
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
9.5
547
4265
D02AX
ATC
Other emollients and protectives
2.6
9.5
54
212
S01AA12
ATC
tobramycin; ophthalmic
15.1
9.5
15
10
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
9.5
222
1439
H18.3
ICD-10 Finland
Changes in corneal membranes
100.6
9.4
10
*
E85.80
ICD-10 Finland
Meretoja sick
+∞
9.4
9
*
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
9.4
9
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
4.4
9.3
23
53
H3601, E103,
ICD-10 Finland
4.9
9.3
20
41
S01EE03
ATC
bimatoprost; ophthalmic
2.7
9.3
47
174
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.4
9.3
464
3527
SPAT1260
SPAT
Consultation of another employee
1.5
9.2
273
1869
A02BC05
ATC
esomeprazole; systemic
1.4
9.2
654
5278
NHQ40
NOMESCO Finland
Amputation of toe
3.3
9.2
34
105
R03DC03
ATC
montelukast; oral
1.5
9.2
268
1830
A02BC02
ATC
pantoprazole; systemic
1.4
9.1
1138
10030
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.9
9.0
114
621
H04AA01
ATC
glucagon; nasal, parenteral
3.0
9.0
39
133
H02AB09
ATC
hydrocortisone; systemic
2.8
8.9
43
155
J45.9
ICD-10 Finland
Asthma, unspecified
1.5
8.9
312
2212
J01FF01
ATC
clindamycin; systemic
1.4
8.9
434
3280
B02.8
ICD-10 Finland
Zoster with other complications
4.9
8.8
19
39
UJF32
NOMESCO Finland
Coloscopy
1.4
8.8
418
3146
N05BB01
ATC
hydroxyzine; systemic
1.9
8.7
104
556
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.7
8.6
148
884
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
2.6
8.6
47
181
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
10.1
8.5
16
16
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
8.5
642
5214
J01FA10
ATC
azithromycin; systemic
1.3
8.5
900
7694
CFD10
NOMESCO Finland
Repair of conjunctiva
20.1
8.5
12
6
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
20.1
8.5
12
6
H22.0
ICD-10 Finland
Iridocyclitis in infectious and parasitic diseases classified elsewhere
90.5
8.4
9
*
S87
ICPC
Dermatitis/atopic eczema
2.7
8.4
45
172
Z3231
NOMESCO Finland
Registered nurse
1.4
8.4
421
3195
H26.02
ICD-10 Finland
Presenil cataract
2.6
8.4
46
178
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
4.9
8.4
18
37
F70
ICPC
Conjunctivitis infectious
2.6
8.4
47
184
3604
FHL
Penetration of the cornea
+∞
8.3
8
*
36400
ICD-8 Finland
Iritis, Iridocyclitis acuta
+∞
8.3
8
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
8.3
299
2131
S29
ICPC
Skin symptom/complaint other
1.5
8.3
329
2390
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.7
8.3
144
864
S01KA02
ATC
hypromellose; ophthalmic
3.1
8.3
33
107
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
4.2
8.2
21
50
R06AX27
ATC
desloratadine; oral
1.4
8.2
439
3369
L88
ICPC
Rheumatoid/seropositive arthritis
2.2
8.2
64
292
D07BC01
ATC
betamethasone and antiseptics; topical
1.6
8.2
186
1198
S01EE04
ATC
travoprost; ophthalmic
2.9
8.1
36
124
R03BA02
ATC
budesonide; inhalant
1.5
8.1
289
2057
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.4
8.1
413
3143
UDC00
NOMESCO Finland
Ear microscopy
1.8
8.0
120
689
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.2
8.0
64
295
M79.6
ICD-10 Finland
Pain in limb
1.3
7.9
712
5920
R06AX13
ATC
loratadine; oral
1.5
7.9
227
1541
R01AD12
ATC
fluticasone furoate; nasal
1.4
7.9
482
3775
L01BA01
ATC
methotrexate; systemic
2.3
7.9
57
251
H33.0
ICD-10 Finland
Retinal detachment with retinal break
2.4
7.9
51
214
XCW10
NOMESCO Finland
Assessment of vision
3.0
7.8
33
111
J01MA02
ATC
ciprofloxacin; systemic
1.3
7.8
611
4979
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
4.2
7.7
20
48
Z01.8
ICD-10 Finland
Other specified special examinations
1.4
7.7
357
2666
R06.0
ICD-10 Finland
Dyspnoea
1.4
7.7
440
3407
S18
ICPC
Laceration/cut
1.3
7.7
768
6475
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.4
7.7
350
2605
L17
ICPC
Foot/toe symptom/complaint
1.4
7.7
489
3854
D06
ICPC
Abdominal pain localized other
1.7
7.7
140
851
H25.8
ICD-10 Finland
Other senile cataract
1.6
7.6
169
1080
H53.1
ICD-10 Finland
Subjective visual disturbances
1.8
7.6
112
640
A07AA02
ATC
nystatin; oral
1.9
7.6
90
480
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.1
7.6
71
348
CKD15
NOMESCO Finland
Injection of vitreous substitute
8.9
7.5
15
17
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
7.5
375
2838
R06AX22
ATC
ebastine; oral
1.5
7.5
265
1881
D09AB01
ATC
zinc bandage without supplements; topical
2.8
7.5
37
136
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
7.4
689
5740
ZXA05
NOMESCO Finland
Left side
1.4
7.4
372
2815
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
80.4
7.4
8
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
80.4
7.4
8
*
A10AE05
ATC
insulin detemir; parenteral
1.9
7.4
87
463
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
13.4
7.4
12
9
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.6
7.3
187
1237
S01GX06
ATC
emedastine; ophthalmic
3.6
7.3
23
64
0544B
ICD-9 Finland
Herpes simplex, With ophthalmic complications[KERATITIS DENDRITICA, HERPETICA]
+∞
7.3
7
*
H19.8*E85.80
ICD-10 Finland
Reticular keratitis in Meretoja's patients
+∞
7.3
7
*
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
7.3
7
*
H00.03
ICD-10 Finland
Preseptal cellulite in the eyelid
6.9
7.3
17
25
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.2
7.3
62
293
H54.4
ICD-10 Finland
Blindness, monocular
9.4
7.3
14
15
SPAT1263
SPAT
Sampling
1.3
7.2
646
5350
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
7.3
7.2
16
22
R52.9
ICD-10 Finland
Pain, unspecified
1.6
7.2
163
1049
R51.80
ICD-10 Finland
Headache
1.5
7.2
244
1718
Z94.0
ICD-10 Finland
Kidney transplant status
3.6
7.1
23
65
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.7
7.1
139
860
H01
ICPC
Ear pain/earache
1.6
7.1
177
1163
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
20.1
7.1
10
5
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.5
7.1
227
1576
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
4.1
7.1
19
47
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.6
7.1
182
1206
P01BA02
ATC
hydroxychloroquine; oral
1.7
7.1
120
716
F05
ICPC
Visual disturbance other
2.2
7.1
55
251
395
Kela drug reimbursment
Dupilumab
8.8
7.0
14
16
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
2.7
7.0
35
129
CHC05
NOMESCO Finland
Iridotomy
3.2
7.0
27
86
R02
ICPC
Shortness of breath/dyspnoea
1.5
7.0
217
1499
R60.9
ICD-10 Finland
Oedema, unspecified
1.9
7.0
91
502
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.6
7.0
40
159
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
1.9
6.9
86
466
A10AA02, ,
ATC
2.2
6.9
53
240
SPAT1325
SPAT
Vaccination
1.3
6.9
496
3973
S01ED02
ATC
betaxolol; ophthalmic
4.0
6.9
19
48
D06BX01
ATC
metronidazole; topical
1.6
6.9
165
1076
SPAT1262
SPAT
Handing over of treatment supplies
1.5
6.9
264
1903
R03AC03
ATC
terbutaline; inhalant
1.5
6.9
215
1488
A01
ICPC
Pain general/multiple sites
1.6
6.8
163
1061
M54.3
ICD-10 Finland
Sciatica
1.8
6.8
97
549
H02.4
ICD-10 Finland
Ptosis of eyelid
2.3
6.8
51
229
S01GX08
ATC
ketotifen; ophthalmic
2.0
6.8
73
377
H43.1
ICD-10 Finland
Vitreous haemorrhage
2.5
6.8
40
161
S01EB01
ATC
pilocarpine; ophthalmic
6.1
6.8
17
28
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
2.2
6.8
52
236
R03AC13
ATC
formoterol; inhalant
1.9
6.8
85
463
CBH25
NOMESCO Finland
Tarsorrhaphy
40.2
6.8
8
*
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
40.2
6.8
8
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
4.3
6.8
17
40
H44.0
ICD-10 Finland
Purulent endophthalmitis
16.8
6.7
10
6
CKA10
NOMESCO Finland
Biopsy of vitreous body
16.8
6.7
10
6
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
2.6
6.7
36
138
ZXE00
NOMESCO Finland
One hour or less
1.3
6.7
588
4845
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.2
6.7
55
257
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.4
6.7
398
3096
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
6.7
128
790
G44.2
ICD-10 Finland
Tension-type headache
1.5
6.6
209
1447
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
2.1
6.6
59
284
X59
ICD-10 Finland
Exposure to unspecified factor
1.4
6.6
291
2150
J46
ICD-10 Finland
Status asthmaticus
2.2
6.6
50
226
WX002
NOMESCO Finland
Sedation and analgesia
1.4
6.5
292
2163
CHD99
NOMESCO Finland
Other filtering operation
10.1
6.5
12
12
P01AB01
ATC
metronidazole; oral, rectal
1.3
6.5
622
5179
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
6.9
6.5
15
22
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
3.7
6.5
20
55
S01GX09
ATC
olopatadine; ophthalmic
2.3
6.5
46
202
J01MA12
ATC
levofloxacin; systemic
1.4
6.5
284
2097
H01.89
ICD-10 Finland
Other specified inflammation of eyelids
5.3
6.5
18
34
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.6
6.5
172
1149
R01AD09
ATC
mometasone; nasal
1.3
6.5
696
5890
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
6.4
692
5854
H19.3
ICD-10 Finland
Keratitis and keratoconjunctivitis in other diseases classified elsewhere
70.1
6.4
7
*
J45
ICD-10 Finland
Asthma
1.6
6.4
161
1061
B30.9
ICD-10 Finland
Viral conjunctivitis, unspecified
7.4
6.4
14
19
R74
ICPC
Upper respiratory infection acute
1.3
6.4
488
3938
H11.3
ICD-10 Finland
Conjunctival haemorrhage
2.0
6.4
66
337
CS494
NOMESCO Finland
Other visual field testing
2.3
6.4
44
191
J45.8
ICD-10 Finland
Mixed asthma
2.2
6.4
51
236
C10AA05
ATC
atorvastatin; oral
1.3
6.3
662
5575
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
8.2
6.3
13
16
D64.9
ICD-10 Finland
Anaemia, unspecified
1.5
6.3
168
1122
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
2.5
6.3
39
161
05403
ICD-8 Finland
Herpes simplex, Cutaneus (Eczema herpeticum)
+∞
6.3
6
*
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
+∞
6.3
6
*
3619
FHL
Other operations in this group, such as corneal refractive surgery
+∞
6.3
6
*
36398
ICD-8 Finland
Keratitis, Alia definita
+∞
6.3
6
*
H21.0
ICD-10 Finland
Hyphaema
+∞
6.3
6
*
H05.0
ICD-10 Finland
Acute inflammation of orbit
26.8
6.2
8
*
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
3.7
6.2
19
52
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
2.3
6.2
43
187
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.5
6.2
190
1309
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
1.9
6.2
80
441
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.4
6.2
272
2010
Z71.8
ICD-10 Finland
Other specified counselling
1.3
6.2
523
4280
K86.1
ICD-10 Finland
Other chronic pancreatitis
3.8
6.1
18
48
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
3.8
6.1
18
48
SPAT1312
SPAT
General health counselling
1.3
6.1
465
3749
R03AC12
ATC
salmeterol; inhalant
1.9
6.1
68
357
H40.8
ICD-10 Finland
Other glaucoma
6.7
6.0
14
21

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
72
35
21.40
95.64
1.4
1.6
—
—
—
0
0
418
1864
2.62
58.82
2.2
1.7
—
—
—
0
0
1024
8006
1.66
23.30
8.6
6.1
0.04
0.04
e9/l
0.00
918
6874
1022
7992
1.66
23.19
8.5
6.1
0.60
0.58
e9/l
1.51
916
6865
1041
8183
1.66
23.10
8.6
6.2
1.80
1.93
e9/l
2.52
945
7202
1046
8266
1.65
22.43
8.7
6.4
0.20
0.19
e9/l
1.44
945
7205
1113
8999
1.63
21.18
12.4
9.6
4.23
4.14
e9/l
0.60
1002
7830
946
7362
1.61
20.99
8.8
6.3
0.69
0.68
%
0.18
906
6902
946
7368
1.61
20.87
8.7
6.3
3.00
2.84
%
1.34
908
6918
947
7380
1.61
20.82
8.7
6.4
8.98
8.86
%
0.65
912
6929
964
7566
1.60
20.40
8.5
6.3
26.58
27.38
%
1.64
935
7192
950
7431
1.60
20.39
8.4
6.1
58.22
57.62
%
0.88
930
7112
29
41
7.17
19.53
1.2
1.5
—
—
—
0
0
1374
11932
1.67
17.65
10.8
8.3
81.48
79.06
u/l
0.74
1325
11341
903
7137
1.54
17.39
6.6
5.1
35.34
35.56
g/l
0.56
859
6691
704
5280
1.55
17.14
8.3
6.2
—
—
—
0
0
983
8018
1.51
15.61
9.1
7.3
1.21
1.21
mmol/l
0.16
870
6930
1315
11438
1.58
15.28
6.0
4.2
13.23
12.25
mm/h
1.52
1246
10686
607
4493
1.53
15.24
5.7
4.3
—
—
—
0
0
665
5046
1.51
14.73
3.4
2.6
53.53
75.89
u/l
0.80
623
4695
445
3111
1.57
14.27
1.7
1.5
2.69
2.48
g/l
0.84
299
1928
491
3538
1.54
13.67
6.1
4.6
—
—
—
0
0
1006
8375
1.46
13.54
5.0
3.9
0.03
0.19
estimate
0.42
228
1664
999
8324
1.46
13.26
5.0
3.9
6.11
5.67
estimate
0.02
247
1776
349
2351
1.60
12.97
2.8
2.1
—
—
—
0
0
564
4224
1.49
12.93
2.7
2.3
2.91
2.87
mg/l
0.18
510
3623
851
6905
1.45
12.85
15.6
11.4
0.00
0.00
e9/l
1.69
720
5649
32
75
4.33
12.68
1.2
1.2
—
—
—
0
0
984
8215
1.44
12.67
5.0
3.9
0.00
0.00
estimate
0.50
243
1742
639
4921
1.47
12.66
2.3
2.2
153.79
227.06
u/l
1.79
606
4661
53
178
3.04
12.39
1.1
1.2
—
—
—
0
0
35
92
3.86
11.93
2.9
2.3
216.11
227.66
e6/l
0.14
27
83
1088
9307
1.44
11.92
6.3
5.2
6.76
6.72
mmol/l
0.19
1047
8839
891
7375
1.42
11.60
16.8
15.5
1.25
1.26
inr
0.25
763
6155
385
2722
1.53
11.42
3.4
2.6
12.83
13.01
umol/l
0.12
360
2533
340
2339
1.56
11.41
3.4
2.6
22.82
22.91
%
0.02
318
2181
1171
10193
1.44
11.38
5.7
4.8
3440.19
1830.15
e6/l
0.44
23
142
898
7461
1.41
11.34
3.8
3.1
129.65
126.62
ug/l
0.15
839
6953
734
5897
1.42
11.18
5.1
4.0
76.09
111.01
e6/l
0.92
550
4168
657
5177
1.43
11.16
4.4
3.4
65.68
86.28
e6/l
0.32
531
3968
361
2529
1.54
11.14
3.3
2.5
2.34
2.30
g/l
0.72
337
2338
33
88
3.80
11.04
2.9
2.1
504.88
603.47
e6/l
0.38
24
75
480
3582
1.47
10.86
3.6
2.7
4.69
5.92
e6/l
1.28
449
3266
989
8416
1.39
10.53
7.9
6.7
11.57
11.57
umol/l
0.00
957
8042
236
1520
1.64
10.39
2.6
2.1
338.63
381.99
nmol/l
2.92
223
1405
611
4802
1.42
10.34
5.6
4.1
7.40
7.40
ph
0.97
466
3438
806
6642
1.39
10.32
4.3
3.5
6.25
6.23
ph
0.18
440
3741
39
123
3.22
10.16
2.8
2.1
1191.81
1228.00
e6/l
0.10
31
113
609
4819
1.40
9.78
3.4
3.2
1534.71
1335.96
ng/l
0.50
527
4135
474
3590
1.44
9.75
1.4
1.3
2.73
1.53
u/ml
0.98
139
995
667
5368
1.39
9.66
3.5
3.3
30.81
33.40
u/l
1.14
640
5071
214
1372
1.64
9.57
2.8
2.8
66.08
66.72
g/l
0.65
203
1265
462
3502
1.43
9.41
1.8
1.7
1.12
1.24
mg/l
0.37
358
2696
1318
11890
1.42
9.27
5.1
4.4
14.63
14.79
pmol/l
1.69
1224
10952
212
1369
1.62
9.21
4.8
4.3
0.61
0.71
%
0.38
61
410
580
4591
1.39
9.17
5.2
4.0
0.00
0.01
estimate
1.54
225
1617
160
961
1.73
9.15
2.2
1.8
1.14
1.43
g/l
1.74
149
893
270
1852
1.54
9.04
3.1
2.6
1.86
1.80
%
0.45
255
1652
609
4872
1.38
8.99
3.7
3.2
—
—
—
0
0
125
702
1.84
8.96
1.3
1.2
—
—
—
0
0
566
4476
1.39
8.95
4.5
3.3
0.02
0.08
estimate
0.71
204
1383
170
1046
1.69
8.90
1.9
1.3
1590.46
184.43
u/ml
1.48
155
968
840
7085
1.35
8.79
2.2
2.1
96.56
95.71
pmol/l
0.22
461
3788
753
6261
1.35
8.59
5.0
3.8
0.01
0.03
estimate
0.52
207
1443
524
4117
1.39
8.55
3.3
2.8
340.67
343.63
umol/l
0.28
467
3626
209
1382
1.58
8.21
5.2
4.6
0.02
0.14
%
4.71
59
379
278
1957
1.50
8.21
1.8
1.4
—
—
—
0
0
558
4454
1.37
8.19
4.4
3.3
0.46
0.46
e6/l
0.02
437
3278
188
1213
1.61
8.18
3.7
2.8
10.44
10.82
g/l
0.53
180
1121
23
59
3.94
8.16
32.6
32.7
110.71
119.53
ug/l
0.32
18
49
243
1665
1.53
8.15
4.9
3.6
7.36
7.38
ph
0.56
163
972
216
1445
1.56
8.06
5.2
4.5
0.70
1.02
%
1.38
66
441
408
3099
1.41
8.05
4.1
2.9
534.76
527.67
mosm/kgh2o
0.26
379
2722
213
1422
1.57
8.02
2.8
2.7
73.27
69.97
e9/l
0.68
156
1055
846
7206
1.33
8.02
8.2
6.6
1.21
1.21
mmol/l
0.08
804
6655
434
3344
1.39
7.85
1.8
1.7
76882169.65
30728291.45
pmol/l
0.48
372
2789
20
33
6.12
7.84
3.4
1.7
0.15
0.19
e9/l
0.21
11
14
676
5585
1.34
7.84
3.8
3.6
2.35
2.35
mmol/l
0.86
631
5075
1595
15056
1.58
7.81
24.1
16.2
22.96
24.53
mg/l
1.17
1412
12436
67
318
2.15
7.77
4.1
2.5
16.47
16.26
%
0.22
67
313
298
2152
1.46
7.72
1.6
1.3
642.39
485.69
titre
0.60
67
464
207
1390
1.55
7.59
5.5
4.8
0.06
0.35
%
0.66
51
347
171
1102
1.61
7.48
2.6
2.5
—
—
—
0
0
567
4600
1.34
7.32
1.8
1.7
20.39
20.26
nmol/l
0.06
514
3917
58
267
2.21
7.27
4.3
3.2
4.36
4.29
e9/l
0.10
58
267
629
5194
1.33
7.16
4.4
3.5
57.62
48.94
mg/l
0.29
435
3362
231
1614
1.50
7.04
5.0
3.5
1.99
1.83
mmol/l
0.24
200
1377
129
788
1.69
6.96
1.4
1.2
—
—
—
0
0
110
643
1.76
6.95
1.3
1.4
—
12.97
—
0
16
97
547
1.82
6.91
1.2
1.2
—
—
—
0
0
53
241
2.24
6.86
2.5
1.8
1.54
1.74
mmol/l
1.06
53
235
719
6077
1.31
6.84
4.6
3.8
39.65
67.94
ng/l
1.02
514
4308
1502
14081
1.43
6.82
6.2
5.4
1.91
1.92
mu/l
0.12
1418
13044
636
5293
1.31
6.75
5.1
4.2
9.45
9.04
mg/mmol
0.08
440
3342
660
5522
1.31
6.74
4.5
3.4
7.39
7.54
mmol/l
0.38
575
4705
295
2183
1.42
6.65
1.3
1.2
—
—
—
0
0
357
2732
1.38
6.61
3.7
3.3
0.81
0.82
mmol/l
0.15
342
2588
32
117
2.77
6.55
1.3
1.2
—
—
—
0
0
1616
15405
1.54
6.36
26.3
19.4
3.98
3.97
mmol/l
0.67
1596
15085
833
7229
1.29
6.32
2.7
2.4
76.77
77.18
nmol/l
0.17
785
6537
185
1266
1.51
6.22
5.4
3.9
—
—
—
0
0
1612
15374
1.52
6.16
26.0
19.2
139.45
139.65
mmol/l
2.72
1593
15087
144
936
1.59
6.10
3.1
3.5
4.48
4.53
pmol/l
0.26
133
836
411
3260
1.34
6.00
3.5
3.1
2.45
2.45
mmol/l
0.26
373
2932
1153
10464
1.29
5.99
4.1
3.3
52.93
48.82
u/l
0.80
1107
9859
245
1787
1.43
5.96
1.4
1.3
—
—
—
0
0
194
1353
1.49
5.96
2.3
2.4
6.28
7.39
ug/l
0.35
166
1211
263
1943
1.41
5.96
2.7
2.4
146.98
124.50
ug/g
0.41
211
1559
95
561
1.73
5.84
3.9
3.0
25.12
24.95
mmol/l
0.18
95
552
210
1498
1.46
5.75
10.2
7.1
11.04
9.83
mmol/l
1.48
203
1441
73
401
1.86
5.71
4.0
3.0
8.33
8.04
kpa
0.90
73
394
104
638
1.67
5.57
2.2
1.8
3.65
6.68
iu/ml
1.56
20
144
1536
14565
1.40
5.56
5.5
5.1
6.03
5.95
mmol/l
1.46
1426
13397
65
348
1.90
5.51
4.1
3.0
91.21
89.72
%
0.99
65
336
388
3090
1.33
5.46
4.3
3.9
550.28
433.42
ng/l
0.19
299
2404
63
336
1.91
5.40
4.2
3.1
57.40
59.00
%
0.45
63
336
320
2488
1.35
5.28
2.4
2.0
29.57
29.52
s
0.05
314
2418
21
69
3.07
5.22
1.7
2.8
835.43
1319.75
u/ml
0.58
21
69
198
1427
1.44
5.14
7.9
9.3
—
—
—
0
0
151
1032
1.51
5.13
4.4
3.9
7.42
7.42
ph
0.12
133
879
631
5394
1.26
5.09
4.6
3.6
—
0.71
—
0
17
46
225
2.07
5.04
4.0
2.5
—
—
—
0
0
1645
15842
1.52
5.04
16.2
12.1
26.13
26.03
u/l
0.08
1610
15431
1658
15997
1.54
5.00
29.3
21.1
80.30
77.71
umol/l
2.09
1647
15825
45
220
2.07
4.95
1.7
2.3
—
4.80
—
0
5
285
2199
1.35
4.93
8.4
5.7
1.05
1.03
mmol/l
0.62
265
2038
343
2726
1.32
4.85
1.7
1.8
1195.22
1190.61
nmol/l
0.03
260
2066
113
737
1.57
4.76
1.9
1.9
1.49
1.50
g/l
0.01
101
643
1688
16378
1.61
4.66
34.8
25.1
39.95
40.25
%
1.48
1679
16204
55
296
1.89
4.64
2.0
1.4
—
—
—
0
0
364
2934
1.30
4.63
1.4
1.3
36.04
31.52
iu/ml
0.21
120
897
1688
16382
1.61
4.60
34.4
24.7
6.85
6.79
e9/l
0.41
1664
16021
1563
14956
1.37
4.53
5.6
5.1
4.50
4.62
mmol/l
5.04
1463
14003
1687
16375
1.60
4.53
34.3
24.6
91.46
91.16
fl
1.81
1679
16210
1687
16378
1.59
4.49
34.2
24.5
30.38
30.33
pg
0.42
1678
16212
1687
16378
1.59
4.49
34.4
24.6
4.44
4.48
e12/l
2.02
1663
16018
57
314
1.84
4.48
5.7
4.5
2.21
2.75
mmol/l
0.78
39
207
252
1936
1.35
4.48
7.2
8.3
7.41
7.41
ph
0.34
146
1073
57
315
1.84
4.44
5.7
4.5
8.71
8.52
kpa
0.42
57
309
57
315
1.84
4.44
5.7
4.5
4.92
5.04
kpa
0.67
57
309
1686
16371
1.58
4.42
34.5
24.7
252.66
250.26
e9/l
0.76
1665
16062
1687
16383
1.59
4.42
34.7
24.8
133.76
134.87
g/l
2.38
1678
16220
76
458
1.69
4.41
3.3
2.3
4521.28
5346.06
u/l
0.13
29
205
522
4426
1.25
4.39
3.6
3.0
0.19
0.02
0.62
16
105
206
1544
1.38
4.28
1.6
1.5
—
—
—
0
0
170
1235
1.42
4.24
1.2
1.2
—
—
—
0
0
81
502
1.64
4.24
5.4
3.1
1.64
1.58
mg/l
0.22
75
457
74
448
1.68
4.23
2.1
1.6
0.23
0.24
g/l
0.29
74
426
1497
14271
1.31
4.15
7.7
6.4
40.74
39.39
mmol/mol
4.31
1409
13377
1579
15171
1.37
4.13
6.3
5.8
2.57
2.70
mmol/l
6.74
1474
14145
343
2785
1.29
4.10
3.6
3.0
1.23
1.28
e6/l
0.08
183
1494
21
80
2.64
4.07
1.1
1.0
1481.72
1502.26
miu/ml
0.03
21
80
247
1922
1.33
4.03
7.2
8.2
1.55
0.98
mmol/l
1.52
202
1589
167
1227
1.40
3.92
4.0
3.0
171.83
197.87
ng/l
0.50
150
1122
14
43
3.27
3.91
4.7
4.3
—
—
—
0
0
205
1559
1.36
3.90
2.3
2.2
0.20
0.21
g/l
1.20
191
1450
14
38
3.71
3.79
2.6
3.1
5.14
5.60
ug/l
0.08
14
38
34
167
2.06
3.76
2.1
2.0
21.94
7.93
umol/l
0.65
26
119
1549
14877
1.32
3.75
5.5
5.0
1.44
1.46
mmol/l
0.86
1444
13837
47
260
1.83
3.70
1.9
1.7
1.52
0.81
g/l
0.67
34
209
31
148
2.11
3.69
1.6
1.3
7.43
6.92
g/l
0.23
21
110
31
148
2.11
3.69
1.6
1.3
3.41
2.89
g/l
0.55
21
111
31
148
2.11
3.69
1.6
1.4
—
—
—
0
0
31
148
2.11
3.69
1.6
1.3
0.41
0.39
g/l
0.11
21
110
335
2748
1.27
3.67
1.4
1.3
11.06
10.96
u/ml
0.01
124
1053
246
1942
1.31
3.63
7.3
8.2
5.14
5.13
kpa
0.11
239
1874
194
1480
1.35
3.62
2.2
2.2
0.00
0.02
estimate
0.78
46
305
246
1943
1.31
3.61
7.3
8.2
11.79
12.17
kpa
0.63
239
1879
37
194
1.93
3.45
1.4
2.0
—
1474.29
—
0
7
827
7497
1.19
3.35
3.2
2.8
—
—
estimate
—
0
0
440
3762
1.23
3.30
4.5
3.8
0.00
0.08
—
6
38
168
1274
1.35
3.28
5.1
3.7
1.22
1.23
mmol/l
0.32
150
1077
47
271
1.75
3.27
2.0
1.4
146.24
167.73
au/ml
0.73
14
76
1327
12578
1.22
3.21
27.2
20.0
13.84
13.65
%
5.70
1314
12416
28
138
2.05
3.12
1.4
1.1
—
—
—
0
0
551
4840
1.20
3.11
5.7
5.5
2.32
2.61
ug/l
0.39
501
4378
12
35
3.44
3.10
1.8
1.5
—
—
—
0
0
40
224
1.80
3.08
2.8
2.6
—
—
—
0
0
27
132
2.06
3.07
1.3
1.2
121.89
106.36
pmol/l
0.60
27
132
35
188
1.88
3.07
3.9
2.5
1.21
1.19
mmol/l
1.20
35
188
25
119
2.12
3.04
2.8
2.4
852.40
643.89
ml
2.76
15
81
172
1325
1.33
3.03
2.9
2.4
0.28
0.50
e6/l
1.49
165
1263
463
4010
1.21
3.03
2.8
2.4
—
—
—
0
0
695
6246
1.19
3.02
2.3
2.2
—
—
—
0
0
15
57
2.65
2.96
1.8
1.2
33.01
32.46
nmol/l
0.02
15
46
332
2787
1.24
2.95
2.2
1.9
—
—
—
0
0
106
759
1.42
2.94
2.4
2.2
0.00
1.08
estimate
0.50
37
233
42
243
1.75
2.92
2.4
4.2
1.35
1.42
%
0.05
37
223
160
1228
1.33
2.90
2.4
2.6
6.06
6.07
ph
0.07
106
841
35
192
1.84
2.89
3.9
2.5
4.06
4.08
mmol/l
0.14
35
192
35
192
1.84
2.89
3.9
2.5
105.66
105.34
mmol/l
0.16
35
192
228
1841
1.27
2.84
3.6
2.7
11.27
7.68
umol/l
0.89
204
1632
124
1650
0.73
2.84
2.0
2.0
3.40
3.51
ratio
0.47
98
1302
1477
14207
1.23
2.81
4.7
4.3
1.31
1.29
mmol/l
0.80
1363
13086
23
110
2.11
2.79
1.0
1.0
—
—
—
0
0
55
347
1.60
2.78
6.5
3.8
—
—
—
0
0
592
5277
1.18
2.78
3.0
2.5
—
—
—
0
0
21
97
2.18
2.77
1.0
1.0
—
—
—
0
0
25
124
2.03
2.76
1.3
1.5
17.65
30.18
%
1.39
17
73
76
519
1.49
2.71
5.2
3.7
7.41
7.41
ph
0.06
76
513
66
439
1.52
2.67
1.4
1.2
23.11
2.24
u/ml
—
10
37
422
3665
1.20
2.65
4.8
4.1
1.02
1.02
kg/l
0.21
292
2427
533
4729
1.18
2.62
8.1
6.2
—
—
—
0
0
242
1990
1.25
2.60
4.1
3.3
4.66
4.76
e9/l
0.05
222
1738
1594
15492
1.28
2.59
20.1
14.6
—
—
—
0
0
40
237
1.70
2.59
2.7
2.1
0.95
0.88
%
0.33
29
166
194
1556
1.28
2.57
3.5
2.5
35.76
71.84
u/l
0.61
160
1321
208
1683
1.27
2.56
3.7
4.5
5.48
18.75
ug/l
1.69
171
1391
58
379
1.55
2.56
6.7
4.3
—
—
—
0
0
21
101
2.09
2.53
2.6
2.9
40.92
38.76
%
0.15
12
52
71
487
1.48
2.50
1.7
1.5
213.21
281.59
ug/g
2.22
42
292
59
390
1.53
2.48
3.3
2.2
125.51
128.91
g/l
0.48
45
310
161
1267
1.30
2.47
5.0
3.8
98.57
88.88
ng/l
0.68
144
1102
72
497
1.47
2.46
1.1
1.1
—
—
—
0
0
99
726
1.39
2.44
4.1
4.0
—
—
—
0
0
303
2570
1.22
2.43
3.9
3.2
3.39
2.58
e6/l
0.44
149
1278
65
441
1.49
2.43
1.4
1.2
12.83
8.08
u/ml
0.17
12
63
151
1183
1.30
2.41
1.5
1.5
—
—
—
0
0
47
297
1.60
2.40
1.5
1.2
257.19
250.20
u/ml
0.06
36
174
105
782
1.36
2.36
4.7
3.5
1.02
1.02
ratio
1.20
93
714
8
22
3.65
2.36
1.5
1.1
—
—
—
0
0
8
22
3.65
2.36
1.5
1.1
—
—
—
0
0
8
22
3.65
2.36
1.5
1.1
—
—
—
0
0
13
52
2.51
2.36
2.5
1.6
—
—
—
0
0
29
161
1.81
2.36
1.1
1.2
—
—
—
0
0
11
39
2.83
2.34
1.2
1.1
—
—
—
0
0
215
1769
1.25
2.31
1.9
1.6
—
—
—
0
0
457
4044
1.18
2.29
5.0
4.1
88.99
89.45
%
0.15
444
3965
85
615
1.40
2.28
2.9
2.7
—
—
—
0
0
43
271
1.60
2.24
1.1
1.1
34.39
18.87
au/ml
—
10
71
35
209
1.69
2.24
1.9
1.5
—
—
—
0
0
35
209
1.69
2.24
1.9
1.5
—
—
—
0
0
35
209
1.69
2.24
1.9
1.5
—
—
—
0
0
35
209
1.69
2.24
1.9
1.5
—
—
—
0
0
13
54
2.42
2.20
3.2
1.8
—
—
—
0
0
137
1075
1.30
2.18
1.2
1.2
95.33
131.33
u/ml
0.75
48
421
6
14
4.30
2.15
1.7
1.3
54.67
47.64
umol/l
—
6
14
9
30
3.01
2.14
1.7
1.7
—
—
—
0
0
134
1053
1.29
2.11
2.1
2.5
51.12
19.70
au/ml
—
9
107
18
88
2.06
2.11
3.3
2.4
511.00
503.06
min
0.18
11
67
51
340
1.51
2.10
1.3
1.2
—
—
—
0
0
1314
12605
1.16
2.09
28.4
20.8
331.64
332.21
g/l
1.53
1309
12538
141
1122
1.28
2.03
8.1
10.1
1.24
1.31
%
0.54
141
1117
57
394
1.46
1.99
1.1
1.1
6.91
7.74
eliau/ml
—
7
47
31
186
1.68
1.98
1.6
1.3
101.00
61.46
u/ml
—
5
10
73
531
1.39
1.94
2.1
1.7
294.79
294.45
mu/l
0.00
66
480
246
2092
1.20
1.94
1.4
1.3
—
—
—
0
0
33
203
1.64
1.93
1.2
1.3
442.93
332.50
pmol/l
0.87
28
179
273
2349
1.19
1.90
2.0
1.6
—
—
—
0
0
28
166
1.70
1.88
1.9
1.6
38.00
32.20
ng/l
0.13
28
166
701
6477
1.14
1.88
2.1
1.9
1.39
1.35
mmol/l
0.61
591
5481
9
34
2.66
1.86
1.3
1.2
—
—
—
0
0
61
435
1.42
1.83
1.1
1.2
—
—
—
0
0
169
1393
1.24
1.82
1.9
1.7
—
—
—
0
0
95
1225
0.76
1.82
1.7
1.8
3.42
3.50
mmol/l
0.27
67
880
66
479
1.39
1.80
3.5
3.5
1.20
3.05
ratio
1.62
32
274
9
35
2.58
1.80
2.8
2.9
—
42.69
—
0
8
26
153
1.71
1.80
2.7
2.4
—
—
—
0
0
51
353
1.46
1.80
4.4
2.9
40.09
34.65
umol/l
0.48
44
310
24
138
1.75
1.79
2.2
1.2
4.74
0.70
u/ml
1.19
18
76
8
29
2.77
1.79
1.4
1.3
—
218.00
—
0
5
48
329
1.47
1.78
3.5
1.9
0.81
0.87
nmol/l
0.25
41
274
59
421
1.42
1.77
1.1
1.1
—
—
—
0
0
30
185
1.63
1.76
1.5
1.4
—
—
nmol/l
—
0
0
17
89
1.92
1.70
1.3
1.5
1.18
1.26
nmol/l
0.09
12
65
72
537
1.36
1.68
4.2
3.7
42.79
61.45
mg/l
0.89
57
464
72
538
1.35
1.66
4.2
3.7
39.34
70.31
mg/l
0.77
57
465
6
19
3.16
1.66
1.3
1.1
0.11
0.06
u/ml
—
6
19
49
343
1.44
1.65
1.9
1.6
—
—
—
0
0
159
1320
1.22
1.63
2.8
2.4
13.49
12.90
nmol/l
0.34
146
1204
137
1121
1.24
1.61
8.3
10.3
92.76
93.83
%
0.82
137
1116
20
113
1.78
1.60
1.3
1.4
15.70
13.31
u/l
0.52
20
108
51
363
1.42
1.58
3.3
2.4
198.84
107.14
ug/min
0.73
28
227
85
657
1.31
1.58
1.9
1.7
0.38
0.34
mg/l
0.17
39
307
64
476
1.36
1.54
1.4
1.2
—
—
—
0
0
5
15
3.34
1.52
4.6
2.5
0.88
0.59
ug/l
—
5
15
5
15
3.34
1.52
1.0
2.9
—
—
—
0
0
79
608
1.31
1.52
2.1
1.9
21.29
20.83
s
0.37
69
550
32
210
1.53
1.49
1.4
1.4
0.66
9.02
nmol/l
0.50
32
203
33
219
1.52
1.46
1.4
1.4
0.10
0.38
nmol/l
—
5
19
99
790
1.27
1.46
2.4
2.4
—
—
—
0
0
58
430
1.36
1.44
2.1
2.1
2.21
17.17
iu/l
0.60
21
179
5
16
3.13
1.44
1.6
1.7
—
—
—
0
0
28
180
1.56
1.43
3.2
2.3
0.95
0.67
mmol/l
0.16
28
175
9
39
2.31
1.43
1.0
1.1
17.41
16.54
umol/l
—
9
32
18
104
1.74
1.37
1.3
1.4
88.33
84.18
umol/l
0.10
18
104
34
232
1.47
1.34
3.4
2.3
—
—
—
0
0
10
47
2.13
1.33
1.0
1.1
—
—
—
0
0
51
376
1.37
1.33
2.5
1.8
186.45
209.24
pmol/l
0.90
51
355
29
192
1.52
1.32
2.7
2.3
1.31
1.42
g/24h
0.08
18
114
6
24
2.50
1.30
2.3
5.5
8.70
8.10
mmol/l
—
6
24
9
43
2.10
1.30
2.4
2.7
—
—
—
0
0
10
48
2.09
1.27
1.0
1.0
—
—
—
0
0
70
546
1.29
1.26
2.6
1.8
—
—
—
0
0
14
78
1.80
1.21
1.0
1.0
2.98
0.42
u/ml
—
7
18
159
1364
1.18
1.20
1.5
1.4
—
—
—
0
0
65
506
1.30
1.20
2.7
1.9
—
—
—
0
0
22
140
1.58
1.20
1.1
1.1
—
—
—
0
0
70
551
1.28
1.19
2.6
1.8
—
—
—
0
0
70
551
1.28
1.19
2.6
1.8
—
—
—
0
0
11
57
1.94
1.17
2.2
2.0
7337.80
32850.11
e6/l
—
5
35
10
50
2.01
1.16
1.0
1.1
—
—
—
0
0
0
35
0.00
1.15
0.0
1.3
—
25.19
—
0
26
13
72
1.81
1.15
1.4
3.0
182.29
111.29
umol/l
—
7
42
70
555
1.27
1.14
2.7
1.8
—
—
—
0
0
14
80
1.76
1.13
1.0
1.0
9.68
1.04
u/ml
—
8
30
11
58
1.90
1.12
1.8
2.1
0.00
0.05
estimate
0.49
11
58
23
152
1.52
1.09
3.0
4.7
—
—
—
0
0
8
41
1.96
1.09
2.4
1.5
0.44
0.50
e9/l
—
8
41
319
2901
1.12
1.08
3.2
3.3
0.81
0.77
ug/l
0.35
205
1856
23
153
1.51
1.06
4.0
3.5
18.00
11.90
index
0.80
11
87
36
262
1.38
1.06
1.7
1.7
—
—
—
0
0
35
254
1.39
1.05
1.2
1.1
—
—
—
0
0
38
280
1.36
1.04
1.3
1.1
—
—
—
0
0
38
280
1.36
1.04
1.3
1.1
—
—
—
0
0
166
1894
0.86
1.03
5.6
4.9
33.50
32.33
%
0.74
119
1259
174
1525
1.16
1.03
1.6
1.4
—
—
—
0
0
13
75
1.74
1.02
1.1
1.2
30.15
28.45
umol/l
0.35
13
67
10
53
1.89
1.01
2.9
2.6
0.60
0.61
mmol/l
—
10
53
12
68
1.77
1.00
2.3
2.2
622.57
866.15
e6/l
—
7
55
70
566
1.25
0.99
3.7
4.1
24.64
24.95
mmol/l
0.43
65
523
9
50
1.80
0.96
2.4
2.1
25.56
31.16
%
—
9
50
27
191
1.42
0.95
1.3
1.3
—
—
—
0
0
70
572
1.23
0.92
1.7
1.6
21.23
13.73
u/ml
0.62
16
132
51
402
1.28
0.91
1.8
1.6
11972.57
12630.94
e6/l
0.04
40
284
626
5933
1.09
0.91
3.7
3.2
—
—
—
0
0
53
420
1.27
0.91
1.3
1.1
—
—
—
0
0
26
185
1.41
0.89
1.5
1.4
0.20
0.28
nmol/l
0.39
19
145
10
57
1.76
0.83
1.3
1.2
—
—
—
0
0
46
364
1.27
0.81
1.4
1.5
24.24
7.07
e6/l
0.43
33
273
12
73
1.65
0.81
1.0
1.0
0.70
0.25
u/ml
—
5
14
0
24
0.00
0.79
0.0
1.2
—
1.87
—
0
24
68
566
1.21
0.78
3.4
3.5
767.65
317.61
mg/l
0.77
31
249
28
208
1.35
0.77
1.0
1.1
4.94
1.82
eliau/ml
0.71
12
93
55
449
1.23
0.76
3.3
3.3
4.55
1.79
index
1.01
22
232
0
28
0.00
0.76
0.0
1.1
—
2.66
—
0
23
54
441
1.23
0.75
1.6
1.4
10.27
9.07
u/l
0.27
43
353
12
75
1.60
0.75
2.2
1.6
—
—
—
0
0
46
369
1.25
0.75
1.5
1.6
1365.12
670.45
e6/l
0.38
34
290
41
325
1.27
0.73
2.2
1.8
—
—
—
0
0
42
334
1.26
0.73
1.4
1.5
—
—
—
0
0
5
25
2.00
0.72
1.0
1.0
10.25
6.66
mg/g
—
5
25
34
264
1.29
0.71
1.0
1.1
9.61
5.01
u/ml
0.57
22
140
46
373
1.24
0.69
2.3
2.5
—
—
—
0
0
14
93
1.51
0.69
2.6
2.6
15.66
15.99
%
0.17
14
93
5
27
1.85
0.68
1.0
1.1
10.36
0.62
u/ml
—
5
21
5
27
1.85
0.68
1.0
1.0
—
—
—
0
0
11
69
1.60
0.68
1.2
1.1
158.45
194.17
iu/ml
0.29
11
69
26
196
1.33
0.67
1.4
1.3
277.85
277.43
mosm/kgh2o
0.03
20
148
13
86
1.52
0.66
14.4
13.1
0.74
0.64
mmol/l
0.27
13
79
18
128
1.41
0.65
1.4
1.4
8.94
9.00
mmol/l
0.02
18
123
166
1505
1.11
0.64
5.5
4.5
7.38
7.36
ph
1.17
129
1090
22
163
1.35
0.64
1.5
2.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
1367.88
—
0
16
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
11
162
0.68
0.58
2.5
2.3
—
—
—
0
0
52
437
1.20
0.58
3.1
1.8
—
—
—
0
0
56
474
1.19
0.58
10.5
10.1
—
—
—
0
0
21
158
1.33
0.57
1.1
1.1
—
—
—
0
0
32
256
1.25
0.57
1.0
1.1
3.59
1.39
u/ml
0.38
17
105
22
167
1.32
0.57
1.4
1.7
65.07
58.88
%
0.35
15
107
6
36
1.67
0.56
1.5
1.2
—
—
—
0
0
42
347
1.22
0.56
2.4
3.7
16.09
1195.06
u/ml
0.96
36
324
9
61
1.48
0.53
1.1
1.2
—
0.12
g/l
—
0
5
22
169
1.31
0.53
1.6
1.7
—
—
—
0
0
14
101
1.39
0.49
1.4
1.3
—
—
—
0
0
7
45
1.56
0.49
1.1
1.7
108.71
700.16
nmol/24h
—
7
45
23
181
1.27
0.48
1.7
1.5
—
—
—
0
0
14
102
1.38
0.47
2.2
2.5
8.04
8.41
mmol/l
0.20
14
102
31
254
1.22
0.47
1.1
1.1
1.68
1.65
u/ml
0.02
22
125
30
245
1.23
0.47
1.7
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
17.12
—
0
8
35
412
0.85
0.41
1.3
1.3
—
—
—
0
0
8
59
1.36
0.41
2.6
2.4
15.55
163.41
ug/l
—
8
49
23
282
0.81
0.40
1.7
1.6
—
—
—
0
0
20
159
1.26
0.40
1.4
2.4
—
—
—
0
0
19
150
1.27
0.40
6.2
5.4
550.10
59.56
u/ml
—
5
50
0
18
0.00
0.40
0.0
1.0
—
76.44
—
0
18
5
35
1.43
0.39
2.8
1.7
—
—
—
0
0
466
4495
1.05
0.39
1.5
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
2.5
—
37.18
—
0
19
15
116
1.30
0.37
1.6
1.7
2220.33
1923.41
ml
0.56
15
111
29
343
0.84
0.36
1.1
1.5
108.49
215.03
pmol/l
1.16
29
337
36
309
1.17
0.36
1.3
1.1
6.96
1.88
u/ml
0.92
25
166
114
1053
1.09
0.36
1.2
1.3
—
—
—
0
0
22
180
1.23
0.36
1.4
1.4
14860.00
74680.35
e6/l
1.44
12
103
6
43
1.40
0.35
1.3
2.2
—
—
—
0
0
6
45
1.33
0.33
1.2
1.4
12.92
7.66
mmol/l
—
6
45
23
274
0.84
0.32
1.7
1.5
—
—
—
0
0
11
83
1.33
0.32
1.1
1.3
160.10
140.63
nmol/l
0.31
11
83
21
174
1.21
0.31
1.4
1.4
—
—
—
0
0
12
93
1.29
0.30
1.0
1.2
—
—
—
0
0
18
149
1.21
0.28
1.2
1.2
—
—
—
0
0
8
64
1.25
0.27
1.1
1.1
—
10.43
—
0
7
14
114
1.23
0.25
1.3
1.1
23.86
17.73
u/ml
—
5
50
12
96
1.25
0.24
2.0
1.7
81.33
101.29
ng/l
0.74
12
96
9
77
1.17
0.24
3.0
2.9
—
—
—
0
0
26
227
1.15
0.23
1.2
1.2
—
—
—
0
0
28
246
1.14
0.23
1.3
1.2
—
—
—
0
0
30
265
1.13
0.23
1.0
1.0
—
—
—
0
0
15
179
0.84
0.23
1.3
1.2
—
—
—
0
0
21
181
1.16
0.22
1.7
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
8
101
0.79
0.21
1.0
1.0
—
—
—
0
0
27
240
1.13
0.20
1.6
1.5
0.25
0.33
nmol/l
0.60
22
188
10
81
1.24
0.18
1.9
2.5
2134.00
1888.94
ml
—
10
71
19
217
0.87
0.18
1.2
1.2
—
—
—
0
0
36
328
1.10
0.18
5.7
3.6
29.22
26.22
mg/l
0.18
30
230
15
128
1.17
0.18
2.3
2.1
1.33
1.99
u/field
—
9
76
15
128
1.17
0.18
1.4
1.1
416.00
152.00
titre
—
5
20
12
100
1.20
0.18
1.4
1.4
160.28
157.32
pmol/l
0.03
12
100
38
348
1.09
0.18
3.1
3.5
0.73
0.79
nmol/l
0.51
26
286
20
176
1.14
0.17
1.5
1.6
—
—
—
0
0
77
728
1.06
0.17
1.6
1.4
26.42
27.60
iu/l
0.13
66
621
68
641
1.06
0.16
4.5
3.6
129.98
2195.62
u/ml
0.76
61
563
13
111
1.17
0.15
1.1
1.1
—
—
—
0
0
24
216
1.11
0.15
1.1
1.1
7.38
3.97
u/ml
0.51
13
97
139
1342
1.04
0.14
1.4
1.4
—
—
—
0
0
15
171
0.88
0.14
1.0
1.1
—
—
—
0
0
33
304
1.09
0.14
1.3
1.2
—
—
—
0
0
46
431
1.07
0.14
3.6
2.7
62.91
60.52
%
0.32
46
419
76
725
1.05
0.13
1.8
2.0
—
—
—
0
0
11
128
0.86
0.13
1.6
3.3
9.80
30.03
mg/l
—
6
97
73
765
0.95
0.13
1.6
1.7
—
—
—
0
0
23
209
1.10
0.13
1.4
1.4
953.07
1658.49
e6/l
0.88
15
143
78
746
1.05
0.13
1.1
1.1
—
—
—
0
0
11
95
1.16
0.11
2.5
1.6
—
—
—
0
0
21
227
0.92
0.09
1.9
1.9
—
—
—
0
0
6
57
1.05
0.08
2.5
1.8
—
—
—
0
0
5
62
0.81
0.08
1.8
2.3
101.40
140.27
nmol/l
—
5
55
5
65
0.77
0.08
2.0
1.7
39.58
40.20
g/l
—
5
65
7
66
1.06
0.08
1.9
2.8
—
—
—
0
0
16
147
1.09
0.07
1.2
1.3
—
—
—
0
0
28
265
1.06
0.07
1.5
1.7
—
—
—
0
0
12
132
0.91
0.06
1.0
1.1
—
—
—
0
0
17
183
0.93
0.06
1.2
1.3
6.54
7.48
mmol/l
0.92
12
158
16
171
0.94
0.05
3.6
2.5
—
—
—
0
0
13
120
1.08
0.05
1.1
1.1
—
—
—
0
0
50
514
0.97
0.04
1.1
1.1
0.58
0.66
ratio
—
7
68
17
180
0.94
0.04
1.6
1.2
—
—
—
0
0
33
319
1.04
0.03
1.6
1.3
63.68
60.63
mmol/l
0.21
28
253
26
270
0.96
0.03
2.9
4.1
25.64
26.02
u/ml
0.02
26
263
13
122
1.07
0.02
1.2
1.2
25.46
13.49
u/l
0.42
13
114
23
237
0.97
0.01
1.3
1.2
2.11
4.22
u/ml
—
9
108
61
603
1.01
0.01
1.6
1.6
884.79
979.66
mu/l
0.48
53
504
11
116
0.95
0.00
1.6
1.4
—
—
—
0
0
56
554
1.01
0.00
1.1
1.1
1.52
1.54
g/l
0.32
56
554
47
475
0.99
0.00
1.2
1.3
180.82
241.51
miu/ml
0.61
17
226
23
233
0.99
0.00
1.2
1.1
9.55
2.58
u/ml
1.17
14
121
5
52
0.96
0.00
1.6
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
52.12
—
0
9
0
9
0.00
0.00
0.0
1.3
—
0.16
—
0
9
8
84
0.95
0.00
2.9
1.8
0.88
4.79
u/field
—
8
64
6
59
1.02
-0.00
1.5
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
396.57
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
0.06
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
-0.00
1.1
1.7
—
—
—
0
0
20
200
1.00
-0.00
1.1
1.1
0.67
0.28
u/ml
—
6
69
6
65
0.92
-0.00
1.0
1.2
9.17
10.23
mm/h
—
6
65
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
89
0.90
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.8
—
99.17
—
0
6
6
67
0.90
-0.00
1.0
1.4
176.00
168.10
mmol/24h
—
6
67
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_HERPESKERATITIS and mortality.

Females

Parameter HR [95% CI] p-value
H7_HERPESKERATITIS 1.265 [1.13, 1.41] < 0.001
Birth year 0.996 [0.99, 1.0] 0.337

During the follow-up period (1.1.1998 — 31.12.2019), 1095 out of 6103 females with H7_HERPESKERATITIS died.

Males

Parameter HR [95% CI] p-value
H7_HERPESKERATITIS 1.22 [1.09, 1.37] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 1073 out of 5181 males with H7_HERPESKERATITIS died.

Mortality risk

Mortality risk for people of age

years, who have H7_HERPESKERATITIS.

N-year risk Females Males
1 0.162% 0.24%
5 0.728% 1.368%
10 1.919% 3.58%
15 3.975% 6.901%
20 6.792% 11.807%

Relationships between endpoints

Index endpoint: H7_HERPESKERATITIS – Herpesviral keratitis and keratoconjunctivitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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