Perioral dermatitis

L12_PERIORALDERM

rosacea: a chronic skin condition characterized by facial redness, small and superficial dilated blood vessels on facial skin, papules, pustules, and swelling.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L71.0#
  • Hospital discharge: ICD-9 6953B
  • Cause of death: ICD-10 L71.0#
  • Cause of death: ICD-9 6953B

2 out of 7 registries used, show all original rules.

1067

4. Check minimum number of events

None

1067

5. Include endpoints

None

1067

6. Filter based on genotype QC (FinnGen only)

959

Control definitions (FinnGen only)

Control exclude
L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L71
Name in latin
Dermatitis perioralis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4435 3704 720
Only index persons 4253 3606 647
Unadjusted period prevalence (%)
Whole population 0.09 0.11 0.02
Only index persons 0.12 0.13 0.02
Median age at first event (years)
Whole population 40.59 40.25 42.27
Only index persons 40.98 40.43 44.06

-FinnGen-

Key figures

All Female Male
Number of individuals 959 867 92
Unadjusted period prevalence (%) 0.28 0.31 0.04
Median age at first event (years) 46.33 45.57 53.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
990
Matched controls
9900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L71.0
ICD-10 Finland
Perioral dermatitis
4503599627370496.0
307.7
988
91
D06BX01
ATC
metronidazole; topical
24.5
307.7
613
617
J01AA04
ATC
lymecycline; systemic
10.4
305.5
498
876
L71.8
ICD-10 Finland
Other rosacea
51.0
173.9
101
22
J01AA07
ATC
tetracycline; systemic
5.5
144.7
392
1046
L71.9
ICD-10 Finland
Rosacea, unspecified
17.0
138.0
119
79
E0000UV, ,
ATC
3.7
85.3
640
3280
D10AX03
ATC
azelaic acid; topical
4.7
83.3
230
597
L71
ICD-10 Finland
Rosacea
8.9
68.1
88
107
L70.0
ICD-10 Finland
Acne vulgaris
8.3
66.4
91
119
D10BA01
ATC
isotretinoin; oral
4.7
63.7
167
411
XQ802
NOMESCO Finland
Epicutan test
5.0
47.3
108
235
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.3
46.3
133
348
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.8
45.8
326
1492
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.3
42.1
181
622
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.5
34.3
276
1315
XQ800
NOMESCO Finland
Prick test
3.2
32.0
141
488
E000001, ,
ATC
2.4
30.1
280
1413
D07AD01
ATC
clobetasol; topical
2.5
28.2
213
976
D07AC01
ATC
betamethasone; topical
2.1
27.9
407
2453
L70
ICD-10 Finland
Acne
5.2
27.8
59
120
D07AC13
ATC
mometasone; topical
2.2
27.5
345
1959
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
27.5
367
2135
L20.0
ICD-10 Finland
Besnier prurigo
2.8
27.0
157
631
L04AX03
ATC
methotrexate; systemic
2.9
26.8
142
543
J02AC01
ATC
fluconazole; systemic
2.0
26.1
541
3681
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.5
24.2
177
795
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
23.8
452
2950
D02AE01
ATC
carbamide; topical
3.3
23.1
92
298
D07XC01
ATC
betamethasone; topical
2.7
22.0
135
555
L04AX01
ATC
azathioprine; systemic
3.8
19.8
63
176
D07AB08
ATC
desonide; topical
2.4
19.3
143
642
H02AB06
ATC
prednisolone; systemic
1.8
19.1
481
3368
S01GX01
ATC
cromoglicic acid; ophthalmic
1.9
18.0
285
1716
XQ848
NOMESCO Finland
Dermatological photography
4.9
17.9
40
85
R06AX27
ATC
desloratadine; oral
1.8
17.6
389
2598
R06AE09
ATC
levocetirizine; oral
2.1
17.4
200
1074
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.0
16.3
74
258
D02AX
ATC
Other emollients and protectives
3.7
15.9
52
148
E0001A1, ,
ATC
4.3
15.7
41
99
D11AH01
ATC
tacrolimus; topical
5.9
15.0
27
47
R06AE07
ATC
cetirizine; oral
1.7
14.8
510
3810
L57.0
ICD-10 Finland
Actinic keratosis
2.6
14.5
85
340
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
4.2
14.3
38
93
L43.8
ICD-10 Finland
Other lichen planus
5.4
14.2
28
53
UJF32
NOMESCO Finland
Coloscopy
1.9
14.1
225
1344
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.9
14.1
66
235
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.2
14.0
123
592
J02AC02
ATC
itraconazole; systemic
1.9
13.9
194
1110
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
5.3
13.5
27
52
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
13.1
254
1605
P01BA02
ATC
hydroxychloroquine; oral
2.3
12.9
101
462
L30.8
ICD-10 Finland
Other specified dermatitis
3.5
12.9
44
129
L71.1
ICD-10 Finland
Rhinophyma
+∞
12.5
12
*
S29
ICPC
Skin symptom/complaint other
1.8
12.5
221
1358
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
5.7
12.5
23
41
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
4.6
12.2
29
65
R96
ICPC
Asthma
2.2
12.2
114
562
R01AD08
ATC
fluticasone; nasal
1.7
12.1
322
2217
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
12.0
148
808
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
5.1
12.0
25
50
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
11.9
257
1671
E000006, ,
ATC
2.4
11.7
82
357
TQW80
NOMESCO Finland
Local dermatologic skincare
4.3
11.6
30
72
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.1
11.5
48
160
L04AA06
ATC
mycophenolic acid; systemic
4.9
11.5
25
52
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.9
11.3
147
817
D10AF01
ATC
clindamycin; topical
2.5
11.2
70
289
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
4.8
11.2
25
53
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.1
11.2
47
157
L04AD01
ATC
ciclosporin; systemic
4.5
10.8
26
59
S01AD03
ATC
aciclovir; ophthalmic
3.2
10.7
43
140
ZXC50
NOMESCO Finland
Cryotherapy
4.2
10.7
28
68
L70.1
ICD-10 Finland
Acne conglobata
60.7
10.6
12
*
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.6
10.6
492
3839
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
5.1
10.6
22
44
L50.3
ICD-10 Finland
Dermatographic urticaria
3.9
10.5
31
82
D07AA02
ATC
hydrocortisone; topical
1.8
10.4
164
969
L21
ICD-10 Finland
Seborrhoeic dermatitis
4.0
10.2
29
75
L01BA01
ATC
methotrexate; systemic
3.1
10.1
42
140
J01AA02
ATC
doxycycline; systemic
1.6
9.9
727
6246
B07.9
ICD-10 Finland
Verruca simplex
2.8
9.9
50
186
L70.9
ICD-10 Finland
Acne, unspecified
8.2
9.9
21
26
R06AX22
ATC
ebastine; oral
1.7
9.8
198
1255
L21.9
ICD-10 Finland
Seborrhoeic dermatitis, unspecified
4.4
9.8
24
55
WYA00, ,
SPAT
3.9
9.7
28
73
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.3
9.6
77
356
R01AD58
ATC
fluticasone, combinations; nasal
1.6
9.5
311
2227
D11AH02
ATC
pimecrolimus; topical
9.6
9.3
18
19
L20
ICD-10 Finland
Atopic dermatitis
2.6
9.2
54
217
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
9.1
288
2043
A02BC02
ATC
pantoprazole; systemic
1.5
9.1
622
5204
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
7.1
9.1
21
30
SPAT1153
SPAT
Removal of sutures
1.6
9.1
258
1785
L30.3
ICD-10 Finland
Infective dermatitis
2.9
8.9
42
150
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.4
8.9
62
270
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.1
8.8
81
397
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
2.1
8.7
81
398
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
2.6
8.7
51
205
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
4.7
8.4
19
41
J01DB01
ATC
cefalexin; oral
1.7
8.3
817
7324
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
2.5
8.2
51
211
L04AB04
ATC
adalimumab; parenteral
3.0
8.1
35
119
R01AD12
ATC
fluticasone furoate; nasal
1.5
8.1
370
2827
A02BC05
ATC
esomeprazole; systemic
1.5
8.1
366
2793
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.2
8.0
64
296
S18
ICPC
Laceration/cut
1.5
8.0
413
3232
J01FA10
ATC
azithromycin; systemic
1.5
7.9
627
5327
D09AB01
ATC
zinc bandage without supplements; topical
4.5
7.9
19
43
R69
ICD-10 Finland
Unknown and unspecified causes of morbidity
4.0
7.9
22
56
D01AE16
ATC
amorolfine; topical
1.9
7.9
94
506
K51.5
ICD-10 Finland
Left sided colitis
3.1
7.8
32
106
D07XB05
ATC
dexamethasone; topical
3.0
7.7
33
112
D05AX52
ATC
calcipotriol, combinations; topical
2.5
7.7
49
205
H02AB07
ATC
prednisone; oral
1.8
7.7
120
705
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.1
7.6
70
343
L21.0
ICD-10 Finland
Seborrhoea capitis
6.8
7.6
18
27
L73.8
ICD-10 Finland
Other specified follicular disorders
12.0
7.6
13
11
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.8
7.6
38
141
A07EC01
ATC
sulfasalazine; oral, rectal
2.0
7.6
79
406
C10AC01
ATC
colestyramine; oral
3.0
7.6
32
108
G03HB01
ATC
cyproterone and estrogen; oral
1.7
7.5
144
897
H01.0
ICD-10 Finland
Blepharitis
1.9
7.5
90
487
A07EC02
ATC
mesalazine; oral, rectal
2.3
7.4
55
247
H02AB04
ATC
methylprednisolone; systemic
1.7
7.3
131
800
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
7.3
605
5145
N05CF02
ATC
zolpidem; oral
1.6
7.3
173
1139
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.9
7.1
95
531
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.8
7.1
99
561
R01AD09
ATC
mometasone; nasal
1.4
7.1
484
3963
E000007, ,
ATC
2.1
7.1
66
325
UDC00
NOMESCO Finland
Ear microscopy
2.0
7.1
72
367
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
7.0
116
692
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
7.0
304
2285
L43.9
ICD-10 Finland
Lichen planus, unspecified
3.5
7.0
23
66
R01AD11
ATC
triamcinolone; nasal
1.9
7.0
90
498
S21
ICPC
Skin texture symptom/complaint
1.7
7.0
147
939
L50.9
ICD-10 Finland
Urticaria, unspecified
2.3
6.9
52
235
L82
ICD-10 Finland
Seborrhoeic keratosis
1.6
6.8
160
1050
L40
ICD-10 Finland
Psoriasis
3.1
6.8
27
88
D06BB03
ATC
aciclovir; topical
2.2
6.7
53
244
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
3.9
6.7
19
49
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.7
300
2266
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.9
6.7
78
417
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.8
6.7
96
550
N77.1*B37.3
ICD-10 Finland
Candidiasis of vulva and vagina
2.5
6.7
40
163
L43
ICD-10 Finland
Lichen planus
5.5
6.6
18
33
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
6.6
384
3043
J45.1
ICD-10 Finland
Nonallergic asthma
2.0
6.6
70
362
SPAT1263
SPAT
Sampling
1.4
6.6
399
3186
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.7
6.5
124
771
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
6.5
201
1406
L04AA01
ATC
[U] ciclosporin
5.4
6.5
18
34
E000002, ,
ATC
1.7
6.4
122
757
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
2.8
6.4
31
113
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
1.8
6.4
100
587
S99
ICPC
Skin disease other
3.1
6.3
25
81
WZA10
NOMESCO Finland
Extensive medical or dental certificate
3.6
6.3
20
56
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
6.3
353
2773
TQW99
NOMESCO Finland
Other minor procedure on skin
2.4
6.3
41
174
D07CC01
ATC
betamethasone and antibiotics; topical
1.7
6.3
122
762
R53
ICD-10 Finland
Malaise and fatigue
1.5
6.3
256
1896
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.1
6.2
58
286
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.4
6.2
42
181
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.3
6.2
47
213
S01XA18
ATC
ciclosporin; ophthalmic
6.3
6.2
15
24
R03BA02
ATC
budesonide; inhalant
1.5
6.2
186
1293
D07BA04
ATC
hydrocortisone and antiseptics; topical
1.7
6.2
105
633
M03BX02
ATC
tizanidine; oral
1.4
6.1
607
5252
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
6.1
176
1213

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
641
4560
2.15
28.34
9.0
5.8
0.51
0.53
e9/l
2.00
582
3989
640
4571
2.13
27.72
9.0
5.9
0.04
0.04
e9/l
0.02
582
3996
645
4675
2.09
26.12
9.1
5.8
1.85
1.96
e9/l
2.09
600
4183
650
4735
2.09
25.83
9.4
6.1
0.17
0.18
e9/l
1.15
604
4191
599
4258
2.03
25.18
8.6
5.8
55.99
56.48
%
0.49
575
4070
591
4191
2.02
24.89
9.0
6.0
8.52
8.32
%
0.93
562
3941
590
4190
2.01
24.64
8.9
5.9
2.80
2.72
%
0.33
561
3926
589
4185
2.01
24.51
9.0
6.0
0.74
0.68
%
1.96
559
3916
602
4316
2.01
24.34
8.8
5.9
29.86
29.41
%
0.49
575
4107
362
2293
1.91
19.96
6.0
4.2
—
—
—
0
0
662
5097
1.90
19.50
11.4
8.7
3.73
3.94
e9/l
1.28
605
4475
242
1395
1.97
17.27
1.7
1.4
650.83
560.40
titre
0.22
48
302
408
2826
1.75
15.91
9.3
6.0
—
—
—
0
0
86
335
2.72
15.50
1.3
1.2
—
—
—
0
0
177
949
2.05
15.32
1.9
1.5
—
—
—
0
0
762
6400
1.83
14.06
9.7
7.2
73.47
75.00
u/l
0.57
728
6074
181
1021
1.95
13.45
1.5
1.4
—
—
—
0
0
141
730
2.09
13.31
1.7
1.3
195.51
312.24
u/ml
0.44
131
680
92
403
2.41
13.00
1.4
1.3
0.97
0.60
u/ml
—
9
24
538
4169
1.64
12.78
3.0
2.5
81.31
75.94
nmol/l
4.45
504
3867
92
414
2.35
12.24
2.6
2.0
9.34
8.54
iu/ml
0.10
25
88
480
3648
1.61
12.10
2.3
2.0
—
—
—
0
0
731
6175
1.70
11.92
5.3
4.3
—
2.94
—
0
7
276
1858
1.67
11.11
1.4
1.3
9.04
9.99
u/ml
0.10
125
746
69
289
2.49
10.74
1.4
1.3
2.55
2.89
u/ml
—
6
23
69
290
2.48
10.67
1.4
1.3
18.63
13.00
u/ml
0.14
13
42
314
2244
1.58
9.71
1.8
1.5
2.28
2.14
g/l
0.78
219
1420
489
3857
1.53
9.69
8.7
6.2
1.22
1.22
mmol/l
0.25
421
3322
219
1437
1.67
9.55
3.3
2.4
111.31
98.45
ug/g
0.27
175
1129
617
5135
1.53
9.38
3.8
3.2
84.16
74.74
ug/l
0.96
578
4868
938
8724
2.43
9.34
17.3
12.4
17.04
20.11
mg/l
3.17
763
7011
502
4010
1.51
9.19
15.1
9.7
0.01
0.00
e9/l
0.71
431
3300
200
1306
1.67
8.82
2.7
2.3
14.14
13.99
umol/l
0.11
182
1215
121
686
1.87
8.70
5.3
2.9
10.53
10.28
g/l
0.30
113
636
282
2012
1.56
8.61
1.4
1.3
19.82
27.20
iu/ml
1.13
93
595
349
2622
1.51
8.36
1.5
1.3
1.10
1.63
u/ml
0.70
104
716
431
3392
1.48
8.16
5.9
4.4
36.96
36.70
g/l
0.49
400
3207
313
2309
1.52
8.13
4.2
3.5
7.40
7.40
ph
0.05
223
1629
150
926
1.73
8.11
1.4
1.3
—
—
—
0
0
78
393
2.07
7.88
1.6
1.3
—
—
—
0
0
125
741
1.79
7.77
6.6
4.2
1.00
1.03
%
0.03
34
185
146
906
1.72
7.74
2.6
2.1
339.77
389.18
nmol/l
2.20
133
853
121
712
1.80
7.71
6.8
4.3
0.10
0.09
%
0.04
30
156
166
1069
1.66
7.66
2.8
2.3
23.23
23.12
%
0.04
155
994
173
1128
1.65
7.60
3.2
3.0
4.02
4.61
e9/l
0.69
158
1005
180
1190
1.63
7.48
2.7
2.2
2.42
2.42
g/l
0.04
160
1098
33
115
2.93
7.38
1.5
1.3
—
—
—
0
0
517
4270
1.44
7.33
6.2
5.7
9.88
10.25
umol/l
0.56
482
4054
581
4906
1.45
7.29
4.7
3.6
0.00
5.88
estimate
1.34
144
1021
362
2817
1.45
6.97
3.7
2.9
0.09
0.08
estimate
0.04
127
838
574
4859
1.43
6.95
4.7
3.6
0.00
0.00
estimate
0.50
145
1005
121
734
1.74
6.94
7.2
4.5
0.32
0.15
%
0.21
28
150
58
274
2.19
6.93
1.5
1.2
—
—
—
0
0
117
704
1.75
6.90
6.6
4.1
0.61
0.71
%
0.17
31
178
425
3421
1.42
6.75
8.0
5.7
1.22
1.22
mmol/l
0.74
397
3158
581
4944
1.42
6.74
4.7
3.6
0.01
0.01
estimate
0.14
143
980
54
251
2.22
6.72
1.4
1.2
21.66
45.88
u/ml
—
7
26
905
8446
1.83
6.72
6.7
5.7
1.69
1.79
mu/l
2.58
857
8014
821
7476
1.58
6.66
5.5
4.8
14.39
14.45
pmol/l
0.31
765
7003
455
3719
1.41
6.57
4.5
3.4
0.03
0.03
estimate
0.03
124
828
39
160
2.50
6.42
4.6
4.0
3.58
4.15
e9/l
1.04
39
160
89
508
1.83
6.27
2.9
3.1
63.06
72.05
e9/l
1.43
68
362
93
540
1.80
6.20
2.6
1.8
1.27
1.29
g/l
0.04
86
501
135
875
1.63
6.03
1.5
1.4
—
—
—
0
0
172
1183
1.55
5.97
1.2
1.2
—
—
—
0
0
426
3496
1.38
5.77
2.1
1.9
95.10
97.93
pmol/l
0.83
215
1849
137
902
1.60
5.74
9.3
5.0
1.06
1.05
mmol/l
0.25
124
832
324
2544
1.41
5.69
4.4
3.0
15.55
76.49
e6/l
1.43
255
1899
49
236
2.13
5.62
12.8
4.1
1.48
1.28
mg/l
0.89
49
209
952
9105
2.19
5.52
15.3
10.4
24.02
23.97
u/l
0.03
940
8870
18
52
3.51
5.47
3.8
3.2
12.77
11.14
index
0.48
13
29
293
2274
1.41
5.47
2.7
2.1
2.69
2.64
mg/l
0.14
250
1970
188
1343
1.49
5.44
1.7
1.5
—
—
—
0
0
42
194
2.22
5.35
2.9
2.7
1.35
1.89
index
0.38
20
91
42
194
2.22
5.35
1.9
1.3
224.50
223.27
u/ml
0.01
26
124
17
48
3.59
5.34
4.5
2.9
880.41
629.54
u/ml
0.42
17
48
283
2192
1.41
5.32
4.2
2.9
0.13
0.34
e6/l
3.36
213
1555
327
2597
1.39
5.30
2.9
2.4
58.48
61.81
u/l
0.40
302
2407
330
2625
1.39
5.30
5.1
3.7
0.00
0.00
estimate
1.08
144
973
230
1723
1.44
5.20
3.8
2.5
5.16
8.30
e6/l
3.75
211
1571
981
9587
3.56
5.11
26.6
19.3
6.41
6.64
e9/l
2.96
971
9413
981
9585
3.58
5.11
26.5
19.3
4.45
4.47
e12/l
0.83
972
9418
981
9584
3.59
5.11
27.4
19.5
44.61
40.01
%
0.49
976
9502
981
9584
3.59
5.11
26.4
19.2
30.23
30.08
pg
1.88
976
9506
981
9583
3.61
5.10
26.5
19.2
90.68
90.41
fl
1.12
976
9506
25
93
2.73
5.03
2.0
1.3
—
—
—
0
0
21
71
3.00
5.01
1.0
1.1
113.48
111.35
pmol/l
0.09
21
71
110
710
1.62
5.00
2.9
3.0
1.61
1.77
%
1.01
97
639
981
9590
3.52
4.97
26.7
19.4
133.45
133.54
g/l
0.08
976
9510
25
94
2.70
4.94
1.5
1.3
3.43
2.97
g/l
0.55
19
69
25
94
2.70
4.94
1.5
1.3
0.47
0.37
g/l
0.55
19
71
217
1626
1.43
4.87
1.7
1.7
429.60
42694658.71
pmol/l
2.53
187
1403
254
1965
1.39
4.74
3.1
2.4
311.74
309.53
umol/l
0.14
228
1755
22
79
2.83
4.74
1.1
1.1
—
—
—
0
0
381
3148
1.34
4.67
5.2
3.6
19.36
67.15
e6/l
5.84
272
2059
337
2741
1.35
4.57
2.2
2.1
—
—
—
0
0
850
7952
1.49
4.53
4.3
3.8
1.13
1.21
mmol/l
4.30
797
7460
24
94
2.59
4.41
1.5
1.3
—
—
—
0
0
24
94
2.59
4.41
1.5
1.3
6.42
6.17
g/l
0.17
18
71
16
50
3.24
4.35
1.4
1.6
48.43
39.22
%
—
7
27
36
171
2.15
4.33
1.8
1.5
—
—
—
0
0
458
3925
1.31
4.22
4.1
3.2
6.21
6.24
ph
0.22
255
2238
420
3567
1.31
4.10
2.0
1.9
1.22
1.33
mmol/l
2.53
365
3110
38
189
2.05
4.08
1.4
1.5
—
—
—
0
0
113
771
1.53
4.06
5.5
3.5
—
—
—
0
0
83
527
1.63
4.05
2.2
2.7
66.86
67.23
g/l
0.14
78
492
947
9126
1.87
4.01
20.9
15.0
70.96
68.24
umol/l
2.48
939
9018
41
214
1.96
3.87
5.1
3.6
53.44
58.30
%
1.44
41
214
41
214
1.96
3.87
1.4
1.5
426.69
113.55
e6/l
0.58
32
164
33
159
2.11
3.86
1.8
1.4
110.93
154.64
au/ml
1.33
12
43
349
2909
1.31
3.85
2.9
3.2
2.34
2.35
mmol/l
1.54
314
2686
980
9579
3.28
3.85
26.6
19.3
263.28
263.30
e9/l
0.00
973
9430
264
2116
1.34
3.84
4.1
2.8
—
0.00
estimate
—
0
5
9
15
6.04
3.82
3.2
2.8
—
—
—
0
0
900
8575
1.55
3.81
17.8
13.4
3.91
3.91
mmol/l
0.18
881
8358
88
577
1.58
3.78
2.7
2.5
0.16
0.39
e6/l
1.08
81
546
84
547
1.59
3.72
1.3
1.2
—
—
—
0
0
25
109
2.33
3.71
1.3
1.2
0.67
16.91
nmol/l
0.49
20
104
653
5924
1.30
3.70
5.3
4.3
4188.14
1488.00
e6/l
—
7
76
17
61
2.82
3.70
2.9
1.9
42.22
44.52
%
0.29
17
61
274
2219
1.32
3.70
1.7
1.6
20.91
20.83
nmol/l
0.04
235
1923
373
3151
1.29
3.69
11.8
9.6
1.12
1.13
inr
0.25
316
2591
263
2119
1.33
3.68
2.0
1.8
0.72
0.97
mg/l
2.08
197
1602
898
8562
1.53
3.67
17.5
13.3
139.56
139.65
mmol/l
0.58
883
8373
279
2275
1.32
3.57
2.6
2.1
125.10
171.38
u/l
0.87
267
2167
102
701
1.51
3.56
3.2
3.5
4.36
4.57
pmol/l
1.75
94
626
91
614
1.53
3.46
3.5
3.0
1.23
1.23
mmol/l
0.11
80
522
121
871
1.44
3.35
1.1
1.2
—
—
—
0
0
39
211
1.88
3.35
1.3
1.4
6.19
7.62
e6/l
0.12
27
156
225
1796
1.33
3.33
4.5
3.9
—
—
—
0
0
11
28
3.96
3.29
1.2
1.4
—
6.63
%
—
0
8
31
156
2.02
3.27
1.5
1.6
0.51
0.65
g/l
0.54
23
127
44
250
1.80
3.25
1.7
2.4
1.30
1.37
g/l
0.28
39
223
8
15
5.37
3.19
1.1
1.3
—
—
—
0
0
19
79
2.43
3.15
1.3
1.8
49.56
51.49
%
—
9
47
189
1485
1.34
3.10
3.9
2.5
493.95
507.64
mosm/kgh2o
0.40
171
1317
57
354
1.65
3.09
2.4
2.2
—
—
—
0
0
21
93
2.29
3.05
1.3
1.2
0.16
0.38
nmol/l
0.49
11
65
891
8531
1.44
3.04
5.4
5.0
2.78
2.81
mmol/l
0.71
847
8077
64
412
1.59
3.01
1.7
2.1
0.09
0.01
estimate
0.43
22
136
127
941
1.40
3.01
3.6
2.7
5.67
5.88
umol/l
0.08
112
804
26
127
2.08
2.99
1.1
1.6
—
—
—
0
0
44
257
1.75
2.99
1.2
1.2
—
—
—
0
0
138
1041
1.38
2.94
2.4
1.9
—
—
—
0
0
21
95
2.24
2.91
1.4
1.2
—
—
nmol/l
—
0
0
157
1212
1.35
2.90
3.4
2.8
3.46
4.22
e6/l
0.30
77
543
146
1115
1.36
2.88
1.3
1.2
—
—
—
0
0
883
8454
1.41
2.88
5.1
4.5
4.76
4.78
mmol/l
0.39
847
8023
66
433
1.56
2.88
2.0
2.2
—
—
—
0
0
145
1110
1.36
2.82
1.7
1.7
1212.03
1196.63
nmol/l
0.06
107
844
110
806
1.41
2.79
2.7
2.2
12622.37
6713.87
u/l
0.82
42
366
53
334
1.62
2.74
1.2
1.3
13.09
10.62
u/l
0.39
37
272
68
455
1.53
2.73
1.0
1.1
—
—
—
0
0
95
682
1.43
2.70
3.1
2.4
0.23
0.22
g/l
0.69
89
645
121
909
1.38
2.65
1.3
1.2
77.61
151.34
u/ml
2.51
48
368
879
8431
1.38
2.63
4.8
4.4
1.61
1.54
mmol/l
4.37
831
7966
215
1758
1.28
2.63
2.9
2.8
836.56
789.12
ng/l
0.10
176
1455
26
134
1.97
2.62
4.2
2.6
2.81
2.48
mmol/l
0.19
16
83
40
237
1.72
2.61
1.3
1.4
424.20
471.76
mg/l
0.32
40
224
21
100
2.12
2.60
1.5
1.4
—
—
—
0
0
30
163
1.87
2.60
1.5
3.4
1.14
4.54
ratio
0.83
17
90
9
25
3.62
2.58
2.1
1.6
—
—
—
0
0
155
1219
1.32
2.53
5.7
3.4
0.82
0.82
mmol/l
0.13
148
1159
83
589
1.45
2.52
5.6
3.4
85.93
72.54
ng/l
0.71
75
526
851
8133
1.33
2.52
4.7
4.3
5.53
5.69
mmol/l
4.31
792
7612
28
151
1.88
2.49
3.5
2.2
5.39
6.96
pmol/l
1.40
28
151
112
841
1.37
2.47
1.3
1.4
25.49
25.72
iu/l
0.03
92
725
676
6298
1.23
2.40
3.6
3.0
32.19
36.82
u/l
1.41
638
6026
9
27
3.35
2.39
1.1
1.3
—
—
—
0
0
32
183
1.77
2.38
1.7
3.6
29.22
52.79
mg/l
0.61
25
153
32
183
1.77
2.38
1.7
3.6
27.68
69.27
mg/l
0.69
25
155
94
695
1.39
2.29
4.7
3.3
7.38
7.34
ph
4.16
67
496
164
1318
1.29
2.29
3.5
2.7
1.02
0.98
e6/l
0.02
88
648
19
93
2.06
2.22
1.7
1.6
—
—
—
0
0
46
298
1.57
2.17
1.1
1.1
1.23
7.31
eliau/ml
—
9
48
23
122
1.91
2.17
1.1
1.1
—
—
—
0
0
16
74
2.18
2.15
1.3
1.2
0.54
0.65
ratio
—
6
39
6
14
4.31
2.15
1.0
1.2
—
—
—
0
0
937
9130
1.49
2.14
14.3
11.1
—
—
—
0
0
28
160
1.77
2.11
1.0
1.1
—
—
—
0
0
136
1078
1.30
2.11
2.6
2.1
29.01
29.22
s
0.18
130
1046
287
2488
1.22
2.05
2.9
2.9
—
0.83
—
0
6
6
15
4.02
2.04
1.0
1.9
—
—
—
0
0
6
15
4.02
2.04
1.0
1.0
—
—
—
0
0
189
1574
1.25
1.97
1.7
1.5
—
—
—
0
0
168
1382
1.26
1.95
3.9
3.2
93.50
242.02
ng/l
1.26
102
852
18
92
1.97
1.91
1.0
1.2
35.62
33.52
mg/l
0.15
13
71
103
798
1.32
1.90
2.6
2.3
44.26
37.66
u/l
0.22
88
656
265
2297
1.21
1.88
1.9
1.8
—
—
—
0
0
43
285
1.53
1.87
1.3
1.4
3.15
3.00
ug/l
0.13
38
264
32
501
0.63
1.86
1.7
1.5
—
—
—
0
0
87
660
1.35
1.85
2.6
2.4
8.25
20.76
au/ml
—
10
80
90
687
1.34
1.84
1.3
1.2
—
—
—
0
0
517
4763
1.18
1.83
6.1
4.6
6.15
6.37
mmol/l
2.01
486
4388
106
830
1.31
1.82
1.7
2.0
0.04
0.03
estimate
0.09
26
176
7
23
3.06
1.80
2.4
2.1
67.73
49.30
ug/l
—
7
23
420
3807
1.18
1.80
2.8
2.7
—
—
—
0
0
39
258
1.53
1.73
5.7
3.5
606.23
338.56
mg/l
0.53
22
97
32
491
0.64
1.72
1.6
1.5
1.19
1.28
mm
0.66
24
362
69
513
1.37
1.68
1.4
1.3
195.92
233.03
miu/ml
0.47
39
266
73
548
1.36
1.68
1.2
1.1
—
1.08
—
0
5
309
2743
1.18
1.67
3.6
3.0
21.15
29.02
ng/l
1.02
162
1534
34
511
0.65
1.67
1.7
1.6
—
—
—
0
0
796
7643
1.21
1.62
21.7
15.3
13.42
13.40
%
0.20
784
7545
339
3047
1.17
1.57
4.0
3.0
29.96
28.14
u/l
0.72
317
2893
27
169
1.61
1.53
9.5
3.0
9.01
8.43
kpa
0.87
27
164
37
250
1.50
1.52
3.0
2.5
3.75
5.30
umol/l
0.84
26
189
7
27
2.60
1.51
2.6
2.0
41.00
26.07
%
—
7
27
6
21
2.87
1.50
2.2
3.4
0.62
0.62
mmol/l
—
6
21
41
284
1.46
1.50
1.2
1.4
0.35
0.48
nmol/l
0.70
31
233
26
163
1.61
1.47
1.0
1.1
—
—
—
0
0
54
396
1.38
1.46
3.2
2.8
90.87
137.61
ng/l
1.09
46
363
15
80
1.89
1.45
2.3
2.7
1.15
0.89
%
—
8
48
27
172
1.59
1.44
1.1
1.2
—
—
—
0
0
23
141
1.65
1.42
2.3
2.7
—
15.81
—
0
8
18
103
1.76
1.41
1.7
1.4
111.51
48.13
mu/l
0.32
18
96
54
399
1.37
1.40
1.6
1.5
0.32
0.28
mg/l
0.19
28
151
86
681
1.29
1.40
1.6
1.4
—
—
—
0
0
7
29
2.42
1.39
1.3
1.0
—
—
—
0
0
7
29
2.42
1.39
1.3
1.0
—
—
—
0
0
7
29
2.42
1.39
1.3
1.0
—
—
—
0
0
35
239
1.48
1.38
1.5
1.2
84.00
113.03
titre
—
5
33
5
121
0.41
1.38
4.8
6.4
315.80
376.29
umol/l
—
5
110
16
89
1.81
1.37
1.4
1.1
—
—
—
0
0
6
23
2.62
1.37
1.0
1.1
0.58
0.02
u/ml
—
6
23
5
17
2.95
1.36
1.0
1.1
—
—
—
0
0
70
542
1.31
1.35
4.9
3.2
—
—
—
0
0
21
128
1.65
1.34
1.1
1.4
—
—
—
0
0
16
90
1.79
1.33
3.5
3.5
14.24
22.46
mu/l
1.47
16
85
6
24
2.51
1.30
1.0
1.0
—
—
—
0
0
6
25
2.41
1.24
2.7
2.0
4.00
7.40
%
—
6
25
21
131
1.62
1.24
5.0
2.3
—
—
—
0
0
15
85
1.78
1.23
2.3
2.5
33.07
32.38
pg
0.25
15
85
293
2648
1.15
1.23
8.4
5.6
—
—
—
0
0
26
172
1.53
1.21
1.3
1.2
—
—
—
0
0
38
272
1.41
1.21
1.4
1.3
—
—
—
0
0
6
26
2.32
1.19
1.2
1.1
—
35.67
—
0
6
12
64
1.89
1.18
1.1
1.1
—
—
—
0
0
0
33
0.00
1.16
0.0
1.2
—
—
—
0
0
15
87
1.74
1.15
1.1
1.2
—
—
—
0
0
593
5630
1.13
1.15
3.8
3.4
—
0.33
—
0
9
19
119
1.61
1.12
2.2
2.2
—
—
—
0
0
52
398
1.32
1.12
1.8
1.9
—
—
—
0
0
17
104
1.65
1.10
1.9
1.6
24.56
26.36
ng/l
0.13
17
104
5
21
2.39
1.09
1.0
1.0
—
—
—
0
0
5
21
2.39
1.09
1.0
1.0
—
—
—
0
0
5
21
2.39
1.09
1.0
1.0
—
—
—
0
0
8
41
1.96
1.09
1.1
1.4
187.13
152.16
mmol/24h
—
8
41
10
52
1.93
1.06
1.0
1.1
1215.40
1507.87
miu/ml
—
10
52
53
411
1.31
1.05
7.2
3.3
7.42
7.42
ph
0.02
45
340
25
170
1.48
1.05
1.3
1.2
3.90
3.29
u/ml
—
10
65
14
82
1.72
1.05
1.4
1.1
—
—
—
0
0
52
403
1.31
1.04
1.6
1.6
10.70
10.52
u/ml
0.01
11
104
45
343
1.33
1.01
2.9
2.1
20.47
20.53
s
0.04
36
300
5
107
0.46
1.01
1.0
1.1
—
—
—
0
0
25
172
1.47
1.00
1.5
1.5
271.40
362.00
mu/l
2.06
20
139
20
131
1.54
1.00
1.9
1.5
—
—
—
0
0
803
7811
1.15
0.95
5.6
5.2
36.92
37.80
mmol/mol
2.88
768
7410
18
117
1.55
0.94
1.8
2.1
—
—
—
0
0
6
27
2.23
0.93
1.2
1.2
—
—
—
0
0
9
52
1.74
0.92
1.4
2.1
1495.11
1029.02
mg
—
9
52
9
52
1.74
0.92
4.0
2.8
—
—
—
0
0
55
442
1.26
0.86
2.3
2.2
3.77
5.86
ug/l
1.16
47
392
12
73
1.65
0.82
1.3
2.8
1.19
1.31
g/24h
—
5
50
173
1554
1.14
0.80
2.7
2.5
2.42
2.43
mmol/l
1.05
151
1407
28
207
1.36
0.80
1.1
1.1
27.48
15.04
au/ml
—
5
61
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
100
866
1.17
0.77
12.3
6.5
104.38
104.50
mmol/l
0.10
100
866
6
34
1.77
0.76
1.3
1.2
—
—
—
0
0
9
54
1.67
0.74
1.1
1.2
—
—
—
0
0
234
2153
1.11
0.74
4.7
3.6
1.02
1.73
kg/l
0.50
156
1418
35
272
1.30
0.73
2.1
1.8
—
—
—
0
0
5
25
2.00
0.72
1.6
1.8
21.52
106.21
u/l
—
5
25
11
68
1.62
0.72
1.4
1.6
0.55
0.47
e9/l
0.67
11
68
7
40
1.76
0.71
1.1
1.3
—
—
—
0
0
5
26
1.93
0.70
1.2
1.3
—
—
—
0
0
9
58
1.56
0.70
1.3
1.9
—
—
—
0
0
69
585
1.19
0.69
1.4
1.6
272.19
298.13
mu/l
0.35
63
521
63
531
1.20
0.67
4.9
4.7
1.32
2.39
ug/l
1.06
53
469
24
179
1.35
0.67
2.2
1.7
5364.26
9933.51
e6/l
0.68
19
133
7
43
1.63
0.67
1.1
1.1
165.13
178.38
iu/ml
—
7
43
291
2724
1.10
0.65
3.3
2.7
—
—
—
0
0
55
655
0.83
0.65
1.5
1.5
66.86
60.92
ug/l
0.35
46
559
11
70
1.58
0.65
1.5
1.4
—
—
—
0
0
5
29
1.73
0.64
1.0
1.1
27.60
28.28
s
—
5
29
11
165
0.66
0.63
2.9
4.4
3.83
3.84
mmol/l
0.03
11
165
11
71
1.56
0.62
1.5
1.5
13.44
9.66
umol/l
0.93
11
63
5
30
1.67
0.61
1.4
1.2
—
—
—
0
0
15
105
1.44
0.60
1.7
1.4
—
—
—
0
0
15
105
1.44
0.60
1.7
1.4
—
—
—
0
0
15
105
1.44
0.60
1.7
1.4
—
—
—
0
0
15
105
1.44
0.60
1.7
1.4
—
—
—
0
0
447
4278
1.08
0.59
2.9
2.7
—
—
estimate
—
0
0
8
53
1.51
0.58
1.1
1.0
11.90
12.03
u/ml
—
8
39
64
552
1.17
0.55
16.9
8.4
—
—
—
0
0
19
142
1.34
0.54
1.2
1.2
—
—
—
0
0
17
125
1.37
0.54
5.4
2.8
35.82
32.45
umol/l
0.42
17
112
32
259
1.24
0.53
1.2
1.1
1.30
1.88
u/ml
0.43
21
127
40
332
1.21
0.53
11.3
2.6
0.67
0.63
%
0.39
40
332
301
2850
1.08
0.52
2.5
2.1
—
—
—
0
0
19
144
1.33
0.51
3.6
3.5
—
—
—
0
0
39
328
1.20
0.47
2.6
2.8
0.41
0.75
ug/l
3.97
20
195
20
253
0.79
0.45
8.6
7.7
—
—
—
0
0
23
184
1.26
0.43
1.1
1.1
—
—
—
0
0
8
56
1.43
0.42
1.4
1.1
—
—
—
0
0
13
96
1.36
0.41
1.2
1.2
13.24
15.06
u/ml
—
5
46
221
2088
1.08
0.41
5.3
3.6
96.39
95.82
%
0.14
215
2035
5
33
1.52
0.41
1.4
3.6
7.44
8.35
mmol/l
—
5
33
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
8
59
1.36
0.41
1.0
1.2
4.75
7.32
mm/h
—
8
59
5
34
1.47
0.40
1.4
1.4
151.60
72.65
nmol/24h
—
5
34
8
61
1.31
0.39
2.5
1.5
—
—
—
0
0
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
24
197
1.22
0.38
1.1
1.0
0.08
0.09
u/ml
0.02
11
58
28
234
1.20
0.37
1.0
1.1
—
—
—
0
0
28
234
1.20
0.37
1.0
1.1
—
—
—
0
0
45
394
1.15
0.36
9.8
3.1
133.00
128.80
g/l
0.98
45
381
30
254
1.19
0.36
1.3
1.4
355.20
303.29
ug/g
0.72
15
147
14
108
1.30
0.35
1.4
1.4
40.23
34.89
nmol/l
0.37
14
97
52
462
1.13
0.34
1.2
1.2
0.83
0.88
g/l
0.68
52
462
293
3049
0.94
0.34
1.7
1.7
—
—
—
0
0
21
254
0.82
0.34
1.3
1.9
—
—
—
0
0
11
82
1.35
0.34
3.7
2.6
—
—
—
0
0
11
82
1.35
0.34
1.1
1.1
—
—
—
0
0
12
91
1.32
0.34
1.5
1.3
0.66
1.75
u/ml
—
7
41
6
45
1.34
0.33
3.0
3.4
—
—
—
0
0
84
770
1.10
0.33
2.5
2.1
6.20
6.18
ph
0.06
45
499
225
2147
1.06
0.32
2.6
2.1
—
—
—
0
0
27
229
1.18
0.32
1.2
1.0
6.56
5.80
u/ml
0.09
16
114
106
1138
0.92
0.31
1.6
1.6
997.81
1019.92
mu/l
0.10
89
968
31
268
1.16
0.30
1.1
1.1
7.02
4.50
u/ml
0.38
19
142
38
334
1.14
0.30
2.1
2.1
3.07
3.69
iu/l
0.44
18
151
28
241
1.17
0.29
1.7
1.3
20.37
21.63
u/l
0.08
22
200
13
103
1.27
0.28
1.2
1.1
—
—
—
0
0
8
62
1.29
0.28
1.3
1.2
—
—
—
0
0
22
186
1.19
0.28
1.1
1.1
1.71
2.22
eliau/ml
0.26
11
89
8
64
1.25
0.27
1.3
1.0
—
—
—
0
0
34
300
1.14
0.26
10.0
3.5
—
—
—
0
0
198
1896
1.06
0.26
2.0
1.8
—
—
—
0
0
10
77
1.30
0.26
1.3
8.2
6.30
6.67
mmol/l
—
10
63
69
639
1.09
0.24
12.4
3.8
7.38
7.38
ph
0.34
38
355
32
284
1.13
0.24
1.1
1.2
—
—
—
0
0
5
39
1.28
0.23
1.0
1.6
—
—
—
0
0
5
39
1.28
0.23
1.2
1.2
148.80
100.22
nmol/l
—
5
30
54
586
0.92
0.22
1.2
1.7
—
—
—
0
0
67
623
1.08
0.22
12.6
3.7
1.86
1.69
mmol/l
0.14
61
535
35
315
1.12
0.21
1.5
1.3
—
—
—
0
0
16
135
1.19
0.21
1.9
2.4
40.60
120.87
ug/min
—
9
90
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
4.33
—
0
12
24
211
1.14
0.20
1.2
1.1
5.93
7.71
u/ml
0.22
13
91
10
123
0.81
0.20
2.7
2.7
6.90
7.26
mmol/l
—
10
117
13
155
0.84
0.20
2.4
2.6
1.54
1.48
mmol/l
0.08
13
148
34
307
1.11
0.20
1.2
1.1
2.07
3.08
u/ml
0.51
21
158
43
468
0.92
0.19
1.3
1.7
—
—
—
0
0
55
590
0.93
0.18
1.2
1.7
—
—
—
0
0
55
587
0.93
0.16
1.2
1.7
—
—
—
0
0
14
162
0.86
0.16
3.1
3.6
16.04
23.81
mg/l
—
7
108
51
545
0.93
0.16
1.2
1.7
—
—
—
0
0
55
585
0.94
0.15
1.2
1.7
—
—
—
0
0
28
255
1.10
0.15
1.1
1.1
0.86
1.65
u/ml
0.56
15
103
62
589
1.06
0.13
2.9
1.8
—
—
—
0
0
130
1261
1.04
0.12
1.8
1.8
3.25
3.27
ratio
0.04
91
934
46
434
1.06
0.12
1.4
1.2
—
—
—
0
0
21
193
1.09
0.10
1.1
1.1
—
—
—
0
0
5
46
1.09
0.09
1.4
1.7
—
—
—
0
0
6
54
1.11
0.09
1.3
1.1
—
—
—
0
0
7
64
1.09
0.08
1.0
1.2
—
—
—
0
0
7
65
1.08
0.08
1.1
1.1
303.14
302.64
mg/l
—
7
59
7
65
1.08
0.08
1.7
1.3
80.71
71.00
umol/l
—
7
65
7
65
1.08
0.08
2.4
2.0
1.18
1.20
mmol/l
—
7
65
7
66
1.06
0.08
2.4
2.1
105.43
106.50
mmol/l
—
7
66
7
66
1.06
0.08
2.4
2.1
3.86
3.93
mmol/l
—
7
66
8
75
1.07
0.07
1.9
2.5
—
—
—
0
0
8
78
1.03
0.07
1.4
1.1
—
—
—
0
0
14
153
0.91
0.07
1.1
1.7
7.12
7.73
mmol/l
0.44
14
148
47
453
1.04
0.06
1.1
1.1
1.62
1.59
g/l
0.32
47
453
41
395
1.04
0.05
14.3
9.4
0.76
0.63
%
1.13
41
395
10
91
1.10
0.04
2.2
2.3
—
—
—
0
0
47
483
0.97
0.04
1.1
1.1
—
—
—
0
0
224
2220
1.01
0.04
5.3
4.0
12.54
8.21
mg/mmol
0.82
135
1345
112
1104
1.02
0.04
1.3
1.3
—
—
—
0
0
68
693
0.98
0.03
11.0
9.0
1.52
0.89
mmol/l
0.54
56
575
124
1255
0.99
0.03
1.7
1.9
—
—
—
0
0
18
171
1.05
0.03
1.6
1.8
127.08
129.78
g/l
0.31
12
139
38
390
0.97
0.03
2.9
2.6
1.01
1.02
ratio
0.52
31
356
255
2560
0.99
0.01
4.4
3.3
7.15
7.50
mmol/l
0.65
218
2221
220
2193
1.00
0.00
4.5
3.4
74.27
43.33
mg/l
1.21
129
1357
43
424
1.01
0.00
1.3
2.2
—
—
—
0
0
33
334
0.99
0.00
3.8
7.9
—
—
—
0
0
98
976
1.00
0.00
1.6
1.7
3.59
3.40
mmol/l
0.72
67
659
41
409
1.00
0.00
13.9
9.2
1.19
1.24
%
0.22
41
409
70
699
1.00
0.00
11.4
9.0
7.41
7.41
ph
0.31
32
387
66
661
1.00
0.00
2.0
4.1
34.61
7.41
ug/l
0.42
47
510
18
175
1.03
0.00
1.7
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
317.67
—
0
6
0
5
0.00
-0.00
0.0
7.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
66
0.91
-0.00
3.0
2.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
64.86
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
72
720
1.00
-0.00
1.7
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
4.56
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
69
1.01
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_PERIORALDERM and mortality.

Females

Parameter HR [95% CI] p-value
L12_PERIORALDERM 0.904 [0.74, 1.1] 0.316
Birth year 0.996 [0.99, 1.0] 0.35

During the follow-up period (1.1.1998 — 31.12.2019), 136 out of 2529 females with L12_PERIORALDERM died.

Males

Parameter HR [95% CI] p-value
L12_PERIORALDERM 1.434 [1.09, 1.89] 0.011
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 585 males with L12_PERIORALDERM died.

Mortality risk

Mortality risk for people of age

years, who have L12_PERIORALDERM.

N-year risk Females Males
1 0.089% 0.262%
5 0.583% 1.442%
10 1.383% 3.6%
15 2.476% 7.047%
20 4.8% 12.19%

Relationships between endpoints

Index endpoint: L12_PERIORALDERM – Perioral dermatitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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