Haemolytic anaemias

D3_HAEMOLYTICANAEMIA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

1556

6. Filter based on genotype QC (FinnGen only)

1241

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12357 6434 5535
Only index persons 8979 4855 4124
Unadjusted period prevalence (%)
Whole population 0.18 0.18 0.15
Only index persons 0.17 0.18 0.16
Median age at first event (years)
Whole population 51.74 53.46 50.94
Only index persons 47.59 47.37 47.84

-FinnGen-

Key figures

All Female Male
Number of individuals 1241 643 598
Unadjusted period prevalence (%) 0.25 0.23 0.27
Median age at first event (years) 58.68 53.40 64.36

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1398
Matched controls
13980
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
307.7
442
*
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
305.8
282
*
D64.9
ICD-10 Finland
Anaemia, unspecified
7.4
255.6
474
904
XW000
NOMESCO Finland
Bone marrow biopsy
12.7
243.8
258
245
WW500
NOMESCO Finland
Blood transfusion
8.7
154.0
212
282
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.4
123.4
399
1171
TK800
NOMESCO Finland
Hemodialysis
11.2
105.6
115
111
L04AA06
ATC
mycophenolic acid; systemic
12.4
105.3
107
93
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
10.4
102.6
118
123
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
18.2
99.6
81
47
127
Kela drug reimbursment
Transplant complication
12.6
90.0
90
76
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
22.7
88.2
65
30
Z94.0
ICD-10 Finland
Kidney transplant status
16.0
87.6
76
50
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
9.0
84.2
107
127
B03XA02
ATC
darbepoetin alfa; parenteral
9.3
83.7
104
120
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.0
81.8
154
282
D58.2
ICD-10 Finland
Other haemoglobinopathies
+∞
80.0
76
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
19.4
79.9
63
34
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
25.3
79.4
56
23
D58.0
ICD-10 Finland
Hereditary spherocytosis
+∞
76.8
73
*
ZX120
NOMESCO Finland
Intravenous
4.0
75.7
250
726
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
74.7
71
*
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
14.9
74.5
67
47
Z49.1
ICD-10 Finland
Extracorporeal dialysis
12.3
73.5
74
63
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
19.8
73.1
57
30
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
14.5
65.9
60
43
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
65.7
551
2737
D59.8
ICD-10 Finland
Other acquired haemolytic anaemias
+∞
65.1
62
*
B03XA01
ATC
erythropoietin; parenteral
13.9
64.2
60
45
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
64.1
607
3189
A11CC03
ATC
alfacalcidol; systemic
7.2
63.8
98
145
D59.3
ICD-10 Finland
Haemolytic-uraemic syndrome
+∞
63.0
60
*
A12AA04
ATC
calcium carbonate; oral
9.3
61.9
76
86
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
10.8
61.9
68
66
D64.8
ICD-10 Finland
Other specified anaemias
8.0
61.2
85
112
L04AD02
ATC
tacrolimus; systemic
12.5
61.2
61
51
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
20.2
60.9
47
24
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
60.3
821
5064
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
17.2
60.2
50
30
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.6
59.5
151
357
V03AE02
ATC
sevelamer; oral
27.4
58.4
40
15
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.1
57.8
173
464
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.6
57.7
219
692
N18.0
ICD-10 Finland
End-stage renal disease
12.9
57.5
56
45
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
8.0
56.5
78
102
H02AB06
ATC
prednisolone; systemic
2.4
56.0
785
4846
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
13.0
55.7
54
43
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.6
55.5
207
646
L04AD01
ATC
ciclosporin; systemic
8.6
53.9
70
85
N08.2*D59.3
ICD-10 Finland
Glomerular disorders in haemolytic-uraemic syndrome
+∞
52.4
50
*
D56.0
ICD-10 Finland
Alpha thalassaemia
+∞
49.3
47
*
V03AE01
ATC
polystyrene sulfonate; oral
9.3
49.2
60
67
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
6.4
47.3
81
134
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
46.5
416
2071
M04AA01
ATC
allopurinol; systemic
2.9
46.5
266
1064
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
6.4
45.0
76
124
C03CA01
ATC
furosemide; systemic
2.3
44.6
544
3082
D59.0
ICD-10 Finland
Drug-induced autoimmune haemolytic anaemia
+∞
42.9
41
*
D57.3
ICD-10 Finland
Sickle-cell trait
+∞
42.9
41
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.5
42.8
157
482
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
41.8
325
1508
JMA10
NOMESCO Finland
Transabdominal total splenectomy
14.6
40.9
37
26
D56.3
ICD-10 Finland
Thalassaemia trait
+∞
40.8
39
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.0
40.2
55
71
L04AX01
ATC
azathioprine; systemic
4.5
39.9
100
233
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.4
39.7
341
1651
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
12.6
37.6
37
30
1XC02, ,
NOMESCO Finland
13.8
37.5
35
26
UJF32
NOMESCO Finland
Coloscopy
2.2
37.2
431
2358
137
Kela drug reimbursment
Uraemia requiring dialysis
10.5
36.1
40
39
L04AA01
ATC
[U] ciclosporin
9.2
36.1
44
49
D56.99
ICD-10 Finland
Thalassaemia, unspecified
+∞
35.6
34
*
R50.9
ICD-10 Finland
Fever, unspecified
2.4
34.8
292
1392
28200
ICD-8 Finland
Hereditary haemolytic anaemias, Familial acholuric jaundice
+∞
34.5
33
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.5
34.4
87
204
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
10.5
34.3
38
37
Z49.0
ICD-10 Finland
Preparatory care for dialysis
10.0
34.0
39
40
D70.89
ICD-10 Finland
Neutropenic splenomegaly
8.5
34.0
44
53
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
7.4
33.6
49
68
N08.2*D57.8
ICD-10 Finland
Glomerular disorders in sickle-cell disorders
+∞
33.5
32
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
33.3
220
937
JN4AD
NOMESCO Finland
Body CT examination
2.6
32.8
219
937
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
50.1
32.6
39
8
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.8
31.8
103
290
3AC01, ,
NOMESCO Finland
8.9
31.1
39
45
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
30.8
442
2592
N18.8
ICD-10 Finland
Other chronic renal failure
5.0
30.0
65
134
H02AB07
ATC
prednisone; oral
2.4
29.8
234
1077
D50.8
ICD-10 Finland
Other iron deficiency anaemias
6.6
29.6
48
75
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.7
29.4
69
152
D56.91
ICD-10 Finland
Thalassemia minor
+∞
29.3
28
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.1
29.0
131
455
D56.1
ICD-10 Finland
Beta thalassaemia
297.9
28.9
29
*
A02BC02
ATC
pantoprazole; systemic
2.0
28.6
969
7490
D59.5
ICD-10 Finland
Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
+∞
28.2
27
*
Z49.2
ICD-10 Finland
Other dialysis
10.5
28.1
31
30
B05DB
ATC
Hypertonic solutions
10.9
27.8
30
28
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.4
27.7
102
312
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
7.4
26.8
39
54
ZXD05
NOMESCO Finland
Urgent procedure
1.9
26.3
464
2891
2839X
ICD-9 Finland
Acquired haemolytic anaemias, Acquired haemolytic anaemia, unspecified
+∞
26.1
25
*
B01AA03
ATC
warfarin; systemic
2.1
25.9
312
1702
WW400
NOMESCO Finland
Plasmaferesis
95.2
25.7
28
*
Z3231
NOMESCO Finland
Registered nurse
1.9
25.7
436
2679
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
33.8
25.6
33
10
ZX108
NOMESCO Finland
Inhalation
8.6
24.9
32
38
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.7
24.9
82
233
WW200
NOMESCO Finland
Immunization
4.4
24.9
64
152
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
91.8
24.7
27
*
B05DA
ATC
Isotonic solutions
9.5
24.5
29
31
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
6.9
23.4
36
53
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
23.4
347
2029
B03BA03
ATC
hydroxocobalamin; parenteral
3.0
23.3
109
385
JN4BD
NOMESCO Finland
Extensive body CT
2.4
23.1
172
768
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
5.6
23.0
44
81
D58.9
ICD-10 Finland
Hereditary haemolytic anaemia, unspecified
+∞
23.0
22
*
2830A
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA PRIMARIA]
+∞
23.0
22
*
Z31.5
ICD-10 Finland
Genetic counselling
3.0
22.7
102
352
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
6.0
22.7
40
68
H02AB04
ATC
methylprednisolone; systemic
2.2
22.5
222
1116
B82
ICPC
Anaemia other/unspecified
3.7
22.5
72
201
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.8
21.6
111
413
Z2221
NOMESCO Finland
Medical doctor
1.8
21.5
405
2546
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.8
21.4
67
184
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.7
21.2
121
476
D59.6
ICD-10 Finland
Haemoglobinuria due to haemolysis from other external causes
+∞
20.9
20
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
6.3
20.7
35
57
L03AA02
ATC
filgrastim; parenteral
3.9
20.5
62
166
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
20.2
242
1306
321
Kela drug reimbursment
Paricalcitol and cinacalcet
8.5
20.2
26
31
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
20.1
254
1397
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
19.9
194
969
TGC00
NOMESCO Finland
Bronchial lavation
3.9
19.7
59
157
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.9
19.5
95
343
R4110
NOMESCO Finland
Physiotherapy
1.8
19.5
409
2644
GD1AD
NOMESCO Finland
Thorax CT examination
2.6
19.4
116
467
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.1
19.3
85
290
196
Kela drug reimbursment
Paricalcitol and cinacalcet
15.8
19.3
31
20
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
8.5
19.3
25
30
H02AB09
ATC
hydrocortisone; systemic
3.9
19.2
57
151
6BA02, ,
NOMESCO Finland
26.5
19.2
26
10
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
18.9
371
2347
D55.9
ICD-10 Finland
Anaemia due to enzyme disorder, unspecified
+∞
18.8
18
*
2820A
ICD-9 Finland
Hereditary haemolytic anaemias, Hereditary spherocytosis
+∞
18.8
18
*
J01MA12
ATC
levofloxacin; systemic
1.9
18.6
275
1592
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
18.4
200
1040
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
18.3
214
1144
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
5.3
18.2
37
72
R06.0
ICD-10 Finland
Dyspnoea
1.7
18.2
407
2671
UJF92
NOMESCO Finland
Capsular endoscopy
4.2
18.1
48
117
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
23.1
17.8
25
11
D59.2
ICD-10 Finland
Drug-induced nonautoimmune haemolytic anaemia
+∞
17.7
17
*
M31.1
ICD-10 Finland
Thrombotic microangiopathy
182.2
17.5
18
*
B01AB05
ATC
enoxaparin; parenteral
1.7
17.5
438
2957
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
13.3
17.5
30
23
UJF30
NOMESCO Finland
Ileoscopy through colon
2.2
17.3
160
782
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
6.7
17.1
27
41
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
7.6
17.0
24
32
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.5
17.0
111
466
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
25.9
16.9
23
9
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
5.4
16.9
33
62
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
4.1
16.8
47
119
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
6.0
16.5
29
49
J01MA14
ATC
moxifloxacin; systemic
2.2
16.5
140
659
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.5
16.4
111
473
ZXE00
NOMESCO Finland
One hour or less
1.6
16.4
538
3880
J01FF01
ATC
clindamycin; systemic
1.7
16.2
370
2428
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
13.0
16.2
28
22
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.6
16.0
52
147
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
3.7
15.9
50
138
WX892
NOMESCO Finland
Monitored bed care
2.3
15.9
131
610
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.2
15.9
146
711
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
15.9
273
1652
WX872
NOMESCO Finland
Intensive care
2.7
15.8
88
341
B01AB10
ATC
tinzaparin; parenteral
2.1
15.7
169
874
A41.9
ICD-10 Finland
Sepsis, unspecified
3.1
15.7
67
225
D57.1
ICD-10 Finland
Sickle-cell anaemia without crisis
+∞
15.7
15
*
C07AB07
ATC
bisoprolol; oral
1.6
15.4
665
5097
K83
ICPC
Heart valve disease NOS
5.8
15.4
28
49
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
15.4
283
1745
A10AC01
ATC
insulin (human); parenteral
2.3
15.2
125
581
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
13.2
15.2
26
20
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
15.2
171
899
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
15.0
486
3476
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.7
15.0
79
298
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.0
15.0
67
231
JN3AD
NOMESCO Finland
Abdominal CT examination
2.0
14.9
190
1042
J05AB11
ATC
valaciclovir; oral
1.9
14.9
210
1192
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.4
14.9
54
164
C09AA02
ATC
enalapril; systemic
1.8
14.8
271
1666
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.8
14.8
74
271
N02AX02
ATC
tramadol; systemic, rectal
1.6
14.8
568
4226
I50.0
ICD-10 Finland
Congestive heart failure
2.2
14.8
126
594
6753
FHL
Transabdominal splenectomy
57.3
14.8
17
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
14.8
341
2238
D58.1
ICD-10 Finland
Hereditary elliptocytosis
+∞
14.6
14
*
D58.8
ICD-10 Finland
Other specified hereditary haemolytic anaemias
+∞
14.6
14
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
14.5
152
778
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
15.6
14.4
23
15
A46
ICD-10 Finland
Erysipelas
1.9
14.4
212
1219
V03AE03
ATC
lanthanum carbonate; oral
13.5
14.2
24
18
L01AA01
ATC
cyclophosphamide; systemic
14.6
14.1
23
16
PJA10
NOMESCO Finland
Exploration of lymph nodes
4.9
14.1
31
65
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
5.9
14.0
25
43
L01AA02
ATC
chlorambucil; oral
15.9
13.9
22
14
WZC00
NOMESCO Finland
Treatment plan or consultation
1.6
13.9
502
3670
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.8
13.9
42
113
M05BA04
ATC
alendronic acid; oral
2.1
13.8
131
646
J01MA02
ATC
ciprofloxacin; systemic
1.6
13.7
513
3780
TPH40
NOMESCO Finland
Insertion of a long peripheral venous catheter
6.6
13.7
22
34
D56.2
ICD-10 Finland
Delta-beta thalassaemia
+∞
13.6
13
*
V03AC03
ATC
deferasirox; oral
141.3
13.5
14
*
K92.1
ICD-10 Finland
Melaena
2.4
13.4
93
401
SPAT1255
SPAT
Intravenous administration of medicine
2.3
13.4
104
472
WX882
NOMESCO Finland
High dependency care
2.9
13.4
61
213
Z2446
NOMESCO Finland
Social worker
2.2
13.2
115
547
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
13.2
195
1121
A10AB05
ATC
insulin aspart; parenteral
2.2
13.2
119
574
A02BC01
ATC
omeprazole; systemic
1.6
12.9
365
2512
JN6AD
NOMESCO Finland
CT of torso and neck
4.1
12.9
35
87
E87.5
ICD-10 Finland
Hyperkalaemia
3.7
12.8
40
110
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
12.7
560
4260
122
Kela drug reimbursment
Aplastic anaemia
70.5
12.6
14
*
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
70.5
12.6
14
*
28390
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria primaria
+∞
12.5
12
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.6
12.5
313
2087
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.0
12.4
55
189
AA1AD
NOMESCO Finland
CT of head and brain
1.6
12.3
400
2840
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
12.2
480
3553
TPH07
NOMESCO Finland
Cathetrisation of artery
1.9
12.2
171
967
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
2.9
12.2
57
202
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.6
12.1
70
277
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
18.2
12.1
18
10
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
18.2
12.1
18
10
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
26.9
12.1
16
6
SPAT1088
SPAT
Blood transfusion
11.2
12.0
22
20
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
21.5
12.0
17
8
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.4
12.0
86
377
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
11.9
494
3693
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.1
11.9
49
161
C90.0
ICD-10 Finland
Multiple myeloma
4.9
11.9
26
54
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.7
11.9
247
1566
B01AB04
ATC
dalteparin; parenteral
2.5
11.8
77
323
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
5.9
11.8
21
36
WX203
NOMESCO Finland
Infraclavicular plexus blockade
3.6
11.8
38
107
A04AA01
ATC
ondansetron; systemic, rectal
2.1
11.8
122
621
C08CA01
ATC
amlodipine; oral
1.5
11.7
505
3804
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
19.1
11.6
17
9
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
23.1
11.6
16
7
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
3.5
11.6
40
118
H05BX01
ATC
cinacalcet; oral
8.7
11.5
24
28
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
10.1
11.5
22
22
28398
ICD-8 Finland
Acquired haemolytic anaemias, Aliae definitar
+∞
11.5
11
*
D73.0
ICD-10 Finland
Hyposplenism
121.0
11.4
12
*
A05AA02
ATC
ursodeoxycholic acid; oral
4.0
11.3
32
82
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
15.2
11.3
18
12
L01XX52
ATC
venetoclax; oral
17.2
11.2
17
10
S97
ICPC
Chronic ulcer skin
2.2
11.2
100
481
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.0
11.2
132
704
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
11.2
224
1406
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
20.2
11.1
16
8
B81
ICPC
Anaemia vit B12/folate deficiency
2.6
11.1
63
247
ZX112
NOMESCO Finland
Subcutaneous
3.3
11.0
41
127
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
12.0
10.8
19
16
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
8.3
10.8
23
28
WX002
NOMESCO Finland
Sedation and analgesia
1.6
10.8
257
1686
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
8.9
10.8
22
25
K29.7
ICD-10 Finland
Gastritis, unspecified
2.7
10.8
57
216
R31
ICD-10 Finland
Unspecified haematuria
1.8
10.8
155
883
C03DA01
ATC
spironolactone; oral
1.8
10.7
179
1066
Z99.2
ICD-10 Finland
Dependence on renal dialysis
28.3
10.7
14
5
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
2.5
10.7
67
276
R4190
NOMESCO Finland
Nutritional therapy
2.4
10.7
72
307
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
10.7
690
5603
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.9
10.6
129
695
D45
ICD-10 Finland
Polycythaemia vera
5.1
10.5
22
44
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
2.8
10.5
52
190
C08CA05
ATC
nifedipine; systemic
2.2
10.4
89
420
D56
ICD-10 Finland
Thalassaemia
110.8
10.4
11
*
D55.0
ICD-10 Finland
Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
+∞
10.4
10
*
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
5.5
10.4
20
37
D64
ICD-10 Finland
Other anaemias
32.8
10.3
13
*
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
3.4
10.3
37
112
120
Kela drug reimbursment
Hypogammaglobulinaemia
23.5
10.2
14
6
A12AA12
ATC
[U] calcium acetate
23.5
10.2
14
6
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.3
10.2
77
345
J94.8
ICD-10 Finland
Other specified pleural conditions
3.9
10.1
29
75
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.0
10.1
106
543
TK810
NOMESCO Finland
Hemofiltration
8.5
10.1
21
25
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.4
10.0
68
291
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
3.7
10.0
31
85
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
7.7
9.9
22
29
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
26.2
9.8
13
5
205
Kela drug reimbursment
Chronic hypertension
1.5
9.8
341
2439
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
4.7
9.8
22
47
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
2.8
9.8
48
175
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
9.6
9.8
19
20
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
9.6
9.8
19
20
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.8
9.7
151
880
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
7.4
9.7
22
30
RS221, ,
NOMESCO Finland
3.9
9.7
28
73
RS220, ,
NOMESCO Finland
3.9
9.7
28
73
399
Kela drug reimbursment
Venetoclax
13.5
9.7
16
12
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
55.4
9.7
11
*
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
2.9
9.7
44
154
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.4
9.6
67
291
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.2
9.5
83
396
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.6
9.5
291
2024
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
3.7
9.5
29
79
N08.2*D89.82
ICD-10 Finland
Nepropathy caused by deposition of the light chain of the immunoglobulins
100.7
9.4
10
*
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
17.7
9.4
14
8
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.3
9.4
71
319
D57.0
ICD-10 Finland
Sickle-cell anaemia with crisis
+∞
9.4
9
*
28299
ICD-8 Finland
Hereditary haemolytic anaemias, Other
+∞
9.4
9
*
C01BD01
ATC
amiodarone; systemic
2.9
9.3
42
146
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.8
9.3
141
815
I50.1
ICD-10 Finland
Left ventricular failure
2.2
9.3
75
347
RD210, ,
NOMESCO Finland
3.3
9.2
34
105
I34.1
ICD-10 Finland
Mitral (valve) prolapse
2.8
9.2
45
164
N02AA05
ATC
oxycodone; systemic
1.6
9.1
248
1676
107
Kela drug reimbursment
Pernicious anaemia
3.5
9.1
31
91
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
2.7
9.1
46
171
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.5
9.1
372
2748
C07AB02
ATC
metoprolol; systemic
1.6
9.0
263
1805
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
2.3
9.0
64
280
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
2.5
9.0
56
231
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.7
8.9
172
1065
PBU84
NOMESCO Finland
Plastic repair of arteriovenous fistula from artery of upper extremity
18.7
8.9
13
7
N19
ICD-10 Finland
Unspecified kidney failure
2.4
8.9
60
256
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.1
8.9
36
118
A10AE04
ATC
insulin glargine; parenteral
1.8
8.7
131
757
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
3.8
8.6
26
70
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.4
8.6
56
236
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
3.2
8.5
33
105
A02BC05
ATC
esomeprazole; systemic
1.4
8.5
490
3850
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
27.7
8.5
11
*
V03AE04
ATC
calcium acetate and magnesium carbonate; systemic
27.7
8.5
11
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
90.6
8.4
9
*
D46.0
ICD-10 Finland
Refractory anaemia without ring sideroblasts, so stated
90.6
8.4
9
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
90.6
8.4
9
*
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.5
8.4
20
45
R1240
NOMESCO Finland
Social assessment of need and possibilities of rehabilitation
4.9
8.4
18
37
A07AA09
ATC
vancomycin; oral
3.8
8.4
25
67
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
4.0
8.3
23
58
2830X
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA NUD]
+∞
8.3
8
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.3
8.3
62
277
C09CA06
ATC
candesartan; oral
1.5
8.3
291
2076
B80
ICPC
Iron deficiency anaemia
2.7
8.3
42
156
A12BA01
ATC
potassium chloride; oral
2.3
8.3
63
284
TKC20
NOMESCO Finland
Catheterisation of bladder
2.0
8.2
95
503
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.3
8.2
63
285
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.1
8.2
82
412
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
2.7
8.2
43
163
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
7.6
8.2
18
24
R60.0
ICD-10 Finland
Localized oedema
1.7
8.2
165
1035
WVA20
NOMESCO Finland
Medicine administration
2.6
8.1
46
181
A41.8
ICD-10 Finland
Other specified sepsis
3.0
8.1
34
114
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
22.2
8.0
11
5
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
3.7
7.9
24
65
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
3.6
7.9
25
70
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
7.8
255
1790
C02CA01
ATC
prazosin; oral
3.3
7.8
29
90
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
8.5
7.8
16
19
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
2.8
7.8
39
144
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
10.9
7.8
14
13
Z94.4
ICD-10 Finland
Liver transplant status
9.5
7.8
15
16
Z3226
NOMESCO Finland
Physiotherapist
1.5
7.7
236
1633
J01DB01
ATC
cefalexin; oral
1.5
7.7
1078
9768
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
6.4
7.7
19
30
C83.00
ICD-10 Finland
Lymphocytic lymphoma
15.1
7.7
12
8
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.7
7.7
133
799
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.4
7.7
52
223
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
3.4
7.7
27
81
WZC30
NOMESCO Finland
Teaching
1.6
7.6
208
1403
RS222, ,
NOMESCO Finland
3.8
7.6
23
62
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
18.5
7.6
11
6
A07AA02
ATC
nystatin; oral
2.0
7.6
77
390
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.6
7.4
173
1126
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
13.4
7.4
12
9
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
2.5
7.4
44
178
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.0
7.3
74
374
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
3.0
7.3
32
110
1518, ,
Kela drug reimbursment
10.9
7.3
13
12
D56.8
ICD-10 Finland
Other thalassaemias
+∞
7.3
7
*
N08.2*D65
ICD-10 Finland
Glomerular disorders in disseminated intravascular coagulation [defibrination syndrome]
+∞
7.3
7
*
K92.0
ICD-10 Finland
Haematemesis
2.7
7.3
37
138
AC4
HP
MVP
9.4
7.3
14
15
L04AA05
ATC
[U] tacrolimus
15.8
7.2
11
7
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
2.5
7.2
43
174
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.7
7.2
138
855
C91.7
ICD-10 Finland
Other lymphoid leukaemia
30.2
7.2
9
*
B02BX05
ATC
eltrombopag; oral
30.2
7.2
9
*
H05BX02
ATC
paricalcitol; systemic
20.1
7.1
10
5
WX202
NOMESCO Finland
Supraclavicular plexus blockade
3.4
7.1
25
75
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
12.1
7.1
12
10
5AB14, ,
NOMESCO Finland
12.1
7.1
12
10
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
7.1
226
1579
I50
ICD-10 Finland
Heart failure
2.3
7.1
49
213
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
1.8
7.0
105
605
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
2.8
7.0
33
118
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
3.1
7.0
28
91
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
4.2
7.0
18
43
UKC02
NOMESCO Finland
Cystoscopy
1.5
7.0
205
1405
C07AG02
ATC
carvedilol; oral
1.9
7.0
80
423
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.6
7.0
184
1231
D86.0
ICD-10 Finland
Sarcoidosis of lung
3.9
7.0
20
52
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.5
6.9
286
2102
R80
ICD-10 Finland
Isolated proteinuria
5.9
6.9
18
31
XG410
NOMESCO Finland
Flow-volume spirometry
2.2
6.9
55
254
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.7
6.9
121
731
T81.9
ICD-10 Finland
Unspecified complication of procedure
3.0
6.9
30
103
104
Kela drug reimbursment
Thyroid insufficiency
1.9
6.8
88
484
R53
ICD-10 Finland
Malaise and fatigue
1.4
6.8
333
2523
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
2.8
6.8
33
120
J01CA04
ATC
amoxicillin; systemic
1.4
6.8
1078
9845
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
40.3
6.8
8
*
1AA09, ,
NOMESCO Finland
40.3
6.8
8
*
L01BB05
ATC
fludarabine; systemic
16.8
6.7
10
6
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
7.2
6.7
15
21
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
3.3
6.7
24
73
A06AD11
ATC
lactulose; oral
1.5
6.7
190
1293
WX402
NOMESCO Finland
General anaesthesia
1.5
6.7
272
1993
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
22.6
6.7
9
*
7151
FHL
Kidney transplantation
22.6
6.7
9
*
PG1XE
NOMESCO Finland
Other ultrasound examination of blood vessel not elsewhere classified
5.5
6.6
18
33
212
Kela drug reimbursment
Gout
2.9
6.6
29
100
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.6
6.6
137
866
C08DB01
ATC
diltiazem; oral
2.0
6.5
72
376
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
2.2
6.5
55
260
FKC50
NOMESCO Finland
Repair of mitral valve for insufficiency using prosthetic chord
6.9
6.5
15
22
P01AB01
ATC
metronidazole; oral, rectal
1.4
6.5
466
3760
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.8
6.5
88
493
TK820
NOMESCO Finland
Peritoneal dialysis
6.2
6.5
16
26
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
5.3
6.5
18
34
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
5.3
6.5
18
34
B34.9
ICD-10 Finland
Viral infection, unspecified
2.4
6.5
44
190
L03AA13
ATC
pegfilgrastim; parenteral
2.1
6.4
59
288
C93.1
ICD-10 Finland
Chronic myelomonocytic leukaemia
70.2
6.4
7
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.7
6.4
118
722
JJC00
NOMESCO Finland
Allogenic transplantation of liver
14.4
6.4
10
7
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
14.4
6.4
10
7
H03AA01
ATC
levothyroxine sodium; systemic
1.4
6.4
273
2019
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.8
6.4
102
601
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
2.7
6.3
33
125
K55.8
ICD-10 Finland
Other vascular disorders of intestine
8.2
6.3
13
16
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
8.2
6.3
13
16
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.5
6.3
201
1401
P01BA02
ATC
hydroxychloroquine; oral
1.8
6.3
95
549
C02AC05
ATC
moxonidine; oral
2.0
6.3
64
325
C88.0
ICD-10 Finland
Waldenström macroglobulinaemia
11.1
6.3
11
10
L01XX05
ATC
hydroxycarbamide; oral
3.5
6.3
21
61
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
9.3
6.3
12
13
28391
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria secundaria
+∞
6.3
6
*
D55.2
ICD-10 Finland
Anaemia due to disorders of glycolytic enzymes
+∞
6.3
6
*
D61.0
ICD-10 Finland
Constitutional aplastic anaemia
+∞
6.3
6
*
4AA25, ,
NOMESCO Finland
+∞
6.3
6
*
AC1
HP
MVR mechanical
26.8
6.2
8
*
2873A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[PURPURA THROMBOCYTOPENICA IDIOPATHICA (ITP)]
26.8
6.2
8
*
B28
ICPC
Limited function/disability (B)
7.1
6.2
14
20
A40.8
ICD-10 Finland
Other streptococcal sepsis
3.7
6.2
19
52
XX9XW, ,
NOMESCO Finland
5.8
6.1
16
28
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.8
6.1
84
472
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.3
6.1
45
201
F43.29
ICD-10 Finland
Adaptation disorder UNS
2.6
6.1
34
134
D68.8
ICD-10 Finland
Other specified coagulation defects
3.6
6.0
19
53
AB2
HP
AVR bio, stent
6.7
6.0
14
21

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
235
114
24.58
318.42
1.4
1.1
—
—
—
0
0
640
560
20.23
307.65
7.6
1.6
0.89
1.53
g/l
30.12
472
502
466
287
23.86
307.65
4.5
1.5
—
—
—
0
0
684
1144
10.75
307.65
14.1
2.4
116.70
68.31
e9/l
31.65
535
849
798
1484
11.20
307.65
14.5
2.5
3.15
1.76
%
49.18
761
1336
218
188
13.55
218.38
1.6
1.7
—
—
—
0
0
683
2127
5.32
210.24
5.1
2.6
14.84
12.83
umol/l
6.66
648
1988
657
1995
5.33
208.19
5.0
2.6
2.20
2.31
g/l
5.47
623
1854
619
1845
5.23
199.20
5.2
2.6
27.33
22.44
%
8.96
596
1727
409
995
5.40
163.99
4.9
2.8
10.08
10.67
g/l
1.03
391
921
359
792
5.75
160.55
2.7
1.7
1.64
1.34
g/l
1.14
334
732
159
135
13.16
159.74
1.4
1.4
—
—
—
0
0
121
65
20.28
154.97
4.9
2.2
121.02
68.35
mg/l
2.08
111
48
251
407
7.30
153.20
3.2
3.7
49.47
62.85
mg/l
0.37
220
349
250
407
7.26
151.97
3.2
3.7
34.74
56.36
mg/l
1.07
219
351
793
3411
4.06
146.32
3.7
2.3
3.86
2.83
mg/l
14.00
724
2945
230
368
7.28
141.73
3.2
3.5
5.89
2.35
ratio
0.48
136
221
393
1036
4.89
141.28
3.4
2.8
65.40
66.39
g/l
1.33
377
949
78
13
63.49
140.70
1.8
1.4
—
—
—
0
0
344
824
5.21
138.61
3.2
2.5
—
—
—
0
0
181
265
7.70
120.31
1.6
1.5
—
—
—
0
0
243
492
5.77
117.33
3.1
2.2
3.28
3.74
g/l
2.93
232
447
243
493
5.76
117.06
3.1
2.2
5.95
7.47
g/l
28.96
232
447
243
493
5.76
117.06
3.1
2.2
3.93
4.20
g/l
4.46
232
447
232
460
5.85
114.46
3.2
2.3
2.86
3.04
g/l
1.72
221
414
436
1436
3.96
113.95
2.1
1.6
—
—
—
0
0
176
265
7.45
113.93
2.1
1.6
—
—
—
0
0
213
391
6.25
113.91
6.2
2.9
3.19
3.58
g/l
3.05
208
372
842
4225
3.50
113.64
15.2
6.2
—
—
—
0
0
431
1431
3.91
111.01
5.6
2.9
11.85
7.84
umol/l
2.70
400
1271
173
264
7.34
110.54
1.4
1.4
264.35
232.13
u/ml
0.57
112
151
117
109
11.62
110.09
1.2
1.3
—
—
—
0
0
338
953
4.36
109.11
1.7
1.5
—
—
—
0
0
1004
5868
3.52
100.60
15.3
6.3
57.61
57.19
%
0.43
979
5619
160
248
7.16
100.55
1.7
1.5
140.98
147.71
au/ml
0.24
45
76
1047
6292
3.64
99.97
15.3
6.2
0.04
0.04
e9/l
0.95
948
5380
1046
6283
3.64
99.93
15.3
6.2
0.60
0.59
e9/l
0.59
949
5371
470
1757
3.52
99.81
15.1
6.4
1.12
1.06
mmol/l
3.18
451
1635
1058
6413
3.67
99.32
15.4
6.2
2.19
1.93
e9/l
0.98
972
5636
998
5844
3.47
98.97
16.1
6.4
8.89
8.83
%
0.21
972
5491
994
5833
3.44
97.65
16.0
6.3
2.48
2.86
%
6.47
967
5477
132
173
8.32
96.07
10.8
1.8
1.50
0.89
%
6.43
111
122
504
2008
3.36
96.06
2.2
1.7
—
—
—
0
0
990
5830
3.39
95.94
16.2
6.4
0.66
0.66
%
0.11
961
5472
1058
6487
3.59
95.82
16.3
6.5
0.17
0.19
e9/l
7.12
975
5647
206
431
5.43
95.15
3.3
2.3
10.05
10.72
g/l
0.87
194
383
1044
6366
3.53
95.03
18.0
6.5
18.27
12.43
umol/l
16.99
1024
6076
1003
5982
3.39
94.50
16.1
6.4
27.85
27.69
%
0.14
980
5689
990
5865
3.36
94.22
7.3
3.1
317.58
122.17
ug/l
7.90
949
5475
146
220
7.29
94.04
1.7
1.2
58.02
35.29
u/l
0.93
134
191
1092
6984
3.57
88.88
22.0
9.3
4.22
4.14
e9/l
0.21
986
6071
201
441
5.16
87.68
1.4
1.4
—
—
—
0
0
117
153
8.25
85.15
10.2
1.9
33.01
32.31
pg
0.73
117
153
177
367
5.38
82.20
3.5
1.5
0.20
0.24
g/l
6.66
162
351
470
1945
3.13
82.02
4.7
2.2
29.99
29.66
s
0.40
461
1882
179
376
5.31
81.91
3.4
1.5
1.02
1.21
g/l
10.75
171
357
916
5438
2.99
81.82
11.2
5.3
35.36
35.53
g/l
0.36
882
5109
529
2381
2.97
78.97
2.3
2.0
—
—
—
0
0
187
426
4.91
77.72
9.9
7.0
1.65
1.50
mg/l
1.49
181
386
338
1187
3.44
77.01
18.0
7.9
12.39
9.83
mmol/l
4.59
331
1141
691
3638
2.78
75.86
2.4
1.7
22.69
20.36
nmol/l
1.47
633
3094
196
473
4.66
75.85
6.1
2.4
21.76
20.98
s
1.25
185
430
606
3055
2.74
71.39
5.2
2.8
364.96
347.09
umol/l
3.31
559
2689
403
1642
3.04
70.87
1.7
1.3
589.17
472.25
titre
0.64
96
351
902
5602
2.72
68.72
16.8
7.2
1.21
1.21
mmol/l
0.49
863
5184
469
2130
2.81
66.95
2.1
1.7
1345.41
1182.42
nmol/l
2.25
381
1620
462
2087
2.81
66.57
6.2
3.8
0.82
0.82
mmol/l
0.00
445
1965
960
6227
2.73
65.66
18.5
7.8
1.21
1.21
mmol/l
1.71
865
5399
668
3692
2.55
63.16
12.1
4.2
7.39
7.40
ph
0.35
533
2683
139
293
5.16
62.94
1.4
1.2
—
—
—
0
0
706
4027
2.52
62.07
7.3
2.5
—
—
—
0
0
588
3117
2.53
60.03
9.8
4.3
85.38
88.04
%
1.47
581
3056
857
5420
2.50
59.11
3.0
2.2
94.30
95.75
pmol/l
0.40
537
2884
518
2615
2.56
58.33
2.1
1.5
2.13
2.39
g/l
2.52
378
1596
274
991
3.20
58.17
9.1
4.2
120.20
87.52
ng/l
4.11
240
871
80
108
7.80
56.41
3.5
2.5
1117.97
1242.91
e6/l
0.45
71
94
56
48
12.11
55.23
2.2
2.0
—
—
—
0
0
285
1097
3.01
54.01
8.5
4.6
0.78
0.98
%
0.92
176
323
336
1432
2.77
52.58
10.6
4.5
7.37
7.38
ph
1.96
225
851
273
1043
3.01
52.31
7.8
4.4
0.64
0.67
%
0.11
168
303
49
39
12.98
50.53
5.5
4.0
—
—
—
0
0
84
137
6.46
49.77
1.2
1.2
—
—
—
0
0
322
1386
2.72
49.09
10.8
4.5
1.26
1.85
mmol/l
2.30
280
1153
86
146
6.21
48.97
2.4
2.4
17.48
47.01
iu/ml
0.63
17
12
613
3549
2.30
48.72
7.7
4.4
—
—
—
0
0
553
3072
2.32
48.41
7.0
2.4
—
—
—
0
0
290
1197
2.80
47.85
3.3
2.4
0.21
0.21
g/l
0.15
273
1112
326
1440
2.65
47.00
10.8
4.4
5.75
5.82
kpa
0.62
317
1392
91
172
5.59
46.33
1.6
1.2
4.43
5.69
u/ml
0.26
53
81
850
5731
2.23
45.30
7.4
2.9
—
—
estimate
—
0
0
48
44
11.26
45.26
1.1
1.2
687.50
900.00
titre
—
16
10
163
495
3.60
45.24
1.4
1.5
1.48
11.97
iu/ml
—
5
16
64
86
7.75
45.24
3.9
2.6
157.41
212.03
e6/l
1.51
54
73
161
487
3.61
44.94
2.8
1.8
17.36
7.85
iu/ml
0.94
42
117
671
4143
2.19
44.33
6.3
3.6
41.47
98.01
e6/l
1.85
551
3224
51
54
9.76
43.50
1.2
1.1
—
—
—
0
0
819
5508
2.18
43.02
27.0
11.7
0.08
0.00
e9/l
0.64
682
4488
61
84
7.55
42.20
3.9
2.6
593.04
551.55
e6/l
0.18
50
67
255
1048
2.75
42.01
8.9
4.7
0.08
0.11
%
0.46
145
273
730
4731
2.14
41.76
7.7
4.2
88.55
115.13
e6/l
0.44
561
3372
247
1005
2.77
41.45
1.7
1.4
—
—
—
0
0
595
3573
2.16
41.43
6.1
3.5
0.54
0.45
e6/l
0.31
468
2677
44
41
11.05
41.01
3.3
2.7
0.64
0.61
mmol/l
1.16
44
41
279
1223
2.60
40.29
16.8
9.8
—
—
—
0
0
1156
9076
2.58
40.19
19.3
8.1
83.15
81.24
u/l
0.75
1127
8601
69
117
6.15
39.28
3.0
2.2
—
—
—
0
0
140
422
3.58
39.15
1.5
1.2
—
—
—
0
0
602
3696
2.10
38.91
14.4
6.3
—
—
—
0
0
250
1061
2.65
38.43
9.0
4.9
0.06
0.18
%
1.30
136
252
52
67
8.02
38.04
3.1
2.5
1311.96
1203.39
u/ml
0.10
52
67
818
5654
2.08
38.02
29.5
15.7
1.40
1.27
inr
6.75
719
4724
122
346
3.77
37.31
1.4
1.2
96.25
82.29
titre
0.22
16
35
90
206
4.60
36.66
1.1
1.1
—
—
—
0
0
976
7257
2.14
36.62
10.8
5.6
6.80
6.68
mmol/l
0.86
932
6864
91
211
4.54
36.48
1.1
1.1
—
—
—
0
0
389
2074
2.21
35.61
5.2
3.3
2.47
2.38
e6/l
0.07
224
1080
473
2726
2.11
35.43
4.5
1.8
2.37
1.37
mg/l
1.80
394
2119
491
2897
2.07
34.32
4.8
2.8
4.67
5.81
e6/l
0.96
452
2638
784
5480
1.98
33.61
3.7
2.5
74.45
77.05
nmol/l
1.87
730
4942
63
114
5.74
33.53
1.8
2.4
—
—
—
0
0
442
2526
2.10
33.52
5.4
3.1
504.85
534.54
mosm/kgh2o
2.45
401
2225
592
3761
2.00
33.46
4.9
3.3
1943.36
1448.21
ng/l
1.81
518
3250
348
1833
2.20
32.44
2.5
2.1
—
—
—
0
0
263
1234
2.39
32.25
8.8
4.0
4.99
4.57
kpa
1.58
257
1194
399
2222
2.11
32.20
4.9
3.2
1.21
1.18
e6/l
0.04
237
1230
63
125
5.23
30.34
6.4
4.2
—
—
—
0
0
609
4052
1.89
28.77
5.9
3.3
37.70
33.13
u/l
1.08
590
3827
48
78
6.34
28.47
3.0
2.9
32.08
39.35
%
1.33
23
43
78
198
4.11
27.77
2.0
1.6
—
—
—
0
0
78
198
4.11
27.77
2.0
1.6
—
—
—
0
0
78
198
4.11
27.77
2.0
1.6
—
—
—
0
0
78
198
4.11
27.77
2.0
1.6
—
—
—
0
0
627
4278
1.84
26.79
4.7
3.4
2.33
2.35
mmol/l
3.63
576
3883
31
33
9.58
26.25
1.1
1.1
—
—
—
0
0
38
53
7.34
25.94
2.0
1.7
—
—
—
0
0
284
1499
2.12
25.70
2.0
1.7
—
—
—
0
0
243
1213
2.21
25.30
2.7
2.2
360.75
376.81
nmol/l
0.63
229
1126
43
71
6.22
25.10
1.4
1.7
—
—
—
0
0
45
78
5.93
25.03
2.2
1.6
15.27
13.37
umol/l
0.54
45
71
441
2739
1.89
25.00
10.1
4.5
—
—
—
0
0
30
33
9.27
24.79
1.9
1.8
39.43
28.82
%
1.67
30
33
30
33
9.27
24.79
1.0
1.0
—
—
—
0
0
566
3833
1.80
24.05
3.9
2.6
64.01
83.16
u/l
0.44
550
3563
29
32
9.23
23.90
1.1
1.2
—
—
—
0
0
73
197
3.85
23.89
2.3
1.7
0.79
0.85
g/l
0.12
58
159
51
104
5.05
23.81
1.2
1.1
95.00
168.50
titre
0.57
12
20
278
1499
2.07
23.59
11.3
8.9
7.42
7.42
ph
0.57
162
842
48
94
5.25
23.45
1.2
1.1
—
—
—
0
0
277
1501
2.05
23.15
11.4
8.9
4.97
5.10
kpa
1.28
267
1447
277
1502
2.05
23.11
11.4
8.9
12.14
12.12
kpa
0.02
265
1449
232
1180
2.16
22.90
3.8
2.4
39.42
79.01
u/l
0.47
208
989
273
1485
2.04
22.53
11.4
8.9
0.75
0.97
mmol/l
0.40
223
1224
97
329
3.09
22.27
1.3
1.2
4.87
2.37
u/ml
—
8
31
993
8018
1.82
22.25
7.1
4.8
596.89
2675.76
e6/l
1.44
18
120
33
17
19.85
22.19
9.0
9.8
6.57
5.17
mmol/l
0.84
33
17
96
329
3.06
21.65
1.4
1.2
3.72
7.77
u/ml
0.52
17
51
1061
8781
1.86
21.47
6.9
4.3
18.71
12.23
mm/h
17.56
1008
8187
98
344
2.99
21.19
1.3
1.2
59.87
11.71
u/ml
—
7
16
269
1493
1.99
20.84
4.3
3.1
4.28
5.19
e9/l
1.17
241
1302
44
89
5.07
20.74
1.2
1.1
—
—
—
0
0
85
284
3.12
20.02
5.4
3.5
0.85
0.82
nmol/l
0.16
38
239
30
43
7.11
19.98
3.8
3.5
0.17
0.36
e9/l
0.97
17
21
43
89
4.95
19.75
1.1
1.0
—
—
—
0
0
245
1350
1.99
19.26
12.2
9.3
95.75
95.60
%
0.18
233
1312
194
982
2.13
19.20
7.1
4.7
5.07
5.13
kpa
0.41
186
949
112
447
2.64
19.02
1.4
1.2
0.86
1.22
u/ml
—
5
26
79
262
3.14
18.84
1.3
1.2
40.00
45.46
u/ml
0.10
11
25
190
964
2.12
18.67
7.2
4.7
7.41
7.41
ph
0.21
165
806
385
2472
1.77
18.64
3.5
3.0
2.44
2.45
mmol/l
1.13
343
2215
228
1245
1.99
18.33
12.5
9.7
108.00
120.50
g/l
13.93
223
1220
170
832
2.19
18.30
8.5
3.9
114.75
128.50
g/l
8.54
165
814
826
6514
1.66
18.20
6.3
4.0
26.16
4.58
estimate
0.94
195
1430
819
6447
1.65
18.15
6.3
4.0
0.01
0.00
estimate
0.41
190
1401
829
6550
1.65
18.07
6.3
4.0
0.03
0.23
estimate
0.43
180
1337
53
140
3.90
17.89
2.8
2.6
0.93
1.12
g/24h
0.34
37
80
113
470
2.53
17.63
5.2
4.1
563.49
417.76
mg/l
0.38
69
222
689
5226
1.63
17.45
5.5
3.5
6.22
6.24
ph
0.14
346
2938
121
524
2.43
17.31
3.1
1.9
4.76
1.95
ug/l
0.60
110
465
369
2404
1.73
16.70
5.5
4.1
221.60
385.80
ng/l
1.37
305
1889
90
348
2.70
16.27
3.9
3.3
4.20
1.88
index
1.01
45
189
46
118
4.00
16.18
1.6
1.3
—
—
—
0
0
268
1608
1.82
16.02
1.4
1.3
—
—
—
0
0
52
147
3.64
15.95
1.2
1.2
—
—
—
0
0
523
3779
1.61
15.66
2.7
2.2
181.16
226.42
u/l
0.44
499
3582
45
117
3.94
15.55
1.6
1.3
0.41
0.41
g/l
0.01
30
88
45
117
3.94
15.55
1.6
1.3
2.34
2.65
g/l
0.44
34
88
45
117
3.94
15.55
1.6
1.3
7.57
6.99
g/l
0.17
33
89
147
725
2.15
15.45
7.7
3.4
1.34
1.19
%
1.13
147
720
54
160
3.47
15.45
1.2
1.2
—
—
—
0
0
25
39
6.51
15.40
1.4
1.1
—
—
—
0
0
530
3875
1.59
14.93
4.2
3.3
—
—
—
0
0
181
989
1.95
14.36
4.6
3.1
315.82
218.45
ng/l
1.61
166
916
488
3542
1.58
13.96
1.7
1.5
—
—
—
0
0
146
749
2.06
13.81
14.1
12.1
14.27
15.82
%
8.88
141
722
181
1002
1.93
13.80
2.3
2.5
11.24
7.31
ug/l
0.68
162
888
65
233
2.88
13.57
1.1
1.1
14.90
19.15
au/ml
—
5
56
39
101
3.94
13.57
1.2
1.1
—
—
—
0
0
521
3866
1.55
13.39
5.4
3.5
144.91
51.95
mg/l
1.88
400
2527
561
4238
1.54
13.26
5.8
3.5
6.92
7.60
mmol/l
3.38
500
3598
603
4629
1.53
13.23
5.6
4.0
45.75
74.94
ng/l
0.73
470
3329
48
146
3.37
13.21
7.5
5.7
10.33
11.07
%
0.66
48
146
95
417
2.37
13.19
1.7
1.7
46.12
9.50
u/ml
2.10
24
96
137
704
2.05
12.89
7.9
5.0
—
—
—
0
0
474
3469
1.55
12.84
5.0
3.2
0.50
0.03
—
8
78
32
75
4.34
12.69
1.1
1.0
—
—
—
0
0
523
3953
1.52
12.02
6.5
4.2
21.37
9.02
mg/mmol
3.48
393
2504
23
43
5.42
11.84
2.2
1.7
42.79
39.85
g/l
1.92
23
43
116
579
2.09
11.79
2.8
2.4
—
—
—
0
0
70
285
2.53
11.45
5.7
3.1
57.60
58.57
%
0.20
70
285
915
7830
1.49
10.88
5.3
3.3
51.99
48.24
u/l
0.71
877
7367
1259
11603
1.86
10.88
40.0
16.5
21.10
24.89
mg/l
6.38
1145
9615
86
394
2.26
10.84
1.2
1.4
335.32
244.61
miu/ml
0.76
26
187
34
95
3.64
10.67
1.7
1.5
—
—
—
0
0
113
585
2.01
10.41
7.3
5.3
24.18
24.65
mmol/l
0.96
107
552
579
4603
1.44
9.74
2.6
2.2
—
—
—
0
0
208
1326
1.67
9.72
1.7
1.8
—
—
—
0
0
22
30
7.43
9.71
1.3
1.2
28.14
27.47
s
0.17
22
30
198
1249
1.68
9.63
3.7
4.3
7.41
23.12
ug/l
1.27
165
1027
175
1069
1.73
9.57
4.3
2.5
0.28
0.53
e6/l
1.40
170
1022
354
2578
1.50
9.27
2.0
1.8
459.16
29118489.85
pmol/l
2.38
292
2143
303
2137
1.53
9.23
1.4
1.3
40.00
29.43
iu/ml
0.66
86
646
12
5
24.17
8.91
1.1
1.0
—
—
—
0
0
67
303
2.27
8.75
2.6
2.3
12.17
12.27
mg/l
0.03
62
284
62
273
2.33
8.61
5.9
4.0
—
—
—
0
0
18
24
7.58
8.16
1.3
1.3
—
—
—
0
0
221
1491
1.57
8.14
1.8
1.5
—
—
—
0
0
55
237
2.37
8.04
6.9
3.1
10.55
8.96
pmol/l
0.60
55
237
113
640
1.83
7.99
1.3
1.3
—
—
—
0
0
57
252
2.32
7.87
4.1
2.6
15.15
16.14
%
1.28
57
246
133
796
1.74
7.81
10.4
7.2
24.09
24.45
mmol/l
0.47
128
764
36
129
2.84
7.62
1.2
1.1
—
—
—
0
0
178
1160
1.61
7.57
2.7
2.1
0.00
0.01
estimate
0.50
42
257
277
2004
1.48
7.31
1.3
1.3
26.45
11.44
u/ml
0.34
97
751
7
0
+∞
7.30
4.4
0.0
—
—
—
0
0
96
539
1.84
7.00
8.8
6.0
0.89
0.88
%
0.08
91
512
198
1348
1.55
6.97
1.5
1.3
—
—
—
0
0
17
27
6.36
6.94
3.1
1.5
—
—
—
0
0
1249
11736
1.60
6.85
44.6
19.9
139.14
139.60
mmol/l
8.11
1232
11507
17
40
4.29
6.76
2.5
1.7
—
—
—
0
0
26
83
3.17
6.73
6.2
3.6
1.12
0.90
index
0.58
26
83
29
99
2.97
6.72
1.2
1.1
112.31
107.63
pmol/l
0.13
29
99
17
29
5.92
6.61
2.8
1.0
15.82
17.78
umol/l
0.87
17
24
34
128
2.70
6.60
1.1
1.1
—
—
—
0
0
91
512
1.83
6.60
2.0
1.7
0.30
0.32
mg/l
0.10
21
245
72
375
1.97
6.59
9.2
7.4
1.26
1.29
mmol/l
0.12
58
330
101
589
1.77
6.51
8.6
5.7
2.08
1.56
%
4.67
96
561
36
141
2.59
6.48
1.6
1.4
40493.90
116373.63
e6/l
0.66
21
78
1248
11756
1.57
6.40
46.7
20.0
4.01
3.98
mmol/l
3.19
1227
11500
69
360
1.96
6.30
1.2
1.2
—
—
—
0
0
39
163
2.43
6.15
1.8
1.7
39.16
30.69
ng/l
0.30
39
163
376
2956
1.37
6.11
1.4
1.3
1.69
1.86
u/ml
0.07
81
786
51
242
2.15
6.01
7.9
4.9
3.14
2.67
mmol/l
0.48
35
163
39
165
2.40
6.00
2.6
2.7
—
—
—
0
0
33
130
2.58
5.89
6.3
3.5
13.96
12.59
index
0.29
26
83
15
26
5.82
5.84
1.7
1.8
—
—
—
0
0
28
102
2.78
5.81
1.5
1.2
—
—
—
0
0
50
239
2.13
5.80
1.5
1.3
57.72
63.72
mmol/l
0.48
36
194
145
964
1.56
5.66
9.8
3.9
1.22
1.23
mmol/l
0.41
133
827
38
164
2.35
5.62
1.6
1.4
816.79
1694.15
e6/l
1.95
24
111
21
66
3.22
5.60
3.3
1.8
141.93
105.91
ng/l
0.71
21
66
113
712
1.64
5.52
3.5
3.5
4.19
4.59
pmol/l
3.53
101
633
213
1545
1.45
5.47
1.4
1.3
—
—
—
0
0
42
193
2.21
5.38
1.5
1.4
28.30
31.31
g/l
0.73
37
174
441
3610
1.32
5.37
6.2
4.0
0.01
0.01
estimate
0.20
167
1305
82
479
1.76
5.30
4.1
3.6
600.71
3213.71
u/ml
0.67
74
415
21
69
3.07
5.23
2.1
1.4
24.40
21.68
umol/l
0.14
21
62
58
306
1.93
5.18
3.1
2.2
121.16
129.38
g/l
1.24
44
248
64
349
1.87
5.17
1.3
1.2
—
—
—
0
0
17
50
3.43
5.03
1.9
1.3
—
—
—
0
0
39
179
2.21
5.03
2.4
2.8
—
—
—
0
0
1267
12079
1.52
4.98
25.9
12.0
25.96
25.93
u/l
0.02
1250
11732
53
275
1.96
4.97
3.4
2.5
117.68
105.47
ug/min
0.09
39
164
14
29
4.87
4.81
4.0
3.2
—
—
—
0
0
995
9164
1.30
4.58
5.0
4.3
14.86
14.84
pmol/l
0.10
920
8400
50
264
1.93
4.49
11.8
8.7
11.19
11.29
mmol/l
0.07
43
242
50
264
1.93
4.49
11.8
8.7
106.26
105.42
mmol/l
0.53
43
242
1274
12198
1.50
4.48
47.5
21.4
93.33
77.96
umol/l
11.00
1261
12056
10
15
6.71
4.47
2.2
3.7
—
—
—
0
0
37
176
2.13
4.41
2.4
2.7
15.63
9.26
umol/l
0.42
32
132
356
2896
1.31
4.41
5.6
4.0
1.05
1.02
kg/l
0.49
243
1958
153
1089
1.45
4.34
6.2
4.2
7.36
7.36
ph
0.05
123
788
32
145
2.24
4.29
1.6
1.6
—
—
—
0
0
212
1602
1.38
4.29
3.4
2.4
143.70
123.73
ug/g
0.47
175
1270
358
4309
0.77
4.22
3.7
3.1
—
—
—
0
0
49
263
1.89
4.21
2.7
1.7
1.21
0.87
nmol/l
2.20
39
221
11
21
5.27
4.14
2.0
1.3
—
—
—
0
0
63
372
1.73
3.99
1.5
1.5
266.80
285.50
ug/g
0.38
51
221
91
602
1.55
3.70
2.6
2.2
0.00
1.31
estimate
0.51
31
194
34
169
2.04
3.66
2.4
1.4
47.00
56.69
mu/l
0.20
28
151
14
45
3.13
3.65
1.5
1.5
—
—
—
0
0
558
4884
1.24
3.64
6.2
3.9
0.04
0.05
estimate
0.08
161
1166
92
613
1.54
3.63
6.4
3.8
1.02
1.02
ratio
0.60
84
568
48
270
1.81
3.61
1.6
1.4
1.24
1.27
mm
0.19
37
197
63
384
1.67
3.58
1.6
1.5
9.57
8.72
u/l
0.21
49
306
49
279
1.78
3.54
1.8
1.5
—
—
—
0
0
23
99
2.35
3.51
1.1
1.1
306.09
290.51
mg/l
0.36
23
87
34
172
2.00
3.50
1.2
1.2
—
—
—
0
0
8
13
6.18
3.50
1.5
1.6
—
—
—
0
0
12
31
3.89
3.49
1.4
1.4
8.21
8.61
mmol/l
0.12
12
31
28
132
2.14
3.47
1.4
1.7
67.85
60.55
%
0.55
22
95
1138
10797
1.29
3.39
6.3
5.3
2.00
1.92
mu/l
1.25
1078
9996
48
276
1.77
3.37
1.6
1.4
—
—
—
0
0
56
337
1.69
3.36
1.9
1.8
—
—
—
0
0
13
43
3.04
3.25
2.5
3.3
—
—
—
0
0
7
11
6.39
3.18
3.4
3.3
—
—
—
0
0
9
20
4.52
3.11
2.1
1.6
1.36
1.24
umol/l
—
9
14
62
952
0.64
3.10
1.3
1.3
—
—
—
0
0
10
25
4.02
3.08
1.6
2.1
—
—
—
0
0
28
139
2.04
3.07
1.6
1.4
—
—
—
0
0
7
12
5.86
3.02
1.1
1.1
—
—
—
0
0
22
100
2.22
3.00
3.4
3.3
157.49
27.63
mg/l
1.23
17
76
50
302
1.68
2.99
1.4
1.6
767.63
534.14
e6/l
0.16
35
232
49
299
1.66
2.83
1.3
1.6
3.65
40.35
e6/l
1.07
31
222
13
47
2.78
2.82
2.5
3.1
—
—
—
0
0
1234
11900
1.32
2.77
34.7
14.8
—
—
—
0
0
460
4037
1.21
2.75
5.0
3.7
—
0.77
—
0
13
5
6
8.36
2.75
1.0
1.8
—
—
—
0
0
30
160
1.89
2.72
2.3
1.8
—
—
—
0
0
14
54
2.61
2.70
1.4
1.3
171.29
175.66
mmol/24h
0.04
14
54
29
154
1.90
2.67
1.3
1.4
375.55
321.39
pmol/l
0.46
22
135
24
119
2.03
2.67
1.3
1.1
—
—
—
0
0
48
297
1.64
2.65
1.2
1.5
4.11
3.69
mmol/l
1.35
42
282
23
113
2.05
2.62
1.8
2.4
—
—
—
0
0
112
835
1.37
2.52
1.6
1.3
159.67
234.57
u/ml
0.84
95
775
405
3540
1.20
2.49
6.4
3.4
0.02
0.04
estimate
0.36
150
1125
56
366
1.55
2.49
1.7
1.5
62.62
63.32
ug/l
0.03
45
312
84
1156
0.71
2.44
1.7
1.9
3.48
3.52
ratio
0.11
66
897
30
168
1.80
2.37
1.2
1.4
5.37
3.35
ug/l
1.01
24
149
8
22
3.65
2.36
6.4
2.7
0.88
3.27
%
—
8
22
7
17
4.13
2.36
1.0
1.3
—
—
—
0
0
31
176
1.78
2.35
1.7
1.4
0.28
0.38
nmol/l
0.73
23
140
8
23
3.49
2.27
1.0
1.0
—
—
—
0
0
43
271
1.61
2.25
1.3
1.6
—
—
—
0
0
39
240
1.64
2.24
1.3
1.1
—
—
—
0
0
39
241
1.64
2.21
1.3
1.1
—
—
—
0
0
26
143
1.83
2.19
1.3
1.2
—
—
—
0
0
18
87
2.08
2.17
1.2
1.3
—
—
—
0
0
68
479
1.44
2.15
3.1
2.7
—
—
—
0
0
9
30
3.01
2.15
1.2
1.2
—
—
—
0
0
9
31
2.92
2.07
1.7
3.2
4.11
5.87
ug/l
—
9
31
50
334
1.52
2.06
1.2
1.6
454.53
489.78
mg/l
0.37
45
316
102
776
1.34
2.06
1.5
1.2
—
—
—
0
0
7
20
3.51
2.05
1.6
1.3
—
—
—
0
0
129
1022
1.29
1.96
7.9
3.9
—
—
—
0
0
5
11
4.56
1.94
6.0
4.4
0.24
0.18
%
—
5
11
5
11
4.56
1.94
1.2
1.0
—
—
—
0
0
73
534
1.39
1.90
1.5
1.5
23.99
23.62
iu/l
0.03
60
449
20
107
1.88
1.86
3.3
5.9
525.80
58.01
u/ml
—
5
37
25
146
1.73
1.78
1.4
1.5
—
—
—
0
0
40
264
1.53
1.77
6.1
3.3
7.55
7.68
mmol/l
0.13
40
259
1130
10911
1.19
1.75
5.6
5.1
6.09
5.93
mmol/l
2.18
1046
9962
7
24
2.93
1.72
1.3
1.1
—
—
—
0
0
5
13
3.86
1.71
3.0
3.5
—
—
—
0
0
26
156
1.68
1.69
1.2
1.3
278.20
279.14
mosm/kgh2o
0.07
20
114
72
537
1.36
1.69
1.2
1.3
—
—
—
0
0
61
446
1.38
1.63
1.8
1.6
283.58
285.75
mu/l
0.03
56
405
18
98
1.85
1.62
1.3
1.3
—
—
—
0
0
29
182
1.61
1.61
1.2
1.2
—
—
—
0
0
7
26
2.70
1.58
2.3
2.0
—
—
—
0
0
13
64
2.04
1.54
1.0
1.1
0.23
1.35
u/ml
—
8
26
127
1038
1.25
1.54
1.2
1.2
—
—
—
0
0
11
51
2.17
1.50
1.0
1.1
176.89
227.95
iu/ml
0.30
11
51
13
65
2.01
1.49
2.8
2.0
27.54
28.50
umol/l
0.08
13
60
66
864
0.75
1.47
1.3
1.7
3.59
3.44
mmol/l
0.38
46
613
9
38
2.38
1.45
2.8
1.8
—
—
—
0
0
15
80
1.88
1.45
1.0
1.3
0.68
4.01
u/ml
—
7
36
11
52
2.12
1.44
1.7
3.6
67.17
96.90
umol/l
—
6
30
13
66
1.98
1.43
1.2
1.2
133.00
148.51
nmol/l
0.54
13
66
6
23
2.62
1.37
1.0
1.1
—
—
—
0
0
142
1192
1.21
1.36
1.8
1.5
—
—
—
0
0
5
17
2.95
1.36
2.2
3.1
45.60
44.18
%
—
5
17
5
17
2.95
1.36
4.4
6.2
12.60
8.12
%
—
5
17
114
937
1.24
1.34
3.6
2.7
5.98
6.11
ph
0.83
84
635
8
36
2.23
1.24
1.0
1.7
18.00
15.19
pmol/l
—
8
29
38
525
0.72
1.24
1.1
1.1
—
—
—
0
0
1283
12607
1.22
1.22
63.7
25.0
121.94
134.46
g/l
89.30
1274
12468
5
19
2.64
1.21
1.2
1.4
63.60
67.63
ug/l
—
5
19
1282
12598
1.21
1.20
63.0
24.9
240.94
248.96
e9/l
2.65
1262
12344
23
148
1.56
1.20
1.3
2.0
—
—
—
0
0
43
315
1.38
1.19
1.6
1.6
22630.55
13804.07
e6/l
0.53
31
229
1282
12600
1.21
1.19
62.7
24.8
91.11
90.90
fl
0.37
1272
12464
11
57
1.94
1.17
1.1
1.2
—
75.57
%
—
0
7
1282
12603
1.21
1.16
64.5
25.5
36.78
40.14
%
70.18
1272
12459
1282
12603
1.21
1.16
62.7
24.8
30.18
30.27
pg
0.44
1272
12465
1282
12603
1.21
1.16
62.8
24.8
4.14
4.47
e12/l
40.94
1257
12311
1282
12605
1.21
1.15
62.9
24.9
7.64
6.82
e9/l
3.24
1257
12307
38
517
0.73
1.14
1.8
1.6
—
—
—
0
0
11
195
0.56
1.11
1.6
1.8
—
—
—
0
0
16
96
1.67
1.10
1.0
1.6
0.88
1.19
promille
0.37
11
79
44
330
1.34
1.08
2.1
2.0
175.63
21.48
iu/l
0.41
18
133
15
89
1.69
1.07
2.1
2.6
7.79
8.40
mmol/l
0.36
15
89
11
59
1.87
1.07
3.9
2.6
1963.64
1940.88
ml
0.02
11
51
10
52
1.93
1.06
1.7
1.8
—
—
—
0
0
16
98
1.64
1.03
2.3
2.3
7.99
6.86
mmol/l
—
10
66
43
324
1.34
1.03
6.2
3.1
1.60
1.55
mmol/l
0.12
43
318
9
47
1.92
1.02
1.2
1.0
—
—
—
0
0
16
99
1.62
1.00
2.9
2.5
17.61
29.39
mg/l
1.47
11
69
7
35
2.00
1.00
1.0
1.2
—
8.50
%
—
0
6
5
23
2.18
0.98
1.4
1.0
—
—
—
0
0
5
23
2.18
0.98
1.4
1.0
—
—
—
0
0
5
23
2.18
0.98
1.4
1.0
—
—
—
0
0
14
84
1.67
0.98
1.0
1.1
0.76
0.81
u/ml
—
7
44
10
54
1.86
0.96
1.1
1.0
1162.00
1559.09
miu/ml
—
10
54
207
2298
0.88
0.91
3.0
3.3
0.84
0.77
ug/l
0.36
150
1490
33
245
1.36
0.89
1.2
1.2
—
—
—
0
0
28
381
0.73
0.89
1.0
1.1
1.52
1.53
g/l
0.02
28
381
14
87
1.62
0.87
1.0
1.0
—
—
—
0
0
6
32
1.88
0.82
1.2
1.5
0.03
1.15
u/ml
—
6
32
93
795
1.18
0.80
2.4
2.5
40.26
16.65
au/ml
—
7
67
10
59
1.70
0.76
1.4
1.1
—
—
—
0
0
39
306
1.28
0.75
7.9
4.9
—
—
—
0
0
13
83
1.57
0.75
2.3
2.9
15.05
16.25
%
0.46
13
83
5
24
2.09
0.74
1.0
1.0
3.93
5.37
mg/g
—
5
24
36
281
1.29
0.73
1.4
1.1
3.26
2.64
u/ml
0.08
24
166
5
25
2.00
0.72
1.0
1.0
—
—
—
0
0
7
40
1.75
0.71
1.3
3.0
1.53
3.09
mmol/l
—
7
34
85
732
1.17
0.70
1.3
1.3
58.33
43.39
au/ml
—
9
50
14
93
1.51
0.69
1.3
1.4
37.92
28.62
%
—
9
66
31
239
1.30
0.69
1.1
1.1
0.82
1.22
u/ml
0.27
16
128
95
829
1.16
0.67
1.3
1.2
200.59
133.11
u/ml
0.43
28
320
121
1357
0.88
0.66
1.5
1.6
—
—
—
0
0
12
78
1.54
0.65
1.1
1.2
0.53
0.54
ratio
—
6
44
5
29
1.73
0.64
3.4
8.8
5.26
5.23
kpa
—
5
29
18
129
1.40
0.63
2.7
2.0
—
—
—
0
0
67
572
1.18
0.62
2.8
2.0
—
—
—
0
0
5
30
1.67
0.61
1.0
1.2
139.20
138.65
mmol/l
—
5
23
8
52
1.54
0.59
1.1
1.1
—
18.57
—
0
7
31
246
1.27
0.58
1.1
1.1
8.89
4.94
u/ml
0.48
17
149
73
633
1.16
0.58
1.6
1.6
1099.37
976.48
mu/l
0.49
59
543
18
240
0.75
0.55
1.1
1.2
—
—
—
0
0
7
50
1.40
0.45
1.0
1.1
—
—
—
0
0
12
86
1.40
0.44
1.3
1.5
89.17
82.41
umol/l
0.48
12
86
1081
10653
1.06
0.44
7.9
6.5
37.42
39.27
mmol/mol
6.59
1001
9949
56
490
1.15
0.43
2.7
2.3
9942.19
5855.20
u/l
0.44
19
214
0
15
0.00
0.41
0.0
1.0
—
17.29
—
0
7
0
16
0.00
0.41
0.0
1.1
—
0.02
—
0
16
8
59
1.36
0.41
1.6
1.9
1.70
4.41
nmol/l
—
8
48
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
10
71
1.41
0.39
3.5
2.2
15.69
3.46
ug/l
—
10
66
5
37
1.35
0.37
11.2
2.6
9.54
10.43
mg/l
—
5
32
18
145
1.24
0.33
1.6
1.3
0.16
0.18
nmol/l
0.36
13
111
6
45
1.33
0.33
2.3
1.7
0.37
0.48
e9/l
—
6
45
48
426
1.13
0.32
3.1
2.0
—
—
—
0
0
26
303
0.86
0.29
1.0
1.1
—
—
—
0
0
15
121
1.24
0.28
2.1
2.4
—
—
—
0
0
1068
10568
1.04
0.28
4.9
4.2
1.33
1.27
mmol/l
1.64
978
9678
8
66
1.21
0.26
3.4
2.7
—
—
—
0
0
8
67
1.20
0.26
1.1
1.2
—
—
—
0
0
31
274
1.13
0.24
1.4
1.3
—
—
—
0
0
138
1313
1.06
0.23
2.0
1.7
—
—
—
0
0
26
229
1.14
0.21
4.9
2.6
—
—
—
0
0
36
398
0.90
0.21
1.6
1.2
0.88
0.90
g/l
0.26
36
398
0
13
0.00
0.21
0.0
1.0
—
17.04
—
0
13
0
14
0.00
0.20
0.0
1.0
—
6.33
—
0
14
1122
11140
1.04
0.20
5.7
5.0
4.29
4.56
mmol/l
15.30
1051
10375
41
380
1.08
0.15
6.7
2.6
—
—
—
0
0
51
540
0.94
0.13
3.2
1.8
—
—
—
0
0
1125
11305
0.98
0.13
6.4
5.7
2.45
2.65
mmol/l
12.20
1051
10483
23
251
0.91
0.12
7.6
3.7
16.56
28.52
mg/l
2.35
16
176
16
143
1.12
0.11
1.0
1.1
—
—
—
0
0
52
547
0.95
0.11
3.2
1.9
—
—
—
0
0
33
351
0.94
0.10
8.2
11.6
—
—
—
0
0
52
544
0.95
0.09
3.1
1.9
—
—
—
0
0
106
1030
1.03
0.09
2.4
2.3
10.03
13.06
nmol/l
3.18
91
923
6
57
1.05
0.08
1.0
1.0
8.48
7.27
kpa
—
6
41
6
57
1.05
0.08
1.0
1.0
—
—
—
0
0
52
539
0.96
0.07
3.1
1.9
—
—
—
0
0
16
173
0.92
0.06
1.0
1.1
1.24
0.36
u/ml
—
7
71
40
387
1.03
0.04
1.8
1.8
41.90
40.58
nmol/l
0.12
40
370
383
3806
1.01
0.04
4.8
5.6
2.26
2.59
ug/l
0.56
348
3426
474
4758
0.99
0.02
2.2
1.9
1.41
1.34
mmol/l
1.06
408
4030
15
142
1.06
0.02
1.8
1.3
—
—
nmol/l
—
0
0
44
447
0.98
0.01
1.2
1.1
—
—
—
0
0
18
182
0.99
0.00
1.1
1.1
1.79
8.28
u/ml
—
9
84
20
198
1.01
0.00
1.1
1.1
3.66
7.07
u/ml
0.81
12
105
24
238
1.01
0.00
1.0
1.1
0.17
1.48
u/ml
2.77
13
138
1108
11078
1.00
0.00
5.6
4.9
1.37
1.45
mmol/l
7.54
1028
10243
51
507
1.01
0.00
3.1
1.9
—
—
—
0
0
6
65
0.92
0.00
1.0
1.0
19.17
19.41
mmol/l
—
6
59
0
7
0.00
0.00
0.0
4.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
0.03
—
0
7
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
358.29
—
0
7
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
73
0.96
-0.00
3.0
1.2
34.21
5.92
ug/l
—
7
63
7
73
0.96
-0.00
1.6
1.2
158.76
164.57
pmol/l
—
7
73
5
56
0.89
-0.00
1.0
1.0
2.68
3.38
kpa
—
5
40
5
57
0.88
-0.00
1.2
1.3
7.40
9.56
mm/h
—
5
57

Mortality – FinRegistry

Association

Association between endpoint D3_HAEMOLYTICANAEMIA and mortality.

Females

Parameter HR [95% CI] p-value
D3_HAEMOLYTICANAEMIA 2.473 [2.14, 2.85] < 0.001
Birth year 0.991 [0.98, 1.0] 0.033

During the follow-up period (1.1.1998 — 31.12.2019), 1256 out of 4383 females with D3_HAEMOLYTICANAEMIA died.

Males

Parameter HR [95% CI] p-value
D3_HAEMOLYTICANAEMIA 2.749 [2.33, 3.24] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 1102 out of 3793 males with D3_HAEMOLYTICANAEMIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_HAEMOLYTICANAEMIA.

N-year risk Females Males
1 0.245% 0.505%
5 1.307% 3.3%
10 3.425% 7.845%
15 6.329% 14.152%
20 10.539% 23.642%

Relationships between endpoints

Index endpoint: D3_HAEMOLYTICANAEMIA – Haemolytic anaemias

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data