Acquired haemolytic anaemia

D3_ACQHAEMOLYTICANAEMIA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D59
  • Cause of death: ICD-10 D59

2 out of 7 registries used, show all original rules.

991

4. Check minimum number of events

None

991

5. Include endpoints

1058

6. Filter based on genotype QC (FinnGen only)

907

Control definitions (FinnGen only)

Control exclude
D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D55-D59
Name in latin
Anaemia haemolytica acquisita

Similar endpoints

List of similar endpoints to Acquired haemolytic anaemia based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7041 3819 3130
Only index persons 4923 2698 2225
Unadjusted period prevalence (%)
Whole population 0.10 0.11 0.09
Only index persons 0.09 0.10 0.08
Median age at first event (years)
Whole population 65.04 66.51 63.16
Only index persons 61.86 62.50 61.08

-FinnGen-

Key figures

All Female Male
Number of individuals 907 466 441
Unadjusted period prevalence (%) 0.18 0.17 0.20
Median age at first event (years) 62.69 58.15 67.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
942
Matched controls
9420
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
312.4
282
*
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
307.7
442
*
XW000
NOMESCO Finland
Bone marrow biopsy
16.9
251.6
231
178
D64.9
ICD-10 Finland
Anaemia, unspecified
8.9
227.1
378
660
WW500
NOMESCO Finland
Blood transfusion
10.8
145.0
171
189
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.9
103.9
298
812
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
23.9
97.7
71
32
TK800
NOMESCO Finland
Hemodialysis
13.3
93.8
92
76
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
27.6
90.2
62
24
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
12.0
88.0
92
84
L04AA06
ATC
mycophenolic acid; systemic
13.7
85.6
82
65
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
18.4
82.4
67
39
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.9
81.2
136
224
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
25.2
80.3
57
24
ZX120
NOMESCO Finland
Intravenous
4.9
76.7
198
486
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
75.0
71
*
B03XA02
ATC
darbepoetin alfa; parenteral
10.1
70.8
83
89
127
Kela drug reimbursment
Transplant complication
14.5
70.5
65
48
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
14.2
68.8
64
48
Z94.0
ICD-10 Finland
Kidney transplant status
18.8
68.5
55
31
H02AB06
ATC
prednisolone; systemic
3.3
65.6
609
3388
D59.8
ICD-10 Finland
Other acquired haemolytic anaemias
+∞
65.4
62
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
9.3
63.2
79
92
D59.3
ICD-10 Finland
Haemolytic-uraemic syndrome
+∞
63.2
60
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
23.6
61.9
45
20
Z49.1
ICD-10 Finland
Extracorporeal dialysis
14.4
61.8
57
42
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.0
59.2
472
2370
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
10.1
58.4
68
72
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.9
55.4
134
308
D64.8
ICD-10 Finland
Other specified anaemias
9.5
55.2
67
75
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.9
54.0
607
3601
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
8.6
54.0
71
88
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
53.8
402
1925
B03XA01
ATC
erythropoietin; parenteral
14.8
53.1
48
34
N08.2*D59.3
ICD-10 Finland
Glomerular disorders in haemolytic-uraemic syndrome
+∞
52.6
50
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
7.6
51.5
76
108
L04AD02
ATC
tacrolimus; systemic
15.7
51.4
45
30
L04AD01
ATC
ciclosporin; systemic
10.6
49.1
55
55
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.9
48.8
117
266
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
14.5
47.0
43
31
A12AA04
ATC
calcium carbonate; oral
9.8
45.8
54
58
A11CC03
ATC
alfacalcidol; systemic
7.1
45.1
70
105
N18.0
ICD-10 Finland
End-stage renal disease
13.8
43.6
41
31
D59.0
ICD-10 Finland
Drug-induced autoimmune haemolytic anaemia
+∞
43.0
41
*
L04AX01
ATC
azathioprine; systemic
5.7
43.0
84
159
C03CA01
ATC
furosemide; systemic
2.5
41.3
429
2348
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.6
40.6
148
458
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
13.1
40.3
39
31
M04AA01
ATC
allopurinol; systemic
3.0
39.3
212
832
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
39.1
300
1414
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.4
36.7
148
487
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
36.4
248
1097
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
12.0
36.2
37
32
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
35.3
179
675
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
5.4
35.2
72
142
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.6
34.8
126
386
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.6
34.5
258
1192
JN4AD
NOMESCO Finland
Body CT examination
3.0
34.5
174
654
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.5
33.6
86
205
L04AA01
ATC
[U] ciclosporin
10.7
33.5
37
36
V03AE01
ATC
polystyrene sulfonate; oral
8.6
33.2
43
52
H02AB07
ATC
prednisone; oral
2.8
31.9
187
761
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.7
31.7
109
322
D70.89
ICD-10 Finland
Neutropenic splenomegaly
9.8
31.7
37
39
UJF32
NOMESCO Finland
Coloscopy
2.3
31.3
318
1679
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
29.0
338
1879
137
Kela drug reimbursment
Uraemia requiring dialysis
11.4
28.6
30
27
I35.0
ICD-10 Finland
Aortic (valve) stenosis
3.4
28.4
110
351
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
8.5
28.4
37
45
D59.5
ICD-10 Finland
Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
+∞
28.3
27
*
R50.9
ICD-10 Finland
Fever, unspecified
2.6
28.1
204
919
A02BC02
ATC
pantoprazole; systemic
2.3
27.1
696
5211
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.3
27.0
73
181
2839X
ICD-9 Finland
Acquired haemolytic anaemias, Acquired haemolytic anaemia, unspecified
+∞
26.2
25
*
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
8.7
25.9
33
39
B03BA03
ATC
hydroxocobalamin; parenteral
3.5
25.8
93
283
WW400
NOMESCO Finland
Plasmaferesis
133.6
24.7
26
*
B01AA03
ATC
warfarin; systemic
2.3
24.6
251
1308
L03AA02
ATC
filgrastim; parenteral
4.8
24.3
57
126
ZXD05
NOMESCO Finland
Urgent procedure
2.1
24.2
334
1958
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
7.6
23.9
34
46
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.1
23.7
51
105
JN4BD
NOMESCO Finland
Extensive body CT
2.7
23.4
141
577
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
25.4
23.2
32
13
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
19.1
23.2
35
19
2830A
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA PRIMARIA]
+∞
23.0
22
*
WW200
NOMESCO Finland
Immunization
5.1
23.0
49
100
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.2
21.5
89
295
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
8.1
21.4
29
37
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
6.5
21.1
35
56
1XC02, ,
NOMESCO Finland
18.4
21.0
32
18
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.5
20.9
75
227
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
22.1
20.9
30
14
D59.6
ICD-10 Finland
Haemoglobinuria due to haemolysis from other external causes
+∞
20.9
20
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
20.8
252
1394
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
8.9
20.7
26
30
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
6.7
20.1
32
49
N18.8
ICD-10 Finland
Other chronic renal failure
4.8
20.0
46
100
H02AB09
ATC
hydrocortisone; systemic
4.9
19.6
44
94
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.0
19.1
92
333
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
18.9
275
1617
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
6.7
18.8
30
46
6BA02, ,
NOMESCO Finland
71.4
18.8
21
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.6
18.7
63
183
B82
ICPC
Anaemia other/unspecified
3.9
18.7
56
150
TGC00
NOMESCO Finland
Bronchial lavation
4.2
18.3
50
125
V03AE02
ATC
sevelamer; oral
22.2
18.2
26
12
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.4
18.2
46
108
GD1AD
NOMESCO Finland
Thorax CT examination
2.9
18.2
89
325
Z3231
NOMESCO Finland
Registered nurse
1.9
18.0
296
1809
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.2
18.0
75
249
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
33.6
18.0
23
7
D59.2
ICD-10 Finland
Drug-induced nonautoimmune haemolytic anaemia
+∞
17.8
17
*
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
42.9
17.3
21
5
3AC01, ,
NOMESCO Finland
14.4
16.9
28
20
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.1
16.7
47
120
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
16.6
160
803
K83
ICPC
Heart valve disease NOS
7.1
16.6
25
36
I50.9
ICD-10 Finland
Heart failure, unspecified
2.1
16.6
191
1027
M31.1
ICD-10 Finland
Thrombotic microangiopathy
172.9
16.5
17
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
12.4
16.4
29
24
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.4
16.4
60
184
A10AC01
ATC
insulin (human); parenteral
2.6
16.3
100
410
JN6AD
NOMESCO Finland
CT of torso and neck
5.2
16.1
33
65
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
12.5
15.9
28
23
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
15.9
265
1618
UJF92
NOMESCO Finland
Capsular endoscopy
4.9
15.8
35
74
PJA10
NOMESCO Finland
Exploration of lymph nodes
6.1
15.7
27
45
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
26.8
15.6
21
8
H02AB04
ATC
methylprednisolone; systemic
2.2
15.6
157
800
WX872
NOMESCO Finland
Intensive care
3.0
15.4
69
239
D50.8
ICD-10 Finland
Other iron deficiency anaemias
6.0
15.3
27
46
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
15.3
138
674
I34.1
ICD-10 Finland
Mitral (valve) prolapse
4.0
15.2
44
115
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
4.2
15.1
41
102
Z2221
NOMESCO Finland
Medical doctor
1.8
15.1
273
1706
R4110
NOMESCO Finland
Physiotherapy
1.8
15.1
288
1830
A10AB05
ATC
insulin aspart; parenteral
2.6
15.0
94
390
B01AB05
ATC
enoxaparin; parenteral
1.8
14.8
326
2160
A41.9
ICD-10 Finland
Sepsis, unspecified
3.3
14.6
55
172
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
5.5
14.5
28
52
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
36.7
14.5
18
5
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
15.7
14.4
23
15
L01AA02
ATC
chlorambucil; oral
17.3
14.3
22
13
C07AB07
ATC
bisoprolol; oral
1.7
14.1
500
3763
ZX108
NOMESCO Finland
Inhalation
11.1
14.1
26
24
B01AB10
ATC
tinzaparin; parenteral
2.2
14.0
126
614
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.3
13.9
54
172
JN3AD
NOMESCO Finland
Abdominal CT examination
2.1
13.9
141
720
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
3.6
13.9
47
137
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
24.2
13.8
19
8
M05BA04
ATC
alendronic acid; oral
2.3
13.7
106
484
J01MA02
ATC
ciprofloxacin; systemic
1.7
13.7
376
2637
JMA10
NOMESCO Finland
Transabdominal total splenectomy
12.3
13.6
24
20
SPAT1255
SPAT
Intravenous administration of medicine
2.6
13.6
79
315
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
6.0
13.6
24
41
J01MA12
ATC
levofloxacin; systemic
1.9
13.6
195
1127
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
13.5
176
984
L01AA01
ATC
cyclophosphamide; systemic
16.5
13.5
21
13
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.1
13.5
56
186
J01MA14
ATC
moxifloxacin; systemic
2.3
13.4
104
476
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.6
13.3
45
131
SPAT1088
SPAT
Blood transfusion
15.3
13.1
21
14
J01FF01
ATC
clindamycin; systemic
1.8
13.1
264
1693
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
13.1
219
1328
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.3
12.9
109
516
UJF30
NOMESCO Finland
Ileoscopy through colon
2.2
12.9
113
543
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
12.9
135
697
R06.0
ICD-10 Finland
Dyspnoea
1.7
12.9
288
1902
196
Kela drug reimbursment
Paricalcitol and cinacalcet
14.3
12.8
21
15
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
15.7
12.7
20
13
122
Kela drug reimbursment
Aplastic anaemia
70.8
12.6
14
*
WX882
NOMESCO Finland
High dependency care
3.5
12.6
44
131
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
4.2
12.6
33
80
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
12.6
482
3662
28390
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria primaria
+∞
12.5
12
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.1
12.5
134
697
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
24.7
12.5
17
7
E87.5
ICD-10 Finland
Hyperkalaemia
4.1
12.5
34
85
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.0
12.4
55
190
B81
ICPC
Anaemia vit B12/folate deficiency
3.1
12.3
53
180
WX892
NOMESCO Finland
Monitored bed care
2.4
12.3
92
414
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.6
12.2
41
119
K92.1
ICD-10 Finland
Melaena
2.6
12.1
72
291
L01XX52
ATC
venetoclax; oral
21.6
12.0
17
8
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
2.9
11.9
58
211
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
47.3
11.9
14
*
ZXE00
NOMESCO Finland
One hour or less
1.6
11.7
368
2644
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.0
11.7
138
743
C90.0
ICD-10 Finland
Multiple myeloma
5.6
11.7
22
40
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
2.9
11.7
56
202
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
30.4
11.7
15
5
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
4.0
11.6
33
85
A04AA01
ATC
ondansetron; systemic, rectal
2.3
11.6
90
411
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
11.3
11.6
21
19
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.7
11.6
241
1553
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
11.6
125
652
J05AB11
ATC
valaciclovir; oral
1.9
11.5
152
851
28398
ICD-8 Finland
Acquired haemolytic anaemias, Aliae definitar
+∞
11.5
11
*
C09AA02
ATC
enalapril; systemic
1.8
11.5
203
1247
Z49.2
ICD-10 Finland
Other dialysis
10.7
11.3
21
20
B05DB
ATC
Hypertonic solutions
10.7
11.3
21
20
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.5
11.2
39
116
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.4
11.2
79
346
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
20.3
11.2
16
8
WX203
NOMESCO Finland
Infraclavicular plexus blockade
4.2
11.1
29
70
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
3.3
11.1
42
132
A07AA09
ATC
vancomycin; oral
5.0
10.8
23
47
TK810
NOMESCO Finland
Hemofiltration
13.1
10.7
18
14
D64
ICD-10 Finland
Other anaemias
60.7
10.6
12
*
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
11.4
10.6
19
17
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
10.6
379
2796
I50.0
ICD-10 Finland
Congestive heart failure
2.2
10.5
94
455
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
10.5
173
1038
Z2446
NOMESCO Finland
Social worker
2.3
10.5
81
369
C08CA05
ATC
nifedipine; systemic
2.4
10.5
71
305
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
111.2
10.4
11
*
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
3.2
10.4
40
127
399
Kela drug reimbursment
Venetoclax
16.2
10.4
16
10
WZC00
NOMESCO Finland
Treatment plan or consultation
1.6
10.4
337
2426
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
3.3
10.4
38
117
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
8.9
10.3
21
24
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
3.9
10.3
30
79
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
23.7
10.3
14
6
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.1
10.1
102
518
A05AA02
ATC
ursodeoxycholic acid; oral
4.4
10.1
25
58
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
11.4
10.1
18
16
B05DA
ATC
Isotonic solutions
9.3
10.0
20
22
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
7.7
9.9
22
29
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
2.9
9.9
46
163
120
Kela drug reimbursment
Hypogammaglobulinaemia
26.3
9.8
13
5
107
Kela drug reimbursment
Pernicious anaemia
4.1
9.8
27
68
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
20.3
9.8
14
7
ZX112
NOMESCO Finland
Subcutaneous
3.5
9.8
33
96
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
9.7
9.8
19
20
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.1
9.7
96
484
K29.7
ICD-10 Finland
Gastritis, unspecified
3.0
9.7
43
149
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.5
9.5
59
243
A46
ICD-10 Finland
Erysipelas
1.8
9.5
149
878
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
15.2
9.5
15
10
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
15.2
9.5
15
10
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
9.5
253
1727
A07AA02
ATC
nystatin; oral
2.4
9.5
64
275
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
30.3
9.4
12
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.0
9.4
107
568
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
4.4
9.4
23
53
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
8.1
9.4
20
25
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.0
9.3
111
598
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
10.8
9.3
17
16
C03DA01
ATC
spironolactone; oral
1.8
9.3
138
800
AA1AD
NOMESCO Finland
CT of head and brain
1.6
9.2
290
2062
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.6
9.1
54
218
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
3.7
9.0
28
77
Z99.2
ICD-10 Finland
Dependence on renal dialysis
37.1
9.0
11
*
6753
FHL
Transabdominal splenectomy
37.1
9.0
11
*
WX002
NOMESCO Finland
Sedation and analgesia
1.7
9.0
188
1204
C08CA01
ATC
amlodipine; oral
1.5
8.9
373
2820
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
3.8
8.9
27
73
C83.00
ICD-10 Finland
Lymphocytic lymphoma
24.3
8.9
12
5
WVA20
NOMESCO Finland
Medicine administration
3.0
8.9
39
134
N19
ICD-10 Finland
Unspecified kidney failure
2.6
8.9
50
197
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
8.8
331
2446
Z94.4
ICD-10 Finland
Liver transplant status
14.2
8.7
14
10
N02AX02
ATC
tramadol; systemic, rectal
1.5
8.7
393
3017
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
50.5
8.7
10
*
R31
ICD-10 Finland
Unspecified haematuria
1.9
8.6
119
674
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
3.7
8.6
27
75
TPH40
NOMESCO Finland
Insertion of a long peripheral venous catheter
8.3
8.6
18
22
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.2
8.6
33
105
L03AA13
ATC
pegfilgrastim; parenteral
2.5
8.5
52
213
PBU84
NOMESCO Finland
Plastic repair of arteriovenous fistula from artery of upper extremity
27.8
8.5
11
*
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
27.8
8.5
11
*
WZC30
NOMESCO Finland
Teaching
1.7
8.4
154
949
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
90.8
8.4
9
*
A02BC01
ATC
omeprazole; systemic
1.6
8.4
259
1825
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.9
8.4
109
605
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.3
8.4
63
284
R59.9
ICD-10 Finland
Enlarged lymph nodes, unspecified
4.9
8.4
18
37
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
3.8
8.4
25
67
C01BD01
ATC
amiodarone; systemic
3.1
8.3
34
112
2830X
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA NUD]
+∞
8.3
8
*
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
3.9
8.3
24
63
H03AA01
ATC
levothyroxine sodium; systemic
1.6
8.2
207
1391
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
2.9
8.1
37
130
R4190
NOMESCO Finland
Nutritional therapy
2.6
8.1
47
188
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.9
8.1
38
136
V03AE03
ATC
lanthanum carbonate; oral
11.8
8.1
14
12
P01BA02
ATC
hydroxychloroquine; oral
2.1
8.0
79
397
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.6
8.0
227
1565
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
22.2
8.0
11
5
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
8.0
341
2575
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.3
8.0
29
89
RD210, ,
NOMESCO Finland
3.8
7.9
24
65
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
4.0
7.9
22
56
1518, ,
Kela drug reimbursment
13.2
7.9
13
10
C09CA06
ATC
candesartan; oral
1.6
7.9
213
1453
AB2
HP
AVR bio, stent
10.9
7.8
14
13
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
10.9
7.8
14
13
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
7.8
183
1206
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
7.8
135
820
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
6.4
7.7
19
30
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
15.2
7.7
12
8
A41.8
ICD-10 Finland
Other specified sepsis
3.3
7.7
29
91
A12AA12
ATC
[U] calcium acetate
18.5
7.6
11
6
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.5
7.6
47
194
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
7.6
230
1609
XG410
NOMESCO Finland
Flow-volume spirometry
2.6
7.6
44
176
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
25.2
7.6
10
*
AC4
HP
MVP
10.1
7.5
14
14
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
2.3
7.5
57
258
J01DB01
ATC
cefalexin; oral
1.6
7.5
737
6551
WX202
NOMESCO Finland
Supraclavicular plexus blockade
4.3
7.5
19
45
1AA09, ,
NOMESCO Finland
80.7
7.4
8
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
80.7
7.4
8
*
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
7.7
7.4
16
21
104
Kela drug reimbursment
Thyroid insufficiency
2.1
7.4
69
341
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
7.3
155
992
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.3
7.3
57
261
N08.2*D57.8
ICD-10 Finland
Glomerular disorders in sickle-cell disorders
+∞
7.3
7
*
D46.0
ICD-10 Finland
Refractory anaemia without ring sideroblasts, so stated
+∞
7.3
7
*
N08.2*D89.82
ICD-10 Finland
Nepropathy caused by deposition of the light chain of the immunoglobulins
+∞
7.3
7
*
J01CA04
ATC
amoxicillin; systemic
1.6
7.3
730
6488
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
4.2
7.3
19
46
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
9.5
7.3
14
15
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
3.9
7.3
21
55
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
7.3
310
2332
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.1
7.2
70
350
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
15.9
7.2
11
7
K78
ICPC
Atrial fibrillation/flutter
1.9
7.2
88
478
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
7.4
7.2
16
22
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
20.2
7.1
10
5
205
Kela drug reimbursment
Chronic hypertension
1.5
7.1
259
1883
C07AB02
ATC
metoprolol; systemic
1.6
7.1
197
1348
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
4.1
7.1
19
47
C07AG02
ATC
carvedilol; oral
2.1
7.1
65
319
N05CF01
ATC
zopiclone; oral
1.5
7.0
288
2146
TKC20
NOMESCO Finland
Catheterisation of bladder
2.0
7.0
73
375
T81.9
ICD-10 Finland
Unspecified complication of procedure
3.5
7.0
23
66
I34.01
ICD-10 Finland
Mitral (valve) regurgitation NOS or of specified cause, except rheumatic
7.1
7.0
16
23
B01AB04
ATC
dalteparin; parenteral
2.3
7.0
53
240
RS221, ,
NOMESCO Finland
3.9
7.0
20
52
F43.29
ICD-10 Finland
Adaptation disorder UNS
3.4
7.0
24
71
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
2.9
7.0
32
113
B80
ICPC
Iron deficiency anaemia
2.9
7.0
32
113
D70.82
ICD-10 Finland
Drug-induced neutropenia
3.7
6.9
21
57
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.8
6.9
100
574
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
7.6
6.9
15
20
H05BX01
ATC
cinacalcet; oral
7.6
6.9
15
20
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
7.6
6.9
15
20
9989/3-C42.1
ICD-O-3
Myelodysplastic syndrome, NOS, of bone marrow
13.9
6.9
11
8
N02AA05
ATC
oxycodone; systemic
1.6
6.9
184
1249
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
8.3
6.8
14
17
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
9.4
6.8
13
14
V03AE04
ATC
calcium acetate and magnesium carbonate; systemic
40.3
6.8
8
*
I50.1
ICD-10 Finland
Left ventricular failure
2.2
6.7
56
264
JJC00
NOMESCO Finland
Allogenic transplantation of liver
22.7
6.7
9
*
L01BB05
ATC
fludarabine; systemic
22.7
6.7
9
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
6.7
132
830
RS220, ,
NOMESCO Finland
4.1
6.6
18
45
FKC50
NOMESCO Finland
Repair of mitral valve for insufficiency using prosthetic chord
7.9
6.6
14
18
J94.8
ICD-10 Finland
Other specified pleural conditions
3.6
6.6
21
59
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.1
6.6
61
300
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
6.6
175
1184
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.3
6.6
48
214
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.5
6.6
39
158
C88.0
ICD-10 Finland
Waldenström macroglobulinaemia
12.3
6.6
11
9
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
8.8
6.6
13
15
A10AE04
ATC
insulin glargine; parenteral
1.8
6.5
94
539
LEB00
NOMESCO Finland
Biopsy of vagina
3.7
6.5
20
55
UKC02
NOMESCO Finland
Cystoscopy
1.6
6.5
160
1064
81
HP
Angiography of the heart and coronary arteries
2.0
6.5
70
365
C93.1
ICD-10 Finland
Chronic myelomonocytic leukaemia
70.3
6.4
7
*
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
70.3
6.4
7
*
R80
ICD-10 Finland
Isolated proteinuria
7.5
6.4
14
19
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
7.5
6.4
14
19
321
Kela drug reimbursment
Paricalcitol and cinacalcet
6.6
6.3
15
23
S97
ICPC
Chronic ulcer skin
2.0
6.3
70
368
D69.5
ICD-10 Finland
Secondary thrombocytopenia
11.1
6.3
11
10
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
9.3
6.3
12
13
RS222, ,
NOMESCO Finland
3.9
6.3
18
47
1512
Kela drug reimbursment
Ibrutinib
18.2
6.3
9
5
390
Kela drug reimbursment
Ibrutinib
18.2
6.3
9
5
28391
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria secundaria
+∞
6.3
6
*
D58.9
ICD-10 Finland
Hereditary haemolytic anaemia, unspecified
+∞
6.3
6
*
6112
FHL
Installation of a peritoneal dialysis or lavage catheter in an operating room
+∞
6.3
6
*
4AA25, ,
NOMESCO Finland
+∞
6.3
6
*
D55.9
ICD-10 Finland
Anaemia due to enzyme disorder, unspecified
+∞
6.3
6
*
AC1
HP
MVR mechanical
26.9
6.2
8
*
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
2.6
6.1
33
128
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
12.6
6.1
10
8
212
Kela drug reimbursment
Gout
3.1
6.1
24
78
Z95.3
ICD-10 Finland
Presence of xenogenic heart valve
8.7
6.1
12
14
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.9
6.1
81
454
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
10.1
6.0
11
11
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.2
6.0
17
33
A06AD11
ATC
lactulose; oral
1.6
6.0
146
966
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
6.1
6.0
15
25

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
605
1069
14.02
307.65
15.8
2.4
3.25
1.78
%
40.78
582
964
520
400
27.79
307.65
8.6
1.6
0.88
1.49
g/l
21.48
378
357
540
831
13.88
307.65
15.3
2.3
117.40
68.27
e9/l
24.18
428
627
408
207
34.01
307.65
4.8
1.4
—
—
—
0
0
194
77
31.47
285.55
1.4
1.2
—
—
—
0
0
201
132
19.09
237.85
1.5
1.7
—
—
—
0
0
344
664
7.59
184.73
4.9
2.6
9.80
10.68
g/l
1.59
330
616
307
534
8.05
181.50
2.7
1.6
1.71
1.45
g/l
0.68
286
492
489
1386
6.26
174.61
5.3
2.6
2.17
2.30
g/l
6.06
466
1294
145
92
18.45
173.07
1.4
1.3
—
—
—
0
0
506
1491
6.17
172.59
5.5
2.6
14.74
12.78
umol/l
5.01
483
1397
225
303
9.44
164.88
3.3
3.9
51.57
69.90
mg/l
0.40
198
259
224
304
9.36
163.03
3.3
3.9
28.18
55.04
mg/l
1.53
197
262
458
1290
5.96
162.74
5.5
2.6
27.55
22.36
%
7.74
442
1214
206
272
9.41
152.84
3.3
3.7
6.34
2.55
ratio
0.46
124
164
104
45
25.86
146.28
3.6
1.5
129.82
67.76
mg/l
2.16
96
34
331
767
6.11
143.94
3.5
2.9
65.11
66.53
g/l
1.98
317
708
296
626
6.44
141.67
3.4
2.5
—
—
—
0
0
159
197
9.51
123.08
2.2
1.7
—
—
—
0
0
213
372
7.11
122.30
3.3
2.2
3.23
3.75
g/l
2.90
203
339
213
373
7.09
121.96
3.3
2.2
5.88
7.45
g/l
26.28
203
339
213
373
7.09
121.96
3.3
2.2
3.89
4.21
g/l
4.75
203
339
264
573
6.01
121.41
1.6
1.4
—
—
—
0
0
204
348
7.21
119.65
3.4
2.3
2.86
3.03
g/l
1.33
194
314
106
74
16.01
119.50
1.2
1.2
—
—
—
0
0
144
171
9.76
114.96
1.7
1.4
—
—
—
0
0
322
875
5.07
113.71
2.2
1.6
—
—
—
0
0
564
2377
4.42
110.85
3.8
2.3
3.86
2.93
mg/l
8.65
522
2048
136
165
9.46
106.57
1.4
1.3
270.07
256.64
u/ml
0.14
83
90
328
970
4.65
103.00
5.7
2.8
11.36
8.64
umol/l
1.32
305
851
363
1170
4.42
101.59
2.3
1.6
—
—
—
0
0
179
324
6.59
98.21
3.5
2.2
9.86
10.58
g/l
0.84
168
288
602
2844
4.09
96.32
16.3
5.9
—
—
—
0
0
113
129
9.82
92.46
12.0
1.8
1.52
0.88
%
5.98
98
90
123
157
8.86
92.24
1.7
1.4
145.06
166.87
au/ml
0.89
33
43
153
256
6.94
90.35
1.5
1.3
—
—
—
0
0
355
1223
4.05
88.89
15.9
6.0
1.13
1.06
mmol/l
3.90
341
1128
151
259
6.75
86.94
3.8
1.4
0.19
0.24
g/l
6.69
136
249
708
3936
4.22
84.86
16.3
6.0
57.65
57.61
%
0.02
690
3774
151
266
6.57
84.62
3.7
1.4
1.00
1.19
g/l
9.03
144
254
702
3925
4.09
82.32
17.5
6.2
9.01
8.92
%
0.28
684
3689
700
3918
4.06
81.67
17.3
6.1
2.48
2.87
%
4.91
682
3678
363
1350
3.75
79.95
2.3
1.9
—
—
—
0
0
96
107
9.88
79.74
11.9
1.9
33.52
32.59
pg
1.17
96
107
706
4012
4.03
79.60
17.5
6.1
27.71
27.21
%
0.39
690
3815
696
3919
3.97
79.55
17.5
6.1
0.65
0.67
%
0.39
677
3677
739
4332
4.28
79.52
16.7
6.0
2.28
1.91
e9/l
0.99
682
3816
730
4258
4.17
78.77
16.6
6.0
0.59
0.60
e9/l
0.09
669
3646
731
4269
4.18
78.71
16.6
6.0
0.04
0.04
e9/l
0.09
668
3658
739
4390
4.17
76.54
17.7
6.2
0.16
0.19
e9/l
7.87
685
3838
314
1092
3.81
75.91
1.7
1.3
591.50
446.37
titre
0.85
80
245
264
822
4.07
74.74
18.3
7.4
13.19
10.12
mmol/l
4.49
258
790
735
4426
4.01
72.76
20.4
6.7
18.49
12.38
umol/l
13.61
726
4226
673
3867
3.59
70.86
7.0
3.1
389.73
131.61
ug/l
6.72
647
3594
663
3810
3.50
69.01
12.1
5.2
34.92
35.35
g/l
1.09
642
3580
756
4719
4.05
68.96
24.0
9.3
4.16
4.14
e9/l
0.02
694
4125
104
153
7.52
68.67
1.4
1.2
59.50
36.42
u/l
1.14
93
134
347
1368
3.43
68.03
4.6
2.0
30.26
29.70
s
0.60
339
1319
381
1646
3.21
63.38
2.2
1.4
2.06
2.48
g/l
4.31
299
977
107
177
6.69
63.25
1.4
1.2
—
—
—
0
0
238
775
3.77
62.11
9.1
4.3
0.81
1.12
%
1.29
161
229
66
62
11.37
61.62
3.1
1.8
1066.84
1116.28
e6/l
0.13
58
53
507
2627
3.01
60.33
2.5
1.7
23.02
20.14
nmol/l
1.39
467
2211
442
2143
3.00
59.06
5.7
2.8
370.11
349.33
umol/l
3.08
412
1879
517
2750
2.95
57.90
7.3
2.5
—
—
—
0
0
225
740
3.68
57.47
8.4
4.2
0.66
0.75
%
0.29
149
214
650
3955
3.08
56.04
18.2
7.0
1.21
1.21
mmol/l
1.06
625
3648
338
1466
3.04
54.38
6.3
3.5
0.82
0.82
mmol/l
0.18
325
1386
690
4400
3.12
53.47
20.6
7.6
1.20
1.21
mmol/l
2.10
628
3811
345
1541
2.95
52.29
2.2
1.7
1408.72
1176.06
nmol/l
2.91
284
1162
42
25
17.54
50.77
2.2
1.8
—
—
—
0
0
39
20
20.30
50.46
1.1
1.3
627.27
920.00
titre
—
11
5
209
709
3.50
50.38
9.0
4.1
124.23
89.53
ng/l
3.33
184
622
66
83
8.48
49.57
1.3
1.2
—
—
—
0
0
42
27
16.23
48.84
1.2
1.2
—
—
—
0
0
482
2637
2.70
48.49
13.2
4.1
7.40
7.40
ph
0.14
391
1898
463
2494
2.68
47.91
7.9
4.3
—
—
—
0
0
52
50
10.95
47.65
3.6
1.9
155.70
220.98
e6/l
1.26
44
42
122
294
4.62
47.34
1.4
1.2
—
—
—
0
0
209
736
3.36
47.24
9.7
4.3
0.08
0.14
%
0.57
131
191
66
88
7.99
47.20
2.6
2.4
19.39
49.83
iu/ml
—
14
10
610
3795
2.72
46.60
3.2
2.2
95.12
95.37
pmol/l
0.04
389
1980
406
2077
2.68
46.23
6.4
2.5
—
—
—
0
0
198
695
3.34
44.81
1.7
1.4
—
—
—
0
0
129
341
4.22
44.33
3.1
1.8
20.16
6.48
iu/ml
1.19
34
80
48
48
10.48
42.77
3.7
1.8
550.50
491.16
e6/l
0.27
40
37
71
115
6.60
42.55
1.7
1.2
4.31
4.98
u/ml
0.12
36
58
204
752
3.19
42.40
9.7
4.6
0.07
0.20
%
1.12
123
177
243
995
2.94
41.94
10.9
4.3
7.37
7.38
ph
0.87
167
601
36
23
16.23
41.91
5.8
4.5
—
—
—
0
0
606
3893
2.56
41.09
7.5
2.9
—
—
estimate
—
0
0
397
2103
2.53
40.90
10.1
4.2
85.86
87.19
%
0.40
391
2069
213
842
2.98
38.91
3.5
2.3
0.21
0.21
g/l
0.01
202
782
41
38
11.23
38.42
3.4
2.9
1522.93
1356.97
u/ml
0.09
41
38
229
952
2.86
38.06
11.3
4.3
1.06
1.97
mmol/l
3.33
199
783
57
84
7.16
37.26
6.7
4.5
—
—
—
0
0
233
993
2.79
36.82
11.1
4.3
5.64
5.79
kpa
1.67
227
959
34
25
14.07
36.66
3.4
2.5
0.64
0.61
mmol/l
0.98
34
25
56
85
6.94
35.62
1.9
2.6
—
—
—
0
0
53
80
6.96
33.87
3.2
2.2
—
—
—
0
0
93
235
4.28
33.69
1.4
1.2
84.62
95.83
titre
0.16
13
24
471
2865
2.29
33.67
6.7
3.6
48.56
81.49
e6/l
0.69
398
2231
511
3222
2.28
33.41
8.0
4.2
90.59
121.48
e6/l
0.39
406
2319
600
4050
2.33
33.22
33.8
16.5
1.44
1.29
inr
5.80
531
3399
195
807
2.79
32.22
18.1
9.5
—
—
—
0
0
41
50
8.53
31.43
1.5
1.9
—
—
—
0
0
687
4985
2.40
31.05
11.8
5.5
6.90
6.71
mmol/l
1.25
657
4736
258
1264
2.43
29.88
2.7
2.1
—
—
—
0
0
66
139
5.03
29.88
1.1
1.1
—
—
—
0
0
446
2747
2.18
29.82
4.8
3.4
2216.35
1483.93
ng/l
2.48
394
2375
331
1814
2.27
29.52
3.8
1.7
2.85
1.39
mg/l
2.04
285
1438
64
133
5.09
29.42
1.1
1.0
—
—
—
0
0
414
2487
2.19
29.37
6.5
3.4
0.52
0.46
e6/l
0.17
337
1872
35
38
9.53
29.30
2.1
1.7
—
—
—
0
0
61
122
5.28
29.28
1.8
1.5
—
—
—
0
0
61
122
5.28
29.28
1.8
1.5
—
—
—
0
0
61
122
5.28
29.28
1.8
1.5
—
—
—
0
0
61
122
5.28
29.28
1.8
1.5
—
—
—
0
0
41
55
7.75
29.04
2.2
2.7
31.99
38.38
%
0.80
19
29
43
64
6.99
27.80
1.2
1.1
93.33
85.45
titre
—
9
11
788
6205
2.65
27.77
22.2
8.3
84.11
81.04
u/l
1.25
773
5865
352
2022
2.18
27.57
4.9
2.8
4.46
5.26
e6/l
0.46
324
1841
275
1429
2.31
27.54
5.4
3.3
2.60
2.24
e6/l
0.27
174
739
38
50
7.88
27.35
1.8
1.6
15.69
13.25
umol/l
0.64
38
45
542
3686
2.11
27.06
31.7
11.5
0.10
0.00
e9/l
0.56
457
3017
316
1758
2.20
26.67
5.9
3.1
496.02
534.19
mosm/kgh2o
3.02
289
1544
408
2511
2.10
26.45
15.9
6.2
—
—
—
0
0
217
1034
2.43
26.36
4.6
3.0
4.27
5.51
e9/l
1.16
196
900
60
131
4.82
26.01
2.1
1.6
0.72
0.84
g/l
0.29
46
109
540
3705
2.07
25.86
3.8
2.5
75.55
77.95
nmol/l
1.30
504
3309
431
2744
2.05
25.14
6.6
3.3
41.27
33.41
u/l
1.49
417
2598
281
1541
2.17
24.20
5.1
3.2
1.31
1.31
e6/l
0.00
181
854
39
62
6.52
23.69
1.2
1.1
—
—
—
0
0
96
318
3.25
23.24
4.7
3.6
643.66
286.21
mg/l
1.44
56
141
78
230
3.61
22.64
1.3
1.2
5.19
2.70
u/ml
—
7
22
179
834
2.42
22.56
2.4
2.1
373.79
384.73
nmol/l
0.30
169
774
77
229
3.57
22.06
1.4
1.2
2.88
5.30
u/ml
0.43
13
33
152
665
2.53
21.92
7.4
4.3
5.05
5.14
kpa
0.61
147
639
410
2657
1.96
21.87
4.1
2.6
65.37
62.23
u/l
0.29
399
2471
150
653
2.54
21.85
7.5
4.3
7.41
7.42
ph
0.51
131
543
73
212
3.65
21.67
5.5
3.5
0.79
0.81
nmol/l
0.08
26
178
445
2977
1.94
21.49
4.7
3.5
2.32
2.36
mmol/l
5.64
409
2698
311
1844
2.02
21.30
11.9
4.6
—
—
—
0
0
199
994
2.27
21.27
2.1
1.7
—
—
—
0
0
77
240
3.40
20.52
1.4
1.2
69.75
14.71
u/ml
—
6
11
35
58
6.23
20.42
1.2
1.1
—
—
—
0
0
102
381
2.88
20.00
3.1
1.9
5.45
2.39
ug/l
0.53
93
335
46
101
4.74
19.80
2.9
2.6
0.88
1.28
g/24h
0.71
33
57
26
10
26.68
19.20
10.6
8.8
6.58
5.63
mmol/l
—
26
10
198
1062
2.09
17.38
12.8
8.6
7.43
7.42
ph
0.91
118
627
61
183
3.49
17.23
1.4
1.2
51.75
50.71
u/ml
—
8
21
194
1053
2.06
16.41
12.8
8.6
0.60
1.01
mmol/l
0.80
159
867
196
1068
2.05
16.41
12.9
8.5
4.82
5.11
kpa
4.06
189
1032
196
1069
2.05
16.36
12.9
8.5
11.76
12.01
kpa
0.31
187
1034
275
1687
1.89
16.30
6.0
4.2
261.85
369.77
ng/l
0.57
237
1364
26
17
15.69
16.25
1.1
1.0
—
—
—
0
0
156
786
2.18
16.00
3.9
2.4
40.33
96.10
u/l
0.44
141
660
31
59
5.40
15.69
1.0
1.1
—
—
—
0
0
179
960
2.07
15.58
13.4
8.9
95.55
95.51
%
0.03
170
930
573
4415
1.76
15.41
6.7
4.2
37.79
1.93
estimate
1.17
135
976
676
5473
1.83
15.28
7.3
5.0
969.36
2925.59
e6/l
0.84
11
88
26
20
13.33
15.24
1.5
1.5
39.58
30.40
%
0.93
26
20
36
81
4.58
15.05
1.6
1.4
—
—
—
0
0
566
4375
1.74
14.76
6.8
4.2
0.00
0.00
estimate
-0.00
130
951
392
2742
1.74
14.66
4.3
3.4
—
—
—
0
0
573
4451
1.73
14.61
6.8
4.2
0.02
0.34
estimate
0.47
123
912
35
79
4.56
14.58
1.6
1.4
6.59
6.83
g/l
0.06
24
64
35
79
4.56
14.58
1.6
1.4
1.98
2.88
g/l
1.75
25
63
35
79
4.56
14.58
1.6
1.4
0.39
0.42
g/l
0.13
22
63
107
483
2.37
14.19
8.2
4.7
—
—
—
0
0
447
3262
1.70
14.18
5.9
4.1
42.19
73.79
ng/l
0.76
360
2445
32
69
4.77
14.08
1.3
1.1
—
—
—
0
0
139
712
2.12
13.56
2.4
2.6
12.40
7.61
ug/l
0.65
127
634
22
35
6.41
13.33
2.3
1.8
42.57
39.77
g/l
1.60
22
35
376
2656
1.69
13.20
2.7
2.2
200.07
251.87
u/l
0.35
361
2517
473
3555
1.66
13.04
5.8
3.7
6.18
6.25
ph
0.71
246
1999
189
1107
1.88
12.55
1.4
1.2
—
—
—
0
0
62
229
2.83
12.38
3.6
3.2
5.41
1.98
index
1.02
29
123
296
2011
1.69
11.73
5.3
4.0
—
0.20
—
0
25
55
196
2.92
11.72
6.8
2.8
57.84
59.21
%
0.24
55
196
382
2773
1.64
11.69
5.3
3.5
152.77
55.56
mg/l
1.33
294
1806
401
2948
1.63
11.65
5.9
3.5
6.76
7.54
mmol/l
3.27
351
2487
92
426
2.29
11.48
2.8
2.5
—
—
—
0
0
329
2313
1.65
11.36
5.4
3.3
0.40
0.03
—
5
63
33
87
3.89
11.27
1.2
1.2
—
—
—
0
0
86
391
2.32
11.20
7.5
5.1
24.04
24.83
mmol/l
1.47
81
365
264
1769
1.68
10.89
3.5
3.0
2.44
2.46
mmol/l
1.21
235
1589
133
725
1.97
10.85
4.1
3.2
358.67
216.69
ng/l
2.05
124
671
129
700
1.98
10.66
1.7
1.8
—
—
—
0
0
34
97
3.60
10.40
1.2
1.2
—
—
—
0
0
19
18
10.75
10.30
3.3
1.9
0.13
0.29
e9/l
—
10
5
21
25
8.57
10.08
1.3
1.0
—
—
—
0
0
53
202
2.72
10.00
1.2
1.4
398.58
247.20
miu/ml
0.88
12
97
381
2850
1.57
9.81
6.4
4.2
20.94
9.64
mg/mmol
2.60
286
1799
29
78
3.80
9.65
1.1
1.1
—
—
—
0
0
20
24
8.49
9.59
1.3
1.3
28.25
27.37
s
0.21
20
24
166
1016
1.77
9.36
1.8
1.5
—
—
—
0
0
318
2307
1.57
9.24
1.7
1.5
—
—
—
0
0
615
5160
1.55
9.13
5.8
3.4
56.48
50.33
u/l
0.94
586
4838
22
50
4.48
9.12
1.0
1.1
—
—
—
0
0
33
101
3.35
9.10
1.2
1.1
—
—
—
0
0
19
23
8.41
9.09
1.0
1.0
—
—
—
0
0
26
68
3.90
9.00
1.6
1.3
—
—
—
0
0
16
15
10.83
8.81
1.4
1.5
—
—
—
0
0
135
794
1.82
8.67
2.9
2.2
0.00
0.02
estimate
0.50
32
164
18
22
8.32
8.60
1.1
1.1
—
—
—
0
0
32
100
3.28
8.55
1.7
1.4
42140.63
104571.38
e6/l
0.39
19
53
48
189
2.62
8.53
5.8
3.8
—
—
—
0
0
149
916
1.74
8.22
3.7
4.4
8.18
24.56
ug/l
0.95
126
768
258
1829
1.57
8.11
2.0
1.8
475.99
19070207.48
pmol/l
1.20
215
1505
401
3141
1.48
7.81
2.8
2.2
—
—
—
0
0
34
117
2.98
7.77
1.6
1.3
784.86
1593.83
e6/l
1.37
21
78
42
166
2.60
7.43
7.9
2.9
10.75
8.75
pmol/l
0.59
42
166
43
173
2.56
7.34
4.2
2.4
14.58
16.03
%
1.83
43
168
67
328
2.12
7.32
2.1
1.6
0.18
0.32
mg/l
1.38
14
156
7
0
+∞
7.30
4.4
0.0
—
—
—
0
0
842
7763
1.80
7.16
46.4
17.1
21.07
25.32
mg/l
5.88
774
6465
77
401
2.00
7.14
1.2
1.2
—
—
—
0
0
32
112
2.92
7.11
2.7
2.8
—
—
—
0
0
56
261
2.22
6.92
1.5
1.6
36.64
11.65
u/ml
1.02
11
53
57
269
2.19
6.84
10.8
8.0
1.18
1.27
mmol/l
0.36
45
241
207
1452
1.55
6.67
1.4
1.3
48.02
32.73
iu/ml
0.74
63
450
27
90
3.06
6.54
6.0
5.5
9.54
10.70
%
1.08
27
90
15
23
6.61
6.35
6.3
5.1
46.03
50.22
%
0.21
15
23
35
137
2.61
6.34
1.6
1.5
26.18
31.60
g/l
1.58
30
122
29
103
2.87
6.30
1.2
1.1
1.60
1.55
g/l
0.32
29
94
190
1340
1.52
5.92
1.3
1.3
43.89
13.38
u/ml
0.40
54
486
155
1060
1.55
5.54
1.4
1.3
—
—
—
0
0
26
95
2.79
5.40
2.7
1.8
88.95
89.89
%
0.48
26
95
147
999
1.56
5.40
3.4
2.3
170.51
125.57
ug/g
0.96
123
795
27
102
2.70
5.28
1.6
1.6
—
—
—
0
0
12
18
6.74
5.26
2.9
1.1
15.10
16.69
umol/l
0.54
12
13
25
91
2.79
5.23
1.4
1.8
69.35
64.35
%
0.34
19
63
20
64
3.17
5.21
1.1
1.1
109.85
101.34
pmol/l
0.19
20
64
119
777
1.61
5.18
6.4
4.2
7.37
7.35
ph
0.74
97
560
10
12
8.41
5.07
1.3
1.6
—
—
—
0
0
10
12
8.41
5.07
2.2
3.0
—
—
—
0
0
37
166
2.28
5.07
7.4
4.6
2.75
2.77
mmol/l
0.02
24
110
17
50
3.44
5.04
3.9
2.6
511.65
484.00
min
0.55
17
31
31
129
2.45
5.01
2.0
2.9
—
—
—
0
0
13
24
5.48
4.92
3.7
1.5
—
—
—
0
0
9
10
9.07
4.79
1.7
1.4
—
—
—
0
0
242
1860
1.41
4.74
1.4
1.3
2.19
1.98
u/ml
0.06
54
495
106
688
1.61
4.73
11.2
3.6
1.22
1.23
mmol/l
1.15
99
590
135
927
1.53
4.72
1.5
1.3
—
—
—
0
0
70
410
1.76
4.58
2.5
2.2
0.00
2.02
estimate
0.50
24
124
307
2471
1.36
4.50
6.7
4.2
0.02
0.01
estimate
0.26
115
882
42
209
2.06
4.48
1.3
1.2
—
—
—
0
0
35
162
2.21
4.48
1.5
1.6
—
—
—
0
0
16
49
3.30
4.48
1.9
1.5
28.56
22.31
umol/l
0.29
16
42
10
15
6.72
4.47
2.0
1.3
—
—
—
0
0
73
437
1.73
4.44
7.1
4.1
1.02
1.02
ratio
0.76
67
412
14
33
4.29
4.33
1.8
1.2
—
—
—
0
0
17
56
3.07
4.25
4.9
2.8
1.00
0.89
index
0.21
17
56
25
102
2.49
4.24
1.7
1.4
—
—
—
0
0
840
7929
1.55
4.22
51.7
20.9
139.14
139.62
mmol/l
6.06
830
7766
9
13
6.98
4.17
3.4
3.0
—
—
—
0
0
36
174
2.11
4.16
1.6
1.3
57.93
61.86
mmol/l
0.25
28
145
49
265
1.90
4.16
1.4
1.4
267.04
280.46
ug/g
0.21
40
162
19
68
2.83
4.14
3.4
3.5
186.82
19.32
mg/l
1.36
14
52
20
74
2.74
4.10
1.4
1.1
—
—
—
0
0
40
203
2.01
4.07
14.0
8.8
11.06
11.24
mmol/l
0.11
34
187
40
203
2.01
4.07
14.0
8.8
106.09
105.32
mmol/l
0.39
34
187
22
86
2.60
4.07
5.5
3.0
13.47
12.86
index
0.08
17
56
250
1979
1.36
4.01
6.2
4.3
1.07
1.02
kg/l
0.49
181
1340
16
53
3.05
3.98
3.8
1.9
141.34
107.04
ng/l
0.51
16
53
11
23
4.83
3.88
1.7
1.1
—
—
—
0
0
10
19
5.31
3.83
1.5
1.5
7.98
8.83
mmol/l
—
10
19
838
7938
1.50
3.78
54.1
21.1
4.04
3.99
mmol/l
5.84
825
7757
225
2796
0.74
3.66
4.2
3.3
—
—
—
0
0
7
9
7.83
3.56
1.6
2.4
—
—
—
0
0
43
236
1.86
3.53
1.2
1.2
—
—
—
0
0
390
3336
1.29
3.52
6.8
4.1
0.05
0.03
estimate
0.17
110
804
33
167
2.01
3.42
3.2
1.4
1.17
0.88
nmol/l
1.48
27
142
39
210
1.89
3.40
3.8
2.5
103.11
104.56
ug/min
0.01
29
122
20
84
2.41
3.24
1.3
1.1
—
—
—
0
0
7
11
6.40
3.19
1.0
1.3
—
—
—
0
0
7
11
6.40
3.19
1.6
1.5
—
—
—
0
0
38
210
1.84
3.08
3.7
2.1
118.69
128.84
g/l
1.47
32
165
286
2385
1.29
3.07
7.0
3.6
0.03
0.04
estimate
0.11
100
772
664
6125
1.28
3.06
5.0
4.3
14.98
14.91
pmol/l
0.27
613
5569
22
100
2.23
3.01
1.7
1.5
31.30
25.07
ng/l
0.32
22
100
21
94
2.26
2.98
1.3
1.2
—
—
—
0
0
70
463
1.55
2.95
3.6
3.5
4.03
4.57
pmol/l
3.64
60
409
59
375
1.61
2.94
1.2
1.3
—
—
—
0
0
845
8084
1.44
2.93
29.4
12.4
25.59
25.48
u/l
0.07
835
7831
765
7224
1.31
2.73
6.4
5.4
2.07
1.94
mu/l
1.67
722
6617
17
73
2.35
2.66
1.4
1.4
—
—
—
0
0
10
31
3.25
2.52
2.7
3.3
—
—
—
0
0
33
555
0.58
2.49
1.2
1.4
—
—
—
0
0
15
63
2.40
2.47
1.2
1.3
—
—
—
0
0
848
8160
1.39
2.43
55.3
22.7
100.49
79.42
umol/l
11.60
839
8053
7
17
4.14
2.36
7.1
2.1
1.00
2.59
%
—
7
17
7
17
4.14
2.36
2.3
1.9
—
—
—
0
0
7
17
4.14
2.36
1.6
1.2
—
—
—
0
0
10
33
3.05
2.36
1.3
1.5
—
—
—
0
0
54
358
1.54
2.30
3.2
2.8
—
—
—
0
0
10
34
2.96
2.28
2.7
3.1
—
—
—
0
0
6
13
4.64
2.27
1.0
1.0
—
—
—
0
0
5
9
5.58
2.21
3.0
2.9
—
—
—
0
0
7
19
3.70
2.15
1.3
1.2
—
—
—
0
0
14
61
2.31
2.15
1.3
1.5
37.92
24.95
%
—
9
42
9
30
3.02
2.15
1.0
1.1
154.42
187.39
iu/ml
—
9
30
332
2913
1.22
2.15
5.6
3.8
—
0.78
—
0
9
13
56
2.34
2.05
1.0
1.5
0.91
1.04
promille
—
8
47
10
38
2.65
2.01
1.0
1.3
0.94
4.79
u/ml
—
5
15
27
156
1.75
1.98
1.3
1.3
—
—
—
0
0
30
180
1.69
1.94
1.1
1.3
4.01
3.75
mmol/l
0.44
25
170
20
107
1.89
1.87
1.1
1.2
—
—
—
0
0
17
87
1.97
1.80
2.8
2.1
—
—
—
0
0
74
551
1.37
1.78
1.3
1.2
159.17
240.85
u/ml
0.55
59
505
30
185
1.64
1.77
1.4
1.3
1037.48
124.73
e6/l
0.63
21
152
821
7927
1.28
1.76
41.3
15.5
—
—
—
0
0
18
96
1.89
1.71
1.1
1.2
—
—
—
0
0
88
679
1.33
1.69
8.9
3.9
—
—
—
0
0
13
63
2.08
1.60
3.3
2.1
18.09
32.74
mg/l
—
8
42
29
183
1.60
1.59
1.3
1.3
5.78
12.19
e6/l
0.62
18
146
12
58
2.08
1.49
1.1
1.1
317.33
289.36
mg/l
0.44
12
53
5
16
3.14
1.44
1.8
1.6
1.43
1.28
umol/l
—
5
10
10
46
2.19
1.40
1.0
1.3
125.00
144.20
nmol/l
—
10
46
14
74
1.91
1.39
2.4
2.6
8.55
7.01
mmol/l
—
8
49
11
53
2.09
1.39
1.3
1.5
92.55
81.62
umol/l
0.91
11
53
82
648
1.29
1.36
4.1
2.9
5.94
6.11
ph
1.02
62
446
35
240
1.48
1.36
1.6
1.6
24638.12
16050.20
e6/l
0.40
26
172
140
1651
0.82
1.36
3.1
3.3
0.93
0.78
ug/l
0.61
109
1099
9
44
2.06
1.27
2.0
1.6
44.89
50.29
ug/l
—
9
44
81
648
1.27
1.24
1.1
1.2
—
—
—
0
0
5
19
2.64
1.21
1.4
1.1
—
—
—
0
0
54
410
1.34
1.21
3.1
2.0
—
—
—
0
0
5
20
2.51
1.15
3.4
6.7
5.26
4.94
kpa
—
5
20
7
31
2.27
1.10
2.6
1.9
—
—
—
0
0
7
140
0.50
1.09
1.9
1.7
—
—
—
0
0
763
7400
1.16
1.06
5.8
5.3
6.13
5.98
mmol/l
1.49
698
6725
7
34
2.07
1.03
1.0
1.1
—
21.33
—
0
6
22
322
0.68
1.03
1.0
1.1
—
—
—
0
0
5
23
2.18
0.98
1.4
1.0
—
—
—
0
0
19
125
1.53
0.94
1.7
1.6
—
—
—
0
0
7
37
1.90
0.94
1.4
1.1
—
—
—
0
0
6
27
2.23
0.93
1.8
3.5
5.00
6.37
ug/l
—
6
27
19
129
1.48
0.84
1.9
1.7
—
—
—
0
0
21
146
1.45
0.83
1.7
1.9
—
—
—
0
0
8
46
1.75
0.82
3.3
3.8
67.25
141.24
nmol/l
—
8
46
8
46
1.75
0.82
1.9
1.8
32.88
29.78
umol/l
—
8
41
15
97
1.56
0.81
2.9
1.8
—
—
—
0
0
13
82
1.59
0.78
1.5
1.4
—
—
—
0
0
62
513
1.22
0.77
2.6
2.5
40.26
19.00
au/ml
—
7
38
6
34
1.77
0.76
1.7
1.4
179.83
175.67
mmol/24h
—
6
34
6
34
1.77
0.76
1.2
1.0
1084.67
1454.62
miu/ml
—
6
34
33
253
1.32
0.76
7.0
3.3
1.70
1.57
mmol/l
0.29
33
248
11
67
1.65
0.75
2.2
2.6
8.15
8.16
mmol/l
0.00
11
67
11
67
1.65
0.75
1.1
1.1
29.27
35.36
mmol/l
0.53
11
62
31
237
1.32
0.73
8.6
5.2
—
—
—
0
0
5
25
2.01
0.72
1.0
1.9
16.40
15.74
pmol/l
—
5
19
9
58
1.56
0.70
1.1
1.1
60.33
39.09
mg/l
—
9
49
12
181
0.66
0.69
1.2
1.2
—
—
—
0
0
852
8387
1.17
0.69
73.6
26.2
118.58
133.93
g/l
96.17
847
8278
19
135
1.42
0.69
1.4
1.1
—
—
—
0
0
14
204
0.68
0.69
1.1
1.1
—
—
—
0
0
851
8379
1.16
0.67
73.3
26.0
225.69
246.63
e9/l
11.86
839
8204
56
467
1.21
0.67
1.4
1.3
64.75
49.46
au/ml
—
8
37
19
136
1.41
0.67
1.4
1.1
—
—
—
0
0
851
8381
1.16
0.66
72.9
25.9
93.97
91.17
fl
29.02
845
8276
57
676
0.83
0.65
2.5
2.3
10.53
12.89
nmol/l
1.20
47
603
851
8383
1.16
0.65
73.0
26.0
3.89
4.45
e12/l
89.87
836
8179
851
8383
1.16
0.65
73.1
26.1
7.77
6.85
e9/l
2.07
836
8177
851
8383
1.16
0.65
72.8
25.9
31.12
30.32
pg
17.00
845
8276
851
8383
1.16
0.65
74.9
26.6
35.73
39.99
%
78.69
845
8273
22
292
0.75
0.64
1.9
1.7
—
—
—
0
0
5
29
1.73
0.64
1.0
1.1
—
—
—
0
0
13
87
1.50
0.63
2.2
2.5
—
—
—
0
0
28
217
1.30
0.62
1.2
1.5
10.58
9.50
u/l
0.21
22
174
63
736
0.85
0.62
1.5
1.5
—
—
—
0
0
28
218
1.29
0.60
1.8
1.2
0.90
0.90
g/l
0.00
28
218
0
21
0.00
0.60
0.0
1.1
—
54.73
—
0
21
42
507
0.82
0.59
1.3
1.7
3.77
3.44
mmol/l
0.85
32
373
739
7240
1.10
0.54
8.3
6.8
37.50
39.63
mmol/mol
6.21
682
6743
12
82
1.47
0.54
2.0
2.2
—
—
—
0
0
9
60
1.50
0.54
1.0
1.0
—
—
—
0
0
9
60
1.50
0.54
1.3
1.3
—
—
—
0
0
9
61
1.48
0.53
1.1
1.2
—
7.10
—
0
14
9
63
1.43
0.52
2.8
2.8
14.24
16.13
%
—
9
63
84
747
1.14
0.50
1.7
1.5
—
—
—
0
0
17
128
1.33
0.48
1.2
1.1
1.49
1.80
u/ml
—
6
66
5
31
1.62
0.43
2.8
1.2
40.20
32.75
nmol/l
—
5
24
15
113
1.33
0.43
1.7
1.2
—
0.54
nmol/l
—
0
5
8
56
1.43
0.42
1.0
1.0
347.25
224.80
mg/l
—
8
50
17
131
1.30
0.42
1.2
1.1
14.32
3.63
u/ml
—
7
77
8
60
1.34
0.40
3.5
2.2
19.50
3.63
ug/l
—
8
55
23
280
0.82
0.39
4.9
1.6
—
—
—
0
0
57
509
1.13
0.35
1.4
1.2
130.21
142.26
u/ml
0.07
21
191
18
148
1.22
0.29
1.6
1.1
5.83
1.96
u/ml
0.29
12
88
25
213
1.18
0.29
2.6
1.8
312.52
4.24
iu/l
—
10
81
15
121
1.24
0.28
1.1
1.3
—
—
—
0
0
24
280
0.85
0.28
4.8
1.6
—
—
—
0
0
24
278
0.86
0.26
4.7
1.6
—
—
—
0
0
20
235
0.85
0.26
1.6
1.8
50.25
41.52
nmol/l
0.71
20
225
24
277
0.86
0.25
4.7
1.6
—
—
—
0
0
12
96
1.25
0.24
1.9
1.3
—
—
—
0
0
81
864
0.93
0.22
1.7
1.6
—
—
—
0
0
15
178
0.84
0.22
2.5
4.0
19.40
30.33
mg/l
—
10
127
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
16.59
—
0
11
0
10
0.00
0.21
0.0
1.0
—
10.80
—
0
5
0
12
0.00
0.21
0.0
1.0
—
0.02
—
0
12
757
7501
1.05
0.20
6.0
5.2
4.26
4.53
mmol/l
10.30
705
6938
719
7128
1.04
0.17
5.3
4.3
1.34
1.27
mmol/l
1.45
658
6481
757
7623
0.96
0.15
6.7
6.0
2.40
2.63
mmol/l
10.71
701
7022
22
243
0.90
0.14
2.4
2.2
8576.07
5045.31
u/l
—
8
103
21
191
1.10
0.12
1.4
1.3
—
—
—
0
0
24
260
0.92
0.11
4.7
1.6
—
—
—
0
0
11
125
0.88
0.10
8.6
1.9
—
—
—
0
0
5
44
1.14
0.10
1.6
1.2
158.86
171.63
pmol/l
—
5
44
54
521
1.04
0.07
1.3
1.2
—
—
—
0
0
21
224
0.94
0.06
8.3
11.9
—
—
—
0
0
322
3242
0.99
0.04
2.2
2.0
1.41
1.33
mmol/l
0.95
274
2708
747
7456
1.01
0.02
5.9
5.1
1.40
1.45
mmol/l
2.93
691
6843
20
207
0.97
0.01
1.1
1.1
1.54
1.54
g/l
0.04
20
207
18
186
0.97
0.00
12.4
2.0
—
—
—
0
0
27
274
0.98
0.00
1.1
1.1
—
—
—
0
0
275
2753
1.00
0.00
5.1
5.8
2.60
2.61
ug/l
0.01
251
2457
22
215
1.02
0.00
4.9
1.6
—
—
—
0
0
5
53
0.94
0.00
4.4
2.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
283.80
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
391.60
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
616.44
—
0
5
8
81
0.99
-0.00
1.0
1.1
—
—
—
0
0
7
76
0.92
-0.00
1.1
1.5
274.14
322.25
mu/l
—
7
57
0
5
0.00
-0.00
0.0
1.0
—
0.04
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
38.67
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
70.80
—
0
5

Mortality – FinRegistry

Association

Association between endpoint D3_ACQHAEMOLYTICANAEMIA and mortality.

Females

Parameter HR [95% CI] p-value
D3_ACQHAEMOLYTICANAEMIA 2.809 [2.38, 3.31] < 0.001
Birth year 0.994 [0.99, 1.0] 0.164

During the follow-up period (1.1.1998 — 31.12.2019), 1010 out of 2437 females with D3_ACQHAEMOLYTICANAEMIA died.

Males

Parameter HR [95% CI] p-value
D3_ACQHAEMOLYTICANAEMIA 2.96 [2.45, 3.58] < 0.001
Birth year 0.993 [0.98, 1.0] 0.112

During the follow-up period (1.1.1998 — 31.12.2019), 846 out of 2047 males with D3_ACQHAEMOLYTICANAEMIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_ACQHAEMOLYTICANAEMIA.

N-year risk Females Males
1 0.258% 0.614%
5 1.926% 3.519%
10 4.031% 8.893%
15 7.254% 17.108%
20 12.953% 28.787%

Relationships between endpoints

Index endpoint: D3_ACQHAEMOLYTICANAEMIA – Acquired haemolytic anaemia

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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