hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
78 |
4. Check minimum number of eventsNone |
78 |
5. Include endpointsNone |
78 |
6. Filter based on genotype QC (FinnGen only) |
70 |
Control definitions (FinnGen only)
- Control exclude
- D3_HAEMOLYTICANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D59
- Name in latin
- Aliae anaemiae non autoimmunes haemolyticae
Similar endpoints
↥List of similar endpoints to
Other nonautoimmune haemolytic anaemias
based on the number of shared cases.
Similar with more cases:
- Acquired haemolytic anaemia
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 438 | 222 | 207 |
| Only index persons | 286 | 140 | 146 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 65.19 | 68.72 | 61.30 |
| Only index persons | 61.49 | 62.70 | 60.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 70 | 34 | 36 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 67.82 | 68.72 | 66.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 72
- Matched controls
- 720
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
95.7
69
*
D64.9
ICD-10 Finland
Anaemia, unspecified
16.3
33.1
41
54
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
58.6
21.1
24
6
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
17.4
16
*
B01AA03
ATC
warfarin; systemic
7.3
16.2
38
96
I35.0
ICD-10 Finland
Aortic (valve) stenosis
9.5
15.9
23
34
XW000
NOMESCO Finland
Bone marrow biopsy
26.3
15.4
21
11
C03CA01
ATC
furosemide; systemic
7.2
14.4
52
192
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
47.2
10.3
12
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
17.0
9.1
14
10
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
10.0
9.1
18
23
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
8.2
8.8
20
32
WW500
NOMESCO Finland
Blood transfusion
13.2
8.8
15
14
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
8.5
8
*
I34.1
ICD-10 Finland
Mitral (valve) prolapse
11.5
8.3
15
16
TPH07
NOMESCO Finland
Cathetrisation of artery
5.0
7.9
21
55
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
50.7
7.9
9
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
3.9
7.5
37
154
D59.8
ICD-10 Finland
Other acquired haemolytic anaemias
+∞
7.4
7
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
11.9
7.4
13
13
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.1
7.4
27
91
D64.8
ICD-10 Finland
Other specified anaemias
33.8
7.3
9
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.9
7.0
30
112
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.2
6.9
54
300
B01AB05
ATC
enoxaparin; parenteral
3.6
6.7
39
178
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
76.3
6.5
7
*
K78
ICPC
Atrial fibrillation/flutter
5.0
6.5
16
39
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.3
6.4
15
25
I50.0
ICD-10 Finland
Congestive heart failure
6.2
6.4
17
34
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
11.5
6.3
11
11
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.5
6.2
33
141
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
6.7
6.1
15
27
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
49
38
38.24
57.21
7.3
1.5
0.66
1.79
g/l
6.89
28
32
39
14
58.70
33.68
2.3
1.8
—
—
—
0
0
13
0
+∞
14.00
2.2
0.0
—
—
—
0
0
13
0
+∞
14.00
2.2
0.0
—
—
—
0
0
11
0
+∞
11.77
1.3
0.0
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
19
18
13.88
11.11
8.7
2.1
0.40
0.43
iu/ml
—
14
7
22
48
6.16
10.36
4.8
2.2
251.64
281.03
ng/l
0.11
22
43
20
29
9.11
9.39
7.4
1.3
4.32
1.33
ratio
—
12
10
63
385
6.08
8.19
18.7
7.2
19.95
12.35
umol/l
2.68
63
362
55
302
4.48
7.36
9.3
2.9
—
—
estimate
—
0
0
31
123
3.67
6.59
1.7
1.9
—
—
—
0
0
37
165
3.56
6.57
9.8
2.6
—
—
—
0
0
54
313
3.90
6.22
4.1
2.2
92.49
94.52
pmol/l
0.14
35
159
13
20
7.67
5.88
2.0
1.4
0.20
0.23
g/l
0.51
13
20
13
21
7.30
5.70
1.3
1.2
—
—
—
0
0
47
261
3.31
5.56
7.9
3.5
2890.28
1212.94
ng/l
0.91
47
226
19
61
3.87
5.38
3.2
2.5
0.20
0.21
g/l
0.03
19
55
12
20
6.97
5.17
6.8
2.0
99.50
87.30
%
0.86
12
20
12
20
6.97
5.17
2.1
1.5
1.05
1.18
g/l
0.75
12
20
9
10
10.08
4.94
1.1
1.3
—
—
—
0
0
8
7
12.64
4.91
3.8
1.3
—
—
—
0
0
16
51
3.75
4.53
1.4
1.5
—
—
—
0
0
60
412
3.74
4.53
13.6
5.3
6.81
6.74
mmol/l
0.12
60
388
36
193
2.73
4.20
7.8
3.2
412.42
356.04
umol/l
1.34
36
160
7
7
10.90
4.10
2.3
2.0
1242.57
1148.86
mg
—
7
7
11
23
5.44
4.06
1.5
2.2
—
—
—
0
0
11
25
5.00
3.81
1.5
2.5
—
—
—
0
0
14
46
3.54
3.77
8.3
5.0
24.59
24.44
mmol/l
0.08
14
46
64
513
3.22
3.11
19.6
9.3
80.69
81.65
u/l
0.08
64
490
14
52
3.10
3.10
1.4
1.7
—
—
—
0
0
37
225
2.33
3.06
5.5
2.5
81.00
76.92
u/l
0.05
37
207
5
6
8.83
2.79
2.2
1.3
3.34
5.40
mg/l
—
5
6
19
91
2.48
2.62
1.9
1.7
—
—
—
0
0
35
222
2.12
2.48
4.9
2.8
45.91
32.98
u/l
0.61
35
206
8
24
3.62
2.25
1.3
1.3
—
—
—
0
0
10
37
2.97
2.17
1.4
1.3
—
—
—
0
0
41
288
1.98
2.10
6.8
4.4
77.73
34.79
ng/l
0.91
36
224
7
21
3.58
2.02
1.1
1.7
—
—
—
0
0
20
111
2.11
1.94
17.3
7.2
105.15
103.13
mmol/l
0.67
20
111
5
12
4.39
1.85
1.8
1.1
—
—
—
0
0
17
90
2.16
1.84
2.1
1.7
—
—
—
0
0
6
19
3.35
1.70
1.5
1.2
—
—
—
0
0
11
50
2.42
1.67
15.8
8.7
25.51
25.07
mmol/l
0.11
11
50
21
126
1.94
1.63
6.0
3.5
1.72
3.56
e6/l
0.64
13
66
13
227
0.48
1.60
3.5
5.2
17.21
22.05
%
—
7
118
6
21
3.02
1.54
1.2
1.9
—
—
—
0
0
6
21
3.02
1.54
1.2
2.0
—
—
—
0
0
13
67
2.15
1.49
18.8
8.4
1.40
1.45
mmol/l
0.05
13
67
5
18
2.90
1.30
1.6
1.1
—
—
—
0
0
21
136
1.77
1.27
6.1
3.3
2.36
0.91
e6/l
0.54
13
75
43
339
1.67
1.26
2.7
2.9
—
—
—
0
0
5
19
2.75
1.23
1.0
1.5
—
—
—
0
0
5
19
2.75
1.23
1.2
1.8
—
—
—
0
0
31
230
1.61
1.13
7.2
3.3
0.75
0.40
e6/l
0.42
25
170
17
107
1.77
1.12
1.6
1.4
2.06
12.10
u/ml
—
5
39
44
363
1.55
0.97
6.4
4.5
0.00
0.00
estimate
—
6
85
12
71
1.83
0.96
3.0
2.1
372.17
400.98
nmol/l
0.29
12
62
6
28
2.24
0.94
1.2
1.3
—
—
—
0
0
8
45
1.87
0.88
3.8
2.6
0.90
1.10
%
—
8
45
44
368
1.50
0.87
6.5
4.5
232.00
0.00
estimate
—
7
86
31
243
1.48
0.83
5.3
4.1
45.53
10.58
mg/mmol
0.71
23
156
44
371
1.48
0.82
6.6
4.6
0.00
3.66
estimate
—
6
82
6
40
1.54
0.53
1.5
2.8
—
—
—
0
0
25
206
1.33
0.47
5.7
4.1
0.00
0.36
estimate
—
6
70
32
277
1.28
0.41
6.1
4.5
0.00
0.00
estimate
—
6
75
61
575
1.40
0.39
4.5
4.8
1.32
1.29
mmol/l
0.09
56
524
66
634
1.49
0.35
60.8
22.7
4.05
3.98
mmol/l
1.24
66
623
66
632
1.53
0.35
59.2
22.7
138.55
139.63
mmol/l
2.35
66
621
15
121
1.30
0.32
1.8
1.3
39.28
47.25
iu/ml
—
5
41
9
74
1.25
0.26
1.3
1.4
—
—
—
0
0
66
639
1.39
0.26
26.8
13.9
26.44
24.77
u/l
0.26
66
623
0
10
0.00
0.21
0.0
1.8
—
4.20
—
0
5
0
12
0.00
0.21
0.0
1.1
—
42.50
—
0
6
0
12
0.00
0.21
0.0
1.0
—
495.14
—
0
7
29
263
1.17
0.21
2.2
1.9
1.24
1.29
mmol/l
0.08
22
210
51
485
1.18
0.19
79.9
23.7
330.45
331.95
g/l
0.42
51
485
66
642
1.34
0.16
63.5
25.4
102.89
82.22
umol/l
3.79
66
636
10
83
1.24
0.16
3.8
3.8
—
—
—
0
0
19
210
0.87
0.14
5.8
4.3
0.00
0.00
estimate
—
5
74
8
73
1.11
0.08
10.0
8.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
5.2
—
0.33
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
66
654
1.11
-0.00
89.7
28.2
94.66
91.66
fl
3.01
66
647
66
654
1.11
-0.00
93.5
28.9
33.67
40.02
%
15.24
66
647
66
654
1.11
-0.00
90.7
28.5
110.15
134.63
g/l
17.36
66
646
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
6.54
—
0
5
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
41.10
—
0
5
6
62
0.96
-0.00
1.7
1.3
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
63.14
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint D3_NOCT_HAEMOGLOBINURIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_NOCT_HAEMOGLOBINURIA | 2.556 [1.24, 5.26] | 0.011 |
| Birth year | 0.994 [0.99, 1.0] | 0.161 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 139 females with D3_NOCT_HAEMOGLOBINURIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_NOCT_HAEMOGLOBINURIA | 3.81 [2.25, 6.45] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 138 males with D3_NOCT_HAEMOGLOBINURIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_NOCT_HAEMOGLOBINURIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.305% | 0.681% |
| 5 | 1.497% | 4.41% |
| 10 | 3.57% | 10.283% |
| 15 | 6.782% | 17.758% |
| 20 | 11.725% | 28.367% |
Relationships between endpoints
↥Index endpoint: D3_NOCT_HAEMOGLOBINURIA – Other nonautoimmune haemolytic anaemias
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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