No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
522 |
4. Check minimum number of eventsNone |
522 |
5. Include endpointsNone |
522 |
6. Filter based on genotype QC (FinnGen only) |
443 |
Control definitions (FinnGen only)
- Control exclude
- D3_HAEMOLYTICANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D59
- Name in latin
- Aliae anaemiae autoimmunes haemolyticae
Similar endpoints
↥List of similar endpoints to
Other autoimmune haemolytic anaemias
based on the number of shared cases.
Similar with more cases:
- Acquired haemolytic anaemia
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3078 | 1652 | 1390 |
| Only index persons | 2344 | 1276 | 1068 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 68.37 | 69.80 | 66.65 |
| Only index persons | 67.43 | 68.54 | 66.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 443 | 233 | 210 |
| Unadjusted period prevalence (%) | 0.09 | 0.08 | 0.10 |
| Median age at first event (years) | 65.84 | 64.02 | 67.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 461
- Matched controls
- 4610
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
307.7
438
*
XW000
NOMESCO Finland
Bone marrow biopsy
22.9
186.8
153
98
D64.9
ICD-10 Finland
Anaemia, unspecified
9.8
126.6
199
331
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
30.0
85.6
58
22
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
85.1
79
*
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
46.6
83.9
50
12
WW500
NOMESCO Finland
Blood transfusion
10.5
77.7
95
111
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
9.2
72.5
99
133
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
34.6
68.3
44
14
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
21.9
66.9
51
26
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
12.4
60.3
63
58
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
24.9
59.6
43
19
H02AB06
ATC
prednisolone; systemic
5.6
59.0
357
1755
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.0
53.6
149
399
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.8
44.1
275
1285
ZX120
NOMESCO Finland
Intravenous
4.9
41.1
107
267
M04AA01
ATC
allopurinol; systemic
3.3
25.0
120
449
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.8
23.8
299
1848
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.7
23.8
59
139
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
8.1
23.2
32
42
2830A
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA PRIMARIA]
+∞
23.1
22
*
JN4AD
NOMESCO Finland
Body CT examination
3.3
22.5
100
355
L03AA02
ATC
filgrastim; parenteral
5.7
21.3
41
77
L04AX01
ATC
azathioprine; systemic
5.6
21.2
42
81
JN4BD
NOMESCO Finland
Extensive body CT
3.4
20.7
87
298
D64.8
ICD-10 Finland
Other specified anaemias
8.2
20.6
28
36
H02AB07
ATC
prednisone; oral
3.0
20.0
105
410
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
18.6
96
370
1XC02, ,
NOMESCO Finland
30.2
17.6
23
8
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
17.4
185
1014
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
65.9
16.9
19
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
16.7
143
709
A02BC02
ATC
pantoprazole; systemic
2.5
15.9
357
2648
D59.0
ICD-10 Finland
Drug-induced autoimmune haemolytic anaemia
+∞
15.7
15
*
D59.8
ICD-10 Finland
Other acquired haemolytic anaemias
+∞
14.7
14
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.2
14.6
40
101
H02AB09
ATC
hydrocortisone; systemic
6.1
14.6
26
45
JN6AD
NOMESCO Finland
CT of torso and neck
6.2
14.5
25
42
L01AA02
ATC
chlorambucil; oral
23.2
14.3
20
9
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
5.8
14.0
26
47
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
31.1
14.0
18
6
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
11.4
13.7
25
23
B03BA03
ATC
hydroxocobalamin; parenteral
3.4
13.3
50
158
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.0
13.3
65
241
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
13.2
170
986
6BA02, ,
NOMESCO Finland
51.5
12.9
15
*
28390
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria primaria
+∞
12.6
12
*
UJF32
NOMESCO Finland
Coloscopy
2.1
12.4
155
884
R50.9
ICD-10 Finland
Fever, unspecified
2.4
12.4
100
476
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
12.2
128
681
L01AA01
ATC
cyclophosphamide; systemic
22.0
12.1
17
8
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.5
11.8
42
128
M05BA04
ATC
alendronic acid; oral
2.7
11.7
67
270
L01XX52
ATC
venetoclax; oral
23.6
11.6
16
7
WW200
NOMESCO Finland
Immunization
5.2
11.6
24
48
J05AB11
ATC
valaciclovir; oral
2.4
11.5
93
443
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.8
11.3
26
57
TK800
NOMESCO Finland
Hemodialysis
5.5
11.2
22
42
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.8
11.1
35
98
A10AB05
ATC
insulin aspart; parenteral
2.9
10.9
53
195
JMA10
NOMESCO Finland
Transabdominal total splenectomy
16.0
10.9
17
11
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
18.4
10.8
16
9
B03XA02
ATC
darbepoetin alfa; parenteral
5.1
10.4
22
45
399
Kela drug reimbursment
Venetoclax
19.3
10.3
15
8
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
8.2
10.2
22
28
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
4.1
10.2
28
71
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
15.0
10.1
16
11
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
41.0
10.0
12
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
41.0
10.0
12
*
B82
ICPC
Anaemia other/unspecified
4.2
9.9
27
68
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
9.9
9.9
19
20
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
56.2
9.7
11
*
L04AA06
ATC
mycophenolic acid; systemic
7.4
9.6
22
31
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.2
9.5
38
125
6753
FHL
Transabdominal splenectomy
102.0
9.4
10
*
A41.9
ICD-10 Finland
Sepsis, unspecified
3.5
9.4
32
95
TGC00
NOMESCO Finland
Bronchial lavation
3.9
9.2
27
72
ZX112
NOMESCO Finland
Subcutaneous
4.6
9.2
22
50
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.6
9.1
55
227
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.4
9.1
33
102
A10AC01
ATC
insulin (human); parenteral
2.6
9.0
53
216
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
24.6
8.9
12
5
A04AA01
ATC
ondansetron; systemic, rectal
2.6
8.9
54
223
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
12.9
8.9
15
12
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.9
8.9
44
164
C03CA01
ATC
furosemide; systemic
1.8
8.9
187
1250
J01MA12
ATC
levofloxacin; systemic
2.0
8.7
106
589
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
7.9
8.7
19
25
D70.89
ICD-10 Finland
Neutropenic splenomegaly
8.5
8.7
18
22
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
16.7
8.6
13
8
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
20.5
8.5
12
6
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.7
8.5
46
180
2830X
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA NUD]
+∞
8.4
8
*
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
8.4
8
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
8.2
101
563
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
8.2
73
360
SPAT1088
SPAT
Blood transfusion
17.6
8.1
12
7
PJA10
NOMESCO Finland
Exploration of lymph nodes
8.7
7.9
16
19
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.8
7.9
41
157
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.8
7.8
24
66
1518, ,
Kela drug reimbursment
15.4
7.8
12
8
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.2
7.7
30
97
L04AD01
ATC
ciclosporin; systemic
8.2
7.7
16
20
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
7.6
242
1798
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.5
7.5
18
41
L03AA13
ATC
pegfilgrastim; parenteral
3.0
7.4
34
121
ZX108
NOMESCO Finland
Inhalation
11.1
7.3
13
12
P01BA02
ATC
hydroxychloroquine; oral
2.5
7.1
46
196
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.3
7.1
56
262
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
9.5
6.8
13
14
B01AB05
ATC
enoxaparin; parenteral
1.7
6.8
163
1112
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
17.0
6.8
10
6
ZXD05
NOMESCO Finland
Urgent procedure
1.7
6.7
142
935
C88.0
ICD-10 Finland
Waldenström macroglobulinaemia
22.9
6.7
9
*
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.9
6.7
105
632
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.6
6.6
37
147
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
12.5
6.6
11
9
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
8.9
6.6
13
15
1AA09, ,
NOMESCO Finland
70.8
6.4
7
*
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
70.8
6.4
7
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
70.8
6.4
7
*
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
70.8
6.4
7
*
R06.0
ICD-10 Finland
Dyspnoea
1.7
6.4
149
1005
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
14.6
6.4
10
7
J01MA02
ATC
ciprofloxacin; systemic
1.7
6.4
191
1377
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
18.3
6.3
9
5
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
6.3
98
588
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.9
6.3
29
104
D46.0
ICD-10 Finland
Refractory anaemia without ring sideroblasts, so stated
+∞
6.3
6
*
WVA20
NOMESCO Finland
Medicine administration
3.2
6.3
24
77
L01BB05
ATC
fludarabine; systemic
27.1
6.2
8
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.8
6.2
104
639
JN3AD
NOMESCO Finland
Abdominal CT examination
2.0
6.2
71
385
E87.5
ICD-10 Finland
Hyperkalaemia
3.9
6.1
18
48
UJF30
NOMESCO Finland
Ileoscopy through colon
2.1
6.0
57
287
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
254
115
47.96
307.65
5.9
1.5
—
—
—
0
0
289
215
34.35
307.65
9.5
1.5
0.89
1.51
g/l
13.06
225
195
342
538
21.75
248.67
21.8
3.9
304.09
252.19
u/l
4.73
334
511
339
568
19.77
232.90
20.4
2.4
3.39
1.82
%
24.78
326
510
300
441
17.62
225.38
20.8
2.4
120.56
69.00
e9/l
22.05
247
325
112
21
70.13
202.07
5.4
1.1
—
—
—
0
0
112
21
70.13
202.07
5.4
1.1
—
—
—
0
0
107
31
44.65
174.32
3.1
1.5
—
—
—
0
0
134
82
22.63
166.26
1.5
1.6
—
—
—
0
0
227
330
12.58
165.43
5.2
2.8
9.81
10.54
g/l
0.76
216
306
204
269
12.81
159.35
2.9
1.7
1.98
1.48
g/l
0.89
187
245
147
163
12.77
127.86
2.4
3.7
54.99
91.23
mg/l
0.44
130
137
146
163
12.65
126.30
2.4
3.8
27.01
49.85
mg/l
0.91
129
137
106
83
16.29
114.09
6.1
6.2
797.36
130.18
iu/ml
0.89
28
11
131
146
12.14
112.75
2.3
3.5
8.30
2.90
ratio
0.43
82
86
199
393
8.15
106.63
3.1
3.2
66.10
66.40
g/l
0.17
192
359
136
187
9.90
99.30
2.6
2.3
5.67
7.49
g/l
25.18
131
170
136
187
9.90
99.30
2.6
2.3
3.89
4.19
g/l
2.36
131
170
136
187
9.90
99.30
2.6
2.3
3.16
3.82
g/l
2.11
131
170
131
174
10.12
98.24
2.7
2.3
2.72
3.07
g/l
2.97
126
157
118
163
9.39
85.09
2.8
2.5
1.37
0.66
g/l
0.73
107
141
247
781
5.66
76.46
3.8
2.6
16.29
12.69
umol/l
6.47
230
734
235
726
5.56
74.39
3.6
2.5
2.13
2.30
g/l
4.85
222
679
108
164
8.29
71.29
2.8
2.2
10.56
10.23
g/l
0.22
102
146
99
144
8.48
67.65
2.9
2.4
0.00
0.00
g/l
-0.00
92
129
220
689
5.19
67.31
3.6
2.6
30.89
21.98
%
8.68
209
646
70
68
11.96
64.82
1.3
1.2
271.29
280.87
u/ml
0.06
38
31
291
1179
4.98
63.26
2.8
2.3
4.11
3.00
mg/l
7.22
267
1020
173
495
4.99
57.90
5.6
3.0
12.09
8.79
umol/l
1.16
162
447
90
143
7.58
56.47
2.8
2.4
0.00
0.00
g/l
-0.00
81
122
222
827
4.25
51.53
2.2
1.6
1.87
2.61
g/l
6.49
181
477
58
62
10.56
49.96
1.3
1.3
149.17
177.41
au/ml
0.70
12
18
39
22
19.27
48.62
3.4
1.1
166.39
61.88
mg/l
2.17
33
16
54
59
10.23
45.69
14.9
1.8
33.85
32.64
pg
1.37
54
59
386
2277
5.27
43.98
23.4
6.7
19.86
11.84
umol/l
13.18
381
2167
393
2372
5.45
42.87
27.1
9.6
4.28
4.22
e9/l
0.05
362
2070
36
24
16.19
41.24
2.3
2.1
—
—
—
0
0
65
103
7.18
40.43
1.3
1.2
—
—
—
0
0
334
1860
3.89
39.15
5.0
3.0
526.22
131.33
ug/l
4.43
318
1718
60
93
7.27
38.02
1.2
1.4
—
—
—
0
0
238
1102
3.40
36.87
5.3
2.8
351.51
351.67
umol/l
0.01
230
952
57
90
7.09
35.45
1.2
1.1
—
6.44
—
0
7
335
1939
3.66
35.40
8.8
5.0
35.16
35.21
g/l
0.06
326
1813
52
81
7.11
32.69
1.4
1.2
59.50
24.65
u/l
1.50
44
72
74
163
5.22
32.57
3.5
2.0
19.13
7.87
iu/ml
0.55
22
44
159
613
3.43
32.50
8.0
5.5
1.10
1.05
mmol/l
1.05
152
561
38
11
37.49
30.14
1.5
1.3
—
—
—
0
0
324
1945
3.24
29.96
3.1
2.2
95.30
95.30
pmol/l
0.00
216
991
59
117
5.64
29.09
1.6
1.7
—
—
—
0
0
31
29
11.39
28.95
2.3
2.9
31.56
44.00
%
1.66
16
19
256
1369
2.96
28.79
2.6
1.8
24.20
20.73
nmol/l
1.20
237
1145
59
124
5.31
27.25
1.7
1.8
—
—
—
0
0
348
2255
3.22
26.63
14.4
7.5
1.21
1.21
mmol/l
0.33
318
1957
324
2054
2.94
25.09
12.2
6.7
1.21
1.21
mmol/l
0.29
310
1876
38
57
7.18
24.60
1.1
1.1
—
9.17
—
0
11
305
1910
2.76
23.51
8.2
2.9
—
—
estimate
—
0
0
172
815
2.77
23.21
2.1
1.7
1429.08
1184.47
nmol/l
1.55
137
600
28
31
9.55
23.19
1.2
1.1
—
—
—
0
0
50
108
5.07
22.29
6.9
3.3
0.87
0.87
nmol/l
0.00
13
85
167
801
2.70
21.76
2.9
2.0
—
—
—
0
0
198
1039
2.59
21.41
7.2
2.5
—
—
—
0
0
135
603
2.75
20.01
2.3
1.9
—
—
—
0
0
38
74
5.51
18.96
1.7
2.0
—
—
—
0
0
109
450
2.86
18.63
2.5
2.4
0.21
0.21
g/l
0.09
100
423
91
343
3.06
18.30
2.1
1.7
—
—
—
0
0
150
738
2.53
18.02
4.4
3.3
0.83
0.82
mmol/l
0.46
145
700
405
3130
3.42
18.01
22.0
8.6
84.04
81.30
u/l
0.73
396
2954
125
567
2.65
17.73
2.5
2.0
—
—
—
0
0
45
112
4.34
16.81
1.6
1.3
2.64
2.14
u/ml
—
10
20
44
109
4.36
16.54
1.5
1.6
—
—
—
0
0
101
426
2.76
16.42
2.0
2.0
379.23
389.47
nmol/l
0.20
96
397
275
1818
2.27
16.19
31.8
12.1
0.19
0.00
e9/l
0.55
232
1484
26
41
6.66
15.99
1.3
1.8
—
—
—
0
0
39
93
4.49
15.37
1.6
1.6
—
—
—
0
0
344
2529
2.42
15.31
9.1
5.4
7.05
6.74
mmol/l
1.34
327
2412
24
16
15.75
15.04
3.8
2.6
1474.75
1011.75
u/ml
0.58
24
16
30
59
5.37
14.78
1.4
1.2
2.27
1.53
u/ml
0.77
11
19
384
2992
2.70
14.66
7.9
4.5
24.13
13.00
mm/h
11.61
361
2766
218
1350
2.17
14.63
6.0
3.4
42.98
34.65
u/l
0.69
212
1283
106
483
2.55
14.63
7.1
3.6
1.18
1.89
mmol/l
1.07
92
401
31
65
5.04
14.22
1.5
1.1
5.46
3.48
u/ml
0.34
13
29
275
1886
2.14
13.90
3.4
2.5
77.68
78.02
nmol/l
0.07
258
1677
231
1492
2.10
13.59
3.7
3.3
1993.80
1475.43
ng/l
0.99
200
1289
244
1610
2.10
13.54
5.9
4.3
110.82
109.86
e6/l
0.01
191
1166
26
52
5.24
12.56
1.9
1.7
—
—
—
0
0
47
150
3.38
12.31
1.6
1.3
—
—
—
0
0
34
89
4.04
11.86
1.5
1.2
56.00
46.67
u/ml
—
7
12
26
55
4.95
11.80
1.9
1.7
—
—
—
0
0
290
2101
2.03
11.78
22.6
16.6
1.36
1.29
inr
1.02
258
1749
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
43
134
3.44
11.68
3.1
2.5
0.30
0.33
iu/ml
0.21
26
75
11
0
+∞
11.50
1.1
0.0
—
—
—
0
0
219
1448
1.98
11.48
5.1
3.6
49.15
106.19
e6/l
0.62
184
1130
22
41
5.58
11.46
1.3
1.9
—
—
—
0
0
22
41
5.58
11.46
1.3
1.9
—
—
—
0
0
22
41
5.58
11.46
1.2
1.3
—
—
—
0
0
22
41
5.58
11.46
1.3
1.9
—
—
—
0
0
71
299
2.62
11.36
2.2
1.7
—
—
—
0
0
21
38
5.74
11.27
1.2
1.2
—
—
—
0
0
19
15
13.15
11.23
1.3
2.5
42.31
41.78
g/l
0.13
19
15
23
46
5.21
11.11
1.5
2.3
—
—
—
0
0
24
50
5.01
11.08
1.5
2.2
—
—
—
0
0
21
39
5.59
10.97
1.2
1.2
—
—
—
0
0
195
1254
1.96
10.94
4.8
3.4
0.45
0.44
e6/l
0.00
157
936
157
940
2.02
10.79
3.0
1.7
3.12
1.48
mg/l
1.34
134
734
67
282
2.61
10.71
3.4
4.0
2.04
1.81
mmol/l
0.18
53
212
228
1554
1.92
10.69
3.8
3.5
2.32
2.35
mmol/l
2.80
207
1391
20
37
5.61
10.49
1.2
1.1
120.00
65.00
titre
—
6
6
244
1710
1.91
10.42
5.3
4.3
34.01
56.59
ng/l
0.63
197
1311
52
199
2.82
9.98
2.3
1.9
8.81
3.32
ug/l
0.49
47
177
164
1025
1.93
9.78
3.3
2.8
4.54
4.86
e6/l
0.08
149
941
77
361
2.36
9.75
5.3
3.8
92.88
84.22
ng/l
0.38
66
316
32
93
3.62
9.65
1.4
1.6
—
—
—
0
0
28
75
3.91
9.47
1.4
1.7
—
—
—
0
0
22
32
7.16
9.43
1.2
1.0
—
—
—
0
0
288
2178
1.86
9.22
5.8
4.4
0.05
0.70
estimate
0.47
64
438
201
1365
1.84
9.10
3.5
2.6
55.83
64.38
u/l
0.97
196
1273
284
2147
1.84
9.00
5.8
4.4
0.00
0.00
estimate
-0.00
67
454
286
2169
1.84
8.95
5.8
4.4
20.19
3.97
estimate
0.36
68
473
123
718
1.97
8.83
4.7
3.4
2.10
2.52
e6/l
0.30
75
364
20
44
4.71
8.67
2.2
2.2
—
—
—
0
0
128
770
1.92
8.36
4.4
3.2
1.47
1.05
e6/l
0.58
79
415
20
31
6.69
8.27
1.2
1.2
—
—
—
0
0
46
185
2.65
8.02
1.9
2.3
39.53
40.82
u/l
0.13
41
164
20
33
6.29
7.93
1.2
1.2
—
—
—
0
0
20
33
6.29
7.93
1.2
1.2
—
—
—
0
0
17
25
7.02
7.35
6.6
3.9
1.41
1.00
%
0.40
17
25
34
122
2.93
7.33
1.4
1.5
0.01
0.12
iu/ml
—
6
26
7
0
+∞
7.31
1.0
0.0
8.39
—
%
—
7
0
7
0
+∞
7.31
1.0
0.0
15.59
—
%
—
7
0
7
0
+∞
7.31
1.0
0.0
32.96
—
%
—
7
0
52
233
2.39
7.24
1.4
1.4
—
—
—
0
0
12
10
12.28
7.11
1.5
1.3
—
—
—
0
0
14
17
8.45
6.87
1.4
2.4
—
—
—
0
0
14
17
8.45
6.87
1.4
2.4
—
—
—
0
0
15
21
7.34
6.75
4.3
3.6
263.00
213.33
u/l
1.05
15
21
14
18
7.98
6.66
1.4
2.3
—
—
—
0
0
26
85
3.18
6.57
1.6
1.3
—
—
—
0
0
26
85
3.18
6.57
1.6
1.3
—
—
—
0
0
6
0
+∞
6.26
1.0
0.0
—
—
—
0
0
6
0
+∞
6.26
1.0
0.0
—
—
—
0
0
17
32
5.47
6.21
1.2
1.2
—
—
—
0
0
38
160
2.50
6.06
2.5
1.5
0.25
0.31
mg/l
—
7
70
308
2525
1.66
6.05
4.8
3.4
54.11
49.97
u/l
0.41
289
2359
12
15
8.18
5.87
2.2
2.1
0.68
0.59
mmol/l
2.22
12
15
38
165
2.42
5.68
2.5
3.2
—
—
—
0
0
114
739
1.72
5.57
1.4
1.3
57.88
33.20
iu/ml
0.79
38
237
14
24
5.98
5.57
1.4
2.1
—
—
—
0
0
14
24
5.98
5.57
1.4
2.1
—
—
—
0
0
14
24
5.98
5.57
1.4
2.1
—
—
—
0
0
14
24
5.98
5.57
1.4
2.1
—
—
—
0
0
10
10
10.19
5.55
1.0
1.5
—
—
—
0
0
139
953
1.66
5.50
3.7
3.0
2.45
2.46
mmol/l
0.40
126
849
423
3844
2.22
5.43
45.0
18.3
19.59
25.21
mg/l
5.42
383
3208
10
11
9.26
5.31
1.4
1.5
—
—
—
0
0
10
11
9.26
5.31
1.1
1.0
—
—
—
0
0
17
49
3.56
5.22
1.0
1.1
—
1.81
—
0
5
12
19
6.45
5.11
1.0
1.2
—
—
—
0
0
38
176
2.26
4.93
3.0
2.0
—
—
—
0
0
45
225
2.11
4.85
6.9
3.1
24.38
25.11
mmol/l
0.71
45
216
167
1228
1.56
4.85
5.7
4.4
0.00
0.01
estimate
0.78
61
424
28
114
2.55
4.81
1.3
1.4
—
—
—
0
0
15
36
4.27
4.55
1.1
1.2
—
94.40
—
0
5
8
8
10.15
4.53
1.9
1.3
83.88
87.13
%
—
8
8
32
143
2.33
4.52
1.4
1.3
—
—
—
0
0
101
668
1.66
4.51
1.3
1.3
17.46
11.91
u/ml
0.20
24
254
15
44
3.49
4.50
1.4
2.5
917.27
991.75
mg
0.06
15
44
60
342
1.87
4.48
3.4
2.9
52.74
61.93
ml/min/173m2
1.26
34
149
131
926
1.58
4.46
1.8
1.8
492.55
448.85
pmol/l
0.73
108
750
87
557
1.69
4.39
7.9
8.3
0.53
0.87
mmol/l
0.31
66
480
11
20
5.61
4.31
1.1
1.4
—
—
—
0
0
125
891
1.55
4.06
5.1
4.0
199.68
279.87
ng/l
0.36
104
736
177
1361
1.49
4.01
2.2
2.1
131.96
240.08
u/l
1.22
168
1285
49
272
1.90
3.97
6.6
2.7
1.63
1.15
%
2.23
49
272
28
126
2.30
3.92
1.4
1.6
—
—
—
0
0
64
388
1.75
3.91
2.3
2.6
5.21
6.82
ug/l
0.62
59
348
22
89
2.55
3.85
1.1
1.3
354.42
231.08
miu/ml
—
7
40
10
19
5.35
3.84
1.6
3.1
120.70
97.95
%
—
10
19
26
115
2.34
3.78
3.8
3.2
4.38
2.33
index
0.39
13
63
79
514
1.65
3.73
4.1
4.3
4.11
36.22
ug/l
1.31
69
434
19
73
2.67
3.68
1.3
1.3
—
—
—
0
0
6
6
10.11
3.50
1.2
1.3
—
—
—
0
0
6
6
10.11
3.50
1.2
1.2
—
—
—
0
0
423
3944
1.88
3.50
45.7
22.1
139.43
139.63
mmol/l
0.86
416
3863
14
47
3.04
3.44
1.6
1.2
—
—
—
0
0
127
939
1.49
3.41
1.4
1.3
2.67
2.05
u/ml
0.10
31
254
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
8
14
5.79
3.35
2.3
2.3
162.75
132.43
%
—
8
14
6
7
8.66
3.27
1.0
1.3
—
—
—
0
0
390
3575
1.59
3.23
6.5
5.5
2.04
1.96
mu/l
0.51
367
3235
422
3948
1.81
3.22
48.5
22.3
4.04
3.99
mmol/l
2.50
413
3857
425
4003
1.79
2.90
29.4
13.0
26.26
25.10
u/l
0.81
417
3868
9
22
4.15
2.89
1.1
1.1
—
—
—
0
0
254
2175
1.37
2.86
3.5
2.8
—
—
—
0
0
427
4030
1.81
2.85
52.3
24.2
86.09
80.32
umol/l
2.25
420
3976
31
167
1.92
2.79
2.6
1.8
—
—
—
0
0
9
23
3.97
2.78
2.0
1.9
—
—
—
0
0
10
29
3.50
2.70
1.9
1.8
—
—
—
0
0
11
35
3.19
2.66
2.3
1.8
—
—
—
0
0
183
1501
1.36
2.64
4.0
3.4
7.12
7.30
mmol/l
0.20
157
1250
334
3009
1.40
2.64
4.9
4.3
14.93
14.99
pmol/l
0.17
310
2708
9
25
3.65
2.58
1.9
1.3
—
—
—
0
0
9
25
3.65
2.58
1.9
1.3
—
—
—
0
0
9
26
3.51
2.49
2.0
1.8
—
—
—
0
0
30
170
1.82
2.35
2.4
1.9
523.57
504.63
ug/l
0.01
30
160
14
59
2.42
2.31
1.0
1.0
—
—
—
0
0
124
975
1.37
2.29
5.4
4.6
1.12
1.02
kg/l
0.49
85
672
8
23
3.52
2.28
1.3
1.1
—
—
—
0
0
15
66
2.32
2.27
7.6
6.3
14.63
12.11
mg/l
1.03
15
61
391
3658
1.45
2.20
40.4
18.0
73.73
76.41
ml/min/173m2
1.50
371
3411
8
24
3.37
2.19
1.4
1.7
91.38
79.71
umol/l
—
8
24
9
30
3.04
2.16
1.2
1.1
—
—
—
0
0
8
25
3.24
2.10
1.0
1.4
—
—
—
0
0
8
25
3.24
2.10
1.0
1.4
—
—
—
0
0
176
1476
1.31
2.08
5.4
4.2
16.50
10.04
mg/mmol
0.66
126
918
23
125
1.88
2.06
1.4
1.2
—
—
—
0
0
23
125
1.88
2.06
1.4
1.2
—
—
—
0
0
193
1649
1.29
1.96
6.3
4.3
0.09
0.04
estimate
0.37
58
383
18
92
2.00
1.92
4.6
2.9
8.00
9.64
pmol/l
0.35
18
92
12
54
2.25
1.75
1.1
1.1
—
20.36
—
0
11
22
125
1.80
1.75
1.3
1.3
—
—
—
0
0
427
4105
1.54
1.67
71.6
27.5
229.87
246.64
e9/l
3.79
417
4029
6
19
3.19
1.66
2.2
1.3
—
—
—
0
0
6
19
3.19
1.66
2.2
1.3
—
—
—
0
0
427
4108
1.53
1.62
71.3
27.5
3.87
4.44
e12/l
42.06
417
4015
427
4108
1.53
1.62
71.2
27.4
94.86
91.32
fl
21.02
422
4060
427
4108
1.53
1.62
72.2
28.0
35.84
39.91
%
35.39
422
4057
12
56
2.17
1.62
1.2
1.1
—
—
—
0
0
8
33
2.45
1.54
1.3
1.2
113.88
103.00
pmol/l
—
8
33
15
81
1.88
1.41
2.1
1.5
—
—
—
0
0
22
135
1.66
1.38
1.7
1.5
—
—
—
0
0
6
23
2.63
1.37
3.0
1.6
133.58
77.67
ng/l
—
6
23
5
17
2.96
1.36
1.8
3.8
4.82
4.70
kpa
—
5
17
5
17
2.96
1.36
1.8
3.8
7.96
10.21
kpa
—
5
17
5
17
2.96
1.36
1.0
1.2
98.56
207.58
iu/ml
—
5
17
10
47
2.15
1.34
5.4
2.8
11.20
13.13
index
—
5
31
12
62
1.96
1.29
1.8
3.0
1.18
1.20
mmol/l
0.29
12
62
12
62
1.96
1.29
1.8
3.0
103.75
105.68
mmol/l
0.75
12
62
12
62
1.96
1.29
1.8
3.0
4.09
4.06
mmol/l
0.12
12
62
9
45
2.02
1.24
1.3
1.2
—
—
—
0
0
57
438
1.34
1.23
5.4
3.6
—
—
—
0
0
5
19
2.65
1.22
2.2
1.7
56.00
64.24
ug/l
—
5
19
36
257
1.43
1.20
1.4
1.2
287.68
221.52
u/ml
0.20
25
234
27
182
1.51
1.18
1.4
1.3
—
—
—
0
0
388
3713
1.28
1.17
5.8
5.5
6.21
6.03
mmol/l
1.15
358
3366
8
39
2.07
1.16
1.4
2.2
35.85
4.84
umol/l
—
8
30
11
58
1.92
1.13
1.8
1.5
—
—
—
0
0
11
59
1.89
1.08
1.8
1.5
—
—
—
0
0
11
59
1.89
1.08
1.8
1.5
—
—
—
0
0
11
61
1.82
0.99
1.8
1.5
—
—
—
0
0
134
1177
1.20
0.96
6.5
3.8
0.00
0.07
estimate
0.52
50
362
11
62
1.79
0.95
1.8
1.5
—
—
—
0
0
11
62
1.79
0.95
1.8
1.5
—
—
—
0
0
61
494
1.27
0.94
11.8
8.0
—
—
—
0
0
9
52
1.75
0.93
2.7
4.8
—
—
—
0
0
13
80
1.64
0.85
1.6
1.9
3.83
4.55
mmol/24h
0.58
13
69
11
65
1.71
0.83
1.3
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.0
—
1.02
—
0
17
0
24
0.00
0.79
0.0
1.0
—
—
—
0
0
15
98
1.55
0.79
2.3
1.6
—
—
—
0
0
0
28
0.00
0.76
0.0
2.0
—
—
—
0
0
27
201
1.36
0.76
2.6
3.0
19.30
58.37
u/ml
1.28
27
195
7
40
1.76
0.71
1.9
1.3
—
—
—
0
0
56
471
1.22
0.65
1.8
1.4
—
—
—
0
0
15
105
1.44
0.60
2.6
1.9
518.97
4.45
iu/l
—
6
42
0
20
0.00
0.60
0.0
1.8
—
—
—
0
0
41
347
1.20
0.47
1.2
1.5
—
—
—
0
0
15
111
1.36
0.47
2.3
2.4
98.79
81.37
ug/min
—
8
63
5
31
1.62
0.43
3.4
2.9
1.20
0.84
index
—
5
31
98
1069
0.89
0.42
4.3
4.9
24.17
21.97
%
0.70
54
548
5
33
1.52
0.41
17.0
2.2
14.80
13.33
%
—
5
33
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
72
790
0.89
0.35
3.0
3.3
1.17
0.82
ug/l
0.88
55
527
6
43
1.40
0.35
1.0
1.1
3.11
1.71
nmol/l
—
6
38
7
52
1.35
0.31
1.1
1.3
—
—
—
0
0
7
57
1.23
0.29
1.3
1.4
0.51
33.28
nmol/l
—
7
52
156
1630
0.94
0.26
2.0
2.0
1.47
1.31
mmol/l
1.29
126
1347
12
96
1.26
0.24
1.5
1.4
—
—
—
0
0
54
587
0.91
0.24
1.5
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.0
—
2.74
—
0
5
30
333
0.89
0.20
2.4
2.3
9.91
13.40
nmol/l
1.11
25
300
21
239
0.87
0.20
1.3
2.0
—
—
—
0
0
369
3645
1.06
0.18
8.0
7.0
37.24
39.96
mmol/mol
5.09
341
3382
368
3723
0.94
0.17
5.7
5.3
1.38
1.46
mmol/l
3.27
336
3384
7
89
0.78
0.14
1.1
1.1
1.49
1.58
g/l
—
7
89
22
199
1.11
0.13
1.0
1.1
—
—
—
0
0
24
261
0.92
0.12
1.5
2.1
—
—
—
0
0
378
3810
0.96
0.11
6.5
6.2
2.41
2.62
mmol/l
4.79
347
3483
354
3566
0.97
0.08
5.1
4.5
1.37
1.27
mmol/l
1.28
323
3210
137
1343
1.03
0.08
4.9
5.9
2.45
2.53
ug/l
0.07
124
1192
7
68
1.03
0.08
2.1
1.9
—
—
—
0
0
55
531
1.04
0.07
5.2
5.1
31.34
32.29
%
0.20
38
328
11
122
0.90
0.07
1.5
1.9
—
—
—
0
0
13
141
0.92
0.05
1.8
2.0
—
—
—
0
0
25
238
1.05
0.05
1.6
1.3
22.05
167.08
u/ml
—
8
90
10
94
1.07
0.01
1.4
1.1
0.93
0.88
g/l
—
10
94
11
116
0.95
0.00
1.5
1.8
59.55
42.25
nmol/l
0.91
11
110
374
3742
1.00
0.00
5.8
5.4
4.28
4.53
mmol/l
4.64
343
3431
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
8
80
1.00
-0.00
2.0
2.8
36.88
30.41
u/ml
—
8
80
0
7
0.00
-0.00
0.0
1.6
—
77.29
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
446.86
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.6
—
10.24
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
40.78
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_AIHA_OTHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_AIHA_OTHER | 2.299 [1.91, 2.77] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.982 |
During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 1170 females with D3_AIHA_OTHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_AIHA_OTHER | 2.82 [2.2, 3.62] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 421 out of 976 males with D3_AIHA_OTHER died.
Mortality risk
Mortality risk for people of age
years, who have D3_AIHA_OTHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.296% | 0.505% |
| 5 | 1.48% | 3.21% |
| 10 | 3.848% | 8.18% |
| 15 | 7.384% | 13.968% |
| 20 | 13.26% | 22.862% |
Relationships between endpoints
↥Index endpoint: D3_AIHA_OTHER – Other autoimmune haemolytic anaemias
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data