hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.
Other and unspecified acquired haemolytic anaemias
DOID EFO Endpoint Browser PheWeb
D3_ACQHAEMOLYTICANAEMIANAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
405 |
4. Check minimum number of eventsNone |
405 |
5. Include endpointsNone |
405 |
6. Filter based on genotype QC (FinnGen only) |
348 |
Control definitions (FinnGen only)
- Control exclude
- D3_HAEMOLYTICANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified acquired haemolytic anaemias
based on the number of shared cases.
Similar with more cases:
- Acquired haemolytic anaemia
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3078 | 1682 | 1353 |
| Only index persons | 1978 | 1086 | 892 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 66.16 | 67.62 | 64.26 |
| Only index persons | 61.66 | 62.26 | 60.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 348 | 162 | 186 |
| Unadjusted period prevalence (%) | 0.07 | 0.06 | 0.09 |
| Median age at first event (years) | 63.17 | 57.31 | 68.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 361
- Matched controls
- 3610
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
307.7
277
*
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
99.7
91
*
D64.9
ICD-10 Finland
Anaemia, unspecified
9.5
96.3
156
268
XW000
NOMESCO Finland
Bone marrow biopsy
12.4
69.7
76
76
D59.8
ICD-10 Finland
Other acquired haemolytic anaemias
+∞
65.7
61
*
WW500
NOMESCO Finland
Blood transfusion
9.0
45.2
61
80
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
13.8
43.4
42
34
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.0
39.4
108
285
D64.8
ICD-10 Finland
Other specified anaemias
12.9
33.0
33
28
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.5
29.9
170
734
ZX120
NOMESCO Finland
Intravenous
4.6
27.3
76
199
2839X
ICD-9 Finland
Acquired haemolytic anaemias, Acquired haemolytic anaemia, unspecified
+∞
26.4
25
*
B01AA03
ATC
warfarin; systemic
3.4
25.9
129
505
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.7
25.3
67
168
L04AX01
ATC
azathioprine; systemic
7.3
25.2
39
59
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
10.1
24.7
29
31
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
7.2
24.3
38
58
I35.0
ICD-10 Finland
Aortic (valve) stenosis
5.0
24.2
58
134
R50.9
ICD-10 Finland
Fever, unspecified
3.5
22.3
96
339
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
4.8
21.5
53
125
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
21.4
123
516
B03XA02
ATC
darbepoetin alfa; parenteral
9.3
20.9
26
30
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
8.8
20.8
27
33
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.1
20.5
64
181
H02AB06
ATC
prednisolone; systemic
2.8
20.3
222
1303
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
20.0
19
*
C03CA01
ATC
furosemide; systemic
2.7
18.7
176
945
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
17.9
101
415
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
17.8
169
906
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
16.4
217
1345
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
16.0
143
738
UJF32
NOMESCO Finland
Coloscopy
2.6
15.8
130
643
TK800
NOMESCO Finland
Hemodialysis
7.4
15.4
23
33
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.7
15.0
102
458
B03BA03
ATC
hydroxocobalamin; parenteral
4.2
14.8
42
110
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.0
14.4
43
117
M04AA01
ATC
allopurinol; systemic
2.9
14.0
77
308
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
18.5
14.0
21
12
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
5.8
13.7
26
48
L04AA06
ATC
mycophenolic acid; systemic
10.7
13.7
26
26
ZXD05
NOMESCO Finland
Urgent procedure
2.4
13.7
134
711
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
6.4
13.6
23
38
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
4.4
13.1
34
83
H02AB07
ATC
prednisone; oral
2.9
12.9
70
277
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
14.8
12.9
21
15
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
12.9
12.8
22
18
WX872
NOMESCO Finland
Intensive care
4.1
12.7
36
94
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.8
12.5
41
119
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.6
12.5
43
129
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.6
12.5
31
73
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.5
12.3
46
146
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.3
12.0
116
606
A02BC02
ATC
pantoprazole; systemic
2.4
11.7
268
1979
28398
ICD-8 Finland
Acquired haemolytic anaemias, Aliae definitar
+∞
11.5
11
*
D59.0
ICD-10 Finland
Drug-induced autoimmune haemolytic anaemia
+∞
11.5
11
*
I34.1
ICD-10 Finland
Mitral (valve) prolapse
5.2
11.4
24
49
GD1AD
NOMESCO Finland
Thorax CT examination
3.5
11.2
41
128
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
10.5
11.2
21
21
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
6.0
11.1
20
35
B01AB05
ATC
enoxaparin; parenteral
2.2
11.0
138
798
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
4.0
11.0
32
85
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
11.0
102
521
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
18.5
10.8
16
9
3AC01, ,
NOMESCO Finland
18.5
10.8
16
9
B80
ICPC
Iron deficiency anaemia
5.7
10.5
20
37
B82
ICPC
Anaemia other/unspecified
4.7
10.2
24
54
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.0
9.8
29
78
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
13.9
9.8
16
12
L04AD02
ATC
tacrolimus; systemic
15.6
9.6
15
10
TGC00
NOMESCO Finland
Bronchial lavation
4.6
9.5
23
53
B03XA01
ATC
erythropoietin; parenteral
12.8
9.4
16
13
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.6
9.4
32
95
127
Kela drug reimbursment
Transplant complication
11.1
9.4
17
16
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.8
9.3
29
81
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
9.3
77
372
C03DA01
ATC
spironolactone; oral
2.5
9.2
66
299
K83
ICPC
Heart valve disease NOS
11.9
9.2
16
14
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
9.1
61
267
I50.0
ICD-10 Finland
Congestive heart failure
2.8
9.1
49
192
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
9.1
95
506
JN4BD
NOMESCO Finland
Extensive body CT
2.7
8.8
51
208
I50.9
ICD-10 Finland
Heart failure, unspecified
2.2
8.7
84
432
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
10.4
8.6
16
16
B81
ICPC
Anaemia vit B12/folate deficiency
3.9
8.5
25
67
K78
ICPC
Atrial fibrillation/flutter
2.8
8.5
45
175
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
8.9
8.4
17
20
D50.8
ICD-10 Finland
Other iron deficiency anaemias
9.8
8.4
16
17
A11CC03
ATC
alfacalcidol; systemic
4.9
8.2
18
38
JMA10
NOMESCO Finland
Transabdominal total splenectomy
17.7
8.1
12
7
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
17.7
8.1
12
7
D70.89
ICD-10 Finland
Neutropenic splenomegaly
9.2
8.1
16
18
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
34.2
8.1
10
*
JN3AD
NOMESCO Finland
Abdominal CT examination
2.4
8.0
60
276
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
8.0
49
205
ZXE20
NOMESCO Finland
More than three and less than five hours
2.3
8.0
65
311
Z94.0
ICD-10 Finland
Kidney transplant status
13.4
7.9
13
10
C01BD01
ATC
amiodarone; systemic
4.4
7.8
20
48
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
3.2
7.8
31
102
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.4
7.8
57
260
TPH07
NOMESCO Finland
Cathetrisation of artery
2.4
7.7
55
247
UJF92
NOMESCO Finland
Capsular endoscopy
7.0
7.7
18
27
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.8
7.6
23
63
TFP20
NOMESCO Finland
Cardiodefibrillation
2.8
7.5
40
156
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
81.7
7.4
8
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
7.3
68
343
28390
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria primaria
+∞
7.3
7
*
FKC50
NOMESCO Finland
Repair of mitral valve for insufficiency using prosthetic chord
16.1
7.3
11
7
A12AA04
ATC
calcium carbonate; oral
8.2
7.2
15
19
K92.1
ICD-10 Finland
Melaena
3.0
7.2
32
113
M05BA04
ATC
alendronic acid; oral
2.6
7.1
42
173
A06AD11
ATC
lactulose; oral
2.2
7.0
69
356
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
14.1
6.9
11
8
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.9
6.9
20
53
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
6.3
6.9
17
28
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
6.9
135
886
PJA10
NOMESCO Finland
Exploration of lymph nodes
9.6
6.8
13
14
K84
ICPC
Heart disease other
4.4
6.8
17
40
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
6.8
54
255
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
17.1
6.8
10
6
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.9
6.7
32
117
1XC02, ,
NOMESCO Finland
23.0
6.7
9
*
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
4.2
6.7
18
45
C01AA05
ATC
digoxin; systemic
2.4
6.6
46
204
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.0
6.6
29
101
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
5.5
6.6
18
34
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
6.4
6.5
16
26
H03AA01
ATC
levothyroxine sodium; systemic
2.0
6.5
84
479
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.9
6.4
100
607
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
14.6
6.4
10
7
WX892
NOMESCO Finland
Monitored bed care
2.7
6.4
35
138
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.4
6.4
23
71
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
6.3
101
618
D59.5
ICD-10 Finland
Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
+∞
6.3
6
*
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
27.2
6.3
8
*
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
27.2
6.3
8
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
6.2
150
1040
I50.1
ICD-10 Finland
Left ventricular failure
2.9
6.2
30
111
Z49.1
ICD-10 Finland
Extracorporeal dialysis
7.9
6.2
13
17
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
6.2
102
631
WX882
NOMESCO Finland
High dependency care
4.2
6.2
16
39
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.7
6.1
19
53
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
10.3
6.1
11
11
A10AB05
ATC
insulin aspart; parenteral
2.5
6.0
40
174
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
184
157
22.86
197.60
6.9
1.7
0.74
1.50
g/l
13.38
118
140
137
76
28.44
180.41
3.6
1.6
—
—
—
0
0
213
391
11.85
128.90
16.6
4.0
432.98
241.51
u/l
10.22
201
373
217
425
11.29
123.56
14.6
2.6
3.49
1.79
%
17.23
207
383
188
325
10.98
118.17
15.5
2.4
118.47
70.10
e9/l
14.97
155
239
46
12
43.79
75.76
3.2
1.2
—
—
—
0
0
46
12
43.79
75.76
3.2
1.2
—
—
—
0
0
68
61
13.50
66.82
8.1
6.5
237.30
145.83
iu/ml
—
20
6
182
533
5.87
62.15
5.3
2.5
2.21
2.29
g/l
0.96
174
494
182
573
5.39
56.04
5.6
2.6
14.78
12.80
umol/l
1.84
176
532
116
266
5.95
50.93
4.3
2.5
10.20
10.50
g/l
0.14
110
243
76
120
7.76
48.19
3.2
2.8
63.28
110.76
mg/l
0.40
60
103
76
120
7.76
48.19
3.2
2.8
27.70
53.54
mg/l
0.82
60
103
113
277
5.48
45.60
3.0
2.3
65.28
66.15
g/l
0.39
106
259
70
109
7.73
44.80
2.9
2.5
13.98
3.27
ratio
0.42
41
55
210
848
4.53
44.72
4.9
2.2
4.13
2.91
mg/l
4.22
198
736
125
374
4.58
38.94
6.0
2.9
14.28
8.35
umol/l
1.52
117
332
35
26
14.80
37.89
3.5
1.3
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
53
88
6.89
31.60
5.8
3.2
0.32
0.36
iu/ml
0.33
34
52
38
44
9.53
30.70
13.6
1.6
33.92
32.11
pg
2.26
38
44
41
57
7.99
28.59
1.7
1.4
152.77
143.78
au/ml
0.15
13
16
64
142
5.26
28.12
3.0
1.7
3.85
4.24
g/l
1.92
59
132
64
142
5.26
28.12
3.0
1.7
5.61
7.32
g/l
11.31
59
132
64
142
5.26
28.12
3.0
1.7
3.35
3.83
g/l
0.78
59
132
40
56
7.91
27.71
1.4
1.2
267.50
220.31
u/ml
0.41
27
32
61
136
5.19
26.59
3.1
1.7
2.92
2.97
g/l
0.14
56
126
58
125
5.34
26.27
3.1
1.9
0.48
0.60
g/l
0.13
49
112
30
6
54.28
25.66
1.6
1.2
—
—
—
0
0
243
1401
3.25
24.73
7.9
3.1
408.74
125.05
ug/l
6.57
234
1303
116
438
3.43
24.50
15.7
6.0
1.12
1.05
mmol/l
1.03
110
404
138
582
3.22
24.25
2.4
1.7
1558.37
1195.07
nmol/l
2.53
114
441
55
123
5.10
23.80
2.8
1.7
9.89
10.35
g/l
0.25
50
112
136
577
3.18
23.55
2.9
1.9
—
—
—
0
0
239
1425
3.00
21.77
11.9
4.9
34.74
35.45
g/l
1.04
227
1341
270
1758
3.13
20.27
22.7
9.7
4.51
4.19
e9/l
0.24
250
1544
261
1669
3.04
20.23
21.8
6.5
20.47
11.87
umol/l
9.70
256
1584
123
541
2.93
19.41
6.9
3.6
0.80
0.82
mmol/l
0.56
118
513
180
965
2.73
19.40
2.5
1.7
23.77
20.65
nmol/l
0.55
164
811
47
110
4.76
19.16
3.0
1.7
0.00
0.00
g/l
-0.00
40
101
43
95
5.00
18.76
2.8
1.7
—
—
—
0
0
101
406
3.07
18.64
2.7
1.9
—
—
—
0
0
105
434
3.00
18.43
2.5
1.8
—
—
—
0
0
41
90
5.01
18.00
2.7
1.7
—
—
—
0
0
36
71
5.52
17.81
2.0
1.7
—
—
—
0
0
45
109
4.57
17.56
3.0
1.7
0.00
0.00
g/l
-0.00
37
95
230
1439
2.65
17.47
17.3
7.2
1.20
1.21
mmol/l
1.31
222
1327
42
100
4.62
16.72
3.2
1.7
0.00
0.00
g/l
-0.00
37
95
245
1601
2.65
16.67
20.1
7.6
1.20
1.21
mmol/l
1.29
216
1396
133
660
2.61
16.13
2.2
1.4
2.28
2.64
g/l
1.18
100
391
151
800
2.53
15.92
4.8
2.9
369.78
353.46
umol/l
1.01
133
696
224
1433
2.48
15.46
8.2
2.8
—
—
estimate
—
0
0
233
1523
2.49
15.25
44.2
15.2
1.57
1.28
inr
7.73
208
1279
217
1387
2.42
14.73
3.1
2.2
95.80
96.36
pmol/l
0.05
130
727
41
111
4.04
13.79
7.9
3.7
1.94
1.53
mg/l
2.07
41
95
45
136
3.64
12.94
3.1
2.2
20.11
8.25
iu/ml
0.75
14
34
32
76
4.52
12.73
6.3
3.0
32.38
35.63
umol/l
0.30
32
66
138
762
2.31
12.68
7.3
2.5
—
—
—
0
0
169
1018
2.24
12.56
7.1
3.4
42.94
32.58
u/l
2.13
159
962
35
92
4.11
12.22
1.7
1.4
—
—
—
0
0
29
66
4.69
12.14
2.1
1.6
—
—
—
0
0
135
754
2.26
11.93
4.4
2.9
4.67
4.94
e6/l
0.10
123
693
164
993
2.19
11.86
4.6
2.6
67.41
66.02
u/l
0.06
159
917
61
239
2.87
11.41
2.4
1.7
—
—
—
0
0
16
8
20.84
11.23
3.8
1.3
1263.94
1115.13
u/ml
—
16
8
167
1044
2.12
10.87
6.2
3.3
2207.77
1554.62
ng/l
1.27
146
891
170
1071
2.11
10.83
5.9
3.6
29.71
111.52
e6/l
0.75
146
827
22
45
5.14
10.40
1.3
1.2
1.69
1.33
u/ml
0.64
13
18
22
45
5.14
10.40
2.7
1.7
—
—
—
0
0
23
49
4.95
10.39
1.5
1.2
4.20
3.67
u/ml
0.09
15
24
255
1890
2.19
10.36
12.4
5.5
6.71
6.71
mmol/l
0.00
242
1798
29
75
4.12
10.34
3.7
3.3
0.67
0.92
nmol/l
0.99
13
64
26
62
4.44
10.28
2.7
1.9
—
—
—
0
0
22
48
4.82
9.67
2.3
1.9
—
—
—
0
0
25
61
4.33
9.60
2.2
1.7
—
—
—
0
0
32
95
3.60
9.42
1.9
1.4
—
—
—
0
0
60
257
2.60
9.38
7.5
4.1
124.33
89.45
ng/l
1.10
52
223
167
1086
2.00
9.38
4.6
3.4
2.32
2.35
mmol/l
2.32
153
983
36
116
3.34
9.35
3.7
3.1
—
—
—
0
0
146
906
2.03
9.35
5.9
3.5
0.54
0.42
e6/l
0.22
123
665
15
11
14.16
9.26
4.2
1.9
0.64
0.60
mmol/l
0.78
15
11
21
46
4.79
9.18
2.7
1.8
—
—
—
0
0
80
396
2.31
9.13
12.4
9.4
1.16
0.88
mmol/l
0.27
67
338
80
400
2.28
8.90
12.4
9.3
11.95
12.04
kpa
0.06
75
388
20
30
6.99
8.48
2.0
1.9
—
—
—
0
0
49
206
2.60
7.92
4.4
3.3
1.62
1.79
mmol/l
0.08
39
154
49
206
2.60
7.92
2.0
1.7
—
—
—
0
0
192
1363
1.87
7.85
3.6
2.6
72.74
76.01
nmol/l
1.01
178
1216
109
643
2.00
7.81
7.2
3.9
244.49
317.86
ng/l
0.21
97
508
18
40
4.68
7.73
2.3
1.9
—
—
—
0
0
54
241
2.46
7.71
4.5
2.9
58.45
66.10
ml/min/173m2
0.57
29
100
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
13
11
12.21
7.63
4.4
2.0
126.16
141.82
%
0.23
13
11
15
18
8.64
7.39
2.7
2.1
—
—
—
0
0
7
0
+∞
7.31
1.1
0.0
—
—
—
0
0
92
526
2.01
7.12
5.2
3.3
3.33
2.07
e6/l
0.54
65
264
19
48
4.12
6.98
1.1
1.4
—
—
—
0
0
14
17
8.52
6.89
3.7
2.2
89.43
96.94
%
0.33
14
17
115
718
1.88
6.83
4.5
1.8
2.11
1.46
mg/l
0.38
97
571
25
78
3.37
6.83
1.8
1.5
—
—
—
0
0
9
5
18.41
6.29
1.9
1.0
102.33
88.20
%
—
9
5
280
2320
1.92
6.26
22.7
8.3
85.93
80.75
u/l
1.15
275
2181
94
565
1.90
6.21
4.5
3.2
1.27
0.94
e6/l
0.47
68
302
63
332
2.09
6.03
14.7
4.0
1.19
1.80
mmol/l
0.61
54
280
60
312
2.11
5.94
4.5
2.5
43.04
33.75
u/l
0.69
53
253
29
108
2.83
5.91
1.8
1.3
—
—
—
0
0
271
2241
1.84
5.85
8.0
4.4
21.85
12.52
mm/h
8.27
260
2074
20
60
3.47
5.81
1.5
1.3
—
—
—
0
0
20
60
3.47
5.81
1.5
1.3
—
—
—
0
0
21
67
3.27
5.56
1.3
1.1
—
3.53
—
0
7
37
162
2.43
5.49
1.9
1.5
—
—
—
0
0
141
991
1.69
5.37
2.9
2.2
139.60
213.06
u/l
2.17
136
944
24
86
2.92
5.25
3.1
3.6
7.38
2.24
index
—
8
50
248
2029
1.71
5.21
7.4
5.1
34.86
2046.20
e6/l
—
7
46
10
12
8.53
5.09
1.5
1.3
—
—
—
0
0
9
9
10.22
5.05
1.2
1.3
—
—
—
0
0
21
73
2.99
4.85
1.4
1.4
—
—
—
0
0
8
7
11.65
4.80
1.1
1.0
—
—
—
0
0
102
674
1.72
4.79
2.4
1.8
492.52
20781975.62
pmol/l
0.50
82
563
207
1639
1.62
4.73
5.7
4.2
37.59
5.40
estimate
0.59
56
348
7
5
14.24
4.59
8.6
9.4
—
—
—
0
0
15
36
4.30
4.57
1.9
1.3
15962.50
36662.89
e6/l
—
8
18
13
27
4.95
4.54
1.4
1.3
—
—
—
0
0
14
32
4.51
4.48
1.4
1.2
—
—
—
0
0
21
77
2.83
4.43
1.4
1.3
—
—
—
0
0
13
28
4.78
4.41
1.4
1.3
—
—
—
0
0
13
28
4.78
4.41
1.4
1.3
—
—
—
0
0
76
472
1.77
4.40
15.1
7.5
104.68
103.95
mmol/l
0.63
76
472
12
26
4.74
4.09
1.1
1.2
—
—
—
0
0
14
36
4.00
4.04
1.4
1.2
—
—
—
0
0
12
27
4.56
3.97
1.3
1.2
—
—
—
0
0
14
37
3.89
3.94
2.7
1.9
88.33
88.74
%
0.10
14
37
14
38
3.79
3.84
2.7
1.9
—
—
—
0
0
200
1620
1.53
3.79
5.8
4.1
0.00
0.00
estimate
-0.00
53
337
202
1648
1.51
3.64
5.8
4.2
0.00
0.94
estimate
0.51
49
324
19
75
2.62
3.52
1.5
1.4
—
—
—
0
0
6
6
10.14
3.51
11.3
9.7
5.05
5.90
mmol/l
—
6
6
10
22
4.64
3.45
2.5
2.0
—
—
—
0
0
9
18
5.10
3.39
2.7
2.1
—
—
—
0
0
8
14
5.82
3.36
2.9
1.7
—
—
—
0
0
8
14
5.82
3.36
2.9
1.7
—
—
—
0
0
160
1260
1.48
3.34
6.4
4.1
38.40
37.29
ng/l
0.06
133
929
54
330
1.75
3.29
6.6
3.4
—
—
—
0
0
22
97
2.35
3.26
1.4
1.4
—
—
—
0
0
11
29
3.88
3.21
2.5
2.3
—
—
—
0
0
8
15
5.43
3.21
3.0
4.3
278.88
218.93
u/l
—
8
15
8
15
5.43
3.21
2.9
1.7
—
—
—
0
0
9
20
4.59
3.13
2.7
2.0
—
—
—
0
0
94
670
1.54
3.12
2.8
2.9
2.44
2.46
mmol/l
0.44
81
597
5
5
10.11
2.98
1.4
1.6
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
5
5
10.11
2.98
1.0
1.0
78.00
—
%
—
5
0
5
5
10.11
2.98
1.0
1.0
102.40
111.00
%
—
5
5
12
37
3.32
2.96
1.4
1.1
—
—
—
0
0
8
18
4.52
2.81
1.1
1.2
—
—
—
0
0
8
18
4.52
2.81
1.0
1.2
—
—
—
0
0
26
132
2.04
2.78
3.6
1.9
—
—
—
0
0
10
29
3.52
2.71
3.1
1.8
—
—
—
0
0
98
725
1.48
2.70
5.2
4.3
1.02
1.02
kg/l
0.60
74
495
8
19
4.28
2.69
2.9
1.6
—
—
—
0
0
8
19
4.28
2.69
2.9
1.6
—
—
—
0
0
8
19
4.28
2.69
2.9
1.6
—
—
—
0
0
8
19
4.28
2.69
2.9
1.6
—
—
—
0
0
134
1054
1.43
2.68
5.2
4.2
15.62
9.38
mg/mmol
1.05
95
671
11
35
3.21
2.66
1.2
1.1
—
—
—
0
0
12
44
2.79
2.57
1.1
1.0
—
—
—
0
0
5
7
7.22
2.55
1.8
1.4
—
—
—
0
0
75
532
1.52
2.52
1.4
1.3
49.38
32.64
iu/ml
0.49
21
164
46
693
0.61
2.47
2.9
3.1
0.61
0.83
ug/l
1.51
36
446
53
350
1.60
2.43
3.1
4.3
3.03
41.25
ug/l
1.03
44
290
68
477
1.52
2.40
1.4
1.3
101.82
10.10
u/ml
0.43
19
182
204
1748
1.38
2.39
3.4
2.9
—
—
—
0
0
10
33
3.09
2.37
2.5
1.5
—
—
—
0
0
10
33
3.09
2.37
2.5
1.5
—
—
—
0
0
10
33
3.09
2.37
2.5
1.5
—
—
—
0
0
7
17
4.18
2.37
2.4
4.3
1.07
0.88
%
—
7
17
6
13
4.67
2.28
5.0
1.6
44.58
41.45
g/l
—
6
13
24
128
1.94
2.27
2.5
1.7
—
—
—
0
0
20
100
2.06
2.25
1.6
1.7
—
—
—
0
0
10
35
2.91
2.22
1.2
1.3
—
—
—
0
0
5
9
5.61
2.22
1.2
1.2
—
—
—
0
0
115
908
1.39
2.18
5.7
4.3
0.04
0.02
estimate
0.27
45
311
51
343
1.57
2.17
2.2
1.9
1.43
1.55
%
0.86
42
299
46
302
1.60
2.17
3.7
2.7
0.20
0.45
e6/l
1.00
46
289
9
30
3.05
2.16
1.4
1.2
—
—
—
0
0
7
19
3.74
2.16
1.3
1.1
—
—
—
0
0
114
900
1.39
2.16
5.1
3.6
0.00
0.10
estimate
0.58
40
273
134
1094
1.36
2.04
4.4
3.4
6.55
7.67
mmol/l
2.33
114
916
149
1237
1.35
2.04
5.4
4.1
0.02
0.04
estimate
0.29
44
280
7
21
3.38
1.97
1.6
1.4
—
—
—
0
0
7
21
3.38
1.97
1.6
1.4
—
—
—
0
0
91
709
1.38
1.84
1.3
1.3
1.57
1.72
u/ml
0.05
19
189
5
12
4.21
1.83
2.0
4.2
8.76
9.68
kpa
—
5
12
5
12
4.21
1.83
2.0
4.2
5.02
4.53
kpa
—
5
12
7
23
3.08
1.80
1.3
1.3
—
—
—
0
0
8
29
2.80
1.80
2.3
1.9
464.50
864.86
mg
—
8
29
7
24
2.95
1.73
5.3
2.8
1.14
0.88
index
—
7
24
7
25
2.83
1.65
1.0
1.0
—
—
—
0
0
7
25
2.83
1.65
1.0
1.2
125.71
107.32
pmol/l
—
7
25
10
41
2.48
1.65
2.7
4.0
—
—
—
0
0
20
113
1.82
1.64
1.4
1.6
60.00
12.35
u/ml
—
5
17
217
1945
1.29
1.57
7.6
3.4
63.97
49.92
u/l
1.73
206
1829
10
44
2.31
1.57
1.0
1.2
—
—
—
0
0
18
101
1.82
1.52
1.4
1.4
0.01
0.03
iu/ml
—
5
19
245
2237
1.30
1.50
5.1
4.2
15.09
14.89
pmol/l
0.56
220
2028
74
931
0.74
1.49
4.6
4.8
21.40
21.80
%
0.10
36
469
5
16
3.15
1.44
2.6
1.8
101.60
72.47
ng/l
—
5
16
13
67
1.98
1.40
8.5
2.5
13.12
8.22
pmol/l
0.68
13
67
9
41
2.23
1.38
3.1
2.1
4.01
10.42
umol/l
—
9
30
6
24
2.52
1.31
3.0
2.7
499.17
566.08
ml
—
6
12
16
92
1.77
1.27
1.5
1.4
—
—
—
0
0
23
147
1.60
1.26
2.8
3.4
619.57
1656.75
u/ml
0.46
23
130
9
45
2.03
1.24
1.3
1.2
—
—
—
0
0
305
2897
1.34
1.21
47.2
17.2
22.35
24.33
mg/l
0.66
285
2417
7
30
2.36
1.13
1.7
1.4
—
—
—
0
0
47
361
1.35
1.06
1.7
1.4
—
—
—
0
0
27
192
1.44
0.95
1.2
1.3
72.88
387.69
u/ml
1.40
22
177
8
42
1.92
0.89
1.3
1.6
—
—
—
0
0
8
43
1.88
0.88
1.3
1.6
—
—
—
0
0
8
43
1.88
0.88
1.3
1.6
—
—
—
0
0
8
43
1.88
0.88
1.3
1.5
—
—
—
0
0
8
44
1.84
0.86
1.3
1.5
—
—
—
0
0
8
44
1.84
0.86
1.3
1.5
—
—
—
0
0
26
191
1.39
0.79
12.1
2.6
1.25
1.19
%
0.14
26
191
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.3
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
10
59
1.71
0.76
3.0
3.8
23.98
486.75
u/ml
—
10
54
12
75
1.62
0.76
1.5
1.3
—
—
—
0
0
107
1200
0.85
0.74
2.1
2.0
1.33
1.36
mmol/l
0.18
89
1001
287
2753
1.21
0.73
43.2
17.1
72.28
78.97
ml/min/173m2
4.24
274
2556
5
25
2.01
0.73
8.2
4.2
32.40
83.31
u/ml
—
5
25
20
272
0.72
0.70
1.5
2.1
3.41
3.44
ratio
0.03
15
225
276
2865
0.84
0.66
6.3
6.0
2.33
2.64
mmol/l
6.93
249
2645
10
62
1.63
0.65
1.9
1.5
—
—
—
0
0
105
1163
0.86
0.61
5.2
5.6
2.67
2.50
ug/l
0.10
94
1047
12
80
1.52
0.60
1.0
1.2
—
—
—
0
0
12
81
1.50
0.57
1.0
1.2
—
—
—
0
0
21
270
0.76
0.53
2.1
2.5
12.51
13.47
nmol/l
0.21
16
248
7
48
1.47
0.47
2.0
1.7
24.46
17.61
ug/l
—
7
48
7
50
1.41
0.45
2.7
3.1
13.29
31.23
u/ml
—
7
50
12
86
1.41
0.45
1.3
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
1.11
—
0
11
5
35
1.43
0.39
2.4
2.9
2.86
2.84
nmol/l
—
5
35
12
90
1.34
0.36
2.4
1.1
0.92
0.93
g/l
0.03
12
90
6
45
1.34
0.34
1.3
1.8
—
—
—
0
0
7
54
1.30
0.30
1.1
1.9
—
—
—
0
0
274
2683
1.09
0.26
6.5
5.3
2.14
1.95
mu/l
1.24
253
2449
282
2769
1.08
0.23
5.4
5.3
6.13
6.00
mmol/l
0.52
252
2537
277
2719
1.08
0.22
7.6
6.9
37.03
39.73
mmol/mol
3.72
248
2547
5
41
1.22
0.22
1.0
1.1
—
1.32
—
0
5
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
35
386
0.90
0.21
4.0
5.0
33.54
31.95
%
0.28
26
255
17
145
1.18
0.21
1.1
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
8.77
—
0
13
275
2796
0.93
0.20
5.6
5.2
1.42
1.44
mmol/l
0.39
248
2576
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
27
241
1.13
0.19
1.5
1.5
—
—
—
0
0
6
51
1.18
0.19
1.8
1.7
—
—
—
0
0
309
3127
0.92
0.19
76.6
26.0
3.84
4.47
e12/l
37.51
304
3058
17
196
0.86
0.19
1.2
1.9
3.79
3.44
mmol/l
0.42
11
150
18
156
1.16
0.19
1.4
1.9
—
—
—
0
0
7
61
1.15
0.17
1.9
1.7
55.99
50.80
ug/l
—
7
49
15
129
1.17
0.17
1.3
1.8
—
—
—
0
0
16
140
1.15
0.15
1.4
1.3
—
—
—
0
0
7
87
0.80
0.14
1.0
1.1
1.63
1.56
g/l
—
7
87
279
2816
0.96
0.09
5.7
5.3
4.20
4.54
mmol/l
5.98
254
2611
265
2676
0.96
0.09
5.1
4.5
1.25
1.26
mmol/l
0.15
235
2448
35
336
1.05
0.05
11.0
7.5
—
—
—
0
0
236
2377
0.98
0.04
64.0
22.4
331.12
332.16
g/l
0.65
236
2366
25
260
0.96
0.03
1.4
2.1
—
—
—
0
0
18
189
0.95
0.03
1.2
1.2
333.50
137.76
u/ml
—
7
62
49
480
1.02
0.02
1.6
1.5
—
—
—
0
0
28
286
0.98
0.00
1.4
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
78.02
—
0
6
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.7
—
53.18
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_ACQHAEMOLYTICANAEMIANAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQHAEMOLYTICANAEMIANAS | 3.114 [2.46, 3.95] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.071 |
During the follow-up period (1.1.1998 — 31.12.2019), 453 out of 959 females with D3_ACQHAEMOLYTICANAEMIANAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQHAEMOLYTICANAEMIANAS | 3.138 [2.33, 4.22] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 359 out of 817 males with D3_ACQHAEMOLYTICANAEMIANAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_ACQHAEMOLYTICANAEMIANAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.352% | 0.488% |
| 5 | 1.783% | 3.256% |
| 10 | 4.076% | 7.853% |
| 15 | 7.3% | 14.352% |
| 20 | 12.566% | 23.308% |
Relationships between endpoints
↥Index endpoint: D3_ACQHAEMOLYTICANAEMIANAS – Other and unspecified acquired haemolytic anaemias
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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