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Haemolytic-uraemic syndrome

DOID EFO Endpoint Browser PheWeb

D3_NONAIHA_OTHER

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D59.3
  • Hospital discharge: ICD-9 — 2831C
  • Cause of death: ICD-10 — D59.3
  • Cause of death: ICD-9 — 2831C

2 out of 7 registries used, show all original rules.

90

4. Check minimum number of events

None

90

5. Include endpoints

None

90

6. Filter based on genotype QC (FinnGen only)

84

Control definitions (FinnGen only)

Control exclude
D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D59
Name in latin
Syndroma haemolytico-uraemicum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 569 325 242
Only index persons 445 258 187
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 25.46 26.20 24.21
Only index persons 25.69 26.59 24.44

-FinnGen-

Key figures

All Female Male
Number of individuals 84 47 37
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 37.91 31.58 45.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
90
Matched controls
900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.3
ICD-10 Finland
Haemolytic-uraemic syndrome
+∞
73.2
60
*
N08.2*D59.3
ICD-10 Finland
Glomerular disorders in haemolytic-uraemic syndrome
+∞
59.0
50
*
TK800
NOMESCO Finland
Hemodialysis
100.8
38.2
40
7
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
21.1
37.7
33
24
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
84.0
36.2
39
8
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
84.0
36.2
39
8
A11CC03
ATC
alfacalcidol; systemic
72.8
30.0
33
7
Z94.0
ICD-10 Finland
Kidney transplant status
147.4
29.8
30
*
H02AB04
ATC
methylprednisolone; systemic
12.7
28.6
35
43
A12AA04
ATC
calcium carbonate; oral
133.2
27.5
28
*
127
Kela drug reimbursment
Transplant complication
57.9
27.1
31
8
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
126.4
26.3
27
*
L04AA06
ATC
mycophenolic acid; systemic
55.1
26.0
30
8
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
36.3
25.9
33
14
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
+∞
25.2
23
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
75.9
24.7
27
5
N18.0
ICD-10 Finland
End-stage renal disease
161.2
23.9
24
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
8.8
23.6
43
85
B03XA02
ATC
darbepoetin alfa; parenteral
54.0
23.3
27
7
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
286.9
22.7
22
*
C09AA02
ATC
enalapril; systemic
8.9
21.8
36
63
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
270.0
21.6
21
*
C03CA01
ATC
furosemide; systemic
7.4
20.3
45
107
L04AD02
ATC
tacrolimus; systemic
40.1
19.6
24
8
WW400
NOMESCO Finland
Plasmaferesis
+∞
19.5
18
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.8
19.1
35
68
V03AE01
ATC
polystyrene sulfonate; oral
67.5
18.9
21
*
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
+∞
18.3
17
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
118.9
18.3
19
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
53.8
18.2
21
5
205
Kela drug reimbursment
Chronic hypertension
6.6
17.3
40
97
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
59.4
16.8
19
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
68.9
15.4
17
*
137
Kela drug reimbursment
Uraemia requiring dialysis
95.7
15.1
16
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
18.8
15.1
23
16
C02AC05
ATC
moxonidine; oral
28.0
15.0
20
9
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
+∞
15.0
14
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
33.8
15.0
19
7
Z49.0
ICD-10 Finland
Preparatory care for dialysis
177.7
14.9
15
*
C08CA01
ATC
amlodipine; oral
5.6
14.9
52
178
WX408
NOMESCO Finland
General anesthesy, balanced
5.4
14.2
45
141
Z2446
NOMESCO Finland
Social worker
7.1
14.2
26
49
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
88.6
14.0
15
*
Z3231
NOMESCO Finland
Registered nurse
5.2
13.7
48
163
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
59.2
13.3
15
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
21.5
13.2
19
11
L04AA01
ATC
[U] ciclosporin
81.8
13.0
14
*
V03AE02
ATC
sevelamer; oral
81.8
13.0
14
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.1
12.9
60
252
N18.8
ICD-10 Finland
Other chronic renal failure
25.7
12.6
17
8
N17.9
ICD-10 Finland
Acute renal failure, unspecified
18.1
12.5
19
13
B03XA01
ATC
erythropoietin; parenteral
54.6
12.3
14
*
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
11.7
11
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
11.7
11
*
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
+∞
11.7
11
*
L04AD01
ATC
ciclosporin; systemic
29.6
11.6
15
6
R4110
NOMESCO Finland
Physiotherapy
4.5
11.4
43
151
B05DB
ATC
Hypertonic solutions
123.8
10.7
11
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
123.8
10.7
11
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
5.1
10.7
28
73
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
12.9
10.4
18
17
ZX120
NOMESCO Finland
Intravenous
6.0
9.9
20
41
196
Kela drug reimbursment
Paricalcitol and cinacalcet
111.2
9.6
10
*
B05DA
ATC
Isotonic solutions
111.2
9.6
10
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.1
9.6
19
38
ZXA00
NOMESCO Finland
Right side
4.5
9.6
31
95
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.0
9.3
41
157
Z2221
NOMESCO Finland
Medical doctor
3.9
9.3
42
164
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
41.2
9.2
11
*
ZXE00
NOMESCO Finland
One hour or less
3.9
9.1
54
252
ZXE10
NOMESCO Finland
More than one and less than three hours
3.8
9.0
46
194
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.6
8.8
19
27
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
30.9
8.7
11
*
ZXD05
NOMESCO Finland
Urgent procedure
3.7
8.7
44
184
Z3226
NOMESCO Finland
Physiotherapist
4.0
8.6
32
108
ZXE20
NOMESCO Finland
More than three and less than five hours
4.7
8.6
24
65
Z49.2
ICD-10 Finland
Other dialysis
98.9
8.6
9
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
8.5
8
*
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
+∞
8.5
8
*
C07AG02
ATC
carvedilol; oral
11.7
8.4
15
15
H05BX01
ATC
cinacalcet; oral
49.4
7.9
9
*
M04AA01
ATC
allopurinol; systemic
5.2
7.8
18
41
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
9.2
7.5
15
19
RD210, ,
NOMESCO Finland
17.6
7.4
11
7
PBU84
NOMESCO Finland
Plastic repair of arteriovenous fistula from artery of upper extremity
+∞
7.4
7
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
32.9
7.3
9
*
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
32.9
7.3
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.7
7.1
29
103
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
43.5
6.9
8
*
TK810
NOMESCO Finland
Hemofiltration
43.5
6.9
8
*
C02CA01
ATC
prazosin; oral
43.5
6.9
8
*
C07AB02
ATC
metoprolol; systemic
3.8
6.6
24
78
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
74.9
6.5
7
*
C08CA02
ATC
felodipine; oral
7.3
6.5
15
24
3025
Kela drug reimbursment
Calcium carbonate
28.9
6.3
8
*
L04AA05
ATC
[U] tacrolimus
28.9
6.3
8
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
7.7
6.3
14
21
A12AA12
ATC
[U] calcium acetate
+∞
6.3
6
*
V03AE03
ATC
lanthanum carbonate; oral
+∞
6.3
6
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
+∞
6.3
6
*
WX002
NOMESCO Finland
Sedation and analgesia
3.7
6.2
23
76

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Immunoglobulin A (IgA) nephropathy
N08.2*D89.80 (2000503126)
darbepoetin alfa; parenteral
B03XA02 (21601134)
Glomerular disorders in haemolytic-uraemic syndrome
N08.2*D59.3 (2000503122)
Hemodialysis
TK800 (2001305768)
FISTULA - Fistula
FISTULA-1 (2002330212)
Haemolytic-uraemic syndrome
D59.3 (45542712)
mycophenolic acid; oral, parenteral
L04AA06 (21603896)
Extracorporeal dialysis
Z49.1 (45537649)
Severe anaemia associated with chronic renal failure
138 (2001600134)
ANTIHYPERTENSIVE_DRUG - yes
ANTIHYPERTENSIVE_DRUG-1 (2002330215)
Complement C3 [Mass/volume] in Serum or Plasma
4485-9 (3000620)
Complement C4 [Mass/volume] in Serum or Plasma
4498-2 (3017766)
Thorax X-ray examination
GD1AA (2001303617)
Plasmaferesis
WW400 (2001310600)
alfacalcidol; oral, parenteral
A11CC03 (21600818)
Phosphate [Moles/volume] in Serum or Plasma
14879-1 (3003458)
C reactive protein [Mass/volume] in Serum or Plasma
1988-5 (3020460)
Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
14804-9 (3022250)
Internal Medicine
11 (38004456)
Nephrology
39 (38004479)
Outpatient Hospital
22 (8756)
Albumin [Mass/volume] in Serum or Plasma
1751-7 (3024561)
Outpatient Visit
OP (9202)
Calcium.ionized [Moles/volume] in Serum or Plasma
1995-0 (3021347)
Ferritin [Mass/volume] in Serum or Plasma
2276-4 (3001122)
Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
19072-8 (3016431)
Urea [Moles/volume] in Serum or Plasma
22664-7 (3020779)
furosemide; oral, parenteral
C03CA01 (21601518)
Iron/Transferrin [Ratio] in Serum or Plasma
60517-0 (40763571)
Casts [#/volume] in Urine by Automated count
51483-6 (3030467)
Bacteria [Presence] in Urine
87829-8 (36304419)
Iron [Moles/volume] in Serum or Plasma
14798-3 (3022948)
Transferrin [Mass/volume] in Serum or Plasma
3034-6 (3004789)
calcium (different salts in combination); oral
A12AA20 (21600872)
pH of Serum or Plasma
2753-2 (3018418)
amlodipine; oral
C08CA01 (21601747)
Parathyrin.intact [Mass/volume] in Serum or Plasma
2731-8 (3000067)
methylprednisolone; oral, parenteral
H02AB04 (21602732)
Inpatient Hospital
21 (8717)
Potassium [Moles/volume] in Serum or Plasma
2823-3 (3023103)
Sodium [Moles/volume] in Serum or Plasma
2951-2 (3019550)
Creatinine [Moles/volume] in Serum or Plasma
14682-9 (3020564)
Erythrocyte [DistWidth] in Red Blood Cells
30385-9 (3002385)
Hematocrit [Volume Fraction] of Blood by calculation
20570-8 (3009542)
Platelets [#/volume] in Blood
26515-7 (3007461)
MCV [Entitic mean volume] in Red Blood Cells
30428-7 (3024731)
Erythrocytes [#/volume] in Blood
26453-1 (3026361)
MCH [Entitic mass]
28539-5 (3035941)
Leukocytes [#/volume] in Blood
26464-8 (3010813)
Hemoglobin [Mass/volume] in Blood
718-7 (3000963)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
52
87
12.79
34.41
12.4
3.2
24.31
26.60
%
0.44
52
80
54
108
11.00
30.32
12.0
2.9
12.40
15.96
umol/l
2.15
54
97
38
52
11.92
28.76
7.4
3.0
85.19
72.99
e9/l
0.53
24
36
60
185
7.73
20.83
30.4
4.0
7.39
7.40
ph
0.19
47
132
44
103
7.40
20.14
19.6
5.2
7.37
7.38
ph
0.23
32
63
38
78
7.70
19.71
21.2
4.7
23.29
23.46
mmol/l
0.15
38
78
44
113
6.66
18.04
8.9
3.1
2.81
1.87
e6/l
0.24
27
59
39
90
6.88
17.83
30.0
10.1
—
—
—
0
0
16
0
+∞
17.22
11.4
0.0
6.01
—
mmol/l
—
16
0
18
5
44.30
15.10
7.4
1.6
56.28
121.60
mg/l
—
18
5
57
211
5.64
14.89
13.2
3.0
0.22
0.31
e6/l
0.29
46
157
61
250
5.47
13.78
14.2
3.1
38.03
48.88
e6/l
0.15
52
194
20
13
19.35
13.38
2.0
1.9
—
—
—
0
0
24
45
6.91
13.13
2.4
1.6
—
—
—
0
0
17
7
29.43
13.03
1.8
1.6
—
—
—
0
0
23
24
12.46
12.69
2.4
1.6
183.61
163.17
u/ml
0.14
18
12
51
193
4.79
12.43
12.6
3.3
242.62
106.10
mg/l
0.86
45
132
22
24
11.74
11.86
2.9
1.7
—
—
—
0
0
31
82
5.24
11.69
21.7
9.7
23.89
24.40
mmol/l
0.38
31
82
22
25
11.26
11.62
3.0
1.7
121.83
179.88
au/ml
—
6
8
34
99
4.91
11.41
2.2
1.9
—
—
—
0
0
19
17
13.82
11.20
12.5
5.2
80.95
64.84
%
2.44
19
17
17
12
17.11
11.01
1.2
1.3
—
—
—
0
0
49
195
4.32
10.83
14.2
4.0
34.62
14.76
mg/mmol
1.18
43
128
45
170
4.29
10.65
11.9
3.8
—
—
—
0
0
59
271
4.42
10.63
15.5
5.4
—
—
—
0
0
62
297
4.50
10.50
18.8
3.8
9.75
30.15
e6/l
1.64
52
199
37
124
4.37
10.24
4.7
1.7
—
—
—
0
0
27
72
4.93
9.95
3.0
1.7
—
—
—
0
0
17
16
12.79
9.79
13.9
5.4
80.24
64.80
%
2.09
17
16
18
21
10.41
9.34
2.2
1.5
—
—
—
0
0
29
90
4.28
8.73
22.3
8.0
103.34
104.90
mmol/l
0.71
29
90
11
5
24.74
8.23
1.2
1.0
—
—
—
0
0
20
51
4.76
7.64
1.8
1.5
—
—
—
0
0
50
244
3.36
7.44
4.8
2.1
—
—
—
0
0
7
0
+∞
7.38
1.0
0.0
—
—
—
0
0
13
13
11.46
7.31
3.8
2.3
—
—
—
0
0
14
17
9.52
7.14
2.6
1.2
5.56
3.40
u/ml
—
9
10
40
174
3.34
7.14
4.5
2.1
5.79
0.88
mg/l
1.09
35
139
32
123
3.49
6.93
4.3
3.1
352.08
771.73
ng/l
0.50
26
83
47
230
3.18
6.82
4.4
2.4
—
—
—
0
0
22
66
4.09
6.80
30.8
10.9
0.53
0.78
mmol/l
0.10
22
56
50
255
3.16
6.73
12.4
5.2
—
—
—
0
0
16
27
6.96
6.68
1.4
1.3
—
—
—
0
0
22
67
4.02
6.66
30.8
10.7
7.44
7.42
ph
0.78
11
37
10
8
13.85
6.25
1.4
1.0
—
—
—
0
0
11
11
11.19
6.23
1.2
1.1
—
—
—
0
0
66
414
3.23
5.88
16.7
5.9
0.04
0.04
e9/l
0.12
59
362
66
414
3.23
5.88
16.7
5.9
0.64
0.57
e9/l
1.32
59
363
70
458
3.38
5.72
20.9
9.3
4.41
3.81
e9/l
1.04
64
408
40
194
2.91
5.68
4.7
1.9
—
—
—
0
0
51
283
2.85
5.60
20.7
10.8
1.17
1.17
inr
0.01
41
229
15
30
5.78
5.56
24.4
18.2
24.00
24.02
mmol/l
0.01
15
30
66
422
3.11
5.53
16.7
6.0
1.78
2.09
e9/l
2.00
59
380
11
14
8.77
5.53
9.7
3.7
—
—
—
0
0
25
97
3.18
5.19
2.0
1.5
448.00
506.00
titre
—
5
20
66
431
2.99
5.15
17.6
6.5
0.20
0.21
e9/l
0.05
61
385
12
21
6.42
4.95
4.3
2.5
10.57
2.50
index
—
7
12
11
17
7.20
4.94
1.4
1.4
—
—
—
0
0
59
369
2.74
4.91
13.5
6.2
16.22
17.04
umol/l
0.06
59
353
45
249
2.61
4.77
9.2
3.0
—
0.00
—
0
5
56
349
2.60
4.58
9.3
3.3
5.98
6.23
ph
0.90
24
191
63
417
2.70
4.52
11.4
3.6
0.00
0.00
estimate
-0.00
12
79
55
344
2.54
4.40
4.9
2.7
—
—
estimate
—
0
0
63
421
2.65
4.37
11.4
3.6
0.00
0.00
estimate
-0.00
12
82
9
13
7.55
4.28
7.0
6.1
10.72
10.45
%
—
9
13
14
42
3.76
4.24
26.2
14.7
92.06
95.09
%
0.87
14
42
8
10
8.64
4.15
4.8
1.8
1.28
1.49
mmol/l
—
8
10
63
427
2.58
4.14
11.5
3.7
0.00
0.00
estimate
-0.00
12
77
12
28
4.78
3.99
3.1
3.1
—
—
—
0
0
13
36
4.04
3.68
1.2
1.2
—
—
—
0
0
7
9
8.31
3.63
2.3
1.2
—
—
—
0
0
7
9
8.31
3.63
2.4
1.4
—
—
—
0
0
18
71
2.92
3.56
29.1
6.6
—
—
—
0
0
9
18
5.43
3.47
13.0
3.5
14.37
11.83
pmol/l
—
9
18
7
10
7.48
3.43
1.3
1.4
—
—
—
0
0
54
363
2.22
3.32
35.3
9.6
0.01
0.00
e9/l
0.80
43
286
6
7
9.07
3.31
5.2
3.0
19.50
17.86
index
—
6
7
6
7
9.07
3.31
5.0
2.7
0.50
0.57
index
—
6
7
45
285
2.16
3.17
2.4
2.0
102.89
94.74
pmol/l
0.63
26
155
8
16
5.37
3.13
7.5
2.5
117.62
132.50
g/l
—
8
10
43
269
2.15
3.11
1.6
1.7
—
—
—
0
0
9
21
4.64
3.09
6.9
2.8
60.56
51.84
%
—
9
21
7
12
6.22
3.08
1.3
1.4
—
—
—
0
0
7
12
6.22
3.08
4.1
1.1
30.57
32.08
pg
—
7
12
7
12
6.22
3.08
7.0
3.8
4.40
4.38
e9/l
—
7
12
18
81
2.53
2.76
1.8
1.5
—
—
—
0
0
6
10
6.33
2.74
4.3
1.1
1.50
1.30
%
—
6
5
5
7
7.47
2.58
1.0
1.3
—
—
—
0
0
34
209
2.01
2.47
4.1
2.7
—
—
—
0
0
7
19
3.90
2.20
4.3
2.4
—
—
—
0
0
6
14
4.51
2.19
12.8
2.9
4.68
4.88
kpa
—
6
14
6
14
4.51
2.19
12.8
2.9
9.82
8.92
kpa
—
6
14
7
20
3.70
2.10
1.1
1.1
—
—
—
0
0
7
20
3.70
2.10
12.7
4.1
7.40
7.42
ph
—
7
20
20
109
2.07
1.97
2.4
1.4
—
—
—
0
0
26
159
1.89
1.86
2.2
2.0
—
—
—
0
0
16
84
2.10
1.73
1.6
1.2
—
—
—
0
0
8
31
2.73
1.70
37.8
4.4
—
—
—
0
0
6
20
3.14
1.61
1.8
1.3
—
—
—
0
0
5
17
3.05
1.37
2.0
1.4
—
—
—
0
0
5
17
3.05
1.37
2.0
1.4
—
—
—
0
0
5
17
3.05
1.37
2.0
1.4
—
—
—
0
0
5
17
3.05
1.37
2.0
1.4
—
—
—
0
0
35
259
1.57
1.22
3.4
2.0
—
—
—
0
0
21
298
0.61
1.12
4.0
2.9
—
—
—
0
0
13
76
1.83
1.05
1.2
1.4
—
—
—
0
0
82
756
1.95
1.04
56.4
12.7
17.89
21.62
mg/l
1.03
74
608
6
28
2.22
0.93
1.7
1.1
0.91
0.83
g/l
—
6
28
10
59
1.78
0.79
18.6
3.4
—
—
—
0
0
0
27
0.00
0.79
0.0
2.7
—
3.52
—
0
14
11
166
0.62
0.73
1.3
1.8
—
—
—
0
0
5
26
1.98
0.72
1.0
1.1
1.46
1.62
g/l
—
5
26
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
82
777
1.62
0.60
49.8
11.4
—
—
—
0
0
12
86
1.46
0.47
1.8
1.2
—
—
—
0
0
5
35
1.45
0.40
1.0
1.2
—
—
—
0
0
5
36
1.41
0.39
9.8
1.6
—
—
—
0
0
27
230
1.25
0.37
11.5
2.9
0.00
0.00
estimate
—
9
67
25
212
1.25
0.35
1.7
1.4
2.59
2.26
g/l
0.27
16
124
5
40
1.26
0.23
1.2
2.1
—
—
—
0
0
5
42
1.20
0.22
1.6
1.6
—
—
—
0
0
5
42
1.20
0.22
1.8
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
6.47
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
9.92
—
0
12
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
3.6
—
—
—
0
0
9
77
1.19
0.16
1.0
1.4
—
—
—
0
0
25
228
1.13
0.15
6.1
3.7
91.42
30.09
ng/l
0.51
19
140
24
220
1.12
0.13
12.7
3.5
0.00
0.01
estimate
—
10
73
84
829
1.20
0.08
85.3
20.4
118.24
135.50
g/l
11.85
84
822
84
829
1.20
0.08
84.6
19.9
30.08
30.00
pg
0.15
84
821
84
829
1.20
0.08
90.1
20.8
35.77
40.49
%
10.48
84
822
84
829
1.20
0.08
84.7
20.0
90.92
89.70
fl
1.35
84
822
84
829
1.20
0.08
84.7
20.1
7.29
6.89
e9/l
0.88
84
815
84
829
1.20
0.08
84.6
20.0
4.04
4.54
e12/l
9.48
84
816
84
828
1.22
0.08
84.9
20.1
245.58
256.58
e9/l
0.59
84
815
19
180
1.07
0.04
3.4
5.1
1.76
2.07
ug/l
0.26
19
164
10
92
1.10
0.03
1.3
1.2
—
—
—
0
0
32
312
1.04
0.02
11.8
3.4
0.00
0.01
estimate
0.49
11
67
0
9
0.00
0.00
0.0
8.3
—
0.62
—
0
9
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
1.52
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
135.60
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
7.48
—
0
6
0
7
0.00
-0.00
0.0
4.6
—
1.21
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
65.88
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
19
190
1.00
-0.00
13.5
4.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
11.57
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
0.00
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint D3_NONAIHA_OTHER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_NONAIHA_OTHER.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: D3_NONAIHA_OTHER – Haemolytic-uraemic syndrome

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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