No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
97 |
4. Check minimum number of eventsNone |
97 |
5. Include endpointsNone |
97 |
6. Filter based on genotype QC (FinnGen only) |
84 |
Control definitions (FinnGen only)
- Control exclude
- D3_HAEMOLYTICANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D59
- Name in latin
- Syndroma haemolytico-uraemicum
Similar endpoints
↥List of similar endpoints to
Haemolytic-uraemic syndrome
based on the number of shared cases.
Similar with more cases:
- Acquired haemolytic anaemia
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 569 | 325 | 242 |
| Only index persons | 445 | 258 | 187 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 25.46 | 26.20 | 24.21 |
| Only index persons | 25.69 | 26.59 | 24.44 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 84 | 47 | 37 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 37.91 | 31.58 | 45.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 90
- Matched controls
- 900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.3
ICD-10 Finland
Haemolytic-uraemic syndrome
+∞
73.2
60
*
N08.2*D59.3
ICD-10 Finland
Glomerular disorders in haemolytic-uraemic syndrome
+∞
59.0
50
*
TK800
NOMESCO Finland
Hemodialysis
100.8
38.2
40
7
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
21.1
37.7
33
24
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
84.0
36.2
39
8
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
84.0
36.2
39
8
A11CC03
ATC
alfacalcidol; systemic
72.8
30.0
33
7
Z94.0
ICD-10 Finland
Kidney transplant status
147.4
29.8
30
*
H02AB04
ATC
methylprednisolone; systemic
12.7
28.6
35
43
A12AA04
ATC
calcium carbonate; oral
133.2
27.5
28
*
127
Kela drug reimbursment
Transplant complication
57.9
27.1
31
8
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
126.4
26.3
27
*
L04AA06
ATC
mycophenolic acid; systemic
55.1
26.0
30
8
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
36.3
25.9
33
14
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
+∞
25.2
23
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
75.9
24.7
27
5
N18.0
ICD-10 Finland
End-stage renal disease
161.2
23.9
24
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
8.8
23.6
43
85
B03XA02
ATC
darbepoetin alfa; parenteral
54.0
23.3
27
7
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
286.9
22.7
22
*
C09AA02
ATC
enalapril; systemic
8.9
21.8
36
63
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
270.0
21.6
21
*
C03CA01
ATC
furosemide; systemic
7.4
20.3
45
107
L04AD02
ATC
tacrolimus; systemic
40.1
19.6
24
8
WW400
NOMESCO Finland
Plasmaferesis
+∞
19.5
18
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.8
19.1
35
68
V03AE01
ATC
polystyrene sulfonate; oral
67.5
18.9
21
*
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
+∞
18.3
17
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
118.9
18.3
19
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
53.8
18.2
21
5
205
Kela drug reimbursment
Chronic hypertension
6.6
17.3
40
97
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
59.4
16.8
19
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
68.9
15.4
17
*
137
Kela drug reimbursment
Uraemia requiring dialysis
95.7
15.1
16
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
18.8
15.1
23
16
C02AC05
ATC
moxonidine; oral
28.0
15.0
20
9
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
+∞
15.0
14
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
33.8
15.0
19
7
Z49.0
ICD-10 Finland
Preparatory care for dialysis
177.7
14.9
15
*
C08CA01
ATC
amlodipine; oral
5.6
14.9
52
178
WX408
NOMESCO Finland
General anesthesy, balanced
5.4
14.2
45
141
Z2446
NOMESCO Finland
Social worker
7.1
14.2
26
49
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
88.6
14.0
15
*
Z3231
NOMESCO Finland
Registered nurse
5.2
13.7
48
163
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
59.2
13.3
15
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
21.5
13.2
19
11
V03AE02
ATC
sevelamer; oral
81.8
13.0
14
*
L04AA01
ATC
[U] ciclosporin
81.8
13.0
14
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.1
12.9
60
252
N18.8
ICD-10 Finland
Other chronic renal failure
25.7
12.6
17
8
N17.9
ICD-10 Finland
Acute renal failure, unspecified
18.1
12.5
19
13
B03XA01
ATC
erythropoietin; parenteral
54.6
12.3
14
*
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
+∞
11.7
11
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
11.7
11
*
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
11.7
11
*
L04AD01
ATC
ciclosporin; systemic
29.6
11.6
15
6
R4110
NOMESCO Finland
Physiotherapy
4.5
11.4
43
151
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
123.8
10.7
11
*
B05DB
ATC
Hypertonic solutions
123.8
10.7
11
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
5.1
10.7
28
73
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
12.9
10.4
18
17
ZX120
NOMESCO Finland
Intravenous
6.0
9.9
20
41
B05DA
ATC
Isotonic solutions
111.2
9.6
10
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
111.2
9.6
10
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.1
9.6
19
38
ZXA00
NOMESCO Finland
Right side
4.5
9.6
31
95
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.0
9.3
41
157
Z2221
NOMESCO Finland
Medical doctor
3.9
9.3
42
164
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
41.2
9.2
11
*
ZXE00
NOMESCO Finland
One hour or less
3.9
9.1
54
252
ZXE10
NOMESCO Finland
More than one and less than three hours
3.8
9.0
46
194
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.6
8.8
19
27
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
30.9
8.7
11
*
ZXD05
NOMESCO Finland
Urgent procedure
3.7
8.7
44
184
Z3226
NOMESCO Finland
Physiotherapist
4.0
8.6
32
108
ZXE20
NOMESCO Finland
More than three and less than five hours
4.7
8.6
24
65
Z49.2
ICD-10 Finland
Other dialysis
98.9
8.6
9
*
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
+∞
8.5
8
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
8.5
8
*
C07AG02
ATC
carvedilol; oral
11.7
8.4
15
15
H05BX01
ATC
cinacalcet; oral
49.4
7.9
9
*
M04AA01
ATC
allopurinol; systemic
5.2
7.8
18
41
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
9.2
7.5
15
19
RD210, ,
NOMESCO Finland
17.6
7.4
11
7
PBU84
NOMESCO Finland
Plastic repair of arteriovenous fistula from artery of upper extremity
+∞
7.4
7
*
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
32.9
7.3
9
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
32.9
7.3
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.7
7.1
29
103
C02CA01
ATC
prazosin; oral
43.5
6.9
8
*
TK810
NOMESCO Finland
Hemofiltration
43.5
6.9
8
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
43.5
6.9
8
*
C07AB02
ATC
metoprolol; systemic
3.8
6.6
24
78
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
74.9
6.5
7
*
C08CA02
ATC
felodipine; oral
7.3
6.5
15
24
L04AA05
ATC
[U] tacrolimus
28.9
6.3
8
*
3025
Kela drug reimbursment
Calcium carbonate
28.9
6.3
8
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
7.7
6.3
14
21
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
+∞
6.3
6
*
V03AE03
ATC
lanthanum carbonate; oral
+∞
6.3
6
*
A12AA12
ATC
[U] calcium acetate
+∞
6.3
6
*
WX002
NOMESCO Finland
Sedation and analgesia
3.7
6.2
23
76
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
52
87
12.79
34.41
12.4
3.2
24.31
26.60
%
0.44
52
80
54
108
11.00
30.32
12.0
2.9
12.40
15.96
umol/l
2.15
54
97
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
29
12
34.84
22.66
5.1
8.1
0.28
0.33
iu/ml
—
15
6
26
33
10.67
20.28
4.0
3.3
198.46
177.27
%
0.70
26
33
38
78
7.70
19.71
21.2
4.7
23.29
23.46
mmol/l
0.15
38
78
44
113
6.66
18.04
8.9
3.1
2.81
1.87
e6/l
0.24
27
59
16
0
+∞
17.22
11.4
0.0
6.01
—
mmol/l
—
16
0
44
125
5.93
15.86
8.7
3.0
0.54
0.74
e6/l
0.39
28
70
25
41
8.06
15.62
10.3
2.2
28.67
77.13
ml/min/173m2
—
9
16
57
211
5.64
14.89
13.2
3.0
0.22
0.31
e6/l
0.29
46
157
23
41
7.19
13.19
1.9
1.6
—
—
—
0
0
21
34
7.75
13.13
2.4
1.6
—
—
—
0
0
19
12
19.66
12.83
1.9
1.8
—
—
—
0
0
23
24
12.46
12.69
2.4
1.6
183.61
163.17
u/ml
0.14
18
12
23
26
11.48
12.20
2.3
1.5
—
—
—
0
0
11
0
+∞
11.71
1.4
0.0
—
—
—
0
0
11
0
+∞
11.71
1.4
0.0
—
—
—
0
0
31
82
5.24
11.69
21.7
9.7
23.89
24.40
mmol/l
0.38
31
82
22
25
11.26
11.62
3.0
1.7
121.83
179.88
au/ml
—
6
8
25
58
5.58
10.87
6.4
3.2
—
—
—
0
0
49
195
4.32
10.83
14.2
4.0
34.62
14.76
mg/mmol
1.18
43
128
45
173
4.20
10.34
3.4
2.0
—
—
—
0
0
17
16
12.79
9.79
13.9
5.4
80.24
64.80
%
2.09
17
16
13
6
24.94
9.66
1.2
1.0
—
—
—
0
0
29
90
4.28
8.73
22.3
8.0
103.34
104.90
mmol/l
0.71
29
90
20
32
7.72
8.64
2.8
1.5
—
—
—
0
0
15
15
11.74
8.41
2.5
1.2
3.13
1.50
u/ml
—
8
6
13
11
13.56
7.87
1.2
1.1
—
—
—
0
0
22
63
4.30
7.26
3.0
2.8
66.94
28.00
u/l
0.81
17
50
14
17
9.52
7.14
2.6
1.2
5.56
3.40
u/ml
—
9
10
40
174
3.34
7.14
4.5
2.1
5.79
0.88
mg/l
1.09
35
139
27
92
3.76
7.01
3.5
1.8
—
—
—
0
0
32
123
3.49
6.93
4.3
3.1
352.08
771.73
ng/l
0.50
26
83
22
66
4.09
6.80
30.8
10.9
0.53
0.78
mmol/l
0.10
22
56
27
95
3.63
6.66
3.4
1.7
—
—
—
0
0
24
79
3.78
6.51
23.9
6.5
1.24
1.28
mmol/l
0.02
18
59
30
123
3.16
5.73
4.0
1.9
—
—
—
0
0
70
458
3.38
5.72
20.9
9.3
4.41
3.81
e9/l
1.04
64
408
15
30
5.78
5.56
24.4
18.2
24.00
24.02
mmol/l
0.01
15
30
12
18
7.51
5.46
1.6
1.1
—
—
—
0
0
12
21
6.42
4.95
4.3
2.5
10.57
2.50
index
—
7
12
59
369
2.74
4.91
13.5
6.2
16.22
17.04
umol/l
0.06
59
353
13
26
5.66
4.85
2.5
1.3
—
—
—
0
0
12
23
5.85
4.65
1.4
1.3
—
—
—
0
0
63
417
2.70
4.52
11.4
3.6
0.00
0.00
estimate
-0.00
12
79
55
344
2.54
4.40
4.9
2.7
—
—
estimate
—
0
0
8
9
9.61
4.37
3.7
1.1
0.00
0.00
g/l
—
8
9
63
421
2.65
4.37
11.4
3.6
0.00
0.00
estimate
-0.00
12
82
14
42
3.76
4.24
26.2
14.7
92.06
95.09
%
0.87
14
42
8
10
8.64
4.15
1.1
1.5
—
—
—
0
0
63
427
2.58
4.14
11.5
3.7
0.00
0.00
estimate
-0.00
12
77
8
11
7.85
3.95
2.5
1.3
—
—
—
0
0
8
11
7.85
3.95
2.8
1.4
—
—
—
0
0
10
20
5.48
3.81
1.5
1.2
—
—
—
0
0
9
18
5.43
3.47
13.0
3.5
14.37
11.83
pmol/l
—
9
18
7
10
7.48
3.43
1.3
1.5
—
—
—
0
0
7
10
7.48
3.43
1.3
1.5
—
—
—
0
0
7
10
7.48
3.43
1.3
1.4
—
—
—
0
0
7
10
7.48
3.43
1.3
1.5
—
—
—
0
0
9
19
5.14
3.33
2.1
2.2
—
—
—
0
0
6
7
9.07
3.31
4.5
6.9
104.83
103.14
%
—
6
7
6
7
9.07
3.31
5.2
3.0
19.50
17.86
index
—
6
7
10
25
4.36
3.19
2.8
1.5
—
—
—
0
0
45
285
2.16
3.17
2.4
2.0
102.89
94.74
pmol/l
0.63
26
155
8
16
5.37
3.13
7.5
2.5
117.62
132.50
g/l
—
8
10
10
26
4.19
3.09
2.8
1.6
—
—
—
0
0
10
26
4.19
3.09
1.4
1.4
—
15.25
—
0
6
5
5
10.48
3.01
1.6
1.4
—
—
—
0
0
5
5
10.48
3.01
3.0
1.4
—
—
—
0
0
7
13
5.73
2.93
1.3
1.4
—
—
—
0
0
7
13
5.73
2.93
1.3
1.4
—
—
—
0
0
7
14
5.32
2.78
2.7
1.6
—
—
—
0
0
6
10
6.33
2.74
1.0
1.2
99.67
91.70
%
—
6
10
7
15
4.96
2.65
1.3
1.5
—
—
—
0
0
5
9
5.81
2.24
1.8
1.9
—
—
—
0
0
7
19
3.90
2.20
1.1
1.1
—
—
—
0
0
6
14
4.51
2.19
1.7
1.2
—
—
—
0
0
7
20
3.70
2.10
1.1
1.1
—
—
—
0
0
6
15
4.20
2.07
2.7
1.9
—
—
—
0
0
75
645
1.98
1.61
53.5
11.7
56.44
89.40
ml/min/173m2
8.94
65
581
5
15
3.46
1.54
1.0
1.1
—
—
—
0
0
5
15
3.46
1.54
1.4
1.1
—
—
—
0
0
5
15
3.46
1.54
1.4
1.1
—
—
—
0
0
14
235
0.52
1.42
1.7
1.9
—
—
—
0
0
6
23
2.72
1.39
1.8
1.5
—
—
—
0
0
5
19
2.72
1.23
1.8
1.5
—
—
—
0
0
8
39
2.15
1.18
1.9
1.5
—
—
—
0
0
82
756
1.95
1.04
56.4
12.7
17.89
21.62
mg/l
1.03
74
608
0
28
0.00
0.99
0.0
1.3
—
—
—
0
0
83
770
2.00
0.97
31.6
10.3
22.19
25.88
u/l
2.05
83
756
60
517
1.48
0.94
6.6
3.5
51.15
35.18
u/l
0.41
60
498
6
28
2.22
0.93
1.7
1.1
0.91
0.83
g/l
—
6
28
8
48
1.73
0.81
1.3
1.2
—
—
—
0
0
5
26
1.98
0.72
1.0
1.1
1.46
1.62
g/l
—
5
26
7
42
1.72
0.70
1.1
1.5
—
—
—
0
0
21
160
1.41
0.61
1.7
1.6
—
—
—
0
0
0
21
0.00
0.61
0.0
1.0
—
—
—
0
0
0
22
0.00
0.60
0.0
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
27
230
1.25
0.37
11.5
2.9
0.00
0.00
estimate
—
9
67
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
10
119
0.82
0.16
2.0
2.1
—
—
—
0
0
25
228
1.13
0.15
6.1
3.7
91.42
30.09
ng/l
0.51
19
140
8
98
0.80
0.14
2.0
1.9
—
—
—
0
0
24
220
1.12
0.13
12.7
3.5
0.00
0.01
estimate
—
10
73
62
599
1.11
0.13
4.4
4.0
—
—
—
0
0
16
175
0.90
0.09
1.7
2.6
—
—
—
0
0
6
55
1.10
0.09
1.3
1.3
—
—
—
0
0
84
829
1.20
0.08
84.7
20.0
90.92
89.70
fl
1.35
84
822
84
829
1.20
0.08
90.1
20.8
35.77
40.49
%
10.48
84
822
84
829
1.20
0.08
85.3
20.4
118.24
135.50
g/l
11.85
84
822
15
162
0.91
0.06
1.6
2.4
—
—
—
0
0
19
180
1.07
0.04
3.4
5.1
1.76
2.07
ug/l
0.26
19
164
32
312
1.04
0.02
11.8
3.4
0.00
0.01
estimate
0.49
11
67
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
166.28
—
0
6
0
5
0.00
-0.00
0.0
2.2
—
10.44
—
0
5
0
5
0.00
-0.00
0.0
2.2
—
4.70
—
0
5
5
49
1.02
-0.00
1.6
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
0.03
—
0
5
0
8
0.00
-0.00
0.0
1.5
—
13.50
—
0
8
Mortality – FinRegistry
↥Association
Association between endpoint D3_NONAIHA_OTHER and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_NONAIHA_OTHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_NONAIHA_OTHER – Haemolytic-uraemic syndrome
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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