Other hereditary haemolytic anaemias

D3_HEREDHAEMOLYTICANAEMIAOTHER

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D58
  • Cause of death: ICD-10 D58

2 out of 7 registries used, show all original rules.

201

4. Check minimum number of events

None

201

5. Include endpoints

256

6. Filter based on genotype QC (FinnGen only)

216

Control definitions (FinnGen only)

Control exclude
D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D55-D59
Name in latin
Aliae anaemiae haemolyticae hereditariae

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2471 1228 1174
Only index persons 1959 1005 954
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.03
Only index persons 0.04 0.04 0.04
Median age at first event (years)
Whole population 24.85 27.81 21.09
Only index persons 25.64 27.68 23.49

-FinnGen-

Key figures

All Female Male
Number of individuals 216 122 94
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 40.28 35.91 45.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
235
Matched controls
2350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D58.2
ICD-10 Finland
Other haemoglobinopathies
+∞
84.6
76
*
D58.0
ICD-10 Finland
Hereditary spherocytosis
+∞
81.0
73
*
28200
ICD-8 Finland
Hereditary haemolytic anaemias, Familial acholuric jaundice
+∞
35.3
33
*
D58.9
ICD-10 Finland
Hereditary haemolytic anaemia, unspecified
+∞
22.2
21
*
2820A
ICD-9 Finland
Hereditary haemolytic anaemias, Hereditary spherocytosis
+∞
19.0
18
*
D64.9
ICD-10 Finland
Anaemia, unspecified
4.9
17.9
45
109
D58.8
ICD-10 Finland
Other specified hereditary haemolytic anaemias
+∞
14.7
14
*
D58.1
ICD-10 Finland
Hereditary elliptocytosis
+∞
14.7
14
*
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
+∞
12.6
12
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.9
11.4
37
108
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
10.5
10
*
D75.1
ICD-10 Finland
Secondary polycythaemia
104.0
9.5
10
*
28299
ICD-8 Finland
Hereditary haemolytic anaemias, Other
+∞
9.4
9
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
9.1
48
189
WW500
NOMESCO Finland
Blood transfusion
5.2
8.5
18
37
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.9
7.5
38
146
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
82.6
7.5
8
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
7.1
76
415
JMA10
NOMESCO Finland
Transabdominal total splenectomy
17.3
6.8
10
6
XW000
NOMESCO Finland
Bone marrow biopsy
6.5
6.6
16
26
D50.8
ICD-10 Finland
Other iron deficiency anaemias
18.6
6.3
9
5
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
18.6
6.3
9
5
6753
FHL
Transabdominal splenectomy
+∞
6.3
6
*
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
114
209
9.65
67.15
8.7
2.9
3.62
1.72
%
10.71
109
188
71
80
12.28
60.88
4.3
1.5
0.75
1.53
g/l
6.47
51
70
90
161
8.44
52.84
7.2
2.8
139.30
72.11
e9/l
8.65
73
105
129
516
4.33
27.64
3.6
2.3
4.65
2.81
mg/l
3.25
118
446
28
20
15.72
17.31
1.3
1.3
—
—
—
0
0
176
1083
3.49
16.19
10.3
6.2
0.64
0.57
e9/l
1.55
161
926
178
1106
3.51
16.04
10.3
6.3
1.95
2.05
e9/l
0.39
167
969
176
1087
3.47
16.00
10.3
6.2
0.05
0.04
e9/l
1.11
161
926
178
1119
3.44
15.45
10.6
6.7
0.18
0.20
e9/l
1.15
167
973
183
1189
3.44
14.63
16.5
10.1
4.53
4.06
e9/l
1.62
166
1040
164
1020
3.01
13.77
5.6
3.1
171.86
101.55
ug/l
3.71
157
968
170
1085
3.05
13.48
14.0
6.4
19.18
11.28
umol/l
8.01
165
1029
72
291
3.13
13.47
1.9
1.6
1205.69
1231.73
nmol/l
0.08
61
219
137
856
2.44
10.10
7.7
5.1
37.28
36.30
g/l
1.16
131
814
118
691
2.42
10.05
9.7
6.2
—
—
—
0
0
99
543
2.42
9.68
2.4
1.6
22.07
21.40
nmol/l
0.18
89
462
107
627
2.30
8.80
8.2
6.4
—
—
—
0
0
92
522
2.25
8.01
3.5
2.8
333.27
340.80
umol/l
0.29
79
466
142
963
2.20
7.86
14.5
10.6
0.00
0.00
e9/l
0.82
119
775
17
23
7.88
7.83
2.2
1.5
—
—
—
0
0
50
218
2.64
7.77
3.7
4.6
6.00
5.75
kpa
1.16
50
210
49
215
2.62
7.51
3.7
4.7
7.35
7.39
ph
1.23
27
131
134
899
2.14
7.49
8.3
6.5
1.21
1.22
mmol/l
0.37
127
841
32
112
3.15
7.40
1.6
2.2
—
—
—
0
0
80
452
2.17
6.86
5.1
1.8
1.09
1.18
mg/l
0.16
65
346
44
191
2.60
6.86
3.3
3.8
4.11
4.53
kpa
0.82
44
184
125
839
2.05
6.74
2.5
2.0
87.60
97.09
pmol/l
1.91
74
426
140
994
2.01
6.29
8.0
7.3
1.21
1.21
mmol/l
0.35
126
869
17
44
4.09
6.10
1.4
1.2
6.00
4.32
u/ml
0.19
12
19
95
595
2.00
6.05
5.2
3.9
7.39
7.40
ph
0.74
75
413
192
1548
2.31
5.93
14.4
8.0
75.37
79.51
u/l
0.93
187
1464
52
262
2.26
5.82
7.5
8.1
104.17
104.19
mmol/l
0.01
52
262
68
385
2.08
5.66
3.2
2.7
2.43
2.45
mmol/l
0.51
59
346
41
191
2.39
5.47
7.3
10.0
—
—
—
0
0
44
213
2.31
5.38
7.0
8.9
0.87
0.79
mmol/l
0.04
37
180
16
44
3.83
5.30
1.7
2.7
1.38
1.48
ratio
—
9
18
44
217
2.26
5.15
6.6
8.8
7.42
7.42
ph
0.19
26
125
54
291
2.11
5.07
1.9
1.9
—
—
—
0
0
13
25
5.44
4.84
2.2
1.3
30.77
32.80
pg
0.40
13
25
43
216
2.21
4.80
7.0
8.8
5.08
5.14
kpa
0.18
43
208
43
216
2.21
4.80
7.0
8.7
13.69
12.89
kpa
0.29
43
209
10
14
7.40
4.70
1.4
1.4
—
—
—
0
0
37
176
2.31
4.70
7.1
8.5
1.22
1.30
mmol/l
0.24
37
171
54
302
2.02
4.57
3.2
2.3
29.74
29.29
s
0.21
54
297
32
145
2.40
4.52
8.5
9.9
25.48
24.81
mmol/l
0.46
32
145
11
19
6.02
4.50
1.2
1.4
—
—
—
0
0
41
209
2.16
4.41
3.8
2.5
28.72
30.68
u/l
0.29
36
170
17
56
3.19
4.33
1.5
1.3
—
—
—
0
0
44
236
2.06
4.15
1.4
1.7
—
—
—
0
0
20
75
2.82
4.11
1.5
1.6
13.27
7.37
u/l
0.72
15
58
78
509
1.80
4.09
1.5
1.4
2.43
2.37
g/l
0.07
50
313
50
284
1.97
4.02
5.4
6.2
1.05
1.09
mmol/l
0.42
50
262
24
101
2.53
3.96
4.7
4.7
—
—
—
0
0
77
506
1.78
3.92
6.2
4.5
—
—
—
0
0
50
291
1.91
3.74
1.8
1.5
784.00
574.12
titre
—
10
68
14
45
3.24
3.71
1.2
1.7
164.22
148.95
u/ml
—
9
20
14
45
3.24
3.71
1.5
1.5
—
—
—
0
0
118
885
1.67
3.66
14.4
11.1
1.26
1.18
inr
1.01
100
730
13
35
3.87
3.65
2.0
1.5
55.75
19.42
ng/l
0.68
13
35
49
286
1.90
3.63
1.5
1.7
—
—
—
0
0
98
707
1.66
3.49
3.8
3.3
2.38
2.36
mmol/l
0.80
87
653
7
10
7.17
3.38
2.6
1.9
11.86
10.50
umol/l
—
7
10
14
48
3.04
3.36
1.1
1.1
—
—
—
0
0
14
48
3.04
3.36
1.1
1.1
—
—
—
0
0
23
104
2.34
3.28
3.4
3.1
0.48
0.62
%
1.28
23
104
12
34
3.66
3.25
1.2
1.2
—
—
—
0
0
19
79
2.53
3.23
1.3
1.6
—
—
—
0
0
34
187
1.96
2.99
4.0
4.8
2.60
32.70
ug/l
0.70
26
150
74
515
1.64
2.95
7.8
4.0
—
—
—
0
0
6
9
6.80
2.88
1.0
1.1
—
—
—
0
0
43
259
1.81
2.87
1.4
1.3
—
—
—
0
0
31
170
1.95
2.75
1.3
1.7
—
—
—
0
0
59
394
1.66
2.74
1.7
1.8
—
—
—
0
0
6
10
6.12
2.71
2.7
2.3
383.83
1009.70
u/ml
—
6
10
16
67
2.49
2.69
1.1
1.2
—
—
—
0
0
13
49
2.75
2.67
2.1
3.1
63.27
60.12
%
0.17
13
49
90
671
1.55
2.64
3.7
3.2
11.73
147.67
e6/l
0.77
68
503
123
983
1.53
2.62
6.8
2.7
—
—
estimate
—
0
0
9
25
3.70
2.60
2.2
3.2
10.38
10.78
%
—
9
25
12
44
2.82
2.59
1.5
1.3
—
—
—
0
0
8
21
3.90
2.48
1.3
1.2
—
—
—
0
0
10
32
3.22
2.46
2.3
1.9
—
—
—
0
0
69
491
1.57
2.46
1.8
2.1
—
—
—
0
0
78
571
1.55
2.45
3.2
3.2
0.34
0.28
e6/l
0.19
55
405
5
8
6.36
2.38
1.0
1.3
162.00
159.50
mmol/24h
—
5
8
195
1752
1.66
2.26
33.4
17.8
14.69
13.49
%
10.54
195
1735
21
110
2.00
2.13
9.7
7.4
25.36
24.90
mmol/l
0.19
21
105
49
333
1.60
2.10
3.5
3.2
1.36
2.81
e6/l
0.97
25
164
37
234
1.69
2.09
1.6
1.4
—
—
—
0
0
9
31
2.98
2.09
1.0
1.7
—
—
—
0
0
6
15
4.08
2.05
1.2
1.1
—
—
—
0
0
28
168
1.76
1.91
13.1
8.0
8.77
7.96
mmol/l
0.21
28
163
53
375
1.53
1.91
2.5
2.8
486.01
542.95
mosm/kgh2o
1.07
45
325
8
28
2.92
1.88
1.8
1.6
—
—
—
0
0
8
28
2.92
1.88
1.8
1.6
—
—
—
0
0
8
28
2.92
1.88
1.8
1.6
—
—
—
0
0
8
28
2.92
1.88
1.8
1.6
—
—
—
0
0
96
768
1.42
1.86
4.9
4.0
94.50
57.36
e6/l
0.30
68
526
51
360
1.53
1.85
1.7
1.8
386.00
38742185.48
pmol/l
0.50
42
302
178
1591
1.49
1.85
4.7
4.5
14.69
14.66
pmol/l
0.05
163
1461
5
12
4.23
1.83
1.0
1.2
—
—
—
0
0
5
12
4.23
1.83
1.4
2.2
—
—
—
0
0
6
19
3.21
1.67
1.2
1.3
—
—
—
0
0
6
20
3.05
1.59
1.3
1.2
25.00
36.25
mg/l
—
6
15
58
434
1.45
1.58
2.9
2.7
4.04
5.36
e6/l
0.68
51
394
26
164
1.66
1.51
4.1
4.5
74.17
75.56
ng/l
0.04
21
146
9
38
2.42
1.47
1.0
1.1
—
—
—
0
0
90
736
1.36
1.46
4.4
3.6
23.57
43.00
ng/l
1.38
57
492
12
59
2.09
1.46
7.2
3.0
0.67
2.43
index
—
6
35
25
158
1.65
1.44
4.0
4.2
0.94
0.52
%
—
8
45
5
16
3.17
1.44
1.6
1.3
86.80
105.63
pmol/l
—
5
16
6
22
2.77
1.44
1.3
1.1
—
—
—
0
0
5
17
2.98
1.36
3.0
2.6
32.88
41.76
%
—
5
17
84
686
1.35
1.36
6.8
2.3
—
—
—
0
0
18
106
1.76
1.34
3.1
2.2
7295.86
2044.73
u/l
—
7
34
49
367
1.42
1.33
3.4
3.3
66.43
445.22
ng/l
2.12
37
268
216
2050
1.66
1.32
27.4
14.3
21.12
22.37
mg/l
0.32
190
1665
71
568
1.36
1.31
1.3
1.3
0.72
1.52
u/ml
1.14
14
163
20
123
1.68
1.29
1.3
1.5
22.28
23.45
iu/l
0.05
12
102
191
1771
1.42
1.28
37.6
18.5
337.84
332.98
g/l
4.53
191
1765
10
50
2.04
1.18
1.2
1.2
—
—
—
0
0
26
176
1.54
1.16
1.5
1.4
—
—
—
0
0
69
832
0.76
1.13
2.9
3.1
—
—
—
0
0
14
81
1.77
1.11
2.3
1.9
—
—
—
0
0
25
170
1.53
1.10
4.4
4.2
0.64
0.66
%
—
7
55
5
22
2.30
1.04
1.0
1.5
—
—
—
0
0
5
22
2.30
1.04
1.2
1.3
—
—
—
0
0
7
34
2.09
1.03
1.0
1.1
—
—
—
0
0
93
800
1.27
0.99
2.3
2.1
—
—
—
0
0
52
414
1.33
0.98
1.4
1.3
12.48
29.04
iu/ml
2.59
12
132
23
158
1.51
0.98
4.6
4.2
0.00
0.17
%
—
5
41
24
167
1.49
0.96
5.3
4.2
0.00
0.05
%
—
5
38
7
37
1.92
0.95
2.0
2.1
6.69
7.33
pmol/l
—
7
37
6
28
2.17
0.92
4.3
1.6
—
—
—
0
0
6
32
1.90
0.82
1.0
1.3
—
—
—
0
0
14
90
1.59
0.80
2.6
2.4
—
—
—
0
0
6
34
1.78
0.77
13.2
2.0
5.78
5.10
kpa
—
6
34
6
34
1.78
0.77
13.2
2.0
5.17
2.56
mmol/l
—
6
24
6
34
1.78
0.77
13.2
2.0
8.02
8.63
kpa
—
6
34
7
38
1.87
0.74
1.9
3.6
4.36
9.87
umol/l
—
7
29
78
889
0.82
0.74
2.3
2.0
1.28
1.40
mmol/l
0.53
67
755
35
276
1.32
0.72
1.3
1.2
—
—
—
0
0
47
387
1.27
0.71
1.4
1.3
10.07
8.36
u/ml
0.12
25
144
13
85
1.56
0.70
1.8
1.7
—
—
—
0
0
7
41
1.73
0.70
1.7
1.9
—
—
—
0
0
22
162
1.40
0.69
3.2
4.4
7.21
7.35
ph
0.70
16
128
29
224
1.34
0.69
1.3
1.5
—
—
—
0
0
5
92
0.53
0.68
1.0
1.1
1.43
1.55
g/l
—
5
92
16
224
0.69
0.68
1.4
1.4
—
—
—
0
0
5
95
0.52
0.68
1.0
1.2
0.85
0.88
g/l
—
5
95
10
62
1.64
0.66
11.2
12.7
—
—
—
0
0
75
656
1.21
0.65
2.0
1.5
—
—
—
0
0
37
299
1.28
0.65
4.7
2.5
116.27
92.88
ug/g
0.28
31
235
8
49
1.65
0.62
11.4
2.2
7.43
7.41
ph
—
8
49
59
506
1.22
0.62
4.0
3.7
1.02
1.02
kg/l
0.16
38
330
195
1869
1.25
0.62
4.0
4.1
1.30
1.28
mmol/l
0.11
179
1736
12
80
1.53
0.61
2.4
1.4
—
—
—
0
0
98
886
1.18
0.59
3.6
3.5
6.29
6.21
ph
0.29
49
496
6
36
1.68
0.57
8.2
1.5
—
—
—
0
0
14
100
1.43
0.53
1.4
2.2
8.02
4.30
iu/ml
—
5
27
15
109
1.40
0.52
1.3
1.2
—
—
—
0
0
55
625
0.84
0.49
3.7
2.9
0.00
0.01
estimate
0.50
24
172
25
304
0.80
0.44
1.5
1.6
—
—
—
0
0
216
2112
1.28
0.42
21.4
12.5
—
—
—
0
0
13
96
1.37
0.42
1.3
1.5
—
—
—
0
0
5
32
1.57
0.42
3.4
3.0
5.25
4.48
e9/l
—
5
32
5
33
1.53
0.41
1.4
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
203
1976
1.20
0.39
4.9
5.0
4.21
4.66
mmol/l
8.34
194
1862
40
348
1.18
0.38
2.9
2.8
0.55
0.76
ug/l
1.16
22
199
64
580
1.14
0.36
3.5
3.0
—
—
—
0
0
116
1095
1.12
0.34
4.1
3.7
0.00
0.00
estimate
-0.00
28
220
15
187
0.79
0.33
1.3
1.8
2.77
3.55
mmol/l
—
9
137
6
47
1.28
0.32
1.5
1.4
1.32
0.97
nmol/l
—
6
41
10
75
1.35
0.30
2.3
5.6
0.79
0.86
%
—
10
68
73
675
1.12
0.30
3.7
3.4
7.20
8.14
mmol/l
0.85
65
579
7
55
1.28
0.30
2.9
2.6
62.84
59.19
%
—
7
55
66
609
1.12
0.28
4.2
3.7
0.00
0.01
estimate
0.50
26
202
17
140
1.23
0.28
1.2
1.3
—
45.76
—
0
5
19
159
1.21
0.27
2.1
2.5
—
14.49
—
0
9
116
1105
1.10
0.27
4.2
3.7
0.00
0.00
estimate
-0.00
28
221
193
1886
1.13
0.26
6.1
5.3
1.89
1.88
mu/l
0.04
183
1759
117
1117
1.09
0.26
4.2
3.8
0.00
0.00
estimate
-0.00
27
209
9
73
1.24
0.26
1.3
1.2
—
—
—
0
0
203
1992
1.14
0.24
5.6
5.5
2.52
2.73
mmol/l
2.78
194
1868
201
1973
1.13
0.23
4.8
4.9
1.29
1.46
mmol/l
9.87
189
1850
0
11
0.00
0.21
0.0
3.2
—
40.40
—
0
6
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
61
572
1.09
0.19
4.7
4.8
1.50
1.81
ug/l
0.63
55
520
10
120
0.83
0.17
1.4
1.1
—
—
—
0
0
25
225
1.12
0.17
2.1
1.8
—
—
—
0
0
14
120
1.18
0.16
4.1
3.9
—
—
—
0
0
8
70
1.15
0.16
1.4
1.4
—
—
—
0
0
64
607
1.07
0.16
4.2
4.1
6.42
11.33
mg/mmol
0.97
42
378
8
73
1.10
0.16
1.6
1.5
—
—
—
0
0
14
121
1.17
0.15
1.4
1.5
—
—
—
0
0
18
160
1.14
0.14
4.0
3.4
—
—
—
0
0
10
84
1.20
0.14
3.0
5.3
1.69
1.68
%
—
10
77
63
602
1.06
0.13
3.9
3.4
36.00
71.44
mg/l
1.28
42
393
14
123
1.15
0.13
1.4
1.5
—
—
—
0
0
14
123
1.15
0.13
1.4
1.5
—
—
—
0
0
14
123
1.15
0.13
1.4
1.5
—
—
—
0
0
16
179
0.89
0.12
2.5
2.2
6.05
6.13
ph
—
10
119
22
201
1.10
0.12
1.0
1.1
—
—
—
0
0
13
115
1.14
0.10
1.5
1.5
—
—
—
0
0
6
55
1.09
0.09
2.0
1.8
—
—
—
0
0
6
55
1.09
0.09
1.0
1.3
—
—
—
0
0
6
56
1.07
0.08
1.5
1.4
198.13
314.73
ug/g
—
6
32
8
94
0.85
0.07
1.1
1.2
—
—
—
0
0
187
1856
1.04
0.05
6.6
5.9
35.21
38.68
mmol/mol
4.10
171
1755
26
271
0.95
0.04
1.5
1.4
—
—
—
0
0
83
840
0.98
0.02
3.8
3.5
0.00
0.01
estimate
0.50
23
185
191
1901
1.03
0.02
5.5
4.8
6.09
5.85
mmol/l
1.39
182
1768
15
143
1.05
0.01
1.6
1.2
—
—
—
0
0
14
146
0.96
0.00
1.5
1.5
638.78
1021.22
mu/l
—
8
124
27
276
0.98
0.00
1.6
1.8
—
—
—
0
0
11
108
1.02
0.00
1.2
1.1
—
—
—
0
0
11
112
0.98
0.00
2.1
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
0.00
—
0
8
6
68
0.88
-0.00
1.5
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
2331.25
—
0
8
0
5
0.00
-0.00
0.0
6.0
—
4.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
2.83
—
0
6
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
8
84
0.95
-0.00
2.5
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.8
—
15.40
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.02
—
0
6
0
5
0.00
-0.00
0.0
5.6
—
4.64
—
0
5
6
60
1.00
-0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
55.20
—
0
5

Mortality – FinRegistry

Association

Association between endpoint D3_HEREDHAEMOLYTICANAEMIAOTHER and mortality.

Females

Parameter HR [95% CI] p-value
D3_HEREDHAEMOLYTICANAEMIAOTHER 2.308 [1.7, 3.13] < 0.001
Birth year 0.997 [0.99, 1.01] 0.442

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 731 females with D3_HEREDHAEMOLYTICANAEMIAOTHER died.

Males

Parameter HR [95% CI] p-value
D3_HEREDHAEMOLYTICANAEMIAOTHER 2.124 [1.51, 2.99] < 0.001
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 684 males with D3_HEREDHAEMOLYTICANAEMIAOTHER died.

Mortality risk

Mortality risk for people of age

years, who have D3_HEREDHAEMOLYTICANAEMIAOTHER.

N-year risk Females Males
1 0.155% 0.381%
5 1.246% 2.119%
10 3.404% 5.639%
15 6.755% 10.52%
20 11.738% 17.51%

Relationships between endpoints

Index endpoint: D3_HEREDHAEMOLYTICANAEMIAOTHER – Other hereditary haemolytic anaemias

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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