Hereditary spherocytosis

D3_HERESPHERO

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D58.0 Hospital discharge: ICD-9 — 2820A Hospital discharge: ICD-8 — 2820 Cause of death: ICD-10 — D58.0 Cause of death: ICD-9 — 2820A Cause of death: ICD-8 — 2820 2 out of 7 registries used, show all original rules.	109
4. Check minimum number of events None	109
5. Include endpoints None	109
6. Filter based on genotype QC (FinnGen only)	101

Control definitions (FinnGen only)

Control exclude: D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D58
Name in latin: Sphaerocytosis hereditaria

NAME	D3_HERESPHERO
CONTROL_EXCLUDE	D3_HAEMOLYTICANAEMIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D580
HD_ICD_9	2820A
HD_ICD_8	2820
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D580
COD_ICD_9	2820A
COD_ICD_8	2820
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hereditary spherocytosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1328	648	674
Only index persons	1089	542	547
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	12.11	13.89	10.13
Only index persons	13.65	15.91	11.41

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	101	58	43
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	25.98	24.70	27.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
104: Matched controls
1040

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D58.0

ICD-10 Finland

Hereditary spherocytosis

+∞

90.1

28200

ICD-8 Finland

Hereditary haemolytic anaemias, Familial acholuric jaundice

+∞

36.6

2820A

ICD-9 Finland

Hereditary haemolytic anaemias, Hereditary spherocytosis

+∞

19.4

JMA11

NOMESCO Finland

Laparoscopic total splenectomy

+∞

11.7

JMA10

NOMESCO Finland

Transabdominal total splenectomy

97.6

8.5

JKA21

NOMESCO Finland

Laparoscopic cholecystectomy

4.3

7.0

K80.2

ICD-10 Finland

Calculus of gallbladder without cholecystitis

4.1

6.5

O99.1

ICD-10 Finland

Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium

+∞

6.3

6753

FHL

Transabdominal splenectomy

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023520) Reticulocytes [#/volume] in Blood

9.22

25.49

6.2

3.0

169.96

72.62

e9/l

7.59

(3000093) Morphology [Interpretation] in Blood Narrative

19.95

9.71

1.4

1.6

—

(3001604) Monocytes [#/volume] in Blood

465

3.20

6.78

7.7

6.5

0.77

0.57

e9/l

2.62

407

(3006315) Basophils [#/volume] in Blood

467

3.17

6.69

7.7

6.5

0.06

0.04

e9/l

5.01

407

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

8.33

6.67

1.8

1.7

—

(3013115) Eosinophils [#/volume] in Blood

484

3.12

6.38

7.9

7.2

0.21

0.19

e9/l

0.32

431

(3013650) Neutrophils [#/volume] in Blood by Automated count

525

3.27

6.35

10.2

5.15

4.01

e9/l

2.68

459

(3019198) Lymphocytes [#/volume] in Blood

479

3.03

6.17

7.8

6.5

2.25

1.93

e9/l

1.65

428

(42870588) Differential panel, method unspecified - Blood

296

2.51

5.05

8.1

6.6

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

115

2.68

4.14

2.2

3.0

34.56

23.88

2.02

108

(3024561) Albumin [Mass/volume] in Serum or Plasma

347

2.16

3.62

8.6

5.5

38.18

36.70

g/l

0.87

331

(3021960) Folate [Moles/volume] in Serum or Plasma

230

2.20

3.53

2.6

1.7

23.19

22.90

nmol/l

0.04

201

(3021589) Normoblasts [#/volume] in Blood

417

2.04

3.12

10.0

9.6

0.00

e9/l

0.56

336

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

6.16

3.07

1.3

1.1

109.43

89.58

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

346

2.01

3.03

2.7

2.0

94.52

97.40

pmol/l

0.21

179

(40758558) Short blood count panel - Blood

276

2.03

3.02

4.2

5.8

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

3.84

2.87

1.6

5.3

135.90

165.18

—

(4195642) Thrombophilia screening test

5.27

2.78

1.0

1.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.02

2.75

1.6

2.3

—

(3022145) Colonoscopy Study observation

2.41

2.59

1.8

1.3

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

641

2.07

2.53

11.5

7.9

73.12

80.27

u/l

1.54

603

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

372

1.87

2.50

6.1

6.8

1.22

mmol/l

0.06

348

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.53

2.45

2.3

6.0

24.49

23.94

mmol/l

0.32

(3012544) pH of Venous blood

2.25

2.34

2.2

6.3

7.36

7.39

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

180

1.94

2.25

2.0

2.3

1.30

0.84

mg/l

0.67

140

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

3.52

2.23

1.3

2.2

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.88

2.14

1.4

4.7

94.30

101.22

—

(3036489) Thrombin time

2.88

2.14

1.5

4.1

21.30

19.52

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.18

2.11

9.3

8.6

104.83

104.37

mmol/l

0.15

(3009214) Lutropin [Units/volume] in Serum or Plasma

2.73

2.00

1.1

1.4

13.52

5.75

u/l

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

3.50

2.00

1.1

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.27

1.98

2.7

2.8

10.99

10.22

g/l

0.43

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

4.71

1.96

1.0

1.2

—

(3026493) Urate [Moles/volume] in Serum or Plasma

215

1.78

1.89

2.2

2.9

341.96

337.74

umol/l

0.09

193

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.33

1.87

1.4

1.6

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.68

1.86

1.0

1.4

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

3.68

1.86

1.0

1.1

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.68

1.86

1.0

1.4

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

4.32

1.84

1.4

1.3

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

3.19

1.83

1.0

1.4

—

(3034770) Mitochondria Ab [Titer] in Serum

3.19

1.83

1.4

1.3

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

297

1.69

1.79

2.9

3.2

2.38

2.36

mmol/l

0.49

273

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.10

1.76

1.3

1.9

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

402

1.65

1.71

6.2

7.7

1.21

1.22

mmol/l

0.60

345

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

393

1.65

1.70

2.6

2.9

75.26

nmol/l

0.00

359

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.93

1.68

1.4

1.7

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.93

1.68

1.3

1.7

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.46

1.64

1.5

2.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

3.69

1.63

1.2

1.1

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.12

1.60

1.8

2.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

225

1.68

1.58

5.2

4.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

2.70

1.54

1.3

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

2.70

1.54

1.3

1.1

—

(4268621) Lupus anticoagulant assay

3.45

1.54

2.0

—

(3044290) Cell count panel - Cerebral spinal fluid

2.97

1.53

1.3

1.4

—

(3019060) Gas panel - Arterial blood

2.50

1.50

3.3

4.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.90

1.45

1.8

1.7

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.97

1.44

8.2

8.1

5.34

5.09

kpa

0.73

(3019977) pH of Arterial blood

1.97

1.44

8.2

8.1

7.41

7.43

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.86

1.37

1.7

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

2.06

1.34

1.4

1.5

9.98

25.20

iu/l

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.14

1.30

2.6

3.9

0.39

0.65

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.39

1.30

1.3

1.4

—

(3032080) INR in Blood by Coagulation assay

365

1.52

1.28

8.9

10.2

1.23

1.15

inr

0.62

292

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.15

1.26

10.4

10.2

0.83

0.62

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

404

1.51

1.26

5.1

2.8

—

estimate

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

102

1.80

1.25

1.6

2.4

—

(3030467) Casts [#/volume] in Urine by Automated count

239

1.56

1.22

2.3

3.7

0.18

0.20

e6/l

0.09

177

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

144

1.67

1.21

1.5

1.9

344.77

466.92

pmol/l

2.02

118

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.11

1.21

10.5

10.0

2.12

1.45

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.57

1.16

2.2

1.8

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

2.57

1.16

6.6

3.9

6.80

7.91

u/ml

—

(3007164) IgA [Mass/volume] in Serum or Plasma

233

1.54

1.15

1.5

2.58

2.46

g/l

0.10

143

(3042936) Bacteria identified in Isolate by Culture

113

1.72

1.15

2.1

1.7

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.45

1.10

1.2

1.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.20

1.08

1.4

1.8

—

2.20

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.76

1.07

1.4

2.2

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

2.00

1.05

1.7

1.9

—

(3000991) Gas panel - Venous blood

1.75

1.00

7.6

10.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.01

0.99

1.1

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

102

1.67

0.97

1.1

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.73

0.97

8.1

6.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.80

0.95

1.3

1.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

215

1.48

0.95

3.0

2.4

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.83

0.94

1.4

1.3

—

(3002582) Erythrocytes [#/volume] in Urine

290

1.43

0.91

2.4

3.7

11.04

43.40

e6/l

0.89

223

(1761868) Lipid panel - Serum or Plasma

372

0.69

0.87

1.9

3.1

—

(3011288) Drugs identified in Urine by Screen method Nominal

1.84

0.86

1.8

1.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

174

0.59

0.86

1.5

1.6

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

682

1.42

0.82

3.7

4.4

14.56

14.64

pmol/l

0.12

623

(3000492) Spirometry study

1.60

0.81

1.3

1.4

—

(3002256) Pathology report gross observation

116

1.56

0.80

1.1

1.2

—

(3023368) Bacteria identified in Blood by Culture

214

1.42

0.78

5.3

4.0

—

(40768797) Stomach Pathology biopsy report

117

1.54

0.78

1.5

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

144

1.48

0.75

1.7

2.0

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.69

0.75

6.5

11.9

25.15

24.59

mmol/l

0.21

(3018095) Leukocytes [#/volume] in Urine

329

1.35

0.72

3.7

4.8

142.91

24.45

e6/l

0.55

231

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

155

1.44

0.70

1.3

13.37

5.82

u/ml

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.89

0.69

7.2

4.2

4561.44

1411.27

u/ml

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

147

1.45

0.68

2.7

3.8

0.83

2.64

e6/l

1.26

(3012095) Magnesium [Moles/volume] in Serum or Plasma

156

1.43

0.68

3.0

4.4

0.83

0.80

mmol/l

0.79

148

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.82

0.67

2.2

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.82

0.67

1.0

1.5

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.82

0.67

1.0

1.2

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

663

1.34

0.64

5.6

4.1

11.61

9.55

mm/h

0.53

616

(36304419) Bacteria [Presence] in Urine

240

1.35

0.64

2.4

3.4

—

estimate

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

252

1.33

0.59

1.7

2.2

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.59

0.0

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

198

1.35

0.56

1.6

1.8

—

(4035726) Immunohistochemistry procedure

1.54

0.56

1.2

1.4

—

(3003694) ABO and Rh group [Type] in Blood

292

1.30

0.56

1.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

100

0.58

0.55

2.7

1.7

—

(40768804) Tissue Pathology biopsy report

341

1.28

0.54

2.1

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.57

0.54

2.8

4.9

54.03

48.99

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

146

1.37

0.51

1.5

1.8

—

(3044640) Blood type and Crossmatch panel - Blood

296

1.27

0.50

3.1

2.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.56

0.49

1.7

5.2

126.86

127.61

g/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.46

0.47

1.0

1.6

—

(3008898) HLA-B27 [Presence]

1.46

0.47

1.3

1.1

—

(3009261) Glucose [Presence] in Urine by Test strip

474

1.24

0.46

3.2

4.0

0.00

estimate

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.49

0.44

1.0

1.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

467

1.23

0.43

3.2

3.9

0.00

estimate

—

(3020891) Body temperature

1.59

0.43

6.2

4.2

36.12

36.94

°c

—

(3018418) pH of Serum or Plasma

235

1.26

0.42

3.6

3.9

7.39

0.11

170

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

152

1.31

0.40

2.7

3.7

0.55

0.83

e6/l

0.38

(3035350) Ketones [Presence] in Urine by Test strip

470

1.21

0.39

3.2

3.9

0.00

estimate

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

797

1.28

0.39

3.0

4.0

1.24

1.28

mmol/l

0.17

737

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.39

0.0

3.5

—

17.39

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

286

1.23

0.37

2.9

3.4

24.18

41.02

ng/l

0.46

178

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.36

0.37

4.5

2.2

434.00

387.22

nmol/l

0.76

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

258

1.23

0.36

1.3

0.68

1.18

u/ml

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

365

0.82

0.36

2.2

1.9

1.21

1.41

mmol/l

0.68

312

(3041096) Erythrocytes [Presence] in Urine by Automated

282

0.81

0.36

2.1

3.0

0.00

estimate

—

(3015736) pH of Urine

375

1.20

0.35

3.2

3.8

6.18

6.32

0.29

205

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

241

1.22

0.34

1.7

—

(36660697) Celiac disease serology panel - Serum

1.34

0.33

1.0

1.1

—

(3019225) pH of Specimen

1.37

0.31

3.2

4.9

7.38

7.36

—

(3019150) Specific gravity of Urine by Refractometry

215

1.21

0.30

2.9

3.9

1.02

kg/l

0.12

137

(3020682) Albumin/Creatinine [Ratio] in Urine

225

0.81

0.30

4.1

4.3

6.53

14.36

mg/mmol

0.79

135

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

131

1.26

0.29

3.3

2.5

0.85

0.70

ug/l

—

(3016879) Cocaine [Presence] in Urine

1.29

0.28

1.3

1.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

602

1.16

0.27

4.9

4.7

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

115

1.25

0.25

3.6

7.8

1.09

1.17

mmol/l

0.54

104

(40761511) CBC panel - Blood by Automated count

915

1.28

0.24

16.0

12.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.37

0.24

1.4

1.6

—

(40768443) Skin Pathology biopsy report

1.37

0.24

1.0

1.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.33

0.23

1.0

2.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

156

0.81

0.23

1.6

1.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.30

0.23

1.8

2.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.26

0.23

1.2

1.4

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.2

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

118.67

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

17.4

—

1822.60

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.21

0.0

1.0

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.21

0.0

1.5

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

5.6

—

92.52

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

1.6

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.6

—

97.14

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

3.2

—

(21494755) Public health laboratory ask at order entry panel

1.24

0.20

1.5

1.3

—

(3012516) Albumin [Mass/volume] in Urine

227

0.85

0.20

3.6

3.5

25.83

105.64

mg/l

1.74

140

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

2.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.19

0.20

1.5

1.3

—

(1002224) Polysomnography panel

1.16

0.19

1.5

1.1

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

157

1.18

0.19

4.2

3.2

98.33

253.32

ng/l

0.64

106

(44816559) Phosphatidylethanol [Mass/volume] in Blood

1.22

0.18

2.1

1.5

—

0.44

—

(3000764) Benzodiazepines [Presence] in Urine

1.21

0.17

1.3

1.6

—

(3028300) Cannabinoids [Presence] in Urine

1.17

0.17

1.3

1.6

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.17

0.17

1.0

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.17

0.17

1.6

1.2

143.13

360.95

u/ml

—

(3027008) Opiates [Presence] in Urine

1.17

0.17

1.3

1.6

—

(3027944) Amphetamines [Presence] in Urine

1.17

0.17

1.3

1.6

—

(3045414) Leukocytes [Presence] in Urine

1.12

0.16

2.1

1.8

—

0.00

estimate

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

171

1.14

0.13

4.2

4.4

23.36

21.92

—

(3026008) Bacteria identified in Urine by Culture

250

0.90

0.12

3.3

3.1

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

780

0.90

0.12

5.1

5.3

29.82

38.00

mmol/mol

9.56

741

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

198

0.89

0.12

1.7

2.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.80

0.08

1.2

1.4

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

0.82

0.08

1.2

1.3

—

105.52

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.03

0.07

3.3

3.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

181

0.93

0.05

1.7

2.2

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

900

1.09

0.04

20.5

13.6

18.79

21.50

mg/l

0.57

718

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

769

1.06

0.04

24.8

17.0

14.42

13.40

4.09

762

(3000494) Fungus identified in Specimen by Culture

111

1.09

0.04

1.2

1.4

—

(3013512) EKG study

251

1.05

0.03

3.2

—

(3029937) Albumin [Presence] in Urine by Test strip

251

1.05

0.03

2.7

3.8

0.00

estimate

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

359

0.96

0.02

2.7

3.6

0.00

0.01

estimate

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

682

1.03

0.02

4.4

3.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

151

0.99

0.00

1.4

1.8

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

32.76

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

1.4

—

10.20

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

2.8

—

111.17

—

(3020491) Glucose [Moles/volume] in Blood

0.00

-0.00

0.0

1.3

—

5.84

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.8

—

53.50

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.7

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.5

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.3

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(44806071) Cardiolipin IgM antibody measurement

0.00

-0.00

0.0

1.2

—

(40761536) Microorganisms panel - Urine sediment

0.96

-0.00

2.3

3.1

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.3

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

11.1

—

994.11

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

2.0

—

7.59

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

0.33

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.86

-0.00

4.4

4.2

1.28

1.23

mmol/l

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

1679.67

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

2.4

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

2.7

—

(21494815) CD4 cells/Lymphocytes in Specimen

0.00

-0.00

0.0

2.0

—

44.81

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3014043) Spermatozoa Nonprogressive/Spermatozoa in Semen

0.00

-0.00

0.0

6.0

—

4.60

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

142.20

—

(3025941) Bacteria identified in Stool by Culture

0.86

-0.00

1.2

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.5

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

2.2

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

2.6

—

0.71

—

(3045716) Anion gap in Serum or Plasma by calculation

0.00

-0.00

0.0

2.4

—

10.56

—

(40761995) Spermatozoa Progressive [#/volume] in Semen

0.00

-0.00

0.0

3.0

—

55.20

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

1.1

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(3033306) Mononuclear cells/Leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3022313) Gas panel - Capillary blood

0.93

-0.00

2.2

4.9

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.5

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

213.83

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

10.13

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_HERESPHERO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_HERESPHERO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: D3_HERESPHERO – Hereditary spherocytosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hereditary spherocytosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints