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Benign neoplasm: Appendix

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_APPENDIX

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D12.1&
  • Hospital discharge: ICD-8 — 21131
  • Cause of death: ICD-10 — D12.1&
  • Cause of death: ICD-8 — 21131

2 out of 7 registries used, show all original rules.

442

4. Check minimum number of events

None

442

5. Include endpoints

None

442

6. Filter based on genotype QC (FinnGen only)

397

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D12
Name in latin
Neoplasma benignum appendicis vermiformis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2109 1194 910
Only index persons 1983 1129 854
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 65.07 63.69 66.86
Only index persons 64.78 63.24 66.80

-FinnGen-

Key figures

All Female Male
Number of individuals 397 218 179
Unadjusted period prevalence (%) 0.08 0.08 0.08
Median age at first event (years) 65.81 63.52 68.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
411
Matched controls
4110
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D12.1
ICD-10 Finland
Benign neoplasm: Appendix
+∞
307.7
400
*
JEA01
NOMESCO Finland
Laparoscopic appendectomy
23.1
134.8
106
61
UJF32
NOMESCO Finland
Coloscopy
8.5
104.1
273
774
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
21.8
94.6
74
41
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
10.7
53.2
62
67
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
7.0
50.0
87
152
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
7.1
46.4
78
131
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
8.2
38.7
55
76
D37.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Appendix
214.8
38.5
39
*
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
8.9
37.9
50
63
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
7.1
37.5
61
98
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
11.9
35.1
37
34
UJF30
NOMESCO Finland
Ileoscopy through colon
4.5
32.9
96
261
JFB31
NOMESCO Finland
Laparoscopic right hemicolectomy
10.7
26.8
30
30
8480/1-C18.1
ICD-O-3
Low grade appendiceal mucinous neoplasm of appendix
+∞
23.1
22
*
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
9.6
22.3
27
30
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.9
20.2
131
578
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.7
17.6
122
553
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
16.7
168
906
8240/3-C18.1
ICD-O-3
Neuroendocrine tumor, NOS, of appendix
176.9
16.6
17
*
JFB30
NOMESCO Finland
Right hemicolectomy
7.6
15.8
23
32
WX402
NOMESCO Finland
General anaesthesia
2.5
14.9
118
565
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
3.5
14.7
56
179
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
14.1
177
1034
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.1
13.5
39
103
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
13.4
138
738
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
3.8
13.2
43
124
C18.19
ICD-10 Finland
Malignant tumor in appendix other or unspecified histology
+∞
12.6
12
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.0
12.3
61
228
JAH01
NOMESCO Finland
Laparoscopy
4.2
12.2
33
83
B01AB05
ATC
enoxaparin; parenteral
2.1
11.8
167
1005
K35.1
ICD-10 Finland
Acute appendicitis with peritoneal abscess
11.0
11.4
21
20
JN3AD
NOMESCO Finland
Abdominal CT examination
2.5
11.0
77
344
K38.9
ICD-10 Finland
Disease of appendix, unspecified
112.8
10.5
11
*
21131
ICD-8 Finland
Benign neoplasm of other parts of digestive system, Appendicis
+∞
10.5
10
*
P01AB01
ATC
metronidazole; oral, rectal
2.0
9.9
185
1213
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
9.9
73
334
JEA00
NOMESCO Finland
Appendectomy
3.4
9.5
35
109
C18.11
ICD-10 Finland
Malignant tumor of the appendix invasive carcinoma
102.3
9.5
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
9.4
113
632
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.4
8.8
67
310
JFB21
NOMESCO Finland
Laparoscopic ileocaecal resection
91.9
8.4
9
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.4
8.4
64
296
K63.5
ICD-10 Finland
Polyp of colon
4.4
8.3
21
50
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
3.2
8.2
33
109
Z2221
NOMESCO Finland
Medical doctor
1.9
8.0
125
762
B01AB10
ATC
tinzaparin; parenteral
2.4
7.9
60
276
JFB20
NOMESCO Finland
Ileocaecal resection
13.4
7.9
13
10
R4110
NOMESCO Finland
Physiotherapy
1.9
7.8
133
832
C18.10
ICD-10 Finland
Malignant tumor of the appendix without histology
45.9
7.7
9
*
JN4AD
NOMESCO Finland
Body CT examination
2.3
7.6
64
309
A02BC05
ATC
esomeprazole; systemic
1.8
7.5
183
1275
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
4.2
7.4
20
50
D37.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Colon
6.8
7.2
17
26
JFA45
NOMESCO Finland
Endoscopic contact coagulation in colon
20.4
7.2
10
5
WX704
NOMESCO Finland
Intubation
2.6
7.0
40
161
N02BE01
ATC
paracetamol; systemic, rectal
2.7
6.9
379
3358
D06
ICPC
Abdominal pain localized other
2.5
6.9
45
193
WX002
NOMESCO Finland
Sedation and analgesia
1.9
6.8
95
554
K92.1
ICD-10 Finland
Melaena
2.9
6.8
33
122
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
6.8
104
626
JAL20
NOMESCO Finland
Excision or destruction of lesion of peritoneum
22.9
6.7
9
*
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
2.6
6.6
37
148
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
3.4
6.5
23
70
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
6.4
218
1643
ZXD35
NOMESCO Finland
Usual procedure
3.7
6.4
20
56
A02BC02
ATC
pantoprazole; systemic
1.8
6.4
297
2438
JFB51
NOMESCO Finland
Other laparoscopic resection of colon
+∞
6.3
6
*
WX110
NOMESCO Finland
Infiltration anesthesia
1.8
6.2
290
2373

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
150
447
4.71
47.25
4.0
4.2
3.71
35.64
ug/l
1.14
124
378
146
457
4.40
42.59
1.6
1.3
—
—
—
0
0
57
174
3.64
16.13
3.9
2.9
66.66
1993.55
u/ml
1.18
48
148
260
1728
2.37
15.66
6.4
4.8
35.04
35.49
g/l
0.69
252
1634
258
1730
2.32
14.91
3.5
2.8
—
—
estimate
—
0
0
197
1224
2.17
13.20
3.0
2.5
—
—
—
0
0
101
489
2.41
12.21
1.3
1.3
—
—
—
0
0
159
935
2.14
12.01
2.8
2.3
—
—
—
0
0
196
1256
2.07
11.70
7.6
6.1
—
—
—
0
0
102
518
2.29
10.94
1.4
1.3
—
—
—
0
0
216
1467
2.00
10.65
2.6
2.2
—
—
—
0
0
350
2866
2.49
10.16
11.7
8.4
81.96
79.09
u/l
0.57
337
2694
77
359
2.41
9.98
3.1
2.5
32.75
32.12
u/l
0.07
67
301
18
17
11.01
9.87
2.0
4.0
59.06
66.53
nmol/l
0.43
18
17
243
1753
1.94
9.69
8.0
6.5
9.25
8.93
%
0.85
235
1652
274
2062
1.99
9.61
8.8
6.6
12.27
11.52
umol/l
0.54
268
1962
245
1780
1.93
9.48
8.0
6.5
26.40
26.99
%
0.37
237
1691
242
1753
1.93
9.43
8.0
6.4
2.89
2.84
%
0.13
234
1646
242
1753
1.93
9.43
8.0
6.5
0.62
0.67
%
0.87
233
1643
88
447
2.23
9.32
3.5
2.8
6.29
7.87
umol/l
0.81
79
392
114
642
2.07
9.27
2.6
2.6
2.40
2.29
g/l
1.17
107
591
278
2124
1.95
9.06
13.3
9.9
4.37
4.16
e9/l
0.74
238
1857
118
687
2.01
8.69
2.7
2.7
12.53
12.58
umol/l
0.03
111
639
106
594
2.06
8.67
2.7
2.7
21.57
22.00
%
0.13
99
555
227
1639
1.86
8.64
14.4
11.8
0.00
0.00
e9/l
0.37
183
1349
240
1766
1.86
8.57
7.8
6.3
58.21
57.67
%
0.27
232
1685
286
2243
1.90
8.16
6.5
5.0
6.59
6.71
mmol/l
0.55
273
2143
201
1432
1.79
7.68
5.6
4.2
44.15
97.29
e6/l
1.40
146
1030
255
1963
1.79
7.35
8.3
6.5
0.20
0.19
e9/l
0.14
222
1709
226
1683
1.76
7.28
3.5
3.1
129.27
133.17
ug/l
0.10
218
1559
249
1908
1.77
7.25
8.1
6.3
0.04
0.04
e9/l
0.09
210
1629
388
3465
3.14
7.24
26.1
17.5
26.83
24.52
mg/l
0.69
340
2901
182
1280
1.76
7.11
4.5
3.6
35.46
89.29
e6/l
0.50
139
990
247
1897
1.76
7.04
8.1
6.3
0.61
0.59
e9/l
0.48
209
1618
250
1929
1.76
6.99
8.1
6.4
1.72
1.94
e9/l
2.00
219
1699
70
367
2.09
6.73
2.5
2.3
0.22
0.21
g/l
0.02
64
342
244
1882
1.73
6.71
21.7
14.8
1.30
1.26
inr
0.49
208
1574
150
1025
1.73
6.32
4.2
3.4
—
0.00
estimate
—
0
5
158
1101
1.71
6.17
5.4
4.4
—
—
—
0
0
102
630
1.82
6.04
4.4
3.1
1.17
2.01
e6/l
1.33
53
314
251
1984
1.68
6.01
8.8
7.2
1.20
1.21
mmol/l
1.20
225
1718
157
1112
1.67
5.66
4.4
3.4
1.17
0.47
e6/l
0.51
113
827
93
569
1.82
5.65
2.4
1.9
—
—
—
0
0
16
43
3.83
5.42
1.1
1.0
—
—
—
0
0
228
1789
1.62
5.36
7.7
6.2
1.20
1.21
mmol/l
1.76
215
1637
144
1010
1.66
5.33
3.1
2.2
2.62
2.95
mg/l
1.31
134
868
104
670
1.74
5.27
4.1
3.3
0.83
0.82
mmol/l
0.42
96
630
283
2349
1.66
5.24
4.2
3.4
64.51
50.02
u/l
0.54
278
2190
171
1258
1.62
5.20
4.1
3.2
30.62
32.07
u/l
0.32
159
1183
69
398
1.88
5.02
3.7
3.5
7.37
7.38
ph
1.00
40
238
115
777
1.67
4.85
4.6
4.2
64.82
291.42
ng/l
2.34
103
628
215
1693
1.57
4.77
2.6
2.5
77.51
78.52
nmol/l
0.21
195
1506
69
408
1.83
4.64
3.7
3.5
6.01
5.79
kpa
0.73
63
392
88
565
1.71
4.46
8.6
6.5
104.50
103.97
mmol/l
0.56
88
565
119
827
1.62
4.45
3.9
2.9
2.47
2.46
mmol/l
0.41
105
744
393
3656
2.71
4.44
17.0
12.9
25.50
25.31
u/l
0.08
387
3554
80
501
1.74
4.43
2.7
2.8
1.84
1.80
%
0.11
74
452
66
391
1.82
4.40
3.8
3.5
1.44
2.05
mmol/l
0.51
55
332
112
773
1.62
4.29
3.8
3.3
518.05
530.52
mosm/kgh2o
0.24
99
678
162
1222
1.54
4.21
3.7
3.4
—
—
—
0
0
219
1762
1.52
4.21
2.4
2.2
91.33
95.62
pmol/l
0.72
118
933
60
350
1.84
4.21
1.4
1.5
—
—
—
0
0
152
1136
1.54
4.10
8.8
6.4
—
—
—
0
0
397
3729
2.90
4.06
39.0
26.7
248.59
245.85
e9/l
0.33
391
3660
397
3731
2.88
4.01
39.0
26.7
6.70
6.76
e9/l
0.25
390
3653
397
3731
2.88
4.01
39.0
26.6
4.39
4.45
e12/l
1.34
389
3653
132
963
1.55
3.94
1.4
1.4
—
—
—
0
0
175
1364
1.49
3.80
4.5
3.4
2.34
2.35
mmol/l
0.77
162
1231
357
3249
1.75
3.65
5.8
5.6
1.96
1.95
mu/l
0.02
344
2969
124
906
1.53
3.64
3.2
2.9
4.18
4.92
e6/l
0.51
111
831
380
3532
2.01
3.52
23.0
15.6
—
—
—
0
0
71
458
1.67
3.51
8.3
7.6
7.40
7.41
ph
0.51
35
282
70
453
1.66
3.42
8.2
7.6
0.62
1.14
mmol/l
0.48
56
383
67
436
1.64
3.20
2.5
2.3
153.43
137.86
ug/g
0.09
57
349
12
35
3.50
3.13
1.1
1.3
—
—
—
0
0
103
745
1.51
3.12
3.5
3.2
0.74
0.81
ug/l
0.26
73
483
54
337
1.69
3.02
11.0
8.1
—
—
—
0
0
66
444
1.58
2.76
2.1
1.6
—
—
—
0
0
59
387
1.61
2.74
9.6
8.2
122.46
120.38
g/l
0.32
59
382
46
285
1.69
2.66
1.7
2.4
—
—
—
0
0
227
1954
1.36
2.46
4.8
4.2
0.00
0.00
estimate
-0.00
54
403
150
1213
1.37
2.41
5.5
4.1
7.40
7.40
ph
0.11
109
863
14
59
2.42
2.31
1.1
1.0
—
—
—
0
0
6
13
4.67
2.28
1.0
1.4
—
—
—
0
0
227
1972
1.34
2.23
4.9
4.2
0.00
3.90
estimate
0.50
54
416
56
384
1.53
2.17
3.1
2.9
76.14
69.53
e9/l
0.63
38
293
11
42
2.66
2.16
1.2
1.4
—
—
—
0
0
11
42
2.66
2.16
1.3
1.7
—
—
—
0
0
371
3506
1.60
2.12
6.3
6.3
2.56
2.66
mmol/l
1.36
354
3229
31
184
1.74
2.11
1.5
1.9
1.41
1.51
g/l
0.28
24
168
228
1992
1.32
2.10
4.9
4.3
0.00
0.80
estimate
0.52
53
389
10
37
2.74
2.08
1.2
1.3
—
—
—
0
0
25
140
1.84
2.06
2.2
2.1
282.60
303.55
ug/l
0.06
25
131
16
76
2.15
2.05
1.1
1.2
10.22
8.42
u/l
—
10
59
35
217
1.67
2.05
1.1
1.2
151.97
125.38
u/ml
0.11
13
80
8
26
3.12
2.02
1.9
1.2
—
—
—
0
0
107
843
1.36
1.98
1.9
1.7
1.24
1.35
mg/l
0.19
88
670
361
3409
1.48
1.87
5.4
5.6
6.04
6.02
mmol/l
0.08
341
3120
37
240
1.60
1.83
1.3
1.4
—
—
—
0
0
33
208
1.64
1.83
2.6
2.6
—
—
—
0
0
91
709
1.36
1.80
1.9
1.7
1068.18
1173.31
nmol/l
0.45
72
539
70
523
1.41
1.77
1.5
1.3
480.00
507.88
titre
0.06
16
132
61
446
1.43
1.74
1.5
1.5
—
—
—
0
0
48
335
1.49
1.73
1.6
1.5
—
—
—
0
0
34
220
1.59
1.71
11.3
8.9
16.61
15.77
%
1.04
34
214
11
49
2.28
1.65
1.2
1.5
31.75
31.71
g/l
0.00
11
43
52
373
1.45
1.65
1.4
1.5
—
—
—
0
0
20
113
1.81
1.63
4.2
2.8
1.65
1.58
mg/l
0.20
20
99
26
159
1.68
1.63
1.9
3.0
—
—
—
0
0
181
1570
1.27
1.63
4.1
3.8
6.24
6.21
ph
0.15
88
891
175
1519
1.26
1.55
4.5
4.2
31.93
92.85
ng/l
0.86
129
1156
121
1004
1.29
1.53
3.5
2.9
367.47
349.55
umol/l
0.99
110
880
355
3368
1.40
1.53
7.3
7.0
39.30
39.83
mmol/mol
0.54
340
3153
12
59
2.06
1.45
1.3
1.1
—
—
—
0
0
153
1317
1.26
1.43
3.4
3.3
1099.68
1347.60
ng/l
0.57
134
1129
67
517
1.35
1.41
1.5
1.7
—
—
—
0
0
41
290
1.46
1.41
2.6
2.5
10.96
13.39
nmol/l
1.50
35
264
88
708
1.31
1.40
1.2
1.3
18.59
34.38
iu/ml
2.33
28
229
19
112
1.73
1.38
1.5
1.2
—
—
—
0
0
6
23
2.63
1.37
1.2
1.0
—
—
—
0
0
5
17
2.96
1.36
1.2
1.1
—
—
—
0
0
5
17
2.96
1.36
1.6
2.3
785.40
790.71
u/ml
—
5
17
18
107
1.71
1.28
4.4
3.0
1.83
2.22
index
0.18
12
63
91
746
1.28
1.26
1.6
1.4
2.55
2.62
g/l
0.10
58
437
140
1211
1.24
1.23
2.0
1.7
20.23
20.79
nmol/l
0.19
128
1006
8
37
2.18
1.22
1.0
1.5
20.75
31.60
ng/l
—
8
37
17
101
1.71
1.21
1.2
1.1
—
—
—
0
0
19
117
1.65
1.20
1.5
1.4
177.86
286.70
ug/g
—
9
69
12
64
1.90
1.19
1.2
1.1
—
—
—
0
0
8
38
2.13
1.19
1.1
1.1
—
—
—
0
0
0
36
0.00
1.14
0.0
1.1
—
—
—
0
0
14
80
1.78
1.14
1.9
1.5
—
—
—
0
0
359
3445
1.33
1.14
5.4
5.5
4.48
4.59
mmol/l
1.16
344
3194
34
244
1.43
1.12
3.1
4.6
—
—
—
0
0
43
322
1.37
1.11
2.2
2.8
14.26
7.80
ug/l
0.34
36
285
21
136
1.57
1.11
1.3
1.3
—
—
—
0
0
357
3427
1.32
1.10
5.2
5.4
1.44
1.48
mmol/l
0.81
345
3153
79
648
1.27
1.09
1.3
1.3
17.81
11.80
u/ml
0.25
23
252
10
180
0.54
1.09
2.7
3.8
—
—
—
0
0
99
835
1.24
1.08
1.5
1.3
1.46
1.43
u/ml
0.02
22
207
60
476
1.31
1.07
1.6
1.4
—
—
—
0
0
36
264
1.40
1.06
1.4
1.4
—
—
—
0
0
26
179
1.48
1.06
2.0
2.0
—
—
—
0
0
13
75
1.76
1.04
1.2
1.2
—
—
—
0
0
35
257
1.40
1.03
1.8
1.6
0.88
1.31
g/l
2.18
35
235
9
47
1.94
1.02
2.8
1.8
—
—
—
0
0
142
1251
1.21
1.02
6.5
5.7
2.29
2.83
ug/l
0.46
128
1119
27
190
1.45
0.99
1.3
1.3
—
—
—
0
0
34
250
1.39
0.99
4.9
7.1
24.13
24.85
mmol/l
0.64
34
241
13
77
1.71
0.96
1.8
1.4
—
—
—
0
0
149
1333
1.18
0.89
3.4
3.4
7.65
7.40
mmol/l
0.30
121
1115
8
42
1.92
0.89
1.5
1.2
—
—
—
0
0
20
136
1.49
0.88
1.8
3.2
374.67
234.64
mg/l
—
9
45
6
30
2.01
0.87
1.3
3.0
522.50
930.60
mg
—
6
30
8
44
1.83
0.86
1.1
1.9
—
—
—
0
0
290
2748
1.19
0.85
4.7
4.5
14.79
14.87
pmol/l
0.22
275
2494
38
295
1.32
0.82
2.8
2.4
6.13
6.11
ph
0.03
24
206
10
58
1.74
0.80
4.2
2.2
33.50
32.97
pg
—
10
58
16
107
1.52
0.77
4.7
6.9
1.22
1.22
mmol/l
0.00
16
97
341
3291
1.21
0.75
4.4
4.6
1.31
1.27
mmol/l
0.47
322
3003
6
106
0.56
0.73
1.3
1.4
—
—
—
0
0
5
26
1.93
0.71
3.4
3.2
1.60
0.85
index
—
5
26
25
188
1.35
0.68
2.8
2.4
0.11
0.02
estimate
—
9
55
97
859
1.17
0.65
4.5
4.4
1.02
1.02
kg/l
0.24
70
582
14
95
1.49
0.65
5.6
2.7
102.00
85.43
ug/min
—
8
57
17
121
1.42
0.63
1.0
1.1
—
—
—
0
0
146
1336
1.14
0.63
4.2
4.2
10.00
9.77
mg/mmol
0.02
91
832
14
96
1.47
0.62
1.4
1.2
—
—
—
0
0
35
281
1.27
0.62
5.7
4.2
—
—
—
0
0
141
1296
1.13
0.56
3.5
3.4
46.94
54.51
mg/l
0.19
87
829
35
286
1.24
0.55
1.2
1.2
—
—
—
0
0
6
38
1.59
0.54
2.3
1.9
84.65
90.23
%
—
6
38
165
1535
1.13
0.54
2.0
2.0
1.36
1.34
mmol/l
0.13
142
1269
142
1311
1.13
0.53
3.0
3.5
—
—
—
0
0
6
40
1.51
0.52
1.2
1.1
—
—
—
0
0
6
40
1.51
0.52
2.2
2.4
—
—
—
0
0
24
190
1.28
0.49
1.3
1.3
—
—
—
0
0
12
165
0.72
0.47
1.1
1.1
—
—
—
0
0
42
357
1.20
0.47
2.9
2.2
0.00
0.04
estimate
—
10
76
7
50
1.41
0.45
4.9
2.5
3.34
4.62
e9/l
—
7
50
11
78
1.42
0.43
4.5
3.4
—
—
—
0
0
32
379
0.83
0.42
1.6
1.6
—
—
—
0
0
5
33
1.52
0.41
2.6
2.4
—
27.05
—
0
6
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
3.8
—
13.62
—
0
16
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
2.6
—
65.33
—
0
12
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
28
233
1.22
0.40
1.2
1.3
—
—
—
0
0
8
61
1.32
0.39
1.6
1.3
—
—
—
0
0
10
71
1.42
0.39
2.4
3.7
9.22
9.66
pmol/l
—
10
71
15
116
1.30
0.37
1.9
1.5
6361.00
14998.87
e6/l
—
9
83
6
42
1.43
0.35
1.2
1.1
—
—
—
0
0
6
47
1.28
0.32
1.2
1.2
—
—
nmol/l
—
0
0
16
129
1.25
0.30
2.6
3.2
1.47
2.90
ratio
—
7
71
10
75
1.34
0.30
2.1
1.5
—
—
—
0
0
13
103
1.27
0.28
5.3
10.3
—
—
—
0
0
18
149
1.22
0.28
1.9
1.4
0.25
0.35
mg/l
—
9
64
8
63
1.28
0.28
2.4
1.6
—
—
—
0
0
8
63
1.28
0.28
3.1
3.3
—
—
—
0
0
114
1076
1.08
0.27
4.5
3.7
0.02
0.08
estimate
0.34
48
322
21
178
1.19
0.26
1.1
1.1
—
—
—
0
0
87
813
1.09
0.26
4.1
5.4
—
—
—
0
0
10
77
1.31
0.26
2.1
1.5
—
—
—
0
0
87
815
1.09
0.25
1.6
1.8
446.85
17308133.68
pmol/l
0.50
75
676
9
74
1.22
0.25
1.7
1.2
3.20
3.88
mmol/l
—
9
68
13
106
1.23
0.23
4.2
5.7
—
—
—
0
0
5
38
1.32
0.23
3.0
1.9
—
—
—
0
0
12
97
1.24
0.23
1.2
1.1
0.91
0.91
g/l
0.02
12
97
5
40
1.25
0.22
3.2
1.7
—
—
—
0
0
10
79
1.27
0.22
2.1
1.5
—
—
—
0
0
10
79
1.27
0.22
2.1
1.5
—
—
—
0
0
155
1491
1.06
0.22
4.7
4.2
0.05
0.04
estimate
0.07
44
334
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
6
48
1.25
0.20
1.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
55.50
—
0
14
6
49
1.23
0.20
1.3
1.1
—
10.44
—
0
12
6
49
1.23
0.20
1.0
1.2
—
—
—
0
0
10
81
1.24
0.19
2.2
1.5
—
—
—
0
0
13
152
0.85
0.17
1.4
1.2
—
2.76
—
0
10
35
379
0.92
0.15
2.9
2.0
397.31
388.52
nmol/l
0.12
35
353
9
78
1.16
0.15
1.2
1.2
95.09
20.13
u/l
—
9
66
36
333
1.09
0.15
4.9
5.1
0.00
0.16
%
—
9
103
115
1112
1.05
0.14
4.9
4.3
0.00
0.01
estimate
0.50
52
376
36
335
1.08
0.13
4.5
4.9
0.90
0.57
%
—
10
110
5
45
1.11
0.10
1.2
1.1
—
—
—
0
0
10
87
1.15
0.09
1.1
1.2
—
—
—
0
0
6
54
1.11
0.09
1.2
1.2
0.55
0.59
nmol/l
—
6
49
35
369
0.94
0.08
3.6
4.3
7.39
7.36
ph
1.40
28
256
7
67
1.05
0.08
1.9
1.3
—
—
—
0
0
15
137
1.10
0.07
1.6
1.5
67.05
9.84
u/ml
—
6
21
8
74
1.08
0.07
1.8
1.2
14.25
25.87
e6/l
—
8
54
8
75
1.07
0.07
4.3
2.4
59.25
59.45
%
—
8
75
7
84
0.83
0.07
1.6
1.3
43.43
60.75
mmol/l
—
7
75
25
265
0.94
0.07
1.4
1.4
—
—
—
0
0
9
87
1.04
0.07
1.7
1.2
403.22
513.30
mg/l
—
9
82
23
216
1.07
0.07
1.5
1.9
3.62
3.50
mmol/l
0.16
16
163
13
142
0.91
0.06
1.5
1.8
—
—
—
0
0
37
355
1.05
0.06
4.8
5.0
0.80
0.90
%
—
10
125
10
91
1.10
0.04
1.1
1.1
1.39
1.54
g/l
—
10
91
34
351
0.97
0.03
5.3
5.4
0.14
0.15
%
—
7
97
16
169
0.94
0.03
1.9
2.0
9.02
8.32
iu/ml
—
6
41
20
208
0.96
0.02
1.4
1.7
—
—
—
0
0
10
94
1.07
0.01
1.1
1.8
—
—
—
0
0
6
63
0.95
0.00
1.7
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
6
63
0.95
0.00
1.7
1.7
—
—
—
0
0
6
63
0.95
0.00
1.7
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
6
63
0.95
0.00
1.7
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
4.7
—
7.58
—
0
6
0
6
0.00
0.00
0.0
1.3
—
1.90
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
0.02
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
57.60
—
0
5
7
74
0.95
-0.00
1.1
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
18.30
—
0
8
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_APPENDIX and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_APPENDIX 1.145 [0.93, 1.41] 0.206
Birth year 0.999 [0.99, 1.01] 0.73

During the follow-up period (1.1.1998 — 31.12.2019), 186 out of 979 females with CD2_BENIGN_APPENDIX died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_APPENDIX 1.264 [1.04, 1.54] 0.019
Birth year 0.984 [0.97, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 219 out of 743 males with CD2_BENIGN_APPENDIX died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_APPENDIX.

N-year risk Females Males
1 0.116% 0.274%
5 0.71% 1.536%
10 1.883% 3.573%
15 3.424% 6.429%
20 5.936% 10.78%

Relationships between endpoints

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Index endpoint: CD2_BENIGN_APPENDIX – Benign neoplasm: Appendix

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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