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Isolated patent ductus arteriosus

Endpoint Browser PheWeb

Q17_PDA

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q25.0
  • Hospital discharge: ICD-9 — 7470A
  • Hospital discharge: excluded ICD-10 — Q2[0-4]|Q26|Q90|Q91|Q92|Q93|Q96|Q8780|Q8781|Q8782|Q8783|Q8784|Q8786|Q8788|Q85|Q796|Q874|Q875
  • Hospital discharge: excluded ICD-9 — 758|7595|75683
  • Cause of death: ICD-10 — Q25.0
  • Cause of death: ICD-9 — 7470A
  • Cause of death: excluded ICD-10 — Q2[0-6]|Q90|Q91|Q92|Q93|Q96|Q8780|Q8781|Q8782|Q8783|Q8784|Q8786|Q8788|Q85|Q796|Q874|Q875
  • Cause of death: excluded ICD-9 — 758|7595|75683

2 out of 7 registries used, show all original rules.

399

4. Check minimum number of events

None

399

5. Include endpoints

None

399

6. Filter based on genotype QC (FinnGen only)

367

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF7

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 367 254 113
Unadjusted period prevalence (%) 0.08 0.09 0.05
Median age at first event (years) 2.52 3.42 0.49

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
387
Matched controls
3819
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q25.0
ICD-10 Finland
Patent ductus arteriosus
8969.0
307.7
304
*
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
24.9
115.0
87
44
7470A
ICD-9 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
+∞
110.4
101
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
7.7
90.3
199
460
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
7.4
66.8
122
225
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
32.5
66.1
44
15
Q25.1
ICD-10 Finland
Coarctation of aorta
29.4
65.4
45
17
201
Kela drug reimbursment
Chronic cardiac insufficiency
16.7
65.2
58
40
XF400
NOMESCO Finland
ECG with 12 standard connections
5.8
60.6
155
392
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
14.3
54.9
53
42
FDE32
NOMESCO Finland
Percutaneous transluminal closure of patent ductus arteriosus
+∞
50.9
48
*
5512
FHL
Cleavage or ligation of the ductus arteriosus
+∞
48.8
46
*
FM2CE, ,
NOMESCO Finland
7.3
47.6
79
129
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.4
45.5
219
879
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
15.1
43.3
40
29
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
6.8
43.0
76
132
C01AA05
ATC
digoxin; systemic
17.7
42.6
36
22
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
7.9
39.0
58
83
XF404
NOMESCO Finland
Ambulatory ECG
6.5
35.4
64
113
XF600
NOMESCO Finland
Bloodpressure measurement
4.9
34.9
92
229
Q21.10
ICD-10 Finland
Persistent ostium secundum
8.5
32.9
45
58
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
11.4
32.2
35
33
B01AA03
ATC
warfarin; systemic
5.9
29.9
59
113
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
5.6
28.7
60
121
ZXD10
NOMESCO Finland
Scheduled procedure
3.2
28.3
192
893
ZXE10
NOMESCO Finland
More than one and less than three hours
3.2
26.9
170
753
XF402
NOMESCO Finland
ECG with work load test
6.3
25.6
46
80
31
HP
Congenital heart failure surgery
53.3
25.5
30
6
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
21.6
24.6
36
18
C03CA01
ATC
furosemide; systemic
4.1
24.0
78
224
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.0
22.0
137
590
74709
ICD-8 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
218.5
20.7
21
*
TPH07
NOMESCO Finland
Cathetrisation of artery
3.6
20.1
75
236
Z2221
NOMESCO Finland
Medical doctor
2.8
19.8
146
682
61
HP
Catheterization and pressure measurement of the left side of the heart
30.4
19.8
26
9
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
18.6
92
344
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
13.3
17.3
30
24
C03DA01
ATC
spironolactone; oral
4.2
16.8
48
124
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
16.3
137
673
ZXE20
NOMESCO Finland
More than three and less than five hours
3.2
15.4
68
236
Q23.11
ICD-10 Finland
Bicuspid aortic valve
14.6
15.1
25
18
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
+∞
14.6
14
*
FDE10
NOMESCO Finland
Ligature of patent ductus arteriosus
153.6
14.5
15
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
24.6
13.8
19
8
62
HP
Catheterization and pressure measurement of the right side of the heart
76.9
13.6
15
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.1
12.9
37
96
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
9.7
12.6
25
27
Z3231
NOMESCO Finland
Registered nurse
2.2
12.5
153
869
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
6.4
12.4
21
34
WX402
NOMESCO Finland
General anaesthesia
2.3
12.2
135
733
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
38.4
12.2
15
*
G04BE03
ATC
sildenafil; oral
27.3
12.1
16
6
UGC02
NOMESCO Finland
Rigid bronchoscopy
13.8
12.0
20
15
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
11.9
57
207
XFE00
NOMESCO Finland
Epicardial ultrasonography
11.5
11.6
21
19
UDC00
NOMESCO Finland
Ear microscopy
3.1
11.2
50
174
I50.9
ICD-10 Finland
Heart failure, unspecified
4.5
10.9
27
62
C07AB02
ATC
metoprolol; systemic
3.1
10.4
46
159
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
16.4
10.4
16
10
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
8.7
10.1
21
25
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
101.1
9.4
10
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
8.3
9.4
20
25
Q90.0
ICD-10 Finland
Trisomy 21, meiotic nondisjunction
22.1
9.3
13
6
TFP20
NOMESCO Finland
Cardiodefibrillation
5.3
9.3
19
37
ZXE40
NOMESCO Finland
More than seven and less than nine hours
4.8
9.2
21
45
R4110
NOMESCO Finland
Physiotherapy
2.0
9.1
124
718
R03BA02
ATC
budesonide; inhalant
2.3
9.0
81
399
RS224, ,
NOMESCO Finland
7.4
8.8
20
28
WX882
NOMESCO Finland
High dependency care
2.6
8.7
54
224
C01BD01
ATC
amiodarone; systemic
11.8
8.6
15
13
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
8.5
92
486
Q90.9
ICD-10 Finland
Down syndrome, unspecified
20.3
8.5
12
6
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
20.3
8.5
12
6
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
3.0
8.4
39
138
FLE96
NOMESCO Finland
Other repair of outlet obstruction of left ventricle
90.8
8.4
9
*
I27.0
ICD-10 Finland
Primary pulmonary hypertension
+∞
8.3
8
*
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
+∞
8.3
8
*
XF620
NOMESCO Finland
Examination of circulation with color method
33.7
8.1
10
*
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
17.4
8.1
12
7
RS221, ,
NOMESCO Finland
4.4
7.9
20
47
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
13.2
7.9
13
10
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
7.9
86
456
C07AB07
ATC
bisoprolol; oral
2.0
7.8
95
524
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
11.0
7.8
14
13
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
11.0
7.8
14
13
ZXE00
NOMESCO Finland
One hour or less
1.8
7.8
161
1062
XF622
NOMESCO Finland
Measurement of minute volume of heart
15.2
7.7
12
8
Q76.30
ICD-10 Finland
Hemivertebra fusion or failure of segmentation with scoliosis
45.3
7.7
9
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.5
7.7
49
206
K78
ICPC
Atrial fibrillation/flutter
4.6
7.6
18
40
J45.1
ICD-10 Finland
Nonallergic asthma
2.4
7.4
53
235
Q90
ICD-10 Finland
Down syndrome
80.5
7.4
8
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
7.4
80
422
7454A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM NUD]
+∞
7.3
7
*
7451A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[TRANSPOSITIO CORDIS COMPLETA]
+∞
7.3
7
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
15.9
7.2
11
7
Q21.30
ICD-10 Finland
Tetralogy of Fallot
15.9
7.2
11
7
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
30.2
7.1
9
*
Q21.21
ICD-10 Finland
Atrioventricular duct
30.2
7.1
9
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.1
7.1
82
442
Q26.1
ICD-10 Finland
Persistent left superior vena cava
20.2
7.1
10
5
Q20.48
ICD-10 Finland
Single ventricle
20.2
7.1
10
5
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
13.9
6.9
11
8
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
11.1
6.8
12
11
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.5
6.6
44
188
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
6.6
44
188
207
Kela drug reimbursment
Chronic arrhythmias
3.1
6.6
28
94
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.5
6.5
22
64
ZXD05
NOMESCO Finland
Urgent procedure
1.9
6.5
107
650
I35.0
ICD-10 Finland
Aortic (valve) stenosis
6.3
6.5
16
26
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
70.0
6.4
7
*
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
70.0
6.4
7
*
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
14.4
6.4
10
7
K84
ICPC
Heart disease other
8.3
6.3
13
16
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
18.1
6.2
9
5
5609
FHL
Other measure in this category
+∞
6.2
6
*
74719
ICD-8 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta
+∞
6.2
6
*
7454B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM SIMPLEX]
+∞
6.2
6
*
FMD40
NOMESCO Finland
Replacement of aortic root using pulmonary autograft and reimplantation of coronary arteries (Ross)
+∞
6.2
6
*
FDE96
NOMESCO Finland
Other closure of patent ductus arteriosus
+∞
6.2
6
*
R62.0
ICD-10 Finland
Delayed milestone
2.7
6.2
34
132
R03AK08
ATC
formoterol and beclometasone; inhalant
3.9
6.2
18
47
205
Kela drug reimbursment
Chronic hypertension
2.6
6.1
36
145
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
3.3
6.1
23
72
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
6.1
75
413
P85
ICPC
Mental retardation
4.2
6.0
16
39
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
4.2
6.0
16
39

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
149
469
4.47
42.64
7.7
5.6
1076.92
998.15
ng/l
0.14
135
389
140
528
3.53
29.33
5.9
6.4
31.99
30.43
s
1.83
140
522
194
900
3.26
28.83
24.0
9.1
1.38
1.14
inr
5.64
169
735
171
859
2.73
20.24
8.3
8.7
82.63
87.52
%
1.70
171
847
187
1009
2.60
18.81
3.1
3.4
—
—
—
0
0
162
820
2.63
18.53
3.1
3.3
—
—
—
0
0
221
1388
2.33
14.74
3.6
3.5
—
—
estimate
—
0
0
66
239
3.08
13.87
16.7
17.3
7.42
7.40
ph
0.41
25
106
64
240
2.95
12.60
16.9
17.2
-0.54
0.43
mmol/l
1.17
56
198
100
475
2.45
12.33
3.7
3.4
2.50
2.51
g/l
0.05
95
444
53
186
3.10
11.69
14.6
16.3
121.72
120.28
g/l
0.15
53
181
95
452
2.42
11.61
6.1
3.6
1166.47
952.08
ng/l
0.23
77
264
45
158
3.05
9.89
21.1
20.8
95.54
95.39
%
0.05
45
158
40
140
3.03
8.83
23.9
22.7
15.87
15.51
%
0.36
40
134
116
662
2.04
8.79
3.9
4.1
1.33
1.76
mg/l
0.37
76
513
103
566
2.08
8.63
3.8
3.2
—
—
—
0
0
73
353
2.28
8.41
16.5
14.8
105.86
105.41
mmol/l
0.36
73
353
113
657
1.98
8.04
4.4
4.5
—
—
—
0
0
57
253
2.43
7.95
5.4
7.4
22.98
22.18
s
0.38
52
245
193
1348
1.82
7.71
8.8
8.7
21.66
22.20
umol/l
0.06
182
1252
178
1240
1.77
6.95
1.6
1.8
—
—
—
0
0
31
116
2.78
6.09
12.5
20.4
65.31
68.92
%
0.55
31
116
15
25
6.11
5.99
8.6
3.5
5.03
4.86
kpa
0.31
15
25
15
25
6.11
5.99
8.6
3.5
6.07
6.16
kpa
0.14
15
25
349
3058
2.29
5.72
24.6
16.5
139.29
139.43
mmol/l
0.59
343
2992
348
3050
2.25
5.62
24.6
16.5
3.96
3.95
mmol/l
0.16
343
2969
158
1116
1.67
5.53
9.5
8.2
36.79
37.20
g/l
0.40
145
1075
40
180
2.33
5.40
9.6
15.7
0.67
0.59
%
0.82
40
180
61
329
1.98
5.22
1.4
1.6
—
—
—
0
0
69
391
1.90
5.11
2.2
2.1
—
—
—
0
0
25
94
2.74
4.89
1.3
2.0
1.56
1.14
g/l
0.73
18
85
29
118
2.54
4.87
10.4
19.7
65.73
69.29
%
0.52
29
118
136
949
1.64
4.86
4.2
3.3
2.94
2.44
mg/l
1.78
128
850
100
649
1.70
4.70
3.7
3.2
34.08
20.71
ng/l
0.43
62
333
195
1504
1.56
4.48
18.9
15.7
1.20
1.23
mmol/l
5.87
187
1430
47
244
2.03
4.47
1.7
1.6
925.39
1099.70
nmol/l
0.74
36
180
94
611
1.68
4.36
17.1
14.3
—
—
—
0
0
205
1606
1.55
4.35
17.3
14.3
1.21
1.23
mmol/l
3.91
189
1467
100
674
1.63
4.01
12.1
12.3
7.38
7.37
ph
1.79
72
436
21
82
2.61
3.85
5.4
9.7
—
—
—
0
0
361
3298
2.19
3.80
18.3
13.8
25.32
21.74
mg/l
1.16
291
2505
98
670
1.59
3.68
11.2
12.3
1.44
0.92
mmol/l
1.20
87
544
40
212
1.96
3.61
3.9
6.8
0.32
0.55
%
0.59
14
77
229
1882
1.49
3.59
12.5
8.8
5.89
6.09
mmol/l
1.26
216
1739
54
318
1.79
3.53
13.7
22.4
1.13
1.09
mg/l
0.19
54
312
38
202
1.95
3.41
2.6
3.5
0.08
0.17
e6/l
1.10
38
195
10
22
4.58
3.41
3.2
2.2
100.50
95.82
g/l
—
10
22
59
365
1.70
3.26
1.8
1.6
447.14
21406204.62
pmol/l
0.50
51
313
39
214
1.89
3.20
3.9
7.6
0.09
0.11
%
0.05
11
66
101
722
1.51
3.06
5.3
4.2
7.39
7.39
ph
0.29
76
492
17
68
2.53
3.00
1.1
1.3
2.70
3.90
u/ml
—
10
41
24
113
2.17
2.97
1.9
2.2
—
—
—
0
0
24
113
2.17
2.97
1.9
2.2
—
—
—
0
0
24
113
2.17
2.97
1.9
2.2
—
—
—
0
0
24
113
2.17
2.97
1.9
2.2
—
—
—
0
0
67
442
1.60
2.89
5.4
7.1
6.74
6.47
umol/l
0.10
57
357
183
1481
1.42
2.87
7.3
11.1
—
—
—
0
0
39
225
1.79
2.75
4.2
7.1
0.69
0.69
%
0.00
13
84
50
313
1.66
2.65
1.5
1.3
—
—
—
0
0
237
2031
1.39
2.54
8.8
6.7
101.45
109.92
u/l
0.88
227
1926
5
7
7.12
2.53
1.0
1.1
180.80
127.86
nmol/l
—
5
7
122
940
1.41
2.46
2.5
1.8
97.18
96.84
pmol/l
0.02
71
469
36
212
1.75
2.39
4.1
7.3
0.00
0.09
%
—
10
69
20
98
2.07
2.28
6.8
11.3
24.45
24.29
mmol/l
0.09
20
91
12
47
2.57
2.23
2.2
2.4
—
—
—
0
0
90
669
1.43
2.20
13.4
12.4
1.32
1.34
mmol/l
0.23
84
639
10
36
2.79
2.11
2.4
2.5
—
—
—
0
0
220
1896
1.34
2.09
7.1
10.4
0.63
0.64
%
0.01
213
1825
97
740
1.39
2.04
3.5
3.0
56.23
58.22
u/l
0.25
90
688
142
1152
1.34
2.02
3.8
4.5
25.92
44.24
e6/l
0.85
108
834
18
89
2.04
2.02
13.7
25.1
11.21
11.60
%
0.21
18
89
6
15
3.99
2.02
4.0
1.7
10.33
9.93
mmol/l
—
6
15
220
1902
1.33
2.01
7.0
10.3
2.79
3.07
%
1.07
212
1831
220
1904
1.32
1.99
7.1
10.4
8.73
8.34
%
1.54
212
1836
12
50
2.41
1.99
1.0
1.2
—
—
—
0
0
245
2154
1.33
1.98
10.1
12.7
3.67
3.73
e9/l
0.20
219
1789
224
1949
1.32
1.92
6.8
10.0
53.32
50.81
%
2.04
219
1904
5
11
4.53
1.92
1.2
1.1
32.76
36.60
g/l
—
5
11
10
39
2.57
1.92
1.1
1.2
92.50
117.28
pmol/l
—
10
39
45
299
1.55
1.91
9.5
8.7
70.15
56.63
ng/l
0.44
40
286
11
45
2.45
1.89
2.6
3.4
3.20
3.64
%
—
5
18
235
2067
1.31
1.82
7.8
10.9
0.19
0.20
e9/l
1.01
212
1740
82
620
1.39
1.81
2.0
1.5
21.56
21.26
nmol/l
0.06
73
544
5
12
4.15
1.80
1.0
1.2
—
—
—
0
0
9
35
2.57
1.78
11.3
4.8
5.91
7.08
mmol/l
—
9
35
234
2065
1.30
1.73
7.5
10.1
2.05
2.38
e9/l
3.40
214
1760
12
54
2.23
1.70
4.9
6.6
9.88
7.81
pmol/l
0.19
12
54
227
2002
1.29
1.65
7.6
10.1
0.04
0.04
e9/l
0.38
201
1647
94
737
1.34
1.65
21.6
18.8
25.44
24.61
mmol/l
2.08
94
737
227
2003
1.29
1.64
7.4
10.1
0.57
0.57
e9/l
0.14
202
1650
78
595
1.37
1.63
12.3
13.0
—
—
—
0
0
17
293
0.55
1.61
1.5
1.6
3.68
3.30
mmol/l
—
10
203
89
695
1.34
1.60
13.6
12.7
7.41
7.41
ph
0.13
73
538
225
1989
1.28
1.58
7.1
10.1
31.22
34.36
%
3.44
219
1932
108
872
1.31
1.54
3.6
2.9
2.35
2.39
mmol/l
1.93
100
813
18
100
1.81
1.50
1.9
4.8
14.28
9.40
%
0.96
18
100
12
58
2.08
1.46
4.1
2.0
2.54
6.23
ug/l
0.33
12
53
91
724
1.31
1.44
2.6
3.5
5.89
7.82
e6/l
0.56
83
640
6
22
2.72
1.41
2.7
2.8
4.02
3.92
mmol/l
—
6
22
10
46
2.18
1.37
12.8
4.4
1.41
1.30
mmol/l
—
10
46
124
1037
1.26
1.33
3.6
4.4
0.17
0.33
e6/l
1.38
85
724
92
741
1.30
1.33
5.8
5.3
—
—
—
0
0
39
275
1.44
1.29
1.3
1.2
—
—
—
0
0
66
510
1.33
1.28
3.3
5.0
327.18
305.07
umol/l
0.99
57
473
9
44
2.04
1.25
2.7
4.4
0.89
0.61
index
—
9
44
351
3332
1.43
1.22
17.1
10.4
—
—
—
0
0
11
195
0.54
1.18
1.0
1.0
7.58
7.34
kpa
0.19
11
172
11
195
0.54
1.18
1.0
1.0
—
—
—
0
0
145
1250
1.23
1.17
6.4
8.9
—
—
—
0
0
18
109
1.66
1.16
2.1
4.5
1264.15
1631.77
e6/l
0.84
13
74
11
193
0.55
1.15
1.0
1.0
3.05
3.27
kpa
0.41
11
170
10
50
2.00
1.13
2.5
3.1
18.72
24.55
mg/l
—
5
38
5
20
2.49
1.13
1.4
2.5
32.40
48.13
%
—
5
8
5
20
2.49
1.13
1.4
1.2
—
—
—
0
0
59
458
1.32
1.12
1.8
1.8
—
—
—
0
0
11
58
1.90
1.09
1.5
1.3
—
—
—
0
0
11
58
1.90
1.09
3.8
3.9
3.47
3.43
e9/l
0.03
11
58
11
58
1.90
1.09
7.7
5.9
—
—
—
0
0
7
33
2.11
1.05
1.4
2.7
30.14
32.03
pg
—
7
33
52
401
1.32
1.04
1.3
1.5
167.32
294.93
u/ml
0.87
47
376
5
22
2.26
1.02
3.0
2.8
102.40
105.73
mmol/l
—
5
22
5
22
2.26
1.02
3.0
2.8
1.22
1.20
mmol/l
—
5
22
5
22
2.26
1.02
4.0
6.5
236.40
197.95
ug/l
—
5
22
5
22
2.26
1.02
2.0
1.7
2.10
1.14
nmol/l
—
5
16
27
187
1.46
1.01
1.4
1.2
—
—
—
0
0
7
130
0.52
1.01
1.0
4.3
3.57
3.39
mmol/l
—
7
123
211
1910
1.20
0.99
5.2
3.8
64.03
62.18
ug/l
0.07
204
1823
7
35
1.99
0.99
2.1
2.5
—
—
—
0
0
24
163
1.48
0.99
1.5
1.5
0.38
0.20
mg/l
—
9
62
26
180
1.46
0.98
1.3
1.2
—
—
—
0
0
82
677
1.25
0.98
3.2
3.4
530.31
550.02
mosm/kgh2o
0.26
72
585
106
900
1.22
0.98
2.7
2.7
—
—
—
0
0
49
380
1.31
0.95
3.1
2.1
2.41
2.43
mmol/l
0.40
40
334
14
84
1.67
0.95
1.5
1.5
0.77
0.60
g/l
—
9
75
63
506
1.27
0.94
1.3
1.3
26.97
19.98
iu/ml
0.15
11
117
28
374
0.72
0.91
1.9
1.9
—
—
—
0
0
44
339
1.32
0.90
3.8
5.0
68.75
66.25
e9/l
0.17
31
213
12
70
1.71
0.90
1.0
1.1
—
—
—
0
0
10
55
1.82
0.89
9.0
13.3
1.05
1.29
mmol/l
—
10
46
26
349
0.72
0.87
1.9
1.9
—
—
—
0
0
207
1892
1.17
0.81
12.2
13.3
0.00
0.01
e9/l
0.47
173
1438
27
196
1.39
0.81
1.3
1.3
—
—
—
0
0
100
1123
0.84
0.80
3.8
3.1
—
0.25
—
0
8
11
65
1.69
0.80
3.2
4.2
6.95
8.80
kpa
1.92
11
65
29
376
0.74
0.80
1.9
1.9
—
—
—
0
0
0
26
0.00
0.78
0.0
1.3
—
21.80
—
0
5
0
26
0.00
0.78
0.0
1.3
—
20.14
—
0
7
86
977
0.83
0.78
2.7
2.4
—
—
—
0
0
29
373
0.75
0.76
1.9
1.9
—
—
—
0
0
81
687
1.21
0.76
3.8
4.0
2.14
2.19
e6/l
0.03
40
348
5
23
2.16
0.76
1.2
2.4
11.56
10.84
umol/l
—
5
23
155
1391
1.17
0.76
5.0
5.6
219.44
51.78
e6/l
0.42
108
881
29
372
0.75
0.75
1.9
1.9
—
—
—
0
0
6
107
0.55
0.73
1.2
1.2
—
—
—
0
0
10
59
1.69
0.73
1.6
1.3
5.33
6.13
g/l
—
5
52
6
109
0.54
0.73
1.2
1.2
—
3.82
—
0
15
284
2922
0.85
0.72
6.4
4.9
2.07
1.90
mu/l
1.36
272
2769
59
489
1.22
0.70
1.5
1.5
154.29
528.00
titre
—
7
80
11
68
1.61
0.69
4.6
6.2
—
—
—
0
0
5
27
1.84
0.68
1.0
1.2
—
—
nmol/l
—
0
0
40
321
1.26
0.64
1.5
1.4
67.70
139.39
u/ml
0.70
11
105
205
1896
1.14
0.63
4.8
4.4
37.37
31.88
u/l
0.86
197
1835
6
100
0.59
0.63
1.5
5.4
—
—
—
0
0
15
103
1.45
0.62
2.1
4.4
316.70
195.10
e6/l
—
10
68
27
207
1.31
0.61
2.1
1.7
—
—
—
0
0
0
19
0.00
0.60
0.0
1.4
—
—
—
0
0
15
104
1.44
0.60
1.7
5.1
22.53
15.71
%
0.66
15
104
14
96
1.46
0.59
1.4
4.7
22.79
25.25
%
0.41
14
96
32
253
1.27
0.58
2.5
2.0
0.00
0.00
estimate
—
7
76
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
36
290
1.25
0.57
1.7
1.4
—
—
—
0
0
8
54
1.47
0.56
11.8
8.7
9.56
10.66
mg/l
—
8
49
6
36
1.65
0.56
1.0
1.3
—
—
—
0
0
10
64
1.56
0.56
1.2
1.1
—
—
—
0
0
15
106
1.41
0.55
1.7
4.3
504.00
575.79
e6/l
—
10
68
32
256
1.25
0.54
4.1
4.0
—
—
—
0
0
25
308
0.79
0.51
1.9
1.9
—
—
—
0
0
11
154
0.70
0.51
1.2
1.2
—
—
—
0
0
18
134
1.34
0.50
3.7
4.5
—
—
—
0
0
11
153
0.70
0.49
1.2
1.2
—
—
—
0
0
14
100
1.40
0.49
2.2
4.7
34.41
37.14
%
0.27
14
100
23
282
0.79
0.46
1.0
1.3
2.25
0.70
u/ml
0.94
15
198
16
206
0.76
0.46
1.6
1.6
—
—
—
0
0
22
271
0.79
0.46
1.6
2.3
—
—
—
0
0
22
271
0.79
0.46
1.4
1.6
76.99
60.76
ug/l
0.45
17
241
14
102
1.37
0.45
1.8
1.3
283.11
347.25
ug/g
—
9
56
20
248
0.78
0.44
2.1
2.3
—
16.54
—
0
20
161
1493
1.11
0.44
4.9
3.5
69.93
70.91
nmol/l
0.17
149
1403
9
128
0.69
0.44
1.0
1.2
—
—
—
0
0
16
204
0.76
0.43
1.6
1.5
—
—
—
0
0
11
77
1.42
0.43
1.4
3.3
—
—
—
0
0
8
57
1.39
0.42
3.4
2.2
12.26
14.91
umol/l
—
8
57
0
15
0.00
0.41
0.0
1.3
—
0.00
—
0
15
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
28
229
1.22
0.41
1.8
2.0
6.29
6.33
ph
0.07
17
150
5
33
1.50
0.41
1.8
3.0
—
—
—
0
0
33
275
1.20
0.40
1.7
1.9
—
—
—
0
0
10
135
0.72
0.39
1.7
1.6
—
—
—
0
0
5
35
1.41
0.39
3.0
2.6
—
—
—
0
0
9
65
1.37
0.38
2.7
4.2
5.26
4.90
kpa
—
9
65
94
853
1.12
0.38
4.4
3.8
0.00
0.00
estimate
0.50
37
328
86
777
1.12
0.38
3.7
3.2
1.01
1.02
kg/l
1.02
60
508
43
484
0.86
0.38
1.5
1.6
1121.61
938.24
mu/l
0.51
33
430
8
111
0.71
0.37
1.1
1.1
—
—
—
0
0
8
114
0.69
0.37
1.1
1.2
—
—
—
0
0
8
114
0.69
0.37
1.5
1.7
—
6.55
—
0
30
25
205
1.22
0.36
1.2
1.1
—
—
—
0
0
34
288
1.18
0.36
2.4
2.2
11.51
13.12
iu/l
0.21
25
189
5
78
0.63
0.36
2.8
4.7
—
—
—
0
0
9
121
0.73
0.36
1.3
4.8
—
—
—
0
0
24
283
0.83
0.35
1.0
1.3
4.68
4.91
u/ml
0.05
17
217
376
3676
1.33
0.35
29.7
21.1
6.95
7.05
e9/l
0.38
365
3539
19
229
0.81
0.34
1.2
1.2
—
23.58
—
0
9
16
125
1.27
0.34
1.3
1.6
—
—
—
0
0
21
171
1.22
0.33
3.8
4.5
21.55
10.35
umol/l
0.76
15
138
327
3167
1.12
0.32
24.1
18.6
333.99
334.17
g/l
0.13
327
3156
19
227
0.82
0.32
1.1
1.4
406.39
255.28
miu/ml
2.15
11
112
16
195
0.80
0.32
1.5
1.5
1.15
1.25
mm
—
7
152
36
310
1.16
0.32
2.2
2.1
—
—
—
0
0
110
1020
1.09
0.30
2.0
2.0
1.30
1.29
mmol/l
0.05
97
916
375
3670
1.27
0.28
29.7
21.2
259.06
269.42
e9/l
2.19
365
3548
11
84
1.30
0.28
4.9
4.1
7.40
7.40
ph
0.04
11
84
32
277
1.15
0.28
2.3
2.2
7.17
7.37
u/l
0.03
21
167
9
118
0.75
0.27
1.0
1.3
—
—
—
0
0
124
1161
1.08
0.27
2.3
2.4
—
—
—
0
0
68
725
0.91
0.27
2.8
3.3
233.50
82.33
ug/g
0.64
53
592
8
66
1.20
0.26
3.9
6.0
3.38
2.35
ug/l
—
8
66
230
2204
1.07
0.26
5.5
4.6
36.01
36.86
mmol/mol
0.81
217
2091
127
1192
1.08
0.26
4.0
3.4
0.00
0.01
estimate
0.80
30
284
28
314
0.87
0.25
1.1
1.3
1.47
2.67
u/ml
0.40
20
225
6
81
0.73
0.24
1.2
4.6
—
—
—
0
0
375
3675
1.22
0.22
29.6
21.1
4.53
4.54
e12/l
0.16
363
3541
19
217
0.86
0.22
2.2
2.1
157.60
160.89
u/ml
—
10
102
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
—
—
0
0
5
42
1.18
0.21
1.0
1.0
—
—
—
0
0
8
104
0.75
0.21
3.9
2.3
0.72
0.56
nmol/l
—
8
93
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
90
937
0.93
0.21
2.0
1.8
—
—
—
0
0
47
503
0.91
0.21
3.7
3.7
92.07
87.37
mg/l
0.03
32
355
16
134
1.19
0.20
3.1
2.7
52.80
53.23
%
0.05
16
134
6
47
1.26
0.20
8.8
2.9
—
—
—
0
0
94
881
1.07
0.20
3.9
3.2
0.00
0.00
estimate
0.50
32
280
6
48
1.24
0.20
1.0
1.7
0.50
0.50
e9/l
—
6
48
6
48
1.24
0.20
1.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
55
583
0.92
0.20
1.4
1.3
—
—
—
0
0
47
499
0.92
0.18
4.8
4.4
18.82
43.61
mg/mmol
0.33
32
344
52
480
1.08
0.17
1.4
1.3
1.04
7.17
u/ml
2.58
25
162
181
1742
1.05
0.15
4.5
3.9
0.00
0.00
estimate
-0.00
38
335
18
200
0.88
0.15
1.1
1.1
—
—
—
0
0
34
363
0.92
0.15
1.5
1.6
—
—
—
0
0
12
101
1.18
0.15
1.4
4.7
0.43
0.45
e9/l
—
6
61
146
1482
0.96
0.14
3.7
3.5
6.43
6.30
ph
0.64
79
722
32
292
1.09
0.13
1.2
1.2
—
—
—
0
0
10
115
0.85
0.12
1.1
1.2
0.79
0.87
g/l
—
10
115
15
131
1.14
0.12
1.3
1.4
—
—
—
0
0
182
1760
1.04
0.12
4.6
3.9
0.00
0.00
estimate
-0.00
39
317
16
176
0.89
0.12
2.2
2.1
—
—
—
0
0
181
1751
1.04
0.11
4.5
3.9
0.00
4.91
estimate
0.50
39
331
39
362
1.07
0.11
2.9
2.5
10955.50
5016.73
u/l
0.32
12
146
35
367
0.94
0.10
1.8
1.9
—
—
—
0
0
14
123
1.13
0.10
5.2
3.0
28.86
36.70
u/ml
0.27
14
118
14
123
1.13
0.10
3.4
2.4
—
—
—
0
0
21
190
1.10
0.10
7.5
8.4
542.13
405.81
mg/l
0.17
15
140
5
43
1.15
0.10
11.6
2.2
—
—
—
0
0
128
1293
0.97
0.10
1.6
1.8
1.80
1.63
g/l
0.76
76
709
5
45
1.10
0.09
1.4
1.5
19415.40
23990.88
e6/l
—
5
32
243
2371
1.03
0.08
4.3
3.8
1.42
1.45
mmol/l
0.75
234
2236
42
396
1.05
0.08
1.1
1.4
—
124.41
—
0
17
6
72
0.82
0.07
1.2
1.9
—
—
—
0
0
9
83
1.07
0.07
1.3
1.2
—
—
—
0
0
13
117
1.10
0.06
1.5
1.2
—
—
—
0
0
42
430
0.96
0.06
1.3
1.3
—
55.83
—
0
6
245
2397
1.02
0.06
4.5
3.9
4.44
4.50
mmol/l
0.48
236
2274
83
837
0.97
0.05
2.0
2.0
—
—
—
0
0
15
137
1.08
0.05
2.1
2.0
24.87
19.98
ng/l
0.67
15
137
26
244
1.06
0.05
1.8
1.4
—
—
—
0
0
14
128
1.08
0.05
3.6
2.0
0.00
0.00
estimate
—
6
57
136
1358
0.98
0.04
1.6
1.8
0.50
3.99
u/ml
5.33
27
271
17
158
1.06
0.04
3.3
5.3
7.41
7.34
ph
0.53
12
114
90
901
0.98
0.03
5.0
4.6
6.35
8.06
mmol/l
2.44
80
830
98
980
0.98
0.03
1.7
1.9
—
—
—
0
0
242
2375
1.01
0.03
4.1
3.3
5.48
5.55
mmol/l
0.47
225
2180
325
3196
1.02
0.03
13.1
10.9
26.20
25.18
u/l
0.33
316
3112
226
2219
1.01
0.02
3.8
3.4
1.16
1.16
mmol/l
0.07
216
2089
243
2389
1.01
0.01
4.8
4.1
2.65
2.68
mmol/l
0.21
234
2261
19
181
1.04
0.01
2.4
2.1
102.43
103.70
au/ml
—
7
76
11
111
0.98
0.00
1.1
1.1
1.32
1.53
g/l
2.07
11
111
61
606
0.99
0.00
1.8
1.7
—
—
—
0
0
261
2574
1.00
0.00
5.2
4.2
14.68
14.55
pmol/l
0.39
243
2391
18
183
0.97
0.00
2.4
2.1
—
—
—
0
0
12
119
0.99
0.00
1.3
1.8
7.67
18.05
u/ml
—
7
82
0
8
0.00
-0.00
0.0
5.1
—
0.50
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
10.26
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
0.02
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
77.80
—
0
5
5
57
0.86
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
80
0.99
-0.00
2.4
2.6
—
22.94
—
0
5
8
79
1.00
-0.00
1.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
63.78
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
119.67
—
0
7
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
59
1.00
-0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
75
0.92
-0.00
1.3
1.3
—
—
—
0
0
5
58
0.85
-0.00
1.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: Q17_PDA – Isolated patent ductus arteriosus

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).