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Isolated patent ductus arteriosus

Endpoint Browser PheWeb

Q17_PDA

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q25.0
  • Hospital discharge: ICD-9 — 7470A
  • Hospital discharge: excluded ICD-10 — Q2[0-6]|Q90|Q91|Q92|Q93|Q96|Q8780|Q8781|Q8782|Q8783|Q8784|Q8786|Q8788|Q85|Q796|Q874|Q875
  • Hospital discharge: excluded ICD-9 — 758|7595|75683
  • Cause of death: ICD-10 — Q25.0
  • Cause of death: ICD-9 — 7470A
  • Cause of death: excluded ICD-10 — Q2[0-6]|Q90|Q91|Q92|Q93|Q96|Q8780|Q8781|Q8782|Q8783|Q8784|Q8786|Q8788|Q85|Q796|Q874|Q875
  • Cause of death: excluded ICD-9 — 758|7595|75683

2 out of 7 registries used, show all original rules.

101

4. Check minimum number of events

None

101

5. Include endpoints

None

101

6. Filter based on genotype QC (FinnGen only)

101

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF7

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1181 727 447
Only index persons 1000 622 378
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 1.27 1.23 0.69
Only index persons 1.02 1.17 0.78

-FinnGen-

Key figures

All Female Male
Number of individuals 101 72 29
Unadjusted period prevalence (%) 0.02 0.02 0.01
Median age at first event (years) 2.21 2.76 0.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
86
Matched controls
861
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
7470A
ICD-9 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
+∞
123.8
86
*
5512
FHL
Cleavage or ligation of the ductus arteriosus
+∞
42.2
37
*
Q25.0
ICD-10 Finland
Patent ductus arteriosus
+∞
15.0
14
*
C01AA05
ATC
digoxin; systemic
17.8
9.9
15
10
201
Kela drug reimbursment
Chronic cardiac insufficiency
16.4
9.1
14
10
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.6
6.9
20
44
74709
ICD-8 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
+∞
6.3
6
*
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
6.3
6
*
31
HP
Congenital heart failure surgery
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
39
218
2.29
3.75
5.5
4.9
37.34
37.77
g/l
0.20
34
209
34
185
2.26
3.44
3.4
2.8
2.35
2.36
mmol/l
0.22
27
163
29
148
2.35
3.40
2.8
3.2
7.38
7.41
ph
—
8
27
27
136
2.34
3.24
3.8
3.7
—
—
—
0
0
42
255
2.11
3.20
8.1
8.0
1.21
1.21
mmol/l
0.34
36
210
31
167
2.24
3.19
2.5
1.7
0.54
0.97
mg/l
1.54
19
110
22
106
2.37
2.90
1.4
1.7
408.71
465.60
pmol/l
0.57
17
92
11
39
3.04
2.57
2.0
2.9
2.65
1.43
mmol/l
0.62
11
29
11
39
3.04
2.57
2.0
2.9
6.15
5.80
kpa
0.45
11
39
11
40
2.96
2.46
2.2
3.5
—
—
—
0
0
8
22
3.86
2.42
2.5
3.2
123.87
134.45
g/l
—
8
22
36
230
1.88
2.25
7.9
5.6
—
—
—
0
0
18
90
2.22
2.17
1.5
1.7
1071.85
1052.86
nmol/l
0.03
13
68
24
135
2.02
2.15
3.1
3.1
—
—
—
0
0
54
404
1.72
1.92
5.0
2.6
—
—
—
0
0
31
198
1.82
1.90
15.6
5.5
1.20
1.10
inr
—
10
81
55
416
1.71
1.87
4.8
5.2
6.15
6.16
mmol/l
0.02
47
346
6
17
3.68
1.86
2.3
2.8
27.43
24.46
mmol/l
—
6
17
13
63
2.22
1.68
1.2
1.7
—
—
—
0
0
28
184
1.72
1.54
3.3
2.7
0.12
0.17
e6/l
0.31
18
133
6
21
2.97
1.53
4.3
4.8
4.12
3.37
e9/l
—
6
21
6
21
2.97
1.53
4.7
5.0
60.33
53.05
%
—
6
21
6
22
2.83
1.45
20.8
3.7
25.52
24.37
mmol/l
—
6
22
5
16
3.23
1.45
4.6
6.1
—
—
—
0
0
32
224
1.63
1.38
1.9
1.6
101.56
97.69
pmol/l
0.18
22
109
35
251
1.60
1.37
1.5
1.3
0.46
1.39
u/ml
—
8
69
8
34
2.47
1.32
1.9
2.4
4.50
5.04
kpa
—
8
34
8
35
2.39
1.30
16.1
9.5
—
—
—
0
0
29
203
1.60
1.24
3.2
2.7
30.99
105.65
e6/l
1.09
20
147
73
628
1.59
1.24
4.6
3.9
14.69
14.46
pmol/l
0.32
65
579
48
380
1.50
1.18
7.4
5.0
0.05
0.04
e9/l
0.35
42
342
0
33
0.00
1.18
0.0
1.2
—
—
—
0
0
27
188
1.60
1.18
3.3
2.7
—
—
—
0
0
24
163
1.62
1.16
10.0
7.5
—
—
—
0
0
8
40
2.08
1.15
1.6
2.2
1.21
1.24
mmol/l
—
8
33
70
603
1.52
1.12
5.4
3.8
36.90
36.79
mmol/mol
0.03
63
569
5
21
2.45
1.10
3.8
3.0
23.40
23.78
mmol/l
—
5
21
11
60
1.94
1.07
1.5
1.3
—
—
—
0
0
9
47
2.00
1.05
1.4
2.4
—
—
—
0
0
47
378
1.46
1.04
7.5
5.1
0.59
0.54
e9/l
0.95
42
342
9
48
1.96
1.04
3.3
5.6
—
—
—
0
0
50
409
1.44
1.00
7.2
5.0
1.66
1.98
e9/l
3.00
45
374
0
31
0.00
0.98
0.0
1.9
—
—
—
0
0
9
51
1.84
0.97
1.1
1.1
—
—
—
0
0
6
27
2.30
0.95
4.2
21.0
—
—
—
0
0
16
104
1.64
0.91
4.4
2.2
1000.30
1675.39
ng/l
—
10
47
23
167
1.49
0.83
1.8
2.2
292.04
189.43
u/l
0.35
23
161
13
82
1.67
0.83
1.6
1.2
—
—
—
0
0
11
66
1.75
0.82
1.3
1.2
—
—
—
0
0
43
355
1.37
0.77
10.7
7.4
0.00
0.00
e9/l
0.00
37
299
28
216
1.41
0.74
1.7
1.4
2.08
2.00
g/l
0.12
19
139
5
25
2.05
0.74
1.4
1.6
—
—
—
0
0
19
136
1.49
0.73
2.5
2.6
429.64
542.14
mosm/kgh2o
1.51
14
115
5
26
1.97
0.71
1.2
1.0
—
—
—
0
0
89
834
1.57
0.70
14.6
9.6
22.91
20.06
mg/l
0.27
69
626
26
201
1.40
0.68
3.3
2.5
9.07
21.59
ng/l
2.62
15
91
5
28
1.83
0.67
1.4
1.4
—
—
—
0
0
33
267
1.35
0.66
3.8
3.2
1030.47
65.13
e6/l
0.51
22
162
21
157
1.43
0.66
1.4
1.6
1.48
1.39
mmol/l
0.15
16
132
24
304
0.72
0.65
2.4
2.0
—
—
—
0
0
5
30
1.70
0.62
1.0
1.1
—
—
—
0
0
5
30
1.70
0.62
1.6
1.4
—
—
—
0
0
28
225
1.34
0.58
3.2
2.0
—
—
—
0
0
23
286
0.75
0.55
2.5
1.8
—
—
—
0
0
76
704
1.32
0.53
3.3
3.0
5.38
5.56
mmol/l
0.87
67
642
15
197
0.72
0.50
1.5
1.5
—
—
—
0
0
18
140
1.35
0.46
1.2
1.2
—
—
—
0
0
8
55
1.49
0.44
1.3
1.1
—
—
—
0
0
5
31
1.64
0.43
1.6
1.6
—
—
—
0
0
79
743
1.29
0.43
5.6
4.6
1.86
1.76
mu/l
0.43
73
699
11
79
1.44
0.43
1.1
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
3.8
—
—
—
0
0
18
144
1.30
0.38
3.4
2.4
242.04
95.61
ug/g
0.36
12
110
11
82
1.38
0.36
2.7
2.3
—
—
—
0
0
24
204
1.23
0.32
6.5
4.0
—
—
—
0
0
31
348
0.84
0.29
1.5
1.8
—
—
—
0
0
8
63
1.29
0.28
1.3
1.3
—
—
—
0
0
87
841
1.25
0.26
15.8
10.8
41.70
40.84
%
0.76
67
707
49
453
1.16
0.26
1.9
2.2
—
—
—
0
0
6
83
0.71
0.25
1.0
1.4
—
—
—
0
0
11
88
1.28
0.23
1.4
1.9
—
—
—
0
0
8
101
0.77
0.22
1.5
1.5
—
—
—
0
0
96
969
0.81
0.22
22.8
14.1
136.90
135.88
g/l
0.26
96
955
93
905
1.35
0.22
14.0
8.7
—
—
—
0
0
96
968
0.83
0.22
22.6
14.0
29.87
29.98
pg
0.21
96
955
0
11
0.00
0.21
0.0
3.7
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
17
147
1.19
0.19
2.5
2.3
—
—
—
0
0
7
59
1.20
0.18
2.4
2.3
—
20.48
—
0
5
10
82
1.24
0.18
1.5
1.4
—
—
—
0
0
35
377
0.89
0.17
1.8
1.9
—
—
—
0
0
8
67
1.21
0.17
1.5
1.4
—
—
—
0
0
8
99
0.79
0.14
1.5
1.4
—
—
—
0
0
8
99
0.79
0.14
1.5
1.4
—
—
—
0
0
35
373
0.91
0.14
1.6
1.8
—
—
—
0
0
11
126
0.86
0.12
1.5
1.5
—
—
—
0
0
62
601
1.08
0.10
4.5
4.0
—
—
—
0
0
96
967
0.85
0.10
22.6
14.0
89.22
89.41
fl
0.15
96
955
5
44
1.14
0.10
2.2
2.4
—
—
—
0
0
11
97
1.15
0.09
3.1
3.6
—
—
—
0
0
74
756
0.92
0.09
3.5
3.1
2.64
2.73
mmol/l
0.51
69
703
5
62
0.80
0.08
2.2
3.3
1.04
1.55
ug/l
—
5
51
42
436
0.94
0.08
3.5
3.1
0.00
0.00
estimate
0.00
11
98
79
776
1.08
0.07
17.5
11.9
333.94
334.27
g/l
0.12
79
771
10
111
0.89
0.06
1.5
1.8
—
—
—
0
0
20
188
1.08
0.06
3.3
3.1
8.03
8.10
mmol/l
0.02
14
162
11
100
1.11
0.05
1.5
1.8
—
—
—
0
0
42
432
0.95
0.05
3.3
2.9
0.00
0.00
estimate
0.00
11
103
24
229
1.06
0.05
2.6
3.1
0.00
0.00
estimate
0.00
11
106
25
239
1.06
0.04
2.7
2.5
—
—
—
0
0
26
271
0.95
0.04
2.9
2.6
—
—
—
0
0
34
349
0.96
0.02
3.2
2.7
—
—
—
0
0
42
429
0.96
0.02
4.9
4.3
0.00
0.00
estimate
0.00
11
106
17
178
0.95
0.02
3.5
3.0
—
—
—
0
0
11
112
0.98
0.00
1.5
1.8
—
—
—
0
0
19
194
0.97
0.00
1.6
1.6
—
—
—
0
0
11
111
0.99
0.00
1.5
1.8
—
—
—
0
0
11
111
0.99
0.00
1.5
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.8
—
3.95
—
0
8
0
8
0.00
0.00
0.0
2.8
—
105.88
—
0
8
0
8
0.00
0.00
0.0
2.8
—
—
—
0
0
7
72
0.97
0.00
1.9
2.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
160.68
—
0
9
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
30.86
—
0
7
0
5
0.00
0.00
0.0
1.8
—
148.60
—
0
5
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
3.98
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
2.11
—
0
5
0
6
0.00
0.00
0.0
2.3
—
16.07
—
0
6

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_PDA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have Q17_PDA.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: Q17_PDA – Isolated patent ductus arteriosus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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