mononeuropathy: Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ischemia; traumatic injury; compression; connective tissue diseases; cumulative trauma disorders; and other conditions.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
321 |
4. Check minimum number of eventsNone |
321 |
5. Include endpointsNone |
321 |
6. Filter based on genotype QC (FinnGen only) |
294 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G58
- Name in latin
- Neuropathia intercostalis
Similar endpoints
↥List of similar endpoints to
Intercostal neuropathy
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1814 | 986 | 815 |
| Only index persons | 1687 | 950 | 737 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 55.78 | 56.59 | 54.97 |
| Only index persons | 55.47 | 56.25 | 54.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 294 | 161 | 133 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 57.37 | 55.21 | 59.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 300
- Matched controls
- 3000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G58.0
ICD-10 Finland
Intercostal neuropathy
+∞
307.7
299
*
N03AX16
ATC
[U] pregabalin
10.6
96.7
177
360
N03AX12
ATC
[U] gabapentin; oral
10.9
96.5
149
248
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
7.9
63.0
113
212
N02AX02
ATC
tramadol; systemic, rectal
8.2
61.5
232
884
R52.2
ICD-10 Finland
Other chronic pain
13.8
54.0
54
47
G56.0
ICD-10 Finland
Carpal tunnel syndrome
13.8
52.1
52
45
N06AX21
ATC
duloxetine; oral
7.3
47.7
84
151
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
5.2
43.4
188
737
N06AA09
ATC
amitriptyline; systemic
7.0
42.2
76
139
M54.6
ICD-10 Finland
Pain in thoracic spine
7.0
36.8
64
112
N02BF02
ATC
pregabalin; oral
6.9
30.8
53
91
N02BF01
ATC
gabapentin; oral
5.3
25.9
60
136
N03AX09
ATC
lamotrigine; oral
7.8
25.7
38
55
R07.3
ICD-10 Finland
Other chest pain
4.7
23.8
63
159
N02AA05
ATC
oxycodone; systemic
3.6
22.5
100
366
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
24.5
22.2
31
14
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
4.1
21.6
71
211
N06AX16
ATC
venlafaxine; oral
4.1
21.3
69
203
R07.4
ICD-10 Finland
Chest pain, unspecified
3.2
21.2
133
599
N03AF02
ATC
oxcarbazepine; oral
8.2
20.3
28
37
A02BC05
ATC
esomeprazole; systemic
3.1
20.3
164
847
ACC51
NOMESCO Finland
Release of median nerve
213.5
19.8
20
*
A01
ICPC
Pain general/multiple sites
4.3
19.7
59
163
R52.9
ICD-10 Finland
Pain, unspecified
4.2
19.7
61
173
L05
ICPC
Flank/axilla symptom/complaint
4.7
19.0
48
116
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
3.2
18.9
101
409
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.3
18.8
95
372
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
15.7
18.5
30
21
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.7
18.3
47
115
M79.1
ICD-10 Finland
Myalgia
3.4
17.9
78
278
Z01.8
ICD-10 Finland
Other specified special examinations
3.1
17.8
98
402
M54.4
ICD-10 Finland
Lumbago with sciatica
3.4
17.7
80
292
M25.5
ICD-10 Finland
Pain in joint
2.9
17.6
136
672
G44.2
ICD-10 Finland
Tension-type headache
3.6
17.4
68
226
N03AF01
ATC
carbamazepine; oral, rectal
5.7
17.2
34
66
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.8
16.7
185
1093
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
16.5
121
578
M54.5
ICD-10 Finland
Low back pain
2.8
16.5
139
714
M54.8
ICD-10 Finland
Other dorsalgia
6.2
16.2
29
51
R51.80
ICD-10 Finland
Headache
3.2
15.6
74
276
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.8
15.6
108
498
M03BX02
ATC
tizanidine; oral
2.9
15.5
214
1394
N06AX11
ATC
mirtazapine; oral
2.7
15.4
131
671
N05AH04
ATC
quetiapine; oral
3.2
15.1
72
269
A02BC01
ATC
omeprazole; systemic
2.7
14.7
109
518
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
84.3
14.7
16
*
J45.9
ICD-10 Finland
Asthma, unspecified
3.0
14.7
81
329
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
14.5
160
923
A06AD11
ATC
lactulose; oral
3.2
14.4
68
252
M48.0
ICD-10 Finland
Spinal stenosis
3.5
14.4
56
184
N03AE01
ATC
clonazepam; systemic
5.1
14.4
32
69
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.5
14.2
162
946
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
5.3
14.1
30
62
R53
ICD-10 Finland
Malaise and fatigue
2.7
14.1
110
535
A02BC02
ATC
pantoprazole; systemic
3.0
14.1
237
1668
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
4.8
13.7
33
76
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.8
13.7
33
76
Z50.1
ICD-10 Finland
Other physical therapy
4.9
13.7
32
72
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.9
13.5
76
311
M03BC01
ATC
orphenadrine (citrate); systemic
2.8
13.5
91
410
M54.3
ICD-10 Finland
Sciatica
4.8
13.4
32
73
R52.0
ICD-10 Finland
Acute pain
6.1
13.4
24
42
M79.6
ICD-10 Finland
Pain in limb
2.5
13.3
162
965
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.7
13.1
45
136
J01MA12
ATC
levofloxacin; systemic
2.8
12.9
82
357
A02BC03
ATC
lansoprazole; oral
2.5
12.9
113
577
K30
ICD-10 Finland
Functional dyspepsia
3.3
12.8
54
186
A11
ICPC
Chest pain NOS
3.6
12.7
47
149
L28
ICPC
Limited function/disability (L)
2.7
12.2
82
367
K59.09
ICD-10 Finland
Constipation, unspecified
4.0
12.1
36
98
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
12.0
132
742
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.7
12.0
82
369
R06.0
ICD-10 Finland
Dyspnoea
2.5
11.8
107
551
N06AA10
ATC
nortriptyline; systemic
10.7
11.7
22
22
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.7
11.7
40
120
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.4
11.7
107
554
J01MA14
ATC
moxifloxacin; systemic
3.4
11.6
45
147
TAC00
NOMESCO Finland
Peripheral nerve block
+∞
11.5
11
*
UJF32
NOMESCO Finland
Coloscopy
2.5
11.5
99
497
AA1AD
NOMESCO Finland
CT of head and brain
2.4
11.4
111
589
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
11.3
101
515
M01AB55
ATC
diclofenac, combinations; oral
4.1
11.3
32
84
N05CF01
ATC
zopiclone; oral
2.3
11.1
119
658
D07AD01
ATC
clobetasol; topical
2.8
11.0
67
283
JN3AD
NOMESCO Finland
Abdominal CT examination
2.9
11.0
57
221
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
5.4
11.0
22
43
L04
ICPC
Chest symptom/complaint
4.0
10.9
33
91
TAC99
NOMESCO Finland
Other blockade for chronic pain
29.2
10.8
14
5
G50.0
ICD-10 Finland
Trigeminal neuralgia
29.2
10.8
14
5
L03
ICPC
Low back symptom/complaint
2.4
10.7
102
534
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
10.7
68
294
J01FF01
ATC
clindamycin; systemic
2.4
10.6
99
513
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.0
10.6
32
88
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.2
10.5
47
167
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.9
10.5
55
214
N06AB04
ATC
citalopram; systemic
2.6
10.5
77
357
L02
ICPC
Back symptom/complaint
3.0
10.4
51
191
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.1
10.4
49
180
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
4.5
10.3
26
62
M01AB05
ATC
diclofenac; systemic, rectal
2.3
10.1
215
1556
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
4.8
10.0
23
51
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
11.2
9.9
18
17
R29
ICPC
Respiratory symptom/complaint other
3.6
9.8
34
103
G58.9
ICD-10 Finland
Mononeuropathy, unspecified
56.9
9.7
11
*
M01AH01
ATC
celecoxib; oral
2.6
9.7
67
301
R20.2
ICD-10 Finland
Paraesthesia of skin
3.6
9.6
33
99
R42
ICD-10 Finland
Dizziness and giddiness
2.4
9.6
88
450
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.1
9.6
43
153
R02
ICPC
Shortness of breath/dyspnoea
2.7
9.5
57
238
WX110
NOMESCO Finland
Infiltration anesthesia
2.4
9.4
226
1693
M54
ICD-10 Finland
Dorsalgia
2.8
9.4
51
202
M01AH03
ATC
valdecoxib; oral
4.0
9.4
28
76
H02AB06
ATC
prednisolone; systemic
2.1
9.4
158
1030
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
9.3
139
864
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.0
9.3
27
72
L17
ICPC
Foot/toe symptom/complaint
2.2
9.2
108
610
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.1
9.2
41
145
P01AB01
ATC
metronidazole; oral, rectal
2.1
9.2
140
876
M01AH05
ATC
etoricoxib; oral
2.2
9.2
202
1454
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
9.1
85
437
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
9.1
100
551
L13
ICPC
Hip symptom/complaint
2.4
9.1
78
387
A06AC01
ATC
ispaghula (psylla seeds); oral
2.2
9.0
98
536
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.8
9.0
29
83
R52.1
ICD-10 Finland
Chronic intractable pain
19.3
9.0
13
7
J02AC01
ATC
fluconazole; systemic
2.1
9.0
127
771
G56.2
ICD-10 Finland
Lesion of ulnar nerve
24.9
9.0
12
5
R60.0
ICD-10 Finland
Localized oedema
2.7
8.9
53
220
ZXE00
NOMESCO Finland
One hour or less
2.1
8.9
129
791
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
2.1
8.9
177
1221
G47.3
ICD-10 Finland
Sleep apnoea
2.3
8.8
89
472
L01
ICPC
Neck symptom/complaint
2.5
8.7
63
289
A02BA04
ATC
nizatidine; systemic
3.4
8.6
32
101
M01AH02
ATC
rofecoxib; oral
2.7
8.6
50
205
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
3.0
8.6
41
151
N05BA01
ATC
diazepam; systemic, rectal
2.6
8.6
54
231
A02BA02
ATC
ranitidine; systemic
2.4
8.6
73
360
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
28.4
8.5
11
*
N05BA04
ATC
oxazepam; oral
2.2
8.5
94
516
S22.3
ICD-10 Finland
Fracture of rib
3.1
8.5
37
129
SPAT1229
SPAT
Assessment of need for aid
3.4
8.4
32
103
G58.8
ICD-10 Finland
Other specified mononeuropathies
+∞
8.4
8
*
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
6.8
8.3
20
31
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.0
8.2
169
1165
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.2
8.2
84
446
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.9
8.2
40
149
N17
ICPC
Vertigo/dizziness
2.6
8.2
52
223
M01AX17
ATC
nimesulide; oral
2.2
8.2
84
447
N05BA12
ATC
alprazolam; oral
3.0
8.1
39
144
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
4.1
8.1
23
60
N05CF02
ATC
zolpidem; oral
2.4
8.1
63
297
Z71.8
ICD-10 Finland
Other specified counselling
2.1
8.1
119
726
N06AX26
ATC
vortioxetine; oral
3.3
8.1
32
105
C01DA14
ATC
isosorbide mononitrate; oral
2.5
8.1
57
257
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
8.0
63
299
R03AC02
ATC
salbutamol; inhalant
2.0
8.0
177
1250
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.0
8.0
23
61
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.5
7.9
54
240
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.3
7.8
69
344
M47.9
ICD-10 Finland
Spondylosis, unspecified
7.8
7.8
17
23
D06
ICPC
Abdominal pain localized other
3.0
7.8
37
136
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
7.7
95
541
M70.6
ICD-10 Finland
Trochanteric bursitis
2.5
7.6
53
237
Z02.7
ICD-10 Finland
Issue of medical certificate
3.1
7.6
33
115
M02AA10
ATC
ketoprofen; topical
2.5
7.6
55
251
D01
ICPC
Abdominal pain/cramps general
2.6
7.5
48
206
R96
ICPC
Asthma
2.8
7.5
40
157
B02
ICD-10 Finland
Zoster [herpes zoster]
3.6
7.4
25
74
ZXA00
NOMESCO Finland
Right side
2.1
7.4
89
502
SPAT1153
SPAT
Removal of sutures
2.0
7.4
102
606
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.6
7.3
44
183
TAC02
NOMESCO Finland
Block of intercostal nerve
+∞
7.3
7
*
J01DB01
ATC
cefalexin; oral
2.4
7.2
254
2087
WX250
NOMESCO Finland
Intercostal blockade
30.8
7.2
9
*
J01MA02
ATC
ciprofloxacin; systemic
1.9
7.1
129
840
P76
ICPC
Depressive disorder
3.4
7.0
26
82
KH1AD
NOMESCO Finland
CT of urinary organs
4.2
7.0
19
48
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.9
7.0
142
959
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.9
7.0
33
121
G04CA02
ATC
tamsulosin; oral
2.1
6.9
82
458
N02BE01
ATC
paracetamol; systemic, rectal
3.2
6.9
278
2397
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
6.9
56
268
L12
ICPC
Hand/finger symptom/complaint
2.3
6.9
60
296
N01
ICPC
Headache
2.6
6.9
43
182
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.0
6.9
20
53
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.7
6.9
38
151
M03BC51
ATC
orphenadrine, combinations; systemic
2.0
6.8
94
555
C07AB07
ATC
bisoprolol; oral
1.9
6.8
160
1131
J01DA01
ATC
[U] cefalexin
1.9
6.8
189
1410
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.6
6.7
42
178
SPAT1254
SPAT
Administration of medicine
2.4
6.7
51
237
J20
ICD-10 Finland
Acute bronchitis
2.6
6.7
41
172
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.8
6.7
21
59
G53.0
ICD-10 Finland
Postzoster neuralgia
23.1
6.7
9
*
WZC00
NOMESCO Finland
Treatment plan or consultation
1.9
6.7
119
767
R03BB04
ATC
tiotropium bromide; inhalant
2.7
6.7
38
154
H01
ICPC
Ear pain/earache
2.6
6.6
41
173
ZXD05
NOMESCO Finland
Urgent procedure
2.0
6.6
96
576
N06AB06
ATC
sertraline; oral
2.6
6.6
39
161
R4110
NOMESCO Finland
Physiotherapy
2.0
6.6
95
569
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
6.6
53
253
C08CA01
ATC
amlodipine; oral
1.9
6.6
130
866
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.6
6.5
40
168
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
6.5
84
483
X59
ICD-10 Finland
Exposure to unspecified factor
2.2
6.5
63
325
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
7.7
6.5
14
19
GAC46
NOMESCO Finland
Partial decortication of pleura
71.3
6.4
7
*
G43.9
ICD-10 Finland
Migraine, unspecified
3.3
6.4
24
76
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
4.2
6.4
17
42
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.0
6.4
92
549
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.9
6.4
31
115
N05CD07
ATC
temazepam; oral
2.5
6.3
43
190
M75.9
ICD-10 Finland
Shoulder lesion, unspecified
3.4
6.3
23
72
N02AC04
ATC
dextropropoxyphene; oral
3.7
6.3
20
57
G51.0
ICD-10 Finland
Bell palsy
+∞
6.3
6
*
GAE06
NOMESCO Finland
Excision of lesion of chest wall
+∞
6.3
6
*
WX723
NOMESCO Finland
CPAP therapy
3.6
6.3
21
62
A03FA02
ATC
cisapride; oral, rectal
3.0
6.3
29
105
Z72.0
ICD-10 Finland
Tobacco use
6.0
6.2
16
28
R60.9
ICD-10 Finland
Oedema, unspecified
3.2
6.2
25
83
R07.2
ICD-10 Finland
Precordial pain
7.9
6.2
13
17
R04.2
ICD-10 Finland
Haemoptysis
4.3
6.2
16
39
WX290
NOMESCO Finland
Other blockage of nerve
1.8
6.2
143
996
M54.1
ICD-10 Finland
Radiculopathy
3.8
6.1
19
53
-1, ,
NOMESCO Finland
1.9
6.1
106
673
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.0
6.1
28
101
K02.1
ICD-10 Finland
Caries of dentine
1.8
6.1
177
1319
R50.9
ICD-10 Finland
Fever, unspecified
2.2
6.1
54
269
N06AX12
ATC
bupropion; oral
3.1
6.1
26
90
J01FA06
ATC
roxithromycin; oral
1.8
6.1
128
865
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
6.0
116
761
M01AC06
ATC
meloxicam; systemic, rectal
1.9
6.0
117
770
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.8
6.0
18
49
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.4
6.0
42
188
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
152
831
2.68
15.72
3.5
2.6
63.77
67.48
u/l
0.10
144
772
228
1575
2.87
13.98
6.4
5.3
6.57
6.62
mmol/l
0.14
221
1500
240
1725
2.96
13.23
5.9
4.7
31.25
506.04
e6/l
—
8
27
209
1407
2.60
13.06
7.3
7.2
11.15
11.92
umol/l
0.29
203
1343
195
1281
2.49
12.69
19.3
12.8
1.20
1.26
inr
0.95
176
1051
215
1501
2.53
11.87
9.5
9.8
4.45
4.16
e9/l
0.77
192
1310
180
1167
2.36
11.68
4.7
5.1
35.95
35.73
g/l
0.20
171
1100
116
628
2.38
11.39
3.3
2.5
3.99
6.36
e6/l
0.96
109
579
113
617
2.33
10.77
1.8
1.7
0.98
1.49
mg/l
2.00
90
484
153
958
2.22
10.38
4.0
3.2
—
—
—
0
0
255
1995
2.85
10.08
11.0
8.4
77.93
78.29
u/l
0.06
246
1883
131
782
2.20
9.89
3.9
3.2
0.10
0.53
e6/l
3.80
104
573
91
469
2.35
9.77
3.8
3.5
0.80
0.82
mmol/l
1.00
85
445
200
1419
2.23
9.63
4.6
3.8
0.00
0.00
estimate
-0.00
61
291
201
1429
2.23
9.63
4.6
3.8
0.00
5.40
estimate
0.50
62
301
247
1918
2.63
9.62
6.2
4.1
12.54
11.82
mm/h
0.31
237
1773
192
1348
2.18
9.39
8.0
7.6
1.21
1.21
mmol/l
0.25
161
1158
201
1448
2.18
9.05
4.6
3.9
0.00
0.00
estimate
-0.00
54
273
147
949
2.08
8.77
2.8
3.4
2.35
2.36
mmol/l
0.21
137
858
80
411
2.29
8.52
1.3
1.3
6.32
10.04
u/ml
0.33
26
162
130
809
2.07
8.50
2.8
2.2
161.56
196.10
u/l
0.44
125
768
88
471
2.23
8.50
2.3
2.0
—
—
—
0
0
158
1058
2.04
8.42
4.5
3.8
0.00
0.03
estimate
0.96
52
235
77
398
2.26
8.04
2.7
2.3
2.32
2.30
g/l
0.08
72
365
83
446
2.19
7.87
1.4
1.3
25.74
27.41
iu/ml
0.04
19
137
154
1044
1.98
7.71
6.7
3.7
24.30
89.67
ng/l
0.64
121
744
94
535
2.10
7.67
5.6
3.9
232.89
302.49
ng/l
0.13
71
435
78
417
2.18
7.45
2.9
2.4
11.35
13.39
umol/l
1.89
72
389
66
334
2.25
7.19
2.4
1.9
—
—
—
0
0
170
1211
1.93
7.16
7.5
6.8
1.21
1.21
mmol/l
0.29
158
1113
136
900
1.93
7.15
3.6
3.2
28.58
33.80
u/l
1.31
128
852
110
678
1.98
7.12
2.6
2.9
337.62
349.09
umol/l
0.47
97
603
56
270
2.32
6.82
5.6
3.4
—
—
—
0
0
166
1192
1.88
6.64
2.6
2.4
76.27
78.28
nmol/l
0.39
156
1054
69
370
2.12
6.46
2.9
2.3
21.74
22.93
%
0.26
64
348
67
356
2.14
6.42
2.3
1.8
—
—
—
0
0
120
790
1.86
6.20
4.8
3.9
0.00
0.01
estimate
0.50
57
280
54
270
2.22
6.00
2.7
2.6
27.80
30.10
u/l
0.35
45
230
125
846
1.82
5.83
3.7
3.3
1398.28
1223.18
ng/l
0.22
103
709
94
583
1.89
5.78
1.4
1.3
2.92
1.36
u/ml
0.36
27
169
45
213
2.31
5.69
2.7
2.9
66.61
66.95
g/l
0.12
39
196
103
665
1.84
5.55
2.8
2.1
2.70
2.90
mg/l
0.50
98
564
34
144
2.54
5.46
3.1
3.5
2.48
2.10
mmol/l
0.30
25
108
93
584
1.86
5.46
4.1
4.0
1.02
1.02
kg/l
0.34
71
392
15
31
5.04
5.19
1.5
1.5
—
—
—
0
0
21
71
3.11
5.09
1.4
1.3
—
—
—
0
0
24
88
2.88
5.07
1.4
1.6
18.28
6.87
u/ml
—
5
19
75
450
1.89
5.03
3.1
3.2
4.09
2.14
e6/l
0.33
40
214
16
46
3.62
4.96
2.0
2.0
—
—
—
0
0
41
199
2.23
4.88
4.0
3.2
96.17
227.97
ng/l
3.92
36
185
114
783
1.74
4.86
4.5
3.3
0.00
0.00
estimate
0.50
54
224
159
1197
1.70
4.84
3.1
2.9
—
—
estimate
—
0
0
84
535
1.79
4.62
1.8
1.7
422.09
26651918.84
pmol/l
0.50
67
439
33
151
2.33
4.50
1.1
1.2
513.94
162.66
u/ml
0.41
33
138
9
12
7.69
4.38
2.2
4.7
—
—
—
0
0
42
215
2.11
4.38
4.6
3.9
1.23
1.22
mmol/l
0.21
37
186
154
1176
1.64
4.24
2.4
2.1
93.49
96.48
pmol/l
0.30
80
609
10
17
6.04
4.16
1.4
1.5
—
—
—
0
0
21
80
2.75
4.16
2.0
1.8
—
—
—
0
0
232
1978
1.76
4.09
4.8
4.1
14.54
14.80
pmol/l
0.82
212
1796
279
2530
2.47
4.08
29.6
16.0
21.85
24.64
mg/l
0.86
255
2089
20
75
2.79
4.08
1.3
1.3
—
1.81
—
0
11
29
131
2.34
4.08
1.1
1.0
—
—
—
0
0
76
488
1.75
4.01
3.3
3.0
0.88
1.08
e6/l
0.21
41
254
22
88
2.62
3.98
4.3
2.8
—
—
—
0
0
13
32
4.20
3.95
1.8
1.5
—
—
—
0
0
69
433
1.77
3.94
1.9
1.6
1272.15
1241.53
nmol/l
0.09
55
322
20
77
2.71
3.89
1.4
1.3
—
1.60
—
0
5
9
15
6.15
3.84
1.8
1.5
—
—
—
0
0
37
190
2.08
3.83
2.3
1.5
—
—
—
0
0
18
66
2.84
3.83
1.6
1.5
—
—
—
0
0
17
61
2.89
3.75
1.2
1.3
—
1.03
—
0
6
8
12
6.81
3.69
1.8
1.5
—
—
—
0
0
8
12
6.81
3.69
1.8
1.4
—
—
—
0
0
17
62
2.85
3.65
2.1
1.5
—
—
—
0
0
40
216
1.98
3.62
2.4
2.6
3.57
6.03
ug/l
1.43
35
191
208
1747
1.62
3.61
4.5
3.3
57.74
49.29
u/l
0.54
193
1638
52
307
1.84
3.61
6.3
10.1
1.39
0.82
mmol/l
0.60
44
260
16
57
2.91
3.58
1.4
1.4
—
—
—
0
0
16
57
2.91
3.58
1.4
1.4
—
—
—
0
0
8
13
6.29
3.52
1.1
1.2
—
—
—
0
0
8
14
5.84
3.36
1.1
1.1
—
—
—
0
0
153
1214
1.53
3.28
3.8
2.9
99.35
130.39
ug/l
1.64
146
1120
10
24
4.27
3.22
2.0
1.9
—
—
—
0
0
23
106
2.27
3.12
2.3
1.7
7.25
3.10
iu/ml
—
6
21
51
313
1.76
3.12
6.4
10.0
5.31
5.03
kpa
1.97
51
302
51
313
1.76
3.12
6.4
10.0
11.45
12.11
kpa
0.59
51
304
44
260
1.81
3.05
6.6
11.2
124.84
120.96
g/l
0.67
44
254
19
82
2.41
2.98
5.2
3.0
0.30
1.53
g/l
1.19
13
72
19
82
2.41
2.98
1.5
1.1
—
—
—
0
0
14
53
2.72
2.83
1.1
1.4
354.14
2394.95
e6/l
—
7
40
63
422
1.62
2.78
1.6
1.5
—
—
—
0
0
18
79
2.36
2.73
2.3
1.7
—
—
—
0
0
60
401
1.62
2.67
5.7
7.4
104.52
104.14
mmol/l
0.24
60
401
35
201
1.84
2.66
4.3
3.2
61.89
61.42
ml/min/173m2
0.02
18
90
78
556
1.54
2.64
2.6
2.8
2.44
2.45
mmol/l
0.73
72
501
10
30
3.41
2.62
1.3
1.1
—
—
—
0
0
7
15
4.75
2.61
1.1
1.1
—
—
—
0
0
14
56
2.57
2.57
1.8
1.5
—
—
—
0
0
26
137
1.98
2.55
2.7
3.3
1.02
1.02
ratio
0.67
26
128
28
152
1.93
2.53
9.1
10.3
25.77
24.24
mmol/l
1.71
28
145
115
897
1.46
2.50
4.3
3.9
9.52
7.22
mg/mmol
0.32
76
551
16
70
2.36
2.46
1.4
1.7
291.69
308.92
mu/l
0.06
16
70
260
2384
1.68
2.43
6.3
5.0
1.91
1.95
mu/l
0.19
239
2188
15
64
2.41
2.43
1.8
1.8
2904.13
6042.74
u/l
—
8
18
21
104
2.10
2.43
1.7
1.4
0.44
0.33
mg/l
0.30
14
47
18
84
2.22
2.40
1.4
1.5
—
—
—
0
0
13
52
2.57
2.39
1.1
1.3
4.40
3.92
e6/l
—
5
37
12
47
2.62
2.30
1.9
1.6
—
—
—
0
0
16
73
2.26
2.25
1.1
1.2
—
—
—
0
0
16
73
2.26
2.25
7.6
3.6
2.73
2.31
index
0.12
11
49
11
41
2.75
2.23
1.1
1.3
1.20
3.08
u/ml
—
5
12
18
87
2.14
2.22
3.9
2.5
10.97
10.67
g/l
0.12
13
77
15
67
2.30
2.21
1.9
1.5
—
—
—
0
0
16
74
2.23
2.19
1.1
1.2
—
—
—
0
0
7
19
3.75
2.16
1.6
1.2
—
—
—
0
0
17
82
2.14
2.11
4.3
3.6
1.19
3.60
ratio
—
8
47
8
25
3.26
2.11
1.5
1.2
—
—
—
0
0
267
2485
1.68
2.10
26.2
15.7
81.35
79.71
ml/min/173m2
0.65
259
2303
5
10
5.06
2.08
1.2
1.0
—
—
—
0
0
5
10
5.06
2.08
1.4
1.1
—
—
—
0
0
7
20
3.56
2.06
1.6
1.2
—
—
—
0
0
7
20
3.56
2.06
1.6
1.2
—
—
—
0
0
7
20
3.56
2.06
1.6
1.2
—
—
—
0
0
6
15
4.06
2.05
2.3
1.4
—
—
—
0
0
6
15
4.06
2.05
2.3
1.4
—
—
—
0
0
13
57
2.34
2.00
1.8
1.5
—
—
—
0
0
99
781
1.40
1.95
1.8
1.7
19.36
20.75
nmol/l
0.40
86
652
24
137
1.82
1.90
1.5
1.4
—
—
—
0
0
7
22
3.23
1.89
1.6
1.2
—
—
—
0
0
14
66
2.18
1.85
1.4
1.2
—
—
—
0
0
9
36
2.55
1.75
1.0
1.3
—
—
—
0
0
7
24
2.96
1.73
1.1
1.0
—
—
—
0
0
7
24
2.96
1.73
1.0
1.1
—
—
—
0
0
5
13
3.89
1.72
2.6
1.4
—
—
—
0
0
5
13
3.89
1.72
2.6
1.4
—
—
—
0
0
42
289
1.53
1.67
2.4
1.7
1.51
1.47
%
0.19
37
253
7
25
2.84
1.66
5.4
2.7
0.86
0.80
index
—
7
25
82
643
1.38
1.65
3.1
2.4
—
—
—
0
0
42
292
1.51
1.60
2.7
4.6
2.93
45.91
ug/l
0.94
33
242
12
57
2.15
1.57
1.8
2.3
8.03
7.06
pmol/l
0.17
12
57
264
2488
1.51
1.52
5.6
5.0
6.08
5.98
mmol/l
0.61
240
2273
35
237
1.54
1.50
3.6
2.8
4.68
4.31
kpa
0.61
35
231
281
2694
1.68
1.39
17.0
12.1
28.93
25.99
u/l
0.39
276
2613
174
1550
1.29
1.38
3.5
2.9
—
—
—
0
0
44
324
1.42
1.27
2.9
3.3
9.22
7.96
umol/l
0.10
38
293
5
19
2.66
1.22
1.0
1.1
—
—
—
0
0
281
2706
1.61
1.19
35.3
20.9
75.90
78.44
umol/l
0.72
281
2677
257
2437
1.38
1.16
7.3
6.2
39.78
39.31
mmol/mol
0.35
240
2275
5
20
2.52
1.15
1.0
1.1
—
—
—
0
0
5
21
2.40
1.09
1.6
1.1
—
—
—
0
0
20
129
1.59
1.08
1.5
2.0
—
—
—
0
0
33
238
1.43
1.08
5.6
6.9
8.60
9.73
mmol/l
0.50
33
228
25
171
1.50
1.06
1.2
1.2
50.35
128.74
u/ml
—
6
76
7
33
2.15
1.06
2.9
1.5
—
—
—
0
0
7
33
2.15
1.06
2.9
1.5
—
—
—
0
0
5
23
2.19
0.98
1.0
1.4
—
—
—
0
0
25
175
1.47
0.96
2.2
1.7
—
—
—
0
0
10
55
1.85
0.93
1.2
1.2
96.18
19.43
u/l
—
10
46
6
28
2.17
0.92
1.2
1.4
0.15
0.19
nmol/l
—
6
19
6
30
2.02
0.87
3.0
2.3
—
—
—
0
0
28
205
1.40
0.87
1.6
1.4
—
—
—
0
0
8
47
1.72
0.81
1.3
1.2
0.99
0.85
nmol/l
—
8
36
261
2511
1.30
0.79
5.3
5.0
1.34
1.46
mmol/l
5.77
239
2321
6
33
1.83
0.79
3.2
1.5
—
—
—
0
0
6
33
1.83
0.79
3.2
1.5
—
—
—
0
0
6
33
1.83
0.79
3.2
1.5
—
—
—
0
0
6
34
1.78
0.76
3.2
1.4
—
—
—
0
0
18
125
1.47
0.74
1.2
1.4
—
—
—
0
0
20
143
1.43
0.72
1.5
2.5
0.63
0.61
%
0.10
20
143
250
2401
1.25
0.71
4.6
4.2
1.57
1.28
mmol/l
4.03
230
2206
12
77
1.58
0.69
2.2
1.3
—
—
—
0
0
5
27
1.87
0.68
2.8
2.3
—
—
—
0
0
13
86
1.53
0.67
1.2
1.2
—
—
—
0
0
20
269
0.73
0.67
2.3
2.1
3.52
3.60
ratio
0.07
13
226
33
262
1.29
0.64
1.8
2.0
—
—
—
0
0
5
29
1.74
0.64
3.4
2.4
—
—
—
0
0
15
106
1.44
0.59
1.4
2.0
—
—
—
0
0
122
1117
1.16
0.57
1.9
1.9
1.70
1.32
mmol/l
2.20
98
934
5
89
0.55
0.57
1.2
1.2
1.14
0.90
g/l
—
5
89
30
240
1.28
0.56
1.8
1.9
—
—
—
0
0
260
2524
1.23
0.54
5.5
5.1
4.37
4.61
mmol/l
3.35
238
2341
20
153
1.33
0.52
4.5
12.6
17.04
15.64
%
1.66
20
148
33
272
1.24
0.50
9.6
6.6
—
—
—
0
0
282
2767
1.32
0.49
41.2
24.0
91.34
91.34
fl
0.01
282
2740
282
2767
1.32
0.49
41.4
24.1
251.18
245.47
e9/l
0.80
282
2717
282
2768
1.31
0.48
41.6
24.6
40.25
40.47
%
0.34
282
2738
282
2769
1.31
0.46
41.7
24.2
134.22
135.48
g/l
0.75
282
2740
19
147
1.31
0.46
1.6
2.5
1.02
1.20
%
0.55
19
147
5
84
0.59
0.46
1.2
1.1
1.43
1.54
g/l
—
5
84
6
92
0.65
0.43
1.5
1.6
871.60
893.85
mu/l
—
6
74
28
336
0.82
0.43
4.7
4.6
27.44
31.12
%
0.95
16
211
8
57
1.41
0.42
1.9
1.4
—
—
—
0
0
5
32
1.57
0.42
2.6
3.0
1.19
1.20
mmol/l
—
5
32
5
32
1.57
0.42
1.2
2.3
—
—
—
0
0
10
70
1.44
0.42
1.2
1.2
—
—
—
0
0
14
105
1.35
0.42
2.1
2.2
—
—
—
0
0
5
33
1.52
0.41
2.6
2.9
103.80
105.39
mmol/l
—
5
33
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
9.63
—
0
16
15
193
0.77
0.40
2.5
1.9
3.42
3.62
mmol/l
—
9
151
5
34
1.48
0.40
1.2
1.3
—
—
—
0
0
10
71
1.42
0.39
1.2
1.1
—
12.84
—
0
8
263
2576
1.17
0.36
6.3
5.8
2.54
2.71
mmol/l
2.06
244
2386
6
42
1.44
0.35
1.0
1.0
—
—
—
0
0
6
43
1.40
0.35
1.0
1.2
—
—
—
0
0
12
97
1.25
0.23
1.7
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
15
128
1.18
0.18
5.2
7.3
1.70
1.40
%
0.71
15
121
7
62
1.13
0.17
1.1
1.3
—
—
—
0
0
94
900
1.06
0.17
5.1
5.5
1.37
2.53
ug/l
2.06
85
805
6
79
0.75
0.15
2.7
1.8
—
—
—
0
0
56
533
1.06
0.12
3.1
3.3
0.56
0.75
ug/l
1.95
38
355
74
723
1.03
0.05
4.4
4.5
22.78
21.32
%
0.23
30
355
38
369
1.03
0.03
1.7
1.5
—
—
—
0
0
7
72
0.97
-0.00
1.4
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.9
—
4.71
—
0
7
0
7
0.00
-0.00
0.0
2.3
—
39.71
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
82
0.97
-0.00
1.4
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.9
—
10.61
—
0
7
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
0.30
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_ICNEUROP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ICNEUROP | 1.431 [1.19, 1.73] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 163 out of 876 females with G6_ICNEUROP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ICNEUROP | 1.58 [1.33, 1.88] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 185 out of 723 males with G6_ICNEUROP died.
Mortality risk
Mortality risk for people of age
years, who have G6_ICNEUROP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.147% | 0.338% |
| 5 | 0.74% | 1.76% |
| 10 | 1.955% | 4.785% |
| 15 | 3.823% | 9.4% |
| 20 | 6.455% | 15.462% |
Relationships between endpoints
↥Index endpoint: G6_ICNEUROP – Intercostal neuropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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