mononeuropathy: Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ischemia; traumatic injury; compression; connective tissue diseases; cumulative trauma disorders; and other conditions.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
286 |
4. Check minimum number of eventsNone |
286 |
5. Include endpointsNone |
286 |
6. Filter based on genotype QC (FinnGen only) |
281 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G58
- Name in latin
- Neuropathia intercostalis
Similar endpoints
↥List of similar endpoints to
Intercostal neuropathy
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: unknown.
No upset table: unknown.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1814 | 986 | 815 |
| Only index persons | 1687 | 950 | 737 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 55.78 | 56.59 | 54.97 |
| Only index persons | 55.47 | 56.25 | 54.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 281 | 155 | 126 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | 57.19 | 55.19 | 59.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 286
- Matched controls
- 2860
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G58.0
ICD-10 Finland
Intercostal neuropathy
+∞
307.7
285
*
N03AX12
ATC
[U] gabapentin; oral
11.5
96.7
146
238
N03AX16
ATC
[U] pregabalin
10.8
94.3
172
350
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
8.9
66.7
108
183
N02AX02
ATC
tramadol; systemic, rectal
8.3
60.5
220
818
R52.2
ICD-10 Finland
Other chronic pain
16.1
56.9
52
39
G56.0
ICD-10 Finland
Carpal tunnel syndrome
15.9
51.4
47
35
N06AX21
ATC
duloxetine; oral
7.6
46.5
79
137
N06AA09
ATC
amitriptyline; systemic
7.6
45.2
76
130
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
5.0
39.9
173
674
M54.6
ICD-10 Finland
Pain in thoracic spine
6.3
28.5
54
102
N02BF02
ATC
pregabalin; oral
7.1
28.0
46
75
N03AX09
ATC
lamotrigine; oral
8.6
26.5
36
47
N02BF01
ATC
gabapentin; oral
6.3
25.0
46
84
R07.4
ICD-10 Finland
Chest pain, unspecified
3.4
21.9
124
530
N06AX16
ATC
venlafaxine; oral
4.4
21.7
65
181
R07.3
ICD-10 Finland
Other chest pain
4.7
21.4
56
140
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
24.7
20.8
29
13
M54.4
ICD-10 Finland
Lumbago with sciatica
3.8
20.4
78
258
A01
ICPC
Pain general/multiple sites
4.8
20.3
51
123
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
4.1
20.2
66
195
N02AA05
ATC
oxycodone; systemic
3.5
19.8
88
321
N03AF02
ATC
oxcarbazepine; oral
8.2
19.4
27
36
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.0
19.2
45
102
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
3.3
18.9
94
366
A02BC05
ATC
esomeprazole; systemic
3.0
18.8
154
798
R52.9
ICD-10 Finland
Pain, unspecified
4.3
18.6
54
146
ACC51
NOMESCO Finland
Release of median nerve
191.4
17.7
18
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.3
17.4
86
332
Z01.8
ICD-10 Finland
Other specified special examinations
3.1
16.7
91
371
M54.5
ICD-10 Finland
Low back pain
2.9
16.7
130
646
N06AX11
ATC
mirtazapine; oral
2.9
16.4
125
612
J45.9
ICD-10 Finland
Asthma, unspecified
3.3
16.2
78
295
N03AF01
ATC
carbamazepine; oral, rectal
5.7
16.2
32
62
M03BX02
ATC
tizanidine; oral
3.0
16.1
205
1306
M79.1
ICD-10 Finland
Myalgia
3.4
16.0
68
238
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
15.9
114
539
M25.5
ICD-10 Finland
Pain in joint
2.8
15.7
122
601
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
15.6
166
958
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
14.2
15.5
26
20
R51.80
ICD-10 Finland
Headache
3.3
15.5
70
254
A02BC01
ATC
omeprazole; systemic
2.8
15.2
107
499
L05
ICPC
Flank/axilla symptom/complaint
4.5
14.8
39
97
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
84.6
14.7
16
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.8
14.7
98
443
M54.3
ICD-10 Finland
Sciatica
5.2
14.6
32
68
N03AE01
ATC
clonazepam; systemic
5.2
14.4
31
65
A06AD11
ATC
lactulose; oral
3.3
14.3
65
236
A02BC02
ATC
pantoprazole; systemic
3.0
14.1
222
1530
M79.6
ICD-10 Finland
Pain in limb
2.6
14.0
147
830
N05AH04
ATC
quetiapine; oral
3.2
13.9
66
246
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
3.1
13.8
72
283
R06.0
ICD-10 Finland
Dyspnoea
2.7
13.7
101
479
Z50.1
ICD-10 Finland
Other physical therapy
5.0
13.7
31
68
R52.0
ICD-10 Finland
Acute pain
6.5
13.6
23
38
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
13.6
65
243
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.8
13.2
44
130
A02BC03
ATC
lansoprazole; oral
2.6
13.1
110
553
G44.2
ICD-10 Finland
Tension-type headache
3.2
13.0
59
213
J01MA14
ATC
moxifloxacin; systemic
3.8
12.9
44
132
ZXE10
NOMESCO Finland
More than one and less than three hours
2.5
12.8
129
707
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.7
12.8
31
72
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.5
12.7
154
916
J01MA12
ATC
levofloxacin; systemic
2.8
12.7
79
341
R53
ICD-10 Finland
Malaise and fatigue
2.6
12.6
96
459
M03BC01
ATC
orphenadrine (citrate); systemic
2.7
12.6
88
403
M48.0
ICD-10 Finland
Spinal stenosis
3.4
12.6
51
172
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.5
12.0
103
520
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
4.5
11.8
30
72
N06AA10
ATC
nortriptyline; systemic
10.7
11.7
22
22
G50.0
ICD-10 Finland
Trigeminal neuralgia
67.8
11.7
13
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
5.4
11.7
24
48
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
11.6
143
847
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.5
11.4
43
138
TAC99
NOMESCO Finland
Other blockade for chronic pain
36.6
11.4
14
*
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
5.9
11.3
21
38
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.7
11.3
75
333
J01FF01
ATC
clindamycin; systemic
2.5
11.2
97
489
K30
ICD-10 Finland
Functional dyspepsia
3.3
11.2
48
167
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.2
11.2
31
80
N05CF01
ATC
zopiclone; oral
2.4
11.2
115
628
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.8
11.1
37
109
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
4.8
10.7
25
56
M54.9
ICD-10 Finland
Dorsalgia, unspecified
3.1
10.7
50
183
M01AB55
ATC
diclofenac, combinations; oral
4.1
10.6
31
83
N06AB04
ATC
citalopram; systemic
2.6
10.6
75
343
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
10.5
95
487
M01AH03
ATC
valdecoxib; oral
4.3
10.5
28
70
TAC00
NOMESCO Finland
Peripheral nerve block
+∞
10.5
10
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.3
10.5
44
151
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
5.0
10.4
23
49
UJF32
NOMESCO Finland
Coloscopy
2.4
10.3
92
468
M01AB05
ATC
diclofenac; systemic, rectal
2.4
10.3
206
1473
L03
ICPC
Low back symptom/complaint
2.4
10.2
91
463
D07AD01
ATC
clobetasol; topical
2.7
10.1
62
263
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.2
10.1
28
72
WX110
NOMESCO Finland
Infiltration anesthesia
2.4
10.0
213
1555
L28
ICPC
Limited function/disability (L)
2.6
10.0
67
298
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
11.2
9.9
18
17
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.4
9.8
38
124
G58.9
ICD-10 Finland
Mononeuropathy, unspecified
57.0
9.7
11
*
G47.3
ICD-10 Finland
Sleep apnoea
2.4
9.7
85
428
A03FA01
ATC
metoclopramide; systemic, rectal
2.4
9.7
80
392
R60.0
ICD-10 Finland
Localized oedema
3.0
9.6
47
176
L01
ICPC
Neck symptom/complaint
2.7
9.6
59
250
R42
ICD-10 Finland
Dizziness and giddiness
2.4
9.6
80
393
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
9.5
133
812
A11
ICPC
Chest pain NOS
3.3
9.5
38
126
M01AH02
ATC
rofecoxib; oral
2.9
9.5
50
195
R02
ICPC
Shortness of breath/dyspnoea
2.9
9.5
49
189
R20.2
ICD-10 Finland
Paraesthesia of skin
3.8
9.5
30
85
M54.8
ICD-10 Finland
Other dorsalgia
5.0
9.5
21
45
H02AB06
ATC
prednisolone; systemic
2.2
9.4
150
963
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
9.3
92
488
P01AB01
ATC
metronidazole; oral, rectal
2.2
9.2
134
829
A02BA04
ATC
nizatidine; systemic
3.6
9.2
32
97
ZXE00
NOMESCO Finland
One hour or less
2.2
9.2
125
753
M01AH05
ATC
etoricoxib; oral
2.2
9.1
187
1321
SPAT1229
SPAT
Assessment of need for aid
3.6
9.1
32
98
R29
ICPC
Respiratory symptom/complaint other
3.7
9.0
30
88
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.4
9.0
80
404
N05BA04
ATC
oxazepam; oral
2.3
8.9
89
473
L02
ICPC
Back symptom/complaint
3.0
8.8
42
155
J02AC01
ATC
fluconazole; systemic
2.1
8.8
121
729
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.7
8.8
55
235
M01AH01
ATC
celecoxib; oral
2.5
8.8
63
288
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.8
8.8
28
80
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.7
8.8
54
229
P76
ICPC
Depressive disorder
3.9
8.7
26
71
N05BA01
ATC
diazepam; systemic, rectal
2.7
8.6
53
224
R03AC02
ATC
salbutamol; inhalant
2.1
8.6
169
1162
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
2.1
8.6
166
1134
J01MA02
ATC
ciprofloxacin; systemic
2.1
8.6
127
785
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
3.0
8.5
39
141
C01DA14
ATC
isosorbide mononitrate; oral
2.6
8.4
54
233
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.1
8.4
159
1074
L17
ICPC
Foot/toe symptom/complaint
2.2
8.4
95
529
G58.8
ICD-10 Finland
Other specified mononeuropathies
+∞
8.4
8
*
G43.9
ICD-10 Finland
Migraine, unspecified
4.0
8.3
24
64
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
8.2
94
524
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
4.3
8.2
22
55
K59.09
ICD-10 Finland
Constipation, unspecified
3.5
8.2
29
89
R52.1
ICD-10 Finland
Chronic intractable pain
17.8
8.1
12
7
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
8.1
43
168
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
8.0
59
272
S22.3
ICD-10 Finland
Fracture of rib
3.2
8.0
33
112
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.4
7.9
20
48
N06AB06
ATC
sertraline; oral
2.9
7.8
38
142
WX250
NOMESCO Finland
Intercostal blockade
46.3
7.8
9
*
WZC00
NOMESCO Finland
Treatment plan or consultation
2.1
7.8
113
689
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.4
7.7
64
312
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.0
7.7
22
58
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.3
7.7
20
49
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.8
7.7
40
155
SPAT1153
SPAT
Removal of sutures
2.1
7.7
100
585
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
25.8
7.6
10
*
A02BA02
ATC
ranitidine; systemic
2.3
7.6
69
349
Z02.7
ICD-10 Finland
Issue of medical certificate
3.3
7.5
29
94
N05CF02
ATC
zolpidem; oral
2.4
7.5
60
287
N06AX26
ATC
vortioxetine; oral
3.4
7.5
28
89
ZXD05
NOMESCO Finland
Urgent procedure
2.1
7.4
95
550
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.0
7.4
35
128
M54
ICD-10 Finland
Dorsalgia
2.7
7.4
43
176
AA1AD
NOMESCO Finland
CT of head and brain
2.1
7.4
85
472
R96
ICPC
Asthma
2.9
7.4
36
134
N05BA12
ATC
alprazolam; oral
2.9
7.4
37
140
ZXA00
NOMESCO Finland
Right side
2.1
7.3
86
482
TAC02
NOMESCO Finland
Block of intercostal nerve
+∞
7.3
7
*
N01
ICPC
Headache
2.8
7.3
40
159
R03BB04
ATC
tiotropium bromide; inhalant
2.9
7.3
37
141
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
7.3
84
467
N02AC04
ATC
dextropropoxyphene; oral
4.1
7.3
20
51
C07AB07
ATC
bisoprolol; oral
2.0
7.3
152
1046
M70.6
ICD-10 Finland
Trochanteric bursitis
2.5
7.3
48
210
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.9
7.2
35
130
D06
ICPC
Abdominal pain localized other
3.1
7.2
32
113
G56.2
ICD-10 Finland
Lesion of ulnar nerve
20.6
7.2
10
5
L13
ICPC
Hip symptom/complaint
2.3
7.2
66
335
L84
ICPC
Back syndrome without radiat pain
3.7
7.2
23
66
M01AX17
ATC
nimesulide; oral
2.1
7.1
80
440
N02BE01
ATC
paracetamol; systemic, rectal
3.2
7.1
263
2242
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.7
7.0
40
162
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.8
7.0
22
62
N06AX12
ATC
bupropion; oral
3.5
7.0
25
77
L04
ICPC
Chest symptom/complaint
3.5
7.0
25
77
Z71.8
ICD-10 Finland
Other specified counselling
2.0
7.0
98
586
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.7
7.0
39
157
J01DA01
ATC
[U] cefalexin
2.0
6.9
182
1345
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.3
6.9
26
83
J20
ICD-10 Finland
Acute bronchitis
2.7
6.9
38
152
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.0
6.8
31
111
A03FA02
ATC
cisapride; oral, rectal
3.1
6.8
29
100
N05CD07
ATC
temazepam; oral
2.6
6.8
43
184
M47.9
ICD-10 Finland
Spondylosis, unspecified
7.5
6.8
15
21
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
6.8
51
237
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.8
6.8
35
135
Z72.0
ICD-10 Finland
Tobacco use
6.7
6.7
16
25
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.2
6.7
18
45
X59
ICD-10 Finland
Exposure to unspecified factor
2.3
6.7
60
301
M03BC51
ATC
orphenadrine, combinations; systemic
2.0
6.7
89
521
R4110
NOMESCO Finland
Physiotherapy
2.0
6.7
90
529
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.1
6.7
78
435
R07.2
ICD-10 Finland
Precordial pain
9.0
6.6
13
15
M54.2
ICD-10 Finland
Cervicalgia
3.0
6.6
31
113
M50.3
ICD-10 Finland
Other cervical disc degeneration
10.4
6.6
12
12
R60.9
ICD-10 Finland
Oedema, unspecified
3.6
6.6
22
65
SPAT1254
SPAT
Administration of medicine
2.4
6.6
48
220
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
6.5
114
731
M54.1
ICD-10 Finland
Radiculopathy
4.1
6.5
18
46
C08CA13
ATC
lercanidipine; oral
2.4
6.5
49
227
M01AC06
ATC
meloxicam; systemic, rectal
1.9
6.5
113
723
J01DB01
ATC
cefalexin; oral
2.3
6.5
239
1969
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
7.7
6.5
14
19
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.9
6.5
135
917
G04CA02
ATC
tamsulosin; oral
2.1
6.5
75
416
GAC46
NOMESCO Finland
Partial decortication of pleura
71.4
6.5
7
*
J93.1
ICD-10 Finland
Other spontaneous pneumothorax
71.4
6.5
7
*
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
4.2
6.4
17
42
N17
ICPC
Vertigo/dizziness
2.5
6.4
43
189
Z71.9
ICD-10 Finland
Counselling, unspecified
3.2
6.4
26
87
M02AA10
ATC
ketoprofen; topical
2.3
6.3
50
237
R50.9
ICD-10 Finland
Fever, unspecified
2.3
6.3
50
238
GAE06
NOMESCO Finland
Excision of lesion of chest wall
+∞
6.3
6
*
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
6.0
6.2
16
28
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.1
6.2
27
94
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.9
6.2
126
847
Z01.2
ICD-10 Finland
Dental examination
1.9
6.1
130
885
K08.80
ICD-10 Finland
Toothache NOS
2.8
6.0
30
113
A02BC04
ATC
rabeprazole; oral
2.7
6.0
34
137
C08CA01
ATC
amlodipine; oral
1.9
6.0
118
781
L12
ICPC
Hand/finger symptom/complaint
2.3
6.0
50
242
WX002
NOMESCO Finland
Sedation and analgesia
2.1
6.0
62
328
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
3.9
6.0
18
49
L86
ICPC
Back syndrome with radiating pain
3.4
6.0
22
69
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
138
693
2.92
17.54
3.2
2.6
66.45
64.01
u/l
0.06
128
638
221
1524
2.98
13.93
5.4
4.3
35.14
544.88
e6/l
—
7
25
203
1343
2.76
13.82
6.0
5.0
6.61
6.64
mmol/l
0.06
197
1252
178
1110
2.60
13.59
18.1
13.0
1.24
1.28
inr
0.26
75
329
186
1192
2.60
13.29
6.7
6.7
10.90
11.69
umol/l
0.26
180
1134
200
1329
2.68
13.22
9.0
9.1
4.30
4.14
e9/l
0.33
174
1171
142
817
2.47
12.60
3.6
3.1
—
—
—
0
0
102
507
2.57
12.35
1.8
1.7
1.02
1.42
mg/l
1.41
79
393
239
1779
3.09
11.96
9.5
7.4
75.65
77.29
u/l
0.36
229
1654
118
651
2.38
11.19
3.5
3.0
0.11
0.55
e6/l
3.14
93
492
168
1084
2.33
10.99
7.7
5.7
28.12
27.29
%
0.44
158
1024
174
1140
2.34
10.97
7.6
7.0
1.21
1.22
mmol/l
0.25
140
977
79
365
2.61
10.96
3.8
3.6
0.80
0.82
mmol/l
0.83
73
344
153
952
2.31
10.87
4.3
4.8
35.70
35.58
g/l
0.09
147
892
163
1068
2.22
9.89
7.4
5.5
56.26
57.91
%
1.09
152
1009
170
1134
2.23
9.85
4.0
3.5
0.00
0.00
estimate
-0.00
51
230
87
443
2.39
9.66
5.1
3.7
36.59
218.66
ng/l
2.02
63
358
170
1142
2.20
9.58
5.3
4.7
0.00
0.00
estimate
-0.00
49
212
225
1705
2.50
9.38
5.5
3.8
12.51
11.69
mm/h
0.33
213
1545
148
949
2.16
9.30
2.2
2.1
76.45
78.59
nmol/l
0.37
137
828
170
1158
2.15
9.04
4.0
3.5
0.00
0.00
estimate
-0.00
45
204
127
787
2.10
8.52
2.6
3.4
2.35
2.36
mmol/l
0.24
116
683
120
737
2.08
8.16
3.4
3.1
28.48
30.18
u/l
0.45
114
700
56
250
2.54
8.16
2.3
1.8
—
—
—
0
0
20
47
4.50
8.08
3.4
2.3
16.20
16.07
%
0.04
11
22
137
886
2.05
8.07
5.9
3.5
21.42
36.67
ng/l
1.60
108
615
72
367
2.29
7.80
2.3
1.9
—
—
—
0
0
153
1044
2.00
7.62
7.0
6.1
1.21
1.21
mmol/l
0.30
140
941
135
883
2.00
7.57
4.3
3.6
—
—
—
0
0
103
612
2.07
7.54
4.4
3.8
0.00
0.00
estimate
-0.00
49
210
108
659
2.03
7.31
2.7
2.1
157.84
194.36
u/l
0.42
102
620
53
248
2.40
6.94
2.3
1.8
—
—
—
0
0
68
357
2.19
6.79
1.4
1.2
29.31
29.01
iu/ml
0.01
16
116
65
338
2.19
6.63
1.3
1.2
2.45
10.52
u/ml
1.78
21
137
50
233
2.39
6.59
5.4
3.3
—
—
—
0
0
96
587
1.96
6.30
2.5
2.7
343.64
7222.22
umol/l
2.66
84
516
47
221
2.35
6.06
2.6
2.5
27.08
29.27
u/l
0.28
39
191
42
191
2.41
5.83
4.4
3.5
1.22
1.22
mmol/l
0.07
36
171
39
173
2.45
5.71
4.0
3.0
99.24
218.73
ng/l
3.59
34
160
13
20
6.75
5.62
1.4
1.4
—
—
—
0
0
86
526
1.91
5.54
2.7
1.9
2.81
3.04
mg/l
0.51
80
446
54
282
2.13
5.39
2.5
2.1
22.37
22.51
%
0.02
44
247
132
930
1.78
5.34
2.2
1.9
94.91
94.92
pmol/l
0.00
67
474
65
366
2.00
5.30
2.8
3.0
4.43
2.02
e6/l
0.37
36
198
79
477
1.91
5.26
1.4
1.2
1.02
1.46
u/ml
0.46
23
142
17
49
3.63
5.26
1.2
1.2
—
—
—
0
0
29
117
2.65
5.15
1.1
1.2
544.41
198.56
u/ml
0.34
29
103
213
1743
1.87
5.04
4.3
3.6
14.53
14.75
pmol/l
0.60
196
1558
31
132
2.51
4.94
3.2
3.3
2.53
2.01
mmol/l
0.42
22
99
34
153
2.39
4.82
2.4
1.5
—
—
—
0
0
143
1054
1.71
4.77
3.0
2.7
—
—
—
0
0
76
468
1.85
4.71
4.1
3.8
1.02
1.02
kg/l
0.78
18
56
10
14
7.36
4.69
1.3
1.4
—
—
—
0
0
9
11
8.40
4.59
1.7
1.5
—
—
—
0
0
101
682
1.74
4.58
3.6
3.0
1432.26
1214.52
ng/l
0.24
80
571
13
27
4.99
4.55
1.8
1.5
—
—
—
0
0
8
8
10.24
4.54
1.6
1.5
—
—
—
0
0
262
2333
2.47
4.53
25.5
13.6
20.02
23.98
mg/l
1.46
233
1825
74
458
1.83
4.49
1.7
1.7
389.85
439.67
pmol/l
1.09
60
370
68
412
1.85
4.41
1.9
1.6
1280.91
1204.39
nmol/l
0.26
54
304
15
45
3.46
4.39
1.1
1.2
—
1.08
—
0
5
8
9
9.10
4.30
1.6
1.4
—
—
—
0
0
15
39
4.00
4.26
1.9
1.8
—
—
—
0
0
17
57
3.11
4.20
1.4
1.4
—
—
—
0
0
13
30
4.49
4.18
3.3
2.3
4.22
4.69
e9/l
0.21
13
30
19
69
2.88
4.11
1.8
1.8
—
—
—
0
0
25
108
2.44
3.88
1.1
1.0
—
—
—
0
0
13
33
4.08
3.84
4.1
2.8
60.08
57.88
%
0.20
13
33
16
55
3.02
3.80
2.3
1.7
—
—
—
0
0
63
390
1.79
3.78
2.7
2.8
1.06
1.04
e6/l
0.01
34
222
12
31
3.99
3.53
1.7
1.6
—
—
—
0
0
15
52
2.99
3.52
1.3
1.5
—
—
—
0
0
15
52
2.99
3.52
2.1
1.4
—
—
—
0
0
15
52
2.99
3.52
1.3
1.5
—
—
—
0
0
44
249
1.91
3.50
6.8
10.0
5.29
5.02
kpa
1.57
44
238
16
58
2.86
3.48
2.3
1.7
—
—
—
0
0
44
250
1.90
3.45
6.7
10.0
1.33
1.20
mmol/l
0.10
36
203
15
53
2.93
3.41
1.7
1.9
2904.13
8107.64
u/l
—
8
13
17
65
2.72
3.37
5.2
2.5
—
—
—
0
0
243
2163
1.82
3.29
5.5
4.3
1.85
1.95
mu/l
0.68
225
1951
50
301
1.80
3.28
6.0
7.2
104.72
104.02
mmol/l
0.49
50
301
10
24
4.28
3.22
1.2
1.1
—
—
—
0
0
36
197
1.95
3.16
2.4
2.5
5.14
5.85
ug/l
0.15
31
174
125
959
1.54
3.15
3.3
2.5
94.56
127.12
ug/l
1.60
115
864
12
35
3.53
3.14
1.7
1.6
—
—
—
0
0
11
30
3.77
3.12
1.7
1.6
—
—
—
0
0
65
429
1.67
3.08
2.5
2.8
2.44
2.46
mmol/l
0.63
59
375
17
70
2.52
2.94
4.2
3.7
—
3.19
—
0
7
36
203
1.88
2.90
7.3
11.4
123.22
120.73
g/l
0.32
36
197
6
9
6.78
2.88
2.3
5.1
—
—
—
0
0
32
174
1.94
2.87
4.4
2.9
64.47
63.33
ml/min/173m2
0.04
15
73
35
197
1.88
2.83
3.7
3.7
1.79
2.34
mmol/l
0.30
30
159
183
1544
1.51
2.83
4.1
3.0
53.65
49.90
u/l
0.20
169
1428
12
39
3.17
2.80
1.9
1.6
—
—
—
0
0
8
19
4.30
2.70
2.3
1.7
—
—
—
0
0
25
129
2.03
2.59
10.0
11.4
25.56
24.35
mmol/l
1.11
25
122
14
56
2.58
2.57
1.4
1.7
310.93
308.21
mu/l
0.01
14
56
246
2242
1.70
2.49
21.2
12.9
81.36
80.18
ml/min/173m2
0.37
215
1833
16
70
2.36
2.46
1.1
1.2
—
—
—
0
0
16
70
2.36
2.46
1.1
1.2
—
—
—
0
0
54
367
1.58
2.26
1.6
1.5
—
—
—
0
0
7
19
3.75
2.16
1.3
1.2
—
—
—
0
0
24
132
1.89
2.11
1.5
1.3
—
—
—
0
0
91
703
1.43
2.05
4.3
3.5
9.88
7.21
mg/mmol
0.31
61
434
266
2506
1.88
2.01
14.3
10.1
29.38
25.90
u/l
0.45
261
2408
39
253
1.63
1.97
2.3
1.7
1.55
1.49
%
0.26
34
223
5
12
4.22
1.83
1.0
1.2
—
—
—
0
0
8
30
2.71
1.73
1.0
1.2
—
—
—
0
0
7
24
2.96
1.73
1.1
1.6
16.93
17.01
ug/l
—
7
24
5
13
3.89
1.72
1.0
1.2
—
—
—
0
0
12
55
2.23
1.70
1.1
1.2
—
—
—
0
0
16
83
1.98
1.68
4.5
2.3
—
—
—
0
0
70
534
1.41
1.67
1.5
1.5
20.17
21.31
nmol/l
0.20
60
451
236
2184
1.46
1.65
6.4
5.4
40.16
39.70
mmol/mol
0.30
221
2018
10
44
2.32
1.57
1.1
1.3
4.40
4.21
e6/l
—
5
33
18
100
1.85
1.57
1.4
1.9
—
—
—
0
0
13
64
2.08
1.56
1.7
1.2
—
—
—
0
0
5
15
3.37
1.53
1.6
1.2
—
—
—
0
0
22
134
1.70
1.44
2.2
1.6
—
—
—
0
0
23
142
1.67
1.43
1.2
1.2
57.62
137.79
iu/ml
—
5
61
12
219
0.53
1.36
2.2
1.7
—
—
—
0
0
244
2295
1.43
1.33
5.0
4.4
6.07
5.97
mmol/l
0.53
222
2072
6
24
2.53
1.31
1.0
1.1
—
—
—
0
0
36
256
1.46
1.25
2.9
4.2
3.10
51.18
ug/l
0.90
28
211
158
1418
1.26
1.11
3.4
2.9
—
—
—
0
0
5
21
2.40
1.09
2.0
2.6
—
—
—
0
0
9
46
1.99
1.04
1.1
1.2
104.56
15.53
u/l
—
9
39
21
307
0.66
1.04
5.0
4.3
27.69
31.24
%
0.69
13
195
5
23
2.19
0.98
1.2
1.1
—
—
—
0
0
13
77
1.72
0.97
1.2
1.8
—
—
—
0
0
12
70
1.75
0.94
1.4
1.4
—
—
—
0
0
6
28
2.17
0.92
1.7
1.1
—
—
—
0
0
67
557
1.26
0.89
3.4
2.3
—
—
—
0
0
8
44
1.84
0.86
1.9
1.3
—
—
—
0
0
14
90
1.58
0.79
5.3
9.3
1.73
1.46
%
0.53
14
84
10
59
1.72
0.77
1.2
1.2
—
—
—
0
0
268
2609
1.43
0.73
34.7
20.1
40.24
40.29
%
0.05
257
2464
15
101
1.51
0.71
1.6
2.5
0.64
0.65
%
0.07
15
101
5
26
1.94
0.71
3.4
2.0
—
—
—
0
0
5
27
1.87
0.68
3.0
1.5
—
—
—
0
0
5
27
1.87
0.68
3.0
1.5
—
—
—
0
0
17
119
1.46
0.68
1.2
1.4
—
—
—
0
0
5
30
1.68
0.61
3.4
1.5
—
—
—
0
0
5
30
1.68
0.61
3.4
1.5
—
—
—
0
0
15
105
1.45
0.61
1.6
2.4
0.96
1.29
%
1.08
15
105
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
231
2227
1.19
0.54
4.2
3.9
1.59
1.28
mmol/l
4.12
211
2036
5
31
1.62
0.43
2.6
2.9
103.80
105.68
mmol/l
—
5
31
5
33
1.52
0.41
1.0
1.2
—
—
—
0
0
26
214
1.24
0.41
1.8
1.9
—
—
—
0
0
5
35
1.44
0.39
1.0
1.1
—
—
—
0
0
9
66
1.38
0.39
1.2
1.1
—
12.84
—
0
8
9
66
1.38
0.39
1.2
1.1
—
—
—
0
0
236
2298
1.15
0.38
4.6
4.3
1.33
1.47
mmol/l
6.47
216
2106
28
235
1.21
0.38
1.9
1.9
—
—
—
0
0
87
803
1.12
0.36
4.2
4.9
1.52
2.60
ug/l
1.66
79
714
6
42
1.44
0.36
1.2
1.5
—
—
—
0
0
6
44
1.37
0.34
4.0
1.8
—
—
—
0
0
6
44
1.37
0.34
4.0
1.8
—
—
—
0
0
6
88
0.68
0.33
1.5
1.5
—
—
—
0
0
12
97
1.25
0.23
2.0
2.0
—
—
—
0
0
30
267
1.14
0.22
10.2
6.5
—
—
—
0
0
68
636
1.09
0.22
1.7
1.6
1.79
1.37
mmol/l
1.61
56
521
5
41
1.22
0.22
1.2
1.1
0.46
0.83
nmol/l
—
5
31
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
235
2312
1.09
0.19
4.8
4.3
4.40
4.67
mmol/l
3.82
215
2126
36
335
1.09
0.13
1.6
1.4
—
—
—
0
0
240
2372
1.07
0.13
5.3
4.8
2.58
2.77
mmol/l
2.51
222
2173
6
71
0.84
0.07
1.3
1.4
—
—
—
0
0
6
70
0.85
0.07
2.7
1.8
—
—
—
0
0
10
89
1.13
0.07
1.4
1.8
—
—
—
0
0
48
464
1.04
0.06
3.0
3.1
0.56
0.75
ug/l
1.69
35
315
65
638
1.02
0.03
4.2
4.3
24.00
20.93
%
0.52
26
311
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.6
—
—
—
0
0
5
51
0.98
-0.00
1.2
1.3
—
—
—
0
0
5
49
1.02
-0.00
3.6
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
42.67
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
0.31
—
0
6
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
7
73
0.96
-0.00
1.4
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_ICNEUROP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ICNEUROP | 1.431 [1.19, 1.73] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 163 out of 876 females with G6_ICNEUROP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ICNEUROP | 1.58 [1.33, 1.88] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 185 out of 723 males with G6_ICNEUROP died.
Mortality risk
Mortality risk for people of age
years, who have G6_ICNEUROP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.147% | 0.338% |
| 5 | 0.74% | 1.76% |
| 10 | 1.955% | 4.785% |
| 15 | 3.823% | 9.4% |
| 20 | 6.455% | 15.462% |
Relationships between endpoints
↥Index endpoint: G6_ICNEUROP – Intercostal neuropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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