≡ Risteys
R14

Documentation Changelog GitHub Contact & Feedback

Osteomalacia

DOID EFO Endpoint Browser PheWeb

M13_OSTEOMALACIA

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M83
  • Hospital discharge: ICD-9 — 2682A
  • Hospital discharge: ICD-8 — 2652
  • Cause of death: ICD-10 — M83
  • Cause of death: ICD-9 — 2682A
  • Cause of death: ICD-8 — 2652

2 out of 7 registries used, show all original rules.

348

4. Check minimum number of events

None

348

5. Include endpoints

None

348

6. Filter based on genotype QC (FinnGen only)

312

Control definitions (FinnGen only)

Control exclude
M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M80-M85
Name in latin
Osteomalacia adultorum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2358 1342 1003
Only index persons 2066 1151 915
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.03
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 45.50 47.04 43.34
Only index persons 43.40 44.63 41.87

-FinnGen-

Key figures

All Female Male
Number of individuals 312 205 107
Unadjusted period prevalence (%) 0.06 0.07 0.05
Median age at first event (years) 45.25 45.63 44.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
319
Matched controls
3190
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M83.2
ICD-10 Finland
Adult osteomalacia due to malabsorption
+∞
164.2
143
*
M83.9
ICD-10 Finland
Adult osteomalacia, unspecified
+∞
59.2
55
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
7.1
54.6
103
200
M83.5
ICD-10 Finland
Other drug-induced osteomalacia in adults
+∞
35.0
33
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
4.7
29.0
81
215
S83.5
ICD-10 Finland
Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
7.9
26.0
38
54
M83.8
ICD-10 Finland
Other adult osteomalacia
+∞
25.3
24
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
5.9
24.5
48
93
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.3
21.4
108
424
NGE35
NOMESCO Finland
Plastic repair of ligament of knee not using prosthetic material, anterior cruciate, arthroscopic
9.1
21.3
27
32
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
5.7
20.2
40
78
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
7.2
20.0
31
47
S83.2
ICD-10 Finland
Tear of meniscus, current
4.8
19.6
49
117
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
3.8
18.4
65
201
M83.4
ICD-10 Finland
Aluminium bone disease
+∞
17.9
17
*
M83.3
ICD-10 Finland
Adult osteomalacia due to malnutrition
+∞
16.8
16
*
M83.0
ICD-10 Finland
Puerperal osteomalacia
+∞
16.8
16
*
M83.1
ICD-10 Finland
Senile osteomalacia
+∞
13.6
13
*
N02AX02
ATC
tramadol; systemic, rectal
2.4
12.7
167
1013
X58
ICD-10 Finland
Exposure to other specified factors
2.7
11.7
72
306
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
11.5
115
615
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.2
10.5
46
161
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.9
10.5
56
220
M25.5
ICD-10 Finland
Pain in joint
2.2
10.3
137
816
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
3.7
10.2
34
100
ZXA05
NOMESCO Finland
Left side
2.4
9.9
89
450
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.1
9.8
168
1098
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
7.3
9.5
22
32
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
9.5
138
846
N03AX16
ATC
[U] pregabalin
2.3
8.8
86
448
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.9
8.8
46
178
ZXD20
NOMESCO Finland
Day surgery
2.6
8.7
54
229
R10.0
ICD-10 Finland
Acute abdomen
4.7
8.2
19
42
B01AB05
ATC
enoxaparin; parenteral
2.0
7.6
108
645
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
7.6
124
778
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.1
7.5
97
560
M01AH05
ATC
etoricoxib; oral
2.0
7.5
224
1721
ZXA00
NOMESCO Finland
Right side
2.1
7.4
90
508
M93.1
ICD-10 Finland
Kienböck disease of adults
+∞
7.3
7
*
26520
ICD-8 Finland
Vitamin D deficiency, Osteomalacia
+∞
7.3
7
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.0
7.2
32
113
ZXE20
NOMESCO Finland
More than three and less than five hours
2.5
7.1
50
224
N02AA05
ATC
oxycodone; systemic
2.3
7.1
62
306
A02BC02
ATC
pantoprazole; systemic
2.0
7.1
225
1746
J01DB01
ATC
cefalexin; oral
2.4
7.1
275
2301
S09
ICPC
Infected finger/toe
4.5
7.0
17
39
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
7.0
127
820
S18
ICPC
Laceration/cut
1.9
6.9
156
1080
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.4
6.8
17
40
M23.8
ICD-10 Finland
Other internal derangements of knee
3.7
6.7
21
59
M79.6
ICD-10 Finland
Pain in limb
1.8
6.5
155
1087
L15
ICPC
Knee symptom/complaint
2.0
6.5
91
538
ZXD05
NOMESCO Finland
Urgent procedure
1.9
6.5
108
677
X59
ICD-10 Finland
Exposure to unspecified factor
2.1
6.3
70
379
M01AH01
ATC
celecoxib; oral
2.1
6.3
66
350
2682A
ICD-9 Finland
Vitamin D deficiency, Osteomalacia, unspecified[OSTEOMALACIA]
+∞
6.3
6
*
M01AE02
ATC
naproxen; oral, rectal
1.8
6.2
195
1479
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
2.5
6.2
41
179
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
4.0
6.1
17
44

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
171
1178
1.97
8.12
15.2
11.5
1.22
1.18
inr
0.37
136
971
62
303
2.30
7.29
1.7
1.6
—
—
—
0
0
199
1477
1.92
7.23
6.4
6.3
1.95
2.01
e9/l
0.21
181
1307
210
1590
1.94
7.15
6.3
5.0
6.59
6.62
mmol/l
0.06
199
1497
200
1501
1.89
6.87
6.4
6.5
0.18
0.19
e9/l
0.27
180
1317
195
1452
1.88
6.86
6.4
6.3
0.04
0.04
e9/l
0.05
177
1247
194
1447
1.87
6.74
6.4
6.2
0.53
0.56
e9/l
1.04
176
1245
135
916
1.82
6.23
5.9
5.7
—
—
—
0
0
119
779
1.84
6.15
3.8
2.9
—
—
—
0
0
180
1341
1.79
5.99
6.2
6.0
55.50
56.84
%
0.84
175
1284
42
193
2.35
5.65
2.1
2.5
69.63
70.85
e9/l
0.08
32
137
18
52
3.61
5.54
3.1
2.0
4.63
5.35
mmol/24h
0.41
18
44
52
265
2.15
5.47
1.8
2.5
1.69
1.78
%
0.36
47
241
126
872
1.74
5.22
3.6
3.1
48.85
38.63
e6/l
0.14
97
653
172
1301
1.70
5.11
3.4
2.7
—
—
estimate
—
0
0
106
703
1.76
5.08
4.0
5.0
—
—
—
0
0
174
1328
1.68
4.94
6.4
6.0
2.71
2.89
%
0.52
169
1246
93
599
1.78
4.90
3.1
2.5
5.56
5.72
e6/l
0.05
87
544
174
1333
1.67
4.83
6.5
6.1
8.51
8.65
%
0.31
169
1256
60
339
1.95
4.76
8.2
5.2
1.01
1.03
mmol/l
0.18
55
313
106
715
1.72
4.73
3.4
2.7
328.08
336.33
umol/l
0.36
91
643
115
794
1.70
4.71
6.5
4.0
7.39
7.40
ph
0.36
87
565
50
267
2.03
4.64
5.7
9.7
7.43
7.42
ph
0.40
28
156
30
130
2.44
4.59
3.2
7.7
—
—
—
0
0
49
261
2.04
4.58
5.5
9.8
0.48
0.68
mmol/l
0.08
42
226
27
118
2.41
4.07
1.6
1.8
—
—
—
0
0
197
1599
1.61
4.02
10.8
9.8
3.82
4.03
e9/l
0.81
178
1406
191
1542
1.59
3.96
5.3
3.6
0.00
0.00
estimate
-0.00
41
322
192
1554
1.59
3.93
5.4
3.6
0.00
0.00
estimate
-0.00
42
325
99
685
1.65
3.91
5.9
3.9
—
—
—
0
0
119
862
1.61
3.90
3.5
2.6
53.79
62.07
u/l
0.86
112
810
193
1567
1.59
3.87
5.4
3.7
0.00
0.00
estimate
-0.00
43
296
47
262
1.93
3.87
3.5
3.1
7.39
7.39
ph
0.05
24
154
27
121
2.35
3.86
1.6
1.8
—
—
—
0
0
27
121
2.35
3.86
1.6
1.8
—
—
—
0
0
137
1032
1.57
3.78
4.4
3.7
87.36
74.75
e6/l
0.11
97
702
23
99
2.43
3.59
1.5
1.5
—
—
—
0
0
105
754
1.59
3.51
3.4
2.9
0.43
0.44
e6/l
0.02
80
545
122
907
1.56
3.51
3.0
2.3
—
—
—
0
0
26
121
2.25
3.43
1.7
1.8
—
—
—
0
0
13
42
3.18
3.41
1.4
1.3
—
—
—
0
0
25
115
2.27
3.39
1.5
1.9
—
—
—
0
0
82
562
1.62
3.30
1.4
1.3
18.83
8.06
u/ml
0.40
33
226
58
367
1.71
3.16
2.6
2.0
—
—
—
0
0
164
1327
1.49
3.05
9.9
6.8
1.21
1.21
mmol/l
0.03
152
1157
86
608
1.57
3.02
1.5
1.3
22.50
31.23
iu/ml
0.54
31
177
28
142
2.07
3.01
6.6
9.6
24.36
24.99
mmol/l
0.32
28
135
155
1244
1.48
2.98
3.3
2.4
75.70
76.99
nmol/l
0.26
148
1124
148
1178
1.48
2.96
5.6
3.4
0.00
0.00
estimate
0.50
37
269
226
1964
1.52
2.86
4.6
3.8
—
20203.60
—
0
5
297
2771
2.04
2.74
21.6
13.8
22.49
21.06
mg/l
0.35
255
2245
240
2121
1.53
2.73
11.0
8.1
74.69
78.16
u/l
0.87
233
2014
18
79
2.35
2.73
2.5
2.2
—
—
—
0
0
61
407
1.62
2.72
3.1
2.2
2.41
2.37
g/l
0.16
56
374
247
2200
1.54
2.67
5.0
4.5
14.82
14.66
pmol/l
0.43
233
2036
153
1243
1.44
2.67
5.0
3.3
6.28
6.17
ph
0.54
89
721
65
443
1.59
2.65
1.5
1.4
282.50
567.52
titre
2.27
16
101
90
661
1.50
2.62
6.6
3.8
1.02
1.02
kg/l
0.01
57
436
10
30
3.41
2.62
2.8
2.1
13.10
13.36
%
—
10
30
9
25
3.67
2.59
2.2
2.6
—
—
—
0
0
6
11
5.53
2.55
1.7
2.5
—
—
—
0
0
165
1367
1.43
2.55
3.5
3.1
119.22
114.16
ug/l
0.11
157
1288
38
227
1.77
2.54
6.5
10.6
122.92
121.73
g/l
0.09
38
222
74
525
1.53
2.53
2.0
1.7
449.98
26233630.34
pmol/l
0.50
62
446
93
698
1.47
2.42
5.8
3.5
—
0.00
—
0
5
120
950
1.42
2.34
4.0
3.0
2.35
2.35
mmol/l
0.04
112
864
27
150
1.87
2.28
4.0
2.3
0.51
0.61
%
1.50
27
150
53
359
1.57
2.22
1.5
1.5
—
—
—
0
0
12
48
2.56
2.21
1.3
1.2
—
—
—
0
0
10
36
2.83
2.15
1.2
1.9
—
—
—
0
0
87
658
1.44
2.15
2.6
2.1
2.97
2.86
mg/l
0.13
82
579
19
95
2.06
2.15
1.5
1.4
290.82
290.61
ug/g
0.00
11
56
35
215
1.71
2.14
6.8
8.5
—
—
—
0
0
154
1290
1.37
2.10
12.2
10.3
0.00
0.00
e9/l
0.86
129
1066
10
37
2.76
2.09
1.9
2.1
—
—
—
0
0
14
63
2.28
2.04
2.6
12.5
1.67
1.24
mmol/l
0.32
14
55
56
392
1.52
2.03
1.4
1.2
—
—
—
0
0
55
384
1.52
2.02
2.3
1.6
1464.64
1208.60
nmol/l
0.46
46
291
107
851
1.39
1.98
3.2
3.0
—
0.12
—
0
17
108
866
1.37
1.89
3.9
3.0
0.00
0.01
estimate
0.80
35
257
33
207
1.66
1.89
5.3
3.3
—
—
—
0
0
6
17
3.58
1.84
1.3
2.6
21.38
19.15
mu/l
—
6
17
170
1466
1.34
1.84
8.2
6.7
10.20
10.79
umol/l
0.62
165
1403
24
142
1.75
1.70
2.9
1.7
18.11
4.28
iu/ml
—
7
27
5
14
3.61
1.62
1.2
1.1
116.20
199.55
mmol/24h
—
5
14
11
50
2.24
1.58
4.6
1.6
—
—
—
0
0
105
862
1.33
1.53
6.3
3.5
0.00
0.00
estimate
0.50
39
307
114
948
1.32
1.52
3.5
3.2
8.06
8.06
mmol/l
0.00
107
799
36
245
1.53
1.50
1.4
1.4
—
—
—
0
0
66
506
1.38
1.50
5.4
3.7
138.38
118.82
ng/l
0.09
49
375
69
534
1.37
1.48
3.7
2.5
2.44
2.44
mmol/l
0.13
63
477
82
653
1.34
1.47
1.9
1.7
0.72
1.24
mg/l
1.85
54
519
34
230
1.54
1.46
5.1
4.4
7.31
7.35
ph
0.26
25
162
7
28
2.53
1.46
1.4
1.1
—
—
—
0
0
6
22
2.76
1.44
1.5
1.1
124.50
97.09
pmol/l
—
6
22
24
150
1.65
1.42
6.8
8.2
24.28
24.84
mmol/l
0.22
24
150
136
1167
1.29
1.42
2.2
2.0
96.46
98.18
pmol/l
0.19
78
597
10
46
2.21
1.41
5.6
2.2
—
—
—
0
0
121
1026
1.29
1.37
5.0
3.5
23.73
90.05
ng/l
0.58
82
678
5
17
2.97
1.36
2.2
1.9
74.40
123.68
ng/l
—
5
17
11
54
2.07
1.34
1.5
1.7
—
—
—
0
0
18
106
1.74
1.32
2.2
2.1
7423.54
5601.50
u/l
—
9
44
94
778
1.30
1.27
1.7
1.6
20.22
21.31
nmol/l
0.36
87
655
9
45
2.03
1.24
7.8
2.9
5.26
4.99
kpa
—
9
45
9
45
2.03
1.24
7.8
2.9
8.59
8.79
kpa
—
9
45
29
198
1.51
1.22
1.4
1.2
82.71
270.05
u/ml
0.95
29
187
5
19
2.66
1.22
5.2
4.3
63.40
158.95
nmol/l
—
5
19
11
57
1.96
1.18
2.0
3.2
64.62
59.68
%
0.63
11
57
10
50
2.03
1.17
1.1
1.2
5.60
3.83
u/ml
—
5
18
8
39
2.08
1.16
2.0
1.2
—
—
—
0
0
8
39
2.08
1.16
1.9
3.3
5.36
5.03
e9/l
—
8
39
87
724
1.28
1.12
1.3
1.3
0.55
1.28
u/ml
2.19
25
210
298
2877
1.54
1.12
18.4
12.3
—
—
—
0
0
14
81
1.76
1.11
13.0
5.3
15.65
27.36
mg/l
2.54
14
70
14
81
1.76
1.11
13.0
5.3
29.04
44.06
mg/l
0.67
14
70
272
2588
1.35
1.09
6.2
5.4
1.84
1.89
mu/l
0.31
258
2419
11
60
1.86
1.04
2.3
1.8
—
—
—
0
0
79
656
1.27
1.04
1.7
1.4
2.03
2.44
g/l
1.37
49
414
53
417
1.32
1.04
3.2
2.8
1.70
2.61
e6/l
0.69
21
199
7
35
2.02
1.00
1.1
1.2
—
—
—
0
0
34
251
1.40
0.99
2.4
2.3
6.38
6.01
ph
1.28
24
155
19
125
1.55
0.96
8.7
13.8
15.65
15.88
%
0.11
19
119
9
51
1.79
0.95
4.6
2.8
11.01
8.15
pmol/l
—
9
51
279
2677
1.34
0.94
5.1
4.9
5.94
5.88
mmol/l
0.26
269
2508
24
168
1.46
0.93
1.1
1.1
—
—
—
0
0
6
28
2.16
0.92
1.3
1.2
—
—
—
0
0
130
1155
1.21
0.91
2.1
2.0
—
—
—
0
0
11
63
1.77
0.91
1.6
1.7
—
—
—
0
0
24
169
1.45
0.90
1.6
1.3
28.69
24.30
iu/l
0.30
24
150
16
103
1.58
0.89
1.4
1.4
—
—
—
0
0
277
2662
1.31
0.86
4.3
4.2
1.36
1.29
mmol/l
0.80
268
2494
61
503
1.26
0.85
3.6
2.7
542.46
528.48
mosm/kgh2o
0.20
52
434
31
232
1.37
0.85
3.8
3.0
—
—
—
0
0
8
45
1.80
0.85
1.4
1.2
69.98
45.76
mu/l
—
8
40
6
31
1.95
0.85
1.5
1.2
—
—
—
0
0
14
89
1.60
0.82
1.5
1.8
2.72
4.55
ug/l
0.20
14
82
6
32
1.89
0.82
1.7
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
2.4
—
14.47
—
0
15
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
0
26
0.00
0.79
0.0
1.8
—
0.61
—
0
26
288
2789
1.34
0.78
5.1
5.1
4.62
4.74
mmol/l
1.21
279
2641
10
59
1.72
0.76
1.9
1.3
—
—
—
0
0
5
24
2.10
0.75
1.6
3.6
—
—
—
0
0
7
38
1.86
0.74
1.1
1.3
—
—
—
0
0
5
25
2.02
0.73
1.4
1.4
—
—
—
0
0
21
285
0.72
0.72
1.7
1.8
3.49
3.49
mmol/l
0.00
16
214
32
248
1.32
0.72
1.2
1.2
—
—
—
0
0
13
85
1.55
0.70
1.7
2.8
12.53
11.66
mg/l
0.12
13
79
7
42
1.68
0.69
1.3
1.3
490.71
385.86
pmol/l
—
7
37
214
2024
1.17
0.66
3.9
3.4
47.91
43.35
u/l
0.42
209
1930
11
70
1.59
0.66
1.1
1.2
—
—
—
0
0
30
234
1.31
0.66
4.2
5.1
0.55
0.91
%
0.70
11
76
290
2823
1.30
0.64
5.7
5.6
2.68
2.80
mmol/l
1.61
280
2669
286
2780
1.28
0.64
4.9
4.9
1.44
1.48
mmol/l
1.02
277
2622
79
692
1.19
0.63
4.8
3.9
93.72
93.83
%
0.01
79
683
28
218
1.31
0.62
4.4
5.4
0.00
0.08
%
—
10
60
93
828
1.17
0.62
6.3
6.3
—
—
—
0
0
0
23
0.00
0.58
0.0
11.2
—
0.59
—
0
23
0
23
0.00
0.58
0.0
1.1
—
4.92
—
0
6
0
23
0.00
0.58
0.0
2.1
—
6.13
—
0
18
16
115
1.41
0.58
2.3
2.3
—
—
—
0
0
6
36
1.68
0.57
6.0
1.6
15.83
10.56
mmol/l
—
6
36
6
36
1.68
0.57
1.2
1.6
—
—
—
0
0
30
240
1.28
0.56
1.5
1.5
—
—
—
0
0
78
690
1.17
0.56
4.2
4.8
1.61
2.48
ug/l
0.96
72
632
97
874
1.16
0.55
3.7
3.3
47.07
47.71
mg/l
0.01
70
554
12
82
1.48
0.55
20.8
10.2
—
—
—
0
0
11
74
1.50
0.54
7.0
2.6
7.40
7.42
ph
0.54
11
74
246
2370
1.17
0.52
22.6
17.2
13.75
13.51
%
2.17
246
2353
22
171
1.31
0.51
4.7
2.6
134.27
131.76
g/l
0.18
22
166
14
190
0.72
0.51
1.0
1.1
—
—
—
0
0
98
890
1.15
0.50
4.1
4.0
9.74
7.86
mg/mmol
0.14
68
550
40
338
1.21
0.48
1.2
1.3
—
—
—
0
0
7
47
1.50
0.48
1.1
1.1
—
—
—
0
0
11
77
1.44
0.46
2.0
1.6
216.45
236.28
pmol/l
0.18
11
72
272
2651
1.18
0.44
6.4
6.0
39.16
38.85
mmol/mol
0.24
265
2521
115
1238
0.89
0.44
1.9
1.9
1.47
1.40
mmol/l
0.36
103
1048
5
32
1.57
0.42
1.2
1.9
—
—
—
0
0
5
33
1.52
0.41
1.6
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
0.19
—
0
8
0
15
0.00
0.41
0.0
2.6
—
0.93
—
0
15
0
16
0.00
0.41
0.0
1.4
—
242.31
—
0
16
5
34
1.48
0.40
5.4
3.9
13.18
3.60
nmol/l
—
5
34
56
497
1.15
0.40
1.7
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
27
224
1.22
0.40
3.2
5.1
0.90
0.62
%
—
10
68
10
71
1.42
0.39
1.1
1.1
—
—
—
0
0
10
71
1.42
0.39
1.1
1.1
—
—
—
0
0
5
35
1.44
0.39
2.0
2.1
0.72
0.90
%
—
5
21
36
309
1.19
0.38
1.3
1.5
—
—
—
0
0
32
272
1.20
0.38
1.7
2.0
0.00
0.05
estimate
—
6
64
37
426
0.85
0.37
2.9
3.1
0.79
0.73
ug/l
0.14
18
256
27
226
1.21
0.37
4.6
5.8
0.14
0.07
%
—
7
57
114
1217
0.90
0.37
2.9
3.2
—
—
—
0
0
12
90
1.35
0.36
1.3
1.2
—
—
—
0
0
6
43
1.40
0.35
1.7
1.2
—
—
—
0
0
6
43
1.40
0.35
1.7
1.2
—
—
—
0
0
6
43
1.40
0.35
1.7
1.2
—
—
—
0
0
6
43
1.40
0.35
1.7
1.2
—
—
—
0
0
12
91
1.33
0.34
2.0
2.7
—
—
—
0
0
12
91
1.33
0.34
2.4
2.5
1.52
1.39
mg/l
0.16
12
82
6
47
1.28
0.32
1.2
1.0
1.03
4.17
u/ml
—
6
26
14
110
1.29
0.32
1.6
1.2
—
—
—
0
0
40
357
1.14
0.28
1.6
1.5
—
—
—
0
0
8
64
1.26
0.27
1.1
1.3
—
—
—
0
0
29
254
1.16
0.26
4.2
4.6
67.97
25.16
ug/l
0.28
24
200
17
142
1.21
0.25
1.3
1.6
972.17
945.48
mu/l
0.03
12
118
19
162
1.18
0.23
1.2
1.2
—
—
—
0
0
5
38
1.32
0.23
3.8
18.1
10.20
10.42
mmol/l
—
5
33
5
38
1.32
0.23
3.8
18.1
103.60
105.58
mmol/l
—
5
33
16
134
1.20
0.23
1.1
1.1
—
—
—
0
0
7
94
0.74
0.22
1.1
1.2
—
—
—
0
0
40
363
1.12
0.22
1.7
1.6
—
—
—
0
0
5
42
1.19
0.21
1.0
1.0
0.09
1.18
u/ml
—
5
19
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
3.5
—
35.49
—
0
7
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.17
0.21
2.4
2.0
14.56
16.61
%
—
5
43
5
43
1.17
0.21
1.4
1.4
56.58
18.53
u/l
—
5
38
10
80
1.26
0.20
2.4
2.0
2.30
4.89
iu/l
—
5
35
42
385
1.10
0.20
2.8
2.3
133.81
94.94
ug/g
0.44
31
303
38
348
1.10
0.19
1.9
3.1
12.39
7.91
umol/l
0.27
32
311
5
67
0.74
0.17
1.2
1.8
8.56
8.22
kpa
—
5
67
23
206
1.13
0.16
2.8
1.7
2.43
1.47
g/l
0.29
23
191
38
351
1.09
0.16
1.2
1.4
—
—
—
0
0
8
71
1.13
0.16
1.3
1.7
—
—
—
0
0
40
371
1.09
0.16
1.2
1.3
—
—
—
0
0
9
81
1.11
0.15
1.6
1.2
—
—
—
0
0
9
83
1.09
0.15
2.6
1.8
—
—
—
0
0
34
315
1.09
0.14
1.9
1.9
—
—
—
0
0
11
125
0.88
0.10
1.1
1.2
0.95
0.89
g/l
0.16
11
125
21
228
0.92
0.10
1.2
1.3
340.46
119.83
u/ml
—
7
92
87
844
1.04
0.09
1.4
1.5
—
—
—
0
0
10
87
1.15
0.09
1.1
1.1
—
—
—
0
0
6
54
1.11
0.09
1.2
2.9
15.50
28.21
u/ml
—
6
54
13
117
1.12
0.08
3.0
3.3
—
—
—
0
0
11
122
0.90
0.07
1.1
1.1
1.56
1.54
g/l
0.05
11
122
10
89
1.13
0.07
1.3
1.1
—
—
—
0
0
9
103
0.87
0.06
1.7
1.3
—
—
—
0
0
23
217
1.06
0.06
2.8
2.4
6.27
15.48
au/ml
—
6
18
17
182
0.93
0.06
1.5
1.7
—
—
—
0
0
21
201
1.05
0.03
1.3
1.3
—
—
—
0
0
58
589
0.98
0.02
2.1
2.0
—
—
—
0
0
35
342
1.03
0.02
1.6
1.7
—
—
—
0
0
14
146
0.96
0.00
1.6
2.2
0.00
0.02
estimate
—
5
51
12
116
1.04
0.00
1.8
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
57.60
—
0
5
0
9
0.00
-0.00
0.0
1.6
—
66.78
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
0.02
—
0
7
0
8
0.00
-0.00
0.0
1.3
—
2.14
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
47.71
—
0
8
6
66
0.91
-0.00
4.3
4.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.40
—
0
5
10
100
1.00
-0.00
1.2
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
135.34
—
0
7
8
82
0.97
-0.00
1.3
2.1
26.14
24.97
mmol/l
—
8
82
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
31.00
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
6
67
0.89
-0.00
1.2
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
9.80
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint M13_OSTEOMALACIA and mortality.

Females

Parameter HR [95% CI] p-value
M13_OSTEOMALACIA 1.361 [1.13, 1.63] 0.001
Birth year 0.999 [0.99, 1.01] 0.78

During the follow-up period (1.1.1998 — 31.12.2019), 159 out of 1044 females with M13_OSTEOMALACIA died.

Males

Parameter HR [95% CI] p-value
M13_OSTEOMALACIA 1.341 [1.1, 1.63] 0.003
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 827 males with M13_OSTEOMALACIA died.

Mortality risk

Mortality risk for people of age

years, who have M13_OSTEOMALACIA.

N-year risk Females Males
1 0.08% 0.194%
5 0.877% 1.441%
10 2.346% 3.536%
15 4.516% 6.561%
20 7.848% 11.19%

Relationships between endpoints

↥

Index endpoint: M13_OSTEOMALACIA – Osteomalacia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data