Other specified and unspecified disorders of iris and ciliary body

H7_IRISCILIARYNAS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H21.8, H21.9, H22.8* Hospital discharge: ICD-9 — 364[8-9] Cause of death: ICD-10 — H21.8, H21.9, H22.8* Cause of death: ICD-9 — 364[8-9] 2 out of 7 registries used, show all original rules.	168
4. Check minimum number of events None	168
5. Include endpoints None	168
6. Filter based on genotype QC (FinnGen only)	147

Control definitions (FinnGen only)

Control exclude: H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	H7_IRISCILIARYNAS
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H21[8-9]\|H228
HD_ICD_9	364[8-9]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H21[8-9]\|H228
COD_ICD_9	364[8-9]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other specified and unspecified disorders of iris and ciliary body based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	973	537	432
Only index persons	839	470	369
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	54.03	56.06	51.59
Only index persons	53.90	55.91	51.36

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	147	93	54
Unadjusted period prevalence (%)	0.03	0.03	0.02
Median age at first event (years)	53.09	54.20	51.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
156: Matched controls
1560

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H21.9

ICD-10 Finland

Disorder of iris and ciliary body, unspecified

+∞

82.9

H21.8

ICD-10 Finland

Other specified disorders of iris and ciliary body

+∞

80.3

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

199.6

32.0

XCK10

NOMESCO Finland

Photography of fundus of eye

7.4

24.4

S01ED51

ATC

timolol, combinations; ophthalmic

8.2

24.2

H20.1

ICD-10 Finland

Chronic iridocyclitis

+∞

21.3

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

8.7

18.8

Z01.0

ICD-10 Finland

Examination of eyes and vision

4.8

18.7

167

H40.5

ICD-10 Finland

Glaucoma secondary to other eye disorders

37.8

13.8

H20.9

ICD-10 Finland

Iridocyclitis, unspecified

+∞

13.7

CH2S4

NOMESCO Finland

Photography of iris

+∞

13.7

D31.4

ICD-10 Finland

Benign neoplasm: Ciliary body

+∞

13.7

114

Kela drug reimbursment

Glaucoma

5.7

13.4

S01EA05

ATC

brimonidine; ophthalmic

27.0

12.8

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

4.5

11.9

WX140

NOMESCO Finland

Parabulbar anesthesy

6.4

11.8

Z96.1

ICD-10 Finland

Presence of intraocular lens

3.9

11.0

118

L01BA01

ATC

methotrexate; systemic

11.2

10.4

H26.2

ICD-10 Finland

Complicated cataract

18.3

10.1

S01EC01

ATC

acetazolamide; systemic

13.6

9.6

XCW99

NOMESCO Finland

Other investigative procedure of eye

4.3

9.4

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

12.6

9.3

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

12.6

9.3

S01ED01

ATC

timolol; ophthalmic

11.1

9.3

L04AB04

ATC

adalimumab; parenteral

17.6

8.7

3648X

ICD-9 Finland

Disorders of iris and ciliary body, Other disorders of iris and ciliary body

+∞

8.4

XCK00

NOMESCO Finland

Perimetry

5.1

8.1

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

3.6

7.8

CJB10

NOMESCO Finland

Laser discission of secondary cataract

4.3

7.5

L04AX03

ATC

methotrexate; systemic

3.7

7.4

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

4.5

7.3

CD2S4

NOMESCO Finland

Photography of eye

31.6

7.2

L04AA13

ATC

[U] leflunomide

12.9

7.2

CHD15

NOMESCO Finland

Trabeculectomy and iridectomy

41.9

6.8

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

2.4

6.5

454

S01BA04

ATC

prednisolone; ophthalmic

15.1

6.5

CHD50

NOMESCO Finland

Shunt operation on anterior chamber

72.7

6.5

M08.4

ICD-10 Finland

Pauciarticular juvenile arthritis

72.7

6.5

M08.3

ICD-10 Finland

Juvenile polyarthritis (seronegative)

72.7

6.5

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic

2.4

6.4

334

H40.4

ICD-10 Finland

Glaucoma secondary to eye inflammation

+∞

6.3

H21.0

ICD-10 Finland

Hyphaema

+∞

6.3

L04AA17

ATC

[U] adalimumab

+∞

6.3

H21.3

ICD-10 Finland

Cyst of iris, ciliary body and anterior chamber

+∞

6.3

M08.0

ICD-10 Finland

Juvenile rheumatoid arthritis

+∞

6.3

WX100

NOMESCO Finland

Conjunctival surface anesthesia

3.1

6.1

103

XCH00

NOMESCO Finland

Eye pressure measurement

6.3

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42870588) Differential panel, method unspecified - Blood

437

2.38

6.54

9.2

6.0

—

(3021788) Differential panel - Synovial fluid

5.86

4.04

1.5

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.11

4.04

1.4

1.3

—

(3037522) Nuclear Ab [Titer] in Serum

184

2.24

4.00

1.5

1.4

542.22

663.81

titre

0.22

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

363

1.95

3.76

2.4

3.4

1773.38

874.38

ng/l

0.44

311

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

595

1.89

3.73

2.5

2.6

78.87

76.71

nmol/l

0.27

545

(3001122) Ferritin [Mass/volume] in Serum or Plasma

653

1.85

3.44

3.2

3.0

107.77

100.89

ug/l

0.18

613

(3019150) Specific gravity of Urine by Refractometry

307

1.93

3.38

4.4

4.0

1.02

kg/l

0.07

203

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

3.45

3.23

1.2

1.4

—

3.61

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

415

1.82

3.17

2.2

2.6

53.14

66.48

u/l

0.65

387

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.33

2.92

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

373

1.78

2.86

5.3

4.0

0.00

0.01

estimate

0.50

136

(46235355) HIV 1 and 2 tests - Meaningful Use set

306

1.82

2.83

1.7

2.1

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

298

1.83

2.82

1.4

1.9

0.58

1.22

mg/l

1.81

238

(3013826) Glucose [Moles/volume] in Serum or Plasma

101

803

1.73

2.69

4.2

4.7

6.76

6.50

mmol/l

0.44

753

(3013650) Neutrophils [#/volume] in Blood by Automated count

785

1.71

2.64

11.9

9.4

4.16

3.97

e9/l

0.43

687

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

3.21

2.62

1.0

1.2

—

(3015736) pH of Urine

581

1.69

2.62

3.9

3.6

6.22

0.00

321

(3006315) Basophils [#/volume] in Blood

689

1.68

2.57

9.2

6.2

0.04

e9/l

0.27

602

(3002079) Sodium [Moles/time] in 24 hour Urine

7.33

2.56

1.0

1.1

124.80

188.00

mmol/24h

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

169

1.96

2.56

3.1

2.7

6.52

7.94

umol/l

0.24

152

(3035637) Corticotropin [Mass/volume] in Plasma

5.15

2.42

1.0

1.9

17.33

19.47

ng/l

—

(3042936) Bacteria identified in Isolate by Culture

174

1.90

2.35

2.6

1.8

—

(3013115) Eosinophils [#/volume] in Blood

710

1.63

2.32

9.7

6.2

0.20

0.19

e9/l

0.37

632

(3045414) Leukocytes [Presence] in Urine

122

2.04

2.31

2.2

2.1

0.00

estimate

—

(3048689) Calprotectin [Mass/mass] in Stool

191

1.85

2.30

1.9

2.1

73.84

84.25

ug/g

0.19

151

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

644

1.62

2.28

7.0

6.7

1.22

mmol/l

0.02

565

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

531

1.62

2.26

4.6

3.8

0.00

0.06

estimate

1.23

125

(3001604) Monocytes [#/volume] in Blood

686

1.61

2.21

9.4

6.2

0.59

0.55

e9/l

1.15

598

(3008898) HLA-B27 [Presence]

2.49

2.18

1.2

1.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

251

1.74

2.18

1.5

1.7

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

108

901

1.65

2.15

4.1

3.2

56.38

42.35

u/l

0.59

100

862

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.23

2.11

1.6

1.2

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

5.12

2.08

1.2

1.1

—

(3003434) Protein [Mass/volume] in Pleural fluid

5.12

2.08

2.0

1.6

33.02

26.12

g/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

189

1.80

2.08

1.6

—

(3023420) DNA double strand Ab [Units/volume] in Serum

2.34

2.08

1.5

1.4

—

6.83

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

166

1.84

2.05

6.0

5.5

1.00

1.07

mmol/l

0.78

156

(3005719) IgG [Mass/volume] in Serum or Plasma

2.05

2.00

4.6

3.3

10.57

10.10

g/l

0.19

(3019198) Lymphocytes [#/volume] in Blood

707

1.56

1.99

9.5

6.2

2.01

1.86

e9/l

0.93

635

(3032080) INR in Blood by Coagulation assay

593

1.55

1.94

9.8

11.3

1.15

1.18

inr

0.15

487

(3015377) Calcium [Moles/volume] in Serum or Plasma

454

1.56

1.91

4.6

3.0

2.35

2.36

mmol/l

0.48

413

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

2.95

1.89

1.8

1.2

—

(3021960) Folate [Moles/volume] in Serum or Plasma

365

1.59

1.89

1.9

1.7

19.29

20.43

nmol/l

0.22

314

(40761535) Cells panel - Urine sediment

2.11

1.88

4.1

3.6

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

2.17

1.87

1.3

—

49.00

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.44

1.82

1.4

1.2

—

(3025941) Bacteria identified in Stool by Culture

2.14

1.82

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.39

1.75

1.4

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.39

1.75

1.4

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

730

1.51

1.74

4.8

4.0

0.00

0.02

estimate

0.50

142

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

136

1230

1.82

1.74

5.8

5.3

1.74

1.88

mu/l

0.87

130

1152

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

3.93

1.73

1.0

1.3

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

3.93

1.73

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

722

1.50

1.71

4.9

3.9

0.00

10.75

estimate

0.50

151

(3004588) Protein electrophoresis panel - Serum or Plasma

2.13

1.70

3.3

3.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

713

1.50

1.69

4.9

3.9

0.00

estimate

-0.00

147

(40768441) Liver Pathology biopsy report

3.65

1.63

1.8

1.2

—

(3018333) Ribosomal P Ab [Presence] in Serum

3.65

1.63

1.0

1.3

—

(3026493) Urate [Moles/volume] in Serum or Plasma

315

1.55

1.60

3.1

342.56

345.24

umol/l

0.06

270

(40768797) Stomach Pathology biopsy report

179

1.69

1.60

1.1

1.2

—

(40758558) Short blood count panel - Blood

423

1.51

1.60

8.0

6.4

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

3.41

1.53

1.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

3.41

1.53

1.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

3.41

1.53

1.0

1.3

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

2.52

1.50

1.2

1.4

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

3.19

1.45

1.0

1.3

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

2.79

1.45

1.0

1.1

—

(3026008) Bacteria identified in Urine by Culture

404

1.47

1.43

3.1

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

137

1.71

1.38

1.6

2.3

437.59

380.95

nmol/l

0.74

127

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

264

1.53

1.36

1.2

1.3

19.13

27.69

iu/ml

0.49

(3023103) Potassium [Moles/volume] in Serum or Plasma

142

1321

1.84

1.36

21.1

16.6

3.93

3.95

mmol/l

0.27

137

1293

(3021589) Normoblasts [#/volume] in Blood

625

1.42

1.35

12.6

10.5

0.00

e9/l

0.50

513

(3000492) Spirometry study

130

1.71

1.35

1.3

1.5

—

(3044640) Blood type and Crossmatch panel - Blood

420

1.44

1.30

2.2

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

2.83

1.29

1.0

1.2

—

(3022948) Iron [Moles/volume] in Serum or Plasma

215

1.55

1.29

2.2

2.3

14.18

14.29

umol/l

0.02

197

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.11

1.29

2.2

2.4

—

(3019977) pH of Arterial blood

140

1.67

1.29

5.2

7.2

7.43

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.98

1.26

1.4

—

(3023368) Bacteria identified in Blood by Culture

349

1.45

1.25

3.7

3.8

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.11

1.25

1.1

1.3

—

(3009508) Creatinine [Moles/volume] in Urine

460

1.42

1.24

3.3

3.2

8.33

8.27

mmol/l

0.03

394

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

2.68

1.22

1.0

1.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

115

1030

1.44

1.20

4.7

4.4

15.06

14.73

pmol/l

0.67

105

957

(3007164) IgA [Mass/volume] in Serum or Plasma

334

1.44

1.19

1.6

1.5

2.19

2.43

g/l

0.45

191

(40761511) CBC panel - Blood by Automated count

144

1354

1.83

1.19

18.3

12.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

417

1.41

1.18

4.1

4.0

8.76

8.56

mg/mmol

0.01

266

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

186

1.55

1.16

1.7

2.3

—

(3037756) Immunofixation for Serum or Plasma

2.55

1.16

1.2

2.2

—

(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

2.39

1.14

1.9

6.0

—

832.00

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.39

1.14

1.0

1.5

—

(3007566) Smooth muscle Ab [Titer] in Serum

2.05

1.14

1.6

1.2

—

95.00

—

(3022621) pH of Urine by Test strip

113

1.67

1.11

1.6

2.2

5.90

6.12

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

525

1.37

1.11

2.4

2.1

95.00

98.25

pmol/l

0.20

269

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

249

1.47

1.10

3.0

3.7

40.83

308.06

ng/l

1.32

179

(3022145) Colonoscopy Study observation

138

1.60

1.10

1.4

1.3

—

(40767503) Oxygen content in Capillary blood by calculation

2.42

1.10

1.0

3.0

17.54

16.56

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

2.42

1.10

1.0

—

(3004616) Nuclear Ab [Presence] in Serum

2.42

1.10

1.2

1.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

140

1314

1.64

1.06

21.0

14.4

22.27

23.39

mg/l

0.15

123

1052

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

135

1257

1.55

1.06

5.3

4.7

5.99

5.85

mmol/l

0.45

125

1176

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

138

1292

1.59

1.04

6.1

5.5

2.65

2.70

mmol/l

0.29

131

1218

(3014148) Varicella zoster virus Ab [Titer] in Serum

2.31

1.04

1.0

1.1

—

(3013512) EKG study

427

1.37

1.01

3.1

3.2

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.70

1.01

1.3

73.29

297.47

u/ml

0.77

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

2.05

1.01

1.4

1.8

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

1.91

0.99

1.7

1.6

376.20

301.26

mu/l

—

(3012516) Albumin [Mass/volume] in Urine

410

1.36

0.98

3.5

3.3

56.90

48.00

mg/l

0.10

273

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

129

1197

1.45

0.95

7.7

6.1

40.20

38.94

mmol/mol

0.74

120

1134

(3000764) Benzodiazepines [Presence] in Urine

1.73

0.95

1.4

—

(3003740) Influenza virus B Ag [Presence] in Specimen

2.27

0.94

1.2

1.1

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.27

0.94

1.3

1.7

—

(3002523) Influenza virus A Ag [Presence] in Specimen

2.27

0.94

1.2

1.1

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

321

1.38

0.93

4.8

3.8

—

0.40

—

(1761868) Lipid panel - Serum or Plasma

553

0.74

0.93

3.7

3.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.70

0.91

1.2

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

136

1278

1.50

0.90

5.4

4.9

4.54

4.62

mmol/l

0.34

128

1203

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

206

1.44

0.89

1.7

2.4

—

(3028300) Cannabinoids [Presence] in Urine

1.68

0.87

1.5

1.4

—

(3027008) Opiates [Presence] in Urine

1.68

0.87

1.4

—

(3027944) Amphetamines [Presence] in Urine

1.66

0.84

1.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

487

1.30

0.82

3.5

3.7

17.26

36.24

ng/l

1.30

332

(3050129) First trimester maternal screen panel - Serum or Plasma

1.77

0.81

1.2

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

624

1.29

0.80

2.6

2.7

—

estimate

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

160

0.60

0.79

2.5

1.9

3.36

3.35

ratio

—

132

(3016879) Cocaine [Presence] in Urine

1.65

0.77

1.4

—

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

100

1.55

0.76

3.1

2.8

68.44

66.54

ml/min/173m2

—

(3002256) Pathology report gross observation

169

1.42

0.75

1.3

1.2

—

(3019309) Folate [Moles/volume] in Red Blood Cells

188

1.39

0.72

1.6

1463.63

1110.97

nmol/l

0.78

145

(42868678) Cholesterol non HDL [Moles/volume] in Serum or Plasma

117

0.58

0.71

1.9

1.8

2.89

3.44

mmol/l

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

134

1272

1.38

0.67

5.4

4.8

1.47

1.48

mmol/l

0.01

125

1194

(3014051) Protein [Presence] in Urine by Test strip

404

1.27

0.65

2.6

3.2

—

0.25

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

131

1.42

0.62

9.8

8.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.49

0.61

1.6

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

304

1.28

0.61

2.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

128

1212

1.31

0.60

4.5

4.1

1.29

1.24

mmol/l

0.36

116

1130

(3018418) pH of Serum or Plasma

408

1.25

0.60

4.5

4.0

7.39

7.40

0.34

300

(3007853) Bacteria identified in Skin by Aerobe culture

141

1.40

0.60

1.6

1.5

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.60

0.0

1.2

—

5.20

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.50

0.56

1.2

1.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

134

1.39

0.56

1.3

1.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

403

1.24

0.54

3.9

3.4

0.00

0.01

estimate

0.50

123

(3002582) Erythrocytes [#/volume] in Urine

471

1.22

0.53

2.6

3.4

17.79

173.86

e6/l

0.56

347

(40760892) CBC W Ordered Manual Differential panel - Blood

319

1.25

0.53

4.8

5.1

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.50

0.52

3.4

2.9

22.80

24.35

mmol/l

0.75

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

110

1.40

0.51

1.1

1.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.48

0.49

4.2

7.3

23.28

24.84

mmol/l

0.51

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

313

1.24

0.48

1.6

1.7

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.42

0.47

2.8

2.4

5.74

5.60

ug/l

0.02

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.45

0.46

2.1

1.4

44.00

34.08

nmol/l

—

(3000494) Fungus identified in Specimen by Culture

166

1.31

0.46

1.5

1.4

—

(3003694) ABO and Rh group [Type] in Blood

411

1.21

0.45

1.3

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

122

1.35

0.44

1.3

1.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

186

1.28

0.43

1.4

1.8

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.46

0.43

2.0

1.5

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.53

0.41

1.4

1.2

—

(4034850) Laboratory test

1.53

0.41

12.2

10.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.53

0.41

1.0

1.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

1.53

0.41

1.0

1.5

73.23

52.72

ug/l

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.7

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.41

0.0

4.7

—

85.98

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.1

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.41

0.0

1.8

—

(3014037) CD3+CD4+ (T4 helper) cells/cells in Blood

0.00

0.41

0.0

2.5

—

48.83

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.1

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.1

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.41

0.0

2.5

—

1.19

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.41

0.0

2.5

—

3.86

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.5

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.41

0.0

2.5

—

106.76

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.40

0.39

6.2

8.0

1.25

1.37

0.32

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

246

1.22

0.37

1.2

1.3

1.07

4.42

u/ml

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

189

0.77

0.37

2.0

1.6

—

(4094501) Cardiovascular stress test using bicycle ergometer

1.45

0.36

1.2

1.1

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.41

0.35

1.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

197

0.79

0.33

4.2

2.8

0.52

0.67

ug/l

—

116

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.29

0.32

1.3

1.1

—

5.18

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

384

1.17

0.32

1.5

1.4

0.66

2.54

u/ml

1.08

102

(21494755) Public health laboratory ask at order entry panel

131

0.75

0.32

1.1

1.3

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.36

0.31

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

157

1.24

0.31

1.6

1.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

900

1.14

0.31

3.0

3.3

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

1.36

0.31

1.5

0.33

0.38

mg/l

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.31

0.31

1.4

1.6

67.04

51.13

ug/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

214

1.20

0.30

1.2

1.5

—

(3022313) Gas panel - Capillary blood

1.31

0.28

2.0

3.3

—

(4024509) Urine culture

1.26

0.28

2.4

2.0

—

(3019060) Gas panel - Arterial blood

1.30

0.25

3.0

5.3

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.30

0.25

6.7

8.7

92.83

94.97

—

(3028707) Methadone [Presence] in Urine by Screen method

1.33

0.23

1.8

1.6

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

1.26

0.22

1.8

2.7

23.84

25.17

mmol/l

—

(3018095) Leukocytes [#/volume] in Urine

542

1.11

0.22

3.5

4.1

79.45

69.75

e6/l

0.06

366

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

1.23

0.22

1.4

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.24

0.22

1.8

1.4

—

(3007368) IgG [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

32.25

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.21

0.0

1.4

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.0

—

72.50

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.21

0.0

2.7

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.21

0.0

1.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

1.85

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.26

0.20

1.3

1.5

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.20

0.0

1.1

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.23

0.20

1.3

1.5

1.10

1.25

ratio

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.23

0.20

1.3

1.5

0.78

0.95

ratio

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

1.23

0.20

1.5

1.7

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.23

0.20

1.3

1.5

0.97

0.95

ratio

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.18

0.19

3.0

1.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

166

1.16

0.19

1.6

1.7

—

(36660697) Celiac disease serology panel - Serum

138

1.18

0.18

1.4

1.3

—

(3011288) Drugs identified in Urine by Screen method Nominal

1.20

0.18

1.6

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

216

1.13

0.17

1.7

1.9

—

(3030467) Casts [#/volume] in Urine by Automated count

402

1.10

0.16

2.5

3.4

0.51

0.34

e6/l

0.16

281

(1002224) Polysomnography panel

0.76

0.16

1.0

1.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

121

1.17

0.15

2.1

3.1

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.15

0.15

6.3

8.4

0.59

0.63

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.20

0.15

1.6

933.59

894.71

mu/l

0.08

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

554

1.07

0.13

2.0

1.9

1.25

1.37

mmol/l

0.78

473

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

268

0.92

0.10

5.5

4.3

19.82

22.08

0.37

110

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

1.09

0.09

1.2

—

17.20

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.09

0.09

1.2

1.3

—

(3012544) pH of Venous blood

136

1.11

0.09

8.0

3.1

7.37

7.39

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.05

0.08

1.0

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.05

0.08

2.5

2.3

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.83

0.08

2.4

3.8

19.20

2963.25

u/ml

—

(40768443) Skin Pathology biopsy report

0.80

0.08

1.2

—

(40768804) Tissue Pathology biopsy report

532

1.05

0.08

1.9

2.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

100

0.89

0.06

1.2

2.0

—

(40761536) Microorganisms panel - Urine sediment

111

1.09

0.04

7.4

3.9

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

178

0.95

0.02

7.4

6.1

103.53

103.93

mmol/l

0.11

178

(3000991) Gas panel - Venous blood

114

0.96

0.00

6.8

6.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

231

0.99

0.00

2.1

3.2

0.88

2.09

e6/l

—

108

(4035726) Immunohistochemistry procedure

113

0.97

0.00

1.5

1.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

118

1.02

0.00

1.4

2.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

252

0.99

0.00

2.2

3.0

0.95

0.78

e6/l

0.20

129

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

28.51

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.2

—

1.22

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.6

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.6

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.0

1.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.4

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

60.40

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3029396) Erythrocyte agglutination [Presence] in Blood

0.00

-0.00

0.0

2.4

—

(3004446) Plasmodium sp identified in Blood by Light microscopy

0.00

-0.00

0.0

3.0

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

36.37

—

(42529528) Centromere protein B Ab [Units/volume] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.3

—

(3022689) Creatine [Moles/volume] in Urine

0.00

-0.00

0.0

1.2

—

9.18

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.5

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

-0.00

0.0

2.8

—

(3048402) Erythrocytes [#/area] in Urine sediment by Automated count

0.00

-0.00

0.0

1.0

—

0.80

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.3

—

31.37

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

3.6

—

(3033306) Mononuclear cells/Leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

2.2

—

18.82

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

-0.00

0.0

1.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.1

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.94

-0.00

1.2

1.8

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3038769) Chlamydophila pneumoniae IgG Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

32.38

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

132.40

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.6

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

-0.00

0.0

1.0

—

166.43

—

(3020891) Body temperature

0.97

-0.00

11.0

4.8

36.78

36.92

°c

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.6

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.6

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

3.0

—

8.78

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_IRISCILIARYNAS and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_IRISCILIARYNAS	1.164 [0.86, 1.58]	0.327
Birth year	0.998 [0.99, 1.01]	0.68

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 413 females with H7_IRISCILIARYNAS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_IRISCILIARYNAS.

N-year risk	Females	Males
1	0.096%	No data
5	0.77%	No data
10	1.895%	No data
15	3.663%	No data
20	6.734%	No data

Relationships between endpoints

↥

Index endpoint: H7_IRISCILIARYNAS – Other specified and unspecified disorders of iris and ciliary body

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other specified and unspecified disorders of iris and ciliary body

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints