No definition available.
Other congenital malformations of nervous system
Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
373 |
4. Check minimum number of eventsNone |
373 |
5. Include endpointsNone |
373 |
6. Filter based on genotype QC (FinnGen only) |
373 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_NERVOUS_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q0
- Name in latin
- Aliae malformationes congenitae systematis nervosi
Similar endpoints
↥List of similar endpoints to
Other congenital malformations of nervous system
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the nervous system
- Congenital malformations, deformations and chromosomal abnormalities
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3361 | 2035 | 1322 |
| Only index persons | 2889 | 1839 | 1050 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.04 |
| Only index persons | 0.06 | 0.07 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 19.42 | 24.31 | 11.87 |
| Only index persons | 23.03 | 27.09 | 15.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 373 | 300 | 73 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.03 |
| Median age at first event (years) | 32.35 | 32.57 | 31.43 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 330
- Matched controls
- 3300
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q07.0
ICD-10 Finland
Arnold-Chiari syndrome
+∞
323.0
293
*
ABE50
NOMESCO Finland
Occipitocervical decompression
+∞
100.2
91
*
G95.0
ICD-10 Finland
Syringomyelia and syringobulbia
449.5
41.0
40
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
13.3
37.0
67
62
R51.80
ICD-10 Finland
Headache
5.1
35.4
138
405
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
7.3
31.8
83
145
Q07.8
ICD-10 Finland
Other specified congenital malformations of nervous system
+∞
28.5
27
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.5
26.9
76
146
N03AX12
ATC
gabapentin; oral
4.9
21.3
77
194
AA1AD
NOMESCO Finland
CT of head and brain
4.4
21.0
86
246
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
13.5
18.5
32
26
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
16.6
18.3
29
19
R42
ICD-10 Finland
Dizziness and giddiness
3.7
17.5
86
285
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.1
17.4
58
133
R20.2
ICD-10 Finland
Paraesthesia of skin
5.4
16.5
51
107
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
22.3
16.2
23
11
G44.2
ICD-10 Finland
Tension-type headache
3.5
15.2
79
272
Q07.9
ICD-10 Finland
Congenital malformation of nervous system, unspecified
+∞
14.7
14
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
12.2
14.0
25
22
Z01.8
ICD-10 Finland
Other specified special examinations
3.0
13.8
93
382
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.3
12.2
66
231
N03AX16
ATC
pregabalin; oral
3.0
12.0
78
311
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
5.4
11.6
35
71
N06AX21
ATC
duloxetine; oral
3.6
11.6
55
174
M03BX01
ATC
baclofen; systemic
13.3
11.3
19
15
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
3.4
11.0
55
181
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
113.4
10.5
11
*
A02BC02
ATC
pantoprazole; systemic
2.1
10.1
186
1243
R51
ICD-10 Finland
Headache
3.9
9.9
41
116
N02AX02
ATC
tramadol; systemic, rectal
2.2
9.5
117
649
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
9.4
9
*
G47.3
ICD-10 Finland
Sleep apnoea
3.0
9.2
56
212
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
19.2
9.0
13
7
TAB00
NOMESCO Finland
Lumbar puncture
4.3
8.1
29
72
M03BX02
ATC
tizanidine; oral
1.9
7.6
189
1359
A02BC01
ATC
omeprazole; systemic
2.2
7.2
80
418
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.3
7.2
36
119
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
30.7
7.2
9
*
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.8
7.2
48
192
N03AE01
ATC
clonazepam; systemic
4.2
7.2
26
66
N01
ICPC
Headache
2.2
7.1
77
397
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
7.1
144
955
N03AX11
ATC
topiramate; oral
4.9
6.8
21
45
M54.4
ICD-10 Finland
Lumbago with sciatica
2.4
6.8
58
266
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
6.7
80
429
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
6.6
48
202
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
6.6
107
652
A01
ICPC
Pain general/multiple sites
3.2
6.5
33
111
L01
ICPC
Neck symptom/complaint
2.4
6.4
57
266
XKD00
NOMESCO Finland
Uroflowmetry
3.5
6.3
28
85
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
6.3
6
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
6.1
81
453
N06AX16
ATC
venlafaxine; oral
2.2
6.1
62
309
M54.5
ICD-10 Finland
Low back pain
1.9
6.1
109
683
SPAT1301
SPAT
No procedures
1.9
6.0
110
691
N02BE01
ATC
paracetamol; systemic, rectal
1.9
6.0
257
2138
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
215
1192
2.90
22.41
9.2
6.2
1.21
1.22
mmol/l
1.08
190
1031
200
1091
2.80
21.12
8.9
5.9
1.22
1.22
mmol/l
0.77
184
1017
23
26
9.36
18.73
2.8
1.4
—
—
—
0
0
18
16
11.77
17.22
1.1
1.6
—
—
—
0
0
128
635
2.55
15.31
2.2
2.1
238.93
269.92
u/l
0.07
121
610
15
12
12.98
15.23
1.4
1.7
—
—
—
0
0
35
79
4.79
14.82
2.2
2.1
78.77
6.51
e6/l
1.02
26
61
35
79
4.79
14.82
2.2
2.2
142.41
219.18
e6/l
0.26
27
65
234
1544
2.38
14.47
6.5
4.3
5.98
6.28
mmol/l
2.19
223
1381
55
183
3.35
13.65
7.3
7.8
0.99
0.90
mmol/l
0.06
38
139
280
2028
2.53
13.62
6.2
6.4
73.56
78.36
u/l
1.20
267
1899
352
2917
4.67
12.64
16.0
9.9
3.93
3.91
mmol/l
0.72
347
2813
351
2917
4.45
12.23
16.3
9.8
139.60
139.56
mmol/l
0.14
346
2824
315
2507
2.65
10.96
5.1
4.1
14.40
14.37
pmol/l
0.09
296
2318
156
947
2.11
10.87
4.2
4.8
38.02
37.17
g/l
1.53
142
897
146
866
2.13
10.80
2.1
1.7
97.93
98.49
pmol/l
0.05
91
453
277
2145
2.13
9.30
4.4
3.7
8.47
8.92
mm/h
0.29
263
2003
83
414
2.29
9.28
1.4
1.5
123881043.70
22554785.35
pmol/l
0.37
67
368
339
2871
2.98
9.09
5.9
4.7
1.64
1.80
mu/l
2.39
324
2698
123
728
2.03
8.83
3.3
2.8
17.48
23.99
ng/l
0.37
58
332
188
1292
1.92
8.67
5.2
5.7
10.06
11.09
umol/l
0.30
175
1211
357
3172
3.93
7.63
10.1
8.3
23.23
24.76
u/l
1.12
352
3066
49
212
2.51
7.45
13.6
7.8
24.42
24.88
mmol/l
0.42
49
212
114
697
1.92
7.23
2.4
2.1
2.92
2.76
mg/l
0.33
96
596
62
308
2.21
6.90
1.8
2.1
385.83
383.39
nmol/l
0.03
53
288
121
768
1.85
6.77
3.1
2.4
51.60
56.55
u/l
0.98
110
715
20
54
3.86
6.73
2.2
1.9
864.92
189.34
ug/l
0.60
13
46
172
1217
1.77
6.68
2.9
2.5
72.79
71.84
nmol/l
0.17
160
1119
85
483
1.98
6.63
1.5
1.3
19.44
20.65
nmol/l
0.33
74
417
46
208
2.38
6.35
11.5
5.2
1.34
1.20
mmol/l
0.12
31
146
284
2344
1.89
6.35
4.4
4.1
36.59
37.47
mmol/mol
1.04
264
2219
13
27
4.95
6.02
1.1
1.1
—
—
—
0
0
228
1779
1.72
6.00
8.6
8.6
3.79
3.96
e9/l
0.54
204
1539
135
913
1.75
5.98
4.1
3.1
—
—
—
0
0
73
408
1.98
5.92
3.2
3.5
475.31
671.67
ng/l
0.51
57
327
62
328
2.07
5.85
1.7
1.5
1049.21
1136.78
nmol/l
0.37
51
257
125
832
1.76
5.83
2.0
2.8
2.35
2.35
mmol/l
0.16
112
751
99
615
1.83
5.82
1.7
2.1
0.80
0.97
mg/l
0.36
68
433
47
223
2.27
5.82
1.1
1.2
—
29.87
—
0
9
15
38
4.07
5.49
1.1
1.1
—
—
—
0
0
306
2629
1.91
5.49
3.9
3.3
5.58
5.58
mmol/l
0.00
286
2449
108
702
1.76
5.42
2.6
2.0
—
—
—
0
0
49
245
2.15
5.34
5.7
5.0
—
—
—
0
0
14
36
4.00
5.03
1.0
1.1
—
—
—
0
0
345
3121
2.40
4.99
15.8
10.1
15.99
19.80
mg/l
2.00
298
2338
210
1678
1.58
4.43
3.5
2.9
69.21
64.60
ug/l
0.18
202
1572
133
956
1.61
4.42
3.6
3.2
26.78
28.41
u/l
0.51
125
913
48
261
1.96
4.19
8.8
5.2
1.93
1.59
mmol/l
0.35
39
195
193
1529
1.54
4.12
6.6
5.7
53.45
55.18
%
1.22
182
1446
49
272
1.92
4.03
1.4
1.7
21.22
19.64
iu/l
0.11
41
226
61
364
1.81
4.01
1.9
2.2
2.40
2.41
mmol/l
0.42
54
316
246
2069
1.56
3.91
3.7
2.9
33.27
33.49
u/l
0.02
235
1979
96
657
1.62
3.83
4.5
3.1
1.02
1.02
kg/l
0.37
15
89
112
800
1.57
3.73
4.9
3.3
0.00
0.00
estimate
0.50
43
314
41
220
1.97
3.72
2.1
3.0
0.22
0.23
g/l
0.58
35
214
83
554
1.64
3.65
1.3
1.3
16.83
25.21
iu/ml
0.88
26
159
192
1547
1.50
3.62
6.8
5.9
31.93
30.90
%
0.66
178
1462
53
314
1.80
3.57
1.3
1.3
117.34
155.95
iu/ml
0.46
19
129
179
1425
1.49
3.56
4.3
3.8
—
—
—
0
0
66
426
1.67
3.29
3.3
2.7
1.11
0.90
e6/l
0.27
40
229
147
1142
1.47
3.22
4.9
3.1
—
—
—
0
0
25
118
2.20
3.18
1.6
2.9
81.10
121.43
ng/l
0.50
20
107
15
56
2.75
3.09
2.3
1.6
—
—
—
0
0
183
1493
1.44
3.06
4.7
3.1
0.00
0.00
estimate
0.00
42
312
101
736
1.51
3.00
4.3
3.0
0.34
0.35
e6/l
0.01
80
546
130
998
1.46
2.98
1.4
1.4
0.86
2.06
u/ml
1.27
36
248
291
2605
1.53
2.93
10.7
8.3
99.78
95.90
ml/min/173m2
2.56
251
2030
81
568
1.54
2.86
1.9
2.8
299.56
4193.28
umol/l
1.82
71
503
30
159
1.96
2.85
3.6
4.1
1.23
1.23
mmol/l
0.36
23
136
43
261
1.73
2.69
2.1
2.4
24.34
32.10
u/l
1.22
38
214
55
357
1.63
2.68
1.9
1.8
—
—
—
0
0
14
55
2.61
2.64
2.1
1.3
—
—
—
0
0
61
408
1.59
2.64
3.6
2.8
4.91
3.38
e6/l
0.53
36
212
7
15
4.73
2.61
1.0
1.2
—
—
—
0
0
183
1524
1.39
2.58
4.9
3.2
0.00
0.00
estimate
0.00
44
304
43
266
1.70
2.52
1.4
1.2
137.59
260.12
u/ml
0.59
37
242
9
26
3.52
2.49
1.8
4.2
—
—
—
0
0
180
1503
1.38
2.46
6.4
4.4
0.00
0.00
estimate
0.50
39
318
299
2726
1.49
2.43
3.9
3.5
2.80
2.82
mmol/l
0.13
279
2566
8
23
3.53
2.28
6.9
4.9
1.66
1.56
ug/l
—
8
23
138
1117
1.37
2.24
2.1
1.7
—
—
—
0
0
5
9
5.61
2.22
2.6
2.8
55.00
55.11
nmol/l
—
5
9
38
241
1.64
2.05
1.6
1.6
—
—
—
0
0
38
241
1.64
2.05
1.6
1.7
—
—
—
0
0
23
126
1.88
2.03
1.8
1.4
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
21
3.38
1.97
1.0
1.1
—
—
—
0
0
8
27
3.00
1.94
1.6
1.5
512.75
468.50
pmol/l
—
8
20
60
429
1.48
1.93
2.2
1.6
1.31
1.32
%
0.04
54
389
302
2801
1.41
1.85
4.0
4.0
—
—
—
0
0
293
2708
1.38
1.80
3.6
3.3
4.64
4.68
mmol/l
0.28
277
2565
6
18
3.37
1.75
2.0
2.8
1.37
2.61
nmol/l
—
6
18
13
61
2.17
1.73
1.2
1.6
—
—
—
0
0
291
2694
1.36
1.71
3.5
3.3
1.49
1.49
mmol/l
0.07
272
2540
280
2578
1.35
1.70
3.3
3.0
1.18
1.19
mmol/l
0.12
262
2431
72
548
1.39
1.66
1.3
1.3
4.73
9.75
u/ml
0.73
27
216
5
14
3.60
1.62
1.8
1.2
—
—
—
0
0
18
304
0.57
1.53
1.6
1.5
—
—
—
0
0
51
372
1.43
1.50
2.5
2.4
4426.74
3336.37
u/l
0.12
14
158
68
522
1.37
1.50
1.7
1.8
—
—
—
0
0
327
3105
1.43
1.48
15.6
11.1
40.31
40.13
%
0.24
254
2614
5
16
3.15
1.44
1.0
1.1
1562.80
1631.06
miu/ml
—
5
16
15
81
1.89
1.42
1.8
1.7
89.00
116.05
u/ml
—
7
14
29
191
1.56
1.39
1.3
1.8
8.09
9.51
u/l
0.28
21
152
24
358
0.65
1.25
1.4
1.5
—
—
—
0
0
8
36
2.25
1.25
2.1
1.5
—
—
—
0
0
18
108
1.70
1.24
1.2
1.5
—
—
—
0
0
5
19
2.65
1.22
1.2
1.4
75.20
75.84
%
—
5
19
5
19
2.65
1.22
1.2
1.4
683.00
468.27
mu/l
—
5
19
37
267
1.43
1.18
1.5
1.7
—
—
—
0
0
18
110
1.67
1.17
1.7
2.1
—
—
—
0
0
20
126
1.62
1.17
1.3
1.4
—
—
—
0
0
52
400
1.35
1.15
3.3
2.9
26.58
354.86
ng/l
3.31
26
218
11
58
1.92
1.13
12.2
4.0
1.75
1.43
%
0.53
11
53
24
161
1.52
1.10
1.9
1.5
—
—
—
0
0
18
277
0.63
1.10
1.4
1.4
—
—
—
0
0
79
650
1.27
1.08
2.0
1.9
—
—
—
0
0
7
32
2.21
1.08
2.4
1.4
—
—
—
0
0
17
105
1.65
1.08
1.8
2.1
9.61
6.25
iu/l
—
7
36
14
82
1.73
1.06
1.1
1.1
—
—
—
0
0
7
33
2.14
1.06
1.7
1.4
—
—
—
0
0
5
22
2.29
1.03
1.4
1.7
0.77
1.01
g/l
—
5
22
7
35
2.02
1.00
2.0
1.4
—
—
—
0
0
7
35
2.02
1.00
2.0
1.4
—
—
—
0
0
41
531
0.74
1.00
1.5
1.5
—
—
—
0
0
0
29
0.00
0.98
0.0
1.4
—
—
—
0
0
7
36
1.96
0.97
2.0
1.4
—
—
—
0
0
7
36
1.96
0.97
2.0
1.4
—
—
—
0
0
7
36
1.96
0.97
2.0
1.4
—
—
—
0
0
7
36
1.96
0.97
2.0
1.4
—
—
—
0
0
19
278
0.67
0.94
1.4
1.4
—
—
—
0
0
9
52
1.75
0.93
1.2
1.7
38.86
38.95
g/l
—
9
47
19
277
0.67
0.92
1.4
1.4
—
—
—
0
0
19
277
0.67
0.92
1.4
1.4
—
—
—
0
0
23
160
1.47
0.91
5.1
3.9
21.38
21.08
%
—
10
58
11
63
1.77
0.91
1.5
1.3
—
—
—
0
0
11
63
1.77
0.91
1.5
1.3
—
—
—
0
0
11
63
1.77
0.91
1.6
1.3
—
—
—
0
0
6
29
2.09
0.89
1.2
1.1
—
—
—
0
0
10
56
1.81
0.88
1.2
1.7
11.49
10.49
g/l
—
10
51
18
120
1.53
0.87
3.8
1.9
0.13
0.10
e6/l
0.13
18
114
8
44
1.84
0.86
1.5
2.1
—
—
—
0
0
6
31
1.95
0.84
1.5
1.2
—
—
—
0
0
19
130
1.49
0.82
1.3
1.2
—
—
—
0
0
18
258
0.68
0.82
1.4
1.6
—
—
—
0
0
8
48
1.68
0.79
2.0
1.7
12.86
13.20
%
—
8
48
0
27
0.00
0.77
0.0
1.7
—
—
—
0
0
16
107
1.52
0.77
1.8
1.6
—
—
—
0
0
6
34
1.78
0.76
1.8
1.4
—
—
—
0
0
0
28
0.00
0.76
0.0
1.4
—
—
—
0
0
35
272
1.32
0.76
3.1
3.3
32.18
31.41
%
0.18
28
188
9
54
1.68
0.75
3.2
1.6
—
—
—
0
0
5
24
2.10
0.75
1.0
1.0
—
—
—
0
0
5
25
2.01
0.73
1.6
2.7
—
—
—
0
0
5
27
1.86
0.68
1.0
1.0
—
0.10
u/ml
—
0
8
5
27
1.86
0.68
1.4
1.6
—
—
—
0
0
15
102
1.49
0.68
2.0
2.1
—
—
—
0
0
15
104
1.46
0.63
1.8
1.7
242.67
214.51
u/ml
—
9
60
58
493
1.21
0.62
4.2
4.3
4.25
14.48
mg/mmol
1.93
36
318
14
96
1.48
0.62
1.4
1.9
—
—
—
0
0
34
272
1.28
0.62
1.1
1.1
—
—
—
0
0
6
36
1.68
0.57
1.8
1.1
—
—
—
0
0
6
37
1.63
0.56
2.0
1.3
170.67
209.97
pmol/l
—
6
37
29
232
1.27
0.54
3.7
3.7
4.58
4.82
pmol/l
0.59
29
209
11
75
1.48
0.51
1.6
2.0
—
—
—
0
0
11
156
0.70
0.51
1.5
2.1
—
—
—
0
0
10
67
1.51
0.50
1.0
1.2
—
—
—
0
0
26
210
1.26
0.46
2.8
2.4
—
—
—
0
0
13
95
1.38
0.44
1.6
1.7
0.03
0.03
iu/ml
—
8
12
5
33
1.52
0.41
2.8
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
3.6
—
—
—
0
0
8
60
1.34
0.40
3.3
4.1
55.88
56.05
%
—
8
60
0
18
0.00
0.40
0.0
1.0
—
100.70
—
0
10
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
18
0.00
0.40
0.0
1.0
—
134.78
—
0
18
14
106
1.33
0.39
14.9
11.2
1.16
1.14
mg/l
0.08
14
101
18
225
0.79
0.39
2.2
1.7
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
94.82
—
0
11
5
37
1.36
0.37
1.0
1.5
—
—
—
0
0
10
72
1.40
0.37
3.5
1.6
—
—
—
0
0
16
201
0.79
0.36
1.6
1.5
—
—
—
0
0
6
41
1.47
0.36
1.0
3.0
—
—
—
0
0
15
117
1.29
0.35
1.3
1.2
—
—
—
0
0
6
42
1.44
0.35
1.3
1.5
—
—
—
0
0
10
73
1.38
0.35
2.7
1.6
—
—
—
0
0
73
670
1.11
0.31
1.5
1.6
1.31
1.36
mmol/l
0.20
65
591
7
56
1.25
0.29
3.4
1.7
0.45
6.65
ug/l
—
7
51
9
72
1.26
0.26
1.0
1.1
—
—
—
0
0
15
123
1.23
0.25
1.8
1.3
—
—
—
0
0
5
38
1.32
0.23
1.4
1.5
—
—
—
0
0
14
116
1.21
0.22
1.4
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
26.22
—
0
10
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
3.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
5
43
1.16
0.21
1.4
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
2.79
—
0
13
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
6
48
1.25
0.20
1.5
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
4.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
0.29
—
0
7
0
14
0.00
0.20
0.0
4.3
—
—
—
0
0
105
1002
1.07
0.20
2.7
2.4
—
—
—
0
0
8
70
1.15
0.16
1.4
1.2
—
—
—
0
0
12
140
0.85
0.15
1.0
1.1
—
6.15
—
0
18
17
190
0.89
0.13
2.1
2.2
16.25
48.17
u/ml
1.54
17
180
96
926
1.05
0.13
2.7
2.2
—
—
—
0
0
22
201
1.10
0.11
1.3
1.4
247.67
258.35
miu/ml
0.05
12
100
19
173
1.10
0.10
4.4
2.5
55.17
82.65
ml/min/173m2
—
6
65
5
44
1.14
0.10
2.8
1.7
—
—
—
0
0
7
65
1.08
0.08
1.4
1.6
—
—
—
0
0
20
186
1.08
0.07
1.4
1.4
—
—
—
0
0
85
831
1.03
0.06
1.8
1.4
—
—
—
0
0
16
149
1.08
0.05
1.4
1.5
—
—
—
0
0
14
149
0.94
0.03
1.5
1.7
—
—
—
0
0
12
128
0.94
0.02
1.8
1.5
—
—
—
0
0
15
145
1.04
0.00
1.3
1.4
—
—
—
0
0
28
275
1.02
0.00
1.5
1.3
—
—
—
0
0
16
164
0.97
0.00
1.6
1.7
2.37
2.81
mg/l
—
9
110
35
354
0.99
0.00
1.7
1.4
—
—
—
0
0
5
50
1.00
0.00
1.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
5
59
0.85
0.00
1.0
1.1
—
—
—
0
0
6
63
0.95
0.00
1.0
2.3
1.48
0.86
nmol/l
—
6
57
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
9.44
—
0
6
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM | 1.466 [1.11, 1.94] | 0.008 |
| Birth year | 1.002 [0.99, 1.01] | 0.727 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 1703 females with Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM | 2.062 [1.43, 2.98] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 1152 males with Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | 0.435% |
| 5 | 1.029% | 2.466% |
| 10 | 2.689% | 5.886% |
| 15 | 4.951% | 11.231% |
| 20 | 8.946% | 18.364% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM – Other congenital malformations of nervous system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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