Abuse of non-dependence-producing substances

F5_ABUNONDEP

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — F55 Cause of death: ICD-10 — F55 2 out of 7 registries used, show all original rules.	60
4. Check minimum number of events None	60
5. Include endpoints None	60
6. Filter based on genotype QC (FinnGen only)	50

Control definitions (FinnGen only)

Control exclude: F5_BEHAVE

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: F50-F59
Name in latin: Abusus substantiarum dependentiam non producentium

NAME	F5_ABUNONDEP
CONTROL_EXCLUDE	F5_BEHAVE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F55
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F55
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Abuse of non-dependence-producing substances based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	749	254	484
Only index persons	503	166	337
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	45.87	47.41	44.73
Only index persons	38.96	36.57	40.14

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	50	23	27
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	45.18	42.60	47.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
54: Matched controls
540

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

F55

ICD-10 Finland

Abuse of non-dependence-producing substances

+∞

77.3

F32.9

ICD-10 Finland

Depressive episode, unspecified

19.7

27.6

T36

ICD-10 Finland

Poisoning by systemic antibiotics

44.8

20.7

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

52.1

20.6

N06AB04

ATC

citalopram; systemic

11.8

18.9

N06AX16

ATC

venlafaxine; oral

11.9

18.7

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

22.9

18.5

F51.0

ICD-10 Finland

Nonorganic insomnia

+∞

16.5

N05AH04

ATC

quetiapine; oral

8.9

14.8

N06AX11

ATC

mirtazapine; oral

8.7

14.0

108

N05BA01

ATC

diazepam; systemic, rectal

8.4

12.3

N05BA02

ATC

chlordiazepoxide; systemic

+∞

11.9

N05CF01

ATC

zopiclone; oral

6.9

11.6

N05AA02

ATC

levomepromazine; systemic

25.2

11.0

N05BA04

ATC

oxazepam; oral

6.6

10.9

F33.9

ICD-10 Finland

Recurrent depressive disorder, unspecified

20.1

10.2

N06AB06

ATC

sertraline; oral

9.7

9.8

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

11.7

9.6

X44

ICD-10 Finland

Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances

45.0

9.4

AA1AD

NOMESCO Finland

CT of head and brain

5.4

8.6

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

12.5

8.5

N05AH03

ATC

olanzapine; systemic

12.5

8.5

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

5.9

8.4

F10.25

ICD-10 Finland

Alcohol dependence continuous use

40.0

8.4

F10.21

ICD-10 Finland

Alcohol dependence currently abstinent, but staying in restrictive environment

52.9

8.0

F10.26

ICD-10 Finland

Alcohol dependence periodic alcoholism

52.9

8.0

F60.30

ICD-10 Finland

Emotionally unstable personality disorder, impulsive

52.9

8.0

N07BB01

ATC

disulfiram; oral

13.8

7.8

F10.00

ICD-10 Finland

Alcohol-related acute intoxication uncomplicated

24.0

7.4

F10.09

ICD-10 Finland

Alcohol intoxication UNS

24.0

7.4

R11

ICD-10 Finland

Nausea and vomiting

9.4

7.3

R56.8

ICD-10 Finland

Other and unspecified convulsions

11.8

7.3

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

7.5

7.1

N05AF03

ATC

chlorprothixene; systemic

26.4

6.9

A06AD11

ATC

lactulose; oral

7.2

6.9

N05CD07

ATC

temazepam; oral

8.2

6.8

N06AA06

ATC

trimipramine; systemic

78.8

6.6

N05BE01

ATC

buspirone; oral

30.7

6.4

Z72.2

ICD-10 Finland

Drug use

+∞

6.4

P15

ICPC

Chronic alcohol abuse

11.2

6.1

R55

ICD-10 Finland

Syncope and collapse

8.2

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3011288) Drugs identified in Urine by Screen method Nominal

11.26

8.95

17.7

2.1

—

(3028300) Cannabinoids [Presence] in Urine

6.42

8.62

17.5

1.8

—

(3027944) Amphetamines [Presence] in Urine

6.07

7.83

18.9

1.8

—

(3027008) Opiates [Presence] in Urine

5.90

7.60

6.0

1.8

—

(3028707) Methadone [Presence] in Urine by Screen method

9.52

6.96

16.5

2.2

—

(3000764) Benzodiazepines [Presence] in Urine

6.21

6.19

18.5

1.9

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

6.43

6.06

19.3

1.9

—

(3016879) Cocaine [Presence] in Urine

5.70

5.53

19.4

1.8

—

(3019977) pH of Arterial blood

4.41

5.43

11.2

8.4

7.41

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

5.47

4.01

9.0

5.9

23.72

25.13

mmol/l

0.39

(3023183) Ammonium ion [Moles/volume] in Plasma

7.60

3.82

3.8

2.3

32.38

39.00

umol/l

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

3.20

3.59

3.6

2.4

22.92

127.73

ng/l

0.79

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

5.17

3.28

4.0

3.1

2.73

1.46

—

(3000991) Gas panel - Venous blood

3.87

3.19

11.4

7.4

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

8.25

3.14

1.5

1.4

—

(3032080) INR in Blood by Coagulation assay

198

2.71

3.12

19.0

9.5

1.30

1.16

inr

0.68

163

(3026008) Bacteria identified in Urine by Culture

115

2.74

3.11

4.3

3.1

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

160

2.56

2.85

6.0

3.7

30.74

31.12

u/l

0.03

153

(3004119) Hemoglobin [Mass/volume] in Venous blood

4.28

2.82

4.9

2.9

132.89

122.17

g/l

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

9.01

2.80

43.6

1.0

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

4.50

2.69

3.0

2.0

23.49

24.49

mmol/l

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

257

2.62

2.64

10.8

4.9

6.48

6.70

mmol/l

0.24

242

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

3.37

2.60

4.0

3.2

4.67

5.10

kpa

0.81

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

101

2.56

2.59

1.9

2.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

5.47

2.47

1.7

1.5

—

(3018405) Lactate [Moles/volume] in Arterial blood

4.56

2.45

3.0

7.8

1.43

1.16

mmol/l

—

(3019060) Gas panel - Arterial blood

3.64

2.44

9.1

4.0

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

3.51

2.35

11.3

9.1

0.76

0.72

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

5.04

2.34

2.0

1.4

—

(3026782) Osmolality of Urine

2.53

2.33

3.9

2.8

492.50

537.86

mosm/kgh2o

0.30

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.73

2.28

1.6

1.5

—

(3014007) Fractional oxyhemoglobin in Arterial blood

3.39

2.27

11.0

9.1

92.64

93.71

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.95

2.24

1.5

1.7

—

(3012544) pH of Venous blood

2.95

2.24

3.8

2.5

7.38

7.39

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.65

2.24

10.6

7.9

103.50

105.02

mmol/l

0.44

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

3.27

2.19

11.3

8.8

2.40

1.54

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

3.86

2.13

3.7

3.1

0.63

0.71

—

(3022313) Gas panel - Capillary blood

3.43

2.11

3.9

3.5

—

(3043409) Potassium [Moles/volume] in Arterial blood

4.08

1.99

3.2

4.0

3.78

3.93

mmol/l

—

(3044640) Blood type and Crossmatch panel - Blood

147

2.14

1.92

2.4

2.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.19

1.79

1.6

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.25

1.79

2.4

1.9

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

4.12

1.75

2.0

2.2

—

(3019150) Specific gravity of Urine by Refractometry

110

2.12

1.72

8.4

4.0

1.01

1.02

kg/l

1.43

(1761868) Lipid panel - Serum or Plasma

202

0.43

1.72

2.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.64

1.54

3.6

3.7

—

(3015736) pH of Urine

178

1.89

1.44

7.0

3.8

6.28

6.09

0.38

104

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.20

1.41

2.2

1.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.43

1.31

2.0

1.5

—

(3026361) Erythrocytes [#/volume] in Blood

503

0.42

1.28

42.8

21.6

4.53

4.60

e12/l

0.33

494

(3010813) Leukocytes [#/volume] in Blood

503

0.42

1.28

42.9

21.7

7.30

6.72

e9/l

1.14

494

(3035941) MCH [Entitic mass]

503

0.42

1.28

42.6

21.5

29.95

30.18

0.22

496

(3024731) MCV [Entitic mean volume] in Red Blood Cells

503

0.42

1.28

42.7

21.5

90.06

90.39

0.12

496

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

503

0.42

1.28

43.7

21.9

40.06

41.39

1.21

496

(3000963) Hemoglobin [Mass/volume] in Blood

503

0.42

1.28

43.1

21.7

132.70

138.17

g/l

1.44

496

(42870588) Differential panel, method unspecified - Blood

139

1.84

1.26

8.7

5.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

252

1.80

1.22

9.5

10.9

5.20

4.24

e9/l

0.77

215

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

1.20

0.0

1.7

—

801.95

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.17

1.18

2.0

2.5

—

(3013115) Eosinophils [#/volume] in Blood

225

1.75

1.16

9.9

7.2

0.14

0.19

e9/l

1.21

196

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

332

0.58

1.11

4.7

3.1

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.40

1.05

7.4

3.1

27.46

23.95

mmol/l

—

(40768797) Stomach Pathology biopsy report

2.00

1.05

1.1

1.3

—

(3001604) Monocytes [#/volume] in Blood

220

1.69

1.05

7.6

6.8

0.63

0.58

e9/l

0.40

190

(3006315) Basophils [#/volume] in Blood

220

1.69

1.05

7.7

6.8

0.04

e9/l

0.06

190

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.15

1.04

1.9

2.4

—

(40761511) CBC panel - Blood by Automated count

478

0.51

1.03

25.3

12.8

—

(3035350) Ketones [Presence] in Urine by Test strip

231

1.67

1.01

6.6

3.8

0.00

estimate

—

(3019069) Monocytes/Leukocytes in Blood

203

1.66

0.99

12.2

6.4

7.34

8.42

1.11

193

(3022145) Colonoscopy Study observation

2.01

0.92

1.3

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

169

1.63

0.91

7.8

3.9

15.24

32.12

ng/l

2.26

108

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.93

0.91

2.3

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.83

0.91

1.8

1.6

—

(3023368) Bacteria identified in Blood by Culture

125

1.66

0.88

6.3

4.9

—

(3018095) Leukocytes [#/volume] in Urine

171

1.60

0.86

6.7

3.5

47.92

42.22

e6/l

0.05

119

(3013512) EKG study

126

1.64

0.85

6.7

3.6

—

(3021601) Nitrite [Presence] in Urine by Test strip

230

1.56

0.81

6.9

3.7

0.00

estimate

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.81

0.0

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

174

1.56

0.79

7.9

3.9

0.00

estimate

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.29

0.78

2.8

1.9

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.29

0.78

2.8

2.3

—

(3009261) Glucose [Presence] in Urine by Test strip

232

1.54

0.77

6.9

3.8

0.00

estimate

—

(3029937) Albumin [Presence] in Urine by Test strip

129

1.59

0.77

8.2

3.4

0.00

estimate

—

(3018418) pH of Serum or Plasma

129

1.59

0.77

5.1

4.1

7.39

7.40

0.07

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.10

0.75

6.4

3.6

69.84

51.27

—

(36660697) Celiac disease serology panel - Serum

1.86

0.75

1.3

—

(3002582) Erythrocytes [#/volume] in Urine

148

1.56

0.74

4.7

3.0

78.02

32.74

e6/l

0.28

117

(46235355) HIV 1 and 2 tests - Meaningful Use set

122

1.57

0.71

3.3

2.0

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

347

1.59

0.71

7.9

3.3

64.71

49.37

u/l

0.50

333

(3025941) Bacteria identified in Stool by Culture

1.86

0.68

2.6

1.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

287

1.50

0.67

6.2

4.1

—

(3042936) Bacteria identified in Isolate by Culture

1.66

0.65

1.4

2.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

209

1.47

0.64

2.4

2.7

—

estimate

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

0.00

0.62

0.0

1.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.62

0.0

2.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.62

0.0

1.7

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.61

0.0

1.7

—

1.09

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.61

0.0

1.7

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.61

0.0

1.7

—

0.90

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.61

0.0

1.7

—

0.95

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.61

0.0

1.7

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.61

0.0

1.7

—

62.36

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.57

0.58

1.4

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

185

1.42

0.55

3.5

2.1

98.34

94.30

pmol/l

0.16

(3030467) Casts [#/volume] in Urine by Automated count

129

1.46

0.55

3.4

2.9

0.36

0.51

e6/l

0.19

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.49

0.48

4.7

7.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

484

0.67

0.45

34.7

17.5

71.26

76.97

umol/l

1.30

476

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.62

0.43

1.4

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

107

1.42

0.43

3.1

6.3

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

0.42

0.0

1.1

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.42

0.0

1.8

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.41

0.0

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.1

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

0.67

0.36

1.7

3.1

2.47

2.46

mmol/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.41

0.36

1.0

2.4

—

(3000494) Fungus identified in Specimen by Culture

1.37

0.32

1.1

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

103

1.35

0.32

1.8

1.7

—

(36304419) Bacteria [Presence] in Urine

122

1.32

0.31

3.5

2.8

—

estimate

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.67

0.28

2.0

1.3

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

1.20

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.6

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.2

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.6

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.21

0.0

4.0

—

1.42

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

2.0

—

11.77

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.21

0.0

1.6

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

2.3

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

51.10

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.20

0.0

1.1

—

(3003694) ABO and Rh group [Type] in Blood

151

0.82

0.19

1.2

1.4

—

(40758558) Short blood count panel - Blood

130

1.21

0.18

7.5

6.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.73

0.18

1.4

1.9

—

(3048689) Calprotectin [Mass/mass] in Stool

0.70

0.18

8.0

1.5

208.62

76.23

ug/g

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.78

0.15

2.6

1.6

—

(3037522) Nuclear Ab [Titer] in Serum

1.06

0.09

1.2

1.4

—

524.44

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.10

0.08

3.1

2.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.10

0.07

3.1

2.1

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

451

1.13

0.07

35.7

16.4

3.93

3.96

mmol/l

0.24

443

(3019550) Sodium [Moles/volume] in Serum or Plasma

451

1.13

0.07

36.1

16.4

138.24

139.82

mmol/l

2.28

442

(40768804) Tissue Pathology biopsy report

167

0.94

0.01

1.5

2.0

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

147

1.03

0.00

2.5

3.1

2.34

2.37

mmol/l

0.38

136

(3021589) Normoblasts [#/volume] in Blood

198

1.02

0.00

18.0

11.5

0.00

e9/l

-0.00

158

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(4146454) Self-monitoring of blood glucose

0.00

0.0

4.3

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

2.6

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.9

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.3

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

2.6

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(1616796) Gas panel - Central venous blood

0.00

0.0

2.3

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

9.4

—

631.00

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.7

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

2.4

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.2

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.7

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

1.6

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.0

—

1.44

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

-0.00

0.0

1.6

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

2.4

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

-0.00

0.0

1.8

—

9.58

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.7

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

458

1.03

-0.00

29.1

14.0

16.00

25.04

mg/l

3.06

353

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.2

—

4.30

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.1

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

430

1.00

-0.00

26.1

13.5

94.09

88.01

ml/min/173m2

0.97

389

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.6

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

-0.00

0.0

2.4

—

0.50

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

-0.00

0.0

1.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

-0.00

0.0

1.6

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

-0.00

0.0

1.4

—

419.40

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

-0.00

0.0

2.8

—

5.51

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

5.8

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.2

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3023419) Bacteria identified in Sputum by Culture

0.00

-0.00

0.0

2.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint F5_ABUNONDEP and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
F5_ABUNONDEP	4.878 [3.14, 7.57]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.009

During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 279 males with F5_ABUNONDEP died.

Mortality risk

Mortality risk for people of age

years, who have F5_ABUNONDEP.

N-year risk	Females	Males
1	No data	0.902%
5	No data	5.273%
10	No data	12.758%
15	No data	24.307%
20	No data	38.78%

Relationships between endpoints

↥

Index endpoint: F5_ABUNONDEP – Abuse of non-dependence-producing substances

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Abuse of non-dependence-producing substances

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints