Juvenile osteochondrosis

M13_JUVOSTEOCHONRHIP

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M91, M92
  • Hospital discharge: ICD-9 7321X|732[3-6]
  • Hospital discharge: ICD-8 72209|7222[8-9]
  • Cause of death: ICD-10 M91, M92
  • Cause of death: ICD-9 7321X|732[3-6]
  • Cause of death: ICD-8 72209|7222[8-9]

2 out of 7 registries used, show all original rules.

1460

4. Check minimum number of events

None

1460

5. Include endpoints

None

1460

6. Filter based on genotype QC (FinnGen only)

1340

Control definitions (FinnGen only)

Control exclude
M13_OTHERBONE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17161 7115 10008
Only index persons 15939 6633 9306
Unadjusted period prevalence (%)
Whole population 0.25 0.20 0.28
Only index persons 0.31 0.24 0.36
Median age at first event (years)
Whole population 14.72 14.39 14.83
Only index persons 14.83 14.62 14.98

-FinnGen-

Key figures

All Female Male
Number of individuals 1340 763 577
Unadjusted period prevalence (%) 0.27 0.27 0.26
Median age at first event (years) 19.86 19.06 20.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1379
Matched controls
13790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M92.5
ICD-10 Finland
Juvenile osteochondrosis of tibia and fibula
370.8
307.7
315
11
M92.6
ICD-10 Finland
Juvenile osteochondrosis of tarsus
2456.1
234.1
220
*
M92.7
ICD-10 Finland
Juvenile osteochondrosis of metatarsus
1699.5
156.3
149
*
M91.1
ICD-10 Finland
Juvenile osteochondrosis of head of femur [Legg-Calvé-Perthes]
1336.1
127.2
122
*
9102
FHL
Trepanation or removal of the local bone process
44.0
112.1
67
16
72209
ICD-8 Finland
Osteochondrosis, spinalis juvenilis (Scheuermann) NUD
+∞
112.0
106
*
7324B
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of lower extremity, excluding foot[OSTEOCHONDROSIS JUVENILIS TUBEROSITATIS TIBIAE]
+∞
107.7
102
*
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
11.6
75.1
79
72
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
16.6
69.6
59
37
M92.4
ICD-10 Finland
Juvenile osteochondrosis of patella
679.8
66.5
65
*
M16.7
ICD-10 Finland
Other secondary coxarthrosis
18.1
54.3
44
25
M93.2
ICD-10 Finland
Osteochondritis dissecans
281.7
53.5
54
*
NGK05
NOMESCO Finland
Partial or total excision of bone of lower leg
90.1
47.2
52
6
M16.3
ICD-10 Finland
Other dysplastic coxarthrosis
17.9
43.0
35
20
M91.2
ICD-10 Finland
Coxa plana
+∞
42.9
41
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
8.0
40.6
56
73
M25.5
ICD-10 Finland
Pain in joint
2.1
37.9
531
3137
M79.6
ICD-10 Finland
Pain in limb
2.0
35.6
645
4165
M92.3
ICD-10 Finland
Other juvenile osteochondrosis of upper limb
+∞
32.4
31
*
NF1AA
NOMESCO Finland
Hip X-ray examination
3.4
31.5
117
361
M92.9
ICD-10 Finland
Juvenile osteochondrosis, unspecified
+∞
29.3
28
*
7325X
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of foot
+∞
29.3
28
*
N02AX02
ATC
tramadol; systemic, rectal
1.9
28.6
523
3320
NGK99
NOMESCO Finland
Other operation on bone of knee or lower leg
38.7
27.2
34
9
7323B
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of upper extremity[OSTEOCHONDROSIS JUVENILIS OSSIS LUNATUM CARPI]
+∞
27.2
26
*
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
3.5
26.5
93
276
7324X
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of lower extremity, excluding foot[OSTEOCHONDROSIS JUVENILIS EXTREMITATIS INFER ALIA]
+∞
26.1
25
*
7321A
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of hip and pelvis[COXA PLANA (LEGG-CALVô-PERTHES)]
265.4
25.8
26
*
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
8.4
25.3
33
40
M91.9
ICD-10 Finland
Juvenile osteochondrosis of hip and pelvis, unspecified
+∞
25.1
24
*
M92.8
ICD-10 Finland
Other specified juvenile osteochondrosis
254.6
24.7
25
*
M92.0
ICD-10 Finland
Juvenile osteochondrosis of humerus
+∞
24.0
23
*
M22.4
ICD-10 Finland
Chondromalacia patellae
4.1
23.9
67
170
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
3.4
23.7
87
266
ZXA05
NOMESCO Finland
Left side
2.1
23.3
271
1454
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
23.3
549
3715
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
9.2
23.0
28
31
M91.0
ICD-10 Finland
Juvenile osteochondrosis of pelvis
+∞
21.9
21
*
L13
ICPC
Hip symptom/complaint
2.1
21.6
226
1162
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
3.0
21.3
95
327
NHF25
NOMESCO Finland
Operation for debridement of ankle joint, arthroscopic
7.1
21.3
32
46
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.4
20.5
147
645
M92.2
ICD-10 Finland
Juvenile osteochondrosis of hand
+∞
19.8
19
*
M54.5
ICD-10 Finland
Low back pain
1.7
19.8
520
3587
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
19.8
587
4185
M77.4
ICD-10 Finland
Metatarsalgia
2.7
19.7
111
433
M01AH05
ATC
etoricoxib; oral
1.7
19.7
792
6120
N02BE01
ATC
paracetamol; systemic, rectal
2.0
19.3
1179
10244
M19.2
ICD-10 Finland
Other secondary arthrosis
7.0
19.1
29
42
M92.1
ICD-10 Finland
Juvenile osteochondrosis of radius and ulna
+∞
18.8
18
*
B01AB05
ATC
enoxaparin; parenteral
1.8
18.8
331
2029
Z3226
NOMESCO Finland
Physiotherapist
2.0
18.5
239
1323
M16.1
ICD-10 Finland
Other primary coxarthrosis
2.5
18.0
114
472
ZXA00
NOMESCO Finland
Right side
1.9
17.5
271
1591
N03AX16
ATC
[U] pregabalin
1.9
17.5
253
1454
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.2
17.5
154
738
M01AB05
ATC
diclofenac; systemic, rectal
1.6
17.2
795
6270
WX320
NOMESCO Finland
Spinalanesthesy
1.9
17.2
276
1640
72228
ICD-8 Finland
Osteochondrosis, Juvenilis, alia definita
+∞
16.7
16
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
16.6
534
3840
R4110
NOMESCO Finland
Physiotherapy
1.8
16.6
335
2128
NF1DA
NOMESCO Finland
X-ray of hips
4.8
16.2
36
76
M03BX02
ATC
tizanidine; oral
1.6
16.1
778
6160
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
2.6
15.7
92
366
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
15.6
120
542
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
3.7
15.4
49
136
NGK00
NOMESCO Finland
Partial or total excision of bone of patella
57.3
14.8
17
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.3
14.6
115
525
9165
FHL
Removal of osteosynthesis material
4.7
14.5
33
71
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.8
14.4
274
1705
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
14.3
366
2465
L17
ICPC
Foot/toe symptom/complaint
1.6
14.3
412
2862
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.1
14.2
142
713
N03AX12
ATC
[U] gabapentin; oral
1.9
14.1
179
981
1220
FHL
Arthroscopy
3.3
13.9
53
166
NEK20
NOMESCO Finland
Fenestration or forage of bone of pelvis
53.9
13.8
16
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
5.4
13.7
27
51
M02AA07
ATC
piroxicam; topical
1.7
13.7
331
2195
S18
ICPC
Laceration/cut
1.6
13.6
560
4215
72211
ICD-8 Finland
Osteochondrosis, Coxae planae
+∞
13.6
13
*
NFK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of femur
21.4
13.3
19
9
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.6
13.1
79
319
M01AE02
ATC
naproxen; oral, rectal
1.5
13.0
795
6495
M23.8
ICD-10 Finland
Other internal derangements of knee
2.8
13.0
64
233
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
2.8
12.9
63
228
A02BC02
ATC
pantoprazole; systemic
1.5
12.8
773
6290
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.5
12.7
78
318
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.9
12.6
163
897
SPAT1153
SPAT
Removal of sutures
1.6
12.6
323
2169
L15
ICPC
Knee symptom/complaint
1.6
12.6
327
2203
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
4.1
12.3
33
81
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
3.5
12.3
42
123
M01AC06
ATC
meloxicam; systemic, rectal
1.6
12.2
359
2491
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
5.6
12.1
23
42
M01AH01
ATC
celecoxib; oral
1.9
11.8
165
932
N06AX21
ATC
duloxetine; oral
1.9
11.7
156
867
NFB60
NOMESCO Finland
Demanding prosthetic replacement of hip
16.6
11.7
18
11
J01DB01
ATC
cefalexin; oral
1.6
11.5
1110
9879
J01FF01
ATC
clindamycin; systemic
1.6
11.5
309
2095
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
4.0
11.2
31
78
N02BF02
ATC
pregabalin; oral
2.3
11.2
90
414
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
3.0
11.2
50
173
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
3.0
11.0
47
158
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
3.7
11.0
34
93
M01AX17
ATC
nimesulide; oral
1.8
11.0
195
1184
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.8
10.9
170
993
X58
ICD-10 Finland
Exposure to other specified factors
1.7
10.8
239
1540
NGF40
NOMESCO Finland
Repair of defect of cartilage in the knee joint with transplant
28.3
10.7
14
5
A03FA02
ATC
cisapride; oral, rectal
2.4
10.7
77
338
M89.0
ICD-10 Finland
Algoneurodystrophy
21.6
10.7
15
7
N02AA05
ATC
oxycodone; systemic
1.9
10.7
146
818
NFK20
NOMESCO Finland
Epiphysiodesis of femur
60.5
10.6
12
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
10.6
406
2972
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.0
10.6
127
681
R03AC02
ATC
salbutamol; inhalant
1.5
10.6
731
6016
J01FA10
ATC
azithromycin; systemic
1.5
10.5
846
7163
M03BC01
ATC
orphenadrine (citrate); systemic
1.6
10.5
278
1873
M93.1
ICD-10 Finland
Kienböck disease of adults
110.8
10.4
11
*
7324A
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of lower extremity, excluding foot[TIBIA VARA (BLOUNT)]
+∞
10.4
10
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.0
10.4
123
656
ZXD20
NOMESCO Finland
Day surgery
1.8
10.4
153
877
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.1
10.4
106
537
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.4
10.3
36
107
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
2.4
10.1
69
296
TNX34
NOMESCO Finland
Major custom molded cast, unspecified region
4.4
10.1
25
58
H02AB06
ATC
prednisolone; systemic
1.5
9.9
531
4145
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
9.9
341
2437
A02BC01
ATC
omeprazole; systemic
1.6
9.9
287
1974
L03
ICPC
Low back symptom/complaint
1.5
9.8
397
2933
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
9.8
298
2071
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
9.7
597
4779
R51.80
ICD-10 Finland
Headache
1.6
9.7
248
1654
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
3.5
9.6
33
97
M01AH03
ATC
valdecoxib; oral
2.4
9.6
62
260
NGF20
NOMESCO Finland
Operation for osteochondritis of knee, open
11.5
9.6
17
15
M93.9
ICD-10 Finland
Osteochondropathy, unspecified
100.7
9.4
10
*
9407
FHL
Osteotomy of the upper femur
100.7
9.4
10
*
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
2.5
9.2
58
240
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
9.2
237
1584
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
9.1
370
2728
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
9.1
260
1778
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.7
9.1
166
1014
M54.4
ICD-10 Finland
Lumbago with sciatica
1.6
9.1
219
1439
M01AE01
ATC
ibuprofen; systemic, rectal
1.7
9.0
1229
11398
L86
ICPC
Back syndrome with radiating pain
2.2
8.8
75
354
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
8.7
367
2722
WX702
NOMESCO Finland
Supraglottic ventilation device
2.2
8.7
73
343
R03AK07
ATC
formoterol and budesonide; inhalant
1.5
8.7
268
1864
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
3.4
8.7
30
89
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
8.6
1035
9263
ZXE00
NOMESCO Finland
One hour or less
1.4
8.6
454
3517
M01AH02
ATC
rofecoxib; oral
2.0
8.4
97
513
J01DA01
ATC
[U] cefalexin
1.4
8.4
728
6134
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
3.3
8.4
30
91
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
3.0
8.3
35
117
7326A
ICD-9 Finland
Osteochondropathies, Other juvenile osteochondrosis
+∞
8.3
8
*
72219
ICD-8 Finland
Osteochondrosis, Coxae juvenilis NUD
+∞
8.3
8
*
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
2.2
8.2
64
292
J01DA09
ATC
[U] cefadroxil
1.5
8.2
309
2239
M02AA10
ATC
ketoprofen; topical
1.7
8.2
145
878
L28
ICPC
Limited function/disability (L)
1.7
8.0
161
1010
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
2.8
7.9
38
137
NH1AD
NOMESCO Finland
Ankle and foot CT
2.9
7.9
36
126
M54.3
ICD-10 Finland
Sciatica
2.2
7.9
65
303
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
7.9
287
2063
9103
FHL
Partial or complete bone removal
13.1
7.9
13
10
J01AA02
ATC
doxycycline; systemic
1.4
7.8
849
7386
M67.4
ICD-10 Finland
Ganglion
1.9
7.8
91
484
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
2.5
7.8
46
185
S93.4
ICD-10 Finland
Sprain and strain of ankle
1.6
7.8
204
1365
L08
ICPC
Shoulder symptom/complaint
1.5
7.7
252
1770
RF210, ,
NOMESCO Finland
2.7
7.7
39
145
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.7
7.6
136
826
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
2.2
7.6
65
309
RF410, ,
NOMESCO Finland
4.1
7.5
20
49
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
3.3
7.5
28
87
72870
ICD-8 Finland
Vertebrogenic pain syndrome, Lumbalgia
7.2
7.5
17
24
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.9
7.5
86
456
RF420, ,
NOMESCO Finland
3.9
7.4
21
54
R06.2
ICD-10 Finland
Wheezing
2.1
7.4
70
345
M54
ICD-10 Finland
Dorsalgia
1.6
7.4
173
1126
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
2.6
7.4
42
166
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
7.4
219
1507
7323X
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of upper extremity[OSTEOCHONDROSIS JUVENILIS EXTREMITATIS SUPER ALIA]
+∞
7.3
7
*
72220
ICD-8 Finland
Osteochondrosis, Malacia ossia lunati (Kienböck)
+∞
7.3
7
*
7327A
ICD-9 Finland
Osteochondropathies, Osteochondritis dissecans[OSTEOCHONDRITIS DISSECANS GENUS]
+∞
7.3
7
*
M20.1
ICD-10 Finland
Hallux valgus (acquired)
2.0
7.3
74
375
R06AE07
ATC
cetirizine; oral
1.4
7.3
574
4724
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
3.4
7.3
25
74
R06.0
ICD-10 Finland
Dyspnoea
1.5
7.2
278
2017
NGF30
NOMESCO Finland
Fixation of loose body of joint of knee
15.8
7.2
11
7
NB1AE, ,
SPAT
2.5
7.1
44
181
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
7.1
999
8991
M01AB01
ATC
indometacin; systemic, rectal
2.3
7.1
54
244
WX214
NOMESCO Finland
Plexus blockade at the ankle
12.1
7.1
12
10
R52.2
ICD-10 Finland
Other chronic pain
2.3
7.1
49
213
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
2.5
7.1
41
164
J45.9
ICD-10 Finland
Asthma, unspecified
1.5
7.0
218
1513
AA1AD
NOMESCO Finland
CT of head and brain
1.5
7.0
247
1762
H81.9
ICD-10 Finland
Disorder of vestibular function, unspecified
4.4
7.0
17
39
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
7.0
251
1798
L16
ICPC
Ankle symptom/complaint
1.6
6.9
175
1160
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
6.9
273
1991
M48.0
ICD-10 Finland
Spinal stenosis
1.9
6.9
90
498
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.7
6.8
132
818
NCF25
NOMESCO Finland
Operation for osteochondritis of elbow joint, arthroscopic
8.3
6.8
14
17
9254
FHL
Arthrotomy (includes biopsy, revision, loose removal, fixation, and similar procedures)
8.3
6.8
14
17
NHF30
NOMESCO Finland
Fixation of loose fragment from ankle joint
40.3
6.8
8
*
9527
FHL
Alloarthroplasty, implant or endoprosthesis
40.3
6.8
8
*
NGL58
NOMESCO Finland
Tenolysis or tenosynovectomy of knee or lower leg
40.3
6.8
8
*
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.7
6.7
138
869
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.3
6.6
703
6023
R4110, ,
SPAT
1.7
6.6
132
825
JN3AD
NOMESCO Finland
Abdominal CT examination
1.7
6.6
135
849
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
6.6
1003
9075
M67.8
ICD-10 Finland
Other specified disorders of synovium and tendon
3.6
6.6
21
59
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.6
6.6
145
931
T14.0
ICD-10 Finland
Superficial injury of unspecified body region
3.7
6.5
20
55
M76.5
ICD-10 Finland
Patellar tendinitis
3.1
6.5
26
85
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.3
6.5
45
196
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
6.2
6.5
16
26
A01
ICPC
Pain general/multiple sites
1.7
6.4
114
691
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.7
6.4
131
824
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
2.8
6.4
31
113
A02BC05
ATC
esomeprazole; systemic
1.4
6.4
407
3223
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
6.4
604
5081
WX002
NOMESCO Finland
Sedation and analgesia
1.5
6.3
178
1209
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
6.3
410
3255
J01
ICD-10 Finland
Acute sinusitis
1.8
6.3
84
469
M91.3
ICD-10 Finland
Pseudocoxalgia
+∞
6.3
6
*
M93.8
ICD-10 Finland
Other specified osteochondropathies
+∞
6.3
6
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
1.8
6.2
83
462
E66.01
ICD-10 Finland
Obesity due to excess calories
1.6
6.2
137
879
L12
ICPC
Hand/finger symptom/complaint
1.5
6.2
243
1767
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.4
6.2
410
3264
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
6.1
708
6115
R42
ICD-10 Finland
Dizziness and giddiness
1.5
6.1
216
1541
C07AB02
ATC
metoprolol; systemic
1.6
6.0
138
893
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
1.9
6.0
70
373
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
6.0
218
1561

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
448
3353
1.50
10.52
2.8
2.6
59.07
60.25
u/l
0.11
416
3132
654
5310
1.44
9.91
3.0
2.7
—
—
estimate
—
0
0
758
6327
1.44
9.87
5.8
5.2
6.46
6.45
mmol/l
0.04
714
5853
940
8213
1.45
9.25
8.2
7.5
76.67
77.28
u/l
0.18
901
7836
654
5414
1.40
8.37
6.5
6.1
10.22
11.23
umol/l
2.85
627
5143
456
3564
1.42
8.08
3.2
3.1
32.06
55.56
ng/l
0.54
240
2046
374
2873
1.41
7.16
2.5
2.1
413.96
246.08
u/l
0.39
360
2742
1167
10813
1.52
7.09
5.6
5.0
1.83
1.81
mu/l
0.12
1115
10241
1024
9272
1.41
6.92
4.6
4.2
14.49
14.51
pmol/l
0.10
966
8614
336
2561
1.41
6.66
3.4
2.7
333.48
335.98
umol/l
0.17
308
2346
338
2611
1.39
6.14
2.0
2.0
0.89
1.05
mg/l
0.79
252
1931
504
4147
1.34
6.11
12.6
9.7
1.15
1.15
inr
0.03
431
3436
836
7405
1.33
6.01
4.5
4.0
2172.80
944.68
e6/l
0.26
15
90
582
4910
1.32
5.87
8.6
7.3
1.21
1.21
mmol/l
0.24
508
4287
150
999
1.56
5.82
1.4
1.3
903.33
338.50
u/ml
0.41
143
939
154
1033
1.55
5.79
4.2
3.4
1.73
1.73
%
0.02
138
938
438
3558
1.34
5.71
2.6
2.2
—
—
—
0
0
521
4356
1.32
5.51
7.7
7.0
1.21
1.21
mmol/l
1.07
491
4060
1240
11769
1.53
5.37
16.3
12.5
20.06
21.85
mg/l
1.26
1047
9391
51
255
2.04
5.28
4.1
9.4
1.31
1.22
mmol/l
0.43
42
214
20
64
3.16
5.20
4.3
4.4
191.64
154.81
umol/l
0.31
14
36
434
3560
1.32
5.20
1.5
1.4
1.60
1.72
u/ml
0.06
120
983
338
2685
1.34
5.03
2.6
2.2
—
—
—
0
0
264
2026
1.37
4.89
1.3
1.3
8.29
8.71
u/ml
0.04
100
829
1198
11334
1.43
4.85
17.2
13.5
139.45
139.61
mmol/l
1.70
1187
11082
24
91
2.67
4.67
1.5
1.6
56.28
53.33
%
0.15
18
69
59
325
1.85
4.65
3.9
8.0
0.81
0.88
%
1.07
53
301
321
2560
1.33
4.61
4.7
4.2
—
—
—
0
0
25
98
2.58
4.56
1.1
1.1
100.52
113.24
pmol/l
0.83
25
98
511
4344
1.28
4.55
5.6
5.1
37.43
37.07
g/l
0.81
488
4103
1279
12284
1.57
4.53
18.5
14.7
75.06
73.09
umol/l
1.27
1272
12147
236
1802
1.37
4.50
3.7
3.4
669.23
602.05
ng/l
0.07
150
1167
35
163
2.18
4.39
1.5
1.6
—
—
—
0
0
364
2974
1.30
4.37
3.3
3.0
0.35
0.35
e6/l
0.02
266
2128
377
3099
1.30
4.32
1.6
1.5
2.12
2.19
g/l
0.37
263
1994
196
1461
1.40
4.31
2.4
2.0
—
—
—
0
0
1196
11358
1.40
4.30
17.5
13.6
3.95
3.93
mmol/l
0.91
1184
11078
504
4305
1.27
4.24
2.0
1.9
97.65
96.14
pmol/l
0.30
266
2429
174
1275
1.42
4.22
3.8
2.9
6.31
7.11
umol/l
0.38
150
1103
34
160
2.15
4.18
4.9
12.8
11.25
11.41
mmol/l
0.10
28
142
352
2879
1.30
4.17
4.1
3.9
7.40
7.39
ph
0.47
250
2010
63
367
1.75
4.17
3.8
7.4
1.68
1.60
%
0.22
57
341
151
1083
1.44
4.12
6.2
4.8
7.38
7.38
ph
0.01
92
643
34
161
2.14
4.12
4.9
12.8
104.75
105.27
mmol/l
0.31
28
143
180
1341
1.39
3.98
9.0
6.8
1.05
1.07
mmol/l
0.45
173
1257
402
3365
1.27
3.95
3.1
3.1
2.35
2.35
mmol/l
0.41
372
3112
474
4048
1.26
3.93
3.7
3.3
32.97
31.42
u/l
0.20
452
3858
586
5128
1.25
3.93
3.1
3.1
6.23
6.20
ph
0.26
311
2900
712
6369
1.24
3.90
3.6
3.4
0.02
0.25
estimate
0.45
146
1247
24
100
2.42
3.90
1.1
1.0
—
—
—
0
0
286
2297
1.31
3.85
2.8
2.6
5.61
7.00
e6/l
0.83
255
2087
1115
10524
1.31
3.79
4.4
4.0
5.80
5.74
mmol/l
0.77
1042
9874
179
1345
1.38
3.76
1.7
1.6
—
—
—
0
0
79
505
1.60
3.72
10.1
14.0
16.40
16.22
%
0.22
72
483
277
2229
1.30
3.67
1.3
1.3
30.95
25.10
iu/ml
0.28
70
630
706
6340
1.23
3.63
3.6
3.4
9.17
4.83
estimate
0.19
147
1302
42
227
1.88
3.58
1.6
1.6
17186.23
15391.81
e6/l
0.09
26
163
403
3411
1.26
3.55
3.6
3.1
27.89
73.95
e6/l
1.32
311
2557
229
1804
1.32
3.53
1.5
1.4
504.15
481.27
titre
0.07
53
347
29
138
2.13
3.51
1.1
1.1
0.39
1.81
u/ml
0.56
16
58
109
762
1.47
3.43
3.8
3.1
65.84
70.90
e9/l
0.72
84
543
704
6349
1.22
3.38
7.6
6.7
1.97
1.99
e9/l
0.16
636
5666
122
875
1.43
3.36
9.4
11.5
95.29
95.90
%
0.32
114
847
328
2730
1.26
3.31
5.0
4.1
89.93
92.51
%
1.19
322
2672
141
1041
1.39
3.30
6.4
4.8
1.23
1.53
mmol/l
0.64
130
896
1271
12287
1.44
3.30
11.9
10.1
28.01
27.32
u/l
0.50
1244
12013
696
6283
1.22
3.27
3.5
3.3
0.00
0.00
estimate
0.50
146
1312
15
54
2.80
3.26
1.2
1.6
—
—
—
0
0
225
1791
1.31
3.22
3.0
2.7
0.97
0.99
e6/l
0.02
123
887
749
6821
1.21
3.18
10.5
9.3
4.11
4.01
e9/l
0.61
659
5949
576
5113
1.22
3.17
2.7
2.5
74.13
72.16
nmol/l
0.87
544
4781
117
844
1.42
3.14
2.2
2.4
17.09
17.84
au/ml
0.06
14
106
647
5815
1.21
3.13
7.6
6.5
56.21
56.06
%
0.13
621
5590
74
489
1.54
3.07
4.6
8.9
24.40
24.33
mmol/l
0.05
68
462
924
8620
1.22
2.96
3.6
3.2
42.95
40.42
u/l
0.62
882
8274
72
477
1.54
2.96
1.3
1.2
0.45
1.15
u/ml
—
6
28
477
4179
1.22
2.95
4.3
3.7
55.34
83.62
e6/l
0.54
325
2773
348
2953
1.24
2.93
2.5
2.2
2.54
2.61
mg/l
0.28
300
2581
132
985
1.38
2.92
9.1
10.6
12.66
13.04
kpa
0.38
125
949
132
985
1.38
2.92
9.1
10.6
4.96
5.09
kpa
0.96
125
945
14
52
2.71
2.89
1.1
1.4
40170.00
16104.80
e6/l
—
9
25
708
6450
1.20
2.88
3.6
3.2
96.07
93.12
ug/l
0.14
672
6129
131
980
1.37
2.86
9.3
10.7
7.42
7.41
ph
0.55
67
520
678
6163
1.20
2.80
7.7
6.6
0.57
0.56
e9/l
0.87
596
5365
10
28
3.59
2.78
3.2
1.6
—
—
—
0
0
678
6169
1.19
2.75
7.8
6.7
0.04
0.04
e9/l
0.34
593
5371
58
373
1.58
2.73
1.8
2.1
1.47
1.40
g/l
0.20
48
340
29
153
1.91
2.71
1.4
1.2
—
45.71
—
0
9
653
5926
1.19
2.71
7.8
6.6
28.90
29.50
%
0.78
623
5668
470
4140
1.21
2.71
2.0
2.0
—
—
—
0
0
107
782
1.40
2.70
1.3
1.3
60.72
44.95
au/ml
—
5
52
415
3619
1.21
2.65
2.6
2.6
0.17
0.05
—
6
43
235
1933
1.26
2.60
1.7
1.6
29949660.00
28965115.23
pmol/l
0.01
197
1671
352
3026
1.22
2.59
4.7
4.6
—
—
—
0
0
696
6369
1.19
2.59
8.1
7.0
0.20
0.19
e9/l
1.01
622
5631
630
5717
1.19
2.58
8.0
6.8
8.49
8.59
%
0.42
594
5409
138
1061
1.33
2.55
2.6
2.5
41.97
83.09
u/l
0.42
119
897
131
1000
1.34
2.54
3.2
2.7
10.09
10.51
g/l
0.71
119
928
76
528
1.47
2.53
2.8
3.1
120.29
172.23
ng/l
1.11
70
466
111
826
1.37
2.53
10.2
11.9
123.17
123.96
g/l
0.14
104
807
16
69
2.33
2.49
1.1
1.5
33.61
32.73
g/l
0.11
16
62
73
506
1.47
2.47
2.5
1.9
3.98
6.15
iu/ml
0.85
22
108
23
116
2.00
2.46
4.3
2.3
39.31
40.60
%
0.19
23
116
125
953
1.34
2.45
11.2
10.3
—
—
—
0
0
13
51
2.56
2.44
1.1
1.3
—
—
—
0
0
87
625
1.42
2.44
2.7
2.5
65.98
67.52
g/l
0.99
82
592
207
1690
1.26
2.44
3.2
2.8
2.70
2.76
e6/l
0.03
106
791
127
974
1.33
2.39
9.3
10.7
0.42
0.66
mmol/l
0.28
104
804
97
715
1.38
2.35
1.3
1.2
—
—
—
0
0
69
478
1.47
2.35
2.1
2.2
—
—
—
0
0
624
5691
1.18
2.33
8.1
6.8
0.64
0.67
%
0.72
588
5375
318
2733
1.21
2.33
1.9
1.6
19.17
19.76
nmol/l
0.36
282
2380
625
5705
1.17
2.30
8.0
6.7
2.78
2.83
%
0.18
591
5383
181
1466
1.27
2.28
3.2
2.6
22.72
23.94
%
0.59
168
1370
52
342
1.54
2.27
1.2
1.2
—
—
—
0
0
29
164
1.78
2.24
1.4
1.4
—
—
—
0
0
1062
10143
1.20
2.23
5.8
5.0
38.06
37.74
mmol/mol
0.57
1022
9699
14
60
2.35
2.22
1.1
1.4
—
—
—
0
0
61
419
1.48
2.19
1.1
1.1
1.56
7.22
eliau/ml
—
9
67
105
798
1.34
2.13
1.1
1.2
—
—
—
0
0
154
1236
1.28
2.10
1.2
1.2
—
—
—
0
0
71
507
1.42
2.09
4.9
3.7
0.59
0.61
%
0.22
71
507
49
325
1.53
2.08
1.5
2.0
6.99
2.27
ug/l
0.50
44
293
26
146
1.80
2.07
1.0
1.1
0.59
1.61
u/ml
—
9
54
50
334
1.52
2.06
1.0
1.1
5.56
6.82
u/ml
0.14
22
156
25
139
1.81
2.06
1.4
1.6
—
—
—
0
0
6
15
4.01
2.04
1.0
1.1
—
—
—
0
0
32
193
1.67
2.01
3.0
3.3
15.37
2.38
ratio
0.45
20
101
104
797
1.33
2.01
2.1
1.8
1.20
1.31
g/l
0.48
98
744
198
1647
1.24
2.00
6.0
4.0
0.82
0.82
mmol/l
0.15
193
1571
83
615
1.37
1.99
1.1
1.1
—
—
—
0
0
124
976
1.30
1.98
4.1
5.0
1.03
0.91
%
0.10
36
284
13
57
2.29
1.98
1.1
1.3
137.62
144.31
nmol/l
0.19
13
57
337
2956
1.19
1.96
2.7
2.5
—
—
—
0
0
67
480
1.42
1.96
3.4
3.0
21.18
20.79
s
0.31
56
432
82
609
1.37
1.94
2.3
2.2
5.07
8.43
ug/l
1.58
71
551
149
1205
1.27
1.93
1.3
1.4
—
—
—
0
0
207
1738
1.22
1.91
3.1
2.5
13.37
14.33
umol/l
1.25
191
1620
592
5445
1.15
1.86
11.7
10.3
0.00
0.00
e9/l
1.07
483
4447
13
59
2.21
1.84
6.1
2.6
0.17
0.20
e9/l
—
8
31
5
12
4.18
1.82
1.8
5.8
—
3.68
—
0
5
1155
11176
1.21
1.82
5.1
4.6
2.76
2.78
mmol/l
0.27
1097
10644
442
3985
1.16
1.82
8.2
6.7
—
—
—
0
0
194
1629
1.22
1.80
3.1
2.5
2.36
2.40
g/l
0.46
179
1507
526
4806
1.15
1.80
3.3
3.1
0.03
0.02
estimate
0.34
124
1105
59
422
1.42
1.76
2.0
2.2
—
—
—
0
0
138
1120
1.26
1.75
3.3
2.4
1795.04
6790.71
u/l
3.11
47
430
203
1719
1.21
1.74
2.4
2.6
2.42
2.42
mmol/l
0.50
179
1539
118
941
1.28
1.73
4.0
5.0
0.06
0.12
%
0.51
31
248
106
834
1.29
1.72
1.6
1.6
334.35
299.60
mu/l
0.40
97
747
8
30
2.68
1.72
1.3
1.0
—
—
—
0
0
8
30
2.68
1.72
1.3
1.0
—
—
—
0
0
8
30
2.68
1.72
1.3
1.0
—
—
—
0
0
126
1014
1.27
1.72
2.0
2.0
0.00
0.02
estimate
0.78
28
249
22
126
1.76
1.68
3.1
1.9
—
—
—
0
0
116
927
1.27
1.68
10.6
9.4
1.25
1.34
mmol/l
0.64
116
909
323
2859
1.17
1.67
3.3
3.3
1.02
1.02
kg/l
0.95
202
1833
51
359
1.44
1.67
1.1
1.1
3.71
4.77
u/ml
0.30
23
178
376
3368
1.16
1.67
3.6
3.4
0.00
0.01
estimate
1.34
140
1238
160
1328
1.23
1.67
1.5
1.4
—
—
—
0
0
6
19
3.17
1.66
1.3
1.3
—
—
—
0
0
116
929
1.27
1.65
3.8
4.7
0.56
0.60
%
0.09
32
267
7
25
2.81
1.65
1.0
1.7
—
—
—
0
0
234
2021
1.19
1.63
3.1
2.7
560.91
551.09
mosm/kgh2o
0.24
200
1789
230
1984
1.19
1.62
2.8
2.8
93.85
107.98
ug/g
0.40
189
1612
58
421
1.39
1.62
1.2
1.2
—
—
—
0
0
1145
11102
1.18
1.59
4.7
4.3
4.64
4.64
mmol/l
0.06
1095
10612
1077
10393
1.17
1.58
4.0
3.6
1.33
1.26
mmol/l
1.70
1027
9845
53
381
1.41
1.57
1.4
1.2
—
—
—
0
0
1328
13089
1.39
1.55
24.1
19.0
257.68
256.43
e9/l
0.30
1307
12864
5
15
3.34
1.52
1.0
1.1
0.05
0.02
u/ml
—
5
15
65
487
1.35
1.51
1.1
1.2
1.22
3.35
u/ml
1.65
33
263
117
951
1.25
1.49
4.3
5.4
0.04
0.15
%
1.03
27
231
20
116
1.73
1.49
1.3
1.2
—
—
—
0
0
1328
13097
1.38
1.46
23.9
18.9
30.14
30.08
pg
0.65
1320
12996
1328
13097
1.38
1.46
24.0
19.0
4.57
4.60
e12/l
1.06
1306
12845
1328
13097
1.38
1.46
24.6
19.4
40.87
41.57
%
0.92
1319
12989
170
1442
1.20
1.45
2.5
3.0
4.08
5.10
e9/l
1.40
149
1280
49
353
1.40
1.45
1.5
1.2
1.52
10.18
u/ml
—
5
52
33
221
1.51
1.42
1.8
1.9
0.75
0.79
g/l
0.08
25
183
167
1418
1.20
1.41
1.3
1.2
—
—
—
0
0
37
254
1.47
1.41
2.4
2.4
—
—
—
0
0
1138
11055
1.17
1.41
4.5
4.2
1.41
1.42
mmol/l
0.46
1081
10522
72
555
1.31
1.40
2.2
2.0
0.04
1.23
estimate
0.48
26
204
1328
13103
1.37
1.39
24.2
19.1
137.18
137.55
g/l
0.43
1320
12998
1328
13103
1.37
1.39
24.1
19.0
6.83
6.71
e9/l
1.55
1305
12845
7
29
2.42
1.39
1.7
1.1
—
—
—
0
0
18
104
1.74
1.37
1.2
1.2
—
—
—
0
0
18
104
1.74
1.37
4.8
3.9
—
—
—
0
0
1327
13094
1.36
1.36
23.9
18.9
90.02
89.86
fl
0.68
1319
12994
23
143
1.62
1.35
3.2
3.2
15.61
25.76
mu/l
1.66
23
134
10
47
2.14
1.34
1.2
1.3
—
—
—
0
0
13
68
1.92
1.33
1.9
3.2
20.68
479.54
ug/l
0.68
13
61
313
2812
1.15
1.33
4.8
4.3
10.12
9.40
mg/mmol
0.11
214
1835
36
250
1.45
1.31
1.0
1.1
1.22
2.69
eliau/ml
2.11
22
118
67
517
1.31
1.31
5.1
4.3
—
—
—
0
0
32
218
1.48
1.29
3.3
3.4
30.08
39.46
mg/l
0.41
25
184
32
218
1.48
1.29
3.3
3.4
176.52
71.89
mg/l
0.36
25
184
11
55
2.01
1.27
1.4
1.3
—
—
—
0
0
403
3692
1.13
1.26
2.9
2.7
0.01
0.03
estimate
0.49
122
1066
306
2755
1.14
1.26
4.0
3.6
56.37
55.79
mg/l
0.02
209
1845
15
85
1.77
1.23
1.1
1.3
7.13
7.08
mm/h
0.01
15
85
11
56
1.97
1.22
1.4
1.4
166.64
178.08
mmol/24h
0.22
11
56
58
444
1.32
1.21
1.1
1.1
8.70
6.40
u/ml
0.31
26
268
20
124
1.62
1.21
1.1
1.1
18.34
6.55
iu/ml
—
7
33
85
685
1.26
1.21
1.1
1.1
—
—
—
0
0
175
1516
1.18
1.21
3.2
2.5
29.78
29.43
s
0.42
170
1482
21
132
1.60
1.20
1.0
1.1
0.55
5.71
u/ml
—
6
45
24
156
1.55
1.20
2.0
2.3
—
—
—
0
0
56
428
1.32
1.19
1.1
1.1
3.59
2.07
u/ml
0.21
27
228
56
428
1.32
1.19
1.3
1.1
—
—
—
0
0
23
150
1.54
1.14
3.3
3.7
2.17
1.40
%
0.20
18
140
34
241
1.42
1.14
1.5
1.1
—
—
—
0
0
159
1374
1.18
1.14
1.7
1.5
—
—
—
0
0
306
2777
1.13
1.12
2.1
2.0
—
—
—
0
0
249
2230
1.14
1.11
3.2
3.4
1122.17
992.10
ng/l
0.22
205
1813
451
4188
1.11
1.11
2.4
2.2
—
—
—
0
0
13
73
1.79
1.11
1.2
1.1
—
—
—
0
0
46
346
1.34
1.10
1.8
1.4
—
—
—
0
0
96
798
1.22
1.06
3.0
3.7
4.71
4.68
pmol/l
0.12
84
727
11
60
1.84
1.03
2.8
3.2
—
—
—
0
0
104
875
1.20
1.02
1.6
1.5
15.18
18.91
iu/l
1.03
90
719
9
47
1.92
1.02
1.3
3.6
16.14
17.01
%
—
9
47
95
795
1.21
0.99
5.5
3.9
7.35
7.34
ph
0.38
78
582
62
496
1.26
0.97
1.7
1.7
7.27
7.36
u/ml
0.01
18
126
8
142
0.56
0.93
1.5
1.2
—
—
—
0
0
485
4557
1.10
0.93
1.9
1.9
1.58
1.38
mmol/l
1.57
425
4023
42
322
1.31
0.92
1.0
1.1
0.50
0.31
u/ml
0.26
13
103
17
110
1.55
0.90
1.8
2.0
33.35
32.77
pg
0.25
17
110
87
730
1.20
0.90
4.8
4.0
7.42
7.41
ph
0.59
69
612
383
3565
1.10
0.89
4.0
3.6
8.06
8.47
mmol/l
0.97
347
3131
89
750
1.20
0.88
1.8
1.7
0.35
0.29
mg/l
0.41
44
360
54
431
1.26
0.88
1.1
1.1
0.63
1.12
u/ml
0.63
20
202
238
2166
1.12
0.85
2.0
1.7
—
—
—
0
0
6
31
1.94
0.84
2.2
2.2
—
—
—
0
0
8
45
1.78
0.84
1.0
1.1
44.84
42.99
iu/ml
—
8
45
165
1847
0.88
0.83
1.7
1.8
3.55
3.53
ratio
0.05
116
1369
124
1416
0.86
0.83
1.5
1.6
3.65
3.43
mmol/l
1.19
84
947
41
319
1.29
0.83
8.5
9.1
—
—
—
0
0
29
214
1.36
0.83
4.2
3.3
20.64
24.95
mg/l
0.36
20
141
36
275
1.32
0.82
2.5
1.6
—
—
—
0
0
12
73
1.65
0.81
3.3
3.9
793.92
644.88
u/ml
0.24
12
73
26
190
1.38
0.79
1.0
1.2
—
—
—
0
0
8
48
1.67
0.78
2.8
2.5
—
—
—
0
0
148
1315
1.14
0.78
1.7
1.7
1276.51
1167.21
nmol/l
0.72
118
1019
88
751
1.18
0.78
1.4
1.3
248.40
239.23
miu/ml
0.07
35
369
28
208
1.35
0.78
1.1
1.3
2.44
5.31
u/ml
—
9
95
19
132
1.45
0.76
1.7
1.4
2.88
2.66
g/l
0.27
14
100
19
132
1.45
0.76
1.7
1.4
6.00
6.33
g/l
0.26
14
101
19
132
1.45
0.76
1.7
1.4
0.31
0.35
g/l
0.25
14
99
12
75
1.61
0.75
1.3
1.2
—
56.00
—
0
6
126
1112
1.15
0.74
1.3
1.2
203.07
138.22
u/ml
0.78
51
431
37
290
1.28
0.73
2.5
1.6
5.04
12.00
e6/l
1.07
27
210
5
25
2.00
0.72
2.2
2.0
1310.00
348.84
e6/l
—
5
19
27
203
1.34
0.71
3.1
3.1
1.76
1.45
mmol/l
0.49
27
196
5
26
1.93
0.70
1.2
1.4
6.00
12.19
mmol/l
—
5
26
19
135
1.41
0.69
1.3
1.3
—
—
—
0
0
13
85
1.53
0.69
1.2
1.1
—
—
—
0
0
7
42
1.67
0.68
1.0
1.5
—
—
—
0
0
45
366
1.24
0.67
1.2
1.4
3.57
3.29
ug/l
0.25
45
343
7
43
1.63
0.67
1.0
1.3
2.94
1.24
u/ml
—
7
43
90
783
1.16
0.66
1.3
1.3
—
—
—
0
0
5
28
1.79
0.66
1.0
1.3
—
8.50
%
—
0
6
54
449
1.21
0.66
1.4
1.3
—
—
—
0
0
66
560
1.19
0.65
1.4
1.3
—
—
—
0
0
37
296
1.26
0.64
2.5
1.6
876.32
932.79
e6/l
0.03
28
227
41
333
1.24
0.63
1.4
1.5
0.30
0.36
nmol/l
0.50
36
274
8
50
1.60
0.61
6.5
3.5
—
—
—
0
0
362
3419
1.08
0.61
7.7
5.9
—
—
—
0
0
27
209
1.30
0.60
2.3
2.5
—
24.36
—
0
14
8
51
1.57
0.60
1.3
3.3
8.16
8.45
mmol/l
—
8
51
17
122
1.40
0.60
1.2
1.1
—
—
—
0
0
12
80
1.50
0.60
3.0
2.5
37.78
45.12
%
—
5
38
8
52
1.54
0.59
2.8
2.5
—
—
—
0
0
21
157
1.34
0.59
3.6
3.2
10.16
7.20
mmol/l
0.63
21
152
16
114
1.41
0.59
1.2
1.1
—
—
—
0
0
8
54
1.48
0.57
1.4
1.7
—
3430.00
—
0
8
8
54
1.48
0.57
2.3
1.8
—
—
—
0
0
12
81
1.49
0.57
3.5
2.5
1.19
1.19
mmol/l
0.15
12
81
6
37
1.62
0.55
4.5
2.1
162.33
113.80
ng/l
—
6
37
12
82
1.47
0.54
3.5
2.5
4.40
4.03
mmol/l
0.62
12
82
12
82
1.47
0.54
3.5
2.5
102.92
105.73
mmol/l
1.21
12
82
40
331
1.21
0.54
2.5
2.3
6.83
5.21
umol/l
0.30
27
253
55
470
1.18
0.53
3.0
2.9
1.02
1.02
ratio
1.28
50
426
25
196
1.28
0.52
1.2
1.3
—
—
—
0
0
10
66
1.52
0.52
1.0
1.3
—
—
—
0
0
6
41
1.47
0.50
1.0
1.3
26.67
28.61
s
—
6
41
6
41
1.47
0.50
2.3
1.7
—
—
—
0
0
7
45
1.56
0.49
1.0
1.1
—
—
—
0
0
7
46
1.52
0.48
1.0
1.0
—
—
—
0
0
28
226
1.24
0.48
2.3
2.4
128.29
132.43
g/l
0.29
21
188
260
2451
1.07
0.47
1.7
1.6
—
—
—
0
0
37
309
1.20
0.47
1.1
1.1
16.03
14.90
au/ml
—
7
92
29
237
1.23
0.45
1.1
1.1
24.26
125.95
iu/ml
—
5
64
33
274
1.21
0.45
1.2
1.1
—
—
—
0
0
80
715
1.13
0.44
3.2
4.4
4.71
13.98
ug/l
0.83
65
564
288
2734
1.07
0.44
4.0
4.3
1.73
1.89
ug/l
0.23
261
2509
39
331
1.18
0.43
1.9
1.4
151.00
145.46
au/ml
—
9
100
138
1492
0.92
0.42
1.9
1.9
—
—
—
0
0
17
131
1.30
0.42
1.8
1.4
—
—
—
0
0
5
34
1.47
0.40
2.0
1.9
—
—
—
0
0
17
132
1.29
0.40
2.5
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
14
106
1.32
0.39
2.1
2.7
1.85
1.51
g/24h
—
7
73
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
42
363
1.16
0.39
1.3
1.1
—
—
—
0
0
16
203
0.79
0.38
2.2
3.0
6.93
7.52
pmol/l
0.18
16
203
12
89
1.35
0.38
1.0
1.1
—
—
—
0
0
42
364
1.16
0.37
1.3
1.1
—
—
—
0
0
96
878
1.10
0.37
2.6
3.1
—
—
—
0
0
23
188
1.23
0.37
3.7
3.8
—
—
—
0
0
5
37
1.35
0.37
1.4
1.5
71.20
87.49
nmol/24h
—
5
37
80
726
1.11
0.36
3.2
3.5
1.21
1.23
mmol/l
1.61
70
627
151
1412
1.08
0.36
1.6
1.5
—
—
—
0
0
1059
10455
1.06
0.36
19.5
15.4
13.31
13.31
%
0.01
1049
10342
6
42
1.43
0.35
1.5
1.3
—
—
—
0
0
13
99
1.32
0.35
1.3
1.3
—
—
—
0
0
108
998
1.09
0.35
3.4
3.4
—
—
—
0
0
35
302
1.16
0.34
1.3
1.5
333.38
305.20
ug/g
0.36
16
162
6
86
0.70
0.33
1.0
1.6
—
—
—
0
0
15
119
1.26
0.32
1.2
2.1
—
—
—
0
0
134
1256
1.07
0.31
2.2
2.3
13.16
12.78
nmol/l
0.19
121
1161
24
283
0.85
0.31
1.4
1.1
—
—
—
0
0
431
4182
1.04
0.31
1.8
1.7
—
—
—
0
0
15
120
1.25
0.30
3.3
3.8
—
—
—
0
0
15
120
1.25
0.30
1.3
1.5
0.95
1.32
promille
—
10
98
527
5140
1.04
0.29
2.6
2.6
—
—
—
0
0
99
921
1.08
0.29
2.2
2.1
6.14
6.19
ph
0.21
69
580
16
130
1.23
0.28
1.8
1.6
0.52
0.49
e9/l
0.19
16
130
11
85
1.30
0.28
1.5
1.2
—
—
—
0
0
73
672
1.09
0.27
1.5
1.6
5.80
8.16
u/l
2.13
57
525
343
3325
1.04
0.26
2.0
1.8
—
—
—
0
0
26
299
0.87
0.26
4.0
3.5
35.58
1228.69
u/ml
1.29
26
256
15
123
1.22
0.25
1.0
1.3
—
—
nmol/l
—
0
0
9
75
1.20
0.25
2.6
2.5
47.67
55.05
umol/l
—
9
70
74
797
0.92
0.24
2.6
2.0
—
—
—
0
0
10
78
1.28
0.24
2.3
2.8
—
—
—
0
0
15
124
1.21
0.24
12.7
5.6
11.15
11.50
%
0.13
15
124
5
38
1.32
0.23
1.0
1.0
—
223.50
—
0
6
71
762
0.93
0.22
1.5
1.4
—
—
—
0
0
5
40
1.25
0.22
3.2
2.1
39.26
79.96
ug/l
—
5
40
54
585
0.92
0.21
1.8
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
4.6
—
7.15
—
0
10
12
98
1.23
0.21
1.4
1.2
—
—
—
0
0
55
594
0.92
0.20
1.9
1.6
—
—
—
0
0
17
145
1.17
0.20
4.4
2.0
—
—
—
0
0
12
99
1.21
0.19
1.2
1.5
12.21
10.94
umol/l
0.31
12
93
12
99
1.21
0.19
1.3
1.3
0.44
0.63
ratio
—
5
53
10
81
1.24
0.18
2.9
2.1
2.08
1.91
umol/l
—
10
75
41
376
1.09
0.18
2.5
2.1
3.77
4.01
iu/l
0.08
20
171
26
232
1.12
0.18
1.2
1.1
—
—
—
0
0
73
774
0.94
0.18
1.8
1.6
48.16
60.43
ug/l
2.48
64
666
17
195
0.87
0.17
2.2
2.7
246.21
114.39
ug/min
—
10
119
169
1631
1.04
0.17
1.3
1.3
—
—
—
0
0
7
63
1.11
0.17
1.1
1.0
—
—
—
0
0
8
69
1.16
0.16
2.9
2.3
33.63
28.10
umol/l
—
8
64
8
70
1.14
0.16
1.9
2.1
—
—
—
0
0
11
130
0.84
0.16
1.2
1.1
—
—
—
0
0
45
421
1.07
0.14
11.9
6.5
1.29
1.27
mg/l
0.05
40
390
54
572
0.94
0.14
1.7
1.5
1.18
1.28
mm
1.27
39
416
8
98
0.82
0.13
1.0
1.0
—
—
—
0
0
20
222
0.90
0.13
1.6
1.3
—
—
—
0
0
101
972
1.04
0.13
2.9
2.6
0.22
0.23
g/l
0.63
91
918
9
109
0.82
0.13
1.0
1.4
143.19
173.50
pmol/l
—
9
109
43
404
1.07
0.12
6.1
4.5
296.91
306.10
mg/l
0.02
22
206
28
260
1.08
0.11
1.4
1.1
—
—
—
0
0
13
115
1.13
0.10
1.0
1.0
—
—
—
0
0
5
46
1.09
0.09
1.6
2.0
37.80
29.02
%
—
5
46
6
55
1.09
0.09
3.0
1.9
13.62
16.35
umol/l
—
6
55
10
113
0.88
0.08
2.2
3.6
—
—
—
0
0
24
224
1.07
0.08
2.5
3.8
3.89
3.98
e9/l
0.11
24
224
7
66
1.06
0.08
1.1
1.1
232.39
184.78
iu/ml
—
7
66
14
127
1.10
0.08
1.0
1.2
21.03
41.85
mg/l
—
9
101
29
274
1.06
0.07
2.5
4.2
1.42
1.42
mmol/l
0.01
29
268
8
77
1.04
0.07
1.1
1.1
—
—
—
0
0
7
81
0.86
0.07
3.1
1.7
5.96
6.08
mmol/l
—
7
60
9
86
1.05
0.07
1.9
1.3
80.44
75.17
umol/l
—
9
86
22
234
0.94
0.06
3.6
3.2
—
—
—
0
0
9
102
0.88
0.06
3.4
1.9
—
—
—
0
0
16
148
1.08
0.06
1.2
1.3
—
0.58
—
0
5
13
120
1.08
0.05
1.2
1.1
—
—
—
0
0
166
1639
1.01
0.04
2.5
2.8
0.59
0.73
ug/l
1.82
82
885
29
278
1.04
0.04
1.3
1.2
—
—
—
0
0
16
170
0.94
0.04
2.6
2.9
23.92
24.57
nmol/l
0.08
16
163
141
1427
0.99
0.03
1.7
1.6
940.46
964.90
mu/l
0.12
121
1241
99
1003
0.99
0.03
2.1
2.2
—
—
—
0
0
124
1253
0.99
0.02
2.0
2.2
—
—
—
0
0
10
94
1.06
0.01
1.1
1.1
1672.10
1589.98
miu/ml
—
10
94
116
1167
0.99
0.00
2.0
2.2
—
—
—
0
0
16
166
0.96
0.00
2.4
1.5
—
—
—
0
0
16
166
0.96
0.00
2.4
1.5
—
—
—
0
0
16
166
0.96
0.00
2.4
1.5
—
—
—
0
0
16
166
0.96
0.00
2.4
1.5
—
—
—
0
0
21
216
0.97
0.00
1.8
1.6
—
—
—
0
0
44
446
0.99
0.00
1.9
1.7
—
—
—
0
0
54
534
1.01
0.00
2.6
2.9
—
—
—
0
0
14
136
1.03
0.00
2.6
1.9
—
—
—
0
0
21
206
1.02
0.00
4.0
3.3
1.67
2.34
mmol/l
0.68
15
130
30
304
0.99
0.00
2.4
3.4
56.03
56.70
%
0.12
30
304
28
278
1.01
0.00
1.4
1.4
59.71
135.96
pmol/l
1.00
28
269
77
771
1.00
0.00
2.1
1.6
—
—
—
0
0
132
1321
1.00
0.00
1.3
1.2
—
—
—
0
0
41
413
0.99
0.00
1.6
1.3
405.87
217.99
u/ml
1.13
23
236
126
1263
1.00
0.00
2.0
2.2
—
—
—
0
0
126
1257
1.00
0.00
1.9
2.2
—
—
—
0
0
27
265
1.02
0.00
3.1
3.0
1.53
4.17
index
1.03
15
147
24
235
1.02
0.00
2.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
385.24
—
0
9
0
7
0.00
0.00
0.0
2.9
—
40.43
—
0
7
8
81
0.99
0.00
2.5
2.5
115.38
149.73
nmol/l
—
8
73
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
0.15
—
0
7
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
1.66
—
0
5
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
129.00
—
0
5
7
70
1.00
-0.00
9.7
5.4
6.86
8.50
%
—
7
70
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
8048.17
—
0
6
125
1250
1.00
-0.00
1.9
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.34
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
18.30
—
0
8
0
6
0.00
-0.00
0.0
1.5
—
4.38
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
187.88
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
4.9
2.7
56.43
44.60
%
—
7
70
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
177.83
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
365.13
—
0
8
0
6
0.00
-0.00
0.0
1.5
—
1142.50
—
0
6

Mortality – FinRegistry

Association

Association between endpoint M13_JUVOSTEOCHONRHIP and mortality.

Females

Parameter HR [95% CI] p-value
M13_JUVOSTEOCHONRHIP 1.541 [1.25, 1.9] < 0.001
Birth year 0.991 [0.98, 1.0] 0.049

During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 5170 females with M13_JUVOSTEOCHONRHIP died.

Males

Parameter HR [95% CI] p-value
M13_JUVOSTEOCHONRHIP 1.025 [0.85, 1.23] 0.794
Birth year 0.99 [0.98, 1.0] 0.047

During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 6552 males with M13_JUVOSTEOCHONRHIP died.

Mortality risk

Mortality risk for people of age

years, who have M13_JUVOSTEOCHONRHIP.

N-year risk Females Males
1 0.154% 0.218%
5 0.888% 1.206%
10 2.037% 3.102%
15 3.735% 6.01%
20 6.754% 10.274%

Relationships between endpoints

Index endpoint: M13_JUVOSTEOCHONRHIP – Juvenile osteochondrosis

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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