No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditions
|
1838 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
408 |
4. Check minimum number of eventsNone |
408 |
5. Include endpointsNone |
408 |
6. Filter based on genotype QC (FinnGen only) |
375 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Open bite that required surgery (Lefort1 or BSSO)
based on the number of shared cases.
Similar with more cases:
- LeFortI or BSSO operation
- Open bite
- Anomalies of dental arch relationship, including avohilmo
- Dentofacial anomalies [including malocclusion]
- Gastrointestinal diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2132 | 1470 | 646 |
| Only index persons | 2100 | 1460 | 640 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 27.35 | 27.64 | 26.66 |
| Only index persons | 27.38 | 27.65 | 26.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 375 | 294 | 81 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.04 |
| Median age at first event (years) | 30.21 | 30.09 | 30.68 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 390
- Matched controls
- 3900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K07.24
ICD-10 Finland
Open bite
+∞
307.7
390
19
EB1MA
NOMESCO Finland
Cephalometry with X-ray
120.5
307.7
219
41
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
205.0
307.7
296
59
SBB10
NOMESCO Finland
Dental impressions
125.1
307.7
340
201
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
125.0
307.7
277
75
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
156.4
307.7
252
45
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
124.3
307.7
235
47
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
111.6
307.7
196
35
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
260.1
307.7
316
63
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
1083.9
307.7
287
10
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
198.7
307.7
211
23
SJC10
NOMESCO Finland
Orthodontic band in one tooth
241.1
307.7
265
34
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
116.1
307.7
213
40
K07.13
ICD-10 Finland
Retrognaty, mandibular
258.4
307.7
240
24
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
136.4
307.7
261
57
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
41.8
296.9
212
108
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
75.3
293.7
166
38
EEC05
NOMESCO Finland
Le Fort I osteotomy
2788.3
271.6
231
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
38.4
257.8
181
86
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
84.5
246.7
134
24
SAA04
NOMESCO Finland
Special examination of mouth
27.4
219.7
178
116
SJC40
NOMESCO Finland
Removal of fixed orthodontic appliance with at most 6 brackets
38.6
187.3
123
46
SXC05
NOMESCO Finland
Other oral or dental procedure
19.3
185.8
185
174
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
46.6
165.5
101
29
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
41.5
161.5
102
33
SJX20
NOMESCO Finland
Orthodontic treatment/control appointment
30.6
150.9
106
47
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
30.0
149.7
106
48
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
43.8
139.7
86
25
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
17.0
124.9
118
97
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
21.9
120.9
97
58
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
15.4
118.5
119
108
K07.60
ICD-10 Finland
Snapping jaw
11.7
112.1
143
184
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
10.4
109.3
160
245
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
9.0
107.2
208
439
SJB10
NOMESCO Finland
Fitting of removable appliance incl. patient instructions, demanding
39.1
90.9
57
17
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
39.1
90.9
57
17
K07.14
ICD-10 Finland
Retrognaty, maxillary
254.6
81.7
81
*
SJC00
NOMESCO Finland
Bondable bracket or other fixed attachement
206.8
81.6
82
5
K07.23
ICD-10 Finland
Deep bite
19.1
80.6
67
42
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
22.4
73.3
56
29
SXB00
NOMESCO Finland
Removal of sutures from oral mucosa
8.9
69.3
101
148
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
101.3
68.8
74
9
EBB10
NOMESCO Finland
Insertion of dental implant
30.5
68.3
46
17
SXC03
NOMESCO Finland
Other oral or dental procedure
36.1
65.8
42
13
WZC00
NOMESCO Finland
Treatment plan or consultation
6.2
65.7
272
1063
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
29.0
64.3
44
17
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
254.3
64.2
64
*
K07.10
ICD-10 Finland
Asymmetry of jaw
158.3
64.1
66
5
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
17.7
63.5
54
35
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
115.2
63.1
67
7
SAA03
NOMESCO Finland
Extended examination of mouth
6.9
62.8
308
1373
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
20.2
56.8
45
25
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
135.8
55.5
58
5
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
608.3
55.0
53
*
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
595.0
53.9
52
*
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
23.3
51.2
38
18
K07.20
ICD-10 Finland
Crossbite (anterior)(posterior)
76.3
47.5
53
8
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
14.3
42.3
40
31
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
4.4
42.0
273
1348
Z3229
NOMESCO Finland
Other healthcare associate professional
7.2
38.1
62
100
K07.22
ICD-10 Finland
Anomalies of dental arch relationship
105.0
35.4
38
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
6.8
35.3
60
101
SJE90
NOMESCO Finland
Orthodontic finishing
83.7
34.5
38
5
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
81.3
33.5
37
5
ZXE30
NOMESCO Finland
More than five and less than seven hours
8.6
33.5
45
58
ZXE20
NOMESCO Finland
More than three and less than five hours
5.0
32.0
78
184
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
119.8
31.2
33
*
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
173.8
31.2
32
*
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
10.3
31.1
36
38
K07.69
ICD-10 Finland
Dislocation of the jaw joint UNS
11.5
29.9
32
30
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
6.9
29.1
48
78
EDC30
NOMESCO Finland
Genioplasty
+∞
28.5
27
*
SJX00
NOMESCO Finland
Reparation of orthodontic appliance by dentist
26.2
27.6
38
16
K01.0
ICD-10 Finland
Embedded teeth
7.7
27.2
40
57
EEC02
NOMESCO Finland
Rapid expansion of maxilla
290.0
27.1
27
*
EBA10
NOMESCO Finland
Operative extraction of tooth
3.3
27.1
151
631
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
104.2
27.0
29
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
5.0
26.1
63
146
SJA02
NOMESCO Finland
Workplan for orthodontic treatment
100.3
26.0
28
*
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
8.9
23.4
30
36
EB1WA, ,
NOMESCO Finland
39.0
23.3
29
8
K07.21
ICD-10 Finland
Anomalies of dental arch relationship
69.4
23.1
26
*
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
8.3
22.9
31
40
EB1S1
NOMESCO Finland
Photography of teeth
66.6
22.1
25
*
EBB15
NOMESCO Finland
Insertion of dental implant abutment
41.2
22.0
27
7
EB1TW
NOMESCO Finland
3D modelling of dentition
53.2
21.4
25
5
ZXA10
NOMESCO Finland
Bilateral
3.4
21.4
92
323
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
20.3
127
553
WX725
NOMESCO Finland
Noninvasive ventilation
5.4
19.9
42
86
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
3.1
19.2
96
367
SPC20
NOMESCO Finland
Implant borne crown
40.6
18.8
23
6
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
28.3
18.0
24
9
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
14.1
17.2
29
22
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
5.8
17.0
32
59
SDA02
NOMESCO Finland
Periodontal treatment, brief
2.4
15.7
199
1187
K07.04
ICD-10 Finland
Macrognathism (mandibular)(maxillary)
88.7
15.7
17
*
K00.00
ICD-10 Finland
Hypodontia
11.5
15.2
28
26
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
4.4
15.1
40
99
EG1CG
NOMESCO Finland
Extensive MRI examination of mandibular joint with high intensity magnet
22.1
14.8
21
10
K07.4
ICD-10 Finland
Malocclusion, unspecified
6.7
14.7
24
38
K07.27
ICD-10 Finland
Anomalies of dental arch relationship
23.3
14.4
20
9
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
2.4
14.1
137
721
EEC00
NOMESCO Finland
Segmental osteotomy of maxilla
+∞
13.6
13
*
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
19.1
13.5
20
11
WX402
NOMESCO Finland
General anaesthesia
2.4
12.9
112
558
K07.61
ICD-10 Finland
Cracking jaw joint
4.4
12.8
33
80
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
12.9
12.8
22
18
OIKK, ,
NOMESCO Finland
5.3
12.6
26
52
SAA02
NOMESCO Finland
Basic examination of mouth
2.9
12.6
337
2671
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.7
12.3
41
120
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
48.2
12.0
14
*
TEG10
NOMESCO Finland
Injection of diagnostic or therapeutic substance into mandibular joint
67.0
11.7
13
*
EGC30
NOMESCO Finland
Prosthetic replacement of mandibular joint
+∞
11.5
11
*
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
123.5
11.5
12
*
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
20.8
11.2
16
8
SDA03
NOMESCO Finland
Periodontal treatment
2.0
10.8
205
1370
ZXX07
NOMESCO Finland
Extent of procedure, 7 units
61.7
10.7
12
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.3
10.6
28
69
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
112.9
10.5
11
*
TEG00
NOMESCO Finland
Punction of mandibular joint
112.9
10.5
11
*
M79.1
ICD-10 Finland
Myalgia
2.3
10.4
94
472
WX720
NOMESCO Finland
Own respiration
4.3
10.1
27
67
EG1AA
NOMESCO Finland
Mandibular joint X-ray examination
12.6
9.9
17
14
SPC10
NOMESCO Finland
Standard dental crown
11.0
9.9
18
17
WX704
NOMESCO Finland
Intubation
3.0
9.8
46
167
EFB50
NOMESCO Finland
Orthodontic procedure connected with ortognathic surgery
56.4
9.7
11
*
K07.01
ICD-10 Finland
Hyperplasia, hypoplasia mandibular
56.4
9.7
11
*
K06.00
ICD-10 Finland
Local gingivore traction
4.5
9.5
23
53
SPC08
NOMESCO Finland
Implant crown
30.9
9.5
12
*
ECA70
NOMESCO Finland
Regenerative periodontal surgery or gingival graft
22.3
9.4
13
6
K07.68
ICD-10 Finland
Other disorders of the jaw joint
9.9
9.4
18
19
SCA01
NOMESCO Finland
Preventive oral health care, short
2.0
9.3
166
1072
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
19.1
9.0
13
7
R4110
NOMESCO Finland
Physiotherapy
2.1
9.0
104
574
F45.8
ICD-10 Finland
Other somatoform disorders
2.5
8.6
59
261
EB1BD
NOMESCO Finland
Extensive cone beam CT of teeth and jaws (two quarters)
28.2
8.5
11
*
L01BA01
ATC
methotrexate; systemic
4.6
8.5
20
45
K07.12
ICD-10 Finland
Prognathism (mandibular)(maxillary)
92.0
8.4
9
*
QA9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head or neck, unspecified
92.0
8.4
9
*
SDA01
NOMESCO Finland
Periodontal treatment, very brief
1.9
8.2
147
940
SAA01
NOMESCO Finland
Simple examination of mouth
2.3
8.2
331
2766
K01.17
ICD-10 Finland
Retained molar with obstruction in the lower jaw
3.1
8.1
34
115
EAB10
NOMESCO Finland
Excision and repair of frenum of lip
34.1
8.1
10
*
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
34.1
8.1
10
*
K07.62
ICD-10 Finland
Habitual dislocation of the jaw joint
10.3
8.1
15
15
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
15.4
7.8
12
8
SPB10
NOMESCO Finland
Manufacture of a temporary crown to tooth at the dental office
15.4
7.8
12
8
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
15.4
7.8
12
8
Z96.5
ICD-10 Finland
Presence of tooth-root and mandibular implants
45.9
7.7
9
*
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
25.6
7.6
10
*
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
7.6
158
1055
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.6
7.5
25
73
SCB02
NOMESCO Finland
Instructions for self-performed oral hygiene
81.6
7.4
8
*
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
2.0
7.4
104
610
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
7.3
125
782
EEC99
NOMESCO Finland
Other reconstructive operations on maxilla
+∞
7.3
7
*
EBA12
NOMESCO Finland
Demanding operative extraction of tooth
2.9
7.3
34
123
SCA02
NOMESCO Finland
Preventive oral health care
2.2
7.3
67
336
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
6.9
52
239
OAB47, ,
SPAT
2.5
6.8
43
182
SPAT1324
SPAT
Screening procedure
1.9
6.8
102
611
N02AX02
ATC
tramadol; systemic, rectal
1.8
6.8
142
944
K07.33
ICD-10 Finland
Crowding of tooth or teeth
23.0
6.7
9
*
N02BE01
ATC
paracetamol; systemic, rectal
2.3
6.6
347
3025
J01CE02
ATC
phenoxymethylpenicillin; oral
1.9
6.6
309
2585
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
6.5
166
1165
AA3AD
NOMESCO Finland
CT of face
14.6
6.4
10
7
Z01.2
ICD-10 Finland
Dental examination
1.7
6.3
219
1667
ZYC01
NOMESCO Finland
Remote contact by phone
2.6
6.3
36
145
K07.29
ICD-10 Finland
Anomaly in the relationship between the tooth arches UNS
+∞
6.3
6
*
K07.63
ICD-10 Finland
Pain in the jaw joint UNS
3.6
6.2
20
57
Z50.1
ICD-10 Finland
Other physical therapy
3.6
6.2
20
57
ZXE40
NOMESCO Finland
More than seven and less than nine hours
6.2
6.1
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
221
1675
1.74
6.58
2.3
2.7
—
—
estimate
—
0
0
232
1894
1.56
4.31
3.3
3.3
0.00
0.02
estimate
0.80
57
399
183
1435
1.52
3.98
3.1
3.0
0.00
0.04
estimate
1.81
51
356
229
1886
1.52
3.92
3.3
3.3
0.02
3.66
estimate
0.49
60
412
376
3529
2.82
3.86
11.4
12.5
68.95
68.54
umol/l
0.24
376
3499
283
2463
1.54
3.56
4.3
3.7
8.05
8.44
mm/h
0.29
277
2338
223
1864
1.46
3.30
3.3
3.3
0.02
0.00
estimate
0.40
60
418
147
1136
1.47
3.27
2.7
2.7
0.00
0.02
estimate
1.34
52
348
14
49
2.93
3.22
1.4
1.4
—
—
—
0
0
19
80
2.45
3.11
3.6
9.8
1.24
1.54
%
0.86
19
71
333
3072
1.57
2.59
12.4
13.8
13.15
13.25
%
0.96
328
3046
42
257
1.71
2.55
4.2
4.8
—
—
—
0
0
309
2818
1.46
2.42
5.0
4.6
14.34
14.36
pmol/l
0.05
295
2665
50
328
1.60
2.34
1.4
1.6
1235.69
1156.29
nmol/l
0.30
42
254
34
201
1.76
2.34
1.5
1.4
9.08
9.36
u/l
0.05
27
165
128
1021
1.38
2.24
3.3
3.3
0.00
0.01
estimate
1.08
56
408
99
757
1.41
2.22
1.4
1.3
24.23
25.35
iu/ml
0.03
30
218
70
502
1.48
2.20
1.5
1.5
69841730.19
48559187.36
pmol/l
0.11
63
451
23
123
1.92
2.16
2.0
2.9
139.48
132.76
g/l
1.11
23
117
21
109
1.98
2.15
2.9
11.4
24.47
24.47
mmol/l
0.00
21
101
93
708
1.41
2.14
1.3
1.3
2.03
9.25
u/ml
3.30
41
295
344
3231
1.55
2.08
5.6
5.4
1.70
1.74
mu/l
0.30
332
3110
21
112
1.92
2.00
1.6
2.4
0.73
0.61
%
0.82
21
112
5
11
4.59
1.94
1.2
2.4
0.93
1.55
ug/l
—
5
11
17
85
2.05
1.93
1.5
1.3
264.12
307.79
mu/l
0.59
17
72
11
46
2.43
1.87
1.2
1.4
—
—
—
0
0
146
1218
1.32
1.85
1.8
1.8
—
—
—
0
0
231
2052
1.31
1.84
3.4
3.3
60.42
71.65
ug/l
1.33
224
1966
361
3446
1.64
1.81
10.4
11.3
18.97
19.18
mg/l
0.04
291
2726
43
292
1.53
1.77
1.2
1.3
248.84
251.65
miu/ml
0.02
22
158
41
276
1.54
1.75
2.0
1.8
—
—
—
0
0
6
148
0.40
1.67
1.2
3.1
5.15
5.08
kpa
—
6
141
35
231
1.57
1.64
3.0
2.5
12.73
11.75
nmol/l
0.26
30
219
31
205
1.56
1.45
3.0
10.8
4.97
5.14
kpa
0.39
31
195
31
205
1.56
1.45
3.0
10.8
14.86
13.69
kpa
0.47
31
196
9
39
2.34
1.44
4.6
1.5
25.62
24.49
nmol/l
—
9
33
30
198
1.56
1.42
2.8
11.2
1.69
0.83
mmol/l
0.46
23
163
43
307
1.45
1.42
1.6
1.6
294.79
285.49
mu/l
0.07
38
276
127
1078
1.26
1.35
2.3
2.2
—
—
—
0
0
15
83
1.84
1.33
2.3
3.2
26.21
25.04
mmol/l
0.85
15
77
34
235
1.49
1.32
1.4
1.6
54.94
54.60
ug/l
0.02
34
235
38
269
1.46
1.32
2.7
6.7
104.16
104.79
mmol/l
0.30
38
269
167
1466
1.24
1.32
2.3
2.5
77.71
72.72
nmol/l
1.48
160
1378
26
170
1.57
1.29
2.0
2.6
4.28
4.73
kpa
0.56
26
165
30
430
0.67
1.28
2.3
2.4
2.19
4.16
e6/l
0.94
15
191
32
452
0.68
1.27
2.1
2.3
0.64
0.77
e6/l
0.29
17
213
5
118
0.42
1.27
1.4
1.3
32.54
69.14
pmol/l
—
5
113
101
840
1.27
1.26
1.9
2.0
2.38
2.53
mg/l
0.43
92
729
29
196
1.52
1.26
2.0
3.0
1.97
1.70
mmol/l
0.29
29
169
10
49
2.07
1.23
1.3
1.7
0.66
0.50
e9/l
—
10
49
25
367
0.66
1.21
1.5
1.5
1.27
1.19
ratio
0.18
11
232
25
367
0.66
1.21
1.5
1.5
1.19
1.17
ratio
0.05
11
232
25
367
0.66
1.21
1.5
1.5
1.00
0.93
ratio
0.26
11
232
14
79
1.80
1.18
1.8
1.8
13.21
13.07
%
0.29
14
79
41
303
1.39
1.15
1.7
1.6
—
—
—
0
0
29
202
1.47
1.11
2.1
3.1
5.87
5.82
kpa
0.12
29
193
25
169
1.51
1.10
3.2
12.1
122.24
121.36
g/l
0.09
25
164
25
359
0.68
1.10
1.5
1.4
—
—
—
0
0
5
21
2.40
1.09
3.2
1.5
10.80
10.29
mmol/l
—
5
21
47
360
1.35
1.07
1.2
1.3
21.80
20.80
iu/l
0.07
40
311
306
2901
1.25
1.06
4.3
4.5
36.29
36.97
mmol/mol
0.86
295
2790
366
3556
1.48
1.05
9.9
9.4
25.35
25.88
u/l
0.20
358
3501
128
1116
1.22
1.04
1.3
1.3
1.80
1.71
u/ml
0.03
39
323
133
1171
1.21
0.97
2.5
2.4
—
—
—
0
0
9
50
1.82
0.97
1.3
2.0
—
1747.36
—
0
9
29
395
0.71
0.97
1.5
1.5
61.52
62.53
ug/l
0.05
22
341
97
828
1.23
0.96
3.4
3.1
1.02
1.02
kg/l
0.51
61
538
329
3155
1.27
0.96
7.5
9.7
94.73
96.21
ml/min/173m2
0.81
306
2830
93
791
1.23
0.95
1.7
1.7
0.66
0.81
mg/l
0.46
70
580
278
2621
1.21
0.95
2.9
3.0
27.04
34.19
u/l
2.97
267
2547
10
57
1.77
0.84
1.1
1.1
—
—
—
0
0
51
411
1.28
0.84
1.6
2.2
2.66
2.46
g/l
1.59
46
381
36
277
1.33
0.82
1.6
1.8
—
—
—
0
0
25
181
1.41
0.82
1.4
1.8
—
—
—
0
0
29
217
1.36
0.79
1.4
1.4
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
8.46
—
0
24
31
235
1.35
0.78
1.1
1.1
0.91
0.88
g/l
0.26
31
235
34
265
1.31
0.73
1.5
1.8
—
—
—
0
0
7
39
1.81
0.73
1.0
1.1
—
—
—
0
0
108
959
1.17
0.71
2.6
2.5
52.73
56.69
u/l
0.78
102
907
7
42
1.68
0.68
1.0
1.1
206.43
226.89
mg/l
—
7
36
30
232
1.32
0.68
1.0
1.1
1.61
1.55
g/l
0.50
30
232
5
92
0.54
0.68
3.2
2.0
—
—
—
0
0
104
924
1.17
0.67
2.0
2.7
14.73
26.20
ng/l
0.81
46
402
5
28
1.80
0.66
1.2
1.2
49.80
62.89
ug/l
—
5
28
5
28
1.80
0.66
1.2
1.1
93.80
117.68
pmol/l
—
5
28
19
137
1.41
0.66
1.1
1.1
0.22
3.95
u/ml
—
9
72
130
1179
1.15
0.65
1.7
1.8
93.59
97.32
pmol/l
0.52
77
647
8
50
1.61
0.61
1.3
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
1.9
—
10.07
—
0
15
0
20
0.00
0.60
0.0
1.7
—
—
—
0
0
51
432
1.21
0.57
1.5
1.4
—
—
—
0
0
10
65
1.55
0.56
1.3
1.5
—
—
—
0
0
34
279
1.24
0.52
1.3
1.3
—
—
—
0
0
335
3267
1.18
0.51
3.8
3.9
1.55
1.48
mmol/l
2.39
329
3138
30
243
1.25
0.51
2.1
2.6
—
—
—
0
0
11
75
1.48
0.51
1.3
1.5
—
—
—
0
0
336
3278
1.18
0.51
3.9
3.9
4.72
4.75
mmol/l
0.22
328
3159
46
391
1.20
0.51
1.8
1.9
—
—
—
0
0
26
207
1.27
0.51
1.2
1.6
—
—
—
0
0
187
1762
1.12
0.49
3.2
4.5
6.23
6.25
mmol/l
0.05
168
1583
205
1942
1.12
0.49
7.3
8.8
3.59
4.00
e9/l
2.42
187
1703
88
793
1.14
0.48
2.2
2.0
109.11
245.68
u/l
1.00
82
760
10
69
1.46
0.44
1.0
1.8
4.32
4.52
g/l
—
10
69
10
69
1.46
0.44
1.0
1.8
6.63
7.11
g/l
—
10
69
10
69
1.46
0.44
1.0
1.8
2.95
3.77
g/l
—
10
69
90
818
1.13
0.44
1.6
2.0
—
—
—
0
0
17
217
0.77
0.42
1.6
2.0
19.42
36.14
u/ml
0.88
17
207
5
32
1.57
0.42
1.6
1.5
—
—
—
0
0
5
33
1.52
0.41
1.0
1.1
1749.20
1660.33
miu/ml
—
5
33
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
7
102
0.68
0.40
1.0
1.2
229.43
228.49
u/ml
—
7
63
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
68
613
1.13
0.38
1.8
1.8
3.36
3.42
ratio
0.17
47
458
49
432
1.15
0.37
2.6
2.3
3073.11
6854.15
u/l
0.76
22
195
13
169
0.76
0.37
2.2
4.6
5.98
5.27
ug/l
—
5
132
15
116
1.30
0.37
1.0
1.1
1.69
1.81
u/ml
—
7
59
336
3295
1.14
0.37
4.1
4.2
2.77
2.84
mmol/l
0.83
330
3167
6
44
1.37
0.34
1.0
1.1
—
—
—
0
0
6
45
1.34
0.34
1.0
1.1
—
—
—
0
0
134
1266
1.09
0.32
4.0
6.2
1.21
1.22
mmol/l
0.31
119
1097
60
660
0.89
0.32
4.1
4.5
1.15
9.96
mg/mmol
5.28
37
439
7
96
0.72
0.31
3.0
2.2
—
—
—
0
0
313
3068
1.10
0.30
3.3
3.4
1.15
1.22
mmol/l
0.96
307
2929
8
108
0.74
0.29
1.0
1.3
—
—
—
0
0
45
403
1.13
0.29
1.2
1.3
82.63
137.53
u/ml
0.61
21
165
53
480
1.12
0.29
1.6
1.7
3.56
3.40
mmol/l
0.63
33
330
79
733
1.10
0.28
1.4
1.5
19.83
20.66
nmol/l
0.27
73
657
17
204
0.83
0.27
1.2
2.0
—
—
—
0
0
11
139
0.79
0.27
1.5
1.6
—
—
—
0
0
8
65
1.24
0.27
1.0
1.8
2.15
2.94
g/l
—
8
65
81
756
1.09
0.26
2.5
2.2
—
—
—
0
0
16
133
1.21
0.24
1.2
1.9
3.18
6.62
ug/l
1.19
16
121
11
87
1.27
0.24
1.2
1.3
361.94
332.25
ug/g
—
5
50
16
190
0.84
0.24
2.3
2.4
0.51
0.69
ug/l
—
6
88
16
190
0.84
0.24
1.1
1.2
—
—
—
0
0
5
38
1.32
0.23
1.4
1.2
—
—
—
0
0
5
38
1.32
0.23
1.4
1.2
—
—
—
0
0
5
38
1.32
0.23
1.4
1.2
—
—
—
0
0
17
200
0.84
0.23
1.4
1.4
—
—
—
0
0
49
450
1.10
0.22
2.1
2.9
6.80
765.33
ng/l
1.44
20
235
23
201
1.15
0.21
1.4
1.4
—
—
—
0
0
5
42
1.19
0.21
1.0
1.2
—
—
—
0
0
26
293
0.88
0.21
1.1
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
12
98
1.23
0.21
4.5
14.8
16.98
16.24
%
0.80
12
92
15
126
1.20
0.21
3.7
2.1
1.02
1.02
ratio
0.00
15
117
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
1053.15
—
0
13
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
6
48
1.25
0.20
1.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
95
998
0.94
0.20
1.7
1.6
—
—
—
0
0
16
137
1.18
0.19
1.2
1.1
4.32
5.40
eliau/ml
—
5
25
18
156
1.16
0.19
1.1
2.0
68.93
68.02
g/l
0.37
18
148
67
630
1.08
0.19
2.6
2.0
—
—
—
0
0
16
138
1.17
0.17
1.1
1.4
—
—
—
0
0
7
61
1.15
0.17
1.0
1.8
9.61
10.13
g/l
—
7
61
7
62
1.13
0.17
1.4
1.5
—
—
—
0
0
7
62
1.13
0.17
1.1
1.2
—
—
—
0
0
13
110
1.19
0.17
1.1
1.2
—
—
—
0
0
13
110
1.19
0.17
1.1
1.2
—
—
—
0
0
238
2332
1.05
0.17
6.8
7.1
68.91
72.92
u/l
1.21
226
2229
8
68
1.18
0.16
1.9
1.9
—
2752.00
—
0
5
8
71
1.13
0.16
1.1
1.5
—
—
—
0
0
71
674
1.07
0.16
1.6
1.6
1310.08
976.83
mu/l
0.67
60
579
158
1536
1.05
0.15
4.5
5.5
9.85
9.99
umol/l
0.10
152
1466
9
82
1.10
0.15
1.1
1.1
—
—
—
0
0
22
243
0.90
0.14
2.7
3.4
17.97
21.82
%
—
6
80
17
151
1.13
0.13
1.7
1.7
2.22
6.48
u/ml
—
5
45
9
107
0.84
0.13
1.2
1.5
—
—
—
0
0
60
571
1.06
0.13
1.6
1.8
1.26
1.36
%
0.91
52
515
11
127
0.86
0.12
1.2
1.3
—
—
—
0
0
5
46
1.09
0.09
1.0
2.4
4.22
5.68
pmol/l
—
5
46
45
471
0.95
0.09
2.1
2.6
238.55
463.19
ng/l
2.08
38
372
306
3036
1.04
0.08
4.0
4.0
—
—
—
0
0
5
64
0.78
0.08
1.6
2.2
1.82
3.42
index
—
5
31
14
127
1.11
0.08
1.6
2.8
24.36
24.31
mmol/l
0.06
14
127
114
1116
1.03
0.07
3.2
5.8
1.21
1.22
mmol/l
0.31
103
1039
8
75
1.07
0.07
1.1
1.2
—
—
—
0
0
305
3068
0.97
0.05
3.4
3.7
5.46
5.60
mmol/l
1.79
292
2901
13
141
0.92
0.05
2.7
2.2
2.21
4.41
iu/l
—
8
63
98
962
1.02
0.05
2.2
2.8
2.35
2.35
mmol/l
0.12
92
900
16
149
1.08
0.05
1.6
2.0
39.44
38.60
u/l
0.07
16
141
134
1324
1.02
0.04
1.9
1.8
1.24
1.36
mmol/l
1.11
123
1200
77
782
0.98
0.03
1.9
2.6
0.07
0.25
e6/l
3.01
60
541
11
103
1.07
0.02
1.0
1.3
—
54.05
—
0
14
10
107
0.93
0.02
1.2
1.3
—
—
—
0
0
15
144
1.04
0.00
1.8
2.3
5.41
5.10
umol/l
—
9
110
13
132
0.98
0.00
1.0
1.3
—
20.35
—
0
10
14
141
0.99
0.00
2.6
6.5
25.23
24.83
mmol/l
0.22
14
141
16
159
1.01
0.00
1.2
1.3
3.26
3.29
ug/l
0.01
16
146
21
209
1.01
0.00
1.6
2.2
89.50
79.92
ml/min/173m2
1.04
12
88
12
124
0.97
0.00
1.0
1.3
—
2.38
—
0
15
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
21.40
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
7.77
—
0
5
0
5
0.00
0.00
0.0
1.2
—
8.20
—
0
5
6
68
0.88
-0.00
3.3
1.8
32.33
184.00
ug/l
—
6
63
0
6
0.00
-0.00
0.0
1.0
—
0.02
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
1.20
—
0
7
7
74
0.94
-0.00
1.3
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.7
—
4.44
—
0
9
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
19
190
1.00
-0.00
1.3
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
9.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.8
—
—
—
0
0
7
72
0.97
-0.00
1.1
1.5
—
—
—
0
0
9
99
0.91
-0.00
1.1
1.1
—
—
—
0
0
8
82
0.98
-0.00
1.1
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.6
—
28.11
—
0
9
0
9
0.00
-0.00
0.0
4.7
—
12.32
—
0
9
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
7
76
0.92
-0.00
1.1
3.1
—
1112.00
—
0
5
9
92
0.98
-0.00
1.0
1.4
—
1.07
—
0
8
6
67
0.89
-0.00
1.7
1.6
1.29
0.97
ug/l
—
6
60
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_OPEN_BITE_SURGERY and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have K11_OPEN_BITE_SURGERY.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: K11_OPEN_BITE_SURGERY – Open bite that required surgery (Lefort1 or BSSO)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data