Open bite

K11_OPEN_BITE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 K07.24
  • Hospital discharge: ICD-10 K07.24
  • Cause of death: ICD-10 K07.24

3 out of 7 registries used, show all original rules.

2555

4. Check minimum number of events

None

2555

5. Include endpoints

None

2555

6. Filter based on genotype QC (FinnGen only)

2309

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF10

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 33503 19782 13652
Only index persons 28156 16874 11282
Unadjusted period prevalence (%)
Whole population 0.49 0.57 0.38
Only index persons 0.54 0.62 0.43
Median age at first event (years)
Whole population 12.86 13.55 11.78
Only index persons 14.52 15.12 13.62

-FinnGen-

Key figures

All Female Male
Number of individuals 2309 1746 563
Unadjusted period prevalence (%) 0.53 0.62 0.26
Median age at first event (years) 31.97 32.53 30.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2431
Matched controls
24310
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
7.2
321.6
558
969
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
6.9
314.4
568
1027
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
9.2
307.7
529
713
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
10.0
307.7
402
472
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
8.7
307.7
660
994
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
6.5
307.7
995
2339
SBB10
NOMESCO Finland
Dental impressions
10.1
307.7
1236
2260
SJC10
NOMESCO Finland
Orthodontic band in one tooth
9.3
307.7
565
766
K07.24
ICD-10 Finland
Open bite
+∞
307.7
2431
*
K07.60
ICD-10 Finland
Snapping jaw
8.6
307.7
642
971
EEC05
NOMESCO Finland
Le Fort I osteotomy
146.5
307.7
238
18
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
9.6
307.7
683
954
K07.13
ICD-10 Finland
Retrognaty, mandibular
25.0
307.7
511
256
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
8.3
307.7
557
839
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
13.0
307.7
530
509
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
11.6
307.7
702
821
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
12.7
307.7
520
509
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
7.6
307.7
779
1415
EB1MA
NOMESCO Finland
Cephalometry with X-ray
11.7
307.7
733
867
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
56.0
307.7
300
61
SAA04
NOMESCO Finland
Special examination of mouth
7.2
307.7
627
1125
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
17.5
279.2
235
148
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
7.6
274.0
433
675
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
8.1
273.9
406
589
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
5.5
261.8
623
1444
K07.14
ICD-10 Finland
Retrognaty, maxillary
30.3
258.7
172
61
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
23.8
257.0
187
85
SAA03
NOMESCO Finland
Extended examination of mouth
4.4
235.2
1813
9725
SXC05
NOMESCO Finland
Other oral or dental procedure
4.5
224.9
692
1959
SJC00
NOMESCO Finland
Bondable bracket or other fixed attachement
43.6
220.7
132
32
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
66.4
207.7
114
18
K07.10
ICD-10 Finland
Asymmetry of jaw
34.3
203.9
130
40
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
6.7
185.7
317
529
K07.21
ICD-10 Finland
Anomalies of dental arch relationship
27.0
175.8
121
47
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
4.8
170.4
437
1055
WZC00
NOMESCO Finland
Treatment plan or consultation
3.2
166.7
1440
7640
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
5.1
164.5
391
885
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
4.6
157.1
422
1054
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
5.5
150.3
319
652
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
61.3
149.1
83
14
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
28.6
147.0
99
36
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
20.7
145.4
111
56
SJC40
NOMESCO Finland
Removal of fixed orthodontic appliance with at most 6 brackets
4.6
143.7
380
934
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
29.8
138.5
92
32
SJX20
NOMESCO Finland
Orthodontic treatment/control appointment
4.9
138.0
334
763
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.9
137.6
1516
8847
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
13.0
134.3
131
106
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
27.5
124.5
85
32
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
3.3
123.7
567
2031
EB1TW
NOMESCO Finland
3D modelling of dentition
37.3
122.4
76
21
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
4.4
121.4
341
874
K07.69
ICD-10 Finland
Dislocation of the jaw joint UNS
8.6
108.1
141
172
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
7.7
106.7
153
209
K07.20
ICD-10 Finland
Crossbite (anterior)(posterior)
6.1
99.4
181
318
EG1CG
NOMESCO Finland
Extensive MRI examination of mandibular joint with high intensity magnet
16.8
98.9
83
51
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
11.5
98.3
103
93
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
3.4
93.5
379
1243
EBB10
NOMESCO Finland
Insertion of dental implant
9.3
87.5
107
120
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
7.4
86.8
129
183
K07.22
ICD-10 Finland
Anomalies of dental arch relationship
7.0
86.1
134
200
EB1S1
NOMESCO Finland
Photography of teeth
10.0
85.6
99
103
F45.8
ICD-10 Finland
Other somatoform disorders
3.1
81.0
391
1418
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.5
75.1
285
891
SJA02
NOMESCO Finland
Workplan for orthodontic treatment
24.1
72.7
52
22
SXC03
NOMESCO Finland
Other oral or dental procedure
11.7
72.6
75
66
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
22.6
72.2
53
24
SJB10
NOMESCO Finland
Fitting of removable appliance incl. patient instructions, demanding
4.9
68.6
156
334
K07.61
ICD-10 Finland
Cracking jaw joint
4.5
66.7
169
395
EB1WA, ,
NOMESCO Finland
12.6
66.0
65
53
SDA02
NOMESCO Finland
Periodontal treatment, brief
2.0
63.3
1145
7373
SAA02
NOMESCO Finland
Basic examination of mouth
2.7
60.3
2133
17572
EG1AA
NOMESCO Finland
Mandibular joint X-ray examination
12.3
60.1
60
50
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
10.7
59.6
65
62
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
3.9
58.9
180
484
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
7.1
58.6
89
129
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
3.2
58.1
248
830
SXB00
NOMESCO Finland
Removal of sutures from oral mucosa
3.2
58.0
257
879
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
10.2
57.7
65
65
SJE90
NOMESCO Finland
Orthodontic finishing
8.7
57.3
73
86
EBB15
NOMESCO Finland
Insertion of dental implant abutment
10.4
56.5
63
62
M79.1
ICD-10 Finland
Myalgia
2.3
56.1
529
2633
SDA03
NOMESCO Finland
Periodontal treatment
1.9
55.4
1203
8132
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.8
55.4
177
491
K07.4
ICD-10 Finland
Malocclusion, unspecified
4.9
54.8
125
268
K07.04
ICD-10 Finland
Macrognathism (mandibular)(maxillary)
20.8
54.0
41
20
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
5.7
52.8
101
185
K07.62
ICD-10 Finland
Habitual dislocation of the jaw joint
7.6
51.4
73
98
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
7.3
51.4
76
107
Z3229
NOMESCO Finland
Other healthcare associate professional
3.0
50.7
251
913
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.3
50.4
201
644
SJX00
NOMESCO Finland
Reparation of orthodontic appliance by dentist
5.9
47.5
87
153
SPC20
NOMESCO Finland
Implant borne crown
9.1
45.5
56
63
TEG10
NOMESCO Finland
Injection of diagnostic or therapeutic substance into mandibular joint
17.9
45.5
37
21
K07.12
ICD-10 Finland
Prognathism (mandibular)(maxillary)
18.3
44.7
36
20
K00.00
ICD-10 Finland
Hypodontia
4.2
42.3
117
292
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
3.1
42.2
187
637
K07.68
ICD-10 Finland
Other disorders of the jaw joint
6.9
40.4
63
94
K07.26
ICD-10 Finland
Anomalies of dental arch relationship
14.0
39.1
36
26
EEC02
NOMESCO Finland
Rapid expansion of maxilla
198.1
37.9
39
*
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
37.7
907
6115
K07.63
ICD-10 Finland
Pain in the jaw joint UNS
4.0
37.2
107
275
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
6.7
37.0
59
90
SAA01
NOMESCO Finland
Simple examination of mouth
2.0
36.9
2030
17329
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
8.0
36.3
49
62
SDA04
NOMESCO Finland
Demanding periodontal treatment
1.8
36.2
834
5539
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
6.7
35.8
57
87
WZA90
NOMESCO Finland
Other medical or dental certificate
1.8
34.9
752
4886
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
6.0
34.8
62
106
Z01.2
ICD-10 Finland
Dental examination
1.7
34.6
1459
11380
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
8.9
34.6
43
49
K03.64
ICD-10 Finland
Dental calculus supragingival
1.7
34.5
1112
8075
K03.00
ICD-10 Finland
Approximal wear
2.3
33.7
269
1230
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
4.1
33.0
93
235
K01.0
ICD-10 Finland
Embedded teeth
3.2
32.1
129
414
K07.55
ICD-10 Finland
Malocclusion caused by tongue, lip and finger habits
11.5
31.8
33
29
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.3
31.0
264
1238
K07.23
ICD-10 Finland
Deep bite
2.5
29.9
203
862
EDC30
NOMESCO Finland
Genioplasty
156.9
29.7
31
*
SPC10
NOMESCO Finland
Standard dental crown
5.7
29.1
54
96
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.7
29.1
631
4071
EMAK, ,
NOMESCO Finland
2.9
28.7
138
491
L01BA01
ATC
methotrexate; systemic
3.4
28.4
103
310
A07EC01
ATC
sulfasalazine; oral, rectal
2.5
28.4
192
813
P01BA02
ATC
hydroxychloroquine; oral
2.5
28.1
192
817
K03.66
ICD-10 Finland
Tooth plaque
2.1
26.7
292
1508
K05.30
ICD-10 Finland
Periodontitis complex
2.1
26.1
287
1486
G47.3
ICD-10 Finland
Sleep apnoea
1.8
25.7
409
2399
OIKK, ,
NOMESCO Finland
2.2
25.7
226
1073
G47.8
ICD-10 Finland
Other sleep disorders
3.0
24.7
115
402
L04AX03
ATC
methotrexate; systemic
2.1
24.0
239
1190
SPB10
NOMESCO Finland
Manufacture of a temporary crown to tooth at the dental office
7.5
23.8
34
46
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
23.5
180
806
ZXA10
NOMESCO Finland
Bilateral
1.8
23.1
362
2108
R06.5
ICD-10 Finland
Mouth breathing
2.1
22.9
223
1100
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
1.7
22.5
508
3285
SCA01
NOMESCO Finland
Preventive oral health care, short
1.5
22.4
1162
9124
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
2.9
22.3
110
397
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
2.9
21.9
106
379
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
21.6
249
1307
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
21.4
504
3289
Z96.5
ICD-10 Finland
Presence of tooth-root and mandibular implants
23.3
21.3
30
13
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.7
21.2
112
420
TEG00
NOMESCO Finland
Punction of mandibular joint
24.4
20.8
29
12
EGC30
NOMESCO Finland
Prosthetic replacement of mandibular joint
37.5
20.8
26
7
D19
ICPC
Teeth/gum symptom/complaint
1.5
20.8
906
6823
S03.0
ICD-10 Finland
Dislocation of jaw
5.6
20.6
39
71
SPA41
NOMESCO Finland
Precision impression for fixed dental prosthesis
3.8
20.5
63
170
SDA01
NOMESCO Finland
Periodontal treatment, very brief
1.5
20.2
937
7134
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.2
20.2
184
884
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
2.4
20.0
135
570
K06.00
ICD-10 Finland
Local gingivore traction
3.2
20.0
79
251
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.3
20.0
159
723
EBA10
NOMESCO Finland
Operative extraction of tooth
1.6
19.5
543
3688
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
3.0
19.2
86
295
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.5
19.1
1584
13496
L88
ICPC
Rheumatoid/seropositive arthritis
2.7
18.6
101
384
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
6.5
18.4
30
47
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
18.3
226
1215
K07.29
ICD-10 Finland
Anomaly in the relationship between the tooth arches UNS
44.3
18.2
22
5
ZXX07
NOMESCO Finland
Extent of procedure, 7 units
67.1
17.7
20
*
D82
ICPC
Teeth/gum disease
1.5
17.6
1097
8783
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
17.5
552
3845
G50.1
ICD-10 Finland
Atypical facial pain
3.8
17.4
52
138
ECA70
NOMESCO Finland
Regenerative periodontal surgery or gingival graft
12.6
17.1
30
24
L04AA01
ATC
[U] ciclosporin
4.6
17.1
40
88
SPA30
NOMESCO Finland
Grinding of a single crown and bridge pillar or a single post and crown
4.2
17.0
45
109
ECA50
NOMESCO Finland
Periodontal flap surgery
6.3
16.7
28
45
K07.6
ICD-10 Finland
Temporomandibular joint disorders
4.2
16.7
44
106
QA9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head or neck, unspecified
20.2
16.4
24
12
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
16.2
388
2527
K05.10
ICD-10 Finland
Gingivitis (chronic) NOS
1.5
16.1
526
3687
KAY20, ,
NOMESCO Finland
2.3
16.0
123
551
EGA05
NOMESCO Finland
Rinsing of mandibular joint
28.8
15.2
20
7
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
17.8
15.1
23
13
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.2
15.1
58
182
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.5
15.0
93
378
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
1.5
14.8
495
3480
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
13.3
14.7
25
19
ZYC01
NOMESCO Finland
Remote contact by phone
1.9
14.6
179
958
M01AH01
ATC
celecoxib; oral
1.8
14.2
241
1428
K07.27
ICD-10 Finland
Anomalies of dental arch relationship
2.8
14.2
71
259
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.4
14.2
102
444
K05.31
ICD-10 Finland
Periodontitis pronounced
1.9
13.8
167
891
EG1DG
NOMESCO Finland
Very extensive MRI examination of mandibular joint with high intensity magnet
13.6
13.7
23
17
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
3.0
13.6
61
210
EFB50
NOMESCO Finland
Orthodontic procedure connected with ortognathic surgery
34.2
13.5
17
5
R5140
NOMESCO Finland
Monitoring the use of the aid
1.9
13.4
167
900
H02AB09
ATC
hydrocortisone; systemic
2.5
13.1
84
347
K07.28
ICD-10 Finland
Another anomaly in the relationship between the dental arches
11.0
13.0
24
22
SDA05
NOMESCO Finland
Very demanding periodontal treatment
1.8
12.9
205
1191
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
13.0
12.9
22
17
SJC20
NOMESCO Finland
Extraoral traction appliance arrangement incl. patient instructions
3.3
12.9
48
148
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.8
12.8
205
1194
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.2
12.6
112
533
EBA12
NOMESCO Finland
Demanding operative extraction of tooth
2.0
12.5
136
699
EEC00
NOMESCO Finland
Segmental osteotomy of maxilla
130.7
12.4
13
*
EG1AD
NOMESCO Finland
CT of mandipular joint
130.7
12.4
13
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.1
12.4
123
611
SDE04
NOMESCO Finland
Periodontal treatment by dental hygienist, very extensive
1.8
12.4
184
1049
WX725
NOMESCO Finland
Noninvasive ventilation
2.1
12.3
114
553
EGA00
NOMESCO Finland
Arthroscopy of mandibular joint
10.5
12.2
23
22
OIKAL, ,
NOMESCO Finland
2.4
12.2
80
335
SCA02
NOMESCO Finland
Preventive oral health care
1.5
12.1
482
3494
R4110
NOMESCO Finland
Physiotherapy
1.5
12.1
516
3792
R51.81
ICD-10 Finland
Facial pain NOS
2.7
12.1
64
241
KMAK, ,
NOMESCO Finland
1.4
12.1
1139
9570
SPB20
NOMESCO Finland
Temporary bridge
11.1
12.0
22
20
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
10.1
12.0
23
23
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
2.4
11.9
84
363
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
11.9
437
3118
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
11.6
449
3234
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
2.4
11.6
78
330
K02.0
ICD-10 Finland
Caries limited to enamel
1.4
11.6
747
5902
EBW99
NOMESCO Finland
Other operation on tooth
23.0
11.6
16
7
SPAT1324
SPAT
Screening procedure
1.5
11.4
443
3193
M01CB01
ATC
sodium aurothiomalate; parenteral
4.7
11.4
26
56
SFA10
NOMESCO Finland
One-surface restoration
1.3
11.3
1429
12504
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
3.2
11.2
43
135
K03.29
ICD-10 Finland
Erosion of teeth occupational
2.7
11.2
57
211
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
11.1
1810
16448
RK220, ,
NOMESCO Finland
5.3
11.1
22
42
OIKH, ,
NOMESCO Finland
1.9
11.1
137
737
K07.01
ICD-10 Finland
Hyperplasia, hypoplasia mandibular
13.9
11.0
18
13
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
2.8
10.9
53
191
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.1
10.9
108
538
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
3.2
10.9
43
138
SPC08
NOMESCO Finland
Implant crown
5.6
10.7
20
36
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
3.3
10.7
39
119
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
3.9
10.6
30
77
EB4VA, ,
NOMESCO Finland
1.4
10.5
474
3511
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.3
10.5
1254
10826
ECA20
NOMESCO Finland
Biopsy of gingiva
4.7
10.5
24
52
N03AX16
ATC
[U] pregabalin
1.5
10.4
343
2389
A02BC03
ATC
lansoprazole; oral
1.5
10.4
386
2757
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.7
10.3
208
1291
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
10.3
394
2827
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.4
10.3
430
3138
SCA03
NOMESCO Finland
Preventive oral health care, extensive
1.7
10.3
176
1046
ZXX05
NOMESCO Finland
Extent of procedure, 5 units
8.8
10.3
21
24
ZXE40
NOMESCO Finland
More than seven and less than nine hours
2.7
10.1
51
188
L04AA13
ATC
[U] leflunomide
2.8
10.1
49
177
K02.3
ICD-10 Finland
Arrested dental caries
2.3
10.0
74
327
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
10.0
378
2704
Z3226
NOMESCO Finland
Physiotherapist
1.5
10.0
365
2594
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
10.0
645
5074
SJB30
NOMESCO Finland
Extraoral traction arrangements and operation instruction, removable appliance
2.5
9.8
59
238
K01.16
ICD-10 Finland
Retained molar with obstruction in the upper jaw
2.2
9.8
79
363
M13.9
ICD-10 Finland
Arthritis, unspecified
1.8
9.7
149
857
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.7
9.7
170
1017
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.6
9.6
203
1275
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
5.3
9.6
19
36
-1, ,
NOMESCO Finland
1.3
9.6
993
8362
EBA00
NOMESCO Finland
Extraction of tooth
1.3
9.6
971
8152
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
3.8
9.6
29
78
HMAK, ,
NOMESCO Finland
1.6
9.6
259
1727
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.2
9.5
75
341
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
1.6
9.5
251
1667
SPAT1301
SPAT
No procedures
1.4
9.5
639
5056
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
9.4
716
5768
SAALT, ,
NOMESCO Finland
2.3
9.4
69
305
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
3.6
9.4
30
84
XX2XT
NOMESCO Finland
Other injection with other radiological guidance
5.2
9.4
19
37
L04AB01
ATC
etanercept; parenteral
2.6
9.3
51
196
SPAT1229
SPAT
Assessment of need for aid
2.1
9.2
81
386
K07.33
ICD-10 Finland
Crowding of tooth or teeth
4.2
9.2
24
58
Z3231
NOMESCO Finland
Registered nurse
1.4
9.1
565
4409
K07.35
ICD-10 Finland
Impacted or embedded teeth with abnormal position of such teeth or adjacent teeth
2.7
9.1
47
176
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.6
9.1
204
1303
SFB40
NOMESCO Finland
Filling of four surfaces reproduced outside mouth
4.6
9.1
21
46
A02BC05
ATC
esomeprazole; systemic
1.3
9.0
668
5352
SPA02
NOMESCO Finland
Preparation for dental prosthetics
2.5
9.0
56
230
127
Kela drug reimbursment
Transplant complication
2.9
9.0
42
149
EG1CM
NOMESCO Finland
Mandibular joint extensive MRI examination with 3 Tesla magnet
18.7
8.9
13
7
K11.71
ICD-10 Finland
Xerostomy (dry mouth)
4.2
8.9
23
55
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
8.9
601
4748
N03AX12
ATC
[U] gabapentin; oral
1.5
8.9
244
1633
SXB10
NOMESCO Finland
Removal of attachments and rails from moth
4.7
8.8
20
43
L07
ICPC
Jaw symptom/complaint
2.4
8.8
61
263
EB1BD
NOMESCO Finland
Extensive cone beam CT of teeth and jaws (two quarters)
9.5
8.8
17
18
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.4
8.7
351
2540
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
8.7
713
5793
SPC25
NOMESCO Finland
Other demanding attachment of prosthodontic crown
14.1
8.7
14
10
WYA10
NOMESCO Finland
Emergency care or similar visit
1.6
8.7
198
1269
M25.5
ICD-10 Finland
Pain in joint
1.3
8.6
707
5742
L04AB06
ATC
golimumab; parenteral
3.5
8.6
29
84
K06.18
ICD-10 Finland
Another gingival hyperplasia
4.0
8.6
24
61
ZXX03
NOMESCO Finland
Extent of procedure, 3 units
4.6
8.6
20
44
XKD00
NOMESCO Finland
Uroflowmetry
1.8
8.6
124
702
L04AB04
ATC
adalimumab; parenteral
2.2
8.5
69
319
YEA05
NOMESCO Finland
Excision of gingival or connective tissue for transplantation
20.1
8.5
12
6
Z2445
NOMESCO Finland
Psychologist
1.7
8.4
159
971
EEW99
NOMESCO Finland
Other operation on maxilla
90.4
8.4
9
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
1.6
8.4
202
1312
J34.3
ICD-10 Finland
Hypertrophy of nasal turbinates
2.4
8.3
55
232
K06.19
ICD-10 Finland
Gingival hyperplasia UNS
4.0
8.3
23
58
SPAT1263
SPAT
Sampling
1.3
8.3
941
7983
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
2.9
8.2
38
134
Z50.1
ICD-10 Finland
Other physical therapy
2.0
8.2
82
411
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
8.2
472
3635
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
8.1
1091
9443
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
1.4
8.1
428
3245
-2, ,
ICD-10 Finland
1.9
8.1
95
503
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.5
8.0
292
2072
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
1.6
7.9
206
1361
L04AX01
ATC
azathioprine; systemic
1.9
7.9
96
515
J34.2
ICD-10 Finland
Deviated nasal septum
1.9
7.9
96
515
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.4
7.9
454
3492
SAE02, ,
NOMESCO Finland
2.6
7.8
45
178
ND1AA
NOMESCO Finland
Wrist X-ray examination
1.7
7.8
143
868
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.6
7.8
175
1119
WX704
NOMESCO Finland
Intubation
1.7
7.8
153
946
J02AC01
ATC
fluconazole; systemic
1.3
7.8
848
7141
A02BC01
ATC
omeprazole; systemic
1.4
7.8
447
3438
L04AB05
ATC
certolizumab pegol; parenteral
3.7
7.7
24
66
EGC10
NOMESCO Finland
Arthroplasty of mandibular joint without graft
15.1
7.7
12
8
XF404
NOMESCO Finland
Ambulatory ECG
1.8
7.7
120
696
RD210, ,
NOMESCO Finland
2.1
7.6
72
353
FM2CE, ,
NOMESCO Finland
2.3
7.6
56
249
EEC99
NOMESCO Finland
Other reconstructive operations on maxilla
25.1
7.6
10
*
M03AX01
ATC
botulinum toxin; parenteral
2.4
7.6
52
224
SAE03, ,
NOMESCO Finland
4.1
7.5
20
49
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.7
7.5
135
814
K05.18
ICD-10 Finland
Chronic gingivitis
1.5
7.5
201
1338
L28
ICPC
Limited function/disability (L)
1.5
7.5
229
1570
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
2.3
7.4
56
251
WVA30
NOMESCO Finland
Intramuscular and subcutaneous injection
4.4
7.4
18
41
EAB10
NOMESCO Finland
Excision and repair of frenum of lip
4.4
7.4
18
41
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.5
7.4
271
1924
R01AD58
ATC
fluticasone, combinations; nasal
1.3
7.4
661
5414
H93.1
ICD-10 Finland
Tinnitus
1.8
7.4
117
682
AA1AD
NOMESCO Finland
CT of head and brain
1.4
7.4
344
2554
R01AD08
ATC
fluticasone; nasal
1.3
7.4
596
4817
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
3.8
7.4
22
59
H02AB06
ATC
prednisolone; systemic
1.3
7.3
836
7068
SPAT1153
SPAT
Removal of sutures
1.4
7.3
445
3450
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.7
7.3
143
883
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
15.8
7.2
11
7
K06.10
ICD-10 Finland
Gingival fibromatosis
15.8
7.2
11
7
ECA55
NOMESCO Finland
Complicated periodontal flap surgery
5.8
7.2
19
33
UKC02
NOMESCO Finland
Cystoscopy
1.6
7.2
149
933
OIKTA, ,
NOMESCO Finland
3.9
7.2
20
51
RL140, ,
NOMESCO Finland
3.6
7.1
23
65
OIKOV, ,
NOMESCO Finland
20.1
7.1
10
5
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.0
7.1
71
356
F82
ICD-10 Finland
Specific developmental disorder of motor function
2.6
7.1
39
151
XX9XE
NOMESCO Finland
Other ultrasound examination
3.5
7.1
24
70
WX720
NOMESCO Finland
Own respiration
1.9
7.1
83
440
M01AE02
ATC
naproxen; oral, rectal
1.3
7.1
1364
12247
ECW06
NOMESCO Finland
Insertion of mini-implant or miniscrew
12.1
7.1
12
10
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
7.0
734
6127
L04AA17
ATC
[U] adalimumab
8.8
7.0
14
16
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
7.0
740
6186
Z2446
NOMESCO Finland
Social worker
1.5
7.0
189
1260
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
3.2
7.0
26
81
SPAT1310
SPAT
Counselling related to known health issue
1.3
6.9
705
5865
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
1.6
6.9
140
872
H20.1
ICD-10 Finland
Chronic iridocyclitis
3.0
6.9
29
97
M50.3
ICD-10 Finland
Other cervical disc degeneration
2.7
6.9
36
136
602
Kela drug reimbursment
Children's severe malnutrition
2.6
6.9
38
148
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
2.0
6.9
72
368
R01AD09
ATC
mometasone; nasal
1.3
6.9
1044
9113
R1250
NOMESCO Finland
Evaluation of functional capability
2.3
6.8
51
228
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.4
6.8
360
2726
P85
ICPC
Mental retardation
3.4
6.8
24
72
DFF00
NOMESCO Finland
Pure tone audiometry
1.6
6.8
137
852
NDG30
NOMESCO Finland
Fusion of wrist, total
6.7
6.8
16
24
RK110, ,
NOMESCO Finland
3.8
6.8
20
53
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
1.7
6.8
129
791
L29.0
ICD-10 Finland
Pruritus ani
3.0
6.8
28
93
C05AA08
ATC
fluocortolone; rectal, topical
1.6
6.8
171
1124
H04.10
ICD-10 Finland
Dry eye syndrome
1.5
6.8
218
1510
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
1.6
6.8
155
996
K07.08
ICD-10 Finland
Other specified anomaly in the size of the cores
40.2
6.8
8
*
K07.32
ICD-10 Finland
Displacement of tooth or teeth
4.3
6.7
17
40
SPC30
NOMESCO Finland
Surface-retained bridge
4.3
6.7
17
40
UJF32
NOMESCO Finland
Coloscopy
1.4
6.7
329
2461
A11CC03
ATC
alfacalcidol; systemic
2.4
6.7
43
180
SPA40
NOMESCO Finland
Precision impression for dental prosthesis
7.2
6.7
15
21
OIKON, ,
NOMESCO Finland
3.2
6.7
25
78
EEC45
NOMESCO Finland
Reconstruction of maxilla using bone graft
22.6
6.7
9
*
EB1BA
NOMESCO Finland
Extensive intraoral X-ray examination
7.8
6.6
14
18
K07.58
ICD-10 Finland
Other abnormal function of teeth and jaws
2.7
6.6
33
122
POLI, ,
NOMESCO Finland
12.3
6.6
11
9
HAMTE, ,
NOMESCO Finland
3.3
6.6
24
74
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
6.5
493
3938
ENC30
NOMESCO Finland
Plastic operation of pharynx
3.7
6.5
20
55
L13
ICPC
Hip symptom/complaint
1.4
6.5
270
1965
K07
ICD-10 Finland
Dentofacial anomalies [including malocclusion]
3.1
6.4
25
80
XA800
NOMESCO Finland
Neuropsychological investigation
1.7
6.4
108
642
B03XA01
ATC
erythropoietin; parenteral
4.1
6.4
17
42
K05.38
ICD-10 Finland
Other chronic periodontitis
2.3
6.3
43
185
SPB06
NOMESCO Finland
Production of temporary clinic-made tooth- or implant-retained crown or bridge unit
3.6
6.3
20
56
K07.64
ICD-10 Finland
Stiffness in the jaw joint UNS
9.3
6.3
12
13
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.4
6.3
39
161
EG1DM
NOMESCO Finland
Mandibular joint very extensive MRI examination with 3 Tesla magnet
+∞
6.3
6
*
EGA10
NOMESCO Finland
Incision of mandibular joint
+∞
6.3
6
*
F60.5
ICD-10 Finland
Anankastic personality disorder
2.5
6.2
38
156
EB1AD
NOMESCO Finland
Cone beam CT of teeth and jaws (one quarter)
5.0
6.2
18
36
OIKVA, ,
NOMESCO Finland
1.8
6.2
81
447
EBA40
NOMESCO Finland
Extraction of apex of root of tooth
3.2
6.1
23
72
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.8
6.1
85
477
DHB50
NOMESCO Finland
Turbinoplasty
2.0
6.1
59
293
N03AE01
ATC
clonazepam; systemic
1.8
6.1
84
471
K03.30
ICD-10 Finland
Internal granuloma of pulp
4.1
6.1
16
39
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
1.6
6.1
145
942
EB1MA, ,
SPAT
8.6
6.1
12
14
WZC00, ,
SPAT
1.3
6.0
370
2867
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
6.7
6.0
14
21
XX7LW, ,
NOMESCO Finland
10.0
6.0
11
11
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
3.2
6.0
23
73

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1159
9418
1.44
16.98
3.5
2.7
75.96
72.03
nmol/l
5.45
1100
8901
316
2009
1.66
14.42
1.6
1.6
1190.90
1177.14
nmol/l
0.08
244
1574
448
3156
1.51
13.08
1.6
1.6
10973037.11
36399995.05
pmol/l
1.05
401
2783
700
5388
1.42
12.89
2.6
2.5
2.59
2.57
mg/l
0.13
625
4723
1343
11568
1.36
12.17
9.5
7.1
1.99
2.05
e9/l
1.81
1244
10350
1243
10598
1.35
11.94
9.2
7.0
54.50
54.93
%
0.72
1208
10218
267
1709
1.63
11.79
5.6
4.9
0.83
0.90
%
0.14
69
442
1318
11360
1.35
11.68
4.3
3.4
8.69
4.54
estimate
0.29
310
2362
1587
14078
1.37
11.63
8.1
7.1
78.45
79.86
u/l
0.52
1520
13413
1323
11417
1.35
11.59
4.3
3.5
0.01
0.01
estimate
0.22
304
2300
1299
11226
1.34
11.03
9.7
7.2
0.04
0.04
e9/l
0.35
1180
9787
256
1650
1.62
10.98
5.7
5.0
0.07
0.10
%
0.35
57
383
1440
12653
1.34
10.82
3.8
3.4
76.99
69.27
ug/l
0.23
1384
12085
254
1642
1.61
10.75
5.1
4.7
0.80
0.58
%
0.38
55
426
1252
10786
1.33
10.74
9.5
7.1
31.36
30.87
%
1.00
1205
10326
1894
17387
1.40
10.60
5.5
4.4
14.48
14.36
pmol/l
1.45
1787
16240
102
502
2.08
10.59
5.6
6.4
1.54
1.61
%
0.22
97
465
1294
11223
1.33
10.48
9.6
7.1
0.53
0.54
e9/l
0.78
1180
9785
1297
11268
1.32
10.31
4.3
3.4
0.00
0.00
estimate
0.33
309
2379
371
2633
1.48
10.27
2.9
2.8
3.97
4.73
e9/l
2.01
334
2390
1200
10315
1.32
10.27
9.8
7.2
2.81
2.86
%
0.35
1146
9764
331
2309
1.50
9.96
2.9
2.2
363.27
374.29
nmol/l
0.40
314
2160
1326
11595
1.32
9.87
10.3
7.5
0.18
0.19
e9/l
1.08
1218
10277
449
3328
1.43
9.87
1.6
1.4
626.52
511.13
titre
0.54
92
645
1599
14356
1.33
9.86
5.5
4.1
—
3.26
—
0
18
1194
10294
1.31
9.83
9.9
7.3
0.69
0.67
%
0.35
1138
9741
1197
10339
1.31
9.66
9.8
7.2
8.39
8.30
%
0.58
1147
9800
2089
19605
1.47
9.59
6.3
5.2
1.79
1.78
mu/l
0.12
2016
18743
91
448
2.07
9.47
5.6
6.9
0.86
0.90
%
0.51
86
414
535
4116
1.38
9.44
1.4
1.3
18.52
23.48
iu/ml
0.78
166
1134
738
5978
1.34
9.32
4.4
3.5
0.00
0.00
estimate
1.70
287
2276
252
1689
1.55
9.12
6.1
5.2
0.49
0.27
%
0.18
45
365
413
3057
1.42
9.09
3.1
2.5
14.53
14.69
umol/l
0.16
397
2869
580
4568
1.35
8.75
2.9
2.6
—
0.90
—
0
10
1385
12304
1.29
8.60
12.3
9.5
3.67
3.88
e9/l
4.09
1271
10706
492
3789
1.37
8.53
1.4
1.3
6.57
8.68
u/ml
0.46
206
1546
377
2778
1.42
8.48
3.1
2.5
2.54
2.49
g/l
0.88
353
2582
209
1366
1.58
8.44
1.8
1.7
8.17
8.56
u/l
0.19
161
1047
701
5712
1.32
8.32
2.7
2.6
56.56
57.25
u/l
0.13
654
5338
1000
8569
1.28
8.05
3.9
3.1
0.02
0.02
estimate
0.05
263
1984
680
5540
1.32
8.03
5.8
4.5
—
—
—
0
0
1062
9173
1.28
8.01
3.7
3.1
6.36
6.26
ph
2.41
603
5181
195
1270
1.58
8.00
8.0
5.3
67.00
67.69
ng/l
0.06
189
1174
506
3962
1.35
7.83
3.2
3.0
136.39
101.84
ug/g
0.94
412
3167
866
7314
1.29
7.73
6.4
5.3
37.59
37.38
g/l
0.64
821
6927
995
8564
1.27
7.59
10.7
7.4
1.22
1.22
mmol/l
0.13
887
7545
285
2047
1.44
7.34
1.4
1.4
181.06
302.77
u/ml
1.26
269
1909
1144
10082
1.25
6.94
12.4
10.1
0.00
0.00
e9/l
1.26
976
8207
54
251
2.18
6.61
1.4
1.5
0.55
0.50
e9/l
0.68
54
251
2244
21613
1.50
6.52
15.3
12.7
67.24
67.55
umol/l
0.36
2217
21361
564
4592
1.30
6.49
2.7
2.1
201.58
192.51
u/l
0.06
535
4402
332
2505
1.38
6.43
3.3
2.7
22.94
23.84
%
0.62
317
2349
33
125
2.66
6.32
50.8
33.6
133.11
128.10
ug/l
0.13
27
110
772
6556
1.26
6.29
3.5
2.7
0.41
0.04
estimate
0.74
258
1972
836
7170
1.25
6.24
1.5
1.5
1.93
1.64
u/ml
0.28
249
1911
696
5843
1.27
6.24
3.0
3.1
2.35
2.36
mmol/l
0.56
641
5452
151
987
1.56
6.15
2.0
2.2
6.81
7.07
iu/ml
0.04
44
241
180
1223
1.51
6.14
3.1
2.4
0.15
0.28
e6/l
1.04
164
1153
287
2133
1.39
6.09
1.7
1.6
17.54
19.23
iu/l
0.47
237
1723
621
5158
1.27
6.06
3.8
3.2
1.02
1.93
kg/l
1.08
400
3320
144
939
1.57
5.93
2.3
1.9
0.00
0.03
estimate
1.54
58
359
533
4356
1.29
5.90
1.7
1.5
20.89
19.77
nmol/l
1.13
471
3889
178
1227
1.49
5.68
1.1
1.1
—
—
—
0
0
2265
21929
1.48
5.61
12.5
9.9
—
—
—
0
0
225
1627
1.42
5.59
3.3
3.5
4.64
4.66
pmol/l
0.16
204
1476
312
2396
1.35
5.39
1.7
1.5
—
—
—
0
0
25
90
2.80
5.30
2.0
2.0
—
—
—
0
0
206
1482
1.43
5.28
2.8
2.1
10.89
10.59
nmol/l
0.17
187
1360
132
868
1.55
5.27
20.8
11.9
1.16
1.16
mg/l
0.06
126
832
57
296
1.95
5.27
1.8
2.0
4.63
5.28
mmol/24h
0.86
52
269
1214
10967
1.21
5.24
7.0
4.9
6.13
6.22
mmol/l
0.76
1110
10058
120
774
1.58
5.22
5.2
3.4
139.07
122.01
ng/l
0.14
109
678
1488
13718
1.22
5.20
5.0
4.0
431.33
999.68
e6/l
0.53
18
142
1026
9128
1.21
5.14
6.1
5.9
10.50
11.11
umol/l
0.74
966
8613
862
7541
1.22
5.11
2.0
1.8
1.25
1.33
mmol/l
1.91
771
6706
307
2378
1.33
5.00
1.3
1.2
—
—
—
0
0
176
1244
1.45
4.97
3.6
3.9
59.93
70.74
e9/l
4.98
130
837
30
123
2.46
4.96
44.5
47.0
6.46
6.95
ug/l
0.68
25
114
313
2440
1.32
4.88
1.9
1.6
—
—
—
0
0
298
2312
1.33
4.80
1.3
1.3
100.72
150.06
u/ml
1.55
124
861
738
6392
1.22
4.76
6.7
7.4
1.09
1.10
inr
0.27
637
5275
1889
17914
1.24
4.73
4.0
3.7
5.51
5.58
mmol/l
1.74
1781
16902
366
2942
1.29
4.54
4.4
3.2
578.46
597.62
ng/l
0.06
297
2366
139
964
1.47
4.36
1.6
2.7
66.91
67.40
g/l
0.31
132
915
239
1825
1.34
4.30
2.1
1.9
0.00
0.03
estimate
1.55
71
444
260
2011
1.33
4.29
10.8
6.6
7.38
7.37
ph
0.23
184
1251
1795
16992
1.22
4.25
4.9
4.5
36.45
36.90
mmol/mol
1.71
1727
16275
59
334
1.79
4.25
1.8
1.7
—
—
—
0
0
59
334
1.79
4.25
1.8
1.7
—
—
—
0
0
59
334
1.79
4.25
1.8
1.7
—
—
—
0
0
59
334
1.79
4.25
1.8
1.7
—
—
—
0
0
102
668
1.55
4.21
1.4
1.3
8.90
4.46
u/ml
0.36
13
61
104
685
1.54
4.19
2.4
1.7
—
—
—
0
0
488
4100
1.24
4.15
3.3
2.7
5.68
8.16
e6/l
4.21
451
3694
2073
19946
1.27
4.10
14.7
11.8
3.90
3.91
mmol/l
0.54
2016
19428
622
5365
1.21
4.09
2.7
2.7
31.67
52.40
ng/l
0.59
311
2508
135
944
1.46
4.08
1.3
1.3
2.75
0.92
u/ml
—
6
67
230
1763
1.34
4.04
5.9
4.2
1.43
1.63
%
4.08
213
1615
2220
21561
1.34
4.03
12.3
9.8
25.10
25.28
u/l
0.15
2172
21069
798
7061
1.19
3.98
2.0
1.8
98.57
98.00
pmol/l
0.14
437
3882
30
137
2.20
3.96
3.6
2.0
0.12
0.33
mmol/l
0.15
30
122
537
4582
1.22
3.92
2.6
2.1
0.95
0.99
mg/l
0.12
398
3378
33
158
2.10
3.88
1.6
1.6
29.13
53.21
%
3.21
24
105
1067
9697
1.18
3.87
3.0
2.8
—
—
estimate
—
0
0
46
249
1.86
3.85
2.8
3.3
159.33
199.63
e6/l
1.06
36
196
87
563
1.57
3.81
1.6
1.6
364.14
368.15
mu/l
0.04
78
458
251
1966
1.31
3.80
10.9
6.7
1.59
1.42
mmol/l
0.46
214
1661
175
1300
1.37
3.78
3.2
3.4
7.37
7.34
ph
0.72
132
956
646
5630
1.20
3.77
2.8
2.4
—
—
—
0
0
852
7620
1.18
3.70
12.1
7.2
1.22
1.22
mmol/l
0.04
803
7158
646
5640
1.20
3.69
3.7
3.7
7.70
8.30
mmol/l
2.39
581
5061
99
666
1.51
3.66
1.4
1.3
10.51
11.89
u/ml
0.10
16
100
97
651
1.51
3.63
2.5
1.7
96.97
132.84
au/ml
1.66
31
197
106
730
1.47
3.51
1.3
1.2
—
—
—
0
0
2173
21102
1.28
3.47
14.1
11.6
18.80
20.36
mg/l
1.63
1732
16632
303
2467
1.26
3.39
2.1
1.9
—
—
—
0
0
234
1846
1.30
3.38
3.5
3.1
10.11
10.25
g/l
0.24
221
1740
306
2497
1.26
3.36
12.8
7.6
1.14
1.14
mmol/l
0.05
288
2353
280
2266
1.27
3.30
4.7
3.6
5.98
6.54
umol/l
0.30
229
1924
14
48
2.93
3.30
5.6
2.8
—
—
—
0
0
789
7068
1.17
3.28
3.8
3.4
29.18
29.17
u/l
0.00
751
6738
2061
19923
1.23
3.25
14.9
11.7
139.58
139.57
mmol/l
0.11
2012
19472
9
19
4.75
3.23
1.3
1.3
—
—
—
0
0
35
186
1.89
3.15
26.1
24.7
1287.37
1413.92
nmol/l
0.39
35
180
213
1676
1.30
3.15
3.7
3.2
0.22
0.22
g/l
0.89
197
1597
9
20
4.51
3.11
2.1
1.9
—
—
—
0
0
1827
17488
1.18
3.10
3.7
3.4
1.15
1.20
mmol/l
2.39
1753
16669
459
3950
1.20
3.02
1.9
1.7
—
—
—
0
0
158
1203
1.34
2.97
14.8
6.2
—
—
—
0
0
43
249
1.74
2.96
1.8
1.4
—
—
—
0
0
714
6389
1.17
2.96
7.6
6.3
—
—
—
0
0
109
783
1.41
2.93
5.6
5.1
1.20
1.33
%
0.51
109
777
1949
18784
1.19
2.93
4.4
3.9
4.61
4.68
mmol/l
2.86
1879
18050
74
493
1.52
2.93
2.7
2.9
3.70
3.28
index
0.12
47
282
13
46
2.84
2.92
2.4
2.9
0.63
0.63
mmol/l
0.01
13
46
19
82
2.33
2.91
5.1
3.5
—
—
—
0
0
27
135
2.01
2.90
2.3
3.2
8.75
10.02
mg/l
0.95
20
121
10
27
3.71
2.88
1.4
1.2
—
—
—
0
0
25
122
2.06
2.87
4.6
5.2
213.29
165.04
umol/l
0.25
17
70
419
3594
1.20
2.86
3.2
2.8
534.63
544.82
mosm/kgh2o
0.37
378
3157
45
267
1.70
2.86
1.7
1.7
—
—
—
0
0
102
728
1.42
2.85
5.7
5.1
316.73
371.83
mg/l
0.21
55
408
79
537
1.49
2.85
1.5
1.4
17.45
17.55
u/l
0.01
68
462
308
2567
1.23
2.81
4.4
3.1
29.14
29.40
s
0.34
295
2506
178
1390
1.30
2.81
1.3
1.2
—
—
—
0
0
181
1417
1.30
2.80
1.7
2.0
1.14
1.25
g/l
1.22
172
1346
1955
18867
1.18
2.80
4.7
4.2
2.72
2.79
mmol/l
3.84
1876
18051
53
332
1.61
2.75
1.0
1.3
3.41
3.53
u/ml
0.02
23
161
7
14
5.01
2.73
1.0
1.1
—
—
—
0
0
75
510
1.49
2.71
1.4
1.4
299.78
323.63
ug/g
0.43
36
271
47
287
1.65
2.70
2.6
3.2
1108.13
1387.51
e6/l
1.95
38
233
2373
23432
1.53
2.68
22.8
17.8
6.53
6.76
e9/l
4.83
2334
22925
130
978
1.35
2.67
5.0
3.6
20.85
21.04
s
0.15
113
883
2373
23433
1.53
2.67
22.9
17.9
135.13
135.19
g/l
0.09
2360
23259
2372
23422
1.52
2.66
22.6
17.7
29.92
29.85
pg
1.21
2356
23248
2372
23423
1.52
2.64
23.6
18.2
40.31
40.71
%
0.92
2357
23238
2372
23424
1.52
2.63
22.7
17.8
4.54
4.55
e12/l
0.54
2333
22935
2371
23413
1.51
2.62
22.7
17.8
262.83
265.03
e9/l
0.97
2333
22963
1980
19158
1.18
2.60
18.3
14.4
13.20
13.24
%
1.11
1955
18921
10
30
3.34
2.60
1.2
1.2
64.80
32.45
%
—
5
20
1936
18700
1.17
2.59
4.4
3.9
1.49
1.48
mmol/l
0.94
1861
17887
245
2013
1.24
2.57
1.5
1.4
—
—
—
0
0
180
1426
1.28
2.57
15.2
9.7
5.03
5.08
kpa
0.33
174
1371
180
1426
1.28
2.57
15.1
9.7
13.78
13.69
kpa
0.08
174
1372
6
11
5.47
2.54
7.2
2.3
4.75
4.28
mmol/l
—
6
11
2371
23420
1.50
2.53
22.7
17.7
89.47
89.31
fl
0.94
2355
23245
83
585
1.43
2.52
1.3
1.2
28.95
39.44
u/ml
—
8
46
53
340
1.57
2.52
2.0
1.6
24027.44
9020.44
e6/l
0.42
43
250
10
31
3.23
2.51
1.1
1.7
—
—
—
0
0
462
4043
1.18
2.50
3.2
2.6
305.02
311.71
umol/l
0.84
422
3701
11
37
2.98
2.48
1.0
1.2
—
—
—
0
0
112
834
1.36
2.48
2.3
1.6
178.12
217.53
u/ml
0.99
58
472
32
181
1.78
2.43
17.4
18.0
797.03
809.95
nmol/l
0.05
32
175
40
242
1.66
2.41
2.7
3.3
400.30
521.45
e6/l
1.69
30
184
1562
14890
1.14
2.40
3.8
3.2
30.87
33.86
u/l
1.59
1497
14356
178
1422
1.27
2.39
15.3
9.8
7.42
7.41
ph
0.34
105
719
92
669
1.39
2.37
2.0
1.7
45.73
41.65
nmol/l
0.44
92
655
223
1836
1.24
2.32
1.8
1.6
340.65
308.31
mu/l
0.53
208
1658
25
134
1.87
2.26
3.7
3.8
0.80
0.70
index
0.19
25
134
35
209
1.68
2.23
1.1
1.2
—
—
—
0
0
23
121
1.91
2.20
1.3
1.2
69.17
69.17
ug/l
0.00
23
121
451
3979
1.16
2.20
3.6
3.9
—
—
—
0
0
110
834
1.33
2.20
3.1
2.8
10.61
6.05
umol/l
0.88
75
635
174
1403
1.26
2.19
15.4
9.8
0.67
0.60
mmol/l
0.08
137
1139
44
281
1.58
2.17
3.2
2.8
—
—
—
0
0
38
234
1.63
2.17
1.6
1.2
—
—
—
0
0
157
1252
1.27
2.17
16.4
10.4
95.83
96.02
%
0.09
152
1212
44
282
1.57
2.14
1.0
1.1
0.22
2.98
u/ml
1.13
21
109
32
189
1.70
2.13
4.6
4.2
—
—
—
0
0
60
412
1.47
2.13
2.6
2.0
2.42
2.09
ug/l
0.12
53
370
325
2805
1.18
2.09
2.0
2.4
2.40
2.41
mmol/l
0.75
297
2510
726
6644
1.13
2.08
3.1
2.6
0.00
0.05
0.74
13
62
15
69
2.18
2.04
1.9
1.1
—
—
—
0
0
15
69
2.18
2.04
1.9
1.1
—
—
—
0
0
15
69
2.18
2.04
1.9
1.1
—
—
—
0
0
322
2785
1.18
2.02
9.6
5.2
0.83
0.82
mmol/l
0.32
305
2667
92
690
1.35
2.00
2.2
2.2
—
—
—
0
0
31
187
1.67
1.94
3.1
3.4
0.36
0.29
e9/l
0.33
17
118
191
1580
1.23
1.93
14.0
5.8
4.97
5.08
kpa
1.47
180
1531
36
226
1.60
1.93
1.1
1.2
—
—
—
0
0
74
546
1.37
1.81
1.7
2.4
1.19
1.30
g/l
0.43
66
490
18
94
1.92
1.80
2.8
2.3
14.44
16.52
umol/l
0.38
18
94
1269
12064
1.11
1.79
3.2
2.9
—
8418.33
—
0
12
532
4824
1.13
1.75
4.7
3.8
7.39
7.39
ph
1.40
390
3329
47
322
1.47
1.74
1.1
1.3
0.81
13.14
u/ml
1.02
19
132
208
1756
1.20
1.74
4.5
3.5
32.23
32.27
%
0.02
151
1320
20
110
1.82
1.73
1.1
1.2
241.56
170.71
pmol/l
0.35
20
110
101
787
1.30
1.72
1.8
1.9
0.21
0.22
g/l
0.62
95
748
805
7489
1.11
1.69
2.1
1.9
—
—
—
0
0
55
393
1.41
1.65
3.3
3.8
3.19
3.91
e9/l
2.23
55
393
680
6278
1.12
1.64
1.5
1.5
1.99
2.00
g/l
0.08
463
3937
185
1556
1.20
1.62
14.5
5.8
7.42
7.41
ph
1.74
154
1298
19
106
1.80
1.58
1.1
1.2
—
—
—
0
0
100
789
1.28
1.57
1.1
1.1
2.53
6.56
eliau/ml
1.40
17
120
12
57
2.11
1.55
2.7
1.7
—
—
—
0
0
12
57
2.11
1.55
2.1
3.0
7.94
8.14
mmol/l
0.05
12
57
148
1225
1.22
1.54
3.9
3.6
1.23
1.23
mmol/l
0.30
136
1046
30
192
1.57
1.54
1.2
1.1
114.83
115.28
pmol/l
0.02
30
192
102
812
1.27
1.51
1.8
1.9
1.13
1.18
g/l
0.91
95
774
436
3943
1.13
1.50
3.5
3.7
23.98
58.42
mg/l
7.45
258
2607
9
37
2.44
1.48
1.0
1.1
—
—
—
0
0
16
280
0.57
1.46
2.6
2.7
17.70
96.49
ug/min
—
10
183
171
1444
1.20
1.46
1.3
1.3
66.34
39.48
au/ml
—
8
80
7
28
2.50
1.45
1.4
2.8
3.71
4.00
ug/l
—
7
28
441
4001
1.12
1.44
3.9
4.3
4.56
14.20
mg/mmol
1.45
262
2593
106
853
1.25
1.44
1.8
2.0
5.03
6.74
ug/l
0.77
97
761
699
6511
1.10
1.41
2.6
2.3
—
—
—
0
0
92
731
1.27
1.40
2.0
2.2
87.98
3.57
iu/l
0.49
38
333
313
2788
1.14
1.38
3.2
3.1
130.19
569.90
ng/l
5.24
160
1517
15
82
1.83
1.35
1.1
1.1
—
—
—
0
0
536
4936
1.11
1.35
2.5
2.3
—
—
—
0
0
162
1901
0.84
1.34
2.2
2.0
—
—
—
0
0
23
144
1.60
1.32
1.4
1.7
0.79
0.89
%
0.28
14
68
161
1887
0.84
1.32
2.4
2.4
39.23
63.98
u/l
0.46
142
1572
18
106
1.70
1.29
1.2
1.5
147.61
160.09
mmol/24h
0.32
18
106
11
55
2.00
1.27
9.8
3.3
1.23
1.20
mmol/l
0.48
11
50
148
1740
0.84
1.26
1.4
1.5
—
—
—
0
0
50
371
1.36
1.26
1.4
1.1
—
—
—
0
0
13
70
1.86
1.24
1.5
2.4
25.15
27.76
%
0.43
13
70
26
171
1.53
1.23
4.0
4.4
—
—
—
0
0
18
108
1.67
1.22
1.9
2.5
1.22
1.19
mmol/l
0.49
18
108
11
56
1.97
1.22
2.8
2.3
110.00
108.23
ng/l
0.02
11
56
125
1483
0.83
1.19
1.5
1.6
—
—
—
0
0
8
38
2.11
1.18
1.1
1.1
—
—
—
0
0
137
1161
1.19
1.17
1.6
1.7
—
—
—
0
0
287
2573
1.13
1.17
1.3
1.2
—
—
—
0
0
152
1769
0.85
1.17
1.4
1.5
1.33
1.16
ratio
1.03
88
1057
94
770
1.23
1.14
1.6
1.5
0.51
0.45
nmol/l
0.14
73
624
55
422
1.31
1.13
2.3
2.5
136.40
133.81
g/l
0.38
47
362
101
1212
0.83
1.10
1.8
1.7
0.27
0.25
mg/l
0.10
43
522
178
1553
1.16
1.09
2.3
2.3
22.29
19.87
au/ml
0.15
20
200
18
112
1.61
1.08
1.9
2.4
105.89
105.97
mmol/l
0.03
18
112
133
1134
1.18
1.08
1.2
1.2
1.30
2.93
u/ml
2.27
77
673
174
1518
1.16
1.07
18.1
9.9
6.46
6.56
mmol/l
0.10
168
1478
714
6738
1.08
1.06
1.9
1.8
—
—
—
0
0
10
52
1.93
1.06
2.2
3.3
16.09
16.56
%
—
10
52
649
6101
1.09
1.06
4.3
3.3
57.69
66.40
e6/l
0.11
518
4523
18
113
1.60
1.05
1.9
2.4
3.79
3.93
mmol/l
0.61
18
113
295
2670
1.12
1.04
2.3
2.4
4674.97
7075.29
u/l
0.84
110
1046
110
926
1.20
1.04
1.5
1.4
4.04
3.95
ug/l
0.03
105
875
74
598
1.24
1.04
1.5
1.4
—
1115.33
—
0
15
5
22
2.28
1.03
1.6
1.4
—
—
—
0
0
9
47
1.92
1.02
1.3
1.1
—
—
—
0
0
196
1732
1.14
1.02
1.4
1.2
489.17
114.10
titre
0.42
12
50
124
1058
1.18
1.01
18.1
6.7
9.58
9.57
kpa
0.01
119
1030
122
1426
0.85
1.01
1.4
1.5
1.33
1.25
mm
1.00
89
1042
34
247
1.38
1.01
1.1
1.1
—
—
—
0
0
125
1458
0.85
1.01
1.5
1.5
—
—
—
0
0
189
1667
1.15
1.01
2.0
1.5
—
—
—
0
0
0
29
0.00
0.97
0.0
1.2
—
7.39
—
0
22
168
1905
0.87
0.95
1.5
1.5
67.90
60.05
ug/l
1.06
141
1626
21
141
1.49
0.94
2.0
1.7
—
—
—
0
0
28
200
1.40
0.93
1.0
1.1
—
—
—
0
0
90
753
1.20
0.93
1.1
1.1
5.57
8.17
u/ml
0.87
48
388
801
7629
1.07
0.93
5.1
3.8
63.37
63.23
e6/l
0.00
560
4925
10
55
1.82
0.92
1.1
1.1
—
—
—
0
0
10
55
1.82
0.92
1.1
1.1
—
—
—
0
0
10
55
1.82
0.92
1.1
1.1
—
—
—
0
0
6
28
2.15
0.91
1.2
1.0
85.33
85.71
titre
—
6
28
210
1885
1.12
0.88
4.4
4.0
1.71
1.76
ug/l
0.08
197
1724
200
1792
1.13
0.87
19.8
10.5
—
—
—
0
0
34
255
1.34
0.86
3.7
4.4
59.22
118.49
u/ml
—
9
79
39
299
1.31
0.86
1.3
1.4
0.37
0.37
g/l
0.05
30
225
39
299
1.31
0.86
1.3
1.4
3.27
2.76
g/l
0.87
30
227
39
299
1.31
0.86
1.3
1.4
6.79
6.19
g/l
0.63
31
227
168
1491
1.14
0.85
1.4
1.3
236.51
228.32
miu/ml
0.11
82
745
28
204
1.38
0.85
1.3
1.4
0.73
1.29
promille
1.46
20
164
8
45
1.78
0.84
1.0
1.0
5.54
5.31
u/ml
—
8
45
71
588
1.21
0.84
3.1
3.2
51.21
56.55
%
2.83
71
588
11
178
0.62
0.83
2.6
3.3
—
—
—
0
0
16
105
1.53
0.81
2.6
2.2
156.38
158.20
nmol/l
0.02
16
98
13
81
1.61
0.81
1.1
1.1
—
—
—
0
0
10
164
0.61
0.80
1.0
1.1
—
—
—
0
0
6
33
1.82
0.79
1.0
2.2
43.33
43.27
g/l
—
6
33
0
25
0.00
0.79
0.0
3.8
—
—
—
0
0
16
106
1.51
0.79
2.9
2.1
—
—
—
0
0
55
447
1.24
0.78
8.7
6.2
65.91
64.99
%
0.13
55
437
27
199
1.36
0.78
1.0
1.0
—
—
—
0
0
13
82
1.59
0.78
1.0
1.0
—
—
—
0
0
210
1903
1.11
0.77
1.8
2.1
—
—
—
0
0
24
175
1.38
0.74
1.6
1.2
—
—
—
0
0
19
133
1.43
0.73
1.1
1.1
—
—
—
0
0
19
133
1.43
0.73
1.1
1.2
—
3.09
u/ml
—
0
11
44
354
1.25
0.70
3.0
3.2
19.67
23.64
mg/l
0.46
29
226
284
3064
0.92
0.70
4.2
2.9
3.74
3.70
e6/l
0.02
155
1416
80
685
1.17
0.69
1.2
1.3
—
—
—
0
0
25
187
1.34
0.68
1.1
1.2
1.61
21.92
u/ml
0.83
17
135
45
367
1.23
0.65
5.6
4.1
6.20
6.94
pmol/l
0.45
45
367
35
278
1.26
0.63
1.8
2.1
—
—
—
0
0
12
177
0.68
0.63
1.2
1.9
—
—
—
0
0
46
378
1.22
0.63
1.0
1.1
—
—
—
0
0
11
71
1.55
0.62
2.3
2.1
—
—
—
0
0
127
1136
1.12
0.62
3.4
2.6
0.69
0.69
ug/l
0.02
66
587
14
96
1.46
0.61
2.4
2.8
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
57.90
—
0
5
273
2547
1.08
0.58
1.7
1.5
—
—
—
0
0
10
65
1.54
0.55
1.8
2.0
22.20
16.48
nmol/l
—
5
19
30
239
1.26
0.55
1.3
3.2
1.35
1.79
ratio
0.69
20
135
6
38
1.58
0.54
2.8
1.1
—
—
—
0
0
6
38
1.58
0.54
1.0
1.9
—
—
—
0
0
561
5377
1.06
0.54
4.0
3.2
0.29
0.27
e6/l
0.05
438
3833
26
204
1.28
0.54
1.1
1.3
—
—
—
0
0
91
810
1.13
0.51
1.1
1.1
9.92
5.07
u/ml
0.37
53
453
30
242
1.24
0.51
1.2
1.3
2.18
4.80
u/ml
0.97
19
130
549
5273
1.05
0.49
4.0
3.1
8.22
2.41
estimate
—
9
11
62
539
1.15
0.49
1.3
1.2
—
—
—
0
0
186
1725
1.08
0.48
2.1
2.7
—
—
—
0
0
31
253
1.23
0.48
2.0
1.4
0.53
0.52
nmol/l
0.10
31
245
91
1015
0.89
0.48
1.2
1.3
—
—
—
0
0
7
47
1.49
0.47
1.3
1.6
—
—
—
0
0
24
191
1.26
0.46
2.5
6.7
6.04
6.45
mmol/l
0.43
17
162
200
1865
1.08
0.46
3.5
3.4
—
—
—
0
0
7
49
1.43
0.46
3.0
2.1
—
—
—
0
0
32
264
1.21
0.46
1.9
1.3
—
0.44
nmol/l
—
0
8
5
83
0.60
0.45
1.2
1.1
—
—
—
0
0
860
8366
1.04
0.45
2.4
2.2
—
—
—
0
0
44
375
1.18
0.45
4.2
3.8
—
—
—
0
0
302
2862
1.06
0.44
2.0
2.0
—
—
—
0
0
142
1308
1.09
0.44
1.5
1.4
—
—
—
0
0
8
57
1.40
0.42
1.3
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
3.8
—
—
—
0
0
0
16
0.00
0.41
0.0
3.8
—
—
—
0
0
0
17
0.00
0.40
0.0
1.9
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
16.16
—
0
19
14
106
1.32
0.39
1.7
1.2
—
—
—
0
0
234
2213
1.06
0.38
1.7
2.1
—
—
—
0
0
233
2205
1.06
0.37
1.5
1.5
—
—
—
0
0
268
2818
0.94
0.37
1.3
1.3
—
—
—
0
0
63
562
1.12
0.37
1.9
1.9
—
—
—
0
0
8
113
0.71
0.37
1.3
1.1
109.85
181.61
iu/ml
—
8
113
16
125
1.28
0.37
2.6
2.8
45.49
44.89
%
—
10
65
148
1585
0.93
0.36
1.8
1.6
—
—
—
0
0
35
406
0.86
0.35
2.1
1.7
—
1860.00
—
0
12
15
117
1.28
0.35
1.8
1.3
60910.40
100792.01
e6/l
—
10
75
6
43
1.40
0.35
1.2
1.7
4.93
232358.34
nmol/l
—
6
34
64
575
1.12
0.35
1.8
2.3
20.87
20.78
e6/l
0.00
47
422
112
1036
1.08
0.34
2.2
2.7
—
—
—
0
0
6
44
1.36
0.34
3.3
6.8
—
—
—
0
0
181
1707
1.07
0.34
2.1
2.1
6.21
6.21
ph
0.02
103
1068
37
321
1.16
0.33
4.1
4.1
1.91
2.05
mmol/l
0.13
21
182
13
100
1.30
0.33
1.8
2.0
1.26
1.40
nmol/l
—
8
78
26
219
1.19
0.33
2.0
1.3
0.22
0.24
nmol/l
0.12
19
164
57
512
1.12
0.32
8.7
8.3
—
—
—
0
0
12
154
0.78
0.32
1.0
1.2
—
—
—
0
0
94
1017
0.92
0.31
2.8
4.3
5.05
19.18
ug/l
1.20
61
741
896
8783
1.03
0.31
2.6
2.5
—
—
—
0
0
51
456
1.12
0.31
1.5
1.7
0.87
0.74
g/l
0.30
39
368
34
296
1.15
0.30
1.2
1.4
—
—
—
0
0
142
1335
1.07
0.30
1.5
1.6
65.07
60.16
ug/l
0.39
142
1335
64
582
1.10
0.29
1.9
2.3
333.79
7490.67
e6/l
0.55
53
448
7
56
1.25
0.29
3.6
2.7
31.29
30.13
umol/l
—
7
42
248
2375
1.05
0.29
1.7
2.0
—
—
—
0
0
46
412
1.12
0.28
1.3
1.3
2.35
4.04
u/ml
1.77
17
189
247
2368
1.05
0.28
1.7
2.0
—
—
—
0
0
144
1361
1.06
0.27
1.5
1.4
—
—
—
0
0
239
2492
0.95
0.27
1.5
1.5
3.41
3.37
mmol/l
0.23
149
1637
13
161
0.81
0.27
1.2
1.2
6.46
8.50
mm/h
0.65
13
161
585
5992
0.97
0.27
2.2
1.9
—
—
—
0
0
5
71
0.70
0.26
1.4
1.4
—
—
—
0
0
80
862
0.93
0.26
1.5
1.3
—
—
—
0
0
63
578
1.09
0.25
1.2
1.2
—
—
—
0
0
71
656
1.08
0.25
1.2
1.2
—
—
—
0
0
248
2386
1.04
0.25
1.7
2.0
—
—
—
0
0
18
151
1.19
0.25
2.6
4.2
—
103.66
—
0
24
76
705
1.08
0.24
1.0
1.1
1.34
0.59
u/ml
0.25
20
264
97
909
1.07
0.24
1.7
1.7
8.97
7.80
u/ml
0.12
28
261
106
998
1.06
0.23
1.1
1.1
0.56
1.14
u/ml
1.53
47
538
311
3211
0.96
0.23
1.7
1.7
3.43
3.35
ratio
0.58
216
2312
25
218
1.15
0.23
1.3
1.2
0.53
0.65
ratio
0.79
17
123
73
680
1.08
0.22
1.2
1.1
18.77
17.58
au/ml
0.03
14
166
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
0.08
—
0
5
0
12
0.00
0.21
0.0
2.3
—
36.75
—
0
12
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
362.00
—
0
13
19
164
1.16
0.20
1.8
1.6
—
—
—
0
0
46
422
1.09
0.20
1.1
1.1
—
—
—
0
0
55
509
1.08
0.20
2.1
1.8
—
15.13
—
0
8
29
259
1.12
0.20
1.2
1.2
31.41
36.43
mg/l
0.42
24
209
6
49
1.23
0.20
4.5
5.3
6.67
4.90
kpa
—
6
49
6
49
1.23
0.20
1.2
1.1
—
—
—
0
0
109
1035
1.06
0.20
1.1
1.1
5.92
6.54
u/ml
0.13
60
649
22
250
0.88
0.20
2.6
2.0
—
—
—
0
0
40
367
1.09
0.18
1.3
1.2
—
—
—
0
0
12
100
1.20
0.18
1.3
1.4
57.75
89.02
nmol/24h
1.82
12
100
6
80
0.75
0.15
1.0
1.1
—
—
—
0
0
9
78
1.15
0.15
4.1
2.7
46.22
44.28
%
—
9
78
9
78
1.15
0.15
8.2
5.3
12.33
7.95
%
—
9
78
242
2357
1.03
0.15
1.2
1.2
—
—
—
0
0
73
693
1.06
0.15
1.2
1.1
—
—
—
0
0
7
87
0.80
0.14
1.3
1.3
—
—
—
0
0
241
2350
1.03
0.14
1.7
2.0
—
—
—
0
0
73
694
1.05
0.14
1.2
1.1
—
—
—
0
0
10
84
1.19
0.14
1.8
1.5
0.30
0.04
estimate
—
10
84
104
1001
1.04
0.13
1.1
1.1
1.47
2.87
u/ml
2.03
57
601
13
113
1.15
0.13
1.3
1.1
—
—
—
0
0
55
581
0.95
0.13
1.9
2.1
3.39
3.53
mmol/l
0.54
50
551
86
825
1.04
0.12
3.2
2.5
1.02
1.02
ratio
0.16
73
725
21
231
0.91
0.12
2.6
2.2
—
—
—
0
0
47
443
1.06
0.12
1.2
1.1
—
—
—
0
0
31
288
1.08
0.11
1.2
1.5
—
8.30
—
0
8
48
507
0.95
0.11
1.3
1.3
—
—
—
0
0
11
126
0.87
0.11
1.2
1.1
21.78
38.24
iu/ml
0.85
11
126
20
182
1.10
0.11
4.0
2.3
13.57
31.11
mg/l
3.97
14
120
19
173
1.10
0.10
1.2
1.5
—
—
—
0
0
48
456
1.05
0.10
1.2
1.1
16.00
1210.56
iu/ml
—
8
121
35
329
1.06
0.10
1.2
1.2
—
—
—
0
0
5
44
1.14
0.10
1.0
1.0
158.40
163.20
g/l
—
5
44
10
87
1.15
0.09
2.5
2.5
—
—
—
0
0
5
48
1.04
0.09
1.8
1.3
5.80
5.45
mmol/l
—
5
48
320
3244
0.98
0.08
3.7
2.8
0.73
1.13
e6/l
1.32
187
1601
13
144
0.90
0.08
1.6
1.6
0.77
3.54
u/ml
1.82
13
144
5
61
0.82
0.08
2.0
1.0
—
—
—
0
0
5
62
0.81
0.08
1.0
1.2
—
400.50
—
0
14
489
4842
1.01
0.08
6.1
4.6
92.66
94.02
%
0.70
470
4746
46
480
0.96
0.08
1.2
1.1
2.25
2.78
eliau/ml
0.18
26
216
14
127
1.10
0.08
1.1
1.4
—
—
—
0
0
6
73
0.82
0.07
1.3
1.5
—
—
—
0
0
35
333
1.05
0.07
1.1
1.1
2.00
7.45
iu/ml
—
9
82
19
204
0.93
0.07
1.0
1.0
—
—
—
0
0
8
90
0.89
0.06
1.4
1.2
—
—
—
0
0
14
128
1.09
0.06
3.1
3.6
—
—
—
0
0
9
100
0.90
0.06
1.1
1.2
—
—
—
0
0
16
148
1.08
0.06
1.1
1.0
11.16
15.53
u/ml
0.34
11
102
111
1132
0.98
0.06
1.0
1.1
1.61
1.54
g/l
1.67
111
1132
152
1496
1.02
0.05
1.2
1.2
—
—
—
0
0
800
7959
1.01
0.05
1.8
1.8
—
—
—
0
0
31
324
0.96
0.05
1.1
1.1
7.52
17.02
u/ml
—
10
121
341
3441
0.99
0.05
1.6
1.6
1114.61
999.07
mu/l
0.67
297
2967
22
208
1.06
0.05
1.2
1.2
—
—
—
0
0
14
130
1.08
0.04
2.8
3.1
1200.07
648.68
u/ml
0.78
14
130
15
140
1.07
0.04
1.5
1.4
—
—
—
0
0
110
1083
1.02
0.04
1.0
1.1
0.67
0.63
ratio
—
8
100
17
160
1.06
0.04
1.4
1.1
—
—
—
0
0
44
429
1.03
0.03
1.1
1.1
—
—
—
0
0
84
828
1.02
0.02
2.0
1.7
—
—
—
0
0
15
142
1.06
0.02
1.7
2.7
0.93
1.44
g/24h
—
10
96
18
174
1.03
0.00
1.1
1.6
—
—
—
0
0
19
184
1.03
0.00
1.3
1.6
3.68
6.35
ug/l
3.19
19
159
29
296
0.98
0.00
2.4
2.3
—
—
—
0
0
1948
19474
1.00
0.00
18.8
14.5
333.64
333.29
g/l
0.71
1928
19351
12
115
1.04
0.00
1.0
1.3
—
76.92
%
—
0
12
31
315
0.98
0.00
2.6
3.2
—
—
—
0
0
19
189
1.01
0.00
1.1
1.1
—
—
—
0
0
21
209
1.00
0.00
2.5
2.0
2.77
4.24
u/ml
—
9
64
44
445
0.99
0.00
2.2
2.6
0.73
0.79
nmol/l
0.21
35
386
54
539
1.00
0.00
1.9
2.4
—
—
—
0
0
82
819
1.00
0.00
1.2
1.2
—
—
—
0
0
110
1099
1.00
0.00
1.2
1.1
—
—
—
0
0
13
126
1.03
0.00
1.1
1.3
65.92
71.29
umol/l
0.99
13
126
40
404
0.99
0.00
2.0
3.5
48.73
789.64
u/ml
1.20
33
349
10
102
0.98
0.00
2.5
2.3
—
—
—
0
0
12
118
1.02
0.00
1.1
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
162.20
—
0
5
6
63
0.95
-0.00
1.7
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
95
0.95
-0.00
1.4
1.6
134.00
134.96
nmol/l
—
9
95
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
524.00
—
0
5
7
70
1.00
-0.00
1.0
1.1
—
12.86
%
—
0
7
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
2900.00
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
31.14
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
57
0.88
-0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
71.46
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
1.34
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
330.25
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.09
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
187.60
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
9
89
1.01
-0.00
1.1
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
2.13
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
26.53
—
0
6
19
190
1.00
-0.00
1.1
1.1
1875.32
1447.56
miu/ml
0.76
19
190

Mortality – FinRegistry

Association

Association between endpoint K11_OPEN_BITE and mortality.

Females

Parameter HR [95% CI] p-value
K11_OPEN_BITE 1.305 [1.01, 1.68] 0.04
Birth year 0.992 [0.98, 1.0] 0.077

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 16248 females with K11_OPEN_BITE died.

Males

Parameter HR [95% CI] p-value
K11_OPEN_BITE 1.104 [0.83, 1.47] 0.499
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 11181 males with K11_OPEN_BITE died.

Mortality risk

Mortality risk for people of age

years, who have K11_OPEN_BITE.

N-year risk Females Males
1 0.081% 0.199%
5 0.619% 1.139%
10 1.679% 2.966%
15 3.275% 5.819%
20 5.607% 9.616%

Relationships between endpoints

Index endpoint: K11_OPEN_BITE – Open bite

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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