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Placental disorders

DOID EFO Endpoint Browser PheWeb

O15_PLAC_DISORD

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

None

313377

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — O43
  • Hospital discharge: ICD-9 — 6560|6567
  • Cause of death: ICD-10 — O43
  • Cause of death: ICD-9 — 6560|6567

2 out of 7 registries used, show all original rules.

429

4. Check minimum number of events

None

429

5. Include endpoints

None

429

6. Filter based on genotype QC (FinnGen only)

378

Control definitions (FinnGen only)

Control exclude
O15_MATERN_CARE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
O30-O48
Name in latin
Morbositates placentae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2428 2428 -
Only index persons 2399 2399 -
Unadjusted period prevalence (%)
Whole population 0.07 0.07 -
Only index persons 0.09 0.09 -
Median age at first event (years)
Whole population - 31.60 -
Only index persons - 31.60 -

-FinnGen-

Key figures

All Female Male
Number of individuals 378 378 -
Unadjusted period prevalence (%) 0.13 0.13 -
Median age at first event (years) 32.01 32.01 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
394
Matched controls
3940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
25.0
226.2
200
156
O43.8
ICD-10 Finland
Other placental disorders
+∞
146.2
131
*
O82.0
ICD-10 Finland
Delivery by elective caesarean section
46.1
138.5
84
23
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
1423.1
113.4
105
*
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
15.3
108.1
107
94
O60
ICD-10 Finland
Preterm labour and delivery
34.6
105.5
69
24
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
14.4
101.7
104
96
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
9.6
96.5
145
226
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
9.0
90.6
142
231
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
7.5
90.3
219
564
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
1013.2
86.0
81
*
O43.0
ICD-10 Finland
Placental transfusion syndromes
+∞
73.3
68
*
O43.9
ICD-10 Finland
Placental disorder, unspecified
+∞
68.8
64
*
Z39.2
ICD-10 Finland
Routine postpartum follow-up
5.8
67.7
206
623
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
28.1
65.0
45
18
O32.1
ICD-10 Finland
Maternal care for breech presentation
580.9
52.8
51
*
O35.8
ICD-10 Finland
Maternal care for other (suspected) fetal abnormality and damage
+∞
52.3
49
*
O43.2
ICD-10 Finland
Morbidly adherent placenta
+∞
52.3
49
*
SPAT1379
SPAT
Health check-up of pregnant person
4.8
48.1
152
454
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
4.2
43.8
241
1067
O42.9
ICD-10 Finland
Premature rupture of membranes, unspecified
+∞
43.6
41
*
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
4.2
43.2
181
660
WX320
NOMESCO Finland
Spinalanesthesy
4.6
42.3
133
391
W84
ICPC
Pregnancy high risk
7.1
41.7
70
117
SPAT1380
SPAT
Postpartum check-up
4.5
39.7
129
387
O30.0
ICD-10 Finland
Twin pregnancy
415.8
38.7
38
*
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
3.9
37.0
158
573
W78
ICPC
Pregnancy
3.7
36.6
189
778
SPAT1197
SPAT
Extensive health check-up of expecting family
3.9
35.4
152
551
O44.0
ICD-10 Finland
Placenta praevia specified as without haemorrhage
+∞
34.9
33
*
Z32.1
ICD-10 Finland
Pregnancy confirmed
4.0
34.6
130
429
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
367.3
34.5
34
*
W92
ICPC
Compl labour/ delivery livebirth
10.4
32.9
38
40
OAA11, ,
SPAT
4.7
32.5
89
231
6567A
ICD-9 Finland
Other foetal and placental problems affecting management of mother, Other placental conditions[CONDITIO PLACENTAE ALIA, RASKAUDEN AIKANA]
+∞
30.6
29
*
O46.9
ICD-10 Finland
Antepartum haemorrhage, unspecified
+∞
28.5
27
*
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
3.8
28.1
110
368
WX306
NOMESCO Finland
Lumbar epidural anesthesy
4.8
28.0
71
172
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
4.3
27.9
83
228
O43.1
ICD-10 Finland
Malformation of placenta
+∞
27.4
26
*
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
4.1
26.6
85
246
O48
ICD-10 Finland
Prolonged pregnancy
+∞
26.3
25
*
MAA00
NOMESCO Finland
Amniocentesis
30.8
25.8
34
12
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
6.8
25.4
42
68
O30.01
ICD-10 Finland
Twin pregnancy with a shared chorionic sac and a separate amniotic sac
+∞
25.3
24
*
O35.1
ICD-10 Finland
Maternal care for (suspected) chromosomal abnormality in fetus
+∞
25.3
24
*
O44.1
ICD-10 Finland
Placenta praevia with haemorrhage
+∞
25.3
24
*
ZXD05
NOMESCO Finland
Urgent procedure
3.1
25.1
160
716
Z87.5
ICD-10 Finland
Personal history of complications of pregnancy, childbirth and the puerperium
25.6
23.9
33
14
O72.0
ICD-10 Finland
Third-stage haemorrhage
6.8
23.6
39
63
O41.0
ICD-10 Finland
Oligohydramnios
+∞
22.1
21
*
6567B
ICD-9 Finland
Other foetal and placental problems affecting management of mother, Other placental conditions[CONDITIO PLACENTAE ALIA, SYNNYTYKSEN AIKANA]
+∞
22.1
21
*
O47.1
ICD-10 Finland
False labour at or after 37 completed weeks of gestation
121.8
21.8
23
*
O72.2
ICD-10 Finland
Delayed and secondary postpartum haemorrhage
8.8
21.6
28
34
OAA12, ,
SPAT
4.4
21.3
59
152
MA3AE
NOMESCO Finland
Combined first trimester screening
3.7
21.1
77
242
SPAT1196
SPAT
Monitoring of normal pregnancy
3.7
21.1
76
237
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
3.8
20.4
70
211
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
5.7
20.3
40
77
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
3.9
20.1
66
193
TPH07
NOMESCO Finland
Cathetrisation of artery
5.2
19.9
43
90
O36.8
ICD-10 Finland
Maternal care for other specified fetal problems
210.1
19.7
20
*
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
3.4
18.4
77
264
O40
ICD-10 Finland
Polyhydramnios
+∞
17.8
17
*
8811
FHL
Cesarean section
4.8
17.8
42
95
MBA30
NOMESCO Finland
Manual removal of placenta from delivered uterus
6.9
17.7
28
43
O64.1
ICD-10 Finland
Obstructed labour due to breech presentation
66.3
16.9
19
*
O36.4
ICD-10 Finland
Maternal care for intrauterine death
+∞
16.8
16
*
OAA10, ,
SPAT
3.8
16.6
56
166
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
2.8
16.5
108
475
O02.1
ICD-10 Finland
Missed abortion
3.7
16.5
58
177
WX307
NOMESCO Finland
Obstetric epidural analgesia
2.9
16.5
98
410
O36.3
ICD-10 Finland
Maternal care for signs of fetal hypoxia
+∞
15.7
15
*
FM1NE
NOMESCO Finland
Ultrasound examination of fetal heart
39.8
15.5
19
5
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
2.8
15.5
94
396
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
2.5
14.9
122
595
SPAT1357
SPAT
Monitoring of problem during pregnancy
5.6
14.9
29
55
6560B
ICD-9 Finland
Other foetal and placental problems affecting management of mother, Foetal-maternal haemorrhage[TRANSFUSIO FOETO-MATERNALIS, SYNNYTYKSEN AIKANA]
+∞
14.7
14
*
O35.9
ICD-10 Finland
Maternal care for (suspected) fetal abnormality and damage, unspecified
+∞
14.7
14
*
O99.80
ICD-10 Finland
The fear of childbirth
3.7
14.7
51
154
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
4.6
14.4
35
81
O80.8
ICD-10 Finland
Other single spontaneous delivery
4.2
13.8
38
97
O42.0
ICD-10 Finland
Premature rupture of membranes, onset of labour within 24 hours
+∞
13.6
13
*
B01AB04
ATC
dalteparin; parenteral
5.3
13.6
28
56
TMW99
NOMESCO Finland
Other minor surgical procedure in obstetrics
22.1
13.5
19
9
W90
ICPC
Uncompl labour/delivery livebirth
3.3
13.4
56
190
OAA41, ,
SPAT
4.4
13.3
35
86
O80.0
ICD-10 Finland
Spontaneous vertex delivery
2.2
13.1
196
1224
O28.3
ICD-10 Finland
Abnormal ultrasonic finding on antenatal screening of mother
25.3
12.6
17
7
MBB10
NOMESCO Finland
Packing of delivered uterus
+∞
12.6
12
*
MAA54
NOMESCO Finland
Fetoscopy
+∞
12.6
12
*
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
3.6
12.2
43
131
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
2.5
11.9
91
426
O26.82
ICD-10 Finland
Exhaustion and fatigue pregnancy-related
5.2
11.8
25
51
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
5.5
11.7
23
44
SPAT1249
SPAT
Treatment-related counselling outside office
2.1
11.6
182
1142
MA2BG
NOMESCO Finland
Fetal examination with high intensity magnet
+∞
11.5
11
*
O41.1
ICD-10 Finland
Infection of amniotic sac and membranes
+∞
11.5
11
*
MAB20
NOMESCO Finland
Failed external version
+∞
11.5
11
*
OAA70, ,
SPAT
4.2
11.2
30
75
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.4
11.1
97
480
WW500
NOMESCO Finland
Blood transfusion
5.2
11.1
23
46
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
6.0
11.1
20
35
W85
ICPC
Gestational diabetes
3.3
10.8
43
141
FM1QE
NOMESCO Finland
Extensive ultrasound of fetal heart
18.5
10.8
16
9
O20.8
ICD-10 Finland
Other haemorrhage in early pregnancy
18.5
10.8
16
9
Z39.1
ICD-10 Finland
Care and examination of lactating mother
4.4
10.8
28
68
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
3.3
10.7
43
142
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
5.5
10.7
21
40
PC7NT
NOMESCO Finland
Endovascular occlusion of uteral arteries to stop puerperal bleeding
112.9
10.5
11
*
Z37.0
ICD-10 Finland
Single live birth
2.3
10.5
91
449
O31.8
ICD-10 Finland
Other complications specific to multiple gestation
+∞
10.5
10
*
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
+∞
10.5
10
*
O84.0
ICD-10 Finland
Multiple delivery, all spontaneous
+∞
10.5
10
*
O36.9
ICD-10 Finland
Maternal care for fetal problem, unspecified
+∞
10.5
10
*
O34.3
ICD-10 Finland
Maternal care for cervical incompetence
+∞
10.5
10
*
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
11.0
10.4
19
18
O61.0
ICD-10 Finland
Failed medical induction of labour
11.7
10.2
18
16
O72.1
ICD-10 Finland
Other immediate postpartum haemorrhage
4.3
10.1
27
67
TLW12
NOMESCO Finland
Insertion of frozen embryo
4.2
9.7
26
65
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
4.7
9.4
22
49
ZXE00
NOMESCO Finland
One hour or less
2.0
9.4
160
1015
O46.8
ICD-10 Finland
Other antepartum haemorrhage
+∞
9.4
9
*
MAA06
NOMESCO Finland
Amnioreduction
+∞
9.4
9
*
O31.2
ICD-10 Finland
Continuing pregnancy after intrauterine death of one fetus or more
+∞
9.4
9
*
O34.1
ICD-10 Finland
Maternal care for tumour of corpus uteri
+∞
9.4
9
*
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
3.1
9.4
42
148
B01AB05
ATC
enoxaparin; parenteral
2.2
9.3
101
543
MAC40
NOMESCO Finland
Pharmacological induction or advancement of labor
4.8
9.2
21
46
O20.0
ICD-10 Finland
Threatened abortion
5.1
8.9
19
39
G03GA01
ATC
chorionic gonadotrophin; parenteral
3.0
8.9
42
153
SPAT1189
SPAT
Other ultrasound examination during pregnancy
3.5
8.7
30
90
Z31.5
ICD-10 Finland
Genetic counselling
2.8
8.5
44
168
MBA03
NOMESCO Finland
Curettage of uterus after delivery or abortion
4.6
8.5
20
45
O42.1
ICD-10 Finland
Premature rupture of membranes, onset of labour after 24 hours
+∞
8.4
8
*
O35.0
ICD-10 Finland
Maternal care for (suspected) central nervous system malformation in fetus
+∞
8.4
8
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.9
8.3
196
1370
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
9.2
8.1
16
18
O26.88
ICD-10 Finland
Other specified pregnancy-related conditions
7.5
8.1
18
25
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.9
8.0
39
144
Z35
ICD-10 Finland
Supervision of high-risk pregnancy
8.0
8.0
17
22
TLW00
NOMESCO Finland
Insemination
3.9
7.9
23
61
O47.9
ICD-10 Finland
False labour, unspecified
8.3
7.7
16
20
XMA22
NOMESCO Finland
General examination of pregnant woman
2.7
7.6
41
160
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
7.6
131
825
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
3.1
7.5
31
104
O63.0
ICD-10 Finland
Prolonged first stage (of labour)
6.2
7.5
19
32
MBA05
NOMESCO Finland
Curettage of uterus after abortion
7.9
7.5
16
21
O32.2
ICD-10 Finland
Maternal care for transverse and oblique lie
81.6
7.4
8
*
MA4AT
NOMESCO Finland
Chorion biopsy with ultrasound guidance
81.6
7.4
8
*
J01DB01
ATC
cefalexin; oral
2.2
7.4
336
2851
O30.00
ICD-10 Finland
Twin pregnancy with separate amniotic and chorionic sacs
+∞
7.3
7
*
NE1AG
NOMESCO Finland
MRI pelvimetry with high intensity magnet
+∞
7.3
7
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
7.2
150
997
MAG00
NOMESCO Finland
Assisted breech delivery
30.6
7.2
9
*
Z34
ICD-10 Finland
Supervision of normal pregnancy
2.5
7.0
46
199
O73.1
ICD-10 Finland
Retained portions of placenta and membranes, without haemorrhage
14.1
6.9
11
8
R2110
NOMESCO Finland
Giving the first information
2.6
6.8
41
170
6467A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOSIS GRAVIDARUM]
12.5
6.6
11
9
MBA04
NOMESCO Finland
Curettage of uterus after delivery
8.4
6.4
13
16
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
5.7
6.4
17
31
Z30.2
ICD-10 Finland
Sterilization
2.2
6.3
55
269
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
5.5
6.2
17
32

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
153
467
4.72
46.97
1.7
1.4
1694.93
1040.33
mu/l
0.50
124
387
100
293
4.23
31.07
1.7
1.4
67.65
60.34
ug/l
0.51
84
242
184
945
2.78
21.67
2.0
1.7
—
—
—
0
0
80
260
3.61
20.88
1.7
1.4
—
—
—
0
0
87
301
3.43
20.60
1.6
1.3
—
—
—
0
0
75
244
3.56
19.47
1.7
1.4
1.25
1.25
mm
0.02
50
179
194
1067
2.61
19.34
2.1
1.7
—
—
—
0
0
76
253
3.48
19.03
1.7
1.4
—
—
—
0
0
107
473
2.73
16.15
2.3
1.8
—
—
—
0
0
137
714
2.41
14.44
2.3
2.0
—
—
—
0
0
35
88
4.27
12.93
2.9
1.8
6.94
4.99
umol/l
0.54
27
65
166
989
2.17
12.32
2.5
2.0
—
—
—
0
0
228
1550
2.12
11.83
3.8
2.5
—
—
estimate
—
0
0
16
7
23.74
11.66
4.1
2.0
—
—
—
0
0
191
1244
2.04
10.81
2.6
1.6
—
—
—
0
0
202
1391
1.93
9.28
2.3
2.2
—
—
—
0
0
283
2194
2.03
9.03
4.9
3.6
—
564.54
—
0
24
86
467
2.08
7.62
3.2
2.0
13415.36
4987.51
u/l
0.62
44
174
15
27
5.73
5.74
1.3
1.3
—
—
—
0
0
230
1808
1.65
5.55
3.5
3.2
0.00
0.00
estimate
0.50
51
358
232
1838
1.64
5.34
3.6
3.2
0.00
0.01
estimate
0.50
51
349
90
562
1.78
5.10
2.5
2.4
7.79
10.85
e6/l
0.92
81
516
230
1833
1.61
5.04
3.5
3.2
0.00
0.00
estimate
-0.00
50
355
110
737
1.68
4.83
3.3
2.6
0.13
0.32
e6/l
1.46
74
507
123
862
1.62
4.49
3.2
2.7
28.47
80.14
e6/l
0.80
86
636
22
84
2.71
4.31
1.3
1.5
—
—
—
0
0
155
1161
1.55
4.21
3.8
3.2
93.68
43.51
e6/l
0.42
101
710
370
3428
2.30
4.00
12.6
10.4
18.16
18.05
mg/l
0.02
313
2669
123
886
1.56
3.92
2.6
2.1
—
—
—
0
0
16
54
3.05
3.89
1.3
1.3
—
—
—
0
0
37
188
2.07
3.88
8.0
7.1
-1.03
0.41
mmol/l
1.06
31
145
200
1619
1.48
3.59
5.0
4.0
5.91
6.19
mmol/l
1.67
170
1505
18
69
2.69
3.52
1.2
1.5
27.75
36.30
nmol/l
0.72
18
62
145
1104
1.50
3.52
1.4
1.3
1.20
1.67
u/ml
0.42
45
305
36
189
2.00
3.47
8.1
7.1
7.41
7.41
ph
0.02
14
108
47
271
1.83
3.44
1.7
2.0
0.00
0.07
estimate
—
6
72
81
550
1.60
3.28
2.4
3.6
—
—
—
0
0
354
3271
1.81
3.21
9.9
9.9
139.17
139.52
mmol/l
2.50
344
3197
46
270
1.80
3.19
3.0
2.8
—
—
—
0
0
90
631
1.55
3.17
3.6
2.5
76.32
83.72
ug/g
0.21
78
473
183
1485
1.43
3.10
3.2
2.9
6.51
6.20
ph
3.08
96
854
30
155
2.01
3.04
5.9
8.2
—
—
—
0
0
353
3282
1.73
2.81
10.0
10.0
3.87
3.89
mmol/l
0.98
343
3202
10
28
3.64
2.80
1.3
1.2
—
—
—
0
0
25
127
2.03
2.67
1.2
1.1
2.65
4.85
eliau/ml
—
6
28
172
1411
1.39
2.61
3.2
2.9
0.09
0.04
estimate
0.20
47
299
108
818
1.44
2.58
3.3
3.0
1.02
1.02
kg/l
0.00
66
520
12
44
2.78
2.57
1.2
1.0
—
—
—
0
0
46
292
1.65
2.44
2.2
1.8
6.17
6.17
ph
0.01
33
176
53
351
1.59
2.38
1.1
1.2
—
—
—
0
0
121
952
1.39
2.31
3.6
3.2
0.00
0.01
estimate
0.80
49
346
12
47
2.60
2.29
1.7
1.5
8.60
7.84
mmol/l
0.12
12
47
185
1559
1.35
2.29
10.3
8.5
0.00
0.00
e9/l
0.34
151
1268
5
9
5.61
2.22
1.4
1.6
—
—
—
0
0
69
493
1.48
2.21
2.6
2.4
506.02
509.94
mosm/kgh2o
0.05
61
436
255
2267
1.35
2.16
4.1
3.3
51.58
58.97
ug/l
0.88
243
2181
59
410
1.52
2.16
3.1
2.4
6.41
5.06
e6/l
0.20
29
175
63
448
1.48
2.07
1.2
1.2
—
—
—
0
0
121
973
1.35
1.98
6.2
6.6
1.05
1.05
inr
0.05
102
801
7
22
3.22
1.89
1.0
1.0
—
—
—
0
0
52
364
1.49
1.85
1.7
1.6
1126.06
1150.24
nmol/l
0.07
41
284
22
123
1.84
1.84
1.7
1.6
—
—
—
0
0
5
12
4.21
1.83
1.4
1.8
—
—
—
0
0
37
246
1.56
1.67
6.1
6.1
106.00
104.87
mmol/l
0.88
37
246
8
31
2.61
1.66
1.1
1.4
—
—
—
0
0
99
795
1.33
1.61
2.3
1.8
1.14
0.76
mg/l
0.79
81
589
117
963
1.31
1.60
1.5
1.4
1.98
2.07
g/l
0.34
78
649
42
588
0.68
1.57
1.2
1.3
—
—
—
0
0
11
218
0.49
1.56
1.0
1.1
0.92
0.84
g/l
0.42
11
218
11
216
0.50
1.52
1.0
1.1
1.56
1.61
g/l
0.33
11
216
12
58
2.10
1.50
1.0
1.2
—
—
—
0
0
131
1104
1.28
1.48
6.3
5.0
1.19
1.22
mmol/l
3.03
118
1028
376
3642
1.71
1.42
12.0
9.3
—
—
—
0
0
15
82
1.86
1.37
1.2
1.0
1.24
2.61
eliau/ml
—
8
49
11
206
0.52
1.34
1.0
1.1
—
0.60
—
0
18
6
24
2.52
1.31
1.3
1.2
28.33
32.25
pg
—
6
24
116
1355
0.80
1.26
1.8
1.8
1.31
1.29
mmol/l
0.10
98
1217
13
227
0.56
1.26
3.3
2.2
0.24
0.23
g/l
0.44
13
217
82
665
1.29
1.24
2.4
2.0
276.46
294.19
umol/l
1.09
72
623
22
140
1.61
1.23
2.1
2.3
61.27
75.84
e9/l
1.38
16
100
28
189
1.52
1.22
1.1
1.4
3.10
2.89
ug/l
0.18
28
177
109
918
1.26
1.22
2.2
2.7
57.82
62.56
u/l
0.35
104
860
55
424
1.35
1.19
2.7
2.3
2.51
2.51
g/l
0.04
50
396
18
110
1.67
1.17
8.4
8.8
96.01
94.42
%
1.32
18
110
0
35
0.00
1.15
0.0
1.1
—
—
—
0
0
254
2351
1.23
1.14
7.4
6.6
70.57
71.67
u/l
0.23
240
2241
20
127
1.61
1.14
2.6
2.3
4.69
3.69
iu/l
0.21
11
58
26
176
1.51
1.13
4.0
3.1
1.22
1.23
mmol/l
0.65
19
153
126
1088
1.23
1.13
2.4
2.5
0.08
0.02
estimate
0.31
39
301
104
881
1.25
1.11
2.5
2.1
2.35
2.47
mg/l
0.36
90
756
6
121
0.49
1.07
1.5
1.3
—
—
—
0
0
59
468
1.31
1.06
2.7
2.4
14.22
15.43
umol/l
0.66
54
439
7
33
2.14
1.06
3.3
1.9
27.57
9.01
u/ml
—
7
33
13
75
1.76
1.04
1.2
1.3
1.83
3.93
u/ml
—
6
28
287
3022
0.81
1.01
4.7
4.4
36.50
36.68
mmol/mol
0.17
272
2925
87
730
1.25
1.01
1.3
1.3
1.48
13.64
u/ml
3.77
36
297
25
173
1.48
1.00
2.4
3.5
7.39
7.39
ph
—
9
98
82
685
1.25
0.99
1.5
1.6
—
—
—
0
0
86
723
1.24
0.98
4.6
3.3
96.84
99.01
%
0.45
81
701
250
2663
0.83
0.97
3.0
2.9
29.02
31.59
u/l
0.52
242
2589
164
1472
1.20
0.97
2.0
1.9
—
—
—
0
0
6
28
2.16
0.92
1.3
1.4
91.32
91.94
%
—
6
28
143
1275
1.19
0.90
6.0
5.6
1.20
1.22
mmol/l
1.42
120
1118
10
56
1.81
0.88
2.1
2.2
—
—
—
0
0
11
64
1.74
0.87
1.1
1.0
—
—
—
0
0
59
484
1.26
0.84
1.6
1.3
19.26
22.51
iu/l
0.34
54
410
89
765
1.21
0.83
4.3
3.6
7.40
7.40
ph
0.31
60
531
55
449
1.26
0.82
1.3
1.5
—
—
—
0
0
328
3386
0.81
0.77
3.8
3.9
4.74
4.80
mmol/l
0.56
313
3292
175
1606
1.16
0.75
2.6
2.5
70.48
73.13
nmol/l
0.80
168
1533
156
1704
0.86
0.75
2.3
2.3
—
—
—
0
0
331
3411
0.81
0.74
3.9
4.2
2.86
2.85
mmol/l
0.07
316
3313
10
60
1.68
0.72
4.8
3.3
3.22
4.28
e9/l
—
10
60
306
3174
0.84
0.72
3.2
3.3
1.10
1.17
mmol/l
1.13
291
3067
9
142
0.63
0.71
2.7
2.5
4.76
5.10
kpa
—
9
136
9
144
0.62
0.71
1.1
1.8
—
—
—
0
0
5
26
1.93
0.71
1.0
1.2
4.40
7.96
mm/h
—
5
26
5
26
1.93
0.71
1.8
1.0
—
—
—
0
0
65
551
1.22
0.70
1.5
1.6
125490578.00
41532681.22
pmol/l
0.29
51
496
14
93
1.52
0.70
13.2
8.6
—
—
—
0
0
75
645
1.20
0.70
4.8
4.2
10.32
9.00
mg/mmol
0.12
47
400
7
41
1.72
0.70
1.0
1.0
1.42
1.54
g/l
—
7
36
9
59
1.54
0.69
1.7
1.8
4.96
6.60
pmol/l
—
9
59
13
87
1.51
0.64
10.5
4.7
—
—
—
0
0
328
3371
0.84
0.61
3.6
3.8
1.49
1.54
mmol/l
1.65
313
3269
41
495
0.81
0.61
1.6
1.5
3.55
3.33
mmol/l
0.70
27
316
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
52
439
1.21
0.60
1.9
2.9
4.31
5.71
e9/l
0.76
46
406
8
52
1.55
0.60
1.6
2.0
—
—
—
0
0
0
22
0.00
0.59
0.0
2.0
—
—
—
0
0
45
375
1.23
0.59
1.9
1.8
—
—
—
0
0
0
23
0.00
0.58
0.0
3.6
—
—
—
0
0
6
35
1.73
0.58
1.3
1.5
1.40
1.61
mmol/l
—
6
35
8
55
1.46
0.56
5.8
3.3
15.87
58.28
u/ml
—
8
50
23
177
1.32
0.56
3.2
2.0
21.00
4.62
iu/ml
—
6
40
9
63
1.44
0.52
1.0
1.4
—
—
—
0
0
49
418
1.20
0.52
1.2
1.1
—
—
—
0
0
19
144
1.34
0.51
1.2
1.3
—
—
—
0
0
96
867
1.14
0.51
3.3
3.3
7.42
7.97
mmol/l
0.45
84
772
17
222
0.76
0.48
1.0
1.1
—
—
—
0
0
17
128
1.34
0.48
1.0
1.1
1.55
1.53
u/ml
—
10
62
43
368
1.19
0.45
1.6
1.3
—
—
—
0
0
158
1484
1.11
0.43
4.5
5.1
9.56
9.32
umol/l
0.23
149
1409
115
1063
1.12
0.42
6.0
5.7
—
—
—
0
0
13
96
1.37
0.42
2.7
3.0
1.44
1.43
%
0.01
13
96
13
96
1.37
0.42
2.6
2.8
0.71
0.64
%
0.42
13
96
5
33
1.52
0.41
1.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
6.39
—
0
17
0
17
0.00
0.40
0.0
1.1
—
69.99
—
0
12
14
182
0.76
0.40
2.0
1.7
—
—
—
0
0
7
101
0.69
0.40
1.0
1.2
—
—
—
0
0
22
178
1.25
0.39
2.5
3.8
5.62
5.72
kpa
0.23
22
171
5
35
1.43
0.39
1.2
1.1
123.80
116.31
pmol/l
—
5
35
0
19
0.00
0.39
0.0
1.9
—
—
—
0
0
5
36
1.39
0.38
1.0
1.3
0.50
0.56
nmol/l
—
5
36
5
36
1.39
0.38
1.0
1.9
71.20
64.28
%
—
5
36
312
3044
1.12
0.38
5.8
4.8
14.21
14.20
pmol/l
0.01
299
2902
9
68
1.33
0.38
1.0
1.2
—
—
—
0
0
23
277
0.82
0.36
1.3
1.3
—
—
—
0
0
90
828
1.11
0.36
1.9
1.5
—
—
—
0
0
6
42
1.44
0.35
2.5
1.9
—
—
—
0
0
11
82
1.35
0.34
1.3
1.3
—
—
—
0
0
71
647
1.12
0.34
4.1
3.7
57.76
46.53
mg/l
0.22
47
413
32
277
1.17
0.32
1.2
1.3
219.40
248.67
miu/ml
0.13
12
153
53
477
1.13
0.31
1.4
1.2
222.78
143.40
u/ml
0.30
18
203
104
973
1.09
0.31
5.0
4.2
—
—
—
0
0
14
111
1.27
0.30
2.6
2.0
—
—
—
0
0
134
1269
1.08
0.30
2.0
1.9
99.26
99.45
pmol/l
0.01
70
725
46
412
1.13
0.30
2.9
3.3
0.87
0.82
mmol/l
0.75
41
395
10
76
1.32
0.28
4.9
3.1
53.40
58.47
%
—
10
76
47
424
1.12
0.27
3.1
2.6
60.11
444.26
ng/l
0.94
19
193
22
187
1.19
0.27
4.3
3.5
—
—
—
0
0
16
192
0.83
0.26
1.3
1.6
0.17
0.27
mg/l
—
5
72
110
1040
1.08
0.26
2.5
2.9
2.33
2.34
mmol/l
0.67
102
972
39
350
1.13
0.25
3.5
2.2
3.58
4.76
umol/l
2.35
30
295
34
379
0.89
0.23
1.5
1.3
—
—
—
0
0
13
106
1.23
0.23
1.0
1.0
3.45
6.54
u/ml
—
7
44
5
38
1.32
0.23
2.2
1.5
18.24
24.97
ng/l
—
5
38
33
295
1.13
0.23
1.4
1.2
—
—
—
0
0
15
125
1.21
0.22
1.1
1.0
0.60
1.76
u/ml
—
6
50
5
40
1.25
0.22
1.0
1.2
—
—
nmol/l
—
0
0
102
969
1.07
0.21
4.8
5.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
3.1
—
6.36
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
26.00
—
0
12
0
12
0.00
0.21
0.0
3.2
—
0.62
—
0
12
205
1993
1.06
0.21
8.1
8.8
4.07
3.92
e9/l
0.44
184
1752
18
155
1.17
0.20
1.1
1.1
0.39
3.63
u/ml
—
7
76
14
118
1.19
0.19
1.0
1.0
3.99
4.71
u/ml
—
7
58
77
814
0.93
0.19
1.3
1.3
25.77
23.39
iu/ml
0.07
21
258
87
830
1.06
0.16
2.2
2.8
14.86
23.93
ng/l
0.60
27
348
6
76
0.79
0.15
1.0
1.5
—
—
—
0
0
35
379
0.92
0.15
1.2
1.4
—
—
—
0
0
9
82
1.10
0.15
8.8
4.5
36.97
36.93
°c
—
9
82
7
89
0.78
0.14
1.1
1.1
—
13.25
—
0
30
28
256
1.10
0.14
1.3
1.9
—
—
—
0
0
169
1732
0.96
0.14
6.3
5.6
29.96
29.87
%
0.04
158
1651
10
117
0.85
0.13
1.4
1.1
—
—
—
0
0
10
117
0.85
0.13
1.4
1.1
—
—
—
0
0
324
3209
1.05
0.12
16.7
13.3
333.00
331.94
g/l
1.54
324
3188
185
1812
1.04
0.12
6.7
5.9
0.54
0.52
e9/l
0.53
167
1604
191
1874
1.04
0.11
6.7
6.3
0.19
0.17
e9/l
0.70
175
1693
72
749
0.95
0.11
2.5
2.5
—
—
—
0
0
185
1816
1.04
0.11
6.8
5.9
0.04
0.04
e9/l
0.08
166
1605
40
378
1.06
0.10
1.6
1.4
—
—
—
0
0
25
232
1.08
0.10
1.2
1.2
—
—
—
0
0
15
135
1.12
0.10
1.1
1.0
2.45
5.29
u/ml
—
8
74
37
390
0.94
0.09
2.3
1.8
—
—
—
0
0
14
126
1.12
0.09
1.4
1.1
—
—
—
0
0
34
359
0.94
0.09
1.5
1.9
—
—
—
0
0
20
216
0.92
0.08
1.2
1.4
—
—
—
0
0
26
277
0.93
0.08
1.1
1.4
—
—
—
0
0
8
77
1.04
0.07
1.3
1.0
—
—
—
0
0
8
78
1.03
0.07
1.3
1.1
—
—
—
0
0
28
294
0.95
0.06
4.0
4.7
0.83
1.09
%
—
6
70
168
1700
0.98
0.05
6.0
5.5
56.52
56.39
%
0.06
156
1637
14
151
0.92
0.05
1.1
1.4
45.71
138.68
pmol/l
0.72
14
145
64
626
1.03
0.04
1.3
1.4
970.00
560.60
titre
—
8
134
10
91
1.10
0.04
1.5
2.4
19.90
99.79
ng/l
—
10
81
34
332
1.03
0.02
1.1
1.5
—
—
—
0
0
34
332
1.03
0.02
1.1
1.5
—
—
—
0
0
77
762
1.01
0.01
1.7
1.5
21.45
19.96
nmol/l
0.46
69
689
165
1658
0.99
0.01
6.4
5.7
0.68
0.69
%
0.08
151
1560
187
1878
0.99
0.01
6.8
5.9
2.06
1.99
e9/l
0.53
176
1703
316
3154
1.01
0.00
3.5
3.8
5.42
5.56
mmol/l
2.62
305
3028
165
1656
0.99
0.00
6.4
5.6
2.75
2.69
%
0.12
151
1566
165
1656
0.99
0.00
6.4
5.7
8.13
8.14
%
0.02
151
1571
10
102
0.98
0.00
1.7
1.3
—
—
—
0
0
31
312
0.99
0.00
1.1
1.5
—
—
—
0
0
363
3628
1.01
0.00
10.7
9.0
23.19
23.42
u/l
0.11
354
3559
20
201
0.99
0.00
1.2
1.2
—
—
—
0
0
28
281
1.00
0.00
4.0
4.6
0.17
0.94
%
—
6
61
340
3401
1.00
0.00
6.6
5.7
1.57
1.74
mu/l
3.48
327
3303
13
127
1.02
0.00
1.2
1.2
—
—
—
0
0
22
223
0.99
0.00
1.1
1.1
—
—
—
0
0
28
283
0.99
0.00
4.0
4.8
0.17
0.08
%
—
6
59
34
337
1.01
0.00
1.1
1.5
—
—
—
0
0
33
334
0.99
0.00
1.1
1.5
—
—
—
0
0
5
54
0.92
0.00
1.2
1.3
—
—
—
0
0
8
88
0.91
-0.00
1.3
2.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
1.20
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
6.35
—
0
6
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
80.00
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
4.63
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
69.00
—
0
7
6
59
1.02
-0.00
1.2
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
50.30
—
0
5
8
80
1.00
-0.00
2.9
3.6
25.99
25.16
mmol/l
—
8
75
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
58
0.86
-0.00
7.6
6.0
402.00
407.48
umol/l
—
5
48
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.65
—
0
5
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint O15_PLAC_DISORD and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_PLAC_DISORD.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: O15_PLAC_DISORD – Placental disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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