No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
649 |
4. Check minimum number of eventsNone |
649 |
5. Include endpoints |
689 |
6. Filter based on genotype QC (FinnGen only) |
602 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E20-E35
- Name in latin
- Perturbationes pubertatis non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Disorders of puberty
based on the number of shared cases.
Similar with more cases:
- Disorders of puberty, all
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13514 | 6222 | 7284 |
| Only index persons | 12248 | 5115 | 7133 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.18 | 0.20 |
| Only index persons | 0.24 | 0.19 | 0.27 |
| Median age at first event (years) | |||
| Whole population | 12.30 | 9.31 | 14.85 |
| Only index persons | 12.72 | 9.74 | 14.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 602 | 376 | 226 |
| Unadjusted period prevalence (%) | 0.12 | 0.13 | 0.10 |
| Median age at first event (years) | 12.38 | 10.85 | 14.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 639
- Matched controls
- 6390
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
23.2
228.2
181
107
E30.1
ICD-10 Finland
Precocious puberty
846.8
196.2
183
*
E30.00
ICD-10 Finland
Familial delayed puberty
1179.3
186.3
173
*
E30.09
ICD-10 Finland
Delayed puberty NOS
2409.6
185.9
171
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
38.4
155.7
98
30
E30.8
ICD-10 Finland
Other disorders of puberty
+∞
86.5
81
*
L02AE02
ATC
leuprorelin; implant, parenteral
28.3
83.2
57
22
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
439.4
79.7
78
*
E34.35
ICD-10 Finland
Abnormal growth retardation
144.4
62.1
65
5
E22.80
ICD-10 Finland
Central precocious puberty
457.4
43.7
43
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
37.9
36
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
+∞
35.8
34
*
H01AC01
ATC
somatropin; parenteral
366.4
35.3
35
*
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
72.9
25.0
28
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
124.5
22.7
24
*
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
22.0
21
*
2590A
ICD-9 Finland
Other endocrine disorders, Delay in sexual development and puberty, not elsewhere classified
+∞
19.9
19
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
18.8
18
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
21.6
17.4
25
12
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
65.1
16.8
19
*
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
7.2
16.6
25
36
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
29.4
15.3
20
7
H03AA01
ATC
levothyroxine sodium; systemic
2.5
14.9
103
452
N91.0
ICD-10 Finland
Primary amenorrhoea
17.0
14.9
23
14
301
Kela drug reimbursment
Growth hormone
153.4
14.5
15
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.7
14.2
80
317
G03FB08
ATC
dydrogesterone and estrogen; systemic
16.2
14.0
22
14
E34.45
ICD-10 Finland
Abnormal growth increase
142.9
13.5
14
*
Z3231
NOMESCO Finland
Registered nurse
2.0
13.5
206
1241
104
Kela drug reimbursment
Thyroid insufficiency
4.5
13.5
33
76
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.0
13.1
61
218
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.9
13.0
39
105
XW000
NOMESCO Finland
Bone marrow biopsy
5.0
13.0
28
58
G03DB01
ATC
dydrogesterone; oral
3.1
12.5
53
179
E29.1
ICD-10 Finland
Testicular hypofunction
24.9
12.5
17
7
E34.30
ICD-10 Finland
Short stature NOS
132.5
12.5
13
*
602
Kela drug reimbursment
Children's severe malnutrition
4.8
12.2
28
61
H02AB09
ATC
hydrocortisone; systemic
3.8
12.2
38
105
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.6
11.6
73
306
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
10.7
193
1213
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
+∞
10.4
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
10.3
163
981
T99
ICPC
Endocr/metab/nutrit disease other
13.4
10.2
17
13
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
8.3
9.9
21
26
Z3226
NOMESCO Finland
Physiotherapist
2.0
9.5
124
699
F82
ICD-10 Finland
Specific developmental disorder of motor function
4.5
9.4
23
53
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
9.4
9
*
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
+∞
9.4
9
*
E28.3
ICD-10 Finland
Primary ovarian failure
+∞
9.4
9
*
E30.0
ICD-10 Finland
Delayed puberty
+∞
9.4
9
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
9.2
119
668
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.9
9.1
27
72
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
8.8
115
647
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.4
8.7
59
255
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
8.6
105
576
ZY010
NOMESCO Finland
Hospital outpatient
2.2
8.5
74
358
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.3
8.4
63
286
L02AE04
ATC
triptorelin; parenteral
+∞
8.3
8
*
Z2445
NOMESCO Finland
Psychologist
2.2
8.3
75
368
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.0
8.3
36
124
Z2446
NOMESCO Finland
Social worker
2.1
8.2
86
447
ZX120
NOMESCO Finland
Intravenous
2.5
8.0
50
208
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
7.9
80
410
T10
ICPC
Growth delay
11.0
7.8
14
13
XA800
NOMESCO Finland
Neuropsychological investigation
2.6
7.7
44
176
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
6.3
7.6
19
31
A41.9
ICD-10 Finland
Sepsis, unspecified
3.7
7.5
23
63
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.5
7.5
46
190
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.3
7.4
55
249
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
3.6
7.3
24
69
BF10A, ,
NOMESCO Finland
+∞
7.3
7
*
R62.0
ICD-10 Finland
Delayed milestone
3.1
7.1
29
96
ZXE00
NOMESCO Finland
One hour or less
1.6
7.1
216
1539
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.4
7.0
49
215
R1260
NOMESCO Finland
Evaluation of communicative skills
5.9
7.0
18
31
RD210, ,
NOMESCO Finland
2.6
6.9
40
161
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.5
6.8
41
168
L04AA01
ATC
[U] ciclosporin
9.5
6.8
13
14
U04
ICPC
Incontinence urine
3.8
6.7
20
54
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
12.4
6.6
11
9
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.3
6.5
49
223
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
6.5
175
1206
SPAT1139
SPAT
Nutrition survey
3.6
6.5
21
60
ZXA00
NOMESCO Finland
Right side
2.0
6.4
77
419
205
Kela drug reimbursment
Chronic hypertension
2.8
6.4
32
119
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
6.4
146
963
E34.31
ICD-10 Finland
Short stature, prenatal disorder
70.5
6.4
7
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
6.3
32
120
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.5
6.3
39
162
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.9
6.3
90
520
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.0
6.2
68
358
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.1
6.2
61
310
C08CA02
ATC
felodipine; oral
4.2
6.1
16
39
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
3.7
6.1
19
53
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
6.1
110
682
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.3
6.1
22
68
E03.89
ICD-10 Finland
Other specified hypothyroidism
3.4
6.0
21
63
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
171
322
6.89
91.94
3.3
1.7
4.99
5.97
u/l
0.89
127
226
170
330
6.66
88.45
3.2
1.7
8.40
10.30
iu/l
0.54
129
237
64
59
11.94
60.83
2.8
1.9
0.11
0.16
nmol/l
0.89
55
49
132
396
3.94
38.73
3.7
1.8
7.06
12.64
nmol/l
10.34
124
368
32
21
15.97
19.94
2.2
3.1
4.45
3.11
nmol/l
0.85
32
21
213
1193
2.18
17.80
2.9
2.5
2.37
2.37
mmol/l
0.10
201
1115
36
75
5.03
16.56
1.6
1.6
22.96
20.68
ng/l
0.36
36
75
48
139
3.65
14.43
2.1
1.4
0.36
0.36
nmol/l
0.00
40
111
108
501
2.39
13.83
2.8
2.0
373.76
386.08
nmol/l
0.27
102
468
497
4072
1.99
11.77
5.3
3.9
14.50
14.43
pmol/l
0.31
472
3723
276
1937
1.75
10.50
12.6
8.1
1.21
1.22
mmol/l
0.56
243
1733
254
1757
1.74
10.06
12.7
8.7
1.22
1.22
mmol/l
0.02
242
1658
53
213
2.62
9.13
1.8
1.4
7.85
3.50
ug/l
1.32
45
205
290
2138
1.65
8.71
3.7
2.9
68.74
66.63
nmol/l
0.70
274
2027
281
2077
1.63
8.21
1.6
1.7
1.59
2.49
u/ml
0.57
65
479
222
1553
1.66
8.03
7.4
5.8
37.90
38.50
g/l
0.96
211
1460
86
452
2.04
7.95
1.8
1.4
392.78
323.68
mu/l
0.55
81
400
534
4671
1.87
7.94
6.2
4.6
2.07
1.76
mu/l
1.58
516
4434
150
966
1.72
7.31
4.1
2.7
5.40
8.67
e6/l
2.20
135
847
251
1852
1.59
7.12
1.7
1.6
1.89
1.87
g/l
0.09
139
1105
580
5265
2.10
7.02
15.2
9.9
65.84
66.82
umol/l
0.42
571
5178
93
528
1.89
6.86
3.8
2.7
24.20
23.65
%
0.12
87
494
380
3096
1.56
6.86
8.4
6.0
95.30
84.92
u/l
2.39
360
2913
573
5204
1.98
6.54
11.4
8.4
28.93
25.89
u/l
1.26
562
5061
102
610
1.80
6.37
15.7
11.6
25.18
24.79
mmol/l
0.57
102
610
371
3074
1.49
5.71
12.9
9.7
3.72
3.77
e9/l
0.17
321
2614
89
529
1.79
5.66
9.9
5.0
1.41
0.88
mmol/l
0.69
63
382
546
4935
1.73
5.65
19.5
13.2
13.20
13.04
%
2.48
539
4873
529
4747
1.66
5.55
16.2
9.8
3.90
3.88
mmol/l
0.82
511
4588
98
604
1.74
5.50
3.7
2.6
2.53
2.53
g/l
0.00
88
555
625
5938
3.40
5.47
22.4
15.6
265.24
263.42
e9/l
0.28
607
5784
625
5941
3.37
5.41
22.4
15.5
88.03
87.99
fl
0.07
619
5883
250
1929
1.49
5.40
6.6
5.7
10.18
11.30
umol/l
1.23
234
1792
625
5943
3.36
5.36
22.4
15.5
4.61
4.64
e12/l
1.05
605
5779
625
5943
3.36
5.36
23.5
16.1
40.36
41.98
%
1.03
619
5882
105
665
1.69
5.34
11.2
7.7
1.46
1.19
mmol/l
0.45
97
558
528
4751
1.64
5.30
16.3
9.8
139.52
139.53
mmol/l
0.01
512
4607
625
5947
3.33
5.27
22.6
15.7
135.00
136.54
g/l
2.04
619
5890
185
1349
1.52
5.22
4.5
3.2
0.35
0.25
e6/l
0.37
136
945
104
661
1.68
5.22
3.7
2.5
15.17
14.86
umol/l
0.15
96
620
40
186
2.23
5.08
1.9
1.5
38.12
37.24
nmol/l
0.06
40
180
135
924
1.58
5.03
1.7
1.4
18.55
18.25
nmol/l
0.09
118
825
45
226
2.07
4.73
2.8
3.0
1.23
1.23
mmol/l
0.21
40
194
200
1509
1.47
4.71
5.1
3.2
16.92
103.43
e6/l
1.09
149
1093
313
2570
1.43
4.67
7.2
5.5
6.39
6.14
mmol/l
0.67
292
2305
7
5
14.13
4.58
2.3
2.2
1.98
1.94
ratio
—
7
5
18
59
3.11
4.55
3.2
6.0
4.60
6.46
pmol/l
0.92
18
59
79
484
1.72
4.53
3.7
4.7
960.92
940.09
ng/l
0.01
63
372
393
3389
1.41
4.29
5.5
4.0
8.33
7.09
mm/h
1.57
370
3166
21
79
2.71
4.19
2.5
2.9
—
—
—
0
0
15
47
3.24
4.08
4.3
3.2
168.67
69.37
u/ml
—
6
14
27
117
2.37
4.07
1.3
1.3
—
—
—
0
0
27
117
2.37
4.07
1.3
1.3
—
—
—
0
0
205
1594
1.42
4.01
4.2
3.4
31.04
29.15
u/l
0.37
196
1516
46
249
1.91
3.96
3.5
6.8
3.87
3.08
g/l
1.99
46
243
28
126
2.28
3.89
2.0
1.5
120.61
222.59
pmol/l
4.18
28
119
68
420
1.69
3.80
13.2
10.4
106.04
105.45
mmol/l
0.32
68
420
150
1112
1.46
3.77
3.0
3.1
98.16
107.25
ug/g
0.17
122
890
41
219
1.93
3.68
12.6
6.4
130.61
133.27
g/l
0.34
41
211
449
4020
1.39
3.57
11.1
7.4
107.94
106.54
ml/min/173m2
0.71
374
3293
124
896
1.48
3.54
3.0
2.4
184.63
207.03
u/l
0.23
119
862
20
81
2.52
3.49
1.6
2.6
—
—
—
0
0
23
100
2.35
3.47
1.4
1.3
296.74
345.92
ug/g
—
10
44
80
530
1.58
3.40
2.1
2.0
2.42
2.40
mmol/l
1.22
69
457
28
134
2.14
3.38
6.9
7.9
—
440.18
—
0
17
9
18
5.06
3.38
10.1
4.9
16.41
23.61
ug/l
—
9
18
399
3538
1.34
3.16
4.5
3.4
36.66
35.98
mmol/mol
0.64
373
3377
81
550
1.54
3.11
1.4
1.3
136.48
143.88
u/ml
0.07
27
193
13
41
3.21
3.07
1.3
1.1
—
—
—
0
0
187
1490
1.36
3.04
1.9
1.6
94.23
96.34
pmol/l
0.28
99
835
155
1200
1.39
3.01
2.7
2.6
53.90
58.30
u/l
0.50
147
1115
561
5282
1.51
2.93
15.1
10.3
18.70
21.86
mg/l
1.89
446
3952
81
558
1.52
2.91
1.3
1.5
467.85
27869275.35
pmol/l
0.80
71
488
7
13
5.43
2.87
1.4
2.0
—
—
—
0
0
22
103
2.18
2.84
1.5
1.3
1.50
4.75
u/ml
1.22
12
53
9
23
3.95
2.78
8.8
8.8
—
4266.20
—
0
5
79
547
1.51
2.78
5.6
4.5
4.99
6.77
umol/l
0.88
68
442
21
98
2.18
2.73
1.4
1.4
3.08
4.55
u/ml
0.61
12
55
19
85
2.27
2.73
1.3
1.3
—
—
—
0
0
434
3940
1.32
2.67
3.5
2.7
5.48
5.43
mmol/l
0.44
412
3666
42
252
1.71
2.66
2.4
1.7
—
—
—
0
0
170
1361
1.34
2.64
2.7
2.7
2.67
2.40
mg/l
0.86
141
1190
18
81
2.26
2.56
4.2
3.8
5.31
4.80
kpa
2.37
18
81
34
194
1.79
2.56
1.6
1.6
—
—
—
0
0
165
1321
1.34
2.55
4.9
4.2
8.73
9.11
mmol/l
0.37
155
1211
353
3131
1.28
2.52
4.4
3.4
64.58
56.27
ug/l
0.58
331
2971
93
679
1.43
2.51
4.1
3.4
314.64
313.47
umol/l
0.04
88
636
44
274
1.65
2.45
9.2
14.4
-0.21
0.11
mmol/l
0.14
34
233
62
421
1.52
2.41
2.2
1.7
—
—
—
0
0
17
77
2.24
2.39
2.7
1.4
—
—
—
0
0
22
114
1.96
2.23
19.5
8.6
64.64
65.99
%
0.14
22
114
60
414
1.50
2.18
2.3
1.8
—
—
—
0
0
6
14
4.32
2.15
6.0
12.8
—
—
—
0
0
84
623
1.40
2.10
5.9
5.1
7.22
11.45
mg/mmol
0.78
75
479
10
37
2.73
2.07
1.5
1.3
—
—
nmol/l
—
0
0
33
200
1.69
2.06
13.8
6.9
0.59
0.60
%
0.07
33
200
8
26
3.10
2.02
2.3
1.4
22.14
0.92
nmol/l
—
8
19
8
26
3.10
2.02
1.5
1.1
—
—
—
0
0
15
70
2.17
1.99
1.2
2.2
—
—
—
0
0
361
3270
1.24
1.94
6.0
3.9
17.17
1840.61
e6/l
—
6
31
6
16
3.77
1.94
6.0
6.7
—
—
—
0
0
26
150
1.76
1.93
2.3
3.1
455.85
437.13
mg/l
0.06
26
143
36
228
1.61
1.92
7.1
2.7
83.14
91.36
ml/min/173m2
0.47
14
80
77
574
1.39
1.88
2.3
1.9
—
—
—
0
0
32
201
1.62
1.78
1.3
1.3
—
—
—
0
0
139
1141
1.28
1.76
3.9
2.5
—
—
—
0
0
113
903
1.31
1.76
1.6
1.7
1.44
1.38
%
0.64
102
821
6
18
3.35
1.75
4.7
6.8
—
—
—
0
0
8
30
2.69
1.73
3.8
6.4
145.75
160.36
ug/l
—
8
30
105
833
1.31
1.72
3.9
2.9
0.62
1.00
e6/l
1.10
45
404
5
13
3.87
1.72
3.6
1.9
31.80
37.92
umol/l
—
5
13
5
13
3.87
1.72
3.6
2.0
24.60
29.62
umol/l
—
5
13
26
158
1.67
1.65
12.7
17.7
16.02
16.12
%
0.05
26
148
7
26
2.71
1.58
4.1
6.7
—
—
—
0
0
8
33
2.44
1.54
1.6
2.0
—
1224630.00
—
0
5
101
811
1.29
1.52
4.1
3.0
6.38
3.72
e6/l
0.30
42
383
34
226
1.53
1.52
10.3
14.6
121.74
123.31
g/l
0.15
34
218
16
86
1.88
1.51
2.1
2.8
467.36
526.19
e6/l
0.24
11
62
26
163
1.62
1.48
6.2
3.0
192.48
124.36
ng/l
0.31
21
143
16
87
1.86
1.47
2.1
2.9
179.00
186.94
e6/l
0.09
11
64
116
954
1.26
1.45
2.5
3.0
0.97
1.19
mg/l
0.52
84
641
23
141
1.65
1.43
2.9
1.7
—
—
—
0
0
9
41
2.21
1.37
1.1
1.2
149.11
118.22
pmol/l
—
9
41
19
113
1.70
1.33
3.8
11.3
25.03
23.49
mmol/l
0.86
19
104
13
69
1.90
1.29
3.2
1.9
—
—
—
0
0
22
139
1.60
1.24
1.8
3.1
3.80
3.48
mmol/l
0.71
22
133
10
49
2.06
1.22
3.9
1.6
—
—
—
0
0
5
19
2.64
1.22
4.6
1.7
—
—
—
0
0
25
167
1.52
1.14
1.4
1.1
—
—
—
0
0
8
40
2.01
1.12
3.9
4.1
1.63
0.83
index
—
8
40
31
218
1.44
1.11
2.3
1.8
125.70
121.97
au/ml
—
10
73
239
2164
1.17
1.10
3.8
2.9
—
—
estimate
—
0
0
40
297
1.37
1.07
1.4
1.3
—
—
—
0
0
38
280
1.38
1.06
3.7
2.3
—
—
—
0
0
432
4098
1.17
1.06
3.9
3.1
2.70
2.71
mmol/l
0.16
409
3922
290
2672
1.16
1.05
4.7
3.3
0.04
0.00
estimate
0.49
70
532
9
46
1.97
1.04
1.1
1.2
—
—
—
0
0
25
171
1.48
1.04
1.4
1.1
—
—
—
0
0
5
22
2.28
1.03
1.8
3.3
—
—
—
0
0
173
1534
1.18
1.03
3.7
2.5
0.10
0.01
estimate
0.67
62
462
288
2661
1.15
0.99
4.7
3.3
0.00
2.80
estimate
0.50
70
538
14
84
1.68
0.98
2.4
1.2
—
—
—
0
0
59
471
1.28
0.98
3.0
2.3
30.42
135.38
u/l
0.50
50
388
7
36
1.95
0.97
1.0
1.1
83.63
218.81
pmol/l
—
7
36
35
259
1.37
0.97
1.7
1.5
—
—
—
0
0
10
54
1.87
0.97
1.0
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
85
1.66
0.95
8.2
13.5
0.29
0.37
iu/ml
—
9
44
394
3730
1.15
0.93
3.4
2.7
1.20
1.12
mmol/l
1.28
378
3556
20
134
1.51
0.92
3.1
1.7
—
—
—
0
0
13
78
1.68
0.92
2.7
1.5
—
—
—
0
0
14
86
1.64
0.91
3.3
1.8
—
—
—
0
0
17
110
1.56
0.91
2.9
1.4
—
—
—
0
0
115
996
1.19
0.90
1.6
1.6
—
—
—
0
0
153
1359
1.17
0.89
4.8
3.2
0.00
0.00
estimate
0.80
68
528
169
1513
1.16
0.89
2.0
1.8
1.31
1.27
mmol/l
0.24
153
1389
8
42
1.92
0.89
1.3
3.5
—
—
—
0
0
8
42
1.92
0.89
1.3
3.5
—
—
—
0
0
117
1018
1.18
0.88
3.0
2.4
37.54
38.63
ng/l
0.01
53
397
41
317
1.31
0.88
2.0
1.6
174.28
184.08
u/ml
0.15
26
165
6
30
2.01
0.87
1.7
1.3
—
—
—
0
0
46
362
1.29
0.87
1.3
1.6
0.25
0.24
mg/l
0.03
15
153
426
4067
1.14
0.85
3.7
3.0
1.44
1.41
mmol/l
0.63
404
3893
20
137
1.47
0.85
1.8
1.5
0.31
0.48
ug/l
—
7
39
31
231
1.36
0.84
5.8
2.3
0.21
0.55
e6/l
0.42
31
218
6
31
1.94
0.84
1.2
1.5
20.28
17.77
mg/l
—
6
24
6
31
1.94
0.84
1.2
1.5
17.82
21.73
mg/l
—
6
24
284
2646
1.13
0.83
4.8
3.2
0.00
0.00
estimate
-0.00
69
554
32
419
0.75
0.82
1.8
1.6
68.17
57.17
ug/l
0.71
32
419
16
105
1.54
0.82
1.7
1.4
—
1.47
—
0
7
75
633
1.21
0.79
3.3
3.0
174.29
1035.21
ng/l
2.16
34
294
6
33
1.83
0.79
2.5
3.1
570.17
730.94
u/ml
—
6
33
12
74
1.63
0.78
1.8
1.4
52.53
35.30
nmol/l
0.62
12
69
428
4105
1.13
0.74
3.9
3.1
4.49
4.49
mmol/l
0.01
409
3946
16
108
1.49
0.74
1.9
1.4
—
—
—
0
0
10
61
1.65
0.69
2.5
2.4
—
—
—
0
0
62
730
0.83
0.67
1.4
1.5
3.27
3.38
ratio
0.27
41
494
40
322
1.26
0.67
1.6
1.4
—
—
—
0
0
5
28
1.79
0.66
2.2
2.4
107.80
106.21
mmol/l
—
5
28
5
29
1.73
0.64
5.0
1.6
—
—
—
0
0
13
87
1.50
0.63
3.3
1.9
—
—
—
0
0
8
49
1.64
0.62
4.0
3.7
14.38
18.15
index
—
8
40
16
113
1.43
0.61
3.7
3.0
7.30
6.16
index
—
10
71
142
1291
1.13
0.61
3.4
3.0
1.02
1.02
kg/l
0.79
90
790
8
51
1.58
0.60
1.1
1.6
—
—
—
0
0
8
52
1.55
0.59
13.4
29.7
1842.75
1316.79
nmol/l
—
8
52
6
35
1.72
0.58
1.0
1.3
—
—
—
0
0
23
176
1.32
0.57
1.4
1.6
—
—
—
0
0
39
471
0.82
0.56
1.6
1.7
—
—
—
0
0
15
107
1.41
0.55
1.8
1.5
—
—
—
0
0
10
65
1.55
0.55
1.5
2.7
0.76
0.74
e9/l
—
10
65
18
133
1.36
0.55
1.2
1.2
173.00
254.28
iu/ml
—
5
48
54
627
0.85
0.52
1.4
1.5
—
—
—
0
0
15
109
1.39
0.51
1.3
1.1
—
—
—
0
0
213
2264
0.91
0.51
2.9
2.6
—
—
—
0
0
45
381
1.19
0.50
1.6
1.5
1061.35
1083.60
nmol/l
0.07
40
295
40
335
1.21
0.50
1.6
1.4
—
—
—
0
0
17
127
1.35
0.50
1.2
1.1
—
—
—
0
0
10
67
1.50
0.50
1.9
1.3
—
—
—
0
0
7
45
1.56
0.49
1.6
1.2
—
—
—
0
0
356
3425
1.09
0.49
4.1
3.4
33.10
28.17
u/l
1.08
342
3307
24
190
1.27
0.48
4.0
1.7
0.21
0.22
g/l
0.31
24
181
7
46
1.53
0.48
1.6
1.2
—
—
—
0
0
24
191
1.27
0.47
4.0
1.7
1.10
1.18
g/l
0.70
24
181
7
48
1.46
0.47
1.1
1.1
81.57
88.69
%
—
7
48
71
630
1.14
0.46
1.1
1.1
—
—
—
0
0
206
1940
1.09
0.46
4.2
2.9
0.14
0.01
estimate
0.91
63
461
33
275
1.21
0.44
2.7
3.2
3.98
6.74
umol/l
1.51
23
216
5
31
1.62
0.43
1.2
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
24
195
1.24
0.41
13.7
16.3
96.50
94.96
%
2.65
24
195
0
17
0.00
0.40
0.0
1.6
—
—
—
0
0
17
132
1.30
0.40
1.6
1.7
7.38
7.45
mmol/l
0.04
17
127
39
334
1.18
0.40
2.1
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
1.24
—
0
18
513
5221
0.91
0.39
4.4
4.0
—
—
—
0
0
11
80
1.38
0.38
2.7
1.7
4.67
1.54
ug/l
0.31
11
69
9
66
1.37
0.38
2.0
1.3
—
—
—
0
0
9
66
1.37
0.38
2.0
1.3
—
—
—
0
0
9
66
1.37
0.38
2.0
1.3
—
—
—
0
0
51
577
0.87
0.38
1.3
1.4
3.33
3.26
mmol/l
0.20
31
355
9
67
1.35
0.38
2.0
1.3
—
—
—
0
0
18
143
1.27
0.37
1.7
1.3
—
40.73
—
0
6
18
143
1.27
0.37
2.0
2.6
0.89
0.58
nmol/l
0.97
18
119
5
37
1.35
0.37
2.0
1.1
1.04
1.06
ratio
—
5
31
9
70
1.29
0.36
2.2
1.3
—
—
—
0
0
23
189
1.23
0.36
14.2
16.8
0.53
0.67
%
1.06
23
189
203
2133
0.93
0.36
2.6
2.5
—
—
—
0
0
5
78
0.64
0.36
1.0
2.0
—
1467.46
—
0
15
25
208
1.21
0.35
4.6
1.8
10.29
4.82
iu/ml
—
7
35
58
521
1.12
0.33
1.3
1.3
—
—
—
0
0
71
778
0.90
0.33
1.3
1.3
13.41
19.05
iu/ml
0.81
16
176
6
46
1.31
0.33
1.0
1.1
257.00
295.73
mg/l
—
6
41
11
83
1.33
0.32
2.1
1.8
—
—
—
0
0
16
128
1.26
0.32
1.6
1.3
—
36.24
—
0
7
7
53
1.32
0.31
1.0
1.4
—
—
—
0
0
8
63
1.27
0.28
1.3
1.0
—
—
—
0
0
8
64
1.25
0.27
1.3
1.1
—
—
—
0
0
8
65
1.23
0.27
1.3
1.1
—
—
—
0
0
10
128
0.78
0.27
2.4
2.2
—
—
—
0
0
93
991
0.93
0.25
1.6
1.6
1093.22
964.21
mu/l
0.58
85
894
13
106
1.23
0.23
1.8
1.6
—
—
—
0
0
39
431
0.90
0.23
1.9
1.8
—
—
—
0
0
5
40
1.25
0.22
1.2
1.8
—
—
—
0
0
28
315
0.88
0.22
1.4
1.3
—
—
—
0
0
5
41
1.22
0.22
1.2
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.16
0.21
1.4
1.2
—
—
—
0
0
5
43
1.16
0.21
1.4
1.2
—
—
—
0
0
5
43
1.16
0.21
1.2
2.1
123.20
121.26
%
—
5
43
35
316
1.11
0.21
4.0
2.5
30.35
32.98
%
0.77
26
241
47
432
1.09
0.20
1.4
1.4
218.43
247.81
miu/ml
0.21
24
226
19
164
1.16
0.20
1.5
1.6
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
6
50
1.20
0.19
1.2
2.1
98.67
119.50
%
—
6
50
40
366
1.10
0.19
1.1
1.2
7.30
8.33
u/ml
0.15
27
261
51
473
1.09
0.19
1.5
1.5
1.35
1.16
ratio
0.56
34
298
10
81
1.24
0.19
7.2
1.5
13.23
12.84
%
—
10
81
51
474
1.08
0.18
1.5
1.5
0.95
0.95
ratio
0.05
34
299
51
474
1.08
0.18
1.5
1.5
1.27
1.22
ratio
0.11
34
300
23
204
1.13
0.18
1.6
1.7
4.03
8.91
u/ml
—
6
55
7
63
1.11
0.17
1.1
1.6
—
—
—
0
0
68
719
0.94
0.16
1.2
1.2
15.42
6.87
u/ml
0.25
19
264
82
780
1.06
0.16
2.9
2.5
11963.26
6698.25
u/l
0.56
33
295
23
255
0.90
0.15
1.1
1.0
1.45
1.49
g/l
0.38
23
255
10
117
0.85
0.13
2.4
2.1
—
—
—
0
0
27
248
1.09
0.13
1.1
1.1
8.54
9.32
u/ml
0.06
16
142
27
293
0.92
0.12
1.3
1.2
—
5.25
—
0
30
22
200
1.10
0.12
1.1
1.3
—
—
—
0
0
259
2548
1.03
0.11
2.3
2.0
—
—
—
0
0
35
372
0.94
0.10
1.8
2.0
—
—
—
0
0
5
44
1.14
0.10
1.4
1.2
—
—
—
0
0
22
204
1.08
0.08
1.2
1.3
—
—
—
0
0
19
175
1.09
0.08
1.2
2.4
—
—
—
0
0
6
58
1.03
0.08
1.7
1.9
46.00
28.41
mg/l
—
6
37
24
256
0.94
0.08
1.2
1.1
0.90
0.86
g/l
0.40
24
256
7
68
1.03
0.08
1.3
1.5
—
—
—
0
0
9
87
1.03
0.07
1.4
1.3
39.11
44.67
pmol/l
—
9
82
9
105
0.86
0.06
1.7
1.6
0.50
0.50
e9/l
—
9
105
132
1303
1.02
0.04
2.5
2.2
—
—
—
0
0
12
111
1.08
0.04
1.0
1.3
—
—
—
0
0
23
240
0.96
0.03
1.3
1.6
3.62
3.79
mg/l
0.06
16
155
147
1485
0.99
0.03
2.8
2.4
—
—
—
0
0
37
360
1.03
0.03
1.1
1.2
2.36
1.29
u/ml
0.55
26
219
25
241
1.04
0.02
1.1
1.1
0.03
0.36
u/ml
2.22
12
96
26
269
0.97
0.02
1.1
1.1
5.17
7.21
u/ml
0.38
20
164
17
162
1.05
0.02
1.5
2.1
21.76
44.96
u/ml
1.13
17
157
15
155
0.97
0.00
1.1
1.1
—
2.42
—
0
17
19
195
0.97
0.00
1.3
1.1
—
—
—
0
0
29
295
0.98
0.00
4.6
4.0
—
—
—
0
0
40
405
0.99
0.00
1.2
1.2
5.82
3.77
u/ml
0.25
27
256
26
256
1.02
0.00
1.9
2.0
—
—
—
0
0
18
183
0.98
0.00
1.7
2.2
3.10
3.32
iu/l
—
6
88
36
356
1.01
0.00
1.1
1.1
6.62
2.71
u/ml
0.80
23
227
46
462
1.00
0.00
1.5
1.5
—
—
—
0
0
5
51
0.98
0.00
1.6
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.7
—
136.19
—
0
9
5
53
0.94
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
11.30
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
1.21
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
507.86
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
8.57
—
0
7
0
8
0.00
-0.00
0.0
2.5
—
4.65
—
0
8
Mortality – FinRegistry
↥Association
Association between endpoint E4_DISPUB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_DISPUB | 2.342 [1.77, 3.1] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.105 |
During the follow-up period (1.1.1998 — 31.12.2019), 167 out of 5264 females with E4_DISPUB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_DISPUB | 2.384 [1.66, 3.42] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 6399 males with E4_DISPUB died.
Mortality risk
Mortality risk for people of age
years, who have E4_DISPUB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.252% | 0.451% |
| 5 | 1.399% | 2.825% |
| 10 | 3.368% | 6.764% |
| 15 | 6.23% | 12.543% |
| 20 | 10.628% | 20.128% |
Relationships between endpoints
↥Index endpoint: E4_DISPUB – Disorders of puberty
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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