≡ Risteys
R14

Documentation Changelog GitHub Contact & Feedback
info icon

This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Disorders of puberty, all

Endpoint Browser

E4_DISPUB_ALL

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E22.80, E22.88, E30
  • Hospital discharge: ICD-9 — 2590A|2591A|2531X
  • Cause of death: ICD-10 — E22.80, E22.88, E30
  • Cause of death: ICD-9 — 2590A|2591A|2531X

2 out of 7 registries used, show all original rules.

770

4. Check minimum number of events

None

770

5. Include endpoints

770

6. Filter based on genotype QC (FinnGen only)

666

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF9

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 666 430 236
Unadjusted period prevalence (%) 0.14 0.15 0.11
Median age at first event (years) 12.10 10.55 14.93

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
715
Matched controls
7150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E30.1
ICD-10 Finland
Precocious puberty
813.0
194.8
183
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
12.9
186.5
209
222
E30.00
ICD-10 Finland
Familial delayed puberty
1135.3
185.1
173
*
E30.09
ICD-10 Finland
Delayed puberty NOS
2326.5
184.7
171
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
25.7
141.8
102
46
L02AE02
ATC
leuprorelin; implant, parenteral
35.4
140.3
90
29
E22.80
ICD-10 Finland
Central precocious puberty
1172.3
106.1
101
*
E30.8
ICD-10 Finland
Other disorders of puberty
+∞
87.3
82
*
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
291.3
78.1
78
*
E34.35
ICD-10 Finland
Abnormal growth retardation
9.0
57.0
74
91
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
511.2
49.0
48
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
10.7
47.4
53
53
H01AC01
ATC
somatropin; parenteral
6.5
30.9
52
85
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
8.1
27.9
38
49
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
10.4
26.7
30
30
121
Kela drug reimbursment
Severe hypofunction of sexual glands
10.4
24.9
28
28
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
22.0
21
*
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
22.0
21
*
2590A
ICD-9 Finland
Other endocrine disorders, Delay in sexual development and puberty, not elsewhere classified
+∞
19.9
19
*
G03FB08
ATC
dydrogesterone and estrogen; systemic
8.4
19.7
26
32
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
6.7
18.0
29
45
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.7
17.1
100
404
H03AA01
ATC
levothyroxine sodium; systemic
2.5
16.9
124
560
H02AB09
ATC
hydrocortisone; systemic
3.7
16.2
54
156
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.8
15.6
49
136
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
14.3
15.1
25
18
XW000
NOMESCO Finland
Bone marrow biopsy
5.0
14.6
32
67
Z3231
NOMESCO Finland
Registered nurse
1.9
14.3
235
1445
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.6
14.2
89
371
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
5.3
14.2
29
57
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
14.2
200
1167
E27.0
ICD-10 Finland
Other adrenocortical overactivity
11.2
14.1
26
24
E23.00
ICD-10 Finland
Panhypopituitarism
30.7
13.9
18
6
N91.0
ICD-10 Finland
Primary amenorrhoea
11.7
13.9
25
22
L02AE04
ATC
triptorelin; parenteral
+∞
13.6
13
*
G03DB01
ATC
dydrogesterone; oral
2.9
12.8
64
237
R1260
NOMESCO Finland
Evaluation of communicative skills
5.9
12.3
22
38
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
5.6
12.2
23
42
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.5
12.1
84
368
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
11.9
225
1434
F82
ICD-10 Finland
Specific developmental disorder of motor function
4.2
11.7
31
76
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.6
11.7
68
273
104
Kela drug reimbursment
Thyroid insufficiency
3.7
11.2
35
97
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.5
11.1
74
318
T99
ICPC
Endocr/metab/nutrit disease other
10.8
10.8
20
19
Z3226
NOMESCO Finland
Physiotherapist
1.9
10.7
147
841
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.6
10.6
35
101
E29.1
ICD-10 Finland
Testicular hypofunction
12.3
10.4
18
15
602
Kela drug reimbursment
Children's severe malnutrition
3.5
10.3
35
103
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
3.5
9.7
33
97
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
9.7
136
782
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
9.6
135
776
Z2446
NOMESCO Finland
Social worker
2.1
9.5
101
527
E30.0
ICD-10 Finland
Delayed puberty
+∞
9.4
9
*
Z2445
NOMESCO Finland
Psychologist
2.2
9.3
88
438
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
9.3
122
686
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
9.3
99
517
H47.2
ICD-10 Finland
Optic atrophy
15.8
9.1
14
9
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.5
9.0
31
92
F83
ICD-10 Finland
Mixed specific developmental disorders
3.1
8.8
36
119
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
8.8
176
1126
XA800
NOMESCO Finland
Neuropsychological investigation
2.5
8.7
54
224
E34.45
ICD-10 Finland
Abnormal growth increase
9.1
8.6
17
19
ZY010
NOMESCO Finland
Hospital outpatient
2.1
8.5
84
425
ZX120
NOMESCO Finland
Intravenous
2.4
8.5
58
252
NK6NA
NOMESCO Finland
Other bone age measurement with X-ray
91.1
8.4
9
*
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
2.8
8.4
43
162
BF10A, ,
NOMESCO Finland
+∞
8.3
8
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
8.3
60
267
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
8.2
55
237
ZXE00
NOMESCO Finland
One hour or less
1.6
8.1
252
1804
301
Kela drug reimbursment
Growth hormone
6.4
8.1
20
32
C08CA02
ATC
felodipine; oral
4.0
7.9
22
56
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
7.9
205
1401
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
7.9
122
721
ZXA00
NOMESCO Finland
Right side
2.0
7.9
92
496
L04AA01
ATC
[U] ciclosporin
7.1
7.8
18
26
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.9
7.4
107
619
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
7.4
137
854
R62.0
ICD-10 Finland
Delayed milestone
2.8
7.3
35
127
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
4.3
7.0
18
43
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.3
7.0
54
248
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.6
6.9
39
155
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
6.7
66
334
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
6.7
69
356
P85
ICPC
Mental retardation
5.6
6.6
18
33
C09CA01
ATC
losartan; oral
2.3
6.6
47
208
U04
ICPC
Incontinence urine
3.5
6.6
22
64
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
3.3
6.6
24
74
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
12.4
6.6
11
9
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.4
6.4
42
179
T10
ICPC
Growth delay
6.6
6.4
15
23
205
Kela drug reimbursment
Chronic hypertension
2.5
6.3
38
156
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.9
6.3
18
47
H50.31
ICD-10 Finland
Intermittent exotropia
3.1
6.3
26
87
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.9
6.3
28
98
102
Kela drug reimbursment
Diabetes insipidus
26.9
6.2
8
*
RD210, ,
NOMESCO Finland
2.3
6.2
47
214
A50
ICPC
General and Unspecified, Medication/prescr/renewal
3.3
6.2
23
72
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.1
6.2
60
302
127
Kela drug reimbursment
Transplant complication
3.4
6.2
22
67
Z2221
NOMESCO Finland
Medical doctor
1.6
6.2
170
1171
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.1
6.1
25
83
H50.30
ICD-10 Finland
Intermittent esotropy
3.7
6.1
19
53

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
202
493
5.32
80.72
3.5
1.8
5.16
6.84
u/l
1.98
154
341
197
497
5.09
75.27
3.4
1.8
9.02
9.83
iu/l
0.22
151
354
156
521
3.55
38.71
3.7
2.0
7.26
11.08
nmol/l
6.08
144
484
38
50
7.97
27.42
2.1
2.1
3.99
5.47
nmol/l
0.92
38
50
239
1420
2.03
16.46
2.9
2.7
2.37
2.37
mmol/l
0.14
224
1327
133
668
2.22
14.00
3.4
2.3
364.06
376.05
nmol/l
0.32
126
628
58
203
3.02
12.85
2.1
1.6
0.36
0.32
nmol/l
0.18
48
164
568
4705
2.01
12.72
5.5
4.1
14.47
14.41
pmol/l
0.21
541
4314
298
2054
1.77
12.12
12.9
9.1
1.22
1.22
mmol/l
0.31
285
1946
320
2266
1.75
11.74
12.8
8.7
1.21
1.22
mmol/l
0.98
283
2038
609
5341
1.95
9.19
6.3
4.7
2.04
1.77
mu/l
1.57
589
5088
64
283
2.39
8.98
1.8
1.5
7.10
3.98
ug/l
1.10
56
268
333
2507
1.61
8.89
3.9
3.1
68.65
66.68
nmol/l
0.70
316
2378
174
1129
1.72
8.20
4.5
2.9
5.67
8.78
e6/l
2.41
157
998
162
1032
1.74
8.15
4.1
2.8
618.07
579.75
mosm/kgh2o
1.08
148
907
179
1176
1.70
8.04
5.3
3.5
7.39
7.39
ph
0.03
135
803
124
734
1.83
7.98
14.7
12.2
25.17
24.86
mmol/l
0.50
124
734
104
582
1.92
7.97
2.0
1.6
442.30
323.48
mu/l
1.13
99
519
252
1815
1.60
7.84
7.6
6.1
37.83
38.50
g/l
1.29
238
1706
650
5931
2.06
7.26
15.8
10.3
65.55
66.52
umol/l
0.47
641
5839
431
3560
1.53
6.96
8.4
6.2
96.32
87.06
u/l
2.13
410
3361
310
2406
1.51
6.62
1.6
1.7
1.53
2.76
u/ml
0.93
70
553
599
5371
1.71
6.50
16.8
10.4
3.90
3.88
mmol/l
0.89
579
5199
149
986
1.65
6.37
5.4
3.8
—
—
—
0
0
288
2214
1.50
6.37
6.7
5.9
9.99
11.68
umol/l
2.61
270
2065
598
5371
1.69
6.31
17.0
10.4
139.55
139.54
mmol/l
0.04
580
5219
126
801
1.70
6.28
11.1
8.5
7.37
7.37
ph
0.64
89
543
107
650
1.76
6.27
3.8
3.0
23.96
23.21
%
0.19
101
611
247
1848
1.51
6.18
9.6
6.9
—
—
—
0
0
423
3528
1.49
6.17
13.8
9.9
3.84
3.76
e9/l
0.34
367
3003
215
1562
1.54
6.17
4.9
3.4
0.38
0.24
e6/l
0.57
159
1110
279
2146
1.49
6.09
1.7
1.7
1.87
1.85
g/l
0.06
152
1266
115
719
1.71
6.08
11.3
11.2
—
—
—
0
0
641
5886
1.86
6.06
12.0
8.7
29.22
25.66
u/l
1.84
630
5734
74
405
1.92
6.05
7.8
5.1
0.13
0.07
%
0.33
23
84
74
408
1.91
5.92
7.5
4.9
0.92
0.84
%
0.10
26
98
123
789
1.68
5.91
11.1
8.4
1.45
1.18
mmol/l
0.53
113
666
90
530
1.80
5.85
10.1
6.5
—
—
—
0
0
361
2942
1.46
5.77
7.4
5.7
6.36
6.11
mmol/l
0.78
336
2642
19
55
3.52
5.76
4.0
6.0
—
—
—
0
0
369
3025
1.45
5.69
12.2
8.3
0.62
0.66
%
0.76
355
2878
700
6673
3.34
5.66
23.2
16.2
265.37
264.51
e9/l
0.13
681
6508
370
3038
1.45
5.64
12.1
8.2
2.94
2.91
%
0.07
355
2881
700
6676
3.31
5.59
23.1
16.1
87.98
87.96
fl
0.04
694
6616
700
6678
3.30
5.55
23.2
16.1
4.60
4.63
e12/l
1.02
679
6503
700
6678
3.30
5.55
23.1
16.1
29.46
29.53
pg
0.47
694
6618
700
6678
3.30
5.55
24.4
16.7
40.29
41.76
%
1.05
694
6615
10
10
10.12
5.54
3.5
2.1
9.60
4.20
%
—
10
10
700
6682
3.27
5.46
23.3
16.2
6.78
6.75
e9/l
0.14
680
6504
700
6682
3.27
5.46
23.4
16.3
134.80
136.23
g/l
2.02
694
6623
138
929
1.60
5.46
1.2
1.3
—
—
—
0
0
388
3235
1.44
5.32
11.7
8.2
0.56
0.53
e9/l
1.88
336
2759
230
1739
1.48
5.32
5.3
3.5
25.41
91.61
e6/l
0.91
172
1275
384
3197
1.43
5.30
11.7
8.0
32.54
32.31
%
0.16
370
3070
10
11
9.20
5.30
3.6
2.0
27.90
27.55
%
—
10
11
364
3004
1.43
5.26
15.0
10.2
0.02
0.00
e9/l
0.53
288
2379
27
103
2.68
5.20
2.8
4.0
1207.57
1417.53
e6/l
0.63
21
77
101
636
1.68
5.19
10.1
6.4
7.41
7.41
ph
0.07
93
525
386
3234
1.42
5.04
11.7
8.2
0.04
0.04
e9/l
0.06
335
2763
367
3048
1.42
5.04
12.3
8.3
8.42
8.33
%
0.32
351
2895
399
3364
1.42
5.02
11.5
8.0
2.14
2.08
e9/l
0.64
359
2948
194
1433
1.49
5.00
6.4
6.3
1.11
1.09
inr
0.31
168
1211
607
5559
1.61
4.93
20.3
13.9
13.21
13.05
%
2.92
599
5491
277
2196
1.43
4.90
11.5
8.6
—
—
—
0
0
69
396
1.82
4.89
8.0
4.9
0.10
0.07
%
0.13
21
85
373
3123
1.41
4.80
11.6
7.9
52.59
53.35
%
0.61
363
3022
111
734
1.61
4.70
3.7
2.8
2.55
2.55
g/l
0.03
101
679
11
18
6.19
4.61
1.2
1.3
76.45
81.83
nmol/24h
0.10
11
18
118
796
1.58
4.60
3.6
2.8
14.86
14.69
umol/l
0.08
110
750
50
267
1.94
4.43
3.9
3.3
1.23
1.23
mmol/l
0.29
45
230
79
487
1.70
4.39
14.1
10.2
105.73
105.42
mmol/l
0.17
79
487
391
3330
1.38
4.39
13.0
8.5
0.20
0.19
e9/l
0.23
349
2888
233
1824
1.41
4.31
4.2
3.6
36.66
28.88
u/l
0.76
222
1735
67
399
1.75
4.22
6.8
4.6
0.50
0.57
%
0.12
20
98
271
2186
1.39
4.18
6.6
4.1
53.81
62.89
e6/l
0.21
181
1370
47
252
1.93
4.13
2.1
1.6
38.02
38.10
nmol/l
0.01
47
246
21
80
2.67
4.09
1.0
1.0
—
—
—
0
0
55
312
1.83
4.07
10.1
13.5
0.10
0.24
mmol/l
0.07
44
263
85
546
1.63
4.05
1.6
1.9
—
—
—
0
0
87
564
1.62
4.00
4.8
3.4
10.31
10.11
g/l
0.21
80
532
27
118
2.34
3.99
1.4
1.3
289.03
352.81
ug/g
0.79
12
56
12
27
4.50
3.95
1.8
1.4
—
—
—
0
0
146
1068
1.46
3.87
1.6
1.5
18.47
18.37
nmol/l
0.03
128
957
10
19
5.32
3.84
3.6
2.4
167.50
124.63
e6/l
—
10
19
54
315
1.77
3.67
10.3
13.5
7.43
7.42
ph
0.41
28
131
19
73
2.65
3.66
6.4
6.8
4.59
6.56
pmol/l
1.17
19
73
20
80
2.54
3.57
24.1
13.1
11.33
11.86
%
0.30
20
80
24
105
2.33
3.56
6.8
4.9
—
—
—
0
0
496
4468
1.36
3.49
3.6
2.8
5.49
5.44
mmol/l
0.42
473
4160
632
5942
1.55
3.47
15.4
10.7
19.36
21.52
mg/l
1.04
509
4459
91
622
1.53
3.35
2.2
2.1
2.42
2.40
mmol/l
0.78
78
536
21
89
2.40
3.34
1.4
1.2
—
—
—
0
0
100
698
1.50
3.33
2.1
1.6
—
—
—
0
0
25
115
2.22
3.32
1.5
1.3
3.00
4.35
u/ml
0.65
15
60
139
1036
1.42
3.31
2.9
2.4
172.79
261.56
u/l
0.68
134
998
167
1289
1.39
3.25
3.6
2.5
—
—
—
0
0
32
164
2.00
3.24
2.3
1.7
128.19
204.15
pmol/l
3.11
32
154
12
34
3.57
3.21
1.6
2.6
—
—
—
0
0
20
85
2.39
3.17
1.2
1.7
—
—
—
0
0
166
1285
1.38
3.17
3.1
3.0
98.36
99.47
ug/g
0.02
135
1033
21
92
2.32
3.13
5.8
4.0
5.26
4.83
kpa
2.24
21
92
21
92
2.32
3.13
5.8
4.0
1.56
1.98
mmol/l
0.46
15
46
21
92
2.32
3.13
5.8
3.6
9.82
9.49
kpa
0.33
21
92
174
1368
1.36
3.00
2.6
2.6
53.19
58.32
u/l
0.72
163
1273
9
21
4.33
3.00
10.1
3.9
16.41
22.03
ug/l
—
9
21
52
319
1.68
3.00
3.6
5.8
20.38
21.35
s
1.30
47
300
88
613
1.50
2.97
2.1
2.0
—
—
—
0
0
90
630
1.49
2.97
5.8
5.1
4.90
6.74
umol/l
1.13
78
514
43
253
1.74
2.88
13.3
7.6
130.30
131.45
g/l
0.13
43
244
204
1653
1.33
2.87
3.8
2.5
—
—
—
0
0
452
4081
1.29
2.75
4.7
3.6
36.73
35.91
mmol/mol
0.95
425
3900
15
60
2.53
2.71
1.7
1.9
5.47
6.20
mmol/l
—
10
51
15
60
2.53
2.71
4.3
3.0
168.67
83.61
u/ml
—
6
20
43
258
1.71
2.71
11.7
13.7
124.19
123.10
g/l
0.11
43
249
12
40
3.03
2.70
5.0
16.2
12.75
11.26
mmol/l
0.62
12
31
187
1509
1.32
2.69
2.8
2.3
—
—
—
0
0
12
43
2.82
2.65
1.7
1.1
—
—
—
0
0
89
637
1.45
2.64
1.3
1.6
480.54
24460852.29
pmol/l
0.80
79
556
208
1708
1.31
2.63
1.8
1.6
94.90
96.47
pmol/l
0.21
107
961
12
41
2.96
2.63
5.0
15.8
103.42
105.19
mmol/l
0.32
12
32
24
121
2.02
2.58
5.1
3.6
3.32
3.58
e9/l
0.25
24
121
9
25
3.63
2.58
1.2
1.2
—
—
—
0
0
11
36
3.09
2.57
2.4
1.7
—
—
—
0
0
32
179
1.82
2.55
14.7
16.2
16.28
16.20
%
0.05
32
168
24
122
2.00
2.53
5.6
3.9
7.40
7.40
ph
0.11
24
122
57
379
1.55
2.42
5.4
4.6
66.19
63.00
e9/l
0.25
39
244
19
91
2.12
2.34
2.1
4.3
0.25
0.29
e9/l
0.21
12
57
88
644
1.42
2.33
1.4
1.3
131.62
145.69
u/ml
0.14
28
229
185
1518
1.30
2.33
5.1
4.2
8.86
8.98
mmol/l
0.10
173
1402
400
3602
1.25
2.29
4.3
3.5
67.01
55.20
ug/l
0.90
375
3427
17
79
2.18
2.26
2.4
2.4
—
—
—
0
0
160
1293
1.31
2.25
1.9
1.6
—
—
—
0
0
24
128
1.91
2.24
20.5
9.6
66.07
65.25
%
0.08
24
128
20
100
2.03
2.22
2.0
4.1
437.00
533.88
e6/l
0.53
13
73
16
73
2.22
2.22
4.4
1.7
292.75
295.55
mosm/kgh2o
0.26
16
58
105
799
1.37
2.22
4.1
3.4
311.90
314.08
umol/l
0.09
100
753
5
9
5.58
2.21
2.2
2.1
0.57
0.63
mmol/l
—
5
9
60
414
1.49
2.16
1.6
1.5
—
—
—
0
0
410
3716
1.24
2.16
6.1
4.0
15.43
1585.58
e6/l
—
7
38
138
1099
1.32
2.16
2.4
3.0
2.04
1.31
mg/l
0.34
99
740
20
102
1.99
2.12
2.1
4.1
159.15
174.93
e6/l
0.22
13
76
33
200
1.68
2.05
4.2
2.8
54.57
54.77
%
0.03
33
200
83
616
1.39
2.05
4.5
2.5
4.00
4.55
e9/l
0.86
76
556
72
522
1.42
2.03
1.4
1.3
—
—
—
0
0
14
64
2.21
1.95
6.6
2.1
96.86
79.08
mmol/l
0.76
14
53
636
6106
1.38
1.95
12.0
8.3
—
—
—
0
0
9
33
2.75
1.93
2.2
1.4
34.67
32.30
pg
—
9
33
15
71
2.14
1.93
3.5
1.6
97.41
63.22
mu/l
0.38
15
64
26
150
1.76
1.93
1.1
1.2
—
—
—
0
0
23
128
1.82
1.92
3.9
11.1
24.97
23.51
mmol/l
0.98
23
118
95
731
1.35
1.89
5.9
4.9
6.61
10.80
mg/mmol
0.91
84
552
104
812
1.33
1.87
1.7
1.5
—
—
—
0
0
35
222
1.61
1.85
14.6
7.4
0.58
0.61
%
0.19
35
222
278
2452
1.22
1.80
3.7
3.0
—
—
estimate
—
0
0
94
729
1.33
1.78
5.5
4.2
49.86
75.63
mg/l
0.93
85
561
21
117
1.82
1.76
3.6
8.5
—
—
—
0
0
189
1605
1.24
1.76
3.0
2.8
2.59
2.39
mg/l
0.63
159
1407
53
376
1.44
1.71
1.5
1.2
—
—
—
0
0
29
181
1.63
1.66
2.3
3.1
463.48
421.18
mg/l
0.17
29
173
10
41
2.46
1.65
7.7
2.1
22.13
35.13
mmol/l
—
10
41
494
4633
1.21
1.62
4.1
3.2
2.70
2.71
mmol/l
0.13
471
4428
39
263
1.51
1.62
8.0
6.6
247.21
347.79
mg/l
0.84
28
183
5
14
3.59
1.62
1.2
1.1
—
—
—
0
0
85
660
1.33
1.61
2.9
2.1
—
—
—
0
0
8
32
2.52
1.60
3.8
5.9
145.75
157.18
ug/l
—
8
32
115
937
1.27
1.53
4.2
3.1
7.28
3.65
e6/l
0.52
49
449
11
51
2.17
1.51
2.5
1.8
—
—
—
0
0
12
58
2.09
1.50
4.7
3.4
0.67
1.58
%
0.94
12
53
452
4223
1.19
1.47
3.5
2.8
1.21
1.13
mmol/l
1.77
435
4017
5
16
3.14
1.44
3.6
2.4
31.80
36.87
umol/l
—
5
16
5
16
3.14
1.44
3.6
2.4
24.60
28.44
umol/l
—
5
16
5
16
3.14
1.44
1.6
1.1
2506.00
2551.56
ml
—
5
16
6
22
2.74
1.43
1.0
1.4
—
—
—
0
0
488
4595
1.20
1.43
3.9
3.1
1.43
1.41
mmol/l
0.46
466
4392
16
88
1.84
1.42
1.3
1.3
—
—
—
0
0
6
23
2.62
1.37
2.0
1.3
0.00
0.00
estimate
—
6
23
37
258
1.46
1.34
2.2
1.8
—
—
—
0
0
26
168
1.57
1.33
2.2
3.2
2.55
10.34
e6/l
1.00
20
120
199
1744
1.20
1.33
2.1
1.8
1.34
1.28
mmol/l
0.52
182
1600
32
217
1.50
1.33
14.8
15.4
94.83
94.95
%
0.03
32
217
490
4632
1.18
1.31
4.0
3.2
4.49
4.49
mmol/l
0.03
471
4446
281
2541
1.17
1.30
4.3
3.0
6.29
6.31
ph
0.13
145
1301
8
34
2.37
1.29
2.3
1.6
22.14
1.08
nmol/l
—
8
26
26
170
1.55
1.27
2.2
3.2
1803.52
138.19
e6/l
0.67
21
129
9
45
2.01
1.23
2.4
2.3
—
—
—
0
0
31
213
1.48
1.22
15.3
15.6
0.55
0.67
%
1.24
31
213
24
156
1.56
1.21
2.2
3.4
—
—
—
0
0
8
39
2.06
1.15
1.5
1.9
—
—
—
0
0
330
3044
1.16
1.15
4.8
3.3
0.00
2.48
estimate
0.50
74
609
331
3057
1.15
1.13
4.8
3.4
0.04
0.00
estimate
0.49
74
603
11
58
1.91
1.12
1.2
1.1
—
—
—
0
0
133
1141
1.20
1.12
3.0
2.4
33.51
36.03
ng/l
0.03
62
440
86
708
1.24
1.08
1.7
1.6
—
—
—
0
0
10
52
1.94
1.06
1.1
1.3
140.90
119.23
pmol/l
—
10
52
9
46
1.97
1.04
1.1
1.4
—
—
nmol/l
—
0
0
28
196
1.45
1.03
5.9
3.2
186.35
128.46
ng/l
0.28
23
177
7
34
2.07
1.03
1.1
1.2
—
—
—
0
0
18
115
1.58
1.00
2.6
1.9
—
—
—
0
0
34
249
1.38
0.99
2.3
1.9
116.73
121.36
au/ml
0.07
11
88
30
216
1.41
0.97
2.7
1.7
0.00
0.00
estimate
-0.00
16
82
111
952
1.20
0.95
3.0
2.4
—
—
—
0
0
61
492
1.26
0.93
1.3
1.2
—
—
—
0
0
60
738
0.80
0.93
1.3
1.2
—
—
—
0
0
9
52
1.74
0.92
1.0
1.1
—
—
—
0
0
67
548
1.25
0.91
2.9
2.4
30.38
121.63
u/l
0.50
56
448
325
3030
1.13
0.91
4.9
3.3
0.00
0.00
estimate
-0.00
73
627
174
1556
1.16
0.91
5.0
3.2
0.00
0.00
estimate
0.80
71
600
38
289
1.33
0.90
1.2
1.2
—
—
—
0
0
85
716
1.21
0.89
3.1
3.0
225.28
907.25
ng/l
1.84
40
337
8
42
1.91
0.88
1.0
1.1
111.17
206.80
pmol/l
—
8
42
24
169
1.43
0.88
1.7
3.1
3.83
3.45
mmol/l
0.96
24
161
45
354
1.29
0.85
1.9
1.7
191.90
194.19
u/ml
0.03
27
185
50
399
1.27
0.85
1.3
1.6
0.22
0.23
mg/l
0.02
17
167
35
266
1.33
0.84
1.7
1.6
—
—
—
0
0
8
137
0.58
0.84
2.4
2.6
—
22.74
—
0
5
29
214
1.37
0.83
2.3
1.6
—
—
—
0
0
10
59
1.70
0.76
1.3
1.1
—
—
—
0
0
9
53
1.71
0.75
5.1
3.8
1.44
0.79
index
—
9
53
27
201
1.36
0.75
1.4
1.2
—
—
—
0
0
20
141
1.43
0.75
4.5
3.1
9.54
5.09
index
0.36
13
92
404
3847
1.12
0.75
4.3
3.5
33.50
28.49
u/l
1.17
388
3713
53
640
0.81
0.72
1.3
1.4
3.37
3.28
mmol/l
0.27
32
395
9
56
1.61
0.72
1.3
1.1
—
—
—
0
0
26
194
1.35
0.72
1.4
1.2
—
1.26
—
0
8
16
110
1.46
0.69
2.2
1.9
—
—
—
0
0
16
110
1.46
0.69
2.2
1.9
—
—
—
0
0
16
110
1.46
0.69
2.3
1.9
—
—
—
0
0
16
110
1.46
0.69
2.3
1.9
—
—
—
0
0
7
42
1.67
0.68
2.6
3.2
562.00
707.45
u/ml
—
7
42
12
78
1.55
0.66
1.8
3.4
0.67
0.75
e9/l
0.29
12
78
8
128
0.62
0.64
1.1
1.3
—
—
—
0
0
18
129
1.41
0.64
1.3
1.1
—
—
—
0
0
80
916
0.86
0.63
1.3
1.3
12.81
18.75
iu/ml
1.05
18
209
6
104
0.57
0.62
3.8
6.8
—
—
—
0
0
37
298
1.25
0.62
1.3
1.4
—
—
—
0
0
162
1481
1.12
0.62
3.6
2.9
1.02
1.02
kg/l
1.05
104
904
5
30
1.67
0.61
1.2
1.1
—
—
—
0
0
5
30
1.67
0.61
2.2
2.3
107.80
106.37
mmol/l
—
5
30
5
30
1.67
0.61
2.2
2.3
4.00
3.88
mmol/l
—
5
30
21
157
1.35
0.59
1.8
1.6
0.31
0.52
ug/l
—
8
48
8
52
1.54
0.59
1.0
1.1
284.00
297.33
mg/l
—
8
46
6
35
1.72
0.57
1.2
1.5
20.28
22.67
mg/l
—
6
28
6
35
1.72
0.57
1.2
1.5
17.82
27.51
mg/l
—
6
28
16
115
1.40
0.57
1.6
1.9
—
—
—
0
0
34
275
1.25
0.56
5.4
2.6
0.25
0.49
e6/l
0.33
34
259
188
1743
1.11
0.56
3.8
2.6
0.09
0.01
estimate
0.68
66
523
174
1607
1.11
0.56
1.9
1.7
—
—
—
0
0
50
424
1.19
0.54
1.6
1.6
—
—
—
0
0
18
134
1.35
0.53
1.2
1.1
—
—
—
0
0
13
91
1.44
0.53
2.5
1.8
3.98
1.82
ug/l
0.24
13
78
9
62
1.46
0.53
2.3
2.6
—
—
—
0
0
28
223
1.27
0.53
4.0
1.7
1.14
1.17
g/l
0.22
28
212
51
435
1.19
0.52
1.6
1.6
1018.53
1091.32
nmol/l
0.28
45
338
24
188
1.29
0.51
1.6
1.6
—
—
—
0
0
100
1109
0.89
0.51
1.6
1.6
1075.70
972.19
mu/l
0.46
91
997
9
64
1.41
0.51
5.2
3.5
15.67
17.70
index
—
9
53
14
101
1.39
0.50
2.7
4.7
—
—
—
0
0
26
208
1.26
0.48
1.4
1.5
—
7.85
—
0
11
31
376
0.82
0.48
1.0
1.1
—
—
—
0
0
50
434
1.16
0.43
1.1
1.2
6.35
7.76
u/ml
0.26
33
309
27
221
1.23
0.43
4.1
1.7
0.21
0.22
g/l
0.13
27
211
27
222
1.22
0.41
1.1
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.3
—
6.02
—
0
17
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
5
34
1.47
0.40
1.4
1.6
7.02
5.69
mmol/l
—
5
28
49
428
1.16
0.40
1.6
1.6
—
—
—
0
0
13
97
1.35
0.39
1.8
1.6
55.13
38.39
nmol/l
0.64
13
90
54
477
1.14
0.38
1.4
1.3
206.23
248.47
miu/ml
0.38
27
240
5
36
1.39
0.38
8.8
10.5
—
—
—
0
0
44
383
1.16
0.38
1.1
1.1
—
—
—
0
0
95
870
1.11
0.38
1.7
1.5
475.29
508.70
titre
0.07
17
131
157
1474
1.08
0.37
7.4
4.5
—
—
—
0
0
76
837
0.90
0.37
1.2
1.2
13.91
6.99
u/ml
0.25
23
303
19
152
1.26
0.37
2.5
2.1
—
—
—
0
0
24
288
0.83
0.36
1.1
1.0
1.44
1.49
g/l
0.50
24
288
91
989
0.91
0.35
1.7
2.1
—
—
—
0
0
36
312
1.16
0.34
2.7
3.3
4.42
6.69
umol/l
1.18
26
244
232
2220
1.07
0.33
4.4
2.9
0.14
0.01
estimate
0.92
66
528
81
743
1.10
0.32
2.1
2.8
—
—
—
0
0
19
230
0.82
0.32
1.1
1.2
—
—
—
0
0
26
305
0.85
0.32
1.9
1.5
—
—
—
0
0
217
2076
1.07
0.31
2.1
2.0
—
—
—
0
0
19
229
0.83
0.31
1.1
1.2
—
—
—
0
0
17
138
1.24
0.30
1.6
1.7
7.38
7.47
mmol/l
0.05
17
132
19
157
1.22
0.29
1.3
1.2
173.00
226.23
iu/ml
—
5
55
19
158
1.21
0.28
2.2
2.5
0.85
0.67
nmol/l
0.47
19
137
99
1058
0.93
0.28
1.7
2.0
—
—
—
0
0
8
63
1.27
0.28
1.6
5.1
3.82
3.89
mmol/l
—
8
63
49
442
1.12
0.27
2.5
1.8
0.00
0.02
estimate
0.50
17
117
47
425
1.11
0.26
1.1
1.2
2.16
1.15
u/ml
0.62
31
256
99
1054
0.93
0.26
1.7
2.0
—
—
—
0
0
28
245
1.15
0.25
4.4
1.8
10.29
4.24
iu/ml
—
7
39
9
75
1.20
0.25
1.0
1.1
—
—
—
0
0
11
87
1.27
0.24
1.5
3.5
—
—
—
0
0
9
77
1.17
0.24
1.6
1.2
—
—
—
0
0
57
525
1.09
0.23
4.4
3.3
—
—
—
0
0
64
593
1.09
0.23
1.5
1.4
—
—
—
0
0
5
39
1.28
0.23
1.2
1.2
—
—
—
0
0
5
39
1.28
0.23
6.0
3.1
—
—
—
0
0
45
410
1.10
0.22
1.5
1.5
1.22
1.27
mm
0.37
35
316
5
40
1.25
0.22
1.6
2.0
—
—
—
0
0
224
2167
1.05
0.22
2.1
1.8
—
—
—
0
0
99
1046
0.94
0.21
1.7
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
50
1.20
0.19
1.3
1.3
—
—
—
0
0
288
2811
1.04
0.19
2.8
2.4
—
—
—
0
0
100
1051
0.94
0.19
1.7
2.0
—
—
—
0
0
26
290
0.89
0.18
1.2
1.1
0.88
0.86
g/l
0.22
26
290
7
60
1.17
0.18
1.6
2.0
42.86
27.85
mg/l
—
7
39
14
119
1.18
0.18
1.3
1.2
—
—
—
0
0
7
63
1.11
0.17
1.7
1.3
7.88
2.76
u/ml
—
7
63
51
477
1.07
0.16
2.0
2.7
—
—
—
0
0
195
2003
0.96
0.15
2.3
2.0
—
—
—
0
0
9
81
1.11
0.15
1.8
5.3
1.27
1.52
mmol/l
—
9
81
9
82
1.10
0.15
2.0
1.2
—
—
—
0
0
50
472
1.06
0.13
1.1
1.2
4.80
3.45
u/ml
0.19
33
299
44
416
1.06
0.11
1.1
1.2
6.40
2.45
u/ml
1.00
28
265
31
289
1.08
0.11
1.1
1.1
8.04
9.07
u/ml
0.09
17
162
21
192
1.10
0.11
1.5
1.4
—
—
—
0
0
10
115
0.87
0.10
1.6
1.6
0.52
0.50
e9/l
—
10
115
5
48
1.04
0.09
1.0
1.8
—
—
—
0
0
10
88
1.14
0.08
7.2
1.5
13.23
12.85
%
—
10
88
6
72
0.83
0.07
1.0
1.1
—
—
—
0
0
12
108
1.11
0.07
1.0
1.1
—
—
—
0
0
44
422
1.05
0.07
1.9
1.9
6.38
6.36
ph
0.06
33
269
9
85
1.06
0.07
2.0
1.2
—
—
—
0
0
88
863
1.02
0.05
1.7
2.1
—
—
—
0
0
17
180
0.94
0.04
1.0
1.2
—
—
—
0
0
91
896
1.02
0.03
2.9
2.5
11723.08
6658.80
u/l
0.56
34
342
30
310
0.97
0.03
1.1
1.1
4.92
6.67
u/ml
0.34
21
187
24
231
1.04
0.03
1.6
1.7
4.03
4.93
u/ml
—
6
57
19
198
0.96
0.02
1.4
2.0
22.95
41.01
u/ml
1.01
19
190
58
572
1.02
0.01
1.6
1.6
65.33
61.17
ug/l
0.28
53
510
29
283
1.03
0.01
1.1
1.1
0.03
0.56
u/ml
1.52
13
113
62
626
0.99
0.00
1.9
2.1
—
—
—
0
0
21
213
0.99
0.00
1.4
1.1
—
—
—
0
0
10
102
0.98
0.00
1.4
1.3
39.60
45.26
pmol/l
—
10
97
21
208
1.01
0.00
1.7
2.1
3.10
3.86
iu/l
—
6
99
28
279
1.00
0.00
4.4
4.1
7.38
7.32
ph
1.94
19
216
48
479
1.00
0.00
1.5
1.3
—
—
—
0
0
9
94
0.96
0.00
1.7
1.3
—
296.00
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
2.14
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
2.83
—
0
6
0
6
0.00
-0.00
0.0
1.7
—
468.00
—
0
6
0
7
0.00
-0.00
0.0
3.1
—
0.54
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
409.22
—
0
6
5
56
0.89
-0.00
1.8
1.9
—
—
—
0
0
5
56
0.89
-0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
17.02
—
0
5
5
55
0.91
-0.00
1.6
5.3
—
32.38
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
17.91
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
13.19
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
0.23
—
0
5
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
235
2350
1.00
-0.00
1.8
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
59.71
—
0
7

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: E4_DISPUB_ALL – Disorders of puberty, all

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).